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Journal articles on the topic 'IBG invariant'

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Published: 2 June 2025

Last updated: 31 July 2025

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1

Popov, Eugene, та Julia Gumanovskaya. "Игра как метод гармонизации противоречий с целью превращения их в движущую силу развития, часть 2 (Game as a method of contradictions harmonizing in order to turn them into a driving force of development, part 2)". Устойчивое инновационное развитие: проектирование и управление 11, № 1 (26) (2015): 66–75. https://doi.org/10.5281/zenodo.18150.

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The article clarifies the distinction between “contradiction” and “conflict” notions (proposed in its first part) based on conflictological works of P.G. Kuznetsov, L. Kriesberg, J.W. Burton et al. It reviews the options of monitoring the achievement of interdisciplinary business game (IBG) remote sub-goal — formation of a new way of thinking among its participants. In addition, the article proposes IBG invariant in LT-dimension — as a basis for constructing a system of parameters for evaluation of the IBG process and results, as well as a foundation for the

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Praena, José Ángel, and Alejandro Carballar. "Integrated Bragg Grating Spectra." Photonics 12, no. 4 (2025): 351. https://doi.org/10.3390/photonics12040351.

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In this paper, we present a general methodology suitable for analyzing any IBG (Integrated Bragg Grating) as a linear time-invariant (LTI) system using the effective refractive index (ERI) and transfer matrix method (TMM). This approach is based on the translation of the IBG’s physical structure into a matrix of effective refractive indexes, neff, which is wavelength-dependent and describes the behavior of light in the IBG while avoiding the use of approximations like Coupled Mode Theory does. This procedure allows to obtain very accurate reflection and transmission spectra, regardless of the

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Bhaskara, Kieran, and Adam Van Tuyl. "Comparing invariants of toric ideals of bipartite graphs." Proceedings of the American Mathematical Society, Series B 10, no. 19 (2023): 219–32. http://dx.doi.org/10.1090/bproc/174.

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Let G G be a finite simple graph and let I G I_G denote its associated toric ideal in the polynomial ring R R . For each integer n ≥ 2 n\geq 2 , we completely determine all the possible values for the tuple ( reg ⁡ ( R / I G ) , deg ⁡ ( h R / I G ( t ) ) , pdim ⁡ ( R / I G ) , depth ⁡ ( R / I G ) , dim ⁡ ( R / I G ) ) (\operatorname {reg}(R/I_G), \deg (h_{R/I_G}(t)), \operatorname {pdim}(R/I_G), \operatorname {depth}(R/I_G), \dim (R/I_G)) when G G is a connected bipartite graph on n n vertices.

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Lienert, Matthias, and Lukas Nickel. "Multi-time formulation of particle creation and annihilation via interior-boundary conditions." Reviews in Mathematical Physics 32, no. 02 (2019): 2050004. http://dx.doi.org/10.1142/s0129055x2050004x.

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Interior-boundary conditions (IBCs) have been suggested as a possibility to circumvent the problem of ultraviolet divergences in quantum field theories. In the IBC approach, particle creation and annihilation is described with the help of linear conditions that relate the wave functions of two sectors of Fock space: [Formula: see text] at an interior point [Formula: see text] and [Formula: see text] at a boundary point [Formula: see text], typically a collision configuration. Here, we extend IBCs to the relativistic case. To do this, we make use of Dirac’s concept of multi-time wave functions,

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Zhang, Qian S., Jérôme Goudet, and Bruce S. Weir. "Rank-invariant estimation of inbreeding coefficients." Heredity 128, no. 1 (2021): 1–10. http://dx.doi.org/10.1038/s41437-021-00471-4.

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AbstractThe two alleles an individual carries at a locus are identical by descent (ibd) if they have descended from a single ancestral allele in a reference population, and the probability of such identity is the inbreeding coefficient of the individual. Inbreeding coefficients can be predicted from pedigrees with founders constituting the reference population, but estimation from genetic data is not possible without data from the reference population. Most inbreeding estimators that make explicit use of sample allele frequencies as estimates of allele probabilities in the reference population

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de Aguiar, Cristhiane Favero, Angela Castoldi, Mariane T. Amano, et al. "Fecal IgA Levels and Gut Microbiota Composition Are Regulated by Invariant Natural Killer T Cells." Inflammatory Bowel Diseases 26, no. 5 (2019): 697–708. http://dx.doi.org/10.1093/ibd/izz300.

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Abstract Background The gut microbiota is a key element to support host homeostasis and the development of the immune system. The relationship between the microbiota and immunity is a 2-way road, in which the microbiota contributes to the development/function of immune cells and immunity can affect the composition of microbes. In this context, natural killer T cells (NKT cells) are distinct T lymphocytes that play a role in gut immunity and are influenced by gut microbes. In our work, we investigated the involvement of invariant NKT cells (iNKT) in intestinal homeostasis. Results We found that

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Rampal, Ritika, Nahidul Wari, Amit Kumar Singh та ін. "Retinoic Acid Is Elevated in the Mucosa of Patients With Active Ulcerative Colitis and Displays a Proinflammatory Role by Augmenting IL-17 and IFNγ Production". Inflammatory Bowel Diseases 27, № 1 (2020): 74–83. http://dx.doi.org/10.1093/ibd/izaa121.

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Abstract Background All-trans retinoic acid (RA) plays a crucial role in promoting Foxp3+ Treg generation while reciprocally inhibiting Th1/Th17 generation. Our previous research highlighted that in the face of inflammatory conditions, RA plays a contrary role where it aggravates intestinal inflammation by promoting interferon (IFN) γ and interleukin (IL)-17 differentiation in vitro. Methods In this study we translated our in vitro results into a clinical setting where we estimated mucosal and serum RA levels along with the immunophenotypic profile (IL-17, IFNγ, Foxp3, IL-10) in adaptive (CD4,

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Burrello, Claudia, Gabriella Pellegrino, Maria Rita Giuffrè, et al. "Mucosa-associated microbiota drives pathogenic functions in IBD-derived intestinal iNKT cells." Life Science Alliance 2, no. 1 (2019): e201800229. http://dx.doi.org/10.26508/lsa.201800229.

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Inflammatory bowel disease (IBD) pathogenesis has been linked to the aberrant activation of the Gut-associated lymphoid tissues against components of the intestinal microbiota. Although the contribution of CD4+ T helper cells to inflammatory processes is being increasingly acknowledged, the functional engagement of human invariant natural killer T (iNKT) cells is still poorly defined. Here, we evaluated the functional characteristics of intestinal iNKT cells during IBD pathogenesis and to exploit the role of mucosa-associated microbiota recognition in triggering iNKT cells’ pro-inflammatory re

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Bosáková, V., and J. Frič. "DOP08 Cellular and molecular interaction of MAIT in mucosal tissue and their role in inflammatory bowel disease." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i67. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0048.

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Abstract Background Inflammatory bowel disease (IBD) manifests as chronic inflammation of the gastrointestinal tract and is characterized by a deregulated immune response targeting the gut microflora. Mucosal-associated invariant T (MAIT) cells have been identified as a possible key player in IBD. Activated MAIT cells produce cytokines including IL-26, a newly discovered cytokine involved in the pathology of IBD. Interestingly, IL-26 is not expressed in mice and therefore its effect on the course of inflammation has not been yet fully investigated. Similarly, studies employing human cell cultu

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Yasutomi, Y., A. Chiba, K. Haga, et al. "P028 A pathogenic role of activated mucosal-associated invariant T cells in an animal model of Inflammatory Bowel Disease." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i284. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0158.

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Abstract Background It is known that the mucosal-associated invariant T (MAIT) cells are the innate-like T cells that are restricted by the major histocompatibility complex-related molecule 1 (MR1), and that these cells express a semi-invariant T cell receptor. We have previously reported that the activation status of the circulating MAIT cells in patients with Ulcerative Colitis (UC) is associated with disease activity, and these cells infiltrate the inflamed colonic mucosa. These findings imply that MAIT cells are involved in the pathogenesis of Inflammatory Bowel Disease (IBD). However, the

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Katkar, Gajanan Dattatray, Ibrahim Sayed, Mahitha Shree Anandachar, et al. "AI-guided use of balanced peroxisome proliferator-activated receptor a/g dual agonist finetunes macrophage responses in inflammatory bowel disease." Journal of Immunology 206, no. 1_Supplement (2021): 109.01. http://dx.doi.org/10.4049/jimmunol.206.supp.109.01.

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Abstract A computational platform, the Boolean network explorer (BoNE) has recently been developed; it enables querying and navigating invariant Boolean Implication Networks of disease maps for prioritizing high-value targets. Here we used BoNE derived Inflammatory Bowel Disease (IBD)-map and prioritize two nuclear receptors, PPARa and PPARg. Balanced agonism of PPARa/g was predicted to impact macrophage function, ameliorate colitis in network-prioritized animal models, ‘reset’ the gene expression network from disease to health. Predictions were validated using a balanced and potent PPARa/g-du

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Strati, F. "P015 iNKT cells immunomodulation and mucosal healing by microbiota-derived lactate." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i264. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0145.

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Abstract Background Invariant natural killer T (iNKT) cells are unconventional, CD1d-restricted, T lymphocytes playing a critical role in mucosal immune homeostasis. iNKT cells plastically adapt their functional phenotypes to the surrounding environment and are involved in IBD pathogenesis. Although iNKT cells release proinflammatory cytokines in response to the altered gut microbiota of IBD patients, exposure to microbiota-derived metabolites can promote homeostatic IL10-mediated iNKT responses resulting in better clinical outcomes in Crohn's disease (CD) patients. Thus, understanding the mec

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Bao, Bin, Youyuan Wang, Pavl Boudreau, et al. "BACTERIAL SPHINGOLIPIDS EXACERBATE COLITIS BY INHIBITING ILC3-DERIVED IL-22 PRODUCTION." Inflammatory Bowel Diseases 30, Supplement_1 (2024): S63. http://dx.doi.org/10.1093/ibd/izae020.133.

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Abstract Commensal bacteria of the Bacteroidetes phylum are the primary producers of sphingolipids in the gut lumen. These lipids serve dual roles as bacterial virulence factors and regulators of the host mucosal immune system, including regulatory T cells and invariant natural killer T cells (iNKT). Sphingolipid composition is significantly altered in fecal samples of patients with inflammatory bowel disease (IBD). However, the specific mechanisms by which bacterial sphingolipids modulate mucosal homeostasis and regulate intestinal inflammation remain unclear. In this study, we investigated t

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Williams, K., D. Shows, R. Kongala, A. Clarke, and J. Lord. "DOP01 The effect of vedolizumab on CD8 T cell repertoire homogeneity and blood-gut trafficking in patients with inflammatory bowel disease." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i59. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0041.

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Abstract Background Inflammatory bowel disease (IBD) causes T cell to infiltrate intestinal mucosa, but the heterogeneity of these cells is not understood at a clonal level. The anti-integrin α4β7 agent vedolizumab is believed to treat IBD by blocking this T cell infiltration from blood. Methods To understand the clonal distribution of T cells in IBD and how this is affected by vedolizumab, we studyined the T cell receptor (TCR) repertoire in CD8+ T cell subsets sorted from blood samples and colon mucosal biopsies via FACS. Inflamed or uninflamed colon segments from 15 ulcerative colitis and 1

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Persaud, Naraine, Moustafa Elrashidi, Xiaobo Zhou, Xining Zhao, and Xiaoli Chen. "Invariance in the Seasonal Median Dates for Mono-Modal Monsoonal Rainfall Distribution over the Semi-Arid Ecotone of Sub-Saharan West Africa." International Journal of Geosciences 04, no. 06 (2013): 1–7. http://dx.doi.org/10.4236/ijg.2013.46a2001.

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Wu, Jin, Xiaorui Xue, and Jiansong Zhang. "Invariant Signature, Logic Reasoning, and Semantic Natural Language Processing (NLP)-Based Automated Building Code Compliance Checking (I-SNACC) Framework." Journal of Information Technology in Construction 28 (January 24, 2023): 1–18. http://dx.doi.org/10.36680/j.itcon.2023.001.

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Traditional manual building code compliance checking is costly, time-consuming, and human error-prone. With the adoption of Building Information Modeling (BIM), automation in such a checking process becomes more feasible. However, existing methods still face limited automation when applied to different building codes. To address that, in this paper, the authors proposed a new framework that requires minimal input from users and strives for full automation, namely, the Invariant signature, logic reasoning, and Semantic Natural language processing (NLP)-based Automated building Code compliance C

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Liao, Chia-Min, Michael Zimmer, Hoonsik Cho, et al. "The role of CD1d-restricted type II NKT cells in the pathogenesis of inflammatory bowel disease (93.10)." Journal of Immunology 184, no. 1_Supplement (2010): 93.10. http://dx.doi.org/10.4049/jimmunol.184.supp.93.10.

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Abstract CD1d is an MHC class Ib molecule that is specialized to present lipid antigens to NKT cells. Two subsets of NKT cells have been identified: type I NKT cells express an invariant TCR α chain while type II NKT cells express a more diverse TCR repertoire. Recent studies have shown that a specific pattern of CD1d expression is required for proper development and function of type I NKT cells. However, little is known about the regulation and selection of type II NKT cells as there is no method for direct detection of these cells. To address whether changes in CD1d expression patterns can r

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Williams, Kyle, Donna Shows, Ramya Kongala, Duncan Hindmarch, Astrid Clarke, and James Lord. "THE EFFECT OF VEDOLIZUMAB ON CD8 T CELL REPERTOIRE HOMOGENEITY AND BLOOD-GUT TRAFFICKING IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE." Inflammatory Bowel Diseases 29, Supplement_1 (2023): S80—S81. http://dx.doi.org/10.1093/ibd/izac247.154.

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Abstract BACKGROUND Inflammatory bowel disease (IBD) causes T cell infiltration of the intestinal mucosa, but the heterogeneity of these cells is not understood at a clonal level. The drug vedolizumab is believed to treat IBD by blocking the entry of circulating integrin α4β7+ T cells into the intestinal mucosa. METHODS We sought to understand the clonal distribution of T cells in IBD and how this is affected by vedolizumab by studying the T cell receptor (TCR) repertoire in CD8+ T cell subsets sorted from blood samples and colon mucosal biopsies via FACS. Inflamed or uninflamed colon segments

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Lazzarotti, Fábio, Rosilene Marcon, and Rodrigo Bandeira-de-Mello. "RECURSOS PARA INOVAÇÃO E DESEMPENHO: UMA ANÁLISE DA INVARIÂNCIA DE MENSURAÇÃO EM FIRMAS DE SETORES DE ALTA INTENSIDADE TECNOLÓGICA, NO BRASIL." Review of Administration and Innovation - RAI 11, no. 4 (2015): 33. http://dx.doi.org/10.11606/rai.v11i4.100272.

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Este estudo tem por objetivo analisar um modelo teórico que estabelece relações entre recursos para inovação e desempenho e, especificamente, verificar se o modelo é estável ao longo do tempo. A investigação adotou a técnica de análise multigrupos para análise de invariância de mensuração a partir da modelagem de equações estruturais. Usaram-se microdados da pesquisa de inovação tecnológica (PINTEC) do IBGE, referente às edições de 2003, 2005 e 2008. Evidencia-se que o modelo teórico é invariante na equivalência de estrutura fatorial. Nos demais tipos de invariância de mensuração, o modelo não

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Doyle, Chloe, Kirstie Bertram, Jake Rhodes, et al. "A NOVEL LANGERIN EXPRESSING TYPE 2-CONVENTIONAL DENDRITIC CELL IS SIGNIFICANTLY DECREASED IN CROHN’S DISEASE." Inflammatory Bowel Diseases 27, Supplement_1 (2021): S32—S33. http://dx.doi.org/10.1093/ibd/izaa347.076.

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Abstract Crohn’s disease is a chronic relapsing auto-inflammatory condition of the gastrointestinal tract that primarily affects young individuals with an increasing incidence rate. There is still no cure for Crohn’s disease and current treatment-options are limited to controlling inflammatory molecules such as TNF. Unfortunately, these biologics can produce significant side effects and not all patients respond to anti-TNF treatment. New treatments are therefore urgently needed. Targeting the cells and molecules of the immune system still represents the most promising approach which is why we

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Mahdy, A., H. ElAbd, V. Kriukova, et al. "P0125 Crohn’s-associated invariant T Cells are associated with disease severity and location and are not affected by medication intake." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i507—i508. https://doi.org/10.1093/ecco-jcc/jjae190.0299.

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Abstract Background Multiple alterations in the immune repertoire of IBD patients have been identified including, an expansion of a subset of type II natural killer T cells in CD patients, termed Crohn’s-associated invariant T cells (CAIT)1. Previously, we showed that CAIT cells respond to small molecules that resemble multiple microbial and drug metabolites2. This begs the question of whether CAIT cells are expanded due to the ongoing disease or the medications administrated to control the disease. Methods We profiled the T cell receptor alpha chain repertoire of 246 symptomatic controls, 228

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Baumrucker, Camille C., Ganesan Ramamoorthi, William Dominguez-Viqueira, and Brian J. Czerniecki. "Abstract 6150: Intramammary gland activation of invariant natural killer T cells with anti-tumor CD4Th1 cells prevents the development of invasive mammary carcinoma." Cancer Research 85, no. 8_Supplement_1 (2025): 6150. https://doi.org/10.1158/1538-7445.am2025-6150.

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Breast cancer (BC) remains one of the most prevalent cancers in the world thus prompting efforts in risk reduction and prevention. Current strategies for prevention are limited to hormone therapy or prophylactic surgery, which are not without complication. Patients with preinvasive malignant lesions of the breast, including ductal carcinoma in situ (DCIS), if left untreated or after surgical resection, have a higher risk of developing invasive BC (IBC). In addition, clinical studies have shown that a subset of DCIS patients who did not progress to invasive disease died from recurrence or dista

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Cao, Siyan, Kaiming Ma, and Parakkal Deepak. "IL-23-ACTIVATED CELLS PREDICT RESPONSE TO RISANKIZUMAB IN CROHN’S DISEASE." Inflammatory Bowel Diseases 31, Supplement_1 (2025): S56—S57. https://doi.org/10.1093/ibd/izae282.135.

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Abstract BACKGROUND & AIMS The interleukin (IL)-23 signaling plays a crucial role in the pathogenesis of Crohn’s disease (CD). IL-23 activates T-helper (Th) 17 cells, IL-17-secreting CD8 T (Tc)17 cells, γδ T cells, nature killer (NK) T cells, and group 3 innate lymphoid cells (ILC3) to secrete proinflammatory cytokines including IL-17, IFN-γ, and TNF-α. Risankizumab is the first selective IL-23 antagonist approved for moderately to severely active CD. However, there is currently no biomarker to predict response to anti-IL-23 antibodies in IBD. Here, we characterized the cell type- and cyto

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Almeida, Alexandre Nunes, Domingos Isaias Maia Amorim, Carlos Roberto Azzoni, Francisco José Silva Tabosa, and André Luiz Squarize Chagas. "Gastos Domiciliares nas Regiões Metropolitanas: Uma Análise não Paramétrica Kernel usando Dados de Pseudo-Painel." Revista Brasileira de Estudos Regionais e Urbanos 14, no. 4 (2020): 574–600. http://dx.doi.org/10.54766/rberu.v14i4.700.

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O objetivo deste trabalho é analisar a relação entre a parcela despendida entre itens alimentícios (e não alimentícios) e o gasto domiciliar total através de modelos de regressão kernel não paramétricos. Para atender este objetivo, foram utilizados dados de um pseudo-painel construído a partir das Pesquisas de Orçamentos Familiares do IBGE entre 1987 e 2009. Observou-se que os resultados dos modelos paramétricos não se mostraram significativamente diferentes das estimativas médias não paramétricas entre os diferentes grupos de consumo. No entanto, ao analisar as estimativas não paramétricas na

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Zemp, Franz, Christopher Waterhouse, and Paul Kubes. "Intravital imaging of the colonic mucosa: analysis of iNKT physiology during health and disease (MUC5P.752)." Journal of Immunology 194, no. 1_Supplement (2015): 138.10. http://dx.doi.org/10.4049/jimmunol.194.supp.138.10.

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Abstract Invariant natural killer T-cells (iNKTs) are specialized innate-like T cells that respond to glycolipid antigens with the rapid secretion of polarizing cytokines. Recent literature has shown that iNKTs are important in mouse models of IBD, but have failed to demonstrate the role of colonic iNKTs specifically. Further, the behavior of these cells has never been observed in the gut. Using intravital spinning disk confocal microscopy and transgenic mice that label iNKT cells, we found that iNKTs actively survey the colonic lamina propria. These cells arrested upon administration of a gly

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Ovchinnikov, Ilya, and Vladimir Mavzovin. "Modeling the stress-strain state of a circular plate subject to general corrosion according to various models." E3S Web of Conferences 263 (2021): 03009. http://dx.doi.org/10.1051/e3sconf/202126303009.

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Quite a lot of works have been devoted to the problem of modeling the behavior of thin-walled structures exposed to an aggressive environment leading to corrosive wear of their surface. Researchers have proposed a fairly large set of models of corrosive wear, taking into account the influence of various factors on the kinetics of corrosion (time, material, temperature, the nature of the corrosive environment, the stress-strain state of the structure). Moreover, different authors often propose different models for the same conditions. In the article under consideration, a rather unique comparat

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Е.А., Серова. "Социально-психологические особенности ценностных ориентаций молодых и «серебряных» волонтеров". Человеческий капитал, № 1(169) (21 січня 2023): 175–81. http://dx.doi.org/10.25629/hc.2023.01.20.

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Актуальность темы статьи обусловлена необходимостью изучения различий в ценностных ориентациях представителей разных поколений, включенных в волонтерскую деятельность, для последующей возможности моделирования новых форм управления волонтерством с учетом межпоколенческих особенностей. Цель исследования - изучение социально-психологических особенностей ценностей волонтеров молодого и «серебряного» возраста. В статье рассматриваются теоретические подходы к понятию терминальных ценностей, ценностных ориентаций волонтерства, волонтерской деятельности. Объект исследования - волонтеры молодого и «се

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Wild, Benjamin, Geert J. Verhoeven, Rafał Muszyński, and Norbert Pfeifer. "Detecting change in graffiti using a hybrid framework." Photogrammetric Record 39, no. 187 (2024): 549–76. https://doi.org/10.1111/phor.12496.

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Rosati, Elisa, Gabriela Rios Martini, Mikhail V. Pogorelyy, et al. "A novel unconventional T cell population enriched in Crohn’s disease." Gut, March 9, 2022, gutjnl—2021–325373. http://dx.doi.org/10.1136/gutjnl-2021-325373.

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ObjectiveOne of the current hypotheses to explain the proinflammatory immune response in IBD is a dysregulated T cell reaction to yet unknown intestinal antigens. As such, it may be possible to identify disease-associated T cell clonotypes by analysing the peripheral and intestinal T-cell receptor (TCR) repertoire of patients with IBD and controls.DesignWe performed bulk TCR repertoire profiling of both the TCR alpha and beta chains using high-throughput sequencing in peripheral blood samples of a total of 244 patients with IBD and healthy controls as well as from matched blood and intestinal

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Mballo, Chams Eddine, and J. V. R. Prasad. "Individual Blade Control for Component Load Alleviation Using Higher-Order Linear Time-Invariant Models." Journal of the American Helicopter Society, 2024. http://dx.doi.org/10.4050/jahs.69.032002.

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This paper explores the synthesis of a novel load alleviation scheme based on active rotor control for critical helicopter component life extension. The proposed load alleviation scheme is innovative as it demonstrates how individual blade control (IBC) and model prediction can be combined using higher-order linear time-invariant models to develop a life-extending control scheme. Using a reduced-order coupled body-rotor-inflow dynamic model onboard the vehicle and a cost function, cost-minimizing higher harmonic IBC inputs are computed over a selected time horizon and used to reduce selected h

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Sun, Dajuan, Lili Chi, Jiahui Liu, Junwei Liang, Song Guo, and Shaojie Li. "Psychometric validation of the Chinese version of the Short Inflammatory Bowel Disease Questionnaire and evaluation of its measurement invariance across sex." Health and Quality of Life Outcomes 19, no. 1 (2021). http://dx.doi.org/10.1186/s12955-021-01890-x.

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Abstract Background This study aimed to evaluate the psychometric properties of the Chinese version of the Short Inflammatory Bowel Disease Questionnaire (C-SIBDQ), and its measurement invariance across sex in Chinese patients with inflammatory bowel disease (IBD). Methods Between September 2018 and July 2021, 284 patients with IBD were recruited from a spleen and stomach clinic. All participants completed the C-SIBDQ, 12-item Short-Form Health Survey (SF-12), nine-item Patient Health Questionnaire Depression Scale (PHQ-9), and the seven-item Generalized Anxiety Disorder Scale (GAD-7). Floor a

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Barello, Serena, Elena Guida, Andrea Bonanomi, et al. "We-care ibd score: assessing high-quality care in the perspective of patients with inflammatory bowel diseases." Journal of Crohn's and Colitis, August 26, 2020. http://dx.doi.org/10.1093/ecco-jcc/jjaa174.

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Abstract Background and Aims PREMs are today a core asset to orient healthcare quality improvements. They are particularly relevant in clinical situations requiring frequent interactions between patients and the healthcare system, like inflammatory bowel disease (IBD). Indeed, IBD chronic care requires continuous therapies, psychological interventions and follow-ups. The characteristics of healthcare services play an important role in the life of these patients and in their satisfaction with the care received. The aim of this study was to develop and validate an IBD-specific questionnaire (WE-

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Japanese Journal of Clinical Immunology 37, № 4 (2014): 309a. http://dx.doi.org/10.2177/jsci.37.309a.

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Fang, Ying, Yuning Chen, Siyue Niu, et al. "Biological functions and therapeutic applications of human mucosal-associated invariant T cells." Journal of Biomedical Science 32, no. 1 (2025). https://doi.org/10.1186/s12929-025-01125-x.

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Abstract Mucosal-associated invariant T (MAIT) cells are a unique subset of innate-like T lymphocytes that bridge innate and adaptive immunity. Characterized by their semi-invariant T cell receptor (TCR) and abundant localization in mucosal tissues, MAIT cells recognize microbial metabolites, primarily derived from the riboflavin biosynthesis pathway, presented by the major histocompatibility complex (MHC)-related protein 1 (MR1). This interaction, along with co-stimulatory signals, triggers rapid immune responses, including cytokine secretion and cytotoxic activity, highlighting their importa

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Katkar, Gajanan D., Ibrahim M. Sayed, Mahitha Shree Anandachar та ін. "Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease". Communications Biology 5, № 1 (2022). http://dx.doi.org/10.1038/s42003-022-03168-4.

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AbstractA computational platform, Boolean network explorer (BoNE), has recently been developed to infuse AI-enhanced precision into drug discovery; it enables invariant Boolean Implication Networks of disease maps for prioritizing high-value targets. Here we used BoNE to query an Inflammatory Bowel Disease (IBD)-map and prioritize a therapeutic strategy that involves dual agonism of two nuclear receptors, PPARα/γ. Balanced agonism of PPARα/γ was predicted to modulate macrophage processes, ameliorate colitis, ‘reset’ the gene expression network from disease to health. Predictions were validated

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Dr. Pinky Rani. "The B (E2) transition Probabilities for 122-130Te (Tellurium) Even-Even Isotopes with the help of Cubic terms from Casimir Invariant Operators and IBM-1." Nanotechnology Perceptions, December 7, 2024, 208–15. https://doi.org/10.62441/nano-ntp.vi.3702.

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The interacting boson model-1 has been used to calculate the reduced electric transition probability B(E2) ↓ of even-even 122-130Te (Tellurium) isotopes with even neutrons from N = 70 to 78. The three-three boson interactions are also formed in the Hamiltonian from Casimir invariant operators. The parameters of best fit to measure the data are used from the experimental value of B (E2; 21+ → 01+) for even-even 122-130Te isotopes. The theoretical values are good in agreement especially with the experimental ones. The branching ratios B (E2; 41+ → 21+) / B (E2; 21+ → 01+) is less than 2 represen

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Vo, Daniella, Shayal Charisma Singh, Sara Safa, and Debashis Sahoo. "Boolean implication analysis unveils candidate universal relationships in microbiome data." BMC Bioinformatics 22, no. 1 (2021). http://dx.doi.org/10.1186/s12859-020-03941-4.

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Abstract Background Microbiomes consist of bacteria, viruses, and other microorganisms, and are responsible for many different functions in both organisms and the environment. Past analyses of microbiomes focused on using correlation to determine linear relationships between microbes and diseases. Weak correlations due to nonlinearity between microbe pairs may cause researchers to overlook critical components of the data. With the abundance of available microbiome, we need a method that comprehensively studies microbiomes and how they are related to each other. Results We collected publicly av

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Kasler, Herbert G., Intelly S. Lee, Hyung W. Lim, and Eric Verdin. "Histone Deacetylase 7 mediates tissue-specific autoimmunity via control of innate effector function in invariant Natural Killer T Cells." eLife 7 (April 17, 2018). http://dx.doi.org/10.7554/elife.32109.

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We report that Histone Deacetylase 7 (HDAC7) controls the thymic effector programming of Natural Killer T (NKT) cells, and that interference with this function contributes to tissue-specific autoimmunity. Gain of HDAC7 function in thymocytes blocks both negative selection and NKT development, and diverts Vα14/Jα18 TCR transgenic thymocytes into a Tconv-like lineage. Conversely, HDAC7 deletion promotes thymocyte apoptosis and causes expansion of innate-effector cells. Investigating the mechanisms involved, we found that HDAC7 binds PLZF and modulates PLZF-dependent transcription. Moreover, HDAC

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Wu, Zhengyu, Xingchi Chen, Fei Han, and Edwin Leeansyah. "MAIT cell homing in intestinal homeostasis and inflammation." Science Advances 11, no. 6 (2025). https://doi.org/10.1126/sciadv.adu4172.

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Mucosa-associated invariant T (MAIT) cells are a large population of unconventional T cells widely distributed in the human gastrointestinal tract. Their homing to the gut is central to maintaining mucosal homeostasis and immunity. This review discusses the potential mechanisms that guide MAIT cells to the intestinal mucosa during homeostasis and inflammation, emphasizing the roles of chemokines, chemokine receptors, and tissue adhesion molecules. The potential influence of the gut microbiota on MAIT cell homing to different regions of the human gut is also discussed. Last, we introduce how or

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Jiang, Qinyue, Ciska Lindelauf, Vincent van Unen, Andrea E. van der Meulen‐de Jong, Frits Koning, and M. Fernanda Pascutti. "A 37‐Color Spectral Flow Cytometric Panel to Assess Transcription Factors and Chemokine Receptors in Human Intestinal Lymphoid Cells." Cytometry Part A, January 21, 2025. https://doi.org/10.1002/cyto.a.24914.

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ABSTRACTWe have developed a 37‐color spectral flow cytometry panel to assess the phenotypical differentiation of innate and adaptive immune lymphoid subsets within human intestinal tissue. In addition to lineage markers for identifying innate lymphoid cells (ILC), TCRγδ, MAIT (mucosal‐associated invariant T), natural killer (NK), CD4+ and CD8+ T cells, we incorporated markers of differentiation and activation (CD45RA, CD45RO, CD25, CD27, CD38, CD39, CD69, CD103, CD127, CD161, HLA‐DR, CTLA‐4 [CD152]), alongside transcription factors (Bcl‐6, FoxP3, GATA‐3, Helios, T‐bet, PU.1 and RORγt) and chem

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Lett, Martin J., Hema Mehta, Adrian Keogh, et al. "Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells." Gut, January 20, 2022, gutjnl—2021–324478. http://dx.doi.org/10.1136/gutjnl-2021-324478.

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ObjectiveMucosal-associated invariant T (MAIT) cells are the most abundant T cells in human liver. They respond to bacterial metabolites presented by major histocompatibility complex-like molecule MR1. MAIT cells exert regulatory and antimicrobial functions and are implicated in liver fibrogenesis. It is not well understood which liver cells function as antigen (Ag)-presenting cells for MAIT cells, and under which conditions stimulatory Ags reach the circulation.DesignWe used different types of primary human liver cells in Ag-presentation assays to blood-derived and liver-derived MAIT cells. W

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Inglese, Guglielmo. "The rise of middle voice systems." Diachronica, January 19, 2023. http://dx.doi.org/10.1075/dia.20058.ing.

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Abstract Middle markers are characterized by a distribution halfway between grammar and the lexicon: with some verbs, middle marking encodes valency change, while with others it obligatorily occurs with no obvious synchronic motivation. Despite the existing cross-linguistic work on middle markers, their history is still largely unknown. In the typological literature, the standard view is that middle markers predominantly have their origin in reflexive markers, and that, in their development, it is invariantly the grammatical component that expands to the lexical component. In this paper, I cha

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Trindade, Inês A., Laurie Keefer, Francisco Portela, Cláudia Ferreira, and José Pinto-Gouveia. "Measuring structural model invariance across internet-recruited and hospital-recruited IBD patients: Experiential avoidance’s effect on psychopathological symptoms." Current Psychology, May 11, 2019. http://dx.doi.org/10.1007/s12144-019-00281-2.

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Brauns, Steffen, Isabel Marquardt, Cosima Thon, et al. "Mucosal-associated invariant T (MAIT) cells from Clostridioides difficile-infected patients exhibit a distinct proinflammatory phenotype and enhanced cytotoxic activity." International Immunology, August 7, 2023. http://dx.doi.org/10.1093/intimm/dxad032.

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Abstract Mucosal-associated invariant T (MAIT) cells are innate-like T cells mainly found in the mucosa and peripheral blood. We have recently demonstrated that Clostridioides difficile activates MAIT cell in vitro. However, their role in the pathogenesis of C. difficile infection (CDI) in human patients remains elusive to date. In this study, we performed comprehensive immunophenotyping of MAIT cells derived from CDI patients and compared their phenotype to that of patients with inflammatory bowel diseases (IBD). Our study revealed that blood MAIT cells from CDI patients exhibit an interleuki

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Ghanem, Safwan, Priyadarshi Kanungo, Ganapati Panda, Suresh Chandra Satapathy, and Rohit Sharma. "Lane detection under artificial colored light in tunnels and on highways: an IoT-based framework for smart city infrastructure." Complex & Intelligent Systems, May 2, 2021. http://dx.doi.org/10.1007/s40747-021-00381-2.

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AbstractLane detection (LD) under different illumination conditions is a vital part of lane departure warning system and vehicle localization which are current trends in the future smart cities. Recently, vision-based methods are proposed to detect lane markers in different road situations including abnormal marker cases. However, an inclusive framework for driverless cars has not been introduced yet. In this work, a novel LD and tracking method is proposed for the autonomous vehicle in the IoT-based framework (IBF). The IBF consists of three modules which are vehicle board (VB), cloud module

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Santhosh Kumar, P., K. Kalaivani, and R. Balakrishna. "Enhanced Segmentation and Ensemble Classification for Accurate Plant Disease Detection." Journal of Phytopathology 172, no. 6 (2024). https://doi.org/10.1111/jph.13426.

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ABSTRACTThe majority of the crops are wasted owing to deficiency of transport, plant diseases and lack of storage facilities. Above 15% of crops are worn out in India owing to diseases and therefore it has turned out to be a main concern to be solved. This study introduces an advanced framework for plant disease detection by integrating enhanced image segmentation techniques with robust ensemble classification models. Our methodology begins with the pre‐processing of plant leaf images using median filtering and Wiener denoising to reduce noise and enhance image quality. As the next step, the I

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Zhang, Peng, Yanan Yang, Yuanfeng Xu, and Zhaoxia Cui. "Analyses of the Dmrt family in a decapod crab, Eriocheir sinensis uncover new facets on the evolution of DM domain genes." Frontiers in Physiology 14 (May 26, 2023). http://dx.doi.org/10.3389/fphys.2023.1201846.

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DM domain genes are a group of transcription factors that are integral to sexual development and its evolution in metazoans. Their functions and regulatory mechanisms are not well understood in Malacostraca (crabs and crayfish) while these sex regulators have been widely identified in the past decade. In this study, the Dmrt family was investigated in the decapod crab, Eriocheir sinensis. We find that most members of the EsDmrt family begin to enrich around the juvenile 1 stage. In reproductive organs, EsDsx1, EsDsx2, EsiDMY and EsiDmrt1a highly express in the male-specific androgenic gland (A

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Navarro-Compán, Victoria, Luis Puig, Silvia Vidal, et al. "The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases." Frontiers in Immunology 14 (August 4, 2023). http://dx.doi.org/10.3389/fimmu.2023.1191782.

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Interleukin-17 family (IL-17s) comprises six structurally related members (IL-17A to IL-17F); sequence homology is highest between IL-17A and IL-17F, displaying certain overlapping functions. In general, IL-17A and IL-17F play important roles in chronic inflammation and autoimmunity, controlling bacterial and fungal infections, and signaling mainly through activation of the nuclear factor-kappa B (NF-κB) pathway. The role of IL-17A and IL-17F has been established in chronic immune-mediated inflammatory diseases (IMIDs), such as psoriasis (PsO), psoriatic arthritis (PsA), axial spondylarthritis

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Mesquita, Afrânio Rubens de. "Prefácio." Revista Brasileira de Geofísica 31, no. 5 (2013). http://dx.doi.org/10.22564/rbgf.v31i5.392.

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PREFACEThe articles of this supplement resulted from the 5 th International Congress of the Brazilian Geophysical Society held in São Paulo city, Brazil, at the Convention Center of the Transamérica Hotel, from 28 th September to 2 nd of October 1997. The participants of the Round Table Discussions on “Mean Sea Level Changes Along the Brazilian Coast” were Dr. Denizar Blitzkow, Polytechnic School of the University of São Paulo, (POLI-USP), Prof. Dr. Waldenir Veronese Furtado, Institute of Oceanography (IO-USP), Dr. Joseph Harari (IO-USP), Dr. Roberto Teixeira from the Brazilian Institute of Ge

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