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Journal articles on the topic 'Hypoxic-ischemic CNS'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Sorokovikova, T. V., L. V. Chichanovskaya, T. V. Menshikova, et al. "Current concepts of hypoxic-ischemic CNS lesions." Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery), no. 6 (May 28, 2025): 742–51. https://doi.org/10.33920/med-01-2506-04.

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Hypoxic-ischemic lesions occur in premature and preterm infants and lead to disorders of the central nervous system, with the main cause of this condition being perinatal asphyxia. Modern statistical data indicate that approximately every second newborn with systemic hypoxia in the perinatal period has morphofunctional CNS disorders. Currently, asphyxia is the third most common cause of neonatal mortality, with prematurity and severe infectious diseases ranking first and second. Hypoxic-ischemic encephalopathy occurring in the neonatal period causes abnormalities in the development of the nerv

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Abdullayeva, G., S. Batyrkhanov, and M. Abdullaeva. "Indicators of psychomotor development of premature infants by perinatal CNS lesion." European Psychiatry 64, S1 (2021): S757. http://dx.doi.org/10.1192/j.eurpsy.2021.2006.

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IntroductionThe birth premature babies with hypoxic-ischemic damage to the neutral system with the subsequent development of hypoxic encephalopathy (HIE). Monitoring of the mental development and neurological status of such prematurely born children is carried out taking into account the corrected age and traditional scales.ObjectivesTo compare indicators of psychomotor development in preterm infants (gestational age < 32 weeks) with and without hypoxic-ischemic encephalopathy.MethodsA prospective study was carried out in the neurological department. The study included data from infants wit

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Kravchenko, L. V., M. A. Levkovich, S. B. Berezhanskaya, et al. "Clinical and immunological criteria for prediction of thechronic course of cytomegalovirus infection on the background of hypoxic-ischemic damage of the central nervous system in children in the first year of life." HIV Infection and Immunosuppressive Disorders 14, no. 3 (2022): 35–42. http://dx.doi.org/10.22328/2077-9828-2022-14-3-35-42.

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Objective. To develop prognostic criteria for the chronic course of cytomegalovirus infection by studying disorders of the regulation of the immune response in children of the first year of life against the background of hypoxic-ischemic CNS damage.Materials and methods. 108 newborns with cytomegalovirus infection occurring against the background of perinatal hypoxicischemic lesions of the central unequal system were examined. All observed patients at 1 and 3 months of life conducted an immunological examination, including the determination of T and B-lymphocytes. Determination of the populati

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Saidovich, Ergashev Suxrob, Mamurova Mavludaxon Mirxamzayevna, and Turayev Bobir Temirpulotovich. "CLINICAL-NEUROPHYSIOLOGICAL AND MORPHOLOGICAL STUDIES OF CHILDREN WITH CONSEQUENCES OF HYPOXIC." Journal of Medical Genetics and Clinical Biology 2, no. 2 (2025): 117–25. https://doi.org/10.61796/jmgcb.v2i2.1214.

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Objective: The problem of perinatal brain injury of hypoxic-ischemic genesis remains a critical issue, with a focus on its high mortality rates, significant disability, and impact on neuropsychic and somatic development in children. These injuries lead to difficulties in social adaptation, diagnosis, and treatment. Methods: The study aims to explore current therapeutic measures applied to children with perinatal hypoxic-ischemic damage to the central nervous system (CNS), evaluating their effectiveness in addressing these challenges. Various medical and social factors are examined to understan

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Aleksandrov, A. G., and D. V. Blinov. "Blood-brain barrier breach after acute cerebral hypoxia in infants." Rehabilitology 2, no. 1 (2024): 107–14. http://dx.doi.org/10.17749/2949-5873/rehabil.2024.13.

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Background. Neuronal lesion, including hypoxic-ischemic damage to the central nervous system (CNS) in perinatal period, leads to the release of neuron-specific enolase (NSE) into peripheral bloodstream. Consequently, NSE can be considered as a biological marker of nervous system injury. Based on NSE level analysis, timely rehabilitation for newborns can be provided, thereby reducing the likelihood of complications associated with CNS injury.Objective: retrospective assessment of NSE level in peripheral blood over a 24-week period in infants of different gestational age with perinatal hypoxic-i

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Petrashenko, Viktoria A., Andrii M. Loboda, Olexandr I. Smiyan, et al. "LABORATORY CRITERIA OF PERINATAL DAMAGE OF CENTRAL NERVOUS SYSTEM AT PREMATURE NEWBORNS." Wiadomości Lekarskie 72, no. 8 (2019): 1512–16. http://dx.doi.org/10.36740/wlek201908118.

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Introduction: Fetal and neonatal hypoxia takes a special place among the damaging factors of central nervous system (CNS). All forms of oxygen deficiency are accompanied by the development of bioenergetic hypoxia, which leads to tension of metabolic processes of the organism. Metabolic effect of hypoxia includes stark reduce of mitochondrial activity due to a significant inhibition enzymes of the Krebs cycle: succinate dehydrogenase (SDH) and lactate dehydrogenase (LDH). In newborn babies is not always possible to objectively assess the condition of the CNS defeat, because very often the sever

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Cherniavska, Yu I., V. I. Pokhylko, O. Ye Akimov, S. M. Tsvirenko, and O. V. Yakovenko. "PROFILE OF NITRIC OXIDE METABOLISM INDICATORS IN PRETERM INFANTS WITH PERINATAL CENTRAL NERVOUS SYSTEM INJURIES." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 23, no. 4 (2023): 50–55. http://dx.doi.org/10.31718/2077-1096.23.4.50.

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Introduction. Premature infants often experience a heightened risk of brain damage, potentially leading to various disorders affecting motor, cognitive, behavioral, social, and sensory functions. The underlying pathological processes of hypoxic-ischemic central nervous system (CNS) injury predominantly stem from compromised cerebral blood flow and oxygen transport. Timely diagnosis and treatment options for prematurely born children with perinatal CNS damage remain limited. Nitric oxide, a universal regulator of physiological functions, plays a crucial role. Endothelial dysfunction, marked by

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Sorokovikova, T. V., A. M. Morozov, K. A. Aleksanyan, Yu I. Kovalchuk, and V. V. Frolova. "Epileptic seizures caused by hypoxic-ischemic damage to the central nervous system." Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery), no. 1 (January 19, 2024): 111–19. http://dx.doi.org/10.33920/med-01-2401-11.

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Epilepsy is a chronic disease of the brain. There are many risk factors and causes of this disease, but it is known that the peak incidence occurs in the first year of a child's life. This is due to the fact that this pathology in most cases is the outcome of perinatal damage to the central nervous system (CNS), which has a hypoxic-ischemic genesis. Hemodynamic disturbances that occur in hypoxia lead to various metabolic shifts, which is subsequently accompanied by neuronal damage and reduced inhibitory influence over all processes. Based on the analysis of literature data, we studied the mech

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9

Kravchenko, L. V., M. A. Levkovich, S. B. Berezhanskaya, et al. "Clinical and diagnostic significance of determining the cytokine status in infants with chronic cytomegalovirus infection against the background of hypoxic-ischemic CNS damage." CHILDREN INFECTIONS 21, no. 3 (2022): 28–32. http://dx.doi.org/10.22627/2072-8107-2022-21-3-28-32.

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Objective: based on the production of cytokines, to identify the immunological features of the chronic course of cytomegalovirus infection in children of the first year of life against the background of hypoxic-ischemic CNS damage.Research methods:108 newborns with cytomegalovirus infection occurring against the background of perinatal hypoxic-ischemic lesions of the central unequal system were examined. All observed patients immediately after the diagnosis of cytomegalovirus infection underwent an immunological examination, including the determination of the levels of interferon-alpha (IFN-α)

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Mankovskyi, Dmytro S. "Hypoxic-ischemic brain injuries in cardiosurgical patients (rationale of causal connections)." BULLETIN OF MEDICAL AND BIOLOGICAL RESEARCH 4, no. 1 (2022): 64–69. http://dx.doi.org/10.11603/bmbr.2706-6290.2022.1.12972.

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Summary. The presented article substantiates the materials on causation in the most common variants of hypoxic-ischemic brain lesions in cardiac surgery patients. The study showed that the functional changes assumed by the patient's brain (under the conditions of heart surgery using the resources of artificial circulation), reflects the state of the structural patterns of the whole organism. The aim of the study – to analyze the clinical and anamnestic materials on pathogenetic prototypes of hypoxic-ischemic lesions that occur in patients as a result of cardiac surgery. Materials and Methods.

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11

Liu, Jia, Yakun Gu, Mengyuan Guo, and Xunming Ji. "Neuroprotective effects and mechanisms of ischemic/hypoxic preconditioning on neurological diseases." CNS Neuroscience & Therapeutics 27, no. 8 (2021): 869–82. http://dx.doi.org/10.1111/cns.13642.

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Mamaychuk, Irina, and Julia Milanich. "Features of mothers’ emotional experience during the hospitalization of newborns in connection with hypoxic affection of the central nervous system." Vestnik of Saint Petersburg University. Psychology 11, no. 1 (2021): 89–102. http://dx.doi.org/10.21638/spbu16.2021.106.

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Mothers of newborns with central nervous system pathology tend to experience more severe psychological distress and difficulty in forming a favourable relationship to their child than mothers of healthy infants. To provide psychological assistance, there is a need to better understand the features of the experience that parents find stressful and which ones are positive, in order to cope with stress. The objective of the research was to study mothers’ emotional experience during the hospitalization of newborns with hypoxic affection of the central nervous system (CNS). The research included 40

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Morozov, A. M., T. V. Sorokovikova, K. A. Aleksanyan, K. G. Salmanova, and A. N. Pichugova. "Analysis of risk factors and hypoxic-ischemic damage consequences to central nervous system in newborns." Medical alphabet, no. 33 (January 22, 2024): 24–27. http://dx.doi.org/10.33667/2078-5631-2023-33-24-27.

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Perinatal damage to the central nervous system (CNS) is currently a pressing issue within the structure of neonatal pathology, leading to the development of various neurological complications and causing disability and death.The purpose. Identifying risk factors contributing to perinatal third-degree hypoxic-ischemic damage of the CNS in newborns and to examine the data of clinical, laboratory and instrumental studies.Results. In the course of this study, it was revealed that the leading syndromes at the birth of the majority of infants from the main group were the suppression syndrome and the

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14

Kasian, Svitlana, Andrij Loboda, Oleksandr Smiyan, et al. "The lead content in biological media term infants with hypoxic-ischemic CNS." Bangladesh Journal of Medical Science 20, no. 2 (2021): 330–33. http://dx.doi.org/10.3329/bjms.v20i2.51543.

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Introduction: The frequency of births of infants with perinatal pathology has increased inrecent years. The aim of this study is to determination of lead content in the biomedias ofnewborns with hypoxic-ischemic damage of the central nervous system (CNS). Materials andMethods: We studied influence of the lead content in children, which were born with hypoxicischemiclesion CNS (HIL CNS). Determination of this microelement was carried out in theblood serum, erythrocytes and urine of 30 newborn infants which were suffered from asphyxiaafter birth. The comparison group consisted of 30 health

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Gurbanova Jamila, Ali-zade Samaya, Asadova Tarana, Alieva Gulshan, Dadasheva Dinara, and Alieva Khanim. "Clinical and laboratory study of premature infants with hypoxic-ischemic encephalopathy." International Journal of Science and Research Archive 9, no. 2 (2023): 920–25. http://dx.doi.org/10.30574/ijsra.2023.9.2.0674.

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We conducted a comprehensive clinical and laboratory study of 102 preterm infants with hypoxic-ischemic encephalopathy (HIE) of varying gestational ages. All preterm infants were born to mothers with a complicated obstetric history. Clinical manifestation of CNS hypoxic-ischemic injury was observed in 100% of this cohort. Intracranial hemorrhages (ICH) of grades I-IV were registered in 38 (37.2%) cases, while periventricular leukomalacia (PVL) was present in 5 (4.9%) cases. Intrauterine growth restriction (IUGR) was observed in 36 (35.3%) cases, and respiratory distress syndrome (RDS) in 65 (6

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16

Huang, Sammen, Haitao Wang, Ekaterina Turlova та ін. "GSK-3β inhibitor TDZD-8 reduces neonatal hypoxic-ischemic brain injury in mice". CNS Neuroscience & Therapeutics 23, № 5 (2017): 405–15. http://dx.doi.org/10.1111/cns.12683.

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Baranouskaja, E. I., S. V. Zhavoronok, G. A. Shishko, and A. Voronetsky. "THE HERPES VIRUS INFECTION INFLUENCE OF THE MOTHER TO CONDITION OF THE NEWBORN." Health and Ecology Issues 1, no. 2 (2004): 55–60. http://dx.doi.org/10.51523/2708-6011.2004-1-2-9.

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Purpose of the objective is to study the influence of the Herpes Virus Infection on the course and the outcome of the pregnancy, pathology of the fetus and newborn. Methods: immunoassay (ELISA), immunofluorescence (MIF), polymerase chain reaction (PCR), statistical. All together 322 pregnant women from the perinatal risk group, whose pregnancy favorable resulted examined. The received results: The Chronically latent Herpes Virus Infection of the mother complicates the pregnancy, conduces to CNS affection in the form of the ischemic-hypoxic encephalopathy of the fetus and newborn. 61% pregnant

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Chichanovskaya, L. V., T. V. Sorokovikova, T. V. Tkacheva, A. M. Morozov, V. A. Morozova, and D. R. Ivanova. "Epidemiology of hypoxic-ischemic lesions of the central nervous system in newborn children." Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of Neurology, Psychiatry and Neurosurgery), no. 12 (November 30, 2024): 1524–33. https://doi.org/10.33920/med-01-2412-13.

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Hypoxic-ischemic lesions are conditions that develop in premature and preterm infants, resulting in central nervous system disorders, the main cause of which is perinatal asphyxia caused by hypoxia and ischemia. A more complete picture in terms of epidemiology of CNS lesions in perinatal age is given by the introduction of a unified (end-to-end) registry of patients and the practice of standardizing approaches to the classification (systematization) of these lesions. In this regard, bringing the routinely practiced approaches to a common denominator (classifications of both RASPM and Sarnat an

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Mishra, Deepak, Nisha Keshary Bhatta, Arabindra Yadav, Lokraj Shah, Shikhar Pradhan, and Prakash Kumar Soni. "pH Prodigy: Predicting early Neonatal Destiny in Perinatal Asphyxia through cord Blood’s Crystal ball." Journal of Nepal Paediatric Society 44, no. 1 (2024): 74–82. https://doi.org/10.60086/jnps1186.

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Introduction: Perinatal asphyxia, a condition affecting blood flow or gas exchange during birth, is a major contributor to neonatal morbidity and mortality. It adversely impacts various body systems, including renal, CNS, cardiac, and pulmonary functions. Common assessment methods, like Apgar scores, have limitations in subjectivity and sensitivity. Advanced technologies like aEEG and MRI, while more predictive, may lack universal accessibility. Studies exploring cord blood gas analysis as a link to short-term outcomes show promise in addressing perinatal asphyxia-related morbidity and mortali

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Sekhar, Manchala Chandra. "Correlation of Hypoxic Ischemic Encephalopathy Stages with Clinical Variables." Asian Journal of Clinical Pediatrics and Neonatology 8, no. 3 (2020): 1–6. http://dx.doi.org/10.47009/ajcpn.2020.8.3.1.

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Background: Injury to the CNS related with perinatal asphyxia is referred to as Hypoxic-Ischemic Encephalopathy which is the utmost severe neurological condition that arises in perinatal periods. The aim is to assess clinical variables with hypoxic-ischemic encephalopathy stages. Subjects and Methods: A clinical study of 42 new borns asphyxiated were assessed clinically of these asphyxiated neonates was carried out using Sarnath and Sarnath Staging of HIE. The association between asphyxia at birth and HIE has been examined. Results: In the present study, maternal history, gestational age, and

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Stoica, Simona Isabelle, Coralia Bleotu, Vlad Ciobanu, et al. "Considerations about Hypoxic Changes in Neuraxis Tissue Injuries and Recovery." Biomedicines 10, no. 2 (2022): 481. http://dx.doi.org/10.3390/biomedicines10020481.

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Hypoxia represents the temporary or longer-term decrease or deprivation of oxygen in organs, tissues, and cells after oxygen supply drops or its excessive consumption. Hypoxia can be (para)-physiological—adaptive—or pathological. Thereby, the mechanisms of hypoxia have many implications, such as in adaptive processes of normal cells, but to the survival of neoplastic ones, too. Ischemia differs from hypoxia as it means a transient or permanent interruption or reduction of the blood supply in a given region or tissue and consequently a poor provision with oxygen and energetic substratum-inflamm

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Ibragimova, Nadiya Sabirovna, Dinora Norkobil kizi Diamatova, and Nodir Ural ugli Rajabov. "INFLUENCE OF GESTATION DATE ON THE SEVERITY OF HYPOXIC-ISCHEMIC ENCEPHALOPATHY IN NEWBORN." Research Focus 1, no. 4 (2023): 48–51. https://doi.org/10.5281/zenodo.7497862.

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Identification of the leading cause of CNS dysfunction in a newborn, even with a thorough examination, is often a difficult task. The nature and depth of the pathological process in the brain and spinal cord remain unclear, neurological disorders are dynamic, and an accurate prediction of further development is difficult.<strong> </strong>In this regard, the use of the terms "encephalopathy" is justified, to refer to "transient and unclassified pathological conditions of the central nervous system." Despite the progress of perinatal medicine, hypoxic-ischemic encephalopathy

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Wei, Yanhong, Junsong Gong, Zhenhua Xu, et al. "Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A." Proceedings of the National Academy of Sciences 112, no. 50 (2015): E6927—E6936. http://dx.doi.org/10.1073/pnas.1512683112.

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Delayed revascularization of ischemic neural tissue is a major impediment to preservation of function in central nervous system (CNS) diseases including stroke and ischemic retinopathies. Therapeutic strategies allowing rapid revascularization are greatly needed to reduce ischemia-induced cellular damage and suppress harmful pathologic neovascularization. However, key mechanisms governing vascular recovery in ischemic CNS, including regulatory molecules governing the transition from tissue injury to tissue repair, are largely unknown. NF-E2-related factor 2 (Nrf2) is a major stress-response tr

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Вороньжев, Ігор Олександрович. "Radiological features of pneumonia in children with hypoxic-ischemic and traumatic CNS injuries." ScienceRise 3, no. 4(8) (2015): 74. http://dx.doi.org/10.15587/2313-8416.2015.39301.

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Miheeva, I. G., P. A. Lopanchuk, Y. A. Kuznetsova, T. G. Vereschagina, A. Y. Kruglyakov, and O. V. Tyunyaeva. "MICROVASCULAR ABNORMALITIES IN NEWBORNS OF DIFFERENT GESTATIONAL AGE WITH HYPOXIC-ISCHEMIC CNS LESION." PEDIATRIA Journal named after G.N.SPERANSKY 96, no. 1 (2017): 10–15. http://dx.doi.org/10.24110/0031-403x-2017-96-1-10-15.

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Blinov, D. V., and A. A. Terent’ev. "Protein markers of hypoxic-ischemic lesions of the CNS in the perinatal period." Neurochemical Journal 7, no. 1 (2013): 16–22. http://dx.doi.org/10.1134/s1819712413010029.

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Mazur, Marcus, Robert H. Miller, and Shenandoah Robinson. "Postnatal erythropoietin treatment mitigates neural cell loss after systemic prenatal hypoxic-ischemic injury." Journal of Neurosurgery: Pediatrics 6, no. 3 (2010): 206–21. http://dx.doi.org/10.3171/2010.5.peds1032.

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Object Brain injury from preterm birth predisposes children to cerebral palsy, epilepsy, cognitive delay, and behavioral abnormalities. The CNS injury often begins before the early birth, which hinders diagnosis and concurrent treatment. Safe, effective postnatal interventions are urgently needed to minimize these chronic neurological deficits. Erythropoietin (EPO) is a pleiotropic neuroprotective cytokine, but the biological basis of its efficacy in the damaged developing brain remains unclear. Coordinated expression of EPO ligand and receptor expression occurs during CNS development to promo

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Ledyaikina, Lyudmila Viktorovna, Larisa Alexandrovna Balykova, Svetlana Vasilyevna Garina, et al. "SOME ASPECTS OF THE PATHOGENESIS OF ISCHEMIC-HYPOXIC LESIONS OF THE CENTRAL NERVOUS SYSTEM IN NEWBORNS." Samara Journal of Science 4, no. 2 (2015): 112–15. http://dx.doi.org/10.17816/snv20152133.

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The problem of perinatal morbidity in case of insufficiently high fertility in Russia is one of the most relevant at the monent. The leading cause of perinatal morbidity and mortality continue to remain hypoxic-ischemic brain damage the fetus and newborn. Ischemic-hypoxic damage of the central nervous system (CNS) is the most dangerous and prognostic significance. They often fatal and takes a leading role in the future of children and maladjustment of severe disabling diseases. Introduction of innovative medical technologies in health care practice greatly enhances the study of the causes of m

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Gilani, Ahmed, Johan LK Van Hove, Janet A. Thomas, and Bette K. Kleinschmidt-DeMasters. "Distinguishing Encephaloclastic Lesions Resulting From Primary or Secondary Pyruvate Dehydrogenase Deficiency From Other Neonatal or Infantile Cavitary Brain Lesions." Pediatric and Developmental Pathology 23, no. 3 (2019): 189–96. http://dx.doi.org/10.1177/1093526619876448.

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The central nervous system (CNS) is a highly complex and energy-dependent organ that is subject to a wide variety of metabolic, hypoxic-ischemic, and infectious insults that result in cystic changes. Diagnosis of metabolic defects causing extensive cystic changes is particularly challenging for the pediatric pathologist, due to the rarity of these conditions. Pyruvate dehydrogenase (PDH) deficiency is one of the most common etiologies of congenital lactic acidosis, caused by mutations in subunits of the large mitochondrial matrix complex, and characterized by periventricular cysts, although fe

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Adams, Lauren E., Hunter G. Moss, Danielle W. Lowe, et al. "NAC and Vitamin D Restore CNS Glutathione in Endotoxin-Sensitized Neonatal Hypoxic-Ischemic Rats." Antioxidants 10, no. 3 (2021): 489. http://dx.doi.org/10.3390/antiox10030489.

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Therapeutic hypothermia does not improve outcomes in neonatal hypoxia ischemia (HI) complicated by perinatal infection, due to well-described, pre-existing oxidative stress and neuroinflammation that shorten the therapeutic window. For effective neuroprotection post-injury, we must first define and then target CNS metabolomic changes immediately after endotoxin-sensitized HI (LPS-HI). We hypothesized that LPS-HI would acutely deplete reduced glutathione (GSH), indicating overwhelming oxidative stress in spite of hypothermia treatment in neonatal rats. Post-natal day 7 rats were randomized to s

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Ataee, Zahra, and Bita Dadpour. "Hypoxic-ischemic encephalopathy in a young man due to tramadol overdose." Journal of Emergency Practice and Trauma 6, no. 2 (2019): 112–14. http://dx.doi.org/10.34172/jept.2019.21.

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Objective: Tramadol is a synthetic analgesic with two mechanisms. The opioid and non-opioid mechanisms are responsible for tramadol side effects. Non-opioid side effects of tramadol are due to the reuptake inhibitions of serotonin and norepinephrine. Some of the side effects include anaphylactoid reactions, CNS depression, hypoglycemia, hypotension, respiratory depression, seizures, and serotonin syndrome. Seizure may happen in therapeutic doses. If the frequency of tramadol seizures increases, ischemic brain injury and hypoxic-ischemic encephalopathy can be induced. Case Report: We report a y

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Kaminiów, Konrad, Sylwia Kozak, and Justyna Paprocka. "Neonatal Seizures Revisited." Children 8, no. 2 (2021): 155. http://dx.doi.org/10.3390/children8020155.

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Seizures are the most common neurological disorder in newborns and are most prevalent in the neonatal period. They are mostly caused by severe disorders of the central nervous system (CNS). However, they can also be a sign of the immaturity of the infant’s brain, which is characterized by the presence of specific factors that increase excitation and reduce inhibition. The most common disorders which result in acute brain damage and can manifest as seizures in neonates include hypoxic-ischemic encephalopathy (HIE), ischemic stroke, intracranial hemorrhage, infections of the CNS as well as elect

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Aleksandrov, A. G., and D. A. Petrenko. "Promising biomarkers of blood-brain barrier permeability impairment in rehabilitation of infants with perinatal hypoxic-ischemic central nervous system injury." Rehabilitology 2, no. 2 (2024): 207–15. http://dx.doi.org/10.17749/2949-5873/rehabil.2024.9.

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Background. Diagnostics, treatment and rehabilitation of newborns with injury of the central nervous system (CNS) tissues are one of the pressing problems of contemporary medical community. Early diagnostics of hypoxic-ischemic damage to CNS tissues is a key element in the strategy of supporting newborns with asphyxia. The search for sensitive and specific diagnostic tools will improve the prognosis of disease outcome and the effectiveness of rehabilitation.Objective: to identify promising serum biomarkers of brain tissue damage for screening and monitoring in neonates.Material and methods. Th

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Dolgova, N. S., S. D. Yavorskaya, L. P. Anan’ina, and E. V. Pozhenko. "OBSTETRICAL ASPECTS OF FORMATION OF HYPOXIC-ISCHEMIC CNS DISORDERS IN FULL-TERM LOW-WEIGHT NEWBORNS." Bulletin of Medical Science, no. 4(8) (2017): 64–67. http://dx.doi.org/10.31684/2541-8475.2017.4(8).64-67.

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Gluckman, Peter, Nicolin Klempt, Jian Guan, et al. "A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury." Biochemical and Biophysical Research Communications 182, no. 2 (1992): 593–99. http://dx.doi.org/10.1016/0006-291x(92)91774-k.

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Guse, Kirsten, Nina Hagemann, Lisa Thiele, et al. "CNS Antigen-Specific Neuroinflammation Attenuates Ischemic Stroke With Involvement of Polarized Myeloid Cells." Neurology - Neuroimmunology Neuroinflammation 9, no. 4 (2022): e1168. http://dx.doi.org/10.1212/nxi.0000000000001168.

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Background and ObjectivesExperimental studies indicate shared molecular pathomechanisms in cerebral hypoxia-ischemia and autoimmune neuroinflammation. This has led to clinical studies investigating the effects of immunomodulatory therapies approved in multiple sclerosis on inflammatory damage in stroke. So far, mutual and combined interactions of autoimmune, CNS antigen-specific inflammatory reactions and cerebral ischemia have not been investigated so far.MethodsActive MOG35-55 experimental autoimmune encephalomyelitis (EAE) was induced in male C57Bl/6J mice. During different phases of EAE, t

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Xu, Ming‐Yue, Yang‐Fan Wang, Peng‐Ju Wei, Yan‐Qin Gao, and Wen‐Ting Zhang. "Hypoxic preconditioning improves long‐term functional outcomes after neonatal hypoxia–ischemic injury by restoring white matter integrity and brain development." CNS Neuroscience & Therapeutics 25, no. 6 (2019): 734–47. http://dx.doi.org/10.1111/cns.13102.

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Li, Longxuan, Jennifer V. Welser та Richard Milner. "Absence of the αvβ3 Integrin Dictates the Time-Course of Angiogenesis in the Hypoxic Central Nervous System: Accelerated Endothelial Proliferation Correlates with Compensatory Increases in α5β1 Integrin Expression". Journal of Cerebral Blood Flow & Metabolism 30, № 5 (2010): 1031–43. http://dx.doi.org/10.1038/jcbfm.2009.276.

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Cerebral angiogenesis is an important adaptive response to hypoxia. As the αvβ3 integrin is induced on angiogenic vessels in the ischemic central nervous system (CNS), and the suggested angiogenic role for this integrin in other systems, it is important to determine whether the αvβ3 integrin is an important mediator of cerebral angiogenesis. αvβ3 integrin expression was examined in a model of cerebral hypoxia, in which mice were subject to hypoxia (8% O2) for 0, 4, 7, or 14 days. Immunofluorescence and western blot analysis revealed that in the hypoxic CNS, αvβ3 integrin was strongly induced o

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Smirnov, Ivan E., A. A. Stepanov, L. D. Shakina, I. A. Belyaeva, E. P. Bombardirova, and A. G. Kucherenko. "Neurologic manifestations of cerebral ischemia in infants at 1 year of age." Russian Pediatric Journal 19, no. 5 (2019): 274–82. http://dx.doi.org/10.18821/1560-9561-2016-19-5-274-282.

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Hypoxic-ischemic brain damage of the newborn infant to date is the one of the major problems in neonatology. The comprehensive clinical, laboratory and neurological examination of newborns of different gestational ages with perinatal CNS disorder was executed with the use of informative diagnostic technologies. Structural and functional disorders caused by cerebral ischemia, were established to be accompanied by significant changes in brain activity, the severity of which increases with decreasing gestational age of newborns. Certain concentrations of plasma factors of hemostasis in newborns w

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Shulyatnikova, T. V., and L. M. Tumanska. "Pathomorphological parameters of sepsis-associated encephalopathy in deceased septic patients without purulent lesions to the brain." Modern medical technology 16, no. 2 (2024): 77–85. http://dx.doi.org/10.14739/mmt.2024.2.305087.

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Sepsis-associated encephalopathy (SAE) clinically manifests by delirium and decreased consciousness less than 15 points on Glasgow Coma Scale. SAE pathophysiology includes neuroinflammation, ischemic-hypoxic and dysmetabolic mechanisms. Despite the high frequency and the important role in thanatogenesis, pathomorphological criteria of SAE remain to be defined. The aim of the study was to specify the key pathomorphological parameters of sepsis-associated encephalopathy in deceased septic patients without purulent lesions to the brain by defining the changes of neurogliovascular unit and the lev

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Kioka, Naomi, Koichi Minami, Akira Tamura, and Norishige Yoshikawa. "Chemokine Expression in Human Astrocytes in Response to Shiga Toxin 2." International Journal of Inflammation 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/135803.

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Infection with Shiga toxin- (Stx-) producingEscherichia colican lead to hemolytic uremic syndrome (HUS). Approximately, 30% of patients with HUS suffer from complications in the central nervous system (CNS), which is an important determinant of mortality in such patients. Autopsy shows mostly edema and hypoxic-ischemic changes in the CNS, often with microhemorrhages. It has been suggested that Stx-induced damage to human brain endothelial cells, which are essential constituents of the blood-brain barrier, plays a crucial role in the development of the CNS complications. However, it is unclear

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Halactionova, I. V., O. I. Iziumets, N. D. Korolova, K. V. Zhuk, and V. Y. Angelska. "Evaluation of the effectiveness of early intervention methods in newborns who have suffered hypoxic-ischemic CNS damage." Biomedical and Biosocial Anthropology, no. 40 (November 27, 2021): 60–65. http://dx.doi.org/10.31393/bba40-2020-10.

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Timely diagnosis of cerebral disorders both in the prenatal period and in the early neonatal period, as well as early rehabilitation treatment is the basis for the prevention of childhood disability. To this end, the so-called Early Intervention System is being introduced in Ukraine. The effectiveness of early intervention techniques directly depends on timely diagnosis and correctly chosen intervention tactics. Given the high neuroplasticity of the developing brain, it is advisable to start the elements of neurodevelopmental therapy from infancy. The aim of the work is to evaluate the effecti

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Safina, A. I., E. V. Volyanyuk, M. V. Potapova, and T. S. Fisheleva. "STATE OF HEALTH OF PREMATURE CHILDREN: ACCORDING TO THE DATA OF KAZAN CITY CATAMNESIS CENTER." Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 63, no. 5 (2018): 192–96. http://dx.doi.org/10.21508/1027-4065-2018-63-5-192-196.

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The article presents the analysis of the health status of children born prematurely during the first year of their life. There is the comparison of morbidity rates for five years of the operation of the catamnesis center of Kazan. Profoundly premature children demonstrated the highest level of morbidity with more frequent pathologies of the central nervous system, respiratory organs, eyes and anemia of premature children. In 2017 there was a decrease in the frequency and severity of respiratory diseases (bronchopulmonary dysplasia with chronic respiratory insufficiency 1.6 times), the nervous

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Kim, Brian H., Mariano Guardia Clausi, Michelle Frondelli, et al. "Age-Dependent Effects of ALK5 Inhibition and Mechanism of Neuroprotection in Neonatal Hypoxic-Ischemic Brain Injury." Developmental Neuroscience 39, no. 1-4 (2017): 338–51. http://dx.doi.org/10.1159/000477490.

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Neonatal encephalopathy due to hypoxic-ischemic (HI) brain injury triggers a wave of neuroinflammatory events attributed to causing the progressive degeneration and functional deficits seen weeks after the initial insult. In a recent set of studies, we evaluated the therapeutic efficacy of a small molecule antagonist for ALK5 (activin-like kinase 5 ), TGF-β receptor in a rat model of moderate perinatal HI and found significant improvements in neurologic outcomes. Here, we have extended those studies to evaluate the efficacy of delayed TGF-β receptor antagonism on postnatal day (P) 6 and P9 HI

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Ji, Gang, Ming Liu, Xiong-Fei Zhao та ін. "NF-κB Signaling is Involved in the Effects of Intranasally Engrafted Human Neural Stem Cells on Neurofunctional Improvements in Neonatal Rat Hypoxic-Ischemic Encephalopathy". CNS Neuroscience & Therapeutics 21, № 12 (2015): 926–35. http://dx.doi.org/10.1111/cns.12441.

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Anusha, Manda, Avirendla Sony, Syeda Mohammadi Begum, Velupula Neelima, and Amatul Haseeb Maseera. "Non-Traumatic Coma in Children- A Review." Asian Journal of Pediatric Research 13, no. 2 (2023): 76–81. http://dx.doi.org/10.9734/ajpr/2023/v13i2266.

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Coma is defined as the unintentional failure of the patient to open their eyes spontaneously or in response to noise and inability to open for commands or localised painful stimuli with or without the ability to express comprehensible words or language response, whereas the Non traumatic coma is without any injury to the brain, and the Glasgow coma scale below 12. The Non traumatic coma causes due to the infections(tubercular meningitis, bacterial meningitis, encephalitis) and other metabolic conditions ,status epilepticus intracranial bleed, miscellaneous, hypoxic ischemic insults, Electrical

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Atakhanovna, Khodjaeva Svetlana, Pardayeva Uguloy Djamalovna, and Kayumova Shakhlo Shukhratovna. "Analysis Of Risk Factors For Hypoxic Damages Of Newborn`S Central Nervous System." INTERNATIONAL JOURNAL OF HEALTH SYSTEMS AND MEDICAL SCIENCES 3, no. 2 (2024): 21–25. http://dx.doi.org/10.51699/ijhsms.v3i2.3437.

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Currently, perinatal damage to the central nervous system of newborns occupies an important place in the structure of pathology of young children, which is associated with high prevalence, severity of clinical manifestations and the risk of disability formation. The purpose of our study was to determine the significance of risk factors for the development and to develop criteria for the severity of hypoxic-ischemic CNS damage in newborns. We examined 120 newborns with moderate to severe perinatal CNS damage. The examination consisted of the collection of maternal history, which included inform

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Reddy, Ravikanth. "Magnetic Resonance Imaging Evaluation of Perinatal Hypoxic Ischemic Encephalopathy: An Institutional Experience." Journal of Neurosciences in Rural Practice 13, no. 01 (2022): 087–94. http://dx.doi.org/10.1055/s-0041-1742157.

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Abstract Background Hypoxic–ischemic encephalopathy (HIE) is the most commonly diagnosed neurological abnormality affecting children leading to severe neurological deficits and a cause of neonatal mortality. HIE constitutes a diagnostic challenge in the prematurely born and full-term neonates. HIE causes severe neurological deficit in children and many a times goes unnoticed in early stages. The various patterns of central nervous system (CNS) involvement in HIE are dependent on factors, such as severity and duration of hypoxia, and brain maturity in preterm and full-term patients. Magnetic re

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Jenkins, Dorothea D., Hunter G. Moss, Truman R. Brown, et al. "NAC and Vitamin D Improve CNS and Plasma Oxidative Stress in Neonatal HIE and Are Associated with Favorable Long-Term Outcomes." Antioxidants 10, no. 9 (2021): 1344. http://dx.doi.org/10.3390/antiox10091344.

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N-acetylcysteine (NAC) and vitamin D provide effective neuroprotection in animal models of severe or inflammation-sensitized hypoxic ischemic encephalopathy (HIE). To translate these FDA-approved drugs to HIE neonates, we conducted an early phase, open-label trial of 10 days of NAC (25, 40 mg/kg q12h) + 1,25(OH)2D (calcitriol 0.05 mg/kg q12h, 0.03 mg/kg q24h), (NVD), for pharmacokinetic (PK) estimates during therapeutic hypothermia and normothermia. We paired PK samples with pharmacodynamic (PD) targets of plasma isoprostanoids, CNS glutathione (GSH) and total creatine (tCr) by serial MRS in b

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Pugolovkin, K. A., E. A. Efimova, E. A. Dombrovskaya, I. Yu Platonova, and A. A. Solov’ev. "Transcranial Doppler ultrasound is a diagnostic and predicting tool for movement disorders in children after hypoxic ischemic encephalopathy." Russian Journal of Woman and Child Health 4, no. 3 (2021): 254–59. http://dx.doi.org/10.32364/2618-8430-2021-4-3-254-259.

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Aim: to assess brain circulation in the regions supplied by the basilar artery (BA) in children with movement disorders and motor skill delay in the late rehabilitative period after hypoxic ischemic encephalopathy and its importance for the objectivity of clinical data and evaluation of rehabilitative effect. Patients and Methods: 28 children (mean age one year seven months) with movement disorders and motor skill delay (after hypoxic ischemic CNS lesion in the perinatal period) without lower extremity paraparesis or Willis circle abnormalities (by Doppler ultrasound) were examined. Doppler ul

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