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McFarlane, S., and E. Cooper. "Kinetics and voltage dependence of A-type currents on neonatal rat sensory neurons." Journal of Neurophysiology 66, no. 4 (October 1, 1991): 1380–91. http://dx.doi.org/10.1152/jn.1991.66.4.1380.
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1. We have characterized three voltage-gated potassium currents on neonatal rat nodose neurons: a rapidly inactivating current (IAf), a slowly inactivating current (IAs), and a noninactivating current (IK). 2. Most neurons expressed all three currents. However, we found that a significant number of neurons had only one of the two A-currents. 3. IAf activates rapidly (tau = 1.0-1.5 ms at -10 mV) and inactivates in 10-30 ms. The activation and steady-state inactivation curves were fit with Boltzmann distributions of V' = -21, k = 12 mV and V' = -73, k = -8 mV, respectively. 4. IAs activates more slowly than IAf (tau = 5.4-9.2 ms at -10 mV) and inactivates with two components (150-300 ms; 1-3 s). The activation and inactivation curves are shifted approximately 20 mV more positive than those of IAf, with Boltzmann coefficients of V' = -2, k = 14 mV and V' = -51, k = -14 mV, respectively. 5. Of the three, IK activates most slowly (tau = 29.4-38.3 ms at -10 mV) and at more positive potentials than IAf or IAs (V' = 16, k = 12 mV). IK does not inactivate over tens of seconds. 6. In addition, we have identified the single channels that underlie IAf and IAs. These two channels, Af and As, have the same single-channel conductance, 22 pS, but different inactivation kinetics. 7. Furthermore, we show that there is an inverse relationship between the appearance of A-currents (IAf and IAs) and the appearance of IK, suggesting that these neurons coordinate the expression of these currents in their membranes.
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DEMIRBAS, Mahmut, and Yunus SANSAR. "Mali Tablolarin Fasb 52, Ias 21 Ve Tms 21 Dogrultusunda Yabanci Para Cinsinden İfade Edilmesi." Istanbul Aydin Universitesi Dergisi 7, no. 28 (November 1, 2015): 41–52. http://dx.doi.org/10.17932/iau.iaud.m.13091352.2015.7/28.41-52.
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Sultana, M., and ZH Hashim. "Invasive Alien Fish Species in Freshwater of the Continents." Journal of Environmental Science and Natural Resources 8, no. 2 (February 29, 2016): 63–74. http://dx.doi.org/10.3329/jesnr.v8i2.26868.
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This review article presents the updated informationof freshwater Invasive Alien Species (IAS) of fishes of the continents to understand the homogenate progression in global freshwater ecosystems and the leading pathways of freshwater IAS fish introduction throughout the continents. North America contains 45 freshwater invasive fish species within 18 families, which is the most profuse off all other continents, whereas, Australia possesses the lowermost amount of freshwater IAS fish, 18 species under 8 families. Besides, Asia retains 41 freshwater IAS fish under 14 families and Europe acquires 32 species under 18 families. The uppermost spreader IAS fish family is Cyprinidae followed by Cichlidae subsequently. Nine common fishes (Carassius auratus, Cyprinus carpio, Onchorynchus mykiss, Oreochromis mossambicus, Poecilia reticulata, Salmo salar, Salmo trutta and Salvelinusfontinalis) turned out invasive in all the continents (without Antarctica). Among IAS introduction pathways, aquaculture causes the highest percentage of freshwater IAS introduction in all continents. Aquaculture root 25% of IAS fish introduction in Africa, 21% in Asia, 19% in Australia, 20% in Europe, 19% in North America and 19% in South America. There is hardly any documentation on freshwater IAS fishes of Antarctica. Therefore, future research consideration may be designed.J. Environ. Sci. & Natural Resources, 8(2): 63-74 2015
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Halbouni, Sawsan Saadi, and Asifa Yasin. "Risk Disclosure: Empirical Investigation of UAE Companies’ Compliance with International Accounting Standards." International Journal of Business and Management 11, no. 8 (July 20, 2016): 134. http://dx.doi.org/10.5539/ijbm.v11n8p134.
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This paper empirically investigates the degree of compliance with International Accounting Standards (IAS 21) Foreign Currencies Translation, which is a proxy for risk disclosure by public companies in the United Arab Emirates (UAE). The current study also examines potential factors, which might be affecting risk disclosure through utilizing IAS 21 voluntary disclosure indicator checklist to find risk disclosure by 52 companies listed on UAE stock markets for 2011 and 2012. In addition, regression analysis tests are applied to determine factors affecting risk disclosure. The results indicate a low level of risk disclosure demonstrated by companies understudy, a significant impact of business type on risk disclosure, and a negative significant impact of company age on risk disclosure. Furthermore, the results show that size, profitability, type of audit firm, and liquidity, they all had insignificant impact on risk disclosure as to the UAE sample understudy. In general, the findings show a low degree of compliance with IAS 21 Foreign Currency Translation by companies in the UAE, suggesting a serious overseers' intervention and corporate governance to guarantee quality financial reporting produced by UAE-listed firms.
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Chihi, Mehdi, Oliver Gembruch, Marvin Darkwah Oppong, Bixia Chen, Thiemo Florin Dinger, Lennart Barthel, Daniela Pierscianek, et al. "Intracranial aneurysms in patients with tuberous sclerosis complex: a systematic review." Journal of Neurosurgery: Pediatrics 24, no. 2 (August 2019): 174–83. http://dx.doi.org/10.3171/2019.2.peds18661.
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OBJECTIVETuberous sclerosis complex (TSC) is a rare multisystem genetic disease. Arterial wall developmental disorders, such as aneurysms, in association with TSC have been well described for extracranial vasculature. The characteristics of intracranial aneurysms (IAs) in TSC have not previously been addressed in the literature. This systematic review was performed to identify and assess the distinct characteristics of IAs in patients with TSC.METHODSThe authors searched PubMed, Scopus, and Web of Science for publications describing cases of TSC and IA reported before August 7, 2018. They also report 2 cases of IAs in TSC patients treated at their own institution.RESULTSThirty-three TSC patients with a total of 42 IAs were included in this review. Three individuals presented with subarachnoid hemorrhage. The IAs were large or giant in 57.1% and fusiform in 45.2% of the cases. Most of the IAs (61.9%, 26 of 42) originated from the internal carotid artery. There was a higher prevalence of pediatric cases (66.7%) and male patients (63.6%, 21 of 32 individuals with known sex) among the collected series.CONCLUSIONSTSC patients with IAs are characterized with a higher proportion of large/giant and fusiform IAs and young age, suggesting rapid aneurysmal growth. Furthermore, there is a distinct location pattern of IAs and an inverse sex ratio than in the healthy population. Large population-based patient registers are required to improve the understanding of epidemiology and pathophysiology of IA formation in TSC.
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Saccol, Ailo Valmir, and Lindolfo Storck. "ANÁLISE DE ESTABILIDADE FENOTÍPICA DE CULTIVARES DE SOJA EM 28 AMBIENTES DO RIO GRANDE DO SUL." Ciência Rural 23, no. 2 (August 1993): 145–49. http://dx.doi.org/10.1590/s0103-84781993000200004.
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O presente estudo utilizou os dados de rendimento de 21 cultivares de soja, em 28 ambientes do Rio Grande do Sul, para uma análise de estabilidade pelo modelo bi-segmentado descontínuo (STORCK, 1989), com correções devido a erros nas variáveis. As principais conclusões foram; 1) O método mostrou-se adequado para o estudo da estabilidade fenotípica de cultivares de soja, porque houve uma boa variação ambiental e um bom ajustamento dos dados ao modelo; 2) O grupo de cultivares estudado pode ser classificado em: a) Indesejáveis (Hill, IAS-2, Paraná, Prata, Sel. Foscarin, Louisiana, Hardee, Bienville, Industrial, Santa Rosa, Bossier e Viçoja); b) Adaptáveis tanto aos ambientes inferiores como aos superiores, dentro da região estudada (Pérola, Bragg e Jakson); c) Adaptáveis à ambientes superiores (Planalto, Hale-7, IAS-5, IAS-1 e IAS-4); d) Adaptáveis à ambientes médios (Hood).
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Harris, Philippa, Richard Henderson, and Peter Hayward. "Highlights from the 11th IAS Conference on Science." Lancet HIV 8, no. 8 (August 2021): e459. http://dx.doi.org/10.1016/s2352-3018(21)00161-2.
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Essl, Franz, Bernd Lenzner, Franck Courchamp, Stefan Dullinger, Jonathan M. Jeschke, Ingolf Kühn, Brian Leung, Dietmar Moser, Núria Roura-Pascual, and Hanno Seebens. "Introducing AlienScenarios: a project to develop scenarios and models of biological invasions for the 21 st century." NeoBiota 45 (April 15, 2019): 1–17. http://dx.doi.org/10.3897/neobiota.45.33366.
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AlienScenarios, a three-year project starting in March 2019, will evaluate for the first time the range of plausible futures of biological invasions for the 21st century. AlienScenarios consists of seven project partners and seven integrated complementary subprojects. We will develop the qualitative narratives for plausible futures of global alien species richness and impacts in the 21st century – the Alien Species Narratives (ASNs). The ASNs further serve as overarching concept to parameterize quantitative models of global, continental and regional futures of biological invasions. We will also establish the first global mechanistic invasion model considering major processes of biological invasions such as source pools, driver dynamics and establishment rates. Further, we will assess the impacts of invasive alien species (IAS) in terms of economic costs according to the different ASNs. In addition, we will assess the consequences of different levels of implementation of the European Union Regulation on IAS. Providing some more detailed regional information, we will analyse changes of the functional composition of communities in mountain regions under different scenario storylines and will extend the analyses to the Global South using Panama as a country-level case study. Finally, the results of the other WPs will be synthesized, and the approach and results of AlienScenarios will be discussed with and communicated to stakeholders and the wider community. AlienScenarios will provide crucially needed insights for pro-active alien species management and policy. It will thus make an important contribution to global assessments and projections of biodiversity and ecosystem services, as well as regional policies (e.g. EU regulation on IAS).
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Deniz, E. Asena. "IAS 21-The effects of changes in foreign exchange rates-an example of Pegasus." Pressacademia 7, no. 1 (September 1, 2018): 437–41. http://dx.doi.org/10.17261/pressacademia.2018.930.
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Kühn, Anna Luisa, Katyucia de Macedo Rodrigues, J. Diego Lozano, David E. Rex, Francesco Massari, Takamitsu Tamura, Mary Howk, et al. "Use of the Pipeline embolization device for recurrent and residual cerebral aneurysms: a safety and efficacy analysis with short-term follow-up." Journal of NeuroInterventional Surgery 9, no. 12 (November 25, 2016): 1208–13. http://dx.doi.org/10.1136/neurintsurg-2016-012772.
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ObjectiveEvaluation of the safety and efficacy of the Pipeline embolization device (PED) when used as second-line treatment for recurrent or residual, pretreated ruptured and unruptured intracranial aneurysms (IAs).MethodsRetrospective review of our database to include all patients who were treated with a PED for recurrent or residual IAs following surgical clipping or coiling. We evaluated neurological outcome and angiograms at discharge, 6- and 12-months’ follow-up and assessed intimal hyperplasia at follow-up.ResultsTwenty-four patients met our inclusion criteria. Most IAs were located in the anterior circulation (n=21). No change of preprocedure modified Rankin Scale score was seen at discharge or at any scheduled follow-up. Complete or near-complete aneurysm occlusion on 6- and 12-month angiograms was seen in 94.4% (17/18 cases) and 93.3% (14/15 cases), respectively. Complete or near-complete occlusion was seen in 100% of previously ruptured and 85.7% (6/7 cases) and 83.3% (5/6 cases) of previously unruptured cases at the 6- and 12-months’ follow-up, respectively. One case of moderate intimal hyperplasia was observed at 6 months and decreased to mild at the 12-months’ follow-up. No difference in device performance was observed among pretreated unruptured or ruptured IAs.ConclusionsTreatment of recurrent or residual IAs with a PED after previous coiling or clipping is feasible and safe. There is no difference in device performance between ruptured or unruptured IAs.
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DUARTE, PAULO S., HONGMING ZHUANG, DAVID KING, and ABASS ALAVI. "Hipometabolismo cerebral em pacientes com esclerose mesial temporal demonstrado pelo FDG-PET." Arquivos de Neuro-Psiquiatria 58, no. 3B (September 2000): 869–76. http://dx.doi.org/10.1590/s0004-282x2000000500012.
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O objetivo deste estudo foi avaliar a extensão do hipometabolismo cerebral em pacientes com esclerose mesial temporal (EMT). MÉTODO: Este estudo retrospectivo incluiu 21 pacientes que apresentavam epilepsia parcial complexa refrataria à terapia e que foram selecionados para cirurgia após análise extensa que incluía: EEG de superfície e estudos de neuroimagem (PET, SPECT e ressonância magnética). Todos os pacientes foram submetidos a intervenção cirúrgica e tiveram confirmação histológica de EMT. Uma análise semi-quantitativa foi realizada, utilizando regiões de interesse (ROIs) nas seguintes estruturas: lobos frontais, parietais e occipitais, gânglios da base, tálamos, cerebelo e três diferentes regiões nos lobos temporais, que compreendiam o córtex medial, inferior e lateral. Um índice de assimetria (IA) foi calculado, comparando as contagens por pixel nas estruturas homólogas em ambos os hemisférios cerebrais. Os IAs das diferentes estruturas foram então correlacionados. RESULTADOS: Uma correlação significativa foi demonstrada entre os IAs do córtex medial dos lobos temporais e aqueles dos lobos frontais, dos lobos parietais, dos gânglios da base e dos tálamos (r = 0,72, 0,62, 0,47 e 0,47 respectivamente com p < 0,05 ). Foi demonstrada correlação altamente significativa dos IAs das 3 regiões do lobo temporal entre si (chegando a 0,86 entre os IAs das regiões mediais do lobo temporal e os IAs das regiões inferiores). CONCLUSÃO: Esses dados indicam que o hipometabolismo se estende além do foco epiléptico no lobo temporal em pacientes com epilepsia parcial complexa relacionada a EMT. O metabolismo na porção medial do lobo temporal é mais correlacionado com o metabolismo no lobo frontal do que com aquele de outras estruturas cerebrais externas aos lobos temporais. Os mecanismos fisiopatológicos envolvidos no hipometabolismo continuam controversos.
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Shapira, Michael Y., Sheth Vipul, Alexander Klimov, Sigal Griesaro, Panagiotis Tsirigotis, Batia Ronit Avni, Reuven Or, and Allan Bloom. "Regional Intra-Arterial Steroid Treatment in 113 Patients with Steroid Resistant or Dependent Graft-Versus-Host Disease." Blood 128, no. 22 (December 2, 2016): 62. http://dx.doi.org/10.1182/blood.v128.22.62.62.
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Abstract Introduction : Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation (BMT), resulting in death in the majority of steroid-resistant patients. In the past 15 years, we revolutionized the use of interventional radiology procedures in the field of stem cell transplantation. This study was aimed to assess the efficacy of regional intra-arterial steroid (IAS) treatment in the largest published cohort of patients with resistant/dependent hepatic and/or gastrointestinal (GI) GVHD. In total, 113 patients with steroid resistant or dependent grade 3-4 hepatic (n = 21), gastrointestinal (GI) (n = 62) GVHD or both (n = 30) were given intra-arterial treatment. Patients and methods: Patients with liver GVHD received IAS in hepatic artery and patients with gastrointestinal GVHD received IAS in the superior and inferior mesenteric as well as the internal iliac arteries. Patients with pronounced upper GI symptoms also received IAS to the gastroduodenal artery. In total 148 procedures were carried out (range 1-3 per patient). Results : Partial responses were observed in 33 out of 51 (65%) patients with hepatic GVHD, out of which (55%) had complete response. Median time to complete response was 45 days (range - 5 to 300 days). For GI GVHD complete responses were observed in 69 out of 92 (75%) and partial responses were observed in 76 out of 92 (83%). The median time to complete response was 20 days (range - 3 to 200 days ). As this is the largest published cohort of regional IAS therapy for GVHD, multivariate and univariate analysis was done in order to identify the patients with highest chance of response. Conclusions : Regional treatment of severe GVHD with IAS treatment is effective and safe. GI treatment is more effective than intrahepatic treatment. Early administration of isolated intra-arterial therapy in high-risk patients may further improve the outcome and reduce untoward effects of prolonged systemic immunosuppressive treatment. Figure 1. Figure 1. Figure 2. Figure 2. Disclosures No relevant conflicts of interest to declare.
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Goldenberg, Neil A., R. Knapp-Clevenger, Linda Jacobson, Taru Hays, Santica M. Marcovina, and Marilyn J. Manco-Johnson. "Investigating Lipoprotein(A) as a Risk Factor for Ischemic Arterial Stroke in U.S. Children. New Understanding from a Case-Control Study with Gold-Standard Laboratory Assessment." Blood 106, no. 11 (November 16, 2005): 2627. http://dx.doi.org/10.1182/blood.v106.11.2627.2627.
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Abstract Background: Lipoprotein(a) [Lp(a)] is a plasma lipoprotein that has been implicated in both atherogenesis and thrombophilia. A few reports in recent years, principally in European populations, have suggested that elevated plasma Lp(a) level may constitute a risk factor for ischemic arterial stroke (IAS) in children. However, the ELISA assays used in these studies are technically limited by their ability to provide accurate Lp(a) values independently of apo(a) size. Objective: To determine the prevalence of elevated plasma Lp(a) concentration among children with non-neonatal IAS and healthy children in a U.S. population using the current gold-standard laboratory methodology, toward the evaluation of Lp(a) as a risk factor for pediatric IAS. Methods: In a case-control study, children from 1 month to 21 years of age with a history of radiologically-confirmed IAS (case group, n=22) and healthy children (contemporaneous control group, n=41) were consecutively recruited from The Children’s Hospital, Denver, and the Mountain States Regional Hemophilia and Thrombosis Center (Aurora, CO). Children with IAS who were receiving drugs that affect Lp(a) level, such as niacin or statins, were excluded. Fasting plasma samples were obtained by peripheral venipuncture into EDTA with susequent centrifugation to yield platelet-poor plasma. Lp(a) assay was performed in the Northwest Lipid Metabolism and Diabetes Research Laboratories at the University of Washington, Seattle, using a double monoclonal antibody-based ELISA validated to be sensitive to apo(a) size heterogeneity. Results were expressed in nmol/L of Lp(a) protein, with corresponding race-appropriate percentiles. In accordance with NHLBI recommendations, values above the 75th percentile were considered to indicate increased risk, and were hence designated as elevated. Results: Median Lp(a) concentration did not significantly differ between the two groups (cases: 16.9 nmol/L, controls: 24.7 nmol/L; P=0.96). While the prevalence of elevated Lp(a) levels was increased among children with IAS (cases: 36%, controls: 24%), this difference did not reach statistical significance (P=0.32). The odds of having elevated Lp(a) were nearly two times that of healthy controls (OR=1.8, 95% CI=0.50–6.3); however, this also was not statistically significant. Conclusions: The present study demonstrates a qualitatively increased prevalence of elevated plasma Lp(a) concentration among children with non-neonatal IAS when compared to healthy children, using the gold-standard methodology for Lp(a) assessment. Expansion of the study to a larger population via multicenter collaboration will be necessary to definitively determine whether Lp(a) is a risk factor for IAS in children. Furthermore, given that genetic variation in the apo(a) gene is the major determinant of plasma Lp(a) concentration, apo(a) phenotyping may be useful to better define risk strata. These efforts are an important precursor to interventional studies evaluating Lp(a) management strategies in the secondary prevention of IAS in children.
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Topuria, Nika, and Omar Kikvidze. "Application of Genetic Algorithm in Common Optimization Problems." International Annals of Science 8, no. 1 (July 21, 2019): 17–21. http://dx.doi.org/10.21467/ias.8.1.17-21.
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Use of non-deterministic algorithms for solving multi-variable optimization problems is widely used nowadays. Genetic Algorithm belongs to a group of stochastic biomimicry algorithms, it allows us to achieve optimal or near-optimal results in large optimization problems in exceptionally short time (compared to standard optimization methods). Major advantage of Genetic Algorithm is the ability to fuse genes, to mutate and do selection based on fitness parameter. These methods protect us from being trapped in local optima (Most of deterministic algorithms are prone to getting stuck on local optima). In this paper we experimentally show the upper hand of Genetic Algorithms compared to other traditional optimization methods by solving complex optimization problem.
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Csiszár, Ágnes, Pál Kézdy, Márton Korda, and Dénes Bartha. "Occurrence and management of invasive alien species in Hungarian protected areas compared to Europe." Folia Oecologica 47, no. 2 (November 1, 2020): 178–91. http://dx.doi.org/10.2478/foecol-2020-0021.
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AbstractA questionnaire survey was carried out to examine the problems caused by invasive alien species (IAS) in Hungarian protected areas (PAs). Results from 144 PAs were evaluated and compared with a previous study of 21 European countries. In the European survey, the most important threats were habitat loss and fragmentation, Hungarian respondents put IAS in first place. Eradication, control and prevention were mentioned among the best strategies against invasive species in both surveys, but Hungarian PA managers emphasized the efficiency of habitat restoration and regulatory as well. Comparing the harmful animals and plants occurring in most Hungarian and European PAs, we found nearly 30% similarity. In most Hungarian PAs domestic cat (Felis catus Linnaeus, 1758) and black locust (Robinia pseudoacacia L.) were indicated as most harmful species. The results of our study draw the attention to the species, which are highly invasive in Hungary, but are missing from the European PAs list, therefore may pose a potential threat to other protected areas of Europe.
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Kleitou, Periklis, Jason M. Hall-Spencer, Ioannis Savva, Demetris Kletou, Margarita Hadjistylli, Ernesto Azzurro, Stelios Katsanevakis, et al. "The Case of Lionfish (Pterois miles) in the Mediterranean Sea Demonstrates Limitations in EU Legislation to Address Marine Biological Invasions." Journal of Marine Science and Engineering 9, no. 3 (March 15, 2021): 325. http://dx.doi.org/10.3390/jmse9030325.
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The European Regulation (EU) 1143/2014 on Invasive Alien Species entered into force in 2015, with the aim to fulfill regional and international biodiversity goals in a concerted manner. To date, the Regulation listed 66 Invasive Alien Species (IAS) that are subject to legal controls. Only one of these is marine. A recent lionfish (Pterois miles) invasion has been closely monitored in the Mediterranean and a detailed risk assessment was made about the profound impacts that this invasive fish is likely to have on the fisheries and biodiversity of the region. In 2016–21, lionfish rapidly became dominant predators along Eastern Mediterranean coasts, yet the process for their inclusion on the EU IAS list has been lengthy and is ongoing. There is an urgent need to learn from this experience. Here, we recommend improvements to the Regulation 1143/2014 and the risk assessment process to protect marine ecosystems and secure the jobs of people that rely on coastal resources.
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Kota, Lalitha, Mary Osborne-Pellegrin, Herbert Schulz, Jacques Behmoaras, Michèle Coutard, Maolian Gong, and Norbert Hübner. "Quantitative genetic basis of arterial phenotypes in the Brown Norway rat." Physiological Genomics 30, no. 1 (June 2007): 17–25. http://dx.doi.org/10.1152/physiolgenomics.00209.2006.
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The Brown Norway (BN) rat presents several genetically determined arterial phenotypes of interest, i.e., ruptures of the internal elastic lamina (RIEL) in the abdominal aorta (AA), iliac (IAs), and renal arteries, aortic elastin deficit and higher frequency of persistent ductus arteriosus (PDA) than other strains. We investigated the genetic basis of these phenotypes. We established a backcross between BN and the LOU reference strain and performed a genome-wide scan on 104 males and 105 females with 193 microsatellite markers followed by linkage analysis. RIEL in AA and IAs showed highly significant linkage to a locus on chromosome 5 and suggestive linkage to a locus on chromosome 10, which is syntenic to one linked to a syndrome of thoracic aortic aneurysms with PDA in humans. In contrast, renal artery RIEL mapped to a chromosome 3 locus and thoracic aortic elastic content to two loci on chromosome 2. PDA was significantly linked to two different quantitative trait loci (QTL) on chromosomes 8 and 9. This is the first study in rats to identify genetic loci for PDA. We identified 21 candidate genes by functional relevance or integration of our mapping data with global expression analysis. Sequencing these genes identified 47 single nucleotide polymorphisms, but no functionally relevant amino acid changes. By expression analysis, myosin heavy chain 10, nonmuscle, in the chromosome 10 QTL, emerged as a candidate for RIEL in AA and IAs. Furthermore, production of a congenic line for the chromosome 5 QTL proved implication of this locus in RIEL formation.
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Hasslacher, Christoph, and Justo Lorenzo Bermejo. "Treatment with insulin analogs and prevalence of cardiovascular complications in patients with type 1 diabetes." Therapeutic Advances in Endocrinology and Metabolism 8, no. 11 (October 10, 2017): 149–57. http://dx.doi.org/10.1177/2042018817732732.
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Background: A lower incidence of cardiovascular events has been reported in type 2 diabetes patients treated with insulin analogs (IAs). Corresponding data on people affected by type 1 diabetes are not available yet. Methodology: We investigated demographic and clinical data from 509 type 1 diabetics, who were treated in an outpatient clinic from 2006 to 2012. Multiple logistic regression was used to investigate the relationship between the type of insulin treatment and the prevalence of cardiovascular (CV) complications, that is, presence of coronary heart, cerebrovascular and peripheral arterial diseases, adjusting for potential confounders. Results: Results from multiple logistic regression revealed that patients with impaired renal function [estimated glomerular filtration rate (eGFR) < 90 ml/min] show lower CV complication rates when treated with IAs (25%) compared with patients treated with human insulin (HI; 28%) and HI/IA (38%, p = 0.06). CV complication rates in the complete patient collective amounted to 17% (IA), 21% (HI) and 21% (HI/IA, p = 0.08). Examination of CV complications according to the type of IA revealed the lowest complication rates in type 1 diabetics treated with insulin lispro (5.9%) and glargine (16%). However, complication rate differences among insulin treatments did not reach statistical significance. Conclusion: The present cross-sectional study shows a borderline significantly lower CV morbidity in people with type 1 diabetes and impaired renal function when treated with IA compared with HI treatment after adjustment for multiple potential confounders [odds ratio (OR) = 0.78, which translates into a 22% lower complication rate]. Validation of these preliminary findings in confirmatory, prospective studies may have important clinical implications.
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Psomas, Christina K., Laura Waters, Tristan Barber, Sarah Fidler, Malcolm Macartney, Jasmini Alagaratnam, Buddhika Perera, and Sabine Kinloch. "Highlights of the 10th International AIDS Society (IAS) Conference on HIV Science, 21–25 July 2019, Mexico City, Mexico." Journal of Virus Eradication 5, no. 4 (October 2019): 245–52. http://dx.doi.org/10.1016/s2055-6640(20)30035-2.
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Sciortino, Giuseppa, Emanuela Orlandi, Cesare Valenti, and Domenico Tegolo. "WAVELET ANALYSIS AND NEURAL NETWORK CLASSIFIERS TO DETECT MID-SAGITTAL SECTIONS FOR NUCHAL TRANSLUCENCY MEASUREMENT." Image Analysis & Stereology 35, no. 2 (April 14, 2016): 105. http://dx.doi.org/10.5566/ias.1352.
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We propose a methodology to support the physician in the automatic identification of mid-sagittal sections of the fetus in ultrasound videos acquired during the first trimester of pregnancy. A good mid-sagittal section is a key requirement to make the correct measurement of nuchal translucency which is one of the main marker for screening of chromosomal defects such as trisomy 13, 18 and 21. NT measurement is beyond the scope of this article. The proposed methodology is mainly based on wavelet analysis and neural network classifiers to detect the jawbone and on radial symmetry analysis to detect the choroid plexus. Those steps allow to identify the frames which represent correct mid-sagittal sections to be processed. The performance of the proposed methodology was analyzed on 3000 random frames uniformly extracted from 10 real clinical ultrasound videos. With respect to a ground-truth provided by an expert physician, we obtained a true positive, a true negative and a balanced accuracy equal to 87.26%, 94.98% and 91.12% respectively.
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Frootan, Mojgan, Ainaz Sourati, Morteza Tabatabaeefar, Mohammad Reza Nikshoar, and Ali Mohammad Faizei. "Endosonographic features of rectal cancer: A single-center experience in Iran." Journal of Digestive Endoscopy 07, no. 01 (January 2016): 011–14. http://dx.doi.org/10.4103/0976-5042.180087.
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Abstract Context: Colorectal cancer is the fourth leading cause of cancer death worldwide. Aim: The study aim was to describe an endosonographic feature of rectal cancer in Iranian patients. Settings and Design: A retrospective study in Mehrad Hospital, Tehran, Iran. Materials and Methods: In this case series, all patients with confirmed diagnosis of rectal cancer during 2012–2014 were included and their hospital records were reviewed. Results: Hospital records of 76 patients with rectal cancer including 44 male (57.9%) and 32 females (42.1%) were reviewed. The mean age of patients was 57.81 ± 14.26 years. The distal rectum was the most common location of the tumor (42 patients, 55.3%) and complete luminal obstruction was observed in 11 patients (14.5%). Sphincters were free of disease in 70% of patients (53), while lymph nodes were involved in more than 70% of patients at diagnosis. Internal anal sphincter (IAS) alone was the most common sphincter involved (16 patients, 21%) followed by involvement of all three sphincters together (IAS and external anal sphincter and longitudinal muscle) (5, 6.6%). Conclusion: The mean age at diagnosis of rectal cancer in our country is less than that of Western countries. Lower rectum is the most common location of rectal cancer in our patients and lymph node metastasis is present in more than 70% of patients at the time of diagnosis.
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Maia, Maria Clideana Cabral, Natal Antonio Vello, Lúcio Borges de Araújo, Carlos Tadeu dos Santos Dias, Luis Cláudio de Oliveira, and Maurisrael De Moura Rocha. "Interação genótipo-ambiente em soja via análise de componentes principais com múltiplas matrizes de dados." REVISTA AGRO@MBIENTE ON-LINE 8, no. 1 (May 2, 2014): 104. http://dx.doi.org/10.18227/1982-8470ragro.v8i1.1369.
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O melhoramento da soja (Glycine max) está avançado, porém, não se obteve atingir o seu limiar produtivo, a despeito de sua base genética restrita é esperado avanço significativo com o melhoramento genético na obtenção de novos cultivares com altos níveis produtivos. Objetivou-se com este trabalho investigar a interação genótipo x ambiente em soja por meio da análise de componentes principais com múltiplas matrizes de dados. Foram avaliados 44 e 23 genótipos, nos anos agrícolas 2000 e 2001, respectivamente. Utilizou-se o delineamento de blocos aos acaso, com duas repetições estratificadas em três conjuntos experimentais com testemunhas comuns (IAC 100, Ocepar 4, IAS 5 e Primavera). Os fatores considerados para a análise foram: genótipos (G1, G2, G3..., G44), ambientes (combinação dos locais Anhembi-AN e Areão-AR com o controle intensivo-COM e ecológico-SEM de insetos) e atributos (produção e componentes). O estudo foi implementado por meio de análise de componentes principais com arranjo de três entradas (genótipo x ambiente x variáveis). Os genótipos 2, 3, 23, 28, 36, 38 e 44 apresentam tolerância a percevejos e boa produtividade no ambiente AN_COM. Os genótipos 7, 17, 21, 29, 35, 37 e 40 interagem positivamente com o ambiente AR_SEM com adaptabilidades e estabilidades específicas redundando em produtividades elevadas.
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Bellino, Francesca. "The Archive of Paul E. Kahle in Turin." Intellectual History of the Islamicate World 9, no. 1-2 (July 20, 2020): 102–13. http://dx.doi.org/10.1163/2212943x-20201003.
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Abstract This paper was written to commemorate the scholar of the Hebrew Bible and the philologist Bruno Chiesa (1949–2015) at the conference on “The Arabic Literary Genizot beyond Denominational Borders” (held at IAS, Princeton, NJ April 20–21, 2017). During his career, Chiesa edited various Judeo-Arabic documentary sources, especially some missing works by al-Qirqisānī (active 1oth century), and investigated the Geniza works as part of his studies on the historical philology of the Hebrew Bible. In the last years of his life, Chiesa has been involved in the cataloguing of the Hebrew and Arabic manuscripts held at the National Library of Turin and in the studying of the documents preserved in the archive of Paul E. Kahle of the University of Turin.
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Habanec, Petr. "Relationship Between Deferred Tax Category and Stock Prices in Pharmacy." Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis 66, no. 6 (2018): 1469–75. http://dx.doi.org/10.11118/actaun201866061469.
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The paper deals with relationship between stock prices and deferred tax category. Joos, Pratt and Young provided evidence that book‑tax differences are correlated with earning management. In this paper is confirmed negative relationship between stock prices and deferred tax. The relationship is assessed on sample of companies making business in pharmacy (CZNACE‑C‑21). The relationship between deferred tax category and stock prices is assessed on a sample of companies in the time series from 2005 to 2015. Sample consists of companies listed on Frankfurt stock exchange and reporting in accordance with international accounting standards IAS/IFRS. The stock prices dataset is based on Morningstar database. The results are compared with the results of author ’s previous study concerning the deferred tax materiality.
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Ding, Xinghuan, Sen Zhao, Qianqian Zhang, Zihui Yan, Yang Wang, Yong Wu, Xiaoxin Li, et al. "Exome sequencing reveals a novel variant in NFX1 causing intracranial aneurysm in a Chinese family." Journal of NeuroInterventional Surgery 12, no. 2 (August 10, 2019): 221–26. http://dx.doi.org/10.1136/neurintsurg-2019-014900.
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BackgroundGenetic risk factors play an important role in the pathogenesis of familial intracranial aneurysms (FIAs); however, the molecular mechanisms remain largely unknown.ObjectiveTo investigate potential FIA-causing genetic variants by rare variant interrogation and a family-based genomics approach in a large family with an extensive multigenerational pedigree with FIAs.MethodExome sequencing (ES) was performed in a dominant likely family with intracranial aneurysms (IAs). Variants were analyzed by an in-house developed pipeline and prioritized using various filtering strategies, including population frequency, variant type, and predicted variant pathogenicity. Sanger sequencing was also performed to evaluate the segregation of the variants with the phenotype.ResultsBased on the ES data obtained from five individuals from a family with 7/21 living members affected with IAs, a total of 14 variants were prioritized as candidate variants. Familial segregation analysis revealed that NFX1 c.2519T>C (p.Leu840Pro) segregated in accordance with Mendelian expectations with the phenotype within the family—that is, present in all IA-affected cases and absent from all unaffected members of the second generation. This missense variant is absent from public databases (1000genome, ExAC, gnomAD, ESP5400), and has damaging predictions by bioinformatics tools (Gerp ++ score = 5.88, CADD score = 16.43, MutationTaster score = 1, LRT score = 0). In addition, 840Leu in NFX1 is robustly conserved in mammals and maps in a region before the RING-type zinc finger domain.ConclusionNFX1 c.2519T>C (p.Leu840Pro) may contribute to the pathogenetics of a subset of FIAs.
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Schlünzen Junior, Klaus, Elisa Tomoe Moriya Schlünzen, Jeong Cir Deborah Zaduski, Sandra Giovina Ponzio, and Maria Claudia Leme Lopes da Silva. "Educação Integral, Híbrida e Inclusiva na perspectiva Construcionista, Contextualizada e Significativa (CCS)." Revista Interamericana de Investigación, Educación y Pedagogía, RIIEP 13, no. 1 (December 17, 2019): 157–75. http://dx.doi.org/10.15332/25005421/5465.
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Nas demandas do século 21, a escola ultrapassa a dimensão do desempenho acadêmico proveniente da acumulação de conteúdos, na direção de um conhecimento mobilizador que exige uma posição protagonista do estudante, isto é, uma possibilidade de saber e fazer. Essa configuração requer um currículo referenciado em competências e, todavia, as competências cognitivas, por si só, não são suficientes para formar esse estudante capaz de enfrentar os desafios do século 21, daí a emergência de uma Educação Integral que vise o desenvolvimento pleno, por meio de competências cognitivas e socioemocionais. O reconhecimento dos prejuízos da fragmentação do conhecimento e da supervalorização da dimensão racional revelou, no campo educacional, a necessidade de ações de integração curricular e de abordagens que promovam o desenvolvimento pleno - cognitivo e socioemocional, mediado pelo uso das tecnologias digitais. A formação de professores com estas competências na perspectiva Construcionista, Contextualizada e Significativa (CCS) é o foco deste artigo, que une a expertise do Instituto Ayrton Senna (IAS) na formação integral com a da equipe da Universidade Estadual Paulista (Unesp), que desenvolve pesquisa relacionadas a formação segundo esta abordagem.
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Gásperi, Audir C., Ariano M. Prestes, and Leila M. Costamilan. "Reação de cultivares de soja à podridão vermelha da raiz causada por Fusarium solani f. sp. glycines." Fitopatologia Brasileira 28, no. 5 (October 2003): 544–47. http://dx.doi.org/10.1590/s0100-41582003000500013.
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A podridão vermelha da raiz, causada por Fusarium solani f. sp. glycines, é considerada uma das doenças mais severas de soja (Glycine max) no Sul do Brasil. Este trabalho avaliou a reação de 30 genótipos de soja em experimentos conduzidos em câmara de crescimento, na Embrapa Trigo, Passo Fundo, RS. Inoculou-se o fungo nos genótipos pelo método "palito-de-dente", através da introdução de uma ponta de palito colonizada pelo fungo no hipocótilo de cada plântula e pelo método "grão de sorgo", em que o inóculo, constituído de grãos de sorgo (Sorghum bicolor) colonizados, foi colocado ao redor do colo da planta. Avaliaram-se os sintomas na parte aérea e no sistema radicular. Para ambos métodos de inoculação, houve diferenças entre genótipos e a amplitude de reação variou de resistência moderada à alta suscetibilidade. Os genótipos BRS 66, BRS 137 e BRS 138, pelo método "palito-de-dente", e IAS 5 e BRS 137, pelo método "grão de sorgo", foram considerados moderadamente resistentes. Os genótipos Embrapa 59, CEP 12-Cambará, Ipagro 21, FT-Guaíra, FT-Abyara, BR-4 e FT-2003 foram moderadamente suscetíveis (MS) pelo método "palito-de-dente", enquanto Ivorá, RS 7-Jacuí, Fepagro RS-10, BR-16, CD 203, BR-4, CEP 20-Guajuvira, BRS 154, BRS 138 e Cobb foram MS pelo método "grão de sorgo". Por outro lado, Bragg, CD 205, RS 5-Esmeralda, RS 9- Itaúba, IAS 4, Ocepar 14, CD 201, FT 2011, FT-Saray, BRS 153 e FT-2004 foram suscetíveis em ambos os métodos usados.
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Rice, Hal, Mario Martínez Galdámez, Markus Holtmannspötter, Laurent Spelle, Konstantinos Lagios, Maria Ruggiero, Pedro Vega, Hemant Sonwalkar, René Chapot, and Saleh Lamin. "Periprocedural to 1-year safety and efficacy outcomes with the Pipeline Embolization Device with Shield technology for intracranial aneurysms: a prospective, post-market, multi-center study." Journal of NeuroInterventional Surgery 12, no. 11 (June 1, 2020): 1107–12. http://dx.doi.org/10.1136/neurintsurg-2020-015943.
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BackgroundThe first and second generations of the Pipeline Embolization Device (PED) have been widely adopted for the treatment of intracranial aneurysms (IAs) due to their high associated occlusion rates and low morbidity and mortality. The objective of this study was to evaluate the safety and effectiveness of the third- generation Pipeline Shield device (PED-Shield) for the treatment of IAs.MethodsThe SHIELD study was a prospective, single-arm, multicenter, post-market, observational study evaluating the PED-Shield device for the treatment of IAs. The primary efficacy endpoint was complete aneurysm occlusion without significant parent artery stenosis or retreatment at 1-year post-procedure and the primary safety endpoint was major stroke in the territory supplied by the treated artery or neurological death.ResultsOf 205 subjects who consented across 21 sites, 204 subjects with 204 target aneurysms were ultimately treated (mean age 54.8±12.81 years, 81.4% [166/204] female). Technical success (ie, deployment of the PED-Shield) was achieved in 98.0% (200/204) of subjects with a mean number of 1.1±0.34 devices per subject and a single device used in 86.8% (177/204) of subjects. The primary effectiveness endpoint was met in 71.7% (143/200) of subjects while the primary safety endpoint occurred in six (2.9%) subjects, two (1.0%) of which led to neurological death.ConclusionsThe findings of the SHIELD study support the safety and effectiveness of the PED-Shield for IA treatment, evidenced by high occlusion rates and low rates of neurological complications in the study population.Clinical trial registration-URLhttp://www.clinicaltrials.gov. Unique identifier: NCT02719522.
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Abey, Nosarieme Omoregie, and Osaretin Albert Taiwo Ebuehi. "Semen Analysis and Morphological Study of Two Subsequent Generations of Dietary Protein Deficient Sprague Dawley Rats." International Annals of Science 10, no. 1 (October 22, 2020): 85–91. http://dx.doi.org/10.21467/ias.10.1.85-91.
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Adequate supply of dietary protein in regular diet is an important element of a proper nutritional status as it functions in the regulation of metabolic profiles signaling the reproductive axis. Reports have highlighted the association of the amount of protein in the diet to the functioning of hypothalamic-pituitary-testis axis, however its intragenerational effects are yet to be adequately explored. The study aims to analyze the effect of protein deficient diet on parameters associated with male infertility from one generation to another. Female rats in four (4) groups (n=10) were fed different ration of protein in their diet (PD) as formulated: 21% PD, 10%PD, 5%PD and control diet (rat chow), through gestation and lactation to first and second generations, while the male offspring sustained on the maternal diet after weaning were used for analysis. Sperm morphology and motility were evaluated using a light microscope and a computer-assisted semen analysis. The percentage of motile spermatozoa, morphological characteristics and histology in the deficient groups (5%, 10%PD) appeared normal as compared to control in the first generation, showing an adaptive response while second generation was presented with significantly altered fertility parameters of the male offspring. It is suggested that in a deficiency status especially at the critical phase of development, certain deleterious effects which may be adaptive or phenotypic can serve to reduce the fertility efficiency in the male offspring at both F1 and F2- generation.
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Muntean, Iolanda, Daniela Toma, and Rodica Togănel. "Predictors of Inadequate Mixing in Transposition of the Great Arteries — a Critical Neonatal Condition." Journal Of Cardiovascular Emergencies 3, no. 4 (December 1, 2017): 181–87. http://dx.doi.org/10.1515/jce-2017-0024.
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Abstract Background: Simple transposition of the great arteries (TGA) is a cyanotic critical congenital heart defect representing a neonatal cardiovascular emergency, which requires surgery early after birth. In case of inadequate mixing between systemic and pulmonary circulations, creating an unrestrictive interatrial communication is mandatory. The aim of the present study was to identify the most important echocardiographic parameters that can predict the need for balloon atrial septostomy (BSA) in TGA neonates. Material and methods: We retrospectively reviewed the echocardiographic recordings of newborns with TGA referred to our emergency room during a 6-year period. We measured the following echocardiographic parameters: atrial septal defect (ASD) size, interatrial septum (IAS) length, peak/mean inter-atrial pressure gradient, transverse diameter of the left atrium (LA), and transverse diameter of the right atrium (RA). Also, the ratio between ASD/IAS, the ratio between LA/RA, the ratio between mitral/tricuspid annulus, the ASD peak gradient/ASD diameter and the ASD diameter/(LA:RA ratio) were calculated. Results: There were 37 neonates with simple TGA presented to the emergency room, split into two groups: those with BAS (n = 21) and those without BAS (n = 16). Besides significant differences between the two groups in ASD size, peak/mean interatrial pressure gradient, and LA:RA ratio, we found that ASD peak gradient/ASD diameter was significantly higher, but ASD diameter/(LA:RA ratio) was significantly lower in the group that required BAS compared with the group without BAS. Multivariate analysis showed that ASD diameter/(LA:RA ratio) was an independent predictor of septostomy requirement, with a cut-off value of 2.58. Conclusion: ASD diameter/(LA/RA ratio) is a useful echocardiographic parameter that can provide supplementary information regarding inadequate mixing and the need for BAS in neonates with TGA.
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Shortland, Susan, and Stephen J. Perkins. "Long-term assignment reward (dis)satisfaction outcomes: hearing women’s voices." Journal of Global Mobility 4, no. 2 (June 13, 2016): 225–50. http://dx.doi.org/10.1108/jgm-04-2015-0011.
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Purpose – Drawing upon compensating differentials, equity theory, and the psychological contract, women’s voices illustrate how organisational policy dissemination, implementation and change can lead to unintended assignee dissatisfaction with reward. Implications arise for organisational justice which can affect women’s future expatriation decisions. The paper aims to discuss these issues. Design/methodology/approach – A qualitative case study methodology was employed. Reward policies for long-term international assignments (IAs) were analysed. In-depth semi-structured interviews were conducted confidentially with 21 female long-term assignees selected using stratified sampling, and with two managers responsible for international reward policy design/implementation. Findings – Policy transparency is required. Women perceive inequity when allowances based on grade are distorted by family status. Women in dual career/co-working couples expect reward to reflect their expatriate status. Reward inequity is reported linked to specific home/host country transfers. Policy change reducing housing and children’s education are major causes of reward dissatisfaction. Research limitations/implications – This case study research was cross-sectional and set within one industry. It addressed reward outcomes only for long-term IAs from the perspectives of women who had accepted expatriation in two oil and gas firms. Practical implications – Reward policy should be transparent. Practitioners might consider the inter-relationship between policy elements depending on grade and accompanied status, location pairings, and the effects of policy content delivery to dual career/co-working couples. Originality/value – This paper advances the field of IA reward by examining compensating differentials, equity and the psychological contract and takes these forward via implications for organisational justice. It identifies reward elements that support women’s expatriation and address their low share of expatriate roles, thereby fostering gender diversity. Future research themes are presented.
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Franco, José Rodrigo Galli, Alice Eiko Murakami, Cristiane Regina do Amaral Duarte, Jovanir Inês Müller Fernandes, Elis Regina de Moraes Garcia, and Ivan Moreira. "Intervalo para o alojamento e níveis de lisina, em dietas baseadas no conceito de proteína ideal, sobre o desenvolvimento muscular e rendimento de carcaça de frangos de corte." Ciência Rural 42, no. 9 (July 31, 2012): 1655–61. http://dx.doi.org/10.1590/s0103-84782012005000063.
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Este trabalho objetivou estudar os efeitos do intervalo para o alojamento (IA) e de níveis de lisina digestível (LD) nas dietas iniciais sobre o desenvolvimento do músculo do peito e rendimento de carcaça de frangos de corte. Para tanto, 1.760 pintos de corte, machos, Cobb500, foram distribuídos aleatoriamente em oito grupos experimentais em arranjo fatorial 2x4 de 4 IAs (12, 24, 36 e 48h) e dois níveis de LD (1,143 e 1,267%), com quatro repetições e 55 aves por unidade experimental. Met+Cys, Thr e Trp foram balanceados no conceito de proteína ideal. Não houve interação significativa entre LD e IA sobre as variáveis avaliadas. Os maiores pesos do peito desossado e filé de peito aos 21 dias de idade e peso corporal aos 43 dias foram obtidos no nível de 1,143% de LD. O peso do peito desossado, peso do filé, diâmetro das fibras musculares aos 21 dias, peso vivo, peso da carcaça e peso das pernas aos 43 dias de idade decresceram linearmente de acordo com o aumento no intervalo para alojamento. Os resultados deste estudo sugerem que o nível de 1,143% de LD favorece aumento no músculo peitoral aos 21dias e o peso vivo dos frangos aos 43 dias, e que o menor intervalo para o alojamento melhora o desenvolvimento dos músculos peitorais durante a fase inicial, e maior rendimento da carcaça inteira e das pernas no abate.
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Stanley, Herbert Okechukwu, and Ekoh Philip Efua. "Impact of Effective Microorganisms on the Microbiological and Physicochemical Parameters of Produced Water." International Annals of Science 3, no. 1 (November 17, 2017): 6–12. http://dx.doi.org/10.21467/ias.3.1.6-12.
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The study investigated the impact of effective microorganisms on the microbiological and physicochemical parameters of produced water. Produced water was obtained from Ebocha oil field within Rivers state. The spread plate method was used to determine the total heterotrophic bacterial counts, and pure isolates were subjected to biochemical characterization. Pure bacterial suspension of Lactobacillus plantarum, Aspergillus sp. and Penicillium italicum were obtained and subsequently inoculated into wastewater sample in consortium. Treated (with the consortium) wastewater sample was analyzed at interval for their physicochemical and microbiological parameters during the appropriate period of incubation (14 days) at room temperature. The bacterial load of produced water decreased from 1.3 x 108 cfu/ml to 3.6 x 107 cfu/ml, coliform counts increased from 2.0 x 105 cfu/ml to 1.4 x 106 cfu/ml, Staphylococcal counts decreased from 3.4 x 105 cfu/ml to 0 cfu/ml and Vibrio counts decreased from 8.0 x 105 cfu/ml to 2.0 x 105 cfu/ml. Biochemical characterization of bacterial isolates from the wastewater revealed the presence of Enterobacter sp, Bacillus sp, Klebsiella sp, Proteus sp, Escherichia coli and Staphylococcus sp. The pH and temperature ranges of water sample during the period of treatment varied. The BOD values decreased from 240 mg/L to 21 mg/L while the COD values decreased from 400 mg/L to 160 mg/L. The results of the heavy metal assessment revealed an appreciable reduction in the heavy metal concentrations of the sample. The concentration of zinc in produced water decreased from 0.113 mg/L to an undetectable level (< 0.01 mg/L), iron concentration decreased from 1.071 mg/L to 0.139 mg/L, Nickel decreased from 2.110 mg/L to 1.081 mg/L while copper and cadmium were undetected. The use of effective microorganisms in the treatment of produced water was effective in the reduction of microbial load, biochemical oxygen demand (BOD), chemical oxygen demand (COD) and removal of heavy metals.
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Kumar, Ashok, and Sambhunath Das. "Intraoperative Echocardiographic Detection of Septal Aneurysm and Additional Ventricular Septal Defect in a Child with Tetralogy of Fallot." Journal of Perioperative Echocardiography 5, no. 1 (2017): 21–24. http://dx.doi.org/10.5005/jp-journals-10034-1064.
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ABSTRACT A 2-year-old child was diagnosed with subaortic ventricular septal defect (VSD) with severe infundibular and valvular pulmonary stenosis (PS) by transthoracic echocardiography. Intraoperative transesophageal echocardiography (TEE) detected aneurysmal interventricular and interatrial septum (IAS), subaortic VSD, and right ventricular outflow tract (RVOT) with an additional midmuscular VSD. The aneurysmal interventricular septum (IVS) was repaired. An accessory tricuspid papillary muscle was attached to RVOT, which was augmented with a transannular pericardial patch to have minimal postoperative gradient without sacrificing the accessory papillary muscle (APM). This rare case poses a challenge to the anesthetist and surgeon in the form of diagnostic differences, severe right ventricle (RV) dysfunction with aneurysmal IVS, and difficulty in reconstruction of RVOT. Intraoperative TEE played a greater role to diagnose the IVS aneurysm, additional VSD and guide for appropriate surgery. How to cite this article Das S, Kumar A. Intraoperative Echocardiographic Detection of Septal Aneurysm and Additional Ventricular Septal Defect in a Child with Tetralogy of Fallot. J Perioper Echocardiogr 2017;5(1):21-24.
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Raicheva, E., Т. Ivanova, E. Kipriotis, and E. Kistanova. "The characteristic of control day milk and its properties in ewes from different breeds in Bulgaria." Biotehnologija u stocarstvu 23, no. 5-6-2 (2007): 139–44. http://dx.doi.org/10.2298/bah0702139r.
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The aim was the investigation the milk and its composition for control day in local sheep breeds. The experiment was carried out with 19 Karakachan ewes and 21 West Balkan Mountain ewes from the flock of IAS-Kostinbrod and 15 Local Sofia ewes from a private flock from village Klisura. The study is a part of Bulgarian-Greece project for research of F1- crosses of Chios breed. The experimental ewes were mothers of F1 Chios? crosses. The milk for day was recorded on first control during milking period. The content of milk - fats, proteins, non fat solid, dry matter and density were estimated by individual milk samples by analyzer "Ekomilk". The average milk yield for control day of ewes from Karakachan, West Balkan Mountain and Local Sofia breeds was 0,344 l, 0,421 l and 0,633 l respectively. The content of fat, protein and total solids in milk of Karakachan ewes was - 5,91%, 5,19% and 16,42% respectively, of West Balkan Mountain ewes - 6,41%, 5,10% and 16,67% and of Sofia local ewes - 6,35%, 5,94% and 17,57%.
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Nevzati, Edin, Jeannine Rey, Daniel Coluccia, Basil Erwin Grüter, Stefan Wanderer, Michael vonGunten, Luca Remonda, et al. "Aneurysm wall cellularity affects healing after coil embolization: assessment in a rat saccular aneurysm model." Journal of NeuroInterventional Surgery 12, no. 6 (December 23, 2019): 621–25. http://dx.doi.org/10.1136/neurintsurg-2019-015335.
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Background and purposeDespite significant technical advances, recanalization rates after endovascular therapy of ruptured intracranial aneurysms (IAs) remain a clinical challenge. A histopathological hallmark of ruptured human IA walls is mural cell loss. Mural smooth muscle cells (SMCs) are known to promote intraluminal healing in thrombosed experimental aneurysms. In this rat model we assess the natural history and healing process after coil embolization in SMC-rich and decellularized aneurysms.MethodsSaccular aneurysms were created by end-to-side anastomosis of an arterial graft from the descending thoracic aorta of a syngeneic donor rat to the infrarenal abdominal aorta of recipient male Wistar rats. Untreated arterial grafts were immediately transplanted, whereas aneurysms with loss of mural cells were chemically decellularized before implantation. Aneurysms underwent coil implantation during aneurysm anastomosis. Animals were randomly assigned either to the non-decellularized or decellularized group and underwent macroscopic and histological analyses on days 3, 7, 21, or 90 post-coil implantation.ResultsA total of 55 rats underwent macroscopic and histologic analysis. After coil embolization, aneurysms with SMC-rich walls showed a linear course of thrombosis and neointima formation whereas decellularized aneurysms showed marked inflammatory wall degeneration with increased recanalization rates 21 days (p=0.002) and 90 days (p=0.037) later. The SMCs showed the ability to actively migrate into the intra-aneurysmal thrombus and participate in thrombus organization.ConclusionsCoil embolization of aneurysms with highly degenerated walls is prone to further wall degeneration, increased inflammation, and recanalization compared with aneurysms with vital SMC-rich walls.
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MENOSSO, ORIVAL GASTÃO, JOSÉ ANTONIO COSTA, IBANOR ANGHINONI, and HUMBERTO BOHNEN. "Tolerância de genótipos de soja ao alumínio em solução." Pesquisa Agropecuária Brasileira 35, no. 11 (November 2000): 2157–66. http://dx.doi.org/10.1590/s0100-204x2000001100006.
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O conhecimento da reação dos genótipos de soja (Glycine max L.) ao alumínio (Al), existente em solos ácidos, é indispensável para sua utilização em programas de melhoramento. Foram desenvolvidos, inicialmente, ensaios com o objetivo de identificar os níveis de Al e cálcio (Ca) em soluções diluídas, e da melhor época para a medição dos parâmetros do sistema radicular para a separação dos genótipos de soja em relação à tolerância ao Al. Numa etapa seguinte, os ensaios objetivaram avaliar a tolerância ao Al de cultivares de soja brasileiras, de linhagens de interesse para o melhoramento, e de cultivares-padrões norte-americanas ao Al. Foi utilizado o nível de 0,2 mg L-1 de Al em solução com 50 mg L-1 de Ca e determinado o incremento no comprimento da raiz primária até o nono dia. Dos 148 genótipos de soja testados, 21 foram tolerantes ao Al: Biloxi, Bragg, BRAS851736, BRAS863672, BR13 (Maravilha), BR37, Cobb, EMGOPA302, EMGOPA304 (Campeira), FT1, FT5 (Formosa), FT6 (Veneza), FTGuaíra, FTManacá, IAS 4, IPAGRO21, Ivaí, MSBR17 (São Gabriel), OCEPAR 6, Planalto e Tiaraju. Os genótipos agrupados como de tolerância intermediária foram em número de 73, e os sensíveis foram em número de 54.
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Vannemreddy, Prasad, Gloria Caldito, Brian Willis, and Anil Nanda. "Influence of cocaine on ruptured intracranial aneurysms: a case control study of poor prognostic indicators." Journal of Neurosurgery 108, no. 3 (March 2008): 470–76. http://dx.doi.org/10.3171/jns/2008/108/3/0470.
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Object The purpose of this study was to determine whether cocaine use is a significant prognostic factor for outcome measures such as Hunt and Hess grade and Glasgow Outcome Scale (GOS) score among patients presenting with ruptured intracranial aneurysms (IAs). Methods The authors performed a MEDLINE/PubMed search for cases of ruptured IAs associated with cocaine use. Fourteen cases from the authors' experience were combined with 50 from a literature review, for a total of 64 cases associated with cocaine use. These 64 cases were compared with 65 cases without cocaine use (controls), which had been obtained from an aneurysm database. Logistic regression analysis was performed to determine significant prognostic factors for a poor Hunt and Hess grade and a poor GOS score, and a general linear model was applied to identify significant factors for these measures among cocaine users. Results There were 40 women in each group. The mean age was 32.3 ± 8.1 years in the cocaine group and 49.7 ± 10.6 years in the control group; thus, patients in the cocaine group were significantly younger (p < 0.01). Cocaine was snorted in 21% of cases, smoked in 55%, and intravenously injected or taken in through a combination of routes in 24%. Fifty-one percent of cocaine users and 7.7% of nonusers presented with a poor GOS score (p < 0.01). Fifty-six percent had ictus during cocaine abuse. At the end of a 30-day follow-up, 51% of the patients in the cocaine group had a good GOS score compared with 92% in the control group (p < 0.01). Controlling for the effects of other significant factors, cocaine use had a significant effect on Hunt and Hess grade (p < 0.03) and GOS score (p < 0.01). The odds of having a poor Hunt and Hess grade among cocaine users were 4.2 times greater than those in nonusers, and the odds of having a poor GOS score among cocaine users were 38.8 times greater. Conclusions Aneurysms were significantly smaller and ruptured at a younger age among cocaine users compared with nonusers. Although the poor clinical grade was not significantly different between the 2 groups, outcome was significantly worse in cocaine users.
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Garrana, Rhoodie, Govindrau Mohangi, Paulo Malo, and Miguel Nobre. "Leakage of Microbial Endotoxin through the Implant-Abutment Interface in Oral Implants: An In Vitro Study." BioMed Research International 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/9219071.
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Background. Endotoxin initiates osteoclastic activity resulting in bone loss. Endotoxin leakage through implant abutment connections negatively influences peri-implant bone levels.Objectives. (i) To determine if endotoxin can traverse different implant-abutment connection (IAC) designs; (ii) to quantify the amount of endotoxins traversing the IAC; (iii) to compare the in vitro comportments of different IACs.Materials and Methods. Twenty-seven IACs were inoculated withE. coliendotoxin. Six of the twenty-seven IACs were external connections from one system (Southern Implants) and the remaining twenty-one IACs were made up of seven internal IAC types from four different implant companies (Straumann, Ankylos, and Neodent, Southern Implants).Results. Of the 27 IACs tested, all 6 external IACs leaked measurable amounts of endotoxin. Of the remaining 21 internal IACs, 9 IACs did not show measurable leakage whilst the remaining 12 IACs leaked varying amounts. The mean log endotoxin level was significantly higher for the external compared to internal types (p=0.015).Conclusion. Within the parameters of this study, we can conclude that endotoxin leakage is dependent on the design of the IAC. Straumann Synocta, Straumann Cross-fit, and Ankylos displayed the best performances of all IACs tested with undetectable leakage after 7 days. Each of these IACs incorporated a morse-like component in their design. Speculation still exists over the impact of IAC endotoxin leakage on peri-implant tissues in vivo; hence, further investigations are required to further explore this.
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Vergara Medrano, Segundo E., Jorge Torres Delgado, Flor Teresa García, Freddy Peláez Peláez, and Narda Alarcon R. "Riqueza de taxa principales en el bosque del Centro de Investigación y Producción "Pablo Yacu" Universidad Nacional de San Martín -Tarapoto." APORTE SANTIAGUINO 3, no. 1 (July 19, 2010): 67. http://dx.doi.org/10.32911/as.2010.v3.n1.423.
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Se determinó la riqueza de Pteridoflora. Avifauna y Orquídeo-flora del bosque del Centro de Producción e Investigación "Pablo Yacu" de la Facultad de Ecología de la UNSM-T. El área tiene una extensión ele 200 Has., y se ubica entre los 870 y 1700 msnm. Las observaciones se realizaron en octubre del 2008 y marzo del 2009. Para la identificación de helechos, se utilizó claves taxonómicas de Tryon y Stolze ( 1989a, 1989b, 1991. 1992, 1993, 1994 ), se comparó con muestras del Herbarium T ruxi II ience y registros fotográficos. Respecto a la avifauna se utilizó la técnica de presencia/ausencia en horarios matutino y vespertino considerando el hábitat/micro-hábitat. Para las orquídeas, el muestreo se realizó mediante transectos perpendiculares al del Pteridofitos, con determinaciones "in situ" complementadas con bibliografía especifica.<br />El registro fotográfico fue ele las que estuvieron en floración. La riqueza de pteridofitos es de 136 ( 44 géneros y 21 fami I ias). de avifauna fue ele 278 especies: 202 géneros y 40 familias con tres especies endémicas y las orquídeas presentan 45 especies distribuidas en 34 géneros. Finalmente, se concluye que se podría iniciar actividades y acciones para realizar una base ele datos que contribuya a la implementación ele la estrategia ele diversidad biológica de la región San Martín.
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Paliwal, Nikhil, Prakhar Jaiswal, Vincent M. Tutino, Hussain Shallwani, Jason M. Davies, Adnan H. Siddiqui, Rahul Rai, and Hui Meng. "Outcome prediction of intracranial aneurysm treatment by flow diverters using machine learning." Neurosurgical Focus 45, no. 5 (November 2018): E7. http://dx.doi.org/10.3171/2018.8.focus18332.
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OBJECTIVEFlow diverters (FDs) are designed to occlude intracranial aneurysms (IAs) while preserving flow to essential arteries. Incomplete occlusion exposes patients to risks of thromboembolic complications and rupture. A priori assessment of FD treatment outcome could enable treatment optimization leading to better outcomes. To that end, the authors applied image-based computational analysis to clinically FD-treated aneurysms to extract information regarding morphology, pre- and post-treatment hemodynamics, and FD-device characteristics and then used these parameters to train machine learning algorithms to predict 6-month clinical outcomes after FD treatment.METHODSData were retrospectively collected for 84 FD-treated sidewall aneurysms in 80 patients. Based on 6-month angiographic outcomes, IAs were classified as occluded (n = 63) or residual (incomplete occlusion, n = 21). For each case, the authors modeled FD deployment using a fast virtual stenting algorithm and hemodynamics using image-based computational fluid dynamics. Sixteen morphological, hemodynamic, and FD-based parameters were calculated for each aneurysm. Aneurysms were randomly assigned to a training or testing cohort in approximately a 3:1 ratio. The Student t-test and Mann-Whitney U-test were performed on data from the training cohort to identify significant parameters distinguishing the occluded from residual groups. Predictive models were trained using 4 types of supervised machine learning algorithms: logistic regression (LR), support vector machine (SVM; linear and Gaussian kernels), K-nearest neighbor, and neural network (NN). In the testing cohort, the authors compared outcome prediction by each model trained using all parameters versus only the significant parameters.RESULTSThe training cohort (n = 64) consisted of 48 occluded and 16 residual aneurysms and the testing cohort (n = 20) consisted of 15 occluded and 5 residual aneurysms. Significance tests yielded 2 morphological (ostium ratio and neck ratio) and 3 hemodynamic (pre-treatment inflow rate, post-treatment inflow rate, and post-treatment aneurysm averaged velocity) discriminants between the occluded (good-outcome) and the residual (bad-outcome) group. In both training and testing, all the models trained using all 16 parameters performed better than all the models trained using only the 5 significant parameters. Among the all-parameter models, NN (AUC = 0.967) performed the best during training, followed by LR and linear SVM (AUC = 0.941 and 0.914, respectively). During testing, NN and Gaussian-SVM models had the highest accuracy (90%) in predicting occlusion outcome.CONCLUSIONSNN and Gaussian-SVM models incorporating all 16 morphological, hemodynamic, and FD-related parameters predicted 6-month occlusion outcome of FD treatment with 90% accuracy. More robust models using the computational workflow and machine learning could be trained on larger patient databases toward clinical use in patient-specific treatment planning and optimization.
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Richards, RA. "A tiller inhibitor gene in wheat and its effect on plant growth." Australian Journal of Agricultural Research 39, no. 5 (1988): 749. http://dx.doi.org/10.1071/ar9880749.
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A recessive gene that inhibits tillering was identified in a wheat (Triticum aestivum L.) from Israel. The locus for tiller inhibition, designated Tin, is linked to the locus for hairy glume (10 � 3 map units apart) and black awns, and hence is presumed to be on the distal end of chromosome IAS. Such a gene has been proposed as desirable for wheat in both low and high input environments. Serial sowings were made every 21 days between autumn and spring in buckets outdoors with lines differing in tillering. At a harvest at the 4.5 leaf stage, tillering was less in the low tillering lines than in the conventional lines in all sowings, but leaf area and weight per plant were unexpectedly higher. Stunting, which is a characteristic of low tillering lines when temperatures are low and daylength long, became apparent in one of the low tillering lines in sowings made in late winter and spring at a time when daylength was 11.5 h and increasing. In four populations segregating for the tillering trait, low tiller number was associated with a higher harvest index, reduced height, an increased duration of the flag leaf life and of grain filling, a lower leaf to stem weight ratio at maturity, higher specific leaf weight, higher stem density and a higher kernel number per unit stem weight. Traits likely to severely limit crop yield other than stunting were not found.
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Kushnir, Mark M., Tord Naessen, Dmitrijus Kirilovas, Andrey Chaika, Jelena Nosenko, Iryna Mogilevkina, Alan L. Rockwood, Kjell Carlström, and Jonas Bergquist. "Steroid Profiles in Ovarian Follicular Fluid from Regularly Menstruating Women and Women after Ovarian Stimulation." Clinical Chemistry 55, no. 3 (March 1, 2009): 519–26. http://dx.doi.org/10.1373/clinchem.2008.110262.
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Abstract Background: Information on the concentrations of steroids in ovarian follicular fluid (FF) from regularly menstruating (RM) women has been limited because of the absence of methods for the simultaneous quantification of multiple steroids in small volumes of FF. We studied steroid profiles in FF during the early follicular phase of the menstrual cycle and after ovarian stimulation for in vitro fertilization (IVF), and compared concentrations with published values obtained by immunoassay (IA). Methods: We used liquid chromatography–tandem mass spectrometry (LC-MS/MS) to measure 13 steroids in 40-μL aliquots of FF samples from 21 RM women and from 5 women after ovarian stimulation for IVF. Relationships between concentrations of steroids and their ratios (representations of the enzyme activities) were evaluated within and between subgroups. Results: The concentrations of testosterone (Te), androstenedione (A4), and estradiol (E2) measured by LC-MS/MS were lower than those previously reported in studies with IAs. In RM women, androgens were the most abundant class of steroids, with A4 being the major constituent. The concentrations of 17-hydroxyprogesterone (17OHP), total androgens, and estrogens were 200- to 1000-fold greater in FF than in serum. Compared with RM women, FF samples from women undergoing ovarian stimulation had significantly higher concentrations of E2 (P = 0.021), pregnenolone (P = 0.0022), 17OHP (P = 0.0007), and cortisol (F) (P = 0.0016), and significantly higher ratios of F to cortisone (P = 0.0006), E2 to estrone (P = 0.0008), and E2 to Te (P = 0.0013). Conclusions: The data provide the first MS-based concentration values for 13 steroids in ovarian FF from RM women, from estrogen- and androgen-dominant follicles, and from women after ovarian stimulation for IVF.
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Hornby, L., A. L. Coates, and L. C. Lands. "Effect of analyzer on determination of mixed venous PCO2 and cardiac output during exercise." Journal of Applied Physiology 79, no. 3 (September 1, 1995): 1032–38. http://dx.doi.org/10.1152/jappl.1995.79.3.1032.
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Cardiac output (CO) during exercise can be determined noninvasively by using the indirect Fick CO2-rebreathing technique. CO2 measurements for this technique are usually performed with an infrared analyzer (IA) or mass spectrometer (MS). However, IA CO2 measurements are susceptible to underreading in the face of high O2 concentrations because of collision broadening. We compared an IA (Ametek model CD-3A) with a MS (Marquette model MGA-1100) to see the effect this would have on mixed venous PCO2 (PVCO2) and CO measurements. After calibration with room air and a gas mixture of 5% CO2–12% O2–83% N2, both devices were tested with three different gas mixtures of CO2 in O2. For each gas mixture, IA gave lower CO2 values than did the MS (4.1% CO2: IA, 3.85 +/- 0.01% and MS, 4.13 +/- 0.01%; 9.2% CO2: IA, 8.44 +/- 0.07% and MS, 9.19 +/- 0.01%; 13.8% CO2: IA, 12.57 +/- 0.15% and MS, 13.82 +/- 0.01%). Warming and humidifying the gases did not alter the results. The IA gave lower values than did the MS for eight other medical gases in lower concentrations of O2 (40–50%). Equilibrium and exponential rebreathing procedures were performed. Values determined by the IA were > 10% higher than those determined by the MS for both rebreathing methods. We conclude that all IAs must be checked for collision broadening if they are to be used in environments where the concentration of O2 is > 21%. If collision broadening is present, then either a special high O2-CO2 calibration curve must be constructed, or the IA should not be used for both arterial PCO2 and PVCO2 estimates because it may produce erroneously low PVCO2 values, with resultant overestimation of CO.
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Edelman, Martin J., Josephine Louella Feliciano, Miroslav Styblo, Tao Liu, Rena G. Lapidus, Jesse Saunders, and Joga Gobburu. "Phase I and pharmacokinetic trial of the antitemolerase agent KML001 (KML) and cisplatin (CDDP) in advanced solid tumors." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 2515. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.2515.
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2515 Background: Telomerase is overexpressed in most solid tumors and rarely expressed in adult tissues and is therefore a promising target. We have previously demonstrated that KML001 (sodium metaarsenite) displaces hTERT from the nucleus and is cytotoxic (Clin Cancer Res 14:4593-602, 2008). We have also demonstrated that it is synergistic with cisplatin. Methods: Pts with advanced solid tumors, PS 0-1, normal renal and hepatic function were eligible. Treatment was with CDDP 75 mg/m2 day 1 and KML p.o. daily days 1-14 on a 21 day cycle. It was planned that KML doses would be escalated by 2.5 mg beginning at 15 mg/day. A 3+3 design was employed. Blood specimens for arsenic and platinum pk were obtained at hours 0,1,2,3,4,5,6, 24 and day 15 and 22. Tumor blocks were required to assess for telomerase expression. Results: 18 patients (7M,11F) are evaluable for toxicity. Pts were heavily pretreated (median number of prior regimens =3). 16 had prior platinum therapy. The dose limiting toxicity was QTc interval prolongation seen in three patients in cohort 3 (20 mg) (two during cycle 1, one during cycle 2). A PR was seen in a patient with heavily pretreated SCLC in cohort 1. 1 other pt with SCLC and 2 with NSCLC also experienced reduction in disease burden. 10/18 pts received >3 cycles of therapy. Other common toxicities observed were nausea, vomiting and cytopenias. Significant, but not dose limiting, neutropenia or thrombocytopenia (> grade 3) was observed in cohorts 1 and 2. Myelosuppression was primarily seen in pts with prior radiotherapy. Non-compartmental analysis for inorganic arsenic (iAs) and the mono (MAs) and dimethylarsenic (DMAs) metabolites was performed (Table). Conclusions: 1. The combination of KML-001 and CDDP is feasible and active. 2. We are currently evaluating CDDP 75 mg/m2 and KML 17.5 mg in an expansion cohorts of advanced SCLC and NSCLC. 3. Studies of telomerase expression are in progress. (R21CA130349-01) Clinical trial information: NCT01110226. [Table: see text]
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Łazarowicz, Edyta. "Evaluation of information in the statements of profit or loss and other comprehensive income of WIG30 companies." Zeszyty Teoretyczne Rachunkowości 2018, no. 97 (153) (May 10, 2018): 77–98. http://dx.doi.org/10.5604/01.3001.0012.0377.
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The aim of the article is to analyze and assess the comparability of the structure and content of statements of profit or loss and other comprehensive income of listed companies included in the WIG30 index (excluding financial institutions and foreign companies) and to propose some solutions to increase comparability. 21 financial statements for 2016 were analyzed. Two research methods were used: literature review and anal-ysis of the content of financial statements. All companies presented gross profit subtotal, which classified expenses by function in the statement of profit or loss and other comprehensive income (almost 75% of analyzed companies). However, some differences were observed in the calculation of that subtotal. The majority of the companies also presented other subtotals which are not required by IAS 1 – an operating profit subtotal and profit before tax subtotal. Generally all companies classified expenses by nature in the manner prescribed in the Polish Accounting Act. IASB should consider a requirement that companies pre-sent more additional subtotals in the statement of profit or loss and other comprehensive income, and should also prescribe the way of its calculation because many companies in the world (including Poland) present such subtotals. Moreover, in order to increase comparability of this statement, it might be advisable to introduce more detailed regulations concerning classification of expenses by nature and the place of presen-tation of the item Share of result of associates and joint ventures, because as some research indicates there are inconsistencies at the global scale. The findings of this research can be useful for the IASB work on changes in the structure and content of the statement of profit or loss and other comprehensive income to increase its comparability. Moreover, in Poland, previous research concerning the structure and content of the statement of profit or loss and other comprehensive income mainly focused on other comprehensive income rather than profit or loss.
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Haghayegh, S., S. Khoshnevis, M. H. Smolensky, K. R. Diller, and R. J. Castriotta. "1196 Machine Learning Derived-Interpretative Algorithm Better Differentiates Sleep and Wake Epochs and Estimates Sleep Parameters from Wrist Actigraphy Data." Sleep 43, Supplement_1 (April 2020): A457—A458. http://dx.doi.org/10.1093/sleep/zsaa056.1190.
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Abstract Introduction Several different interpretive algorithms (IAs) are available for scoring actigraphy-obtained body movement data for sleep and wake epochs. Although most have high sensitivity in detecting sleep epochs, they identify wake epochs poorly. We derived a machine learning (ML) based IA that improves differentiation of sleep and wake epoch to better estimate sleep parameters. Methods Forty-one adults (18 females) 26.6±12.0 years old underwent at-home single-night sleep assessment. Motionlogger® Micro Watch Actigraph recorded in zero crossing mode body movement per 30s epoch, with automated sleep scoring by single-channel electroencephalography (EEG) device (Zmachine® Insight+) as reference. The popular Cole-Kripke IA was applied to score body movement time series data of the following combination of current 1, preceding 4, and following 2 minute long epochs. Data of 21 subjects were utilized to train/derive the ML IA (logistic regression), and data of the other 20 subjects were used to test performance of it and the Cole-Kripke IA. Results In reference to the EEG, the Cole-Kripke actigraphy IA showed sensitivity of 0.98±0.02, specificity of 0.48±0.19, and kappa agreement of 0.53±0.16 in detecting sleep epochs, while the ML-derived IA showed corresponding values of 0.90±0.06, 0.71±0.14, and 0.57±0.11. The Cole-Kripke IA, relative to EEG, method significantly (P<0.05) underestimated sleep onset latency (SOL) by 18.0 min and wake after sleep onset (WASO) by 35.1 min, and overestimated total sleep time (TST) by 53.1 min and sleep efficiency (SE) by 9.6%. The ML-derived IA, relative to EEG significantly underestimated SOL by 15.1 min, but comparably (P>0.05) estimated WASO, TST, and SE. Conclusion The ML-derived IA, in comparison to Cole-Kripke IA, when applied to sleep-time wrist actigraphy data significantly better differentiates wake from sleep epochs and better estimates sleep parameters. Support This work was supported by the Robert and Prudie Leibrock Professorship in Engineering at the University of Texas at Austin.
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CIA, EDIVALDO, IMRE LAJOS GRIDI-PAPP, EDERALDO JOSÉ CHIAVEGATO, NELSON PAULIERI SABINO, JULIO ISAO KONDO, MARIA ANGÉLICA PIZZINATTO, NELSON BORTOLETTO, and LUIZ HENRIQUE CARVALHO. "Melhoramento do algodoeiro no Estado de São Paulo: obtenção da cultivar IAC 21." Bragantia 60, no. 1 (2001): 9–17. http://dx.doi.org/10.1590/s0006-87052001000100002.
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Neste trabalho é relatado o esquema utilizado para obtenção da cultivar IAC 21 realizado durante o período de 1981/82 a 1993/94. A cultivar foi originada por resseleção da IAC 19, direcionada principalmente para resistência a Colletotrichum gossypii var. cephalosporioides e nematóides, através do melhoramento genealógico. No início dos estudos as seleções e respectivas progênies foram comparadas à cultivar original IAC 19 e, posteriormente, a 'IAC 20'. Além das características econômicas de produção e qualidade da fibra, a linhagem foi avaliada para resistência múltipla às doenças: murchas de Fusarium e Verticillium, mancha-angular, ramulose e nematóides. A cultivar IAC 21 foi superior a 'IAC 19' em 6,2%, em produtividade, na média geral dos experimentos, chegando a 18,1% em solos altamente infectados por patógenos; 4,6% em produção de sementes, 2,4% em tenacidade da fibra e 6,9% em tenacidade do fio, sem perdas significativas em outras características, com exceção da porcentagem de fibra que decresceu 2,6%. Com respeito às doenças, apresentou melhores índices para murcha de Fusarium e ramulose mantendo-se, entretanto, no mesmo nível para as demais. Estudos preliminares mostraram que 'IAC 21' apresentou índices inferiores a 'CNPA ITA 90' para a anomalia "murchamento avermelhado". Devido às vantagens verificadas em relação a 'IAC 19' e 'IAC 20', 'IAC 21' foi recomendada para plantio em todas as áreas do Estado de São Paulo, excluindo-se as de ocorrência do "murchamento avermelhado".
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Xiao, Kai, Bo Xu, Lin Ding, Weiguang Yu, Lei Bao, Xinchao Zhang, Meiji Chen, Xiangzhen Liu, Huanyi Lin, and Tengfei Li. "Traditional versus mirror three-dimensional printing technology for isolated acetabular fractures: a retrospective study with a median follow-up of 25 months." Journal of International Medical Research 49, no. 6 (June 2021): 030006052110285. http://dx.doi.org/10.1177/03000605211028554.
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Objective To assess the outcomes of traditional three-dimensional (3D) printing technology (TPT) versus mirror 3D printing technology (MTT) in treating isolated acetabular fractures (IAFs). Methods Consecutive patients with an IAF treated by either TPT or MTT at our tertiary medical centre from 2012 to 2018 were retrospectively reviewed. Follow-up was performed 1, 3, 6, and 12 months postoperatively and annually thereafter. The primary outcome was the Harris hip score (HHS), and the secondary outcomes were major intraoperative variables and key orthopaedic complications. Results One hundred fourteen eligible patients (114 hips) with an IAF (TPT, n = 56; MTT, n = 58) were evaluated. The median follow-up was 25 months (range, 21–28 months). At the last follow-up, the mean HHS was 82.46 ±14.70 for TPT and 86.30 ± 13.26 for MTT with a statistically significant difference. Significant differences were also detected in the major intraoperative variables (operation time, intraoperative blood loss, number of fluoroscopic screenings, and anatomical reduction number) and the major orthopaedic complications (loosening, implant failure, and heterotopic ossification). Conclusion Compared with TPT, MTT tends to produce accurate IAF reduction and may result in better intraoperative variables and a lower rate of major orthopaedic complications.
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ERISMANN, NORMA DE MAGALHÃES, ROSE MARRY ARAÚJO GONDIM-TOMAZ, NELSON PAULIERI SABINO, JÚLIO ISAO KONDO, and ANÍSIO AZZINI. "DETERMINAÇÃO DO NÚMERO E DO ÂNGULO DE CONVOLUÇÃO DA FIBRA DE ALGODÃO E SUA RELAÇÃO COM PROPRIEDADES TECNOLÓGICAS DA FIBRA E DO FIO." Bragantia 57, no. 2 (1998): 279–83. http://dx.doi.org/10.1590/s0006-87051998000200010.
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A linhagem de algodoeiro IAC 20-233 e as variedades comerciais IAC 21 e IAC 22 foram caracterizadas morfologicamente pelo número e pelo ângulo de convolução de suas fibras, utilizando-se microscopia óptica. A variedade IAC 21 apresentou fibras com menor número e ângulo de convolução que a IAC 20-233 e a IAC 22, enquanto estas foram semelhantes entre si. Os três genótipos apresentaram fibras de maturidade similar. O índice Micronaire (medida do complexo finura + maturidade) da variedade IAC 21 foi maior que o dos demais, correspondendo, portanto, a fibras mais grossas. Isso pode ter contribuído para diminuir o número e o ângulo de convolução e, como conseqüência, deprimido a elongação da fibra e do fio de algodão produzido.