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Dissertations / Theses on the topic 'Hypoxia-Inducible'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Lau, Yue-huen Thomas. "Nuclear transcription factors and hypoxia-inducible genes in chronic liver hypoxia." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31939302.

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Lau, Yue-huen Thomas, and 劉汝這. "Nuclear transcription factors and hypoxia-inducible genes in chronic liver hypoxia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31939302.

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3

Laitala, A. (Anu). "Hypoxia-inducible factor prolyl 4-hydroxylases regulating erythropoiesis, and hypoxia-inducible lysyl oxidase regulating skeletal muscle development during embryogenesis." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526206943.

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Abstract Erythropoiesis is the process of red blood cell production. The main regulator is the erythropoietin (EPO) hormone, which is strongly upregulated in low oxygen concentration (hypoxia) in cells via the hypoxia-inducible transcription factor HIF. The stability of HIF is regulated in an oxygen-dependent manner by three HIF prolyl 4-hydroxylases, all of which are known to participate in the regulation of erythropoiesis. A role in erythropoiesis of a fourth prolyl 4-hydroxylase, P4H-TM, which possesses a transmembrane domain, is not known, but it is able to hydroxylate HIF at least in vitr

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4

Lidgren, Anders. "Hypoxia inducible factor-1α in renal cell carcinoma". Doctoral thesis, Umeå universitet, Kirurgisk och perioperativ vetenskap, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1462.

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Hypoxia Inducible Factor-1α in Renal Cell Carcinoma Departments of Surgical and Perioperative Sciences, Urology and Andrology; Radiation Sciences, Oncology; Medical Biosciences, Pathology; and Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden Background: Renal cell carcinoma (RCC) accounts for approximately 2-3% of all human cancers. A distinguished feature of RCC is vascularisation and among the three dominating RCC types conventional RCC (cRCC) generally is more vascularised than papillary RCC (pRCC) and chromophobe RCC (chRCC). Angiogenesis is a critical step in tumour

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5

Wilson, William J. "Hypoxia inducible factor 1a : molecular mechanisms of regulation /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-223-X.

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6

Miles, Anna Louise. "V-ATPase regulation of Hypoxia Inducible transcription Factors." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/283217.

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Metazoans have evolved conserved mechanisms to promote cell survival under low oxygen tensions by initiating a transcriptional cascade centered on the action of Hypoxia Inducible transcription Factors (HIFs). In aerobic conditions, HIFs are inactivated by ubiquitin-proteasome-mediated degradation of their a subunit, which is dependent on prolyl hydroxylation by 2-oxoglutarate (2-OG) and Fe(II)-dependent prolyl hydroxylases (PHDs). In hypoxia, HIF-$\alpha$ is no longer hydroxylated and is therefore stabilised, activating a global transcriptional response to ensure cell survival. Interestingly,

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7

Chan, Mun Chiang. "Inhibition studies on hypoxia-inducible factor (HIF) hydroxylases." Thesis, University of Oxford, 2014. https://ora.ox.ac.uk/objects/uuid:5c8a24bd-3acc-4271-a24b-8bd601d7a807.

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The hypoxia-inducible factor (HIF) is a key regulator of transcriptional responses to hypoxia in animals. As part of the cellular response to decreased oxygen concentrations, the transcriptional activity of a heterodimeric complex consisting of HIFα and HIFβ activates the expression of hundreds of target genes, including those involved in cellular growth, apoptosis, energy metabolism and angiogenesis. HIFα prolyl hydroxylation, as catalysed by the HIF prolyl hydroxylases (PHDs), leads to subsequent HIFÎ± polyubiquitination and proteasomal degradation. HIFα asparaginyl hy

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8

Lau, Chi-keung, та 劉智強. "Blockade of hypoxia inducible factor-1α sensitizes hepatocellular carcinoma to hypoxia and chemotherapy". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39634243.

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Lau, Chi-keung. "Blockade of hypoxia inducible factor-1[alpha] sensitizes hepatocellular carcinoma to hypoxia and chemotherapy." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39634243.

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10

Hägg, Maria. "Hypoxia-inducible factors (HIFs) and biological responses in hypoxia, inflammation and embryonic vascular development /." Göteborg: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, 2008. http://hdl.handle.net/2077/9991.

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11

Mohammed, Asjad Kaleem. "Anticancer natural products that target hypoxia-inducible factor-1 /." Full text available from ProQuest UM Digital Dissertations, 2005. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1260789291&SrchMode=1&sid=4&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1185218250&clientId=22256.

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12

Kai, Ka-lun Alan, and 奚家麟. "Roles of hypoxia-inducible microRNA-210 in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/200359.

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Hepatocellular carcinoma (HCC) is the fifth most prevalent human malignancy and the third leading cause of cancer deaths in the world. MicroRNAs (miRNA) are conserved, small noncoding RNA molecules that regulate gene expression of protein-coding gene posttranscriptionally. Dysregulation of miRNA is implicated in many human malignancies including HCC, yet little is known regarding the regulatory mechanisms of these small noncoding RNAs. Hypoxia is a prevalent! tumor microenvironment in HCC because of its rapid growth often to large size and plays a key role in modulating tumor aggressiveness.

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13

Nordgren, Ida Karin. "Selection of cyclic peptide inhibitors of hypoxia-inducible factor." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/344931/.

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Hypoxia-inducible factor (HIF) is a heterodimer that is formed from the association of HIF-α and HIF-1β subunits. HIF acts as a potent inducer of genes involved in angiogenesis and neovascularisation. Three different variants of HIF have been identified to date; HIF-1 and HIF-2 are thought to play key roles in tumour blood vessel formation while with HIF-3 is thought to act as a negative regulator of the hypoxic response. In this study a genetic selection methodology is employed that combines a bacterial reverse two-hybrid system with SICLOPPS (split-intein circular ligation of peptides and pr

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14

Lim, Chung Sim. "The hypoxia-inducible factor (HIF) pathway in varicose veins." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6999.

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Primary varicose vein wall weakness and dilatation are thought to be caused by various biochemical and structural changes. Hypoxia and mechanical stress have been postulated to contribute to primary varicose vein wall changes. Hypoxia-inducible factors (HIF) are nuclear transcriptional factors that regulate the transcription of genes of oxygen homoeostasis. The HIF pathway is regulated by factors including oxygen tension and mechanical stress. The study aimed to assess the expression of HIF and its target genes in varicose and non-varicose veins, and examine their regulation by hypoxia, mechan

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15

Khan, Moddasar N. "The biological role of factor-inhibiting hypoxia-inducible factor." Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/4645.

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Factor Inhibiting Hypoxia-inducible Factor (FIH) is an asparaginyl hydroxylasewhich regulates the transcription factor Hypoxia-Inducible Factor (HIF), viahydroxylation of a conserved asparagine residue of the HIF-alpha subunits (twoisoforms of which are well established, HIF-1 and HIF-2alpha - HIF-3alpha isless well characterized currently). Other targets of FIH have also been reported. Little is known about both FIH expression and function. This thesis willinvestigate the expression of FIH in rodents, in cell lines and in renal cancertissue samples. In addition, RNAi technology was used to st

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16

Oda, Tomoyuki. "Activation of hypoxia-inducible factor 1 during macrophage differentiation." Kyoto University, 2007. http://hdl.handle.net/2433/135669.

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17

Nath, Bharath D. "Hypoxia Inducible Factors in Alcoholic Liver Disease: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/525.

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Chronic intake of alcohol can result in a range of pathology in the liver. Whilst the earliest changes observed with chronic ethanol, including the accumulation of lipid, or steatosis, are readily reversible upon cessation of alcohol consumption, longer exposure to ethanol may achieve more complex disease states including steatohepatitis, fibrosis, and cirrhosis that can cause irreversible damage and progress to fulminant hepatic failure. A key concept in the pathogenesis of alcoholic liver disease is that chronic ethanol primes the liver to increased injury through an interplay between hepato

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18

Liu, Yu. "Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1." Kyoto University, 2013. http://hdl.handle.net/2433/179346.

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19

Dalgard, Clifton Lee. "Hypoxia-inducible factor hydroxylases are oxygen sensors in the brain /." Download the dissertation in PDF, 2005. http://www.lrc.usuhs.mil/dissertations/pdf/Dalgard2005.pdf.

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20

Harvey, Alexandra Juanita. "Expression of hypoxia-inducible factors during bovine preimplantation embryo development /." Title page, abstract and table of contents only, 2003. http://web4.library.adelaide.edu.au/theses/09PH/09phh3410.pdf.

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21

Kaewpet, Morakot. "Design and synthesis of inhibitors of hypoxia inducible factor hydroxylases." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526474.

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22

Tam, Wai-kit, та 譚偉傑. "Role of hypoxia inducible factor-alpha (HIF-α) genes inchondrogenesis". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47849770.

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Cartilage is an essential skeletal connective tissue in vertebrates. It comprises extracellular matrix components, especially for collagens and proteoglycans. Once the cartilage is damaged, it has limited self-repair capacity. Thus, by understanding the dynamic cellular process of chondrogenesis and chondrocyte differentiation would be necessary in developing therapeutic approaches for cartilage repair. Currently, there is a great interest in the development of cell therapy to repair damaged tissues. In particularly, human mesenchymal stem cells (hMSCs) are attractive candidates for th

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23

Formenti, Federico. "The role of hypoxia-inducible factor in systemic human physiology." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:421232a5-1bab-4612-a6d4-30bdb35beb7a.

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This thesis summarizes a research programme on the role of hypoxia-inducible factor (HIF) and its 2alpha subunit in systemic human physiology. Experiments were performed to assess the role of HIF in the regulation of skeletal muscle metabolism, cardiac anatomy, function and energy metabolism, and in cardiopulmonary physiology. Patients with different genetic mutations affecting the HIF pathway were recruited for each main study. Chapter 1 presents an overview of human physiological responses to hypoxia in a historical perspective, with particular attention to the areas of human physiology that

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24

Wakamatsu, Takuhiko. "The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activation." Kyoto University, 2010. http://hdl.handle.net/2433/120562.

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25

Knight, Laura K. "The effect of hypoxia and the transcription factor hypoxia inducible factor-1 (HIF-1) on metastasis." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502269.

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Tumour hypoxia has been widely implicated in the development of aggressive, therapy resistant malignant disease. Patients presenting with more hypoxic tumours experience higher levels of mortality compared to those with lower levels of hypoxia. The primary reason or this increased phenotype is the stabilisation of the transcription factor hypoxia inducible factor-1 (HIF-1). Upon exposure to hypoxic conditions, the alpha subunit of this heterodimer Stabilised and binds to the beta subunit. Once stabilised HIF-1 induces gene expression resulting in the Increased exproression of a number of prote

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26

Lim, Ai Lin. "Characterization of hypoxia-induced gene (HIG2) and hypoxia-inducible autophagy as novel pathways of tumor growth /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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27

Taheem, Dheraj Kumar. "A role for hypoxia and hypoxia inducible factor during chondrogenesis of bone marrow mesenchymal stem cells." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/a-role-for-hypoxia-and-hypoxia-inducible-factor-during-chondrogenesis-of-bone-marrow-mesenchymal-stem-cells(8f516122-6cd6-4c9b-91f6-bede34427fd5).html.

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Articular cartilage lesions cause pain, morbidity and may progress to osteoarthritis, which in terms of medical care, has been approximated to cost 1-2.5% of the gross national product of USA, UK, France and other countries. Current repair strategies have considerable limitations and have prompted the development of cartilage tissue engineering (CTE) approaches. One of the challenges of CTE is the expansion and differentiation of adult stem cells in vitro, into functional articular chondrocytes whilst avoiding hypertrophy. Hypoxia is an important environmental factor required for cartilage dev

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28

Pasanen, A. (Annika). "Prolyl 3-hydroxylases and hypoxia-inducible factor 3:their roles in collagen synthesis and hypoxia response, respectively." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514294594.

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Abstract Collagens are subject to extensive post-translational modifications, including the formation of 4-hydroxyproline, 3-hydroxyproline and hydroxylysine. These reactions are catalyzed by collagen prolyl 4-hydroxylases (C-P4Hs), prolyl 3-hydroxylases (P3Hs) and lysine hydroxylases (LHs), which belong to the 2-oxoglutarate-dependent dioxygenase family and require oxygen for their reaction. 4-Hydroxyproline residues have for a long time been known to be required for the stability of the collagen triple helix, but the role of prolyl 3-hydroxylation was revealed only a few years ago when mutat

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29

Measures, Elaine Maria. "Hypoxia-inducible factor (HIF)transactivation in a chronic hypoxia model : HIF disruption as an anti-cancer strategy." Thesis, University of Manchester, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548996.

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30

MacDuff, Andrew. "Role of myeloid Hif-1α in acute lung injury". Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5581.

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Acute Lung Injury, characterised clinically as the Acute Respiratory Distress Syndrome is a catastrophic response to a range of pulmonary and non-pulmonary insults. Despite much work the key mechanisms involved in generating the exaggerated immune response that results in lung injury are not completely understood. Hypoxia-inducible factor-1 has been shown to be a key transcription factor in the myeloid cell response to inflammatory signals. The aims of this thesis were to develop a model of acute lung injury and to study the role of Hif-1 in the generation of lung injury in this model. A model

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31

Ruas, Jorge. "Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1 /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-329-9/.

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32

Groenman, Frederick Anton. "Hypoxia inducible factor a breath of fresh air in lung development /." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10347.

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33

Doedens, Andrew L. "Role of myeloid Hypoxia-Inducible Factor-1alpha in the tumor microenvironment." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3288804.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed June 3, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 52-63).

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Troy, Helen. "Role of Hypoxia-Inducible-Factor-1 (HIF-1) in cancer metabolism." Thesis, St George's, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429907.

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35

Ong, S. G. "The role of hypoxia-inducible factor-1 (HIF-1) in cardioprotection." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1333305/.

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Background - Preconditioning confers strong resistance to ischaemia with strong links to hypoxic-inducible factor-1 (HIF-1) although the exact molecular mechanisms remain unknown. We investigated how HIF-1 might confer cardioprotection through modulation of mitochondrial functions. We also investigated some potential PHD inhibitors as novel therapeutic agents in harnessing HIF-1’s cardioprotective effects. Methods/Results – Preinduction of HIF-1 was achieved by using tamoxifen-inducible cardiacspecific conditional VHL knockout mice in an acute manner as well as using a novel prolyl hydroxylase

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36

Petousi, Nayia. "Functional variation in the hypoxia-inducible factor (HIF) pathway in humans." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:bf340955-5125-422e-befb-b2a7d55a1d39.

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By undertaking a number of different experimental approaches at the genetic, cellular/ molecular and integrative physiology levels, I investigated functional variation in the Hypoxia-Inducible Factor (HIF) transcription pathway in humans. My studies focused on Tibetan natives. Tibetan highlanders are adapted to life in a hypoxic environment and exhibit distinct physiological traits at high altitude. Recent studies identified positive selection at two genetic loci, EPAS1 (HIF2α) and EGLN1 (PHD2), in Tibetan highlanders and demonstrated an association of EGLN1/EPAS1 genotype with haemoglobin con

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37

Yeoh, Kar Kheng. "Studies on the inhibition of human Hypoxia Inducible Factor (HIF) hydroxylases." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558435.

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Hypoxia inducible factor (HIF) is an α/β-heterodimeric transcription factor that regulates cellular responses to hypoxia in metazoans. The activity and stability of the HIF-a subunits are regulated by prolyl and asparaginyl hydroxylation. Human HIF-lα prolyl hydroxylation occurs at Pro402 and Pro564 while asparaginyl hydroxylation occurs at Asn803. Asparaginyl hydroxylation blocks the HIF-la interaction with the p300/CBP eo-activator, thus inhibiting HIF transcriptional activation. Prolyl hydroxylation promotes the HIF-la interaction with the von Hippel-Lindau (VHL) ubiquitin E3 ligase complex

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38

Smythies, James. "Characterising the determinants of hypoxia inducible transcription factors binding to chromatin." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:20fc2f64-a46c-40a0-8e2f-ea0e2d81bd16.

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Hypoxia regulates many hundreds of genes that play important roles in numerous physiological and pathophysiological processes. The hypoxia inducible transcription factors (HIFs) are central to the transcriptional activation of these hypoxia-regulated genes. However, to date, little is known about the determinants of HIF-1 and HIF-2 binding site selection. Both HIF-1 and HIF-2 appear to bind as HIF-α/HIF-1β heterodimers, and recognise the same core consensus DNA motif, the hypoxia response element (HRE). However, each has its own distinct but partially overlapping set of binding sites that acco

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RESMINI, GIULIA. "THE ROLE OF THE HYPOXIA INDUCIBLE FACTOR (HIF-1Α) IN MYOGENESIS". Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/541720.

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Regeneration of skeletal muscle is a complex process that requires the activation of quiescent adult stem cells, the satellite cells, which are resident in hypoxic niches in the tissue. This process is mainly regulated through a group of transcription factors known as the hypoxia-inducible factors (HIFs). In particular, HIF-1α activation has been described as beneficial for the cell to overcome an hypoxic insult, while it has been observed that its chronic activation completely inhibits skeletal muscle differentiation. Therefore, oxygen deprivation and HIF-1α may play a role in activating the

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Ndubuizu, Obinna I. "Oxygen Sensing, Hypoxia Inducible Factor 1 (HIF-1) Expression, and Hypoxia-Induced Angiogenesis in the Aged Rat Brain." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1307746474.

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Schonberger, Robert Brian. "Upregulation of Hypoxia-Inducible Genes in Endothelial Cells to Create Artificial Vasculature." Yale University, 2006. http://ymtdl.med.yale.edu/theses/available/etd-06282006-142557/.

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This study explored the possibility that upregulation of Hypoxia Inducible Factor-1 (Hif-1)-responsive genes in Human Umbilical Vein Endothelial Cells (HUVEC) would promote and stabilize HUVEC formation into inchoate vascular beds within artificial collagen gels. This experiment was designed to explore the above possibility by sub-cloning Hif-1[alpha], the related chimeric construct Hif-1[alpha]/VP16, and the marker gene dsRed into retroviral expression vectors, producing retroviral vectors containing these genes, and stably transducing HUVEC using these retroviruses. Transduced HUVEC were to

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42

Liao, Debbie. "The role of hypoxia inducible factor-1[alpha] in mammary gland tumorigenesis." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3263071.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed April 9, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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Slingo, Mary Elizabeth. "The role of the hypoxia-inducible pathway in metabolism and cardiopulmonary physiology." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:f674808e-6731-49e9-b838-1032875a2ced.

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The research in this thesis investigated the role of the hypoxia-inducible factor (HIF) family of transcription factors in metabolism and cardiopulmonary physiology. Specifically, the effects of HIF on ventilatory control, carotid body morphology, and cardiac metabolism and function were studied using a murine model of a genetic disorder of oxygen sensing known as Chuvash polycythaemia. HIF coordinates oxygen-regulated gene expression throughout all organ systems, thereby orchestrating cellular, tissue and systemic responses to hypoxia. HIF is primarily regulated by oxygen-dependent prolyl hyd

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Lippl, Kerstin. "Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:c5c6fad2-fc75-4c40-933a-b5343f4e1006.

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In humans and other animals, the chronic hypoxic response is mediated by the hypoxia-inducible transcription factors (HIFs), which regulate the expression of genes that counteract the effects of limiting oxygen. HIF prolyl hydroxylases (PHDs) regulate cellular levels and transcriptional activity of HIFs by catalysing the post-translational hydroxylation of conserved prolyl residues in the HIFÎ± subunits. Based on structural and biophysical studies, it has been proposed that the three human PHDs (PHD1-3) act as oxygen sensors, providing a direct link between cellular oxygen availability and th

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45

Wikenheiser, Jamie Christopher. "Altered Hypoxia-Inducible Factor-1 Alpha Levels Correlate with Coronary Artery Anomalies." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1216218122.

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46

MONGIARDI, MARIA PATRIZIA. "Inhibition of telomerase and hypoxia-inducible factor-1 in human glioblastoma multiforme." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/985.

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Il glioblastoma multiforme (GBM), il più comune e aggressivo dei tumori gliali, è composto da una popolazione eterogenea di cellule tumorali astrocitarie scarsamente differenziate. Questi tumori possono svilupparsi dall’evoluzione maligna di un astrocitoma di più basso grado (grado WHO I o II) o da un astrocitoma anaplastico (grado WHO III), ma più frequentemente si manifestano de novo, senza alcuna evidenza di una neoplasia precedente. Il GBM è un tumore paradigmatico nella capacità di indurre neo-angiogenesi, processo necessario per la crescita dei tumori solidi. Le cellule endoteliali del

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47

Perrone, Giulia <1978&gt. "Modulation of hypoxia-inducible factors as a therapeutic target for multiple myeloma." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4701/1/perrone_giulia_tesi.doc.pdf.

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Hypoxia-inducible factor-1 alpha (HIF-1α) plays a critical role in survival and is associated with poor prognosis in solid tumors. The role of HIF-1α in multiple myeloma is not completely known. In the present study, we explored the effect of EZN2968, an locked nucleic acid antisense oligonucleotide against HIF-1α, as a molecular target in MM. A panel of MM cell lines and primary samples from MM patients were cultured in vitro in the presence of EZN2968 . Under normoxia culture condition, HIF-1α mRNA and protein expression was detectable in all MM cell lines and in CD138+ cells from newly

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Perrone, Giulia <1978&gt. "Modulation of hypoxia-inducible factors as a therapeutic target for multiple myeloma." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4701/.

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Hypoxia-inducible factor-1 alpha (HIF-1α) plays a critical role in survival and is associated with poor prognosis in solid tumors. The role of HIF-1α in multiple myeloma is not completely known. In the present study, we explored the effect of EZN2968, an locked nucleic acid antisense oligonucleotide against HIF-1α, as a molecular target in MM. A panel of MM cell lines and primary samples from MM patients were cultured in vitro in the presence of EZN2968 . Under normoxia culture condition, HIF-1α mRNA and protein expression was detectable in all MM cell lines and in CD138+ cells from newly

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Liu, Chun. "The roles of the autonomic nervous system and hypoxia-inducible factor 1 in cardiorespiratory responses to hypoxia in humans." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437183.

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Matsuyama, Tomonori. "Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system." Kyoto University, 2015. http://hdl.handle.net/2433/202803.

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