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1

Ribeiro, Maria Ângela, and Isabela Heineck. "Estoque domiciliar de medicamentos na comunidade ibiaense acompanhada pelo Programa Saúde da Família, em Ibiá-MG, Brasil." Saúde e Sociedade 19, no. 3 (2010): 653–63. http://dx.doi.org/10.1590/s0104-12902010000300016.

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O objetivo do estudo foi examinar o estoque de medicamentos na comunidade Ibiaense acompanhada pelo Programa Saúde da Família (PSF). Buscou-se descrever as características dos usuários, as condições de armazenamento, as classes terapêuticas, as formas farmacêuticas e a procedência dos medicamentos do estoque caseiro. Foram visitados 285 domicílios, no período de julho a setembro de 2004. Verificou-se que a média de medicamentos por domicílio foi de 8,4, e que 93,5% das famílias entrevistadas apresentaram pelo menos um medicamento em estoque. Os medicamentos estocados em maior número foram: ana
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2

Cocio, Tiago A., Erika Nascimento, Marcia R. von Zeska Kress, Eduardo Bagagli, and Roberto Martinez. "Phylogenetic Species of Paracoccidioides spp. Isolated from Clinical and Environmental Samples in a Hyperendemic Area of Paracoccidioidomycosis in Southeastern Brazil." Journal of Fungi 6, no. 3 (2020): 132. http://dx.doi.org/10.3390/jof6030132.

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Paracoccidioides brasiliensis complex and P. lutzii are the etiological agents of paracoccidioidomycosis. The geographic distribution of these species in South America is still poorly comprehended. Fifty samples of Paracoccidioides spp. were genotyped, with 46 clinical isolates predominantly isolated in the geographic area of Ribeirão Preto, SP, and four environmental isolates collected in Ibiá, MG, southeastern Brazil. These isolates were evaluated by PCR-RFLP (Restriction Fragment Length Polymorphism) of the tub1 gene and the sequencing of the gp43 exon 2 loci. The species P. lutzii was conf
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3

Hashemi, Nasseh, Tim Valk, Kim Houlind, and Niels Ejskjaer. "Insulin-Based Infusion System: Advancing the Development." Journal of Diabetes Science and Technology 13, no. 5 (2019): 941–48. http://dx.doi.org/10.1177/1932296819832876.

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Background: Deviations in glucose control in critical care have been shown to increase mortality and morbidity. However, optimal glucose control through present technologies has shown to be a challenge. The insulin balanced infusion system (IBIS) is a new and emerging technology. Methods: The closed loop system was tested in a stress trial to evaluate glucose stability in response to various conditions in nonrandomized people with type 1 diabetes mellitus (n=12). The prototype used in this trial was based on intermittent capillary measurements. Results: Induced stresses in the study using unpr
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4

Hashemi, Nasseh, Tim Valk, Kim Houlind, and Niels Ejskjaer. "Insulin-Based Infusion System: Preliminary Study." Journal of Diabetes Science and Technology 13, no. 5 (2019): 935–40. http://dx.doi.org/10.1177/1932296818821349.

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Background: Optimal glucose control has been shown to be useful in critical care as well as in other settings. Glucose concentrations in patients admitted to critical care are characterized by marked variability and hypoglycemia due to inadequate sensing and treatment technologies. Methods: The insulin balanced infusion system (IBIS) is a closed-loop system that uses a system controller, two syringe pumps, and capillary glucose sensor intravenously infusing regular insulin and/or dextrose. The IBIS performance was evaluated in terms of glucose stability in response to various conditions in sub
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5

Gomez, Borja, Haydee Diaz, Alba Carro, Javier Benito, and Santiago Mintegi. "Performance of blood biomarkers to rule out invasive bacterial infection in febrile infants under 21 days old." Archives of Disease in Childhood 104, no. 6 (2018): 547–51. http://dx.doi.org/10.1136/archdischild-2018-315397.

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ObjectivesTo determine the performance of procalcitonin (PCT), C reactive protein (CRP) and absolute neutrophil count (ANC) in identifying invasive bacterial infection (IBI) among well-appearing infants ≤21 days old with fever without source and no leukocyturia. To compare this performance with that in those 22–90 days old.DesignSubstudy of a prospective single-centre registry performed between September 2008 and August 2017.SettingPaediatric emergency department of a tertiary teaching hospital.Patients196 infants ≤21 days old and 1331 infants 22–90 days old.Main outcome measuresSensitivity an
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6

Silva, Fernando Vitorino, Marcos Yassuo Kamogawa, Márcia Miguel Castro Ferreira, Joaquim Araújo Nóbrega, and Ana Rita Araujo Nogueira. "Discriminação geográfica de águas minerais do Estado de São Paulo através da análise exploratória." Eclética Química 27, spe (2002): 91–102. http://dx.doi.org/10.1590/s0100-46702002000200008.

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Neste trabalho procurou-se correlacionar e agrupar amostras de água mineral provenientes de diferentes regiões do Estado de São Paulo a partir da análise exploratória dos valores de pH e teores de Ba, Ca, K, Mg, Na e V. Utilizando a análise de componentes principais (ACP) e a análise hierárquica de agrupamentos (AHA) foi possível avaliar a similaridade das amostras analisadas com a formação de grupos que estavam diretamente correlacionados com a procedência ou propriedades da água mineral. Em análise exploratória é utilizado termos como "scores" que fornecem a composição das componentes princi
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7

Liu, Boyan, Yanhui Du, Lixin Cong, Xiaoying Jia, and Ge Yang. "Danshen (Salvia miltiorrhiza) Compounds Improve the Biochemical Indices of the Patients with Coronary Heart Disease." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/9781715.

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Danshen was able to reduce the risk of the patients with coronary heart disease (CHD), but the mechanism is still widely unknown. Biochemical indices (lipid profile, markers of renal and liver function, and homocysteine (Hcy)) are closely associated with CHD risk. We aimed to investigate whether the medicine reduces CHD risk by improving these biochemical indices. The patients received 10 Danshen pills (27 mg/pill) in Dashen group, while the control patients received placebo pills, three times daily. The duration of follow-up was three months. The serum biochemical indices were measured, inclu
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8

Smith, Samuel George, Ivana Sestak, Anthony Howell, John Forbes, and Jack Cuzick. "Participant-Reported Symptoms and Their Effect on Long-Term Adherence in the International Breast Cancer Intervention Study I (IBIS I)." Journal of Clinical Oncology 35, no. 23 (2017): 2666–73. http://dx.doi.org/10.1200/jco.2016.71.7439.

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Purpose To assess the role of participant-reported symptoms on long-term adherence to preventive therapy in the United Kingdom sample of the International Breast Cancer Intervention Study (IBIS-I). IBIS-I was a randomized controlled trial that investigated the effectiveness of tamoxifen in reducing the risk of breast cancer among women at increased risk of the disease. Participants and Methods Women were randomly assigned to tamoxifen versus placebo (20 mg/day; n = 4,279). After 456 exclusions, 3,823 women were included in this analysis. Adherence (< 4.5 years or ≥ 4.5 years) was calculated
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9

Yevizal, Muhammad, Aras Mulyadi, and Ferry Fatnanta. "Analisis pengaruh V/C ratio lalu lintas kendaraan terhadap tingkat polusi udara berdasarkan volume lalu lintas kendaraan (studi di kawasan persimpangan Mall SKA Kota Pekanbaru)." Jurnal Zona 1, no. 2 (2021): 64–74. http://dx.doi.org/10.52364/jz.v2i2.26.

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Completion of the transportation problems in the city of Pekanbaru currently only looked at in terms of congestion, but not touching insights from environmental aspects such as performance air pollution and noise levels. This research was conducted at the observation point road ahead Repair Tambusai lord Eastern Daihatshu, road Tuanku Tambusai West Side Mall SKA, North Soekarno Hatta street front retail outlets, street front Soekarno Hatta South Hotel Ibis Pekanbaru. V / C Ratio highest in the afternoon rush hour on the road ahead Tambusai lord Stations Daihatsu ie 0.86 pelyanan road performan
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10

Matthew, C. B., A. M. Bastille, R. R. Gonzalez, and I. V. Sils. "Heart rate variability and electrocardiogram waveform as predictors of morbidity during hypothermia and rewarming in rats." Canadian Journal of Physiology and Pharmacology 80, no. 9 (2002): 925–33. http://dx.doi.org/10.1139/y02-120.

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This study examined electrocardiogram (ECG) waveform, heart rate (HR), mean blood pressure (BP), and HR variability as potential autonomic signatures of hypothermia and rewarming. Adult male Sprague–Dawley rats had telemetry transmitters surgically implanted, and 2 weeks were allowed for recovery prior to induction of hypothermia. Rats were lightly anesthetized (sodium pentobarbital, 35 mg/kg i.p.) and placed in a coil of copper tubing through which temperature-controlled water was circulated. Animals were cooled to a core temperature (Tc) of 20°C, maintained there for 30 min, and then rewarme
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11

Ankri, Annick, Anne Baranger, Isabelle Martin-Toutain, et al. "Impaired ristocetin–induced Platelet Aggregation in Whole Blood Assessed with a Multiplate© Analyser Suggests a New Mechanism of Antiplatelet Effect of Aspirin and Clopidogrel,." Blood 118, no. 21 (2011): 3362. http://dx.doi.org/10.1182/blood.v118.21.3362.3362.

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Abstract Abstract 3362 The five channel computerized Whole Blood Aggregation instrument (Multiple Platelet Function Analyzer or Multiplate®), assesses platelet aggregation based on a modified whole blood impedance aggregation method. It permits platelet aggregation to be measured after adding commonly used agonists as arachidonic acid (ASPItest), ADP (ADPtest), collagen (COLtest), ristocetin (RISTOtest) and TRAP (TRAPtest), by detecting changes in electrical resistance in whole blood. Instrument handling is easy. Results are available within 9 minutes. Our objective was to evaluate the effect
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12

Horn, L., G. Milne, A. Sandler, et al. "Urine PGE-M to assess prostaglandin E2 (PGE2) levels in non-small cell lung cancer (NSCLC)." Journal of Clinical Oncology 27, no. 15_suppl (2009): e19026-e19026. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e19026.

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e19026 Background: COX-2 is often overexpressed in NSCLC leading to high systemic PGE2 levels that in turn play a role in NSCLC pathogenesis. Changes in urine PGE-M (the major PGE2 metabolite) reflect changes in systemic & intratumoral PGE2 [Csiki et al. Clin Cancer Res 11:6634, 2005]. A ≥70% decline in PGE-M in NSCLC patients (pts) treated with celecoxib (C) (400 mg bid) + docetaxel (D) was associated with an apparent survival benefit [Ibid]. To effect maximum COX-2 inhibition we tested a higher C dose in a subsequent phase II trial. Methods: Eligibility: previously treated NSCLC, PS 0–2,
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13

Askeland, Matthew, Bradley Clarke, and Jorge Paz-Ferreiro. "Comparative characterization of biochars produced at three selected pyrolysis temperatures from common woody and herbaceous waste streams." PeerJ 7 (April 15, 2019): e6784. http://dx.doi.org/10.7717/peerj.6784.

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Biochar, the product of biomass pyrolysis, has been explored as a soil amendment and carbon capture vessel. Recent literature has aligned biochar as a novel sorbent for a host of environmental contaminants. Through the variation of pyrolysis conditions, biochars can be engineered to have qualities desirable in sorbents whilst maintaining their agronomic benefits. This study focuses on identifying the effects that feedstock type and process temperature have on biochar characteristics which may in turn shed light on their potential environmental applications. Using this approach, six biochars we
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14

Canova, Luca, Michela Sturini, Antonella Profumo, and Federica Maraschi. "Evidence of Low-Habitat Contamination Using Feathers of Three Heron Species as a Biomonitor of Inorganic Elemental Pollution." International Journal of Environmental Research and Public Health 17, no. 21 (2020): 7776. http://dx.doi.org/10.3390/ijerph17217776.

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The concentration of 12 elements (As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Se, and Zn) has been investigated in the feathers of three species of Ardeidae, namely the Grey Heron Ardea cinerea, the Little Egret Egretta garzetta, and the Cattle Egret Bubulcus ibis, all breeding at a colony located in the southern Padana Plain (NW Italy). This study is a first step for an evaluation of possible direct effects of these elements on chicks’ survival and growth rate. Fe, Zn, Cu, and Mn were in the range 7–69 mg Kg−1, while lower levels of Pb, Ni, As, and Se (0.27–1.45 mg Kg−1) were measured. Co, Cd, an
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15

Shao, Zonghong, Xifeng Dong, Rong Fu, et al. "Chemotherapy Plus Hematopoietic Growth Factor for Refractory Paroxysmal Nocturnal Hemoglobinuria: Diminishing PNH Clone and Stimulating Hematopoisis." Blood 118, no. 21 (2011): 4376. http://dx.doi.org/10.1182/blood.v118.21.4376.4376.

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Abstract Abstract 4376 BACKGROUND Even complement inhibitor against C5 Eculizumab has been used in the treatment of paroxysmal nocturnal hemoglobinuria (PNH) acting as a “dam” protecting PNH clone and storing higher risk of hemolysis. So we carried out a study to investigate the efficacy and safety of chemotherapy plus growth factors, a traditional treatment for malignant hematological diseases, aiming at diminishing PNH clone and stimulating hematopoisis, in patients with refractory and relapsed PNH. METHODS 10 patients were enrolled in this study. These patients were admitted into General Ho
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16

Federico, Alessandro, Marcello Dallio, Antonietta Gerarda Gravina, et al. "The Bisphenol A Induced Oxidative Stress in Non-Alcoholic Fatty Liver Disease Male Patients: A Clinical Strategy to Antagonize the Progression of the Disease." International Journal of Environmental Research and Public Health 17, no. 10 (2020): 3369. http://dx.doi.org/10.3390/ijerph17103369.

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Introduction: Bisphenol A (BPA) exposure has been correlated to non-alcoholic fatty liver disease (NAFLD) development and progression. We investigated, in a clinical model, the effects of the administration of 303 mg of silybin phospholipids complex, 10 μg of vitamin D, and 15 mg of vitamin E (RealSIL, 100D, IBI-Lorenzini, Aprilia, Italy) in male NAFLD patients exposed to BPA on metabolic, hormonal, and oxidative stress-related parameters. Methods: We enrolled 32 male patients with histologic diagnosis of NAFLD and treated them with Realsil 100D twice a day for six months. We performed at base
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17

Zhou, Jun, Jifang Gong, Yanshuo Cao, et al. "Anlotinib plus TQB2450 in patients with advanced refractory biliary tract cancer (BTC): An open-label, dose-escalating, and dose-expansion cohort of phase Ib trial." Journal of Clinical Oncology 39, no. 3_suppl (2021): 292. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.292.

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292 Background: Anti-angiogenic agents have been clinically investigated in combination with anti-PD-1/L1 mAbs due to their immuno-modulatory effects. Anlotinib (A), a potent oral multi-target tyrosine kinase inhibitor, has anti-angiogenic properties and anti-tumor efficacy with a favorable toxicity profile. The combination of A and TQB2450 (T), an anti-PD-L1 mAb, exhibited superior tumor growth suppression compared to either monotherapy in murine models. This ongoing phase 1b study cohort is aimed to assess the safety and efficacy of A+T in pts with advanced BTC. Methods: In this study cohort
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18

De Jager, Robert L., Howard Bruckner, Fred Bassali, et al. "Blood tests to predict one- to two-year survival of patients with difficult cancers." Journal of Clinical Oncology 39, no. 15_suppl (2021): e16158-e16158. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e16158.

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e16158 Background: A sequence of drug combinations produces > 1 median (M) -strong 2-year (yr) survival (S) (Bruckner et al AACR 14 Antica Res (ACR) 16, 18 SIGO 19). Trials included high-risk patients (pts). Each initial series has 5-yr Ss, after pts were referred for hospice care. Prognostic ALAN blood tests (Ts) have been validated for stage IV (Adv) Cholangiocarcinoma (CCA) (Salati et al EuJCa18). Other Ts predict unexpected favorable (F) S of pts with gastric ca, PS 2-3. Bruckner et al JAMA, 82); but, there is little known about Ts for resistant (R) Ca. Methods: Planned Kaplan-Meier int
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19

Boreham, C. J., J. E. Blevin, A. P. Radlinski, and K. R. Trigg. "COAL AS A SOURCE OF OIL AND GAS: A CASE STUDY FROM THE BASS BASIN, AUSTRALIA." APPEA Journal 43, no. 1 (2003): 117. http://dx.doi.org/10.1071/aj02006.

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Only a few published geochemical studies have demonstrated that coals have sourced significant volumes of oil, while none have clearly implicated coals in the Australian context. As part of a broader collaborative project with Mineral Resources Tasmania on the petroleum prospectivity of the Bass Basin, this geochemical study has yielded strong evidence that Paleocene–Eocene coals have sourced the oil and gas in the Yolla, Pelican and Cormorant accumulations in the Bass Basin.Potential oil-prone source rocks in the Bass Basin have Hydrogen Indices (HIs) greater than 300 mg HC/g TOC. The coals w
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20

Kelly, Kevin R., Daniel O. Persky, Daruka Mahadevan, et al. "Phase 1 Study Of Investigational Agent MLN8237 (Alisertib) + Rituximab ± Vincristine In Patients (Pts) With Relapsed/Refractory (Rel/Ref) Aggressive B-Cell Lymphomas." Blood 122, no. 21 (2013): 3027. http://dx.doi.org/10.1182/blood.v122.21.3027.3027.

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Abstract Background Amplification and/or over-expression of the mitotic Aurora A kinase (AAK) have been reported in a variety of tumors. The investigational, selective, AAK inhibitor MLN8237 (alisertib) has shown signs of anti-tumor activity in pts with hematologic malignancies including aggressive non-Hodgkin lymphoma (NHL). Over-expression of AAK leads to resistance to microtubule targeted agents such as vincristine (V) and inhibiting AAK leads to synergy in the presence of these agents (Mahadevan D et al. CCR 2012). The combination of MLN8237 (M) + rituximab (R) ± V has shown synthetic leth
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21

Lucas, David M., Ryan B. Edwards, Michael D. De Lay, et al. "The Plant-Derived Agent Silvestrol Has B-Cell Selective Activity In Vitro in Chronic Lymphocytic Leukemia Patient Cells and In Vivo in the Tcl-1 Mouse Model of CLL." Blood 110, no. 11 (2007): 3123. http://dx.doi.org/10.1182/blood.v110.11.3123.3123.

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Abstract Chronic Lymphocytic Leukemia (CLL) is an incurable disease with limited therapeutic options, especially for high-risk populations such as the del(17p13) patient subset. Currently available therapies for CLL, even if effective, can have significant detrimental effects on remaining T cells, leaving patients at risk of potentially lethal opportunistic infections. New agents with unique mechanisms of action, independence of key resistance pathways, and selectivity for tumor cells are crucial to make an impact on patient survival. Silvestrol, a structurally unique compound isolated from th
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22

Jain, Jugnu, Jianguo Ma, Brinley Furey, et al. "The IMPDH Inhibitor VX-944 Demonstrates In Vivo Efficacy in an Aggressive Leukemia Model." Blood 104, no. 11 (2004): 2530. http://dx.doi.org/10.1182/blood.v104.11.2530.2530.

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Abstract VX-944 is a small molecule, orally bioavailable, specific inhibitor of inosine monophosphate dehydrogenase (IMPDH), an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. We have previously shown that VX-944 has broad anti-cancer properties in vitro and that its potency is not affected by MDR pumps (Jain et al, Blood 2002, 100:572a; ibid 2003, 102: 622a). Here, we describe studies that demonstrate its oncolytic activity in blast cells derived from patients with acute myeloid leukemia (AML). We also report the efficacy of VX-944 in an aggressive murine model of myel
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23

Bonanni, B., B. Santillo, D. Serrano, et al. "The hormone replacement therapy opposed to low dose tamoxifen (HOT) study: safety data from an ongoing phase III trial." Journal of Clinical Oncology 25, no. 18_suppl (2007): 1514. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.1514.

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1514 Background: Primary prevention trials have shown that tamoxifen (T) lowers ER+ breast cancer (BC) incidence by 48%. While the IBIS I update showed mixed findings, the Italian trial showed an interesting positive risk/benefit ratio in T and hormone replacement therapy (HRT) users: fewer BC, endometrial cancer comparable to placebo, and no cardiovascular diseases (CVD) excess. In a phase II study, low dose T and HRT showed a safe gynecological profile and did not increase menopausal symptoms. Moreover low dose T maintains the same antiproliferative effects as the standard dose. To improve B
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24

Fontana, Vincenzo, Carlos J. Bidot, Wenche Jy, Eugene R. Ahn, Lawrence L. Horstman, and Yeon S. Ahn. "Hepatitis C Associated ITP: High Incidence of Autoantibodies Specific to Platelet Glycoproteins and Favorable Response to IL-11." Blood 106, no. 11 (2005): 1247. http://dx.doi.org/10.1182/blood.v106.11.1247.1247.

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Abstract BACKGROUND. ITP is an autoimmune disorder in which autoantibodies (Ab) reacting to platelet glycoproteins (Gp) mediate immune destruction of platelets. In most cases the cause is unknown, but chronic infections such as hepatitis C, studied here, are often associated with ITP (ITP-C). In ITP-C, it is not clear whether platelets are destroyed by viral immune complex or by Gp Ab, as in classic active ITP (ITP-A). Antiviral therapy may not induce remission in ITP-C, so its management remains problematic. We investigated Gp Ab in ITP-C vs. ITP-A, and evaluated efficacy of IL-11 in a group
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25

Merlini, Giampaolo, Vaishali Sanchorawala, Zonder A. Jeffrey, et al. "Long-Term Outcome of a Phase 1 Study of the Investigational Oral Proteasome Inhibitor (PI) Ixazomib at the Recommended Phase 3 Dose (RP3D) in Patients (Pts) with Relapsed or Refractory Systemic Light-Chain (AL) Amyloidosis (RRAL)." Blood 124, no. 21 (2014): 3450. http://dx.doi.org/10.1182/blood.v124.21.3450.3450.

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Abstract Background Systemic AL amyloidosis is a life-threatening disease with limited treatment options. Response criteria have been recently updated and retrospectively validated (Palladini et al, J Clin Oncol 2012). Hematologic response (suppression of FLCs) has been shown to predict for both organ response and survival (ibid). Preliminary results from the present phase 1 study (NCT01318902) regarding the safety, tolerability, and maximum tolerated dose (MTD) of ixazomib (the first oral PI to be investigated in the clinic) in RRAL were reported previously (Merlini et al, ASH 2012). At that
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26

Bruckner, Howard, Azriel Hirschfeld, Robert L. De Jager, et al. "Moderate dose serial therapy for aged and resistant patients with cholangiocarcinomas." Journal of Clinical Oncology 39, no. 15_suppl (2021): e16160-e16160. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e16160.

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e16160 Background: Advanced (Adv) intrahepatic IH Cholangiocarcinoma BD trials found multi-drug, sequences (GFLIO) safely expand eligibility (El) for patients (pts) of all ages -/+ resistant Ca (R). Two series had response/survival (S) of 80% / > 2 years (yr) (Bruckner et al Anti Ca Res 16). Therapy reverses R to key drugs, improves the pts' many immune functions and exposure to neoantigens, (Caraglia RT et al Front Oncol 19.) A.L.A.N.(AS) blood tests (Ts) predict chances of S (Salati et al EuJCa 18). Methods: Kaplan-Meier analyses examine prognostic Ts as El criteria for real-world pts. El
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27

Pereira, Luciana Felício, Marcel Auguste Dardenne, Carlos Alberto Rosière, and Antônio Carlos Pedrosa-Soares. "EVOLUÇÃO GEOLÓGICA DOS GRUPOS CANASTRA E IBIÁ NA REGIÃO ENTRE COROMANDEL E GUARDA-MOR, MG." Geonomos, July 1, 1994. http://dx.doi.org/10.18285/geonomos.v2i1.229.

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The stratigraphic column established for the Canastra Group, in the Alto Paranaíba region in the centralportion of the Brasília Fold Belt, represents a regressive megasequence of sediments deposited on an openseacontinental platform. The following units occur from base to top: a turbiditic sequence with arenaceousand argillaceous intercalations; an arenaceous sequence containing storm beds; and a clay-rich arenaceoussequence with structures reflecting shallow marine and tidal flat environments. The Ibiá Group overlies theCanastra Group on an erosional disconformity. Its base consists of a meta
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28

Andrade, Kerley Wanderson, and Mario Luiz de Sá Carneiro Chaves. "GEOLOGIA E A REDISTRIBUIÇÃO SEDIMENTAR PÓS-CRETÁCICA DOS DEPÓSITOS DIAMANTÍFEROS DA REGIÃO AO SUL DE COROMANDEL (MG)." Geonomos, February 15, 2013. http://dx.doi.org/10.18285/geonomos.v17i1.81.

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A região do Rio Douradinho ao sul de Coromandel apresenta períodos distintos em sua evoluçãotectônica. A fase mais antiga corresponde à sedimentação das tectonossequências meso e neoproterozóicasrepresentadas pelos grupos Canastra, Ibiá e Araxá. Essas unidades compreendem a Faixa de DobramentosBrasília, estruturada durante o Ciclo Brasiliano, estabelecendo seus contatos geológicos através de longasfalhas de empurrão e zonas de cisalhamento, com baixo grau metamórfico associado. Durante o “Soerguimentodo Alto Paranaíba”, no intervalo Jurássico – Cretáceo, reativaram-se antigas estruturas region
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29

Velasco, Roberto, Ainara Lejarzegi, Borja Gomez, et al. "Febrile young infants with abnormal urine dipstick at low risk of invasive bacterial infection." Archives of Disease in Childhood, November 27, 2020, archdischild—2020–320468. http://dx.doi.org/10.1136/archdischild-2020-320468.

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ObjectivesTo develop and validate a prediction rule to identify well-appearing febrile infants aged ≤90 days with an abnormal urine dipstick at low risk of invasive bacterial infections (IBIs, bacteraemia or bacterial meningitis).DesignAmbispective, multicentre study.SettingThe derivation set in a single paediatric emergency department (ED) between 2003 and 2017. The validation set in 21 European EDs between December 2017 and November 2019.PatientsTwo sets of well-appearing febrile infants aged ≤90 days with an abnormal urine dipstick (either leucocyte esterase and/or nitrite positive test).Ma
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30

Chen, Wei, Lingfei Jiang, Yueqiang Hu, et al. "Effects of Zhuyu Annao on Hippocampal Neuronal Apoptosis and Cognitive Disorder in a Rat Model of Ischemic Brain Injury." Archives of Medical Science, March 21, 2021. http://dx.doi.org/10.5114/aoms/132229.

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IntroductionWe aimed to determine the effects of Zhuyu Annao (ZYAN) prescription on hippocampal neuronal apoptosis and cognitive disorder (CD) in ischemic brain injury (IBI).Material and methodsThe improved Rice-Vannucci method was used to prepare a rat model of IBI. Rats in the ZYAN prescription group were intragastrically administered 12.50 g/kg of ZYAN prescription 4 h after modeling; rats in the mock surgical group (MSG) and model group (MG) were administered an intraperitoneal injection of the same volume of normal saline twice daily.ResultsCompared with MG, the area of cerebral infarctio
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Kimura, Claudia Bianca, Clodoaldo Rogério dos Reis, and Luiz Cláudio Fernandes. "EFEITO DO CONSUMO DE ÁGUA RICA EM SAIS DE VANÁDIO SOBRE A GLICEMIA DE RATOS DIABÉTICOS." Estudos de Biologia 28, no. 65 (2006). http://dx.doi.org/10.7213/reb.v28i65.22742.

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Diabetes mellitus é uma doença caracterizada principalmente por hiperglicemia crônica. Sua etiologia pode estar associada à produção insuficiente ou resistência à insulina. O desenvolvimento de terapias alternativas para a diabetes é muito importante. Vários compostos de vanádio vêm sendo indicados no tratamento para da diabetes, devido ao seu efeito mimético ao da insulina. Muitos pacientes afirmam melhora de seu estado diabético ao consumirem tal água. Este estudo investigou o efeito do consumo de água rica em vanádio, proveniente de Ibirá (SP), sobre a glicemia de ratos induzidos a diabetes
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