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Dissertations / Theses on the topic 'Hypoxia'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

O'Dell, Adam David. "Hypoxia." Bowling Green State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1490629987974442.

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2

Chacaroun, Samarmar. "Stratégies thérapeutiques par conditionnement hypoxique : modalités pratiques et effets sur la santé cardio-respiratoire et métabolique." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAS020/document.

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L’hypoxie désigne une baisse de la biodisponibilité en oxygène au niveau tissulaire. La combinaison de l’hypoxie intermittente et de l’hypercapnie est identifiée dans le cadre de plusieurs maladies respiratoires comme un élément physiopathologique déterminant. Cependant, des travaux de recherche suggèrent qu’une exposition à l’hypoxie hypo- ou normocapnique à l’éveil peut améliorer la santé cardiovasculaire. La combinaison d’une exposition hypoxique et de l’entraînement à l’effort est utilisée par les athlètes pour améliorer la performance sportive aérobie. Des études pilotes récentes y compri

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3

Liang, Dinghua. "Progress towards hypoxia-activated SN-38: the potential to target hypoxic tumors." Bentham Science, 2015. http://hdl.handle.net/1993/31591.

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Solid tumors are commonly subject to hypoxia. Hypoxic cancer cells have undesirable properties such as a high tendency to metastasize and resistance to chemotherapy and radiotherapy. Hypoxia-inducible factors (HIFs) respond to the changes in oxygen levels, orchestrating the transcription of many proteins that are vital for the survival of hypoxic cancer cells. With their parent drug SN-38 as an inhibitor of both topoisomerase 1 and HIF-1, hypoxia-activated SN-38s may have a dual inhibitory effect on hypoxic tumor cells due to hypoxia-targeting and HIF-1 inhibition. To develop hypoxia-activa

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4

Peters, Caren Lorraine. "Hypoxia in inflammation." Thesis, University of Bath, 2003. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426151.

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5

Lau, Yue-huen Thomas. "Nuclear transcription factors and hypoxia-inducible genes in chronic liver hypoxia." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31939302.

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6

Lau, Yue-huen Thomas, and 劉汝這. "Nuclear transcription factors and hypoxia-inducible genes in chronic liver hypoxia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31939302.

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7

Fantacci, M. "In vivo distribution of Hypoxia-Inducible Factor-1α and DNA fragmentation in hypoxic tumoral and non-tumoral cells: correlation between chronic hypoxia and apoptosis". Doctoral thesis, Università degli Studi di Milano, 2004. http://hdl.handle.net/2434/154279.

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8

Querido, Jordan S. "Intermittent hypoxia : cardiorespiratory and cerebrovascular consequences to acute hypoxia and submaximal exercise." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/32125.

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Intermittent hypoxia (IH) is broadly defined as repeatedly breathing decreased amounts of oxygen (hypoxia) interspersed with periods of room air breathing (normoxia). In animal, human diseased, and healthy human models, research has shown IH to negatively affect cerebrovascular vessel dilation. We have previously shown poikilocapnic (uncontrolled carbon dioxide (CO₂)) IH to blunt the vasodilatory response of a cerebral vessel during acute hypoxia. The purpose of this study was to measure the ventilatory, cardiovascular and cerebrovascular responses to: I) acute hypoxia and; II) to submaximal

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9

Smith, Quintina Denine. "From here to hypoxia." College Park, Md. : University of Maryland, 2006. http://hdl.handle.net/1903/3614.

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Thesis (M.F.A.) -- University of Maryland, College Park, 2006.<br>Thesis research directed by: Dept. of Art. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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10

Holland, Jason P. "Hypoxia-Selective Copper Radiopharmaceuticals." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491536.

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This thesis presents detailed experimental and computational investigations into the chemistry of copper(II) and zinc(II) bis(thiosemicarbazonato) complexes as potential' radiopharmaceutical agents for imaging and therapy. Chapter 1 provides an introduction to the field of molecular imaging in medicine with particular emphasis on the role of positron emission tomography in oncology. Key aspects of tumour physiology are discussed, and the effects of tumour hypoxia on radiotherapy and chemotherapy are considered. A range of hypoxia-selective radiopharmaceuticals are also introduced including a r

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11

Mahamed, Safraaz. "Chemoreflex adaptations to hypoxia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0019/MQ54186.pdf.

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12

Querido, Jordan Scott. "Hypoxia and autonomic control." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42530.

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Humans have a remarkable ability to cope with and survive exposure to hypoxia. Some have suggested a benefit in certain physiological systems in response to such exposure. However, the physiological response to hypoxia is multifaceted and includes an orchestrated response from many autonomic mechanisms. Thus, the purpose of this thesis was to more fully understand the human autonomic response to hypoxia as an integrated unit. Furthermore, pathological models of hypoxia provide evidence that suggests hypoxia can result in an autonomic response that outlasts the hypoxic stimulus. However, the pe

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13

Nagyova, Beatrix Valeria. "Respiratory effects of hypoxia." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320659.

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14

Dearling, Jason L. J. "Hypoxia targeting copper complexes." Thesis, University of Kent, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297352.

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15

Alotaibi, Mohammed. "An investigation into the effect of hypoxia in the uterus : does hypoxic preconditioning occur?" Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/10833/.

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During labour, the uterus experiences transient and repeated hypoxic episodes as contractions occlude uterine blood vessels. Despite this, uterine contractions are maintained, their strength gradually increases and labour progresses. The effect of repeated episodes of transient hypoxia on uterine contractility has not been previously investigated and in my study I investigate the hypothesis that multiple transient hypoxic episodes can increase the contractile activity in a pregnant rat uterus near term. Uterine strips were dissected and mounted in organ baths, bubbled with Hepes-buffered, oxyg

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16

Lau, Chi-keung, та 劉智強. "Blockade of hypoxia inducible factor-1α sensitizes hepatocellular carcinoma to hypoxia and chemotherapy". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39634243.

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17

Laitala, A. (Anu). "Hypoxia-inducible factor prolyl 4-hydroxylases regulating erythropoiesis, and hypoxia-inducible lysyl oxidase regulating skeletal muscle development during embryogenesis." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526206943.

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Abstract Erythropoiesis is the process of red blood cell production. The main regulator is the erythropoietin (EPO) hormone, which is strongly upregulated in low oxygen concentration (hypoxia) in cells via the hypoxia-inducible transcription factor HIF. The stability of HIF is regulated in an oxygen-dependent manner by three HIF prolyl 4-hydroxylases, all of which are known to participate in the regulation of erythropoiesis. A role in erythropoiesis of a fourth prolyl 4-hydroxylase, P4H-TM, which possesses a transmembrane domain, is not known, but it is able to hydroxylate HIF at least in vitr

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18

Sumner, Stephanie Gillian. "Novel use of oxygen-regulated bacterial transcription factors to target gene expression to solid tumours." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366112.

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19

Dospinescu, Ciprian. "Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins." Thesis, Robert Gordon University, 2009. http://hdl.handle.net/10059/380.

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In the pulmonary circulation, alveolar hypoxia contributes to blood flow regulation. Hypoxic pulmonary vasoconstriction (HPV) involves both pulmonary arteries and veins, but little is known of the contractile mechanisms specific to the veins. The aim of these studies was to examine the hypoxic response in small porcine intrapulmonary veins in relation to the arterial response, and investigate the effects of hypoxia on ion conductances in single myocytes from intrapulmonary veins. In wire myography experiments, intrapulmonary veins contracted more than sizematched arteries in response to hypoxi

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20

Lim, Ta. "The role of hypoxia-inducible factor-1α in xenon preconditioning versus hypoxic-ischaemic organ injury". Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/7663.

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Background: The anaesthetic gas xenon provides long-lasting preservation of neuronal function when given several hours prior to neuronal injury. This phenomenon is described as preconditioning. However, little is known of the mechanisms by which xenon preconditioning mediates its protective effect. Interest has focused on the involvement of hypoxia-inducible factor-1α (HIF-1α) in preconditioning because: (i) Hypoxia activates HIF-1α and is an effective preconditioning stimulus; (ii) HIF-1α is a regulator of adaptive responses promoting cellular survival; (iii) Several genes that have hypoxia-r

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21

Hsieh, Yee-Hsee. "BRAINSTEM GABAA RECEPTOR SHAPE THE RESPONSE AND ADAPTATION TO HYPOXIA." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1184267396.

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22

Lau, Chi-keung. "Blockade of hypoxia inducible factor-1[alpha] sensitizes hepatocellular carcinoma to hypoxia and chemotherapy." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39634243.

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23

Hägg, Maria. "Hypoxia-inducible factors (HIFs) and biological responses in hypoxia, inflammation and embryonic vascular development /." Göteborg: Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, 2008. http://hdl.handle.net/2077/9991.

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24

Nakhlé, Jessica. "Rôle de la thrombospondine-1 dans la migration, l’invasion et la dissémination métastatique dans les carcinomes prostatiques et mammaires." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T088/document.

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Les métastases représentent l’étape ultime de la progression tumorale. Les traitements inhibiteurs de l’angiogenèse offrent de nouvelles perspectives thérapeutiques, notamment pour les stades invasifs, mais cependant ils n’apportent qu’une prolongation modeste de la survie des patients. La faible réponse de certains types de cancers aux traitements ciblant l’angiogenèse tumorale, comme le carcinome de la prostate chez l’homme ou du sein chez la femme, est due au développement de résistances tumorales d’une part, et à l’accélération du processus métastatique mise en évidence par certaines étude

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25

Mordel, Patrick. "Variabilité glycémique : exploration in vitro des fonctions cellulaires et mitochondriales sur la lignée de cardiomyocyte HL-1." Thesis, Normandie, 2017. http://www.theses.fr/2017NORMC415/document.

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Le diabète est associé à une augmentation de risque de maladie cardiovasculaire et une dérégulation du métabolisme. Il a été suggéré que la variabilité glycémique (VG) pouvait avoir un rôle dans le développement des complications du diabète. Afin d’étudier et de caractériser les dysfonctions induites par la VG, nous avons mis au point un modèle in vitro mimant la VG sur la lignée de cardiomyocytes HL-1. Nous avons ainsi développé un traitement de 12 heures, mimant hypoglycémie, normoglycémie, hyperglycémie et VG. L’étude de la signalisation cellulaire ne nous a pas permis de montrer un rôle dé

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26

Wahlquist, Hanna. "Hypoxia and Angiogenesis in IUGR." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9316.

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<p>BACKGROUND: Intrauterine growth restriction (IUGR) is a condition where the infant fails to reach its genetic growth potential due to numerous factors. IUGR foetuses are associated with high perinatal mortality and morbidity. This study investigated if hypoxia might be involved during gestation, and whether if hypoxia may have an impact on the development of the placenta, through regulation of various angiogenic factors, such as HIF-1_, VEGF, PIGF, VEGFR-1 and CD31. METHOD: Each sample of placental tissue was stained by immunohistochemisty for HIF-1_, VEGF, PIGF, VEGFR-1 and CD31. Th

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27

Hobbs, Catherine E., and n/a. "Perinatal hypoxia-ischaemia : neuroprotective strategies." University of Otago. Department of Anatomy & Structural Biology, 2005. http://adt.otago.ac.nz./public/adt-NZDU20070221.145910.

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Perinatal hypoxia-ischaemia is a major cause of disability, including cerebral palsy, yet a neuroprotectant which fully protects the brain remains elusive. Following a hypoxic-ischaemic insult, striatal medium-spiny neurons and hippocampal CA1 neurons are vulnerable to a complex cascade of neurotoxic events. This cascade includes energy failure, a massive release of glutamate, the formation of free radicals and caspase activation. The overall aim of this thesis was to assess the efficacy of three potential neuroprotective strategies that target this cascade from different directions. Short-ter

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28

Raval, Raju R. "Hypoxia-mediated pathways in cancer." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433331.

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29

Talbot, Nicholas. "Pulmonary vascular responses to hypoxia." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404270.

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30

Peansukmanee, Siriporn. "Equine chondrocyte metabolism under hypoxia." Thesis, University of Liverpool, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501589.

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The avascular nature of articular cartilage limits oxygen supply within the tissue. Cartilage, therefore, is under physiological hypoxic conditions. Oxygenation gradients are estimated from 10% at the surface to 1% at the deepest layer. Nonetheless, chondrocytes have been reported to be able to survive and are well-adapted to such an environment. We hypothesised that low oxygen tensions favour chondrocyte metabolism based on their nature and literature reviews.

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31

MacManus, Michael Patrick. "Erthropoietin, anaemia and tumour hypoxia." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335941.

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32

Jones, Richard David. "Hypoxia and the pulmonary circulation." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301608.

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33

Padmanabha, Divya. "HIF-INDEPENDENT RESPONSES IN HYPOXIA." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3828.

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The adaptive response to hypoxia is accompanied by widespread transcriptional changes that allow for prolonged survival in low oxygen. Many of these changes are directly regulated by the conserved hypoxia-inducible factor-1 (HIF-1) complex; however, even in its absence, many oxygen-sensitive transcripts in Caenorhabditis elegans are appropriately regulated in hypoxia. To identify mediators of these non-HIF-dependent responses, I established a hif-1 mutant reporter line that expresses GFP in hypoxia or when worms are treated with the hypoxia mimetic cobalt chloride (cobalt chloride). The report

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34

Lungu, Gina Florentina. "Role of hypoxia and hypoxia induced factors in the development of breast cancer brain metastasis." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3082.

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35

Borecky, Lisa. "Hypoxia-inducible factor-1α and the Control of Hypoxic Ventilatory and Metabolic Responses in Mice and African Naked Mole Rats". Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37908.

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Hypoxia-inducible factors (HIFs) are a highly conserved group of transcriptional regulators responsible for cellular and systemic O2 homeostasis in animals. However, how HIFs are involved in basic adaptive ventilatory and metabolic responses to acute and chronic hypoxia remains incompletely characterized. Naked mole rats are among the most hypoxia tolerant mammals identified. As opposed to the typical hyperventilatory response of most adult mammals, naked mole rats exhibit a unique decline in ventilation, matching their substantial decrease in metabolic rate. Naked mole rats therefore provide

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36

Pawar, Anita. "Intermittent Hypoxia and Neonatal Carotid Body Function." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1237993899.

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37

Anduran, Emilie. "Bioreductive Activated Prodrugs to Target Tumor Hypoxia." Electronic Thesis or Diss., Montpellier, Ecole nationale supérieure de chimie, 2022. https://theses.enscm.fr/ENSCM_2022_ANDURAN.pdf.

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L'hypoxie est une caractéristique bien connue du microenvironnement dans les tumeurs solides, associée à l'agressivité, aux métastases et à un impact négatif sur le pronostic thérapeutique. Les tumeurs hypoxiques sont généralement résistantes à la radiothérapie et à la chimiothérapie. Considérant son rôle central dans la progression tumorale et la résistance au traitement, l'hypoxie tumorale est considérée comme une cible validée à exploiter en oncologie pour développer des outils diagnostiques et thérapeutiques. Les différences significatives entre le microenvironnement hypoxique et les tissu

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38

Huey, Kimberly A. "Time-dependent changes in dopamine D₂-receptor modulation of the hypoxic ventilatory response with chronic hypoxia /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9935485.

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39

Knight, Laura K. "The effect of hypoxia and the transcription factor hypoxia inducible factor-1 (HIF-1) on metastasis." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502269.

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Tumour hypoxia has been widely implicated in the development of aggressive, therapy resistant malignant disease. Patients presenting with more hypoxic tumours experience higher levels of mortality compared to those with lower levels of hypoxia. The primary reason or this increased phenotype is the stabilisation of the transcription factor hypoxia inducible factor-1 (HIF-1). Upon exposure to hypoxic conditions, the alpha subunit of this heterodimer Stabilised and binds to the beta subunit. Once stabilised HIF-1 induces gene expression resulting in the Increased exproression of a number of prote

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40

Lim, Ai Lin. "Characterization of hypoxia-induced gene (HIG2) and hypoxia-inducible autophagy as novel pathways of tumor growth /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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41

Taheem, Dheraj Kumar. "A role for hypoxia and hypoxia inducible factor during chondrogenesis of bone marrow mesenchymal stem cells." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/a-role-for-hypoxia-and-hypoxia-inducible-factor-during-chondrogenesis-of-bone-marrow-mesenchymal-stem-cells(8f516122-6cd6-4c9b-91f6-bede34427fd5).html.

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Articular cartilage lesions cause pain, morbidity and may progress to osteoarthritis, which in terms of medical care, has been approximated to cost 1-2.5% of the gross national product of USA, UK, France and other countries. Current repair strategies have considerable limitations and have prompted the development of cartilage tissue engineering (CTE) approaches. One of the challenges of CTE is the expansion and differentiation of adult stem cells in vitro, into functional articular chondrocytes whilst avoiding hypertrophy. Hypoxia is an important environmental factor required for cartilage dev

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42

Adhami, Faisal. "Differential Adult and Neonatal Response to Cerebral Ischemia-Hypoxia." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196054266.

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43

Otandault, Aviviani Amaelle Cherone. "ADN circulant nucléaire et mitochondrial et étude de l'influence de l'hypoxie sur leur libération." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT011.

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Plusieurs travaux s’accordent sur le fait que l’analyse de l’ADN circulant (ADNcir) est un outil à fort potentiel diagnostic, pronostic, théranostic et de suivi en oncologie clinique. Cependant, le manque de standardisation des procédures pré-analytiques, des connaissances approfondies des structures des ADNcir ainsi que les facteurs influençant la dynamique de son relargage constituent des obstacles à son transfert en pratique clinique. C’est dans ce contexte que nous avons choisi d’approfondir l’étude des structures des ADNcir d’origines nucléaire et mitochondriale, évaluer leur utilité clin

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44

Tan, Qiulin. "Inhibition of cholesterol biosynthesis under hypoxia." Texas A&M University, 2005. http://hdl.handle.net/1969.1/3101.

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Oxygen balance is very important and tightly regulated in mammals. Under hypoxia, hypoxia inducible factor 1(HIF-1) dimerizes with hypoxia inducible factor 1± (HIF-) and activates expression of several genes. Using a mammalian two hybrid assay, we found that HIF-1 interacted with sterol response element binding protein 1a (SREBP1a). SREBP1a regulates transcription of HMG-CoA reductase via binding to the sterol response element (SRE) in the promoter region. HMG-CoA reductase is the rate-limiting enzyme in cholesterol biosynthesis. The interaction between SREBP1a and HIF-1suggests that HIF-1 may

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45

Hoenderdos, Kim. "Modulation of neutrophil degranulation by hypoxia." Thesis, University of Cambridge, 2015. https://www.repository.cam.ac.uk/handle/1810/247459.

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Neutrophils are key effector cells of the innate immune system. They employ a number of powerful ‘weapons’ to eliminate pathogens, including an array of destructive proteins packaged into distinctive granule subsets. In addition to their microbicidal activity, these granule proteins are capable of causing substantial tissue damage if inappropriately deployed. To mitigate against this possibility, most physiological stimuli induce minimal extracellular degranulation. Sites of inflammation and infection are usually hypoxic, and it has been shown that oxygen depletion compromises neutrophil funct

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46

Winter, Stuart Charles Alec. "Hypoxia in head and neck cancer." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428506.

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47

Eckert, Danny Joel. "Hypoxia suppresses sympton perception in asthma /." Title page and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09SB/09sbe1918.pdf.

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48

Sluimer, Judith Christina. "Hypoxia, HIF and angiogenesis in atherosclerosis." Maastricht : Maastricht : Universitaire pers Maastricht ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=10707.

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49

Soo, Catherine Chun-Yan. "Hypoxia in inflammation : potential therapeutic target." Thesis, Queen Mary, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313350.

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50

Li, Jingping, and 李京平. "Role of tissue hypoxia in periodontitis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47849563.

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In periodontitis, local oxygen supply and consumption in gingival tissues may be significantly altered due to the inflammatory process. The etiology agent of periodontal disease i.e. anaerobic bacterial biofilm is known to confer a low oxygen tension in the vicinity of periodontitis lesion. The oxygen shortage will lead to the stabilization of HIF-1α, the regulatory subunit of hypoxia-inducible factor (HIF)-1, which through controlling specific downstream genes transcription may modulate multiple cellular functions and hence shape the process of periodontitis. Lipopolysaccharide (LPS),

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