Relevant bibliographies by topics / IA-2

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'IA-2'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "IA-2"

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Hu, Y. F., H. L. Zhang, T. Cai, S. Harashima, and A. L. Notkins. "The IA-2 interactome." Diabetologia 48, no. 12 (November 5, 2005): 2576–81. http://dx.doi.org/10.1007/s00125-005-0037-y.

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Notkins, Abner Louis, Michael S. Lan, and R. David G. Leslie. "IA-2 and IA-2β: the immune response in IDDM." Diabetes / Metabolism Reviews 14, no. 1 (March 1998): 85–93. http://dx.doi.org/10.1002/(sici)1099-0895(199803)14:1<85::aid-dmr205>3.0.co;2-i.

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Kubosaki, A., S. Nakamura, and A. L. Notkins. "Dense Core Vesicle Proteins IA-2 and IA-2 : Metabolic Alterations in Double Knockout Mice." Diabetes 54, Supplement 2 (November 23, 2005): S46—S51. http://dx.doi.org/10.2337/diabetes.54.suppl_2.s46.

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Landais, D., H. Matthes, C. Benoist, and D. Mathis. "A molecular basis for the Ia.2 and Ia.19 antigenic determinants." Proceedings of the National Academy of Sciences 82, no. 9 (May 1, 1985): 2930–34. http://dx.doi.org/10.1073/pnas.82.9.2930.

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Kawasaki, Eiji, Liping Yu, Roberto Gianani, Charles F. Verge, Sunanda Babu, Ezio Bonifacio, and George S. Eisenbarth. "Evaluation of Islet Cell Antigen (ICA) 512/IA-2 Autoantibody Radioassays Using Overlapping ICA512/IA-2 Constructs1." Journal of Clinical Endocrinology & Metabolism 82, no. 2 (February 1997): 375–80. http://dx.doi.org/10.1210/jcem.82.2.3723.

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Kawasaki, E. "Evaluation of Islet Cell Antigen (ICA) 512/IA-2 Autoantibody Radioassays Using Overlapping ICA512/IA-2 Constructs." Journal of Clinical Endocrinology & Metabolism 82, no. 2 (February 1, 1997): 375–80. http://dx.doi.org/10.1210/jc.82.2.375.

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Henquin, Jean-Claude, Myriam Nenquin, Andras Szollosi, Atsutaka Kubosaki, and Abner Louis Notkins. "Insulin secretion in islets from mice with a double knockout for the dense core vesicle proteins islet antigen-2 (IA-2) and IA-2β." Journal of Endocrinology 196, no. 3 (December 10, 2007): 573–81. http://dx.doi.org/10.1677/joe-07-0496.

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Islet antigen-2 (IA-2 or ICA 512) and IA-2β (or phogrin) are major autoantigens in type 1 diabetes. They are located in dense core secretory vesicles including insulin granules, but their role in β-cell function is unclear. Targeted disruption of either IA-2 or IA-2β, or both, impaired glucose tolerance, an effect attributed to diminution of insulin secretion. In this study, we therefore characterized the dynamic changes in cytosolic Ca2+([Ca2+]c) and insulin secretion in islets from IA-2/IA-2β double knockout (KO) mice. High glucose (15 mM) induced biphasic insulin secretion in IA-2/IA-2β KO islets, with a similar first phase and smaller second phase compared with controls. Since the insulin content of IA-2/IA-2β KO islets was ∼45% less than that of controls, fractional insulin secretion (relative to content) was thus increased during first phase and unaffected during second phase. This peculiar response occurred in spite of a slightly smaller rise in [Ca2+]c, could not be attributed to an alteration of glucose metabolism (NADPH fluorescence) and also was observed with tolbutamide. The dual control of insulin secretion via the KATP channel-dependent triggering pathway and KATP channel-independent amplifying pathway was unaltered in IA-2/IA-2β KO islets, and so were the potentiations by acetylcholine or cAMP (forskolin). Intriguingly, amino acids, in particular the cationic arginine and lysine, induced larger fractional insulin secretion in IA-2/IA-2β KO than control islets. In conclusion, IA-2 and IA-2β are dispensable for exocytosis of insulin granules, but are probably more important for cargo loading and/or stability of dense core vesicles.
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Courtois, Hélène M., and R. Brent Tully. "COSMICFLOWS-2: TYPE Ia SUPERNOVA CALIBRATION ANDH0." Astrophysical Journal 749, no. 2 (April 5, 2012): 174. http://dx.doi.org/10.1088/0004-637x/749/2/174.

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Piquer, Sandra, Lionel Valera, Vito Lampasona, Bénédicte Jardin-Watelet, Stéphanie Roche, Claude Granier, Francoise Roquet, et al. "Monoclonal antibody 76F distinguishes IA-2 from IA-2β and overlaps an autoantibody epitope." Journal of Autoimmunity 26, no. 3 (May 2006): 215–22. http://dx.doi.org/10.1016/j.jaut.2005.12.001.

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Kim, Soo Mi, Franziska Theilig, Yan Qin, Tao Cai, Diane Mizel, Robert Faulhaber-Walter, Hiroki Hirai, et al. "Dense-core vesicle proteins IA-2 and IA-2β affect renin synthesis and secretion through the β-adrenergic pathway." American Journal of Physiology-Renal Physiology 296, no. 2 (February 2009): F382—F389. http://dx.doi.org/10.1152/ajprenal.90543.2008.

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IA-2 and IA-2β, major autoantigens in type 1 diabetes, are transmembrane proteins in dense-core vesicles, and their expression influences the secretion of hormones and neurotransmitters. The present experiments were performed to examine whether IA-2 and IA-2β modulate the release of renin from dense-core vesicles of juxtaglomerular granular cells in the kidney. Plasma renin concentration (PRC; ng angiotensin I·ml−1·h−1) was significantly reduced in mice with null mutations in IA-2, IA-2β, or both IA-2 and IA-2β compared with wild-type mice (876 ± 113, 962 ± 130, and 596 ± 82 vs. 1,367 ± 93; P < 0.01, P < 0.02, and P < 0.001). Renin mRNA levels were reduced to 26.4 ± 5.1, 39 ± 5.4, and 35.3 ± 5.5% of wild-type in IA-2−/−, IA-2β−/−, and IA-2/IA-2β−/− mice. Plasma aldosterone levels were not significantly different among genotypes. The regulation of PRC by furosemide and salt intake, and of aldosterone by salt intake, was maintained in all genotypes. IA-2 and IA-2β expression did not colocalize with renin but showed overlapping immunoreactivity with tyrosine hydroxylase. While propranolol reduced PRC in wild-type mice, it had no effect on PRC in IA-2/ IA-2β−/− mice. Renal tyrosine hydroxylase mRNA and immunoreactivity were reduced in IA-2/IA-2β−/− mice as was the urinary excretion of catecholamines. We conclude that IA-2 and IA-2β are required to maintain normal levels of renin expression and renin release, most likely by permitting normal rates of catecholamine release from sympathetic nerve terminals.
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Dissertations / Theses on the topic "IA-2"

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Savola, K. (Kaisa). "Role of IA-2 antibodies in clinical and preclinical type 1 diabetes." Doctoral thesis, University of Oulu, 2000. http://urn.fi/urn:isbn:9514256778.

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Abstract Previous scientific data suggest that beta-cell destruction in type 1 diabetes is mediated by an autoimmune process. This work was aimed at expanding existing knowledge of humoral autoimmunity by analysing antibodies against the intracellular part of the IA-2 protein (IA-2A) in 1200 patients with the disease, 750 siblings and more than 370 non-diabetic controls. IA-2A were present at the time of diagnosis in the overwhelming majority of patients with type 1 diabetes, and were associated with human leucocyte antigen (HLA) DR4 and DQB1*0302, but not with gender. Humoral autoimmunity was more marked in patients diagnosed when younger than 20 years of age than in older ones, but no noticeable association was observed between IA-2A and age under the age of 20 years. IA-2A in combination with antibodies to GAD65 (GADA) identified a higher proportion of patients younger than 15 years of age at the time of diagnosis than did islet cell antibodies (ICA) alone. The levels of IA-2A and the proportions of antibody-positive patients decreased with increasing duration of type 1 diabetes, although more than half of the patients still tested positive for IA-2A after 10 years of clinical disease. IA-2A, GADA, insulin autoantibodies (IAA) and ICA were detected with individual fluctuations in 8-14% of the siblings of children with type 1 diabetes monitored from the time of diagnosis of the proband, and the fluctuations were modified by HLA-defined genetic susceptibility, age of the siblings, family size and total number of detectable autoantibodies. IA-2A positivity detected at the time of diagnosis of the proband increased the risk of future disease in the siblings. The positive predictive value increased with increasing IA-2A levels, although individual risk assessment appeared to be a complex matter. In conclusion, IA-2 appears to be an important autoantigen in type 1 diabetes, since IA-2A is associated with the HLA haplotype that most strongly predisposes subjects to the disease and have the highest positive predictive value for future disease out of the four autoantibodies used for risk assessment purposes.
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Johnson, Carolyn Cromien. "Cloning and characterization of IA-2 specific autoantibodies in Type 1 diabetes." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/cloning-and-characterization-of-ia2-specific-autoantibodies-in-type-1-diabetes(889f8c5c-334d-49ed-9b2c-1fc6459a2134).html.

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The presence of one or more autoantibodies to characterized autoantigens (GAD, IA-2, (pro) insulin, Znt8) is commonly used to diagnose or predict Type 1 diabetes. 94% of patients express antibodies to at least one of the major islet autoantigens at the point of diagnosis: of these 70% have autoantibodies to IA-2, and 94% of patients can be identified by screening for multiple autoantibodies. Autoantibodies to IA-2 are known to appear in early or pre-diabetes, suggesting that the appearance of B cell reactivity to this antigen is an early event in the progression to disease. Recent studies have shown that Rituximab, a CD20 antibody, which depletes B cells, is able to preserve β-cell function in newly diagnosed patients, suggesting that B cell depletion may be an effective method of preventing β-cell destruction. Autoantigen specific B cell depletion in the NOD mouse, using a monoclonal anti-insulin antibody, restores immune tolerance to insulin. Similar strategies aimed at the specific depletion of islet autoantigen-reactive B cells may be effective in preventing diabetes progression in man. Development of such strategies requires knowledge of the nature of epitopes recognized by the B cell. The purpose of this study was to characterize specific targets of autoimmunity in type 1 diabetes using human monoclonal antibody fragments, developed from B cell lines and antigen specific B cells, alongside B cells within the inflammation in the type 1 diabetic pancreas. Antibody binding of sites on the IA-2 antigen was evaluated using NMR. Finally, site directed mutagenesis was used to determine specific residues important for antibody binding within known epitope regions. This study demonstrates the feasibility of generating monoclonal antibody fragments from monoclonal B cell lines, single B cells and archival material. This study also clarifies key regions required for autoantibody recognition of the juxtamembrane domain of the IA-2 protein, and provides a basis for future analysis of antibody binding of this antigen using NMR.
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Nguyen, Thi Bang Tam. "Regulation der Genexpression des Diabetes-assoziierten Autoantigens IA-2 in INS-1 Betazellen." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966456009.

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Weber, Dionys A. "Aufklärung der Struktur und Charakterisierung des ternären Komplexes aus BMP-2, BMPR-IA und ActR-IIB." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982568614.

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Soares, Andrea Ferreira. "Avaliação da expressão da BMP -2/4 e BMPR-IA em Carcinoma Epidermóide Oral metastático e não metastático." reponame:Repositório Institucional da UFS, 2007. https://ri.ufs.br/handle/riufs/1115.

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A expressão das proteínas morfogenéticas ósseas (BMPs) está alterada em vários cânceres humanos. A BMP-2/4 e o BMPR-IA foram recentemente encontrados superexpressos em lesões malignas e pré-malignas de alto risco em epitélio oral. Este estudo analisou a expressão da BMP-2/4 e seu receptor BMPR-IA em 23 espécimes de Carcinoma Epidermóide Oral (CEO), utilizando a imuno-histoquímica. O grupo controle constou de 10 casos de Hiperplasia Fibro-epitelial da mucosa oral. O grupo experimental foi constituído por 16 casos de CEO não metastático e 7 casos de CEO metastático. Utilizou-se o parâmetro presença ou ausência de metástase nodal para avaliar o prognóstico da doença. Os resultados demonstraram imunorreatividade fraca para a BMP-2/4 e o BMPR-IA em todos os espécimes do grupo controle. No grupo experimental com metástase, a BMP-2/4 exibiu forte expressividade (71,4%), enquanto que o BMPR-IA mostrou fraca expressão (85,7%). No grupo experimental sem metástase, evidenciou-se forte expressão para a BMP-2/4 (62,5%) e para o BMPR-IA (100%). Encontrou-se significância estatística para a associação entre o prognóstico do CEO e a intensidade de marcação da BMP-2/4 (p=0,002). Para o BMPR-IA não houve significância estatística à sua associação com o prognóstico da doença (p>0,001), em função do tamanho da amostra. Portanto, os resultados sugerem que a fraca expressividade do BMPR-IA associada à forte expressão da BMP-2/4, no grupo experimental com metástase, tem relevância prognóstica, já que a perda de sensibilidade às BMPs, através da perda de expressão de seus receptores pode ser indicativo de desenvolvimento de metástase em CEO. _________________________________________________________________________________________ ABSTRACT: The expression of bone morphogenetic proteins (BMPs) is altered in a variety of human canceres. The BMP-2/4 and BMPR-IA were recently shown to be overexpressed in high-risk premalignant and malignant lesions of oral epithelium. The present study analysed the expression of BMP-2/4 and BMPR-IA in Oral Squamous Cell Carcinoma (OSCC) such as their implications in disease prognostic using munohistochemistry. Ten cases of Oral Fibroepithelial Hiperplasia were selected as a control group. The experimental group included 16 cases of OSCC without metastases and 7 cases of OSCC metastatic. The presence or absence of nodal metastases was used as parameter to evaluated the disease prognostic. The results demonstrated weak immunoreactivity for BMP-2/4 and BMPR-IA in every case of the control group. In the cases of OSCC with metastases an overexpression of BMP-2/4 (71,4%) was observed while the BMPR-IA showed weak expression (85,7%). In the cases of OSCC without metastases BMP-2/4 (62,5%) and BMPR-IA showed strong immunostaining standing out an overexpression of the receptor in all the specimens. Observed statistical significance for correlation between the oral cancer prognostic and the staining intensity of the BMP-2/4 (p=0,002). There wasn t statistical significance for association between the staining intensity of the BMPR-IA and the disease prognostic (p>0,001). In conclusion, this findings suggest that the overexpression of BMP-2/4 associated with the loss of expression of the BMPR-IA in OSCC metastatic has prognostic relevance, as the loss of sensitivity to BMPs can be an indicative of metastases development in OSCC.
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Steinbrenner, Holger. "Untersuchungen zur Regulation der Genexpression des diabetes- assoziierten Autoantigens IA-2 in primären Inseln und INS-1-Zellen." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966358759.

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Kikkas, Ingrid. "Development of immunoassays for diagnosis of type 1 diabetes." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114824.

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Le diabète de type 1 est une maladie auto-immune caractérisée par la destruction des cellules bêta des îlots de Langerhans du pancréas. Au cours de ce processus auto-immun, des auto-anticorps sont produits contre plusieurs antigènes des cellules bêta, par exemple l'insuline, l'acide glutamique décarboxylase (GAD65), la protéine tyrosine phosphatase (IA-2) et le transporteur de zinc (ZnT8). Au moins un auto-anticorps contre l'un de ces antigènes est présent dans> 95% des personnes atteintes de diabète de type 1 lors de la détection de l'hyperglycémie. Ces auto-anticorps peuvent servir de marqueurs précoces de diabète de type 1, car ils peuvent être présents des années avant l'apparition de la maladie, ce qui permet un diagnostic précoce avant les manifestations cliniques. Dans le cadre de cette thèse, nous avons développé, en partenariat avec une équipe de recherche clinique, une série de tests diagnostiques originaux, basée sur la détection précoce des différents auto-anticorps d’îlots de Langerhans à partir d'échantillons de sérum humain. Ces tests de diagnostic comprennent des tests bridging ELISA pour la détection d'auto-anticorps contre l'insuline, IA-2 et GAD65, qui sont rapides, facile à utiliser et n’utilisent pas de radioactivité. De plus, un test immunochromatographique sur bandelette pour la détection des auto-anticorps contre IA-2 a été développé. Le principal avantage des tests bandelettes est sa convivialité : les résultats peuvent être obtenus en 45 min en utilisant de très petits volumes de sérums et sans l'utilisation d’appareils spécialisés. Tous ces tests développés en interne ont été validés avec des échantillons de sérum de patients atteints de diabète de type 1 et de témoins sains et leurs performances ont été comparées avec celles de tests disponibles sur le marché. En outre, nous avons développé un test multiplex pour la détection simultanée de plusieurs auto-anticorps associés au diabète de type 1, ce qui permet de gagner du temps et d’augmenter la valeur diagnostic et prédictive du test par rapport à la détection d’un seul autoanticorps. Ce test multiplex a été validé pour la détection de deux autoanticorps (IA-2A et GADA) et comparé à nos tests ELISA de IA-2A et GADA
Type 1 diabetes is an autoimmune disease characterized by the destruction of pancreatic beta cells within the islets of Langerhans. In the course of this autoimmune process, autoantibodies are generated against several beta-cell antigens, e.g. insulin, glutamic acid decarboxylase (GAD65), tyrosine phosphatase-like protein (IA-2) and zinc transporter 8 (ZnT8). At least one autoantibody against one of these antigens is present in >95% of individuals with type 1 diabetes upon hyperglycemia detection. These autoantibodies can serve as early markers of type 1 diabetes, since they can be present years before disease onset, allowing for an early diagnosis before clinical manifestations. In the course of this thesis we have developed, in partnership with a clinical research team, a series of original diagnostic tests, based on the early detection of the different anti-Langerhans islet autoantibodies from human serum samples. These diagnostic tests include bridging ELISAs for the detection of autoantibodies to insulin, IA-2 and GAD65, which are rapid, non-radioactive and easy-to-use. Moreover, a lateral flow immunoassay (dipstick) for detection of autoantibodies to IA-2 was developed. The key advantage of lateral flow immunoassay is its user-friendly format: results can be obtained within 45 min using very small volumes of sera and without the use of any specialized apparatus. All these in-house assays were validated with diabetic and healthy human serum samples and the assay performances were compared to commercially available tests on the market. In addition, we have developed a multiplex assay for simultaneous detection of multiple diabetes-associated autoantibodies, which is time-effective and increases the diagnostic and predictive values of the assay, comparing to single autoantibody detection. This multiplex assay was validated for detection of two autoantibodies i.e. IA-2A and GADA and compared to in-house IA-2A and GADA bridging ELISAs
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Soares, Andrea Ferreira. "Avalia??o da express?o da BMP -2/4 e BMPR-IA em carcinoma epiderm?ide oral metast?tico e n?o metast?tico." Universidade Federal do Rio Grande do Norte, 2007. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17139.

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The expression of bone morphogenetic proteins (BMPs) is altered in a variety of human canceres. The BMP-2/4 and BMPR-IA were recently shown to be overexpressed in high-risk premalignant and malignant lesions of oral epithelium. The present study analysed the expression of BMP-2/4 and BMPR-IA in Oral Squamous Cell Carcinoma (OSCC) such as their implications in disease prognostic using munohistochemistry. Ten cases of Oral Fibroepithelial Hiperplasia were selected as a control group. The experimental group included 16 cases of OSCC without metastases and 7 cases of OSCC metastatic. The presence or absence of nodal metastases was used as parameter to evaluated the disease prognostic. The results demonstrated weak immunoreactivity for BMP-2/4 and BMPR-IA in every case of the control group. In the cases of OSCC with metastases an overexpression of BMP-2/4 (71,4%) was observed while the BMPR-IA showed weak expression (85,7%). In the cases of OSCC without metastases BMP-2/4 (62,5%) and BMPR-IA showed strong immunostaining standing out an overexpression of the receptor in all the specimens. Observed statistical significance for correlation between the oral cancer prognostic and the staining intensity of the BMP-2/4 (p=0,002). There wasn t statistical significance for association between the staining intensity of the BMPR-IA and the disease prognostic (p<0,001). In conclusion, this findings suggest that the overexpression of BMP-2/4 associated with the loss of expression of the BMPR-IA in OSCC metastatic has prognostic relevance, as the loss of sensitivity to BMPs can be an indicative of metastases development in OSCC
A express?o das prote?nas morfogen?ticas ?sseas (BMPs) est? alterada em v?rios c?nceres humanos. A BMP-2/4 e o BMPR-IA foram recentemente encontrados superexpressos em les?es malignas e pr?-malignas de alto risco em epit?lio oral. Este estudo analisou a express?o da BMP-2/4 e seu receptor BMPR-IA em 23 esp?cimes de Carcinoma Epiderm?ide Oral (CEO), utilizando a imuno-histoqu?mica. O grupo controle constou de 10 casos de Hiperplasia Fibro-epitelial da mucosa oral. O grupo experimental foi constitu?do por 16 casos de CEO n?o metast?tico e 7 casos de CEO metast?tico. Utilizou-se o par?metro presen?a ou aus?ncia de met?stase nodal para avaliar o progn?stico da doen?a. Os resultados demonstraram imunorreatividade fraca para a BMP-2/4 e o BMPR-IA em todos os esp?cimes do grupo controle. No grupo experimental com met?stase, a BMP-2/4 exibiu forte expressividade (71,4%), enquanto que o BMPR-IA mostrou fraca express?o (85,7%). No grupo experimental sem met?stase, evidenciou-se forte express?o para a BMP-2/4 (62,5%) e para o BMPR-IA (100%). Encontrou-se signific?ncia estat?stica para a associa??o entre o progn?stico do CEO e a intensidade de marca??o da BMP-2/4 (p=0,002). Para o BMPR-IA n?o houve signific?ncia estat?stica ? sua associa??o com o progn?stico da doen?a (p<0,001), em fun??o do tamanho da amostra. Portanto, os resultados sugerem que a fraca expressividade do BMPR-IA associada ? forte express?o da BMP-2/4, no grupo experimental com met?stase, tem relev?ncia progn?stica, j? que a perda de sensibilidade ?s BMPs, atrav?s da perda de express?o de seus receptores pode ser indicativo de desenvolvimento de met?stase em CEO
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Ara?jo, Cristina Ruan Ferreira de. "Estudo cl?nico-patol?gico do carcinoma epiderm?ide de l?ngua e imunoistoqu?mico das prote?nas BMP-2, BMPR-IA, BMPR-II e endoglina." Universidade Federal do Rio Grande do Norte, 2009. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17141.

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Bone morphogenetic proteins (BMPs) are cytokines involved in proliferation and angiogenesis of many kind of human cancer. The present study analyzed the immunohistochemical expression of BMP-2, BMPR-II, BMPR-IA and endoglin (CD105) and their relationship with the biological behavior and local angiogenesis in tongue oral squamous cells carcinoma (SCC). The sample consisted of 25 cases of tongue SCC without metastasis, 25 tongue SCC with metastasis and 25 cases of Inflamatory Fibrous Hyperplasia (IFH).The histological grade of malignancy proposed by Bryne (1998), adapted by Miranda (2002) was used to classify all tongue SCC cases. Score 0 was attributed to absent-weak immunoexpression and score 1 for strong immunostaning and pattern of distribution was focal or diffuse. Microvessel counts (MVC) was established for CD105. Most of the patients with tongue SCC was male. The principal age in tongue SCC without metastasis was over 65 years and in tongue SCC with metastasis was between 45-65 years. There were predominance of stage II in TNM and in the specimens with high-grade, independent of studied group. For BMP-2, 56% of tongue SCC without metastasis and 72% tongue SCC with metastasis exhibited score 1 while the IFH showed secore 0 in 72% of the cases, with statistical association (p=0,007). Considering the BMPR-II, 52% of tongue SCC without metastasis exhibited score 0; 56% tongue SCC with metastasis and 60% IFH showed score 1. The majority cases of BMPR-IA demonstrated score 1 and 100% of CD105 exhibited strong immunoexpression in tongue SCC. Regarding the pattern distribution, it was noted a tendency to diffuse pattern for the proteins in all groups. The means of MVC were similar in tongue SCC without metastasis (32,91) and in tongue SCC with metastasis (32,05), however existed statistical difference with IFH (p<0,001). There was statistical association of BMP-2 expression with BMPR-II (p=0,008), BMPR-IA (p=0,006) and CD105 (p=0,046). An association between TNM and BMP-2 immunoexpression and their receptors was not detected, nevertheless this association was found with MVC (p=0,047) whose averages were higher for the stages II (35,97) e IV (35,69). No association between histological grading and these proteins was observed. This study suggests that the superexpression of BMP-2 signaling pathways acts on cell proliferation in tongue SCC and can be implicated with more invasive potential. Additionaly, the CD105 is a potent biological marker of neovascularization in this neoplasm and their association with BMP-2 and BMPR-IA receptor, showed that this type of cancer in BMP-2 is presented as pro-angiogenic in the metastatic process
As BMPs (prote?nas morfogen?ticas ?sseas) s?o citocinas relacionadas com a prolifera??o e angiog?nese em diversos tipos de c?ncer humano. Com este trabalho foi analisada a express?o imunoistoqu?mica das prote?nas BMP-2, BMPR-IA, BMPR-II e endoglina (CD105), correlacionando-a com o comportamento biol?gico e a angiog?nese local nos carcinomas epiderm?ides de l?ngua (CEL). A amostra foi composta de 25 casos de CEL sem met?stase (CELSM), 25 CEL com met?stase (CELCM) graduados segundo Bryne (1998) e adaptado por Miranda (2002), al?m de 25 casos de hiperplasia fibrosa inflamat?ria (HFI), utilizado como grupo controle. Foi utilizado escore 0 para marca??o ausente-fraca e 1 para forte; tipo de distribui??o focal ou difuso. Adicionalmente, para o CD105 foi realizada a contagem microvascular (MVC). A maior parte dos pacientes com CEL foi do sexo masculino, no grupo CELSM a faixa et?ria foi maior que 65 anos e o CELCM se encontrou entre 45-65 anos; houve predom?nio do est?gio II do TNM, assim como de esp?cimes de alto grau, independente do grupo estudado. Para BMP-2, 56% dos CELSM e 72% dos CELCM exibiram escore 1, enquanto a HFI exibiu 72% de escore 0, apresentando associa??o estat?stica (p=0,007). Para BMPR-II 52% dos CELSM exibiram escore 0; 56% CELCM e 60% da HFI escore 1 e no BMPR-IA ocorreu uma predomin?ncia de escore 1 e para o CD105 100% de marca??o forte nos CEL. Quanto ao tipo de distribui??o notou-se tend?ncia de distribui??o difusa de todas as prote?nas, em todos os grupos. Observaram-se, para MVC, m?dias muito semelhantes entre os CELSM (32,91) e os CELCM (32,05) exibindo, contudo, diferen?a estat?stica com as HFI (p<0,001).Observa-se uma associa??o estat?stica da BMP-2 com a BMPR-II (P=0,008), BMPR-IA (p=0,006) e o CD105 (0,046). N?o se observou associa??o entre o TNM e a imunoexpress?o da BMP-2 e seus receptores, por?m foi encontrada com a MVC (p=0,047), cujas maiores m?dias foram para os est?gios II (35,97) e IV (35,69), tal como n?o ocorreu associa??o entre a grada??o histol?gica e as prote?nas. Conclui-se que a superexpress?o da via de sinaliza??o da BMP-2 atua na prolifera??o celular, contribuindo para maior invasividade do CEL. O CD105 ? um potente marcador de neovasculariza??o deste neoplasma e sua associa??o com a BMP-2 e o receptor BMPR-IA, mostra que neste tipo de neoplasia a BMP-2 se apresenta como pr?-angiog?nico no processo metast?tico
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Schubert, Sandra. "The Role of [beta]2-Syntrophin Phosphorylation in Secretory Granule Exocytosis." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2006. http://nbn-resolving.de/urn:nbn:de:swb:14-1146851994562-42414.

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The trafficking of insulin secretory granules(SGs) of pancreatic b-cells is a tightly controlled complex network. Increasing evidence indicates that the cortical actin cytoskeleton modulates the mobility and exocytosis of SGs,yet the mechanisms anchoring SGs to the cytoskeleton is not completely understood.It has been shown by Ort et al.(2000,2001) that the cytoplasmic tail of an intrinsic membrane protein of the SGs named ICA512/IA-2 binds the PDZ domain of b2-syntrophin,which in turn binds to the F-actin-binding protein utrophin. These data also indicate that stimulation of SG exocytosis affects the phosphorylation of b2-syntrophin,hence altering its binding to ICA512.Therefore a model was proposed whereby SGs are anchored to the actin cytoskeleton through the ICA512/b2-syntrophin complex, whose dynamics are regulated by phosphorylation.To test this model GFP-b2-syntrophin stable INS-1 cell clones were generated.GFP-b2-syntrophin expression and localization pattern were similar to those of the endogenous protein. Electron microscopy showed that in GFP-b2-syntrophin INS-1 cells the number of SGs with a pear-like shape was increased relative to control cells. Insulin content and stimulated secretion were increased in three GFP-â2-syntrophin INS-1 cell clones,compared to non-transfected INS-1 cells and INS-1 cells expressing GFP. These increments correlated with the different expression levels of GFP-b2-syntrophin in the three GFP-b2-syntrophin INS-1 cell clones. These findings support the hypothesis that b2-syntrophin regulates the trafficking and exocytosis of SGs by modulating their tethering to the actin cytoskeleton.In order to confirm the proposed model, the phosphorylation of b2-syntrophin was investigated in more detail. Similar to endogenous b2-syntrophin,GFP-b2-syntrophin underwent Ca2+-dependent and okadaic acid-sensitive dephosphorylation upon stimulation of insulin secretion. Stimulation-dependent dephosphorylation was confirmed by immunoprecipitation of 32P-labeled GFP-b2-syntrophin.Mass spectrometry of immunoprecipitated GFP-b2-syntrophin allowed the identification of four serine-phosphorylation sites (S75,S90,S213,S373) that could affect the binding to ICA512.Mutants,in which all four phosphoserines, were replaced by either asp or ala to mimic(S/D) or prevent(S/A) phosphorylation were expressed in INS-1 cells. All S/D mutants retained a cortical localization,but by immunoblotting the pattern of the S75D allele differed from wild type and all other S/D alleles.Conversely, all S/A alleles were diffused cytosolically, except S213A,which was still restricted to the cortex. Finally, pull down assays showed increased binding of ICA512 to the S75A and S90D alleles compared to wild type b2-syntrophin,while the opposite was observed with the S75D and S90A mutants.Additionally,both the S75 and the S213 allele conform a consensus for phosphorylation by Cdk5,which is known to modulate insulin secretion. The phosphorylation of GFP-b2-syntrophin and particularly the S75 allele by Cdk5 was exhibited with pharmacological inhibitors,by in vitro phosphorylation and by RNAi. Taken together, these findings are consistent with the model by which phosphorylation of b2-syntrophin modulates the tethering of SGs to the cytoskeleton, and thereby their mobility and exocytosis. Specifically, the data of this thesis suggest that Cdk5-dependent phosphorylation of the S75 site of GFP-b2-syntrophin facilitates insulin secretion by reducing the interaction of b2-syntrophin with ICA512,thereby decreasing the actin cytoskeleton constrain on SG mobility. This process could occur in combination with the phosphatase-dependent dephosphorylation of b2-syntrophin at phosphosites other than S75
Der Transport Insulin-gefüllter sekretorische Granula(SG) ist ein streng kontrollierter komplexer Prozess.Es gibt vermehrt Beweise,dass das kortikale Actinzytoskelett die Ausschüttung der SGs beeinflusst.Bisher ist der Mechanismus der Verankerung von SGs am Zytoskelett noch nicht vollständig aufgeklärt.Ort et al.(2000,2001) haben gezeigt,daß der zytosoplasmatische Teil des trans-membranen SG-Proteins ICA512 mit der PDZ-Domäne von b2-Syntrophin interagiert.Dieses Protein bindet das F-Actin-Bindeprotein Utrophin.Die Ergebnisse zeigen außerdem,daß durch Stimulation der SG-Exozytose der Phosphorilierungsstatus von b2-Syntrophin beeinflusst wird,woraus ein verändertes Bindungsvermögen zu ICA512 resultiert.Es wurde ein Funktionsmodel vorgestellt,in dem sich SGs durch die Interaktion des ICA512/b2-Syntrophin Komplexes an das Actinzytoskelett binden.Dabei wird die Bindedynamik durch Phosphorilierung reguliert.Um dieses Model zu etablieren,wurden stabile GFP-b2-Syntrophin produzierende INS-1-Zellklone erzeugt.Die zelluläre Lokalisation und das Expressionsmuster von GFP-b2-Syntrophin stimmen mit dem des endogenen Proteins überein.Elektronenmikroskopie zeigte eine größe Anzahl oval-verformter SGs in GFP-b2-Syntrophin INS-1-Zellen im Vergleich zu Kontrollzellen.Verglichen mit nicht-transfizierten INS-1 Zellen waren in drei GFP-b2-Syntrophin INS-1-Zellklonen der Insulingehalt der Zellen und die stimulierte Insulinsekretion erhöht.Die Werte korrelierten mit den unterschiedlichen GFP-b2-Syntrophin Expressionsmengen der Klone.Diese Ergebnisse untermauern die Hypothese,daß b2-Syntrophin den Transport und die Sekretion der SGs durch Modulation ihres Bindevermögens an Actin reguliert.Um das postulierte Model genauer zu prüfen,wurde die Phosphorilierung von b2-Syntrophin detaillierter untersucht.Das GFP-Protein wurde,ähnlich dem endogenen b2-Syntrophin,durch Stimulation der Insulinausschüttung dephosphoriliert.Diese Dephosphorilierung ist Ca2+-abhängig und Okadeinsäuresensitiv.Die stimulationsabhängige Dephosphorilierung wurde durch Immunoprezipitation von 32P-markiertem GFP-b2-Syntrophin bestätigt.Massenspektrometrie des präzipitierten Proteins ermöglichte die Identifikation von vier Serin-Phosphorilierungsstellen(S75,S90,S213,S373),welche die Bindung zu ICA512 beeinflussen könnten.Mutanten,in denen die vier Phosphoserine durch Asp beziehungsweise Ala ersetzt wurden,um entweder eine Phosphorilierung(S/D) oder Dephosphorilierung(S/A) nachzuahmen,wurden in INS-1-Zellen exprimiert.Alle S/D Mutanten blieben kortikal lokalisiert.Das Expressionsmuster des S75D Allels unterschied sich jedoch von denen des Wild-Typs(wt).Im Gegensatz dazu waren alle S/A Allele zytosolisch verteilt.Eine Ausnahme bildete S213A,das an der Zellkortex lokalisiert blieb.Im Vergleich zu wt b2-Syntrophin zeigten PullDown-Assays eine erhöhte Bindung von ICA512 zu den S75A und S90D Allelen.Das Gegenteil konnte für die S75D und S90A Mutanten nachgewiesen werden.S75,S90 und S213 sind in einer Konsensussequenz für Cdk5-Phosphorilierung enthalten.Diese Kinase kann die Insulinsekretion regulieren.Die Phosphorilierung von b2-Syntrophin,insbesondere des S75 Allels durch Cdk5 wurde durch pharmakologische Inhibitoren,in vitro-Phosphorilierung und RNAi demonstriert.Zusammenfassend stimmen diese Erkenntnisse mit dem Model überein,daß die Phosphorilierung von b2-Syntrophin die Vernetzung von SGs mit Actin und dadurch deren Mobilität und Exozytose moduliert.Im Speziellen postulieren die Ergebnisse dieser Arbeit eine Cdk5-abhängige Phosphorilierung der S75 Stelle des b2-Syntrophins.Durch eine verminderte Interaktion von b2-Syntrophin und ICA512 erleichtert diese Mutante vermutlich die Insulinsekretion,da der Einfluss des Actinzytoskeletts auf die Granulamobilität vermindert ist.Dieser Prozess ereignet sich möglicherweise in Kombination mit einer Dephosphorilierung des b2-Syntrophins.in Kombination mit einer Dephosphorilierung des b2-Syntrophins
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Books on the topic "IA-2"

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Side, Jeffrey, and Adam Fieled, eds. Mother Earth Parts 1 & 2 on mp3 in IA. 3rd ed. Conshohocken, Pa: Internet Archive, 2013.

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United States. Congress. House. Select Committee on Aging. Subcommittee on Retirement Income and Employment. Retirement income for women: Hearing before the Subcommittee on Retirement Income and Employment of the Select Committee on Aging, House of Representatives, One Hundred First Congress, second session, July 2, 1990, Cedar Rapids, IA. Washington: U.S. G.P.O., 1990.

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Gavanelli, Marco, Evelina Lamma, and Fabrizio Riguzzi, eds. AI*IA 2015 Advances in Artificial Intelligence. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-24309-2.

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Serra, Roberto, and Rita Cucchiara, eds. AI*IA 2009: Emergent Perspectives in Artificial Intelligence. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-10291-2.

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Natalia, Pravdina. Ia privlekaiu dengi-2. Neva (SPb.), 2006.

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Ia dralsia na IL-2. Eksmo (M.), 2005.

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Fedorchenko, V. I. Svita rossiiskikh imperatorov V 2 knigakhKniga 2 M-Ia. Izdatelskie proekty, 2005.

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I, Korolkova. Ia budu pianistom. Metod. posobie dlia obucheniia ch.2. Feniks (Rostov), 2009.

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Peixoto, Fabiano Hartmann. Relatório Técnico Conclusivo - Realidades da IA para o profissional do Direito - Sem 2. Fabiano Hartmann Peixoto, 2020. http://dx.doi.org/10.29327/522910.

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Ia byl dushoi durnogo obshchestva...Sob. Soch. v 10-i tomakh. tom 2. Amfora, SPb, 2011.

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Book chapters on the topic "IA-2"

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Awad, Ahmed, Riccardo Tommasini, Mahmoud Kamel, Emanuele Della Valle, and Sherif Sakr. "D $$^2$$ 2 IA: Stream Analytics on User-Defined Event Intervals." In Advanced Information Systems Engineering, 346–61. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-21290-2_22.

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Kindler, Peter. "Der europäische Deliktsgerichtsstand und die gewerblichen Schutzrechte." In Italienisches, europäisches und internationales Immaterialgüterrecht, 129–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-662-62179-0_7.

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ZusammenfassungDie internationale Durchsetzung von gewerblichen Schutzrechten in der EU hängt prozessual vor allem davon ab, ob für Klagen aus der Verletzung geistigen Eigentums ein Deliktsgerichtsstand nach Art. 7 Nr. 2 Brüssel Ia-VO eröffnet ist. Daran hat der Inhaber des Immaterialgüterrechts ein erhebliches Interesse, wird doch der deliktische Erfolgsort regelmäßig in seinem Sitzstaat liegen. Die Anerkennung und Vollstreckung des Urteils im Sitzstaat des Gegners ist meist gesichert (Art. 35 ff. Brüssel Ia-VO). Ein Prozess vor den Gerichten des Staats, in dem der mutmaßliche Verletzer ansässig ist (Art. 4 Brüssel Ia-VO), liegt daher nicht unbedingt im Interesse des Rechteinhabers – dies auch im Hinblick auf die Vermeidung des höheren Zeit- und Kostenaufwands, der mit Auslandsprozessen verbunden ist. Der nachfolgende Beitrag zeigt jüngste Tendenzen in der einschlägigen Rechtsprechung auf.
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Layh, G., S. Schmitt, and T. M. Buchanan. "Interaction of Neisseria gonorrhoeae and protein IA with HEp-2 cells." In Gonococci and Meningococci, 745–51. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-009-1383-7_117.

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Luzzi, Sabino, Mattia Del Maestro, and Renato Galzio. "Microneurosurgery for Paraclinoid Aneurysms in the Context of Flow Diverters." In Acta Neurochirurgica Supplement, 47–53. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63453-7_7.

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AbstractThe advent of flow diverter (FD) stents has apparently reduced the role of microneurosurgery for paraclinoid aneurysms despite sparse high-quality evidence about their long-term effects.The present study critically reviews the overall results of a microneurosurgical series of 57 paraclinoid aneurysms.Of these aneurysms, 47.4% were regular in size while 19.3 were giant. Barami type I was predominant. In 21 aneurysms a hemorrhagic onset occurred. Pterional approach with intradural anterior clinoidectomy was preferred by far. Clipping was possible in 91.2% of aneurysms and a high-flow bypass was the choice in five cases. An mRS of 0–2 was achieved in 77.3% of patients, typically <50 years old.Visual field appeared improved or unchanged in 36.3% and 63.6% of the symptomatic patients, respectively. In 76.1% of incidental aneurysms, campimetry was unaffected by surgery.A complete aneurysm exclusion was achieved in 93% of cases using a single procedure. No recurrences were documented on an average follow-up of 54.1 ± 34 months.Microneurosurgery is still a valuable, definitive, and durable option for Barami type Ia, Ib, or II paraclinoid aneurysm, especially in patients <50 years old and visually symptomatic. Conditions other than these are ideal candidates for FD stents.
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Zhou, P., L. J. Quackenbush, B. Albini, and M. B. Zaleski. "Macrophage IA Hybrid Molecule as Product of the Ir-Thy-1 Genes." In H-2 Antigens, 297–304. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4757-0764-9_29.

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Pierce, Susan K., Ellen K. Lakey, Emanuel Margoliash, Lori A. Smolenski, and Lisa A. Casten. "The Presentation of Processed, Ia Restricted, T Cell Antigenic Peptides on Antigen Presenting Cell Surfaces." In H-2 Antigens, 485–92. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4757-0764-9_48.

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Stuart, P. Michael, and Jerold G. Woodward. "Ia Gene Expression in Non-Bone Marrow Derived Cells During Graft Vs Host Disease in the Mouse." In H-2 Antigens, 559–69. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4757-0764-9_56.

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Morere, J. F., C. Boaziz, J. L. Breau, D. Goldlust, and L. Israël. "Continuous prolonged intra-arterial (IA) chemotherapy for extensive locally recurrent breast cancer." In Proceedings of the 3rd International Congress on Neo-Adjuvant Chemotherapy, 202–4. Paris: Springer Paris, 1991. http://dx.doi.org/10.1007/978-2-8178-0782-9_50.

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Baluyut, Arthur R., V. Udhyakumar, J. Morris, and Bondada Subbarao. "A Role for Ia Antigens in B Cell Activation: Studies with Normal B Cells and A B Cell Lymphoma." In H-2 Antigens, 501–15. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4757-0764-9_50.

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Junker, Abbo. "2. Kapitel. Brüssel Ia-Verordnung (EuGVVO)." In Internationales Zivilprozessrecht, 72–204. Verlag C.H.BECK oHG, 2018. http://dx.doi.org/10.17104/9783406730740-72.

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Conference papers on the topic "IA-2"

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Cantley, Lewis C. "Abstract IA-2: PI3‐Kinase and cancer metabolism." In Abstracts: First AACR International Conference on Frontiers in Basic Cancer Research--Oct 8–11, 2009; Boston MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/0008-5472.fbcr09-ia-2.

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Xiang, Jianping, Adnan Siddiqui, Sabareesh K. Natarajan, and Hui Meng. "Size Ratio of Intracranial Aneurysms Predicts Rupture-Prone Hemodynamics." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53712.

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Hemodynamics plays an important role in IA pathophysiology and rupture.1, 2 Since flow dynamics is largely determined by geometry,3 IA hemodynamics has been thought to be dependent on the aneurysm and/or parent vessel morphology.
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Taufique, Mohammed H., Alex Okpisz, Haseeb N. Ahmed, John R. Riley, Mohammad M. Hasan, and Gian Gerosa. "A 512-KB level-2 cache design in 45-nm for low power IA processor silverthorne." In 2008 IEEE Custom Integrated Circuits Conference - CICC 2008. IEEE, 2008. http://dx.doi.org/10.1109/cicc.2008.4672105.

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Reza, Anna T., and Steven B. Nicoll. "Dynamic Hydrostatic Pressurization Differentially Regulates Extracellular Matrix Elaboration by Bovine Inner and Outer Annulus Fibrosus Cells Seeded on 3-D Polymer Scaffolds." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176539.

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Current surgical treatments for intervertebral disc (IVD) degeneration result in decreased mobility of the spine [1]. A tissue engineering approach may provide an alternative that restores both IVD structure and function. The IVD is comprised of three distinct regions: the outer annulus fibrosus (OA), inner annulus fibrosus (IA), and the nucleus pulposus (NP). Each of the cell populations within these regions possess unique phenotypic properties that are greatly influenced by environmental factors, such as the surrounding 3-D extracellular matrix (ECM) and mechanical loading (i.e., hydrostatic pressurization) [2]. As such, both the 3-D scaffold and in vitro culture conditions may have marked effects on the development of tissue-engineered IVD constructs. Although the influence of mechanical loading on IVD cells and explants has been investigated, no prior studies have examined the impact of hydrostatic pressurization on OA and IA cells in 3-D culture. Therefore, the objective of this study was to determine the effects of dynamic hydrostatic pressurization on OA and IA cells seeded on 3-D fibrous poly(glycolic acid)-poly(L-lactic acid) (PGA-PLLA) scaffolds. We hypothesized that the application of hydrostatic pressure would promote increased production of type II collagen and chondroitin sulfate proteoglycan in both OA- and IA-seeded constructs.
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Nomura, S., H. Nagata, N. Sone, K. Oda, T. Kokawa, and K. Yasunaga. "ANALYSIS OF PLATELET ANTIGENS FOR ANTI-PLATELET ANTIBODIES IN ITP USING FLOW CYTOMETRY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644582.

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Idiopathic thrombocytopenic purpura (ITP) is a syndrome caused by circulating antibodies reactive with the platelet membrane. The antigenic specificity of these antibodies is unknown. We have characterized new monoclonal antibodies that react with a determinant specific to GP Ib and GP Ib- Ia complex, and used flow cytometry to investigate platelets in ITP for antigenic determinants to which autoantibodies are directed. Forty cases of ITP were analyzed in detail by the platelet suspension immunofluorescence test(PSIFT) of von dem Borne et al. The monoclonal antibodies used were 5 against GP Ib-Ia complex (NNKY1-32, NNKY2-5, NNKY2-6, NNKY2-11, NNKY2-18) and 2 against GP lb (NNKY5-4, NNKY5-5). The reactivity of monoclonal antibodies was inhibited by the presence of autoantibody on platelets in some ITP patients. Differences in inhibition were found not only between monoclonal antibodies but also between cases.These results suggest that some ITP patients have circulating antibodies to GP Ib or GP II b - Ia, and that heterogeneous antibodies are present on platelets. Moreover, the presence of these autoantibodies may aggravate or initiate a bleeding tendency.
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Feng, Cong, and Jie Zhang. "Short-Term Load Forecasting With Different Aggregation Strategies." In ASME 2018 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/detc2018-86084.

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Effective short-term load forecasting (STLF) plays an important role in demand-side management and power system operations. In this paper, STLF with three aggregation strategies are developed, which are information aggregation (IA), model aggregation (MA), and hierarchy aggregation (HA). The IA, MA, and HA strategies aggregate inputs, models, and forecasts, respectively, at different stages in the forecasting process. To verify the effectiveness of the three aggregation STLF, a set of 10 models based on 4 machine learning algorithms, i.e., artificial neural network, support vector machine, gradient boosting machine, and random forest, are developed in each aggregation group to predict 1-hour-ahead load. Case studies based on 2-year of university campus data with 13 individual buildings showed that: (a) STLF with three aggregation strategies improves forecasting accuracy, compared with benchmarks without aggregation; (b) STLF-IA consistently presents superior behavior than STLF based on weather data and STLF based on individual load data; (c) MA reduces the occurrence of unsatisfactory single-algorithm STLF models, therefore enhancing the STLF robustness; (d) STLF-HA produces the most accurate forecasts in distinctive load pattern scenarios due to calendar effects.
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Liu, Chung Y., Dominic Chung, Earl Davie, and Leonard Chess. "FORMER STUDIES OF FIBRINOGEN NEW YORK I : ANALYSIS OF HE GENUINIC C DISORDER for the deletion OF MINO ACID SEQUENCE 9-72 OF THE Bβ CHAIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644697.

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Fibrinogens New York I and la (NY-I and NY-la) have been purified from blood plasma samples of a^ sister and a brother in a white family with thrombotic tendency. Both are heterozygous and contain both thrombin-clottable fibrinogen with two normal Bβ-chains and thrombin-nonclottable fibrinogen with two abnormal Bβ chains. The abnormal β-chains result- fran deletions of ammo acid residues 9-72, which are encoded exactly by exon II of the gene. To study the genomic disorder for this deletion, gencmic DNAs were isolated respectively from leukocytes of NY-la, NY-Ib (a nonaffected brother), and four normal individuals outside the NY-I family, and analysed in Southern blotting experiments with a human gencmic DNA probe containing exons I-V. Digestion of various DNAs were performed with two different restriction enzymes, and these digestions were analyzed respectively by agrose electroptoresis.Digestion with Hind III reveals 3 cleavage sites (one site in intron A near exon II)witn formation of two fragments of equal size (2 bands : 3.1kb and 3.1 kb) in normal, NY-la and NY-Id, but an extra fragment (one band = 6.0 kb) in NY-Ia.Digestion with Pvu II reveals 3 cleavage sites (one site in exonII) with formation of two fragments (2 bands : 7.5 kb and 2.9kb)m normal, NY-Ia and NY-Ib, but an extra fragment (one band - 5.7 kb) in NY-Ia. These results show that one Hind III and one Pvu II cleavage sites which are present in the normal allele are absent in the abnormal allele of NY-Ia. Thus, these studies indicate that generic disorder is associated with the patient (NY-Ia) with a thrombotic tendency, and further suggest that the genomic defect in the aonormal allele is near the junction of intron A and exon II. A possible mechanism for this genomic disorder is due to that an inverse double crossover have taken place in a region covering this junction, resulting in m abnormal RNA-splicing site in this junction. Thus, exon II is eliminated with intron A during RNA processing and absent in the abnormal rnRNA. Accordingly, the β(9-72) amino acid sequence disappears from one abnromal β-chains.
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8

Xiang, Jianping, Sabareesh K. Natarajan, Markus Tremmel, Ding Ma, J. Mocco, Adnan Siddiqui, Elad I. Levy, and Hui Meng. "Hemodynamic Metrics Correlate With Intracranial Aneurysm Rupture Status Better Than Morphologic Metrics." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19664.

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Given the considerable risk of treating unruptured intracranial aneurysms (IAs), as well as the known severe morbidity of aneurysm rupture, elucidating those aneurysms that require prophylactic treatment can be a quandary. Traditionally, decision-making to treat an unruptured aneurysm was largely based on the Size of the aneurysm, but recent studies have failed to show significant correlation of Size with IA rupture, and a large number of ruptured aneurysms are small in Size.[1] Consequently, shape-based morphologic metrics have been explored in current investigations, and complex shapes have been correlated with rupture.[1] With the advancement of 3D angiography, and computational fluid dynamics (CFD) technology, patient-specific hemodynamics analysis has become feasible. Intra-aneurysmal hemodynamic factors, including wall shear stress (WSS), impingement regions, and oscillatory shear index (OSI), have been proposed as indicators for IA rupture risk.[2, 3] No study has rigorously examined both morphology-based and hemodynamics-based parameters from a uniform cohort to compare their relative importance. Our aim, therefore, was to identify significant morphologic and hemodynamic parameters that correlate with an aneurysm’s rupture status and examine whether hemodynamic parameters can separate ruptured and unruptured aneurysms better than morphologic parameters.
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9

Morais, Luis César Dias, Celso De Renna E Souza, and Sérgio Roberto Matiello Pellegrino. "Uma Proposta para Gerência Pró-Ativa em Redes Utilizando Agentes Inteligentes Hierarquicamente Distribuídos." In III Simpósio Brasileiro de Sistemas de Informação. Sociedade Brasileira de Computação, 2006. http://dx.doi.org/10.5753/sbsi.2006.14753.

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Este artigo pretende descrever a criação de uma sociedade de agentes inteligentes hierarquicamente distribuídos, incumbidos de prover gerência pró-ativa a redes de computadores baseadas no padrão Ethernet, quando utilizando protocolos da camada de aplicação. Para que isto fosse possível são descritas as formas de como informações fornecidas pelas MIBs (Management Information Base) RMON2 (Remote Monitoring 2), SNMPv2 (Simple Network Management Protocol Version 2) entre outras foram concatenadas à técnicas de IA (Inteligência Artificial), IAD (Inteligência Artificial Distribuída) e SE (Sistemas Especialistas), que juntamente com a Linguagem Java e o Shell JESS (Java Expert System Shell) solucionaram de maneira eficaz diversos problemas comuns a redes.
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10

Fjeldberg, Egil Romsås, Yngve Bolstad Johansen, Lodve Hugo Olsborg, Geir Frode Kvilaas, Tor-Ole Jøssund, and Harish Datir. "X-RAY DIFFRACTION, X-RAY FLUORESCENCE, AND NEUTRON INDUCED SPECTROSCOPY BASED CORRECTION TO IVAR AASEN GEOMODEL: AN OILFIELD FROM THE NORWEGIAN NORTH SEA." In 2021 SPWLA 62nd Annual Logging Symposium Online. Society of Petrophysicists and Well Log Analysts, 2021. http://dx.doi.org/10.30632/spwla-2021-0042.

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The Ivar Aasen (IA) oilfield is located on the Gudrun Terrace on the eastern flank of the Viking Graben in the Norwegian North Sea. The field was discovered in 2008. The reservoir is located within a sedimentary sequence of Mid-Jurassic to Late-Triassic age, which consists of shallow marine to fluvial, alluvial, floodplain and lacustrine deposits overlying a regionally extensive, fractured calcrete interval. The sequence exhibits a complex mineral composition and is heterogeneous at a scale below that of a logging sensor. Shale layers, re-deposited shale and what was first believed to be redeposited calcrete fragments present in various forms throughout the sequence. Looking more in depth to XRD and XRF data and contrasting Fe concentration in the dolomite, it is also possible to explain some of the carbonate deposits through other processes. Extensive data acquisition in the form of advanced wireline logs and coring with analysis performed in “geopilot” wells before production start, enabled a novel thin bed formation evaluation technique based on the modified Thomas-Stieber method (Johansen et al. 2018). The method increased the in-place oil volumes within the Triassic reservoir zone internally named Skagerrak 2. This led to several improvements and a modified drainage strategy of Ivar Aasen. Several good producers were placed in the complex net of the Skagerrak 2 Formation. Results from these producers have encouraged development of an even more marginal and complex net, deeper into the Triassic sedimentary sequence. Therefore, another “geopilot” was drilled into the deeper Triassic sediments, internally named as the Alluvial Fan. This zone exhibits conglomerate clasts in a matrix varying between clay, silt, feldspars, and very fine to very coarse sand fractions, grading towards gravel. Previously, this zone was considered to be mostly non-net. Applying the same interpretation method as for Skagerrak 2, the Alluvial Fan promised economic hydrocarbon volumes. The latest geopilot proved producible hydrocarbons, and subsequently a producer was also successfully placed in this part of the reservoir. Production data and history matching from the beginning of production have for a long while established the previous increase of IA Triassic oil volumes published in 2018. Advanced studies of mineralogy and spectroscopy (Johansen et al. 2019) have indicated that a significant amount of the previously interpreted dolomite, could be reinterpreted as ferroan dolomite. The latter is a heavier mineral that increases the matrix density, hence also the total porosity. The additional findings described provided another necessary first-order correction to further enhance the evergreen geomodel. This paper describes this methodology which resulted in improved petrophysics and reservoir properties of the Alluvial Fan, yet again demonstrating the value of advanced wireline logs and detailed analysis that in total impacts the IA reserve volumes in a significant manner. Repeated success with the applied spectroscopy data and the thin bed methodology used today (Johansen et al. 2018), has resulted in even the deeper Braid Plain Formation becoming of economic interest. It is expected to lie within the oil zone in an upthrow block in the northern part of the IA field and could be developed into the next target.
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Reports on the topic "IA-2"

1

Zilberman, Mark. Shouldn’t Doppler 'De-boosting' be accounted for in calculations of intrinsic luminosity of Standard Candles? Intellectual Archive, September 2021. http://dx.doi.org/10.32370/iaj.2569.

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"Doppler boosting / de-boosting" is a well-known relativistic effect that alters the apparent luminosity of approaching/receding radiation sources. "Doppler boosting" alters the apparent luminosity of approaching light sources to appear brighter, while "Doppler de-boosting" alters the apparent luminosity of receding light sources to appear fainter. While "Doppler boosting / de-boosting" has been successfully accounted for and observed in relativistic jets of AGN, double white dwarfs, in search of exoplanets and stars in binary systems it was ignored in the establishment of Standard Candles for cosmological distances. A Standard Candle adjustment appears necessary for "Doppler de-boosting" for high Z, otherwise we would incorrectly assume that Standard Candles appear dimmer, not because of "Doppler de-boosting" but because of the excessive distance, which would affect the entire Standard Candles ladder at cosmological distances. The ratio between apparent (L) and intrinsic (Lo) luminosities as a function of redshift Z and spectral index α is given by the formula ℳ(Z) = L/Lo=(Z+1)^(α-3) and for Type Ia supernova as ℳ(Z) = L/Lo=(Z+1)^(-2). These formulas are obtained within the framework of Special Relativity and may require adjustments within the General Relativity framework.
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2

Zilberman, Mark. “Doppler de-boosting” and the observation of “Standard candles” in cosmology. Intellectual Archive, July 2021. http://dx.doi.org/10.32370/iaj.2549.

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“Doppler boosting” is a well-known relativistic effect that alters the apparent luminosity of approaching radiation sources. “Doppler de-boosting” is the name of relativistic effect observed for receding light sources (e.g. relativistic jets of active galactic nuclei and gamma-ray bursts). “Doppler boosting” changes the apparent luminosity of approaching light sources to appear brighter, while “Doppler de-boosting” causes the apparent luminosity of receding light sources to appear fainter. While “Doppler de-boosting” has been successfully accounted for and observed in relativistic jets of AGN, it was ignored in the establishment of Standard candles for cosmological distances. A Standard candle adjustment of an Z>0.1 is necessary for “Doppler de-boosting”, otherwise we would incorrectly assume that Standard Candles appear dimmer not because of “Doppler de-boosting” but because of the excessive distance, which would affect the entire Standard Candles ladder at cosmological distances. The ratio between apparent (L) and intrinsic (Lo) luminosities as a function of the redshift Z and spectral index α is given by the formula ℳ(Z) = L/Lo=(Z+1)α -3 and for Type Ia supernova appears as ℳ(Z) = L/Lo=(Z+1)-2. “Doppler de-boosting” may also explain the anomalously low luminosity of objects with a high Z without the introduction of an accelerated expansion of the Universe and Dark Energy.
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3

Zilberman, Mark. PREPRINT. “Doppler de-boosting” and the observation of “Standard candles” in cosmology. Intellectual Archive, June 2021. http://dx.doi.org/10.32370/ia_2021_06_23.

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PREPRINT. “Doppler boosting” is a well-known relativistic effect that alters the apparent luminosity of approaching radiation sources. “Doppler de-boosting” is the term of the same relativistic effect observed for receding light sources (e.g.relativistic jets of active galactic nuclei and gamma-ray bursts). “Doppler boosting” alters the apparent luminosity of approaching light sources to appear brighter, while “Doppler de-boosting” alters the apparent luminosity of receding light sources to appear fainter. While “Doppler de-boosting” has been successfully accounted for and observed in relativistic jets of AGN, it was ignored in the establishment of Standard candles for cosmological distances. A Standard candle adjustment of Z>0.1 is necessary for “Doppler de-boosting”, otherwise we would incorrectly assume that Standard Candles appear dimmer, not because of “Doppler de-boosting” but because of the excessive distance, which would affect the entire Standard Candles ladder at cosmological distances. The ratio between apparent (L) and intrinsic (Lo) luminosities as a function of the redshift Z and spectral index α is given by the formula ℳ(Z) =L/Lo=(Z+1)^(α-3) and for Type Ia supernova appears as ℳ(Z)=L/Lo=(Z+1)^(-2). “Doppler de-boosting” may also explain the anomalously low luminosity of objects with a high Z without the introduction of an accelerated expansion of the Universe and Dark Energy.
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4

Zilberman, Mark. "Doppler De-boosting" and the Observation of "Standard Candles" in Cosmology. Intellectual Archive, July 2021. http://dx.doi.org/10.32370/iaj.2552.

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Abstract:
“Doppler boosting” is a well-known relativistic effect that alters the apparent luminosity of approaching radiation sources. “Doppler de-boosting” is the same relativistic effect observed but for receding light sources (e.g. relativistic jets of AGN and GRB). “Doppler boosting” alters the apparent luminosity of approaching light sources to appear brighter, while “Doppler de-boosting” alters the apparent luminosity of receding light sources to appear fainter. While “Doppler de-boosting” has been successfully accounted for and observed in relativistic jets of AGN, it was ignored in the establishment of Standard candles for cosmological distances. A Standard Candle adjustment of Z>0.1 is necessary for “Doppler de-boosting”, otherwise we would incorrectly assume that Standard Candles appear dimmer, not because of “Doppler de-boosting” but because of the excessive distance, which would affect the entire Standard Candles ladder at cosmological distances. The ratio between apparent (L) and intrinsic (Lo) luminosities as a function of the redshift Z and spectral index α is given by the formula ℳ(Z) = L/Lo=(Z+1)α -3 and for Type Ia supernova appears as ℳ(Z) = L/Lo=(Z+1)-2. “Doppler de-boosting” may also explain the anomalously low luminosity of objects with a high Z without the introduction of an accelerated expansion of the Universe and Dark Energy.
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