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Journal articles on the topic 'Hypothalamic amenorrhea'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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1

Warren, Michelle P., and Joanna L. Fried. "HYPOTHALAMIC AMENORRHEA." Endocrinology and Metabolism Clinics of North America 30, no. 3 (2001): 611–29. http://dx.doi.org/10.1016/s0889-8529(05)70204-8.

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2

Keller, Jennifer L., and Kenneth Faber. "Hypothalamic Amenorrhea." Postgraduate Obstetrics & Gynecology 28, no. 21 (2008): 1–5. http://dx.doi.org/10.1097/01.pgo.0000337875.34050.5a.

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3

&NA;. "Hypothalamic Amenorrhea." Postgraduate Obstetrics & Gynecology 28, no. 21 (2008): 6. http://dx.doi.org/10.1097/01.pgo.0000337876.41673.71.

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4

Meczekalski, B., A. Tonetti, P. Monteleone, et al. "Hypothalamic amenorrhea with normal body weight: ACTH, allopregnanolone and cortisol responses to corticotropin-releasing hormone test." European Journal of Endocrinology 142, no. 3 (2000): 280–85. http://dx.doi.org/10.1530/eje.0.1420280.

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OBJECTIVE: Hypothalamic amenorrhea (HA) is a functional disorder caused by disturbances in gonadotropin-releasing hormone (GnRH) pulsatility. The mechanism by which stress alters GnRH release is not well known. Recently, the role of corticotropin-releasing hormone (CRH) and neurosteroids in the pathophysiology of HA has been considered. The aim of the present study was to explore further the role of the hypothalamic-pituitary-adrenal axis in HA. DESIGN: We included 8 patients (aged 23.16+/-1.72 years) suffering from hypothalamic stress-related amenorrhea with normal body weight and 8 age-match

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5

Podfigurna, Agnieszka, and Blazej Meczekalski. "Functional Hypothalamic Amenorrhea: A Stress-Based Disease." Endocrines 2, no. 3 (2021): 203–11. http://dx.doi.org/10.3390/endocrines2030020.

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The aim of the study is to present the problem of functional hypothalamic amenorrhea, taking into account any disease and treatment, diagnosis, and consequences of this disease. We searched PubMed (MEDLINE) and included 38 original and review articles concerning functional hypothalamic amenorrhea. Functional hypothalamic amenorrhea is the most common cause of secondary amenorrhea in women of childbearing age. It is a reversible disorder caused by stress related to weight loss, excessive exercise and/or traumatic mental experiences. The basis of functional hypothalamic amenorrhea is hormonal, b

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6

Gordon, Catherine M. "Functional Hypothalamic Amenorrhea." New England Journal of Medicine 363, no. 4 (2010): 365–71. http://dx.doi.org/10.1056/nejmcp0912024.

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7

Berga, Sarah L. "Functional hypothalamic amenorrhea." Current Opinion in Endocrinology & Diabetes 8, no. 6 (2001): 307–13. http://dx.doi.org/10.1097/00060793-200112000-00008.

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8

Warren, M. P., F. Voussoughian, E. B. Geer, E. P. Hyle, C. L. Adberg, and R. H. Ramos. "Functional Hypothalamic Amenorrhea." Obstetrical & Gynecological Survey 54, no. 8 (1999): 510–11. http://dx.doi.org/10.1097/00006254-199908000-00017.

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9

Ferin, M. "Stress and hypothalamic amenorrhea." Gynecological Endocrinology 10, sup4 (1996): 42–43. http://dx.doi.org/10.3109/09513599609116179.

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10

Guay, Andre T., Sudhir Bansal, and Mary Beth Hodge. "Possible hypothalamic impotencemale counterpart to hypothalamic amenorrhea?" Urology 38, no. 4 (1991): 317–22. http://dx.doi.org/10.1016/0090-4295(91)80143-u.

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11

Aurigemma, Nicole C. "Pathways To Functional Hypothalamic Amenorrhea." Medicine & Science in Sports & Exercise 50, no. 5S (2018): 95–96. http://dx.doi.org/10.1249/01.mss.0000535399.48422.29.

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12

Fourman, Lindsay T., and Pouneh K. Fazeli. "Neuroendocrine Causes of Amenorrhea—An Update." Journal of Clinical Endocrinology & Metabolism 100, no. 3 (2015): 812–24. http://dx.doi.org/10.1210/jc.2014-3344.

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Context: Secondary amenorrhea—the absence of menses for three consecutive cycles—affects approximately 3–4% of reproductive age women, and infertility—the failure to conceive after 12 months of regular intercourse—affects approximately 6–10%. Neuroendocrine causes of amenorrhea and infertility, including functional hypothalamic amenorrhea and hyperprolactinemia, constitute a majority of these cases. Objective: In this review, we discuss the physiologic, pathologic, and iatrogenic causes of amenorrhea and infertility arising from perturbations in the hypothalamic-pituitary-adrenal axis, includi

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13

Boesgaard, Søren, Claus Hagen, Anders Nyboe Andersen, Henning Djursing, and Mogens Fenger. "Cortisol secretion in patients with normoprolactinemic amenorrhea." Acta Endocrinologica 118, no. 4 (1988): 544–50. http://dx.doi.org/10.1530/acta.0.1180544.

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Abstract. Patients with functional amenorrhea have raised central dopaminergic activity and opioid-mediated GnRH inhibition leading to inhibition of hypothalamic-pituitary-ovarian function. In the present study, basal serum cortisol and ACTH levels were measured in normoprolactinemic amenorrheic patients with (N = 14) and without (N = 7) insulin-dependent diabetes mellitus. Basal serum cortisol levels was significantly (P < 0.01) elevated in patients with normoprolactinemic amenorrhea compared with normal women. Basal serum cortisol was significantly (P < 0.02) elevated in amenorheic dia

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14

Schuiling, G. A., N. Valkhof, T. R. Koiter, and R. M. Lappöhn. "Differential effect of estrogen on pituitary responsiveness to GnRH in women with different forms of hypothalamic amenorrhea." Acta Endocrinologica 122, no. 5 (1990): 651–55. http://dx.doi.org/10.1530/acta.0.1220651.

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Abstract. The effect of treatment with estradiol valerate (6 days, 2-6 mg/day) on basal levels of LH and FSH and on response of LH and FSH levels to GnRH challenge (2 × 25 μg GnRH, iv) were investigated in women with "hypothalamic amenorrhea", but without other endocrine disorders. Three groups were studied: 11 women with primary amenorrhea, 10 women exhibiting secondary amenorrhea related with weight loss, and 7 women with normal weight and with amenorrhea persisting after a period of severe weight loss. Before treatment with estradiol valerate the estradiol concentrations in all women were a

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15

Ghaffari, Firouzeh, Fatemeh Keikha, and Arezoo Arabipoor. "A Rare Case of Primary Amenorrhea with Two Etiologies, Hypothalamic Amenorrhea, Transverse Vaginal Septum, and No Hematocolpos." Case Reports in Obstetrics and Gynecology 2015 (2015): 1–3. http://dx.doi.org/10.1155/2015/989123.

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We reported a rare case of hypothalamic amenorrhea and transverse vaginal septum. A 28-year-old woman presented with primary amenorrhea and no complaint of abdominal pain. Laparoscopy revealed a small rudimentary uterus with streak ovaries and a vaginal pouch. The patient with diagnosis of Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome was subjected to a vaginoplasty in another fertility center. In our institute, after two courses of estrogen and progesterone, sonography revealed hematocolpos, while, under anesthesia, transverse vaginal septum was resected. Hysteroscopy revealed normal uterine

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16

Koltun, Kristen J., Nancy I. Williams, Jennifer L. Scheid, and Mary Jane De Souza. "Discriminating hypothalamic oligomenorrhea/amenorrhea from hyperandrogenic oligomenorrhea/amenorrhea in exercising women." Applied Physiology, Nutrition, and Metabolism 45, no. 7 (2020): 707–14. http://dx.doi.org/10.1139/apnm-2019-0640.

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The mechanism underlying oligo/amenorrhea in exercising women is often presumed as hypothalamic inhibition secondary to energy deficiency; however, hyperandrogenism may provide an alternative mechanism in some exercising women. Our purpose was to compare reproductive, metabolic, and androgen profiles of exercising women with eumenorrheic, ovulatory menstrual cycles (n = 91), oligo/amenorrhea without evidence of hyperandrogenism (Oligo/Amen; n = 83), and oligo/amenorrhea with evidence of hyperandrogenism (Oligo/Amen-HA; n = 17), and determine the prevalence of oligo/amenorrhea with evidence of

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17

Yen, Samuel S. C. "Female Hypogonadotropic Hypogonadism: Hypothalamic Amenorrhea Syndrome." Endocrinology and Metabolism Clinics of North America 22, no. 1 (1993): 29–58. http://dx.doi.org/10.1016/s0889-8529(18)30179-8.

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18

Marcus, Marsha D., Tammy L. Loucks, and Sarah L. Berga. "Psychological correlates of functional hypothalamic amenorrhea." Fertility and Sterility 76, no. 2 (2001): 310–16. http://dx.doi.org/10.1016/s0015-0282(01)01921-5.

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19

Ahima, Rexford S. "Body Fat, Leptin, and Hypothalamic Amenorrhea." New England Journal of Medicine 351, no. 10 (2004): 959–62. http://dx.doi.org/10.1056/nejmp048214.

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20

Berga, Sarah L., and Lyda G. Girton. "The Psychoneuroendocrinology of Functional Hypothalamic Amenorrhea." Psychiatric Clinics of North America 12, no. 1 (1989): 105–16. http://dx.doi.org/10.1016/s0193-953x(18)30454-4.

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21

Warren, Michelle P., Claire C. Holderness, Valerie Lesobre, Raphaelle Tzen, Farnaz Vossoughian, and J. Brooks-Gunn. "Hypothalamic Amenorrhea and Hidden Nutritional Insults." Journal of the Society for Gynecologic Investigation 1, no. 1 (1994): 84–88. http://dx.doi.org/10.1177/107155769400100117.

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22

Collins, Taylor, and Krista L. Rompolski. "Hypothalamic Amenorrhea: Causes, Complications, & Controversies." Journal of Student Research 6, no. 1 (2017): 24–32. http://dx.doi.org/10.47611/jsr.v6i1.288.

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Hypothalamic amenorrhea (HA) is considered a reversible condition characterized by the absence of menses for 3 months or more, due to suppressed secretions of gonadotropin releasing hormone affecting the entire hypothalamic-pituitary-ovarian axis. HA can be triggered by excessive stress, weight loss or excessive exercise, however, the etiology is still largely unknown. Serious, long-term complications include severe hypoestrogenism and infertility, in addition to a variety of hormonal aberrations. Hypoestrogenism also leads to diminished bone health, cardiovascular problems, and mood changes t

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23

Strisanti, Ida Ayu Suptika. "AKUPUNKTUR TERAPI UNTUK MENURUNKAN LEVEL ANSIETAS PADA WANITA DENGAN WEIGHT LOSS RELATED AMENORRHEA: A PILOT STUDY." Jurnal Riset Kesehatan Nasional 4, no. 1 (2020): 60. http://dx.doi.org/10.37294/jrkn.v4i1.227.

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ABSTRAKLatar Belakang: Weight loss related amenorrhea merupakan suatu kondisi amenorea yang disebabkan oleh disfungsi hypothalamus atau disebut juga dengan Functional Hypothalamic Amenorrhea (FHA). Ketika seorang wanita mengalami amenorea dalam jangka waktu yang relatif lama, tentunya kondisi ini akan mempengaruhi psikologis wanita tersebut. Oleh sebab itu, mengkaji kondisi psikis dari wanita yang menderita weight loss related amenorrhea dan membantu menurunkan level ansietasnya juga sangat di perlukan. Pilot study ini dilakukan untuk mengetahui efek dari akupunktur terapi untuk menurunkan lev

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24

Grinspoon, Steven, Karen Miller, Caryn Coyle, et al. "Severity of Osteopenia in Estrogen-Deficient Women with Anorexia Nervosa and Hypothalamic Amenorrhea1." Journal of Clinical Endocrinology & Metabolism 84, no. 6 (1999): 2049–55. http://dx.doi.org/10.1210/jcem.84.6.5792.

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Reduced bone density is observed in over half of women with anorexia nervosa (AN), in whom the risk of fracture is significantly increased even at a young age. It is unknown to what extent low bone density in AN differs from other conditions of premenopausal osteoporosis and is related to estrogen deficiency and/or other factors, such as nutritional status. We therefore investigated bone loss in nutritionally replete and nutritionally deplete amenorrheic women by comparing patients with AN (n = 30) to age-matched subjects with hypothalamic amenorrhea (HA; n = 19) in whom duration of amenorrhea

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25

Torbati, Tina, Erika Dutra, and Chrisandra Shufelt. "Hypothalamic Amenorrhea and the Long-Term Health Consequences." Seminars in Reproductive Medicine 35, no. 03 (2017): 256–62. http://dx.doi.org/10.1055/s-0037-1603581.

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AbstractThe menstrual cycle is a reproductive vital sign and provides insight into hormonal imbalance as well as pregnancy. The significance of estrogen, however, extends beyond fertility and plays a role on tissues and organs throughout the body. Functional hypothalamic amenorrhea is a common form of secondary amenorrhea resulting in estrogen deficiency in young premenopausal women. While reversible, the cause of this disorder is related to psychological stress, excessive exercise, disordered eating, or a combination of these factors resulting in suppression of the hypothalamic–pituitary–ovar

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26

O'Donnell, Emma, John S. Floras, and Paula J. Harvey. "Estrogen status and the renin angiotensin aldosterone system." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 307, no. 5 (2014): R498—R500. http://dx.doi.org/10.1152/ajpregu.00182.2014.

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The renin-angiotensin-aldosterone system (RAAS) is integrally involved in multiple cardiovascular physiological processes including arterial blood pressure (BP) regulation. Over activity of the RAAS has been implicated in the pathogenesis of a number of cardiovascular disease entities, including hypertension. Several lines of evidence suggest estrogen favorably modulates the RAAS. Conversely, estrogen deficiency due to menopause may contribute to over activity of the RAAS. Of importance, estrogen deficiency in women is not exclusive to the postmenopausal period. Functional hypothalamic amenorr

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27

Tschugguel, Walter, and Sarah L. Berga. "Treatment of functional hypothalamic amenorrhea with hypnotherapy." Fertility and Sterility 80, no. 4 (2003): 982–85. http://dx.doi.org/10.1016/s0015-0282(03)01012-4.

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28

Stockman, J. A. "A Genetic Basis for Functional Hypothalamic Amenorrhea." Yearbook of Pediatrics 2012 (January 2012): 125–27. http://dx.doi.org/10.1016/j.yped.2011.06.033.

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29

SUH, B. Y., J. H. LIU, S. L. BERGA, M. E. QUIGLEY, G. A. LAUGHLIN, and S. S. YEN. "Hypercortisolism in Patients with Functional Hypothalamic-Amenorrhea." Obstetrical & Gynecological Survey 43, no. 11 (1988): 691–92. http://dx.doi.org/10.1097/00006254-198811000-00016.

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30

Warren, M. P., F. Voussoughian, E. B. Geer, E. P. Hyle, C. L. Adberg, and R. H. Ramos. "Functional Hypothalamic Amenorrhea: Hypoleptinemia and Disordered Eating." Journal of Clinical Endocrinology & Metabolism 84, no. 3 (1999): 873–77. http://dx.doi.org/10.1210/jcem.84.3.5551.

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31

Caronia, Lisa M., Cecilia Martin, Corrine K. Welt, et al. "A Genetic Basis for Functional Hypothalamic Amenorrhea." New England Journal of Medicine 364, no. 3 (2011): 215–25. http://dx.doi.org/10.1056/nejmoa0911064.

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32

Caronia, Lisa M., Cecilia Martin, Corrine K. Welt, et al. "A Genetic Basis for Functional Hypothalamic Amenorrhea." Obstetrical & Gynecological Survey 66, no. 10 (2011): 618–19. http://dx.doi.org/10.1097/ogx.0b013e31822f94c4.

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33

RUIZ-ZAMBRANA, ALVARO, and SARAH L. BERGA. "A Clinician’s Guide to Functional Hypothalamic Amenorrhea." Clinical Obstetrics & Gynecology 63, no. 4 (2020): 706–19. http://dx.doi.org/10.1097/grf.0000000000000573.

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34

SUH, B. Y., J. H. LIU, S. L. BERGA, M. E. QUIGLEY, G. A. LAUGHLIN, and S. S. YEN. "Hypercortisolism in Patients With Functional Hypothalamic-Amenorrhea*." Journal of Clinical Endocrinology & Metabolism 66, no. 4 (1988): 733–39. http://dx.doi.org/10.1210/jcem-66-4-733.

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35

GENAZZANI, A. D., F. RICCHIERI, C. LANZONI, C. STRUCCHI, and V. M. JASONNI. "Diagnostic and Therapeutic Approach to Hypothalamic Amenorrhea." Annals of the New York Academy of Sciences 1092, no. 1 (2006): 103–13. http://dx.doi.org/10.1196/annals.1365.009.

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36

Liu, James H. "Hypothalamic amenorrhea: Clinical perspectives, pathophysiology, and management." American Journal of Obstetrics and Gynecology 163, no. 5 (1990): 1732–36. http://dx.doi.org/10.1016/0002-9378(90)91437-h.

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37

Genazzani, A. D., E. Chierchia, S. Santagni, E. Rattighieri, A. Farinetti, and C. Lanzoni. "Hypothalamic amenorrhea: From diagnosis to therapeutical approach." Annales d'Endocrinologie 71, no. 3 (2010): 163–69. http://dx.doi.org/10.1016/j.ando.2010.02.006.

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38

Anu Prasad, N. "AN OVERVIEW OF AMENORRHEA." Journal of Medical pharmaceutical and allied sciences 10, no. 3 (2021): 2724–28. http://dx.doi.org/10.22270/jmpas.v10i3.1063.

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Amenorrhea is defined as the nonappearance of menstruation in women. Amenorrhea may be divided in to primary and secondary amenorrhea. Primary amenorrhea is caused due to anatomical, genetic, nutritional and other endocrine defects. Anatomical causes includes distal obstruction, MRKH and AIS. Primary Ovarian Insufficiency is the foremost causes of primary amenorrhea. The frequent causes of secondary amenorrhea are pregnancy. Other causes of secondary amenorrhea include PCOD, functional hypothalamic amenorrhea, POI. Depending upon the causes, the amenorrhea affected women should experiences the

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39

Grosman-Rimon, Liza, Evan Wright, Danit Freedman, et al. "Can improvement in hormonal and energy balance reverse cardiovascular risk factors in athletes with amenorrhea?" American Journal of Physiology-Heart and Circulatory Physiology 317, no. 3 (2019): H487—H495. http://dx.doi.org/10.1152/ajpheart.00242.2019.

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Female athletes display a high prevalence of hypothalamic amenorrhea as a result of energy imbalance. In these athletes with amenorrhea, decreased luteinizing hormone/follicule-stimulating hormone secretion leads to deficiency in endogenous estrogen. The severe estrogen deficiency in these athletes may increase cardiovascular risk similar to that in postmenopausal women. This review discusses the potential cardiovascular risk factors in athletes with amenorrhea as a result of hypoestrogenism, which include endothelial dysfunction and unfavorable lipid profiles. We also consider the potential t

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40

Webb, S. M. "Circulating melatonin in hypothalamic amenorrhea: Cause or effect?" Gynecological Endocrinology 10, sup4 (1996): 37–38. http://dx.doi.org/10.3109/09513599609116177.

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41

Genazzani, A. D., F. Petraglia, L. Sgarbi, et al. "Chronobiological derangement of pituitary hormones in hypothalamic amenorrhea." Gynecological Endocrinology 10, sup4 (1996): 38–41. http://dx.doi.org/10.3109/09513599609116178.

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42

Chernukha, Chernukha G. E., Gusev D. V. Gusev, Tabeeva G. I. Tabeeva, and Prilutskaya V. Yu Prilutskaya. "Current principles of therapy for functional hypothalamic amenorrhea." Akusherstvo i ginekologiia 6_2018 (July 2, 2018): 11–17. http://dx.doi.org/10.18565/aig.2018.6.11-17.

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43

Chou, S. H., J. P. Chamberland, X. Liu, et al. "Leptin is an effective treatment for hypothalamic amenorrhea." Proceedings of the National Academy of Sciences 108, no. 16 (2011): 6585–90. http://dx.doi.org/10.1073/pnas.1015674108.

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44

Meczekalski, Blazej, Agnieszka Podfigurna-Stopa, Alina Warenik-Szymankiewicz, and Andrea Riccardo Genazzani. "Functional hypothalamic amenorrhea: Current view on neuroendocrine aberrations." Gynecological Endocrinology 24, no. 1 (2008): 4–11. http://dx.doi.org/10.1080/09513590701807381.

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45

Chou, Sharon H., and Christos Mantzoros. "Bone metabolism in anorexia nervosa and hypothalamic amenorrhea." Metabolism 80 (March 2018): 91–104. http://dx.doi.org/10.1016/j.metabol.2017.10.009.

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46

Alexander, L. "Human Recombinant Leptin for Treatment of Hypothalamic Amenorrhea." MD Conference Express 11, no. 5 (2011): 9. http://dx.doi.org/10.1177/155989771105003.

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47

Welt, Corrine K., Jean L. Chan, John Bullen, et al. "Recombinant Human Leptin in Women with Hypothalamic Amenorrhea." New England Journal of Medicine 351, no. 10 (2004): 987–97. http://dx.doi.org/10.1056/nejmoa040388.

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48

BERGA, S. L., J. F. MORTOLA, L. GIRTON, et al. "Neuroendocrine Aberrations in Women With Functional Hypothalamic Amenorrhea*." Journal of Clinical Endocrinology & Metabolism 68, no. 2 (1989): 301–8. http://dx.doi.org/10.1210/jcem-68-2-301.

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49

Welt, Corrine K., Jean L. Chan, John Bullen, et al. "Recombinant Human Leptin in Women With Hypothalamic Amenorrhea." Obstetrical & Gynecological Survey 60, no. 2 (2005): 104–5. http://dx.doi.org/10.1097/01.ogx.0000151645.22134.0b.

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50

Lania, A., L. Gianotti, I. Gagliardi, M. Bondanelli, W. Vena, and M. R. Ambrosio. "Functional hypothalamic and drug-induced amenorrhea: an overview." Journal of Endocrinological Investigation 42, no. 9 (2019): 1001–10. http://dx.doi.org/10.1007/s40618-019-01013-w.

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