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Journal articles on the topic 'Hypoxic conditioning'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Camacho-Cardenosa, Marta, Alba Camacho-Cardenosa, Rafael Timón, Guillermo Olcina, Pablo Tomas-Carus, and Javier Brazo-Sayavera. "Can Hypoxic Conditioning Improve Bone Metabolism? A Systematic Review." International Journal of Environmental Research and Public Health 16, no. 10 (2019): 1799. http://dx.doi.org/10.3390/ijerph16101799.

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Among other functions, hypoxia-inducible factor plays a critical role in bone–vascular coupling and bone formation. Studies have suggested that hypoxic conditioning could be a potential nonpharmacological strategy for treating skeletal diseases. However, there is no clear consensus regarding the bone metabolism response to hypoxia. Therefore, this review aims to examine the impact of different modes of hypoxia conditioning on bone metabolism. The PubMed and Web of Science databases were searched for experimental studies written in English that investigated the effects of modification of ambien

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Glazachev, O. S., N. P. Lyamina, and G. K. Spirina. "Intermittent hypoxic conditioning: experience and potential in cardiac rehabilitation programs." Russian Journal of Cardiology 26, no. 5 (2021): 4426. http://dx.doi.org/10.15829/1560-4071-2021-4426.

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The review describes the experience in intermittent hypoxic conditioning protocols in rehabilitation programs for patients with cardiovascular diseases. Based on randomized controlled trials, the efficacy and safety of intermittent hypoxic conditioning in patients with cardiovascular disease, including those with multicomorbidity in clinical practice, have been analyzed. From a physiological and clinical standpoints, the review justifies the need for further controlled clinical trials on hypoxic conditioning with a longer follow-up period both to expand the clinical indications for this method

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Colmone, Angela. "Hypoxic conditioning of immune cells." Science 355, no. 6326 (2017): 706.2–706. http://dx.doi.org/10.1126/science.355.6326.706-b.

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Rosova, Ivana, and Jan A. Nolta. "Hypoxic Preconditioning Results in Increased Motility and Improved Therapeutic Potential of Human Mesenchymal Stem Cells in a Xenograft Hind Limb Ischemia Injury Model." Blood 110, no. 11 (2007): 217. http://dx.doi.org/10.1182/blood.v110.11.217.217.

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Abstract Disorders such as peripheral artery disease cause hypoxic areas in tissues. Work from our group and others shows that stem cells appear to have innate mechanisms to respond to hypoxic conditions by migrating to the region of damage, and releasing trophic factors which initiate regeneration. Many tissues activate hepatocyte growth factor (HGF) as a response to ischemic injury. Multiple progenitor cell types express cMet, an HGF receptor. Mesenchymal stem cells (MSC) have been shown to improve regeneration of injured tissues in vivo, but their mechanisms of homing to the site of injury

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Katayama, Keisho, Yasutake Sato, Yoshifumi Morotome, et al. "Intermittent hypoxia increases ventilation and SaO2 during hypoxic exercise and hypoxic chemosensitivity." Journal of Applied Physiology 90, no. 4 (2001): 1431–40. http://dx.doi.org/10.1152/jappl.2001.90.4.1431.

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The purpose of this study was 1) to test the hypothesis that ventilation and arterial oxygen saturation (SaO2 ) during acute hypoxia may increase during intermittent hypoxia and remain elevated for a week without hypoxic exposure and 2) to clarify whether the changes in ventilation and SaO2 during hypoxic exercise are correlated with the change in hypoxic chemosensitivity. Six subjects were exposed to a simulated altitude of 4,500 m altitude for 7 days (1 h/day). Oxygen uptake (V˙o 2), expired minute ventilation (V˙e), and SaO2 were measured during maximal and submaximal exercise at 432 Torr b

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Burtscher, Johannes, Vittorio Maglione, Alba Di Pardo, Grégoire P. Millet, Christoph Schwarzer, and Luca Zangrandi. "A Rationale for Hypoxic and Chemical Conditioning in Huntington’s Disease." International Journal of Molecular Sciences 22, no. 2 (2021): 582. http://dx.doi.org/10.3390/ijms22020582.

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Neurodegenerative diseases are characterized by adverse cellular environments and pathological alterations causing neurodegeneration in distinct brain regions. This development is triggered or facilitated by conditions such as hypoxia, ischemia or inflammation and is associated with disruptions of fundamental cellular functions, including metabolic and ion homeostasis. Targeting intracellular downstream consequences to specifically reverse these pathological changes proved difficult to translate to clinical settings. Here, we discuss the potential of more holistic approaches with the purpose t

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Burtscher, Johannes, Vittorio Maglione, Alba Di Pardo, Grégoire P. Millet, Christoph Schwarzer, and Luca Zangrandi. "A Rationale for Hypoxic and Chemical Conditioning in Huntington’s Disease." International Journal of Molecular Sciences 22, no. 2 (2021): 582. http://dx.doi.org/10.3390/ijms22020582.

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Neurodegenerative diseases are characterized by adverse cellular environments and pathological alterations causing neurodegeneration in distinct brain regions. This development is triggered or facilitated by conditions such as hypoxia, ischemia or inflammation and is associated with disruptions of fundamental cellular functions, including metabolic and ion homeostasis. Targeting intracellular downstream consequences to specifically reverse these pathological changes proved difficult to translate to clinical settings. Here, we discuss the potential of more holistic approaches with the purpose t

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Almohanna, Asmaa M., and Susan Wray. "Hypoxic conditioning in blood vessels and smooth muscle tissues: effects on function, mechanisms, and unknowns." American Journal of Physiology-Heart and Circulatory Physiology 315, no. 4 (2018): H756—H770. http://dx.doi.org/10.1152/ajpheart.00725.2017.

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Hypoxic preconditioning, the protective effect of brief, intermittent hypoxic or ischemic episodes on subsequent more severe hypoxic episodes, has been known for 30 yr from studies on cardiac muscle. The concept of hypoxic preconditioning has expanded; excitingly, organs beyond the heart, including the brain, liver, and kidney, also benefit. Preconditioning of vascular and visceral smooth muscles has received less attention despite their obvious importance to health. In addition, there has been no attempt to synthesize the literature in this field. Therefore, in addition to overviewing the cur

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Zwemer, Charles F., Michael Y. Song, Katari A. Carello, and Louis G. D'Alecy. "Strain differences in response to acute hypoxia: CD-1 versus C57BL/6J mice." Journal of Applied Physiology 102, no. 1 (2007): 286–93. http://dx.doi.org/10.1152/japplphysiol.00536.2006.

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Some mammals respond to hypoxia by lowering metabolic demand for oxygen and others by maximizing efficiency of oxygen usage: the former strategy is generally held to be the more effective. We describe within the same species one outbred strain (CD-1) that lowers demand and another inbred strain (C57BL/6J) that maximizes oxygen efficiency to markedly extend hypoxic tolerance. Unanesthetized adult male mice ( Mus musculus, CD-1 and C57BL/6J) between 20 and 35 g were used. Sham-conditioned (SC) C57BL/6J mice survived severe hypoxia (4.5% O2, balance N2) roughly twice as long as SC CD-1 mice (medi

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Gallego, J., and P. Perruchet. "Classical conditioning of ventilatory responses in humans." Journal of Applied Physiology 70, no. 2 (1991): 676–82. http://dx.doi.org/10.1152/jappl.1991.70.2.676.

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A classical conditioning experiment, in which an auditory stimulus was paired with a hypoxic stimulus, was carried out on 34 normal subjects assigned to two groups (experimental and control). Each subject took part in one session divided into two phases, acquisition and test. In the acquisition phase, eight hypoxic and eight auditory stimuli were paired in the experimental group and unpaired in the control group. In the test phase, which was identical for the two groups, the hypoxic stimuli were suppressed and three purely auditory stimuli were presented. Significant differences between the tw

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Rybnikova, Elena, and Natalia Nalivaeva. "Glucocorticoid-Dependent Mechanisms of Brain Tolerance to Hypoxia." International Journal of Molecular Sciences 22, no. 15 (2021): 7982. http://dx.doi.org/10.3390/ijms22157982.

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Adaptation of organisms to stressors is coordinated by the hypothalamic-pituitary-adrenal axis (HPA), which involves glucocorticoids (GCs) and glucocorticoid receptors (GRs). Although the effects of GCs are well characterized, their impact on brain adaptation to hypoxia/ischemia is still understudied. The brain is not only the most susceptible to hypoxic injury, but also vulnerable to GC-induced damage, which makes studying the mechanisms of brain hypoxic tolerance and resistance to stress-related elevation of GCs of great importance. Cross-talk between the molecular mechanisms activated in ne

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Chacaroun, Samarmar, Anna Borowik, Stephane Doutreleau, et al. "Cardiovascular and metabolic responses to passive hypoxic conditioning in overweight and mildly obese individuals." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 319, no. 2 (2020): R211—R222. http://dx.doi.org/10.1152/ajpregu.00311.2019.

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Although severe intermittent hypoxia (IH) is well known to induce deleterious cardiometabolic consequences, moderate IH may induce positive effects in obese individuals. The present study aimed to evaluate the effect of two hypoxic conditioning programs on cardiovascular and metabolic health status of overweight or obese individuals. In this randomized single-blind controlled study, 35 subjects (54 ± 9.3 yr, 31.7 ± 3.5 kg/m2) were randomized into three 8-wk interventions (three 1-h sessions per week): sustained hypoxia (SH), arterial oxygen saturation ([Formula: see text]) = 75%; IH, 5 min [Fo

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Baker, J. A., and M. S. Davis. "Effect of conditioning on exercise-induced hyperthermia and post-exercise cooling in dogs." Comparative Exercise Physiology 14, no. 2 (2018): 91–97. http://dx.doi.org/10.3920/cep170039.

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Our objective was to evaluate the effect of conditioning and hypoxia on rectal and gastrointestinal temperature changes in dogs exercising at cold ambient temperature. Six Alaskan Husky sled dogs, each in a physically conditioned and unconditioned state, were used in the prospective study. Dogs in peak physical condition were run untethered on a treadmill under normoxic and hypoxic conditions of 20 and 12.5% environmental oxygen concentration, respectively, on separate days. After undergoing a deconditioning period of four months, the same dogs were run again under the same environmental condi

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Klug, Lars, Anja Mähler, Natalia Rakova, et al. "Normobaric hypoxic conditioning in men with metabolic syndrome." Physiological Reports 6, no. 24 (2018): e13949. http://dx.doi.org/10.14814/phy2.13949.

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15

Dempsey, E. C., I. F. McMurtry, and R. F. O'Brien. "Protein kinase C activation allows pulmonary artery smooth muscle cells to proliferate to hypoxia." American Journal of Physiology-Lung Cellular and Molecular Physiology 260, no. 2 (1991): L136—L145. http://dx.doi.org/10.1152/ajplung.1991.260.2.l136.

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Pulmonary artery (PA) smooth muscle cell (SMC) proliferation occurs with hypoxic pulmonary hypertension in vivo. However, proliferation of cultured PA SMC to hypoxia has not been demonstrated, and thus the mechanism by which these cells respond to hypoxia is unknown. Because protein kinase C (PKC) plays a role in intracellular transduction of proliferative signals, we asked whether PKC activation 1) causes proliferation of bovine PA SMC and 2) is important in PA SMC proliferative response to hypoxia. By measuring [3H]thymidine incorporation and cell counts, we found that quiescent PA SMC from

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Mallet, Robert T., Eugenia B. Manukhina, Steven Shea Ruelas, James L. Caffrey, and H. Fred Downey. "Cardioprotection by intermittent hypoxia conditioning: evidence, mechanisms, and therapeutic potential." American Journal of Physiology-Heart and Circulatory Physiology 315, no. 2 (2018): H216—H232. http://dx.doi.org/10.1152/ajpheart.00060.2018.

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The calibrated application of limited-duration, cyclic, moderately intense hypoxia-reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These intermittent hypoxic conditioning (IHC) programs consistently produce striking reductions in myocardial infarction and ventricular tachyarrhythmias after coronary artery occlusion and reperfusion and, in many cases, improve contractile function and coronary blood flow. These IHC protocols are fundamentally different from those used to simulate sleep apnea, a recognized cardiovascular risk factor. In clinical studies, IHC improved ex

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Song, Michael Y., Charles F. Zwemer, Steven E. Whitesall, and Louis G. D'Alecy. "Acute and conditioned hypoxic tolerance augmented by endothelial nitric oxide synthase inhibition in mice." Journal of Applied Physiology 102, no. 2 (2007): 610–15. http://dx.doi.org/10.1152/japplphysiol.00894.2006.

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To identify a possible role for nitric oxide (NO) in acute hypoxic tolerance (HT) we measured hypoxic survival time (HST), effect of hypoxic conditioning (HC), and survival following hypoxic conditioning while blocking or mimicking the action of nitric oxide synthase (NOS). To inhibit NOS, CD-1 mice were given supplemental endogenous NOS inhibitor asymmetrical dimethylarginine (ADMA) or a synthetic NOS inhibitor Nω-nitro-l-arginine (l-NNA), both of which nonselectively inhibit three of the isoforms of NOS [inducible (iNOS), neuronal (nNOS), and endothelial NOS (eNOS)]. ADMA (10 mg/kg ip) or sa

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Ryou, Myoung-Gwi, Jie Sun, Kevin N. Oguayo, Eugenia B. Manukhina, H. Fred Downey, and Robert T. Mallet. "Hypoxic Conditioning Suppresses Nitric Oxide Production upon Myocardial Reperfusion." Experimental Biology and Medicine 233, no. 6 (2008): 766–74. http://dx.doi.org/10.3181/0710-rm-282.

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Mayfield, K. P., E. J. Hong, K. M. Carney, and L. G. D'Alecy. "Potential adaptations to acute hypoxia: Hct, stress proteins, and set point for temperature regulation." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 266, no. 5 (1994): R1615—R1622. http://dx.doi.org/10.1152/ajpregu.1994.266.5.r1615.

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Severe, intermittent hypoxia (hypoxic conditioning, HC) increases survival time during subsequent lethal hypoxia in mice. This protective effect was blocked by naloxone, suggesting an opioid-dependent mechanism. We proposed and evaluated three potential mechanisms of this acute adaptation: 1) increased hematocrit (Hct), 2) protein synthesis, and 3) decreased set point for temperature regulation (set point). Increased hematocrit is a well-studied adaptation to chronic hypoxia and could be acutely initiated by sympathetically mediated splenic contraction. Survival during stress can be prolonged

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Sameshima, Hiroshi, and Tsuyomu Ikenoue. "Hypoxic-Ischemic Neonatal Encephalopathy: Animal Experiments for Neuroprotective Therapies." Stroke Research and Treatment 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/659374.

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Hypoxic-ischemic neonatal encephalopathy and ensuing brain damage is still an important problem in modern perinatal medicine. In this paper, we would like to share some of the results of our recent studies on neuroprotective therapies in animal experiments, as well as some literature reviews. From the basic animal studies, we have now obtained some possible candidates for therapeutic measures against hypoxic-ischemic neonatal encephalopathy. For example, they are hypothermia, rehabilitation, free radical scavenger, neurotrophic factors and growth factors, steroid, calcium channel blocker, vaga

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Hasseldam, Henrik, Jacob Hansen-Schwartz, Nina Munkholm, Jack Hou, and Flemming F. Johansen. "Remote post-conditioning reduces hypoxic damage early after experimental stroke." Neurological Research 35, no. 4 (2013): 336–43. http://dx.doi.org/10.1179/1743132812y.0000000130.

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Sprick, Justin D., Robert T. Mallet, Karin Przyklenk, and Caroline A. Rickards. "Ischaemic and hypoxic conditioning: potential for protection of vital organs." Experimental Physiology 104, no. 3 (2019): 278–94. http://dx.doi.org/10.1113/ep087122.

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Butt, Umer Javed, Imam Hassouna, Laura Fernandez Garcia-Agudo та ін. "CaMKIIα Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge". International Journal of Molecular Sciences 22, № 6 (2021): 3164. http://dx.doi.org/10.3390/ijms22063164.

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We previously introduced the brain erythropoietin (EPO) circle as a model to explain the adaptive ‘brain hardware upgrade’ and enhanced performance. In this fundamental circle, brain cells, challenged by motor-cognitive tasks, experience functional hypoxia, triggering the expression of EPO among other genes. We attested hypoxic cells by a transgenic reporter approach under the ubiquitous CAG promoter, with Hif-1α oxygen-dependent degradation-domain (ODD) fused to CreERT2-recombinase. To specifically focus on the functional hypoxia of excitatory pyramidal neurons, here, we generated CaMKIIα-Cre

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Hetzler, Ronald K., Christopher D. Stickley, Iris F. Kimura, et al. "The Effect of Dynamic Intermittent Hypoxic Conditioning on Arterial Oxygen Saturation." Wilderness & Environmental Medicine 20, no. 1 (2009): 26–32. http://dx.doi.org/10.1580/08-weme-or-218.1.

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Yao, Qiao-Ling, Mei-Fen Zhang, Chu-Huai Wang, et al. "Protective effects of early hypoxic post-conditioning in cultured cortical neurons." Brain Injury 25, no. 6 (2011): 604–13. http://dx.doi.org/10.3109/02699052.2011.568035.

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Järlestedt, Katarina, Alison L. Atkins, Henrik Hagberg, Marcela Pekna, and Carina Mallard. "Trace Fear Conditioning Detects Hypoxic-Ischemic Brain Injury in Neonatal Mice." Developmental Neuroscience 33, no. 3-4 (2011): 222–30. http://dx.doi.org/10.1159/000329710.

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Timon, Rafael, Ismael Martínez-Guardado, Alba Camacho-Cardeñosa, Jose M. Villa-Andrada, Guillermo Olcina, and Marta Camacho-Cardeñosa. "Effect of intermittent hypoxic conditioning on inflammatory biomarkers in older adults." Experimental Gerontology 152 (September 2021): 111478. http://dx.doi.org/10.1016/j.exger.2021.111478.

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Hill, Justin, and John Cave. "Targeting the vasculature to improve neural progenitor transplant survival." Translational Neuroscience 6, no. 1 (2015): 162–67. http://dx.doi.org/10.1515/tnsci-2015-0016.

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AbstractNeural progenitor transplantation is a promising therapeutic option for several neurological diseases and injuries. In nearly all human clinical trials and animal models that have tested this strategy, the low survival rate of progenitors after engraftment remains a significant challenge to overcome. Developing methods to improve the survival rate will reduce the number of cells required for transplant and will likely enhance functional improvements produced by the procedure. Here we briefly review the close relationship between the blood vasculature and neural progenitors in both the

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Thomas, A. J., W. Austin, L. Friedman, and K. P. Strohl. "A model of ventilatory instability induced in the unrestrained rat." Journal of Applied Physiology 73, no. 4 (1992): 1530–36. http://dx.doi.org/10.1152/jappl.1992.73.4.1530.

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A classic conditioning paradigm was used to examine the hypothesis that perturbations during sleep in the neonate rat can have a lasting impact on breathing. During the first 4 wk of life, stimuli were presented to rats during behaviorally defined sleep. In a conditioned hypoxic (CH) group, brief periods of hypoxic gas were used as the unconditioned stimulus. Tactile and auditory stimuli were used as the conditioned stimuli. In a conditioned control (CC) group, air was used as the unconditioned stimulus. A third group of unconditioned control (UC) rats was not exposed to the conditioning parad

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Peng, Ying-Jie, and Nanduri R. Prabhakar. "Reactive oxygen species in the plasticity of respiratory behavior elicited by chronic intermittent hypoxia." Journal of Applied Physiology 94, no. 6 (2003): 2342–49. http://dx.doi.org/10.1152/japplphysiol.00613.2002.

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Long-term facilitation (LTF) of breathing elicited by episodic hypoxia (EH) is an extensively studied example of plasticity of respiratory motor behavior. Previous studies employed the paradigm of EH wherein each episode of hypoxia was 5 min. This paradigm is rarely encountered in nature. Brief episodes of hypoxia are encountered frequently with recurrent apneas, wherein hypoxic episodes last a few seconds only. Recent studies suggest that chronic intermittent hypoxia (CIH) represents a form of oxidative stress involving reactive O2species. The objectives of the present study were to determine

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Nowaczyk, Magdalena, Agnieszka Malcher, Agnieszka Zimna, et al. "Addition of Popular Exogenous Antioxidant Agent, PBN, to Culture Media May Be an Important Step to Optimization of Myogenic Stem/Progenitor Cell Preparation Protocol." Antioxidants 10, no. 6 (2021): 959. http://dx.doi.org/10.3390/antiox10060959.

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The aim of the study was to modify human skeletal muscle-derived stem/progenitor cells (SkMDS/PCs) and demonstrate the optimal cell preparation protocol for application in post-infarction hearts. We used conditioned SkMDS/PC culture medium with α-phenyl-N-tert-butyl nitrone (PBN). SkMDS/PCs were cultured under hypoxic conditions and the results were compared to the standard ones. We observed a significant increase of CD-56 positive phenotypic marker the ability to form functional myotubes, increase in the proportion of young cells in cell primary suspensions, and a decrease in the percentage o

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Khankevich, Yu R., K. V. Sapozhnikov, S. A. Parfenov, and A. V. Sedov. "EVALUATION OF THE EFFECTIVENESS OF HYPOXIC CONDITIONING IN PSYCHOPHYSIOLOGICAL TRAINING OF SUBMARINERS." Marine Medicine 2, no. 1 (2016): 57–63. http://dx.doi.org/10.22328/2413-5747-2016-2-1-57-63.

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Efimenko, Anastasia, Ekaterina Starostina, Natalia Kalinina, and Alexandra Stolzing. "Angiogenic properties of aged adipose derived mesenchymal stem cells after hypoxic conditioning." Journal of Translational Medicine 9, no. 1 (2011): 10. http://dx.doi.org/10.1186/1479-5876-9-10.

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Alekseeva, T. M., P. D. Kovzelev, M. P. Topuzova, T. V. Sergeeva, and P. P. Tregub. "Hypercapnic-hypoxic respiratory training as a method of post-conditioning in stroke suvivors." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 25, no. 2 (2019): 134–42. http://dx.doi.org/10.18705/1607-419x-2019-25-2-134-142.

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The paper summarizes data on the use of respiratory training under hypoxia, features of permissive hypercapnia, and the potential mechanisms of neuroprotective effect in the combined use of hypoxia and hypercapnia. The paper provides information about the practical application of this training in various diseases. The technical aspects, the possibility of using individual respiratory simulators, the optimal parameters of exposure and the composition of the gas are discussed. Considering the expected effectiveness we assume that this type of respiratory training can be used in the routine medic

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Webb, K. A., L. A. Wolfe, and M. J. McGrath. "Effects of acute and chronic maternal exercise on fetal heart rate." Journal of Applied Physiology 77, no. 5 (1994): 2207–13. http://dx.doi.org/10.1152/jappl.1994.77.5.2207.

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Maternal-fetal effects of cycle ergometer conditioning (heart rate of 145 beats/min at 25 min/day for 3 days/wk) were studied during the second and third pregnancy trimesters. Subjects were 22 previously sedentary women and 16 nonexercising pregnant control women. Fetal heart rate (FHR) characteristics were studied before, during, and after 15 min of upright cycling at a maternal heart rate target of 145 beats/min at the end of both the second and third trimesters. Despite higher cycling power outputs in the exercised group, mean FHR responses were similar in both groups and conformed to 1) gr

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Tantingco, Genell, and Myoung-Gwi Ryou. "Normobaric intermittent hypoxic training regulates microglia phenotype and enhances phagocytic activity." Experimental Biology and Medicine 245, no. 8 (2020): 740–47. http://dx.doi.org/10.1177/1535370220919361.

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The microglia are the resident immune cells in the central nerve system. In the various pathological conditions, prolonged activated microglia could deteriorate brain damage. The regulation of the microglia polarization should be considered in developing an intervention for ischemic stroke patients. Normobaric intermittent hypoxic training protects the brain from intensive ischemic stresses. This study examined the role of intermittent hypoxic training in the regulation of microglia polarization that occurs in the in vitro model of oxygen–glucose deprivation (OGD)–reoxygenation. EOC20 were ass

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Hsiao, Sarah T., Zerina Lokmic, Hitesh Peshavariya, et al. "Hypoxic Conditioning Enhances the Angiogenic Paracrine Activity of Human Adipose-Derived Stem Cells." Stem Cells and Development 22, no. 10 (2013): 1614–23. http://dx.doi.org/10.1089/scd.2012.0602.

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Shu, Yi, Shivali M. Patel, Chen Pac-Soo, et al. "Xenon Pretreatment Attenuates Anesthetic-induced Apoptosis in the Developing Brain in Comparison with Nitrous Oxide and Hypoxia." Anesthesiology 113, no. 2 (2010): 360–68. http://dx.doi.org/10.1097/aln.0b013e3181d960d7.

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Background Administration of certain general anesthetics to rodents during the synaptogenic phase of neurodevelopment produces neuronal injury. Preconditioning (pretreatment) can reduce tissue injury caused by a severe insult; the authors investigated whether pretreatment strategies can protect the developing brain from anesthetic-induced neurotoxicity. Methods Seven-day-old Sprague-Dawley rats were pretreated with one of the following: 70% xenon, 70% nitrous oxide, or 8% hypoxia for 2 h; 24 h later, rats were exposed to the neurotoxic combination of 70% nitrous oxide and 0.75% isoflurane for

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Mandic, Milica, Carol Best та Steve F. Perry. "Loss of hypoxia-inducible factor 1α affects hypoxia tolerance in larval and adult zebrafish ( Danio rerio )". Proceedings of the Royal Society B: Biological Sciences 287, № 1927 (2020): 20200798. http://dx.doi.org/10.1098/rspb.2020.0798.

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The coordination of the hypoxic response is attributed, in part, to hypoxia-inducible factor 1α (Hif-1α), a regulator of hypoxia-induced transcription. After the teleost-specific genome duplication, most teleost fishes lost the duplicate copy of Hif-1α, except species in the cyprinid lineage that retained both paralogues of Hif-1α (Hif1aa and Hif1ab). Little is known about the contribution of Hif-1α, and specifically of each paralogue, to hypoxia tolerance. Here, we examined hypoxia tolerance in wild-type (Hif1aa +/+ ab +/+ ) and Hif-1α knockout lines (Hif1aa −/− ; Hif1ab −/− ; Hif1aa −/− ab −

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Andrade, André Cronemberger, Martin Wolf, Heide-Marie Binder, et al. "Hypoxic Conditions Promote the Angiogenic Potential of Human Induced Pluripotent Stem Cell-Derived Extracellular Vesicles." International Journal of Molecular Sciences 22, no. 8 (2021): 3890. http://dx.doi.org/10.3390/ijms22083890.

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Stem cells secrete paracrine factors including extracellular vesicles (EVs) which can mediate cellular communication and support the regeneration of injured tissues. Reduced oxygen (hypoxia) as a key regulator in development and regeneration may influence cellular communication via EVs. We asked whether hypoxic conditioning during human induced pluripotent stem cell (iPSC) culture effects their EV quantity, quality or EV-based angiogenic potential. We produced iPSC-EVs from large-scale culture-conditioned media at 1%, 5% and 18% air oxygen using tangential flow filtration (TFF), with or withou

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Xue, Hang, Ying Xu, Shuo Wang, et al. "Sevoflurane post-conditioning alleviates neonatal rat hypoxic-ischemic cerebral injury via Ezh2-regulated autophagy." Drug Design, Development and Therapy Volume 13 (May 2019): 1691–706. http://dx.doi.org/10.2147/dddt.s197325.

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Downey, H. F., X. Shi, V. V. Aleksandrin, A. V. Goryacheva, and E. B. Manukhina. "Beneficial effects of intermittent hypoxic conditioning on cerebral circulation and prevention of cerebrovascular disorders." CardioSomatics 6, no. 1-1 (2015): 26–27. http://dx.doi.org/10.26442/cs45332.

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Hobbins, L., S. Hunter, N. Gaoua, and O. Girard. "Normobaric hypoxic conditioning to maximize weight loss and ameliorate cardio-metabolic health in obese populations: a systematic review." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 313, no. 3 (2017): R251—R264. http://dx.doi.org/10.1152/ajpregu.00160.2017.

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Normobaric hypoxic conditioning (HC) is defined as exposure to systemic and/or local hypoxia at rest (passive) or combined with exercise training (active). HC has been previously used by healthy and athletic populations to enhance their physical capacity and improve performance in the lead up to competition. Recently, HC has also been applied acutely (single exposure) and chronically (repeated exposure over several weeks) to overweight and obese populations with the intention of managing and potentially increasing cardio-metabolic health and weight loss. At present, it is unclear what the card

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Muza, Stephen, Charles Fulco, Beth Beidleman, et al. "Lowlander Time-Trial Performance At 4300m Is Not Improved Following Normobaric Intermittent Hypoxic Exposure Conditioning." Medicine & Science in Sports & Exercise 40, Supplement (2008): S169. http://dx.doi.org/10.1249/01.mss.0000322199.81722.7a.

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Mori, Masatake, Toru Kinugawa, Akihiro Endo, et al. "EFFECTS OF HYPOXIC EXERCISE CONDITIONING ON WORK CAPACITY, LACTATE, HYPOXANTHINE AND HORMONAL FACTORS IN MEN." Clinical and Experimental Pharmacology and Physiology 26, no. 4 (1999): 309–14. http://dx.doi.org/10.1046/j.1440-1681.1999.03034.x.

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DerSarkissian, S., M. Vu, M. Borie, et al. "A NOVEL CONDITIONING AGENT STIMULATES STEM CELLS ACTIVITY AND VIABILITY TO HYPOXIC AND OXIDATIVE STRESSES." Canadian Journal of Cardiology 31, no. 10 (2015): S76—S77. http://dx.doi.org/10.1016/j.cjca.2015.07.172.

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Lukowiak, K., E. Ringseis, G. Spencer, W. Wildering, and N. Syed. "Operant conditioning of aerial respiratory behaviour in Lymnaea stagnalis." Journal of Experimental Biology 199, no. 3 (1996): 683–91. http://dx.doi.org/10.1242/jeb.199.3.683.

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In this study, we operantly conditioned the aerial respiratory behaviour of the freshwater snail Lymnaea stagnalis. Aerial respiration in Lymnaea stagnalis is accomplished by the spontaneous opening and closing of its respiratory orifice, the pneumostome, at the water surface. Weak tactile stimulation of the pneumostome area, when the pneumostome is open, evoked only the pneumostome closure response, which is one aspect of the escape-withdrawal reflex. Pneumostome stimulation resulted in its closure and the termination of aerial respiratory activity. A contingent tactile stimulation paradigm w

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Zhou, Bin, Shaoqing Lei, Rui Xue, Yan Leng, Zhengyuan Xia, and Zhong-Yuan Xia. "DJ-1 overexpression restores ischaemic post-conditioning-mediated cardioprotection in diabetic rats: role of autophagy." Clinical Science 131, no. 11 (2017): 1161–78. http://dx.doi.org/10.1042/cs20170052.

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IPO (ischaemic post-conditioning) is a promising method of alleviating myocardial IR (ischaemia-reperfusion) injury; however, IPO-mediated cardioprotection is lost in diabetic hearts via mechanisms that remain largely unclear. We hypothesized that decreased cardiac expression of DJ-1, a positive modulator of autophagy, compromises the effectiveness of IPO-induced cardioprotection in diabetic rats. Diabetic rats subjected to myocardial IR (30 min of coronary artery occlusion followed by 120 min of reperfusion) exhibited more severe myocardial injury, less cardiac autophagy, lower DJ-1 expressio

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López-Ramos, J. C., P. J. Yi, L. Eleore, N. Madroñal, A. Rueda, and J. M. Delgado-García. "Classical eyeblink conditioning during acute hypobaric hypoxia is improved in acclimatized mice and involves Fos expression in selected brain areas." Journal of Applied Physiology 103, no. 5 (2007): 1479–87. http://dx.doi.org/10.1152/japplphysiol.00384.2007.

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This work attempts to evaluate the cognitive aspects of the acclimatization ability of mice submitted to simulated altitude. Critical altitudes were detected by evaluating open field activity, combined or not with object recognition tasks, at different acute simulated altitudes. Results showed impaired cognitive abilities at ≈3,733 m and above. To evaluate acclimatization capabilities, mice submitted to hypobaric hypoxia at ≈5,000 m for 1 wk were tested for learning and memory performances with classical eyeblink conditioning at the same altitude or at land altitude. Results showed total accli

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Manukhina, Eugenia B., Vadim E. Tseilikman, Marina N. Karpenko, et al. "Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain." International Journal of Molecular Sciences 21, no. 1 (2020): 345. http://dx.doi.org/10.3390/ijms21010345.

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Posttraumatic stress disorder (PTSD) causes mental and somatic diseases. Intermittent hypoxic conditioning (IHC) has cardio-, vaso-, and neuroprotective effects and alleviates experimental PTSD. IHC’s ability to alleviate harmful PTSD effects on rat heart, liver, and brain was examined. PTSD was induced by 10-day exposure to cat urine scent (PTSD rats). Some rats were then adapted to 14-day IHC (PTSD+IHC rats), while PTSD and untreated control rats were cage rested. PTSD rats had a higher anxiety index (AI, X-maze test), than control or PTSD+IHC rats. This higher AI was associated with reduced

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