Relevant bibliographies by topics / Ibuprofen

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Ibuprofen'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Ibuprofen.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Ibuprofen"

1

Damayanti, Sophi, Slamet Ibrahim, Kurnia Firman, and Daryono H. Tjahjono. "SIMULTANEOUS DETERMINATION OF PARACETAMOL AND IBUPROFENE MIXTURES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY." Indonesian Journal of Chemistry 3, no. 1 (June 7, 2010): 9–13. http://dx.doi.org/10.22146/ijc.21899.

Full text
Abstract:
Analytical method for the determination of paracetamol and ibuprofene mixtures has been developed by High Performance Liquid Chromatography using C-18 column and acetinitrile - phosphate buffer pH = 4.5 (75:25) containing 0.075% sodium hexanesulfunate as a mobile phase. The detector was set at 215 nm. Using such conditions, retention time for paracetamol and ibuprofen was 4.89 and 7.11 min, respectively. The recovery for paracetamol and ibuprofen was found to be 101.07± 0.73% and 102.02 ± 1.58%, respectively. The detector limits of the method was 1.30 and 1.60 μg/mL with the relative standard deviation (RSD) 0.74 and 1.52% for paracetamol and ibuprofen, respectively. Keywords: paracetamol, ibuprofen, multi-component, validation, HPLC.
APA, Harvard, Vancouver, ISO, and other styles
2

D. Vaghela, Pooja, N. U. Patel, and H. M. Tank. "Preparation and Evaluation of Directly Compressible Tablets of Ibuprofen Crystals." Indo Global Journal of Pharmaceutical Sciences 12 (2022): 166–74. http://dx.doi.org/10.35652/igjps.2022.12019.

Full text
Abstract:
The goalof present studywas to prepare the directly compressible tablets of Ibuprofen crystals prepared by crystallization technique using saccharin sodium as an excipient. The prepared tabletswere evaluatedfor the improvement in drug release of Ibuprofenas compared to the pure drug. The crystal formation of Ibuprofen lead to improve the compressibility and mechanical strength of thedrug which can be easily converted to directlycompressible tablets. The In-vitro dissolution profiledemonstrates 3.96fold incrementin the drug release rate from tablets of Ibuprofen crystals compared to the pure drug after one hour. The characterization was done byPowder X-Ray Diffractometry (pXRD), and Headspace Gas Chromatography (HSGC) Study of Ibuprofen treated crystals illustrates the improvement in manufacturabilityand pharmacotechnical parameters of the drug.©2022iGlobal Research and PublishingFoundation. All rights reserved.
APA, Harvard, Vancouver, ISO, and other styles
3

Bastos, Joana C., Nicole S. M. Vieira, Maria Manuela Gaspar, Ana B. Pereiro, and João M. M. Araújo. "Human Cytotoxicity, Hemolytic Activity, Anti-Inflammatory Activity and Aqueous Solubility of Ibuprofen-Based Ionic Liquids." Sustainable Chemistry 3, no. 3 (August 13, 2022): 358–75. http://dx.doi.org/10.3390/suschem3030023.

Full text
Abstract:
Ionic liquids (ILs) are a potential solution to the general problem of low solubility, polymorphism and low bioavailability of active pharmaceutical ingredients (APIs). In this work, we report on the synthesis of three pharmaceutically active ILs (API-ILs) based on ibuprofen, one of the most commonly available over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs), with imidazolium cations ([C2C1Im][Ibu] and [C2(OH)C1Im][Ibu]) and a cholinium cation ([N1112(OH)][Ibu]). An upgrade to the aqueous solubility (water and biological simulated fluids) for the ibuprofen-based ILs relative to the ibuprofen’s neutral and salt form (sodium ibuprofen) was verified. The cytotoxic profiles of the synthesized API-ILs were characterized using two human cells lines, Caco-2 colon carcinoma cells and HepG-2 hepatocellular carcinoma cells, up to ibuprofen’s maximum plasma concentration (Cmax) without impairing their cytotoxicity response. Additionally, the EC50 in the Caco-2 cell line revealed similar results for both parent APIs and API-ILs. The biocompatibility of the ibuprofen-based ILs was also evaluated through a hemolytic activity assay, and the results showed that all the ILs were hemocompatible at concentrations higher than the ibuprofen Cmax. Moreover, the anti-inflammatory properties of the API-ILs were assessed through the inhibition of bovine serum albumin (BSA) denaturation and inhibition of cyclooxygenases (COX-1 and COX-2). The results showed that [C2C1Im][Ibu], [C2(OH)C1Im][Ibu] and [N1112(OH)][Ibu] maintained their anti-inflammatory response to ibuprofen, with improved selectivity towards COX-2, allowing the development of safer NSAIDs and the recognition of new avenues for selective COX-2 inhibitors in cancer chemotherapy and neurological diseases such as Alzheimer’s and Parkinson’s.
APA, Harvard, Vancouver, ISO, and other styles
4

Jan-Roblero, Janet, and Juan A. Cruz-Maya. "Ibuprofen: Toxicology and Biodegradation of an Emerging Contaminant." Molecules 28, no. 5 (February 23, 2023): 2097. http://dx.doi.org/10.3390/molecules28052097.

Full text
Abstract:
The anti-inflammatory drug ibuprofen is considered to be an emerging contaminant because of its presence in different environments (from water bodies to soils) at concentrations with adverse effects on aquatic organisms due to cytotoxic and genotoxic damage, high oxidative cell stress, and detrimental effects on growth, reproduction, and behavior. Because of its high human consumption rate and low environmental degradation rate, ibuprofen represents an emerging environmental problem. Ibuprofen enters the environment from different sources and accumulates in natural environmental matrices. The problem of drugs, particularly ibuprofen, as contaminants is complicated because few strategies consider them or apply successful technologies to remove them in a controlled and efficient manner. In several countries, ibuprofen’s entry into the environment is an unattended contamination problem. It is a concern for our environmental health system that requires more attention. Due to its physicochemical characteristics, ibuprofen degradation is difficult in the environment or by microorganisms. There are experimental studies that are currently focused on the problem of drugs as potential environmental contaminants. However, these studies are insufficient to address this ecological issue worldwide. This review focuses on deepening and updating the information concerning ibuprofen as a potential emerging environmental contaminant and the potential for using bacteria for its biodegradation as an alternative technology.
APA, Harvard, Vancouver, ISO, and other styles
5

&NA;. "Ibuprofen see Indomethacin/ibuprofen." Reactions Weekly &NA;, no. 304 (June 1990): 7. http://dx.doi.org/10.2165/00128415-199003040-00023.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Abbas Mayar Hezam. "Design of a bacterial system using Escherichia coli to detect the mutagenic effect of some drugs." Al-Qadisiyah Journal of Pure Science 27, no. 1 (February 15, 2023): 21–30. http://dx.doi.org/10.29350/qjps.2022.27.1.1604.

Full text
Abstract:
The current study aimed to use the auxotroph's tryptophan Escherichia coli as a test to detect Ibuprofen's mutagenic potential. the Ames test was used to detect reverse mutations in auxotroph's E. coli treated with Ibuprofen. The results showed a significant increase (P< 0.05) in reverse colonies of auxotroph's E. coli treated with 250 and 500 mg/mL of Ibuprofen compared to the negative control. The polymerase chain reaction and DNA Sequencing were used to detect the reverse mutations in the try gene of the auxotroph's E. coli. The results showed the presence of the try gene in all isolates treated with 250 and 500 mg/mL of Ibuprofen at a percentage of (100%). The try gene was sequenced using BLAST software and compared to the gene sequence of a standard isolate. The genetic variation analysis of the try gene isolates treated with Ibuprofen revealed that point mutations in the DNA of the try gene altered protein translation.
APA, Harvard, Vancouver, ISO, and other styles
7

Bedis, Smita, and Priydarshani Kamble. "Ibuprofen Nanoemulsion as a Promising Drug Delivery Strategy." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (June 30, 2022): 965–69. http://dx.doi.org/10.25258/ijddt.12.3.07.

Full text
Abstract:
Phenyl propionic acid derivative drug Ibuprofen was selected for the study’s model medication. It is hypothesized that nanoemulsion might be a useful medication delivery method for enhancing oral absorption. According to the findings, the nanoemulsion formulation greatly enhanced the drug’s anti-inflammatory capabilities when compared to the Ibuprofen solution. Ibuprofen’s solubility and oral bioavailability are enhanced using nanoemulsion technology. To evaluate and pinpoint nanoemulsion area’s are made of glycerol, olive oil, and various sucrose esters, a pseudo ternary phase diagram was created (co-surfactant). Following the discovery of such a nanoemulsion zone, a colloidal system was created to serve as an ibuprofen carrier system. Droplet size, polydispersity index, zeta potential, and morphological measurements were made to determine the characteristics of the chosen nanoemulsion (NE) area.
APA, Harvard, Vancouver, ISO, and other styles
8

Mahmood, Syed, Samah Hamed Almurisi, Khater AL-Japairai, Ayah Rebhi Hilles, Walla Alelwani, Azzah M. Bannunah, Farhan Alshammari, and Fawaz Alheibshy. "Ibuprofen-Loaded Chitosan–Lipid Nanoconjugate Hydrogel with Gum Arabic: Green Synthesis, Characterisation, In Vitro Kinetics Mechanistic Release Study and PGE2 Production Test." Gels 7, no. 4 (December 8, 2021): 254. http://dx.doi.org/10.3390/gels7040254.

Full text
Abstract:
Ibuprofen is a well-known non-steroidal anti-inflammatory (NSAID) medicine that is often used to treat inflammation in general. When given orally, it produces gastrointestinal issues which lead to lower patient compliance. Ibuprofen transdermal administration improves both patient compliance and the efficacy of the drug. Nanoconjugation hydrogels were proposed as a controlled transdermal delivery tool for ibuprofen. Six formulations were prepared using different compositions including chitosan, lipids, gum arabic, and polyvinyl alcohol, through ionic interaction, maturation, and freeze–thaw methods. The formulations were characterised by size, drug conjugation efficiency, differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). Further analysis of optimised hydrogels was performed, including X-ray diffraction (XRD), rheology, gel fraction and swelling ability, in vitro drug release, and in vitro macrophage prostaglandin E2 (PGE2) production testing. The effects of ibuprofen’s electrostatic interaction with a lipid or polymer on the physicochemical and dissolution characterisation of ibuprofen hydrogels were evaluated. The results showed that the S3 (with lipid conjugation) hydrogel provided higher conjugation efficiency and prolonged drug release compared with the S6 hydrogel.
APA, Harvard, Vancouver, ISO, and other styles
9

&NA;. "Ibuprofen see Ampicillin/aspirin/ibuprofen." Reactions Weekly &NA;, no. 334 (January 1991): 8. http://dx.doi.org/10.2165/00128415-199103340-00046.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Stock, K. P., G. Geisslinger, D. Loew, W. S. Beck, G. L. Bach, and K. Brune. "S-Ibuprofen versus ibuprofen-racemate." Rheumatology International 11, no. 4-5 (November 1991): 199–202. http://dx.doi.org/10.1007/bf00332562.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Ibuprofen"

1

Peres, Fernanda de Oliveira. "Estudo da dissociação de ibuprofeno utilizando matrizes de quitosana e montmorilonita/quitosana." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-02072014-110954/.

Full text
Abstract:
A quitosana tem se mostrado muito atrativa para a indústria farmacêutica, visando principalmente matrizes de liberação controlada com fármacos amplamente utilizados pela população em altas dosagens ou em períodos prolongada tal como o Ibuprofeno. O uso de combinado de polímeros e materiais como a argila é uma opção interessante, unindo as propriedades de ambos os materiais, minimizando o efeito colateral do fármaco. No presente trabalho descreve-se a preparação de um complexo iônico contendo quitosana e ibuprofeno por meio de uma reação ácido base entre ambos. Em uma segunda etapa, foi preparado um nanocompósito de montmorilonita/quitosana contendo o fármaco ibuprofeno. As matrizes foram caracterizadas por diferentes técnicas, incluindo análise elementar, ressonância magnética nuclear (RMN) de 13C e 1H, termogravimetria (TG), calorimetria exploratória diferencial (DSC), difração de raios X (DRX) e espectroscopia de infravermelho com transformada de Fourrier (FTIR). O grau de desacetilação (GD) da quitosana obtido por titulação potenciométrica foi de 80,0%. Esses resultados foram confirmados por medidas de RMN 1H e RMN 13C. O estudo dissociação do fármaco, na presença e na ausência de argila, foi avaliado por cromatografia líquida de alta eficiência (CLAE) e por espectroscopia de absorção eletrônica UV-VIS. A dissociação do fármaco em meio aquoso foi avaliada em pH 2 e 7, que correspondem aos valores encontrados no estômago e no intestino, respectivamente. Os resultados indicaram que a dissociação do ibuprofeno das matrizes é dependente do pH e que a presença da argila retarda a dissociação do fármaco na matriz.
Due to its interesting properties chitosan has attracted interest regarding several applications including drug carrier in pharmaceutical industry, mainly for actives consumed in high doses for long periods, as Ibuprofen. The combined use of materials such as polymers and the clay is an interesting option, combining the properties of both materials while minimizing the side effects of the drug. A chitosan-ibuprofen ionic complex had been prepared from the acid-base reaction between both of them. In a second step a montmorilonite/chitosan nanocomposite containing ibuprofen was also prepared. The complex and the nacomposite containing ibuprofen had been characterized by several techniques including elemental analysis, 13C e 1H, nuclear magnetic resonance (NMR), thermogravimetry (TG), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and Fourrier transform infrared spectroscopy (FTIR). The chitosan degree of deacetylation (DD) was determined by potentiometry as 80.0%. These results were confirmed by 13C e 1H NMR. The dissociation of the pharmaceutical from the complex and nanocomposite was investigated by high performance liquid chromatography (HPLC) and electronic spectroscopy in the UV-vis (UV-vis). The dissociation of the pharmaceutical from the complex in aqueous media was evaluated in pH 2 and 7, corresponding to the stomach and intestines respectively. Results revealed that such dissociation is dependent of the pH of the medium as well as that release of Ibuprofen from the matrices is dependent on the pH and the presence of the clay slows the dissociation of the drug from the matrix.
APA, Harvard, Vancouver, ISO, and other styles
2

Ferraz, Humberto Gomes. "Comprimidos de ibuprofeno: formulação e avaliação do perfil de dissolução." Universidade de São Paulo, 1993. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-11112008-151322/.

Full text
Abstract:
O ibuprofeno é um anti-inflamatório não-esteroidal (AINE) que possui propriedades analgésicas e anti-térmicas e é empregado na terapêutica em casos dores discretas e moderadas, artrite reumatóide, osteoartrite e dismenorréia primária, nas concentrações de 200, 300, 400 e 600 mg. Entretanto, a formulação contendo 200 mg não está disponível no mercado farmacêutico brasileiro. No presente trabalho, foi desenvolvida uma formulação de comprimidos de ibuprofeno 200 mg que apresentou, além de outras características físico-químicas adequadas, um ótimo perfil de dissolução. Foram testadas oito formulações, obtidas a partir de um projeto fatorial fracionado, avaliando-se diversos excipientes. Além disto, as formulações foram submetidas à temperatura ambiente, 37 ºC e 50 ºC, e analisadas à 30 e 60 dias, com o objetivo de avaliar as transformações físicas que podem ocorrer durante o armazenamento das mesmas. Os resultados das análises físico-químicas foram tratados estatisticamente, utilizando-se o programa STATGRAFCS, através de uma análise exploratória e de um estudo de efeitos. Concluiu-se, então, que a melhor formulação foi a seguinte: IBUPROFENO - 200; AMIDO - 47; LACTOSE - 72; CELULOSE MICROCRISTALINA - 23; ESTEARATO DE MAGNESIO - 8.
Ibuprofen is a non steroidal antiinflamatory drug (NSAD), that has analgesic and antipyretic properties. It is used in terapeutic cases of mild to moderant pain, rheumatoid arthritis, osteoarthritis, and primary dysmenorrhea, in the 200, 300, 400, and 600 mg of concentration. In the Brazilian pharmaceutical market the formulation of 200 mg doesn\'t exist. In this study, a formulation of ibuprofen was developed for 200 mg tablets, that has suitable physical-chemical properties and an excellent dissolution profile. The eight formulations tested were obtained from factorial designs, evaluating several excipients. These formulations also had been submitted at room temperature, 37 ºC, and 50 ºC and were analised at 30 and 60 days, with the objective to evaluate the physical transformatiom that could have occurred during that time. The results were tested statistically by the STATGRAFCS program, using the exploratory analysis and the effects study. The final results showed that the best formulation was: IBUPROFEN - 200; STARCH - 47; LACTOSE - 72; MICROCRYSTALLINE CELLULOSE - 23; MAGNESIUM STEARATE - 8.
APA, Harvard, Vancouver, ISO, and other styles
3

Vasconcelos, Teófilo Cardoso de. "Solid Dispersions Containing Ibuprofen." Master's thesis, Faculdade de Farmácia da Universidade do Porto, 2007. http://hdl.handle.net/10216/7595.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Vasconcelos, Teófilo Cardoso de. "Solid Dispersions Containing Ibuprofen." Dissertação, Faculdade de Farmácia da Universidade do Porto, 2007. http://hdl.handle.net/10216/7595.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Wells, Larry Kevin. "Efficacy of Ibuprofen and Ibuprofen/Acetaminophen on Postoperative Pain in Symptomatic Necrotic Teeth." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1283354429.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Ribeiro, Paulo Jose Fernandes. "Desenvolvimento de um sensor potenciometrico para ibuprofeno." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248412.

Full text
Abstract:
Orientadores: Lauro Tatsuo Kubota, Graciliano de Oliveira Neto
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Quimica
Made available in DSpace on 2018-08-08T00:59:06Z (GMT). No. of bitstreams: 1 Ribeiro_PauloJoseFernandes_M.pdf: 3526765 bytes, checksum: d7527897c70e194a6207d1020f2ce8bc (MD5) Previous issue date: 2006
Resumo: Nesse trabalho é apresentado o desenvolvimento de um eletrodo íon-seletivo para determinação de ibuprofeno, utilizando-se membrana do copolímero poli(etileno co-acetato de vinila) (EVA), tentando minimizar o uso de plastificantes. A membrana foi preparada diretamente sobre um suporte condutor constituído de uma mistura de resina epóxi, endurecedor e grafite. Na preparação da membrana foram estudadas diversas proporções de seus componentes, como concentração de par-iônico, influência do plastificante e quantidades de matriz polimérica. As melhores respostas foram obtidas com uma membrana composta de 115 mg do par-iônico aliquat-ibuprofeno, 170 mg de EVA e 150 mg do plastificante o-NPOE (orto-nitrofeniloctil-éter), não sendo possível eliminar o plastificante. Com o objetivo de otimizar as condições analíticas, foram feitos estudos da influência do pH, da natureza e concentração do tampão e de interferentes, além do tempo de reposta e de vida do eletrodo. As melhores respostas em estado estacionário foram obtidas em tampão Fosfato com concentração de 0,5 mol L a pH 7.0. Nestas condições foi verificado um bom desempenho do eletrodo na faixa de concentração de 2,93 10 a 10mol L, com limite de detecção de 8,7 10 mol L, sensibilidade de 127 mV década, tempo médio de resposta de 56 s e capacidade para aproximadamente 100 determinações. O eletrodo foi aplicado para determinação de ibuprofeno em amostras de medicamento obtendo bons resultados, sendo estes estatisticamente igual aos obtidos com o método de referência a um nível de 95% de confiança.
Abstract: In this work is presented the development of an ion-selective electrode for ibuprofen determination, using the poly(ethylene-co-vinyl-acetate) copolymer (EVA) membrane, trying to minimize the use of plasticizer. The membrane was prepared directly on a conducting support consisting of an epóxi resin, hardener and graphite mixture. In the preparation of the membrane several ratios of its components were investigated, such as concentration of ion-pair, influence of the plasticizer and polymeric matrix. The best performance was reached with a membrane composed with 115 mg of the ibuprofen-aliquat ion-pair, 170 mg of EVA and 150 mg of the o-NPOE (orto-nitrophenyloctyl-ether), being impossible to eliminate the plasticizer. Studies of the influence of pH, nature and concentration of the buffer and the interfering were carried out looking for the optimized conditions for the electrode performance like sensitivity, fast response and lifetime. The best response was obtained with Phosphate buffer in a concentration of 0,5 mol L at pH 7.0. In these conditions the electrode showed a good performance in the concentration range between 2,93 10 and 10 mol L, with a sensitivity of 127 mV/decade, a detection limit of 8,7 10 mol L, response time of 56 s and capacity for 100 determinations. The electrode was employed to determine ibuprofen in medicine samples obtaining good results, being statistically equal at 95% confidence level, when compared with the results obtained with the reference method for the same samples.
Mestrado
Quimica Analitica
Mestre em Química
APA, Harvard, Vancouver, ISO, and other styles
7

Nokhodchi, Ali. "The compaction properties of hydroxypropylmethylcellulose and ibuprofen." Thesis, Liverpool John Moores University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319846.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Pereira, Anna Karla dos Santos. "Síntese de nanopartículas de prata suportadas em microesferas e filmes de quitosana: estudo da atividade antibacteriana e aplicação na liberação controlada de ibuprofeno." Universidade Federal do Tocantins, 2017. http://hdl.handle.net/11612/496.

Full text
Abstract:
Desde a década de 90 que estudos relacionados com os polímeros quitina e quitosana têm sido estimulados. A presença em maior quantidade de grupos NH2 na quitosana permite sua aplicação como biomaterial eficiente no carreamento de fármacos e na adsorção de cátions metálicos. Neste trabalho foram preparados filmes e microesferas de quitosana para uso em procedimentos de adsorção de íons prata, liberação de fármaco e atividade antibacteriana. O polímero apresentou grau de desacetilação correspondente a 81% e ponto de carga zero em pH~7. As microesferas obtidas apresentaram um diâmetro médio de 2,911 mm e um desvio padrão de 0,325, quando úmidas. O uso da quitosana na forma de microesferas e filmes proporciona um aumento da área superficial, além de facilitar o manuseio do polímero. Os filmes obtidos foram formados com nanopartículas de prata em etapa única. O melhor pH para o estudo de adsorção de íons Ag+ em meio aquoso está na faixa de pH de 5 a 7, o melhor ajuste foi ao modelo de Langmuir, o tempo ótimo para ocorrer adsorção máxima foi de 10 horas e o valor de energia aparente de adsorção (E) de 6,9 kJ/mol, o que a caracteriza adsorção física. O estudo de liberação de ibuprofeno foi realizado em fluido gástrico simulado e fluido intestinal simulado, a maior liberação do fármaco ocorreu no pH neutro dos fluidos intestinais. A liberação transdérmica de fármaco pelos filmes foi realizada apenas em pH=7,4 para simular o tecido sanguíneo e o ápice da liberação de ibuprofeno ocorreu logo no início do contato do material com o fluido simulado. As microesferas e os filmes com nanopartículas de prata demonstram ter atividade contra E. coli e S. aureus.
Since the 1990s studies related to chitin and chitosan polymers have been stimulated. The presence of more NH2 groups in chitosan allows its application as an efficient biomaterial without drug loading and adsorption of metallic cations. In this work, chitosan films and microspheres were made for use in silver ion adsorption procedures, drug release and antibacterial activity. The polymer showed a degree of deacetylation corresponding to 81% and zero loading point at pH ~ 7. As obtained microspheres had a mean diameter of 2911 mm and a standard deviation of 0.325, when used. The use of chitosan in the form of microspheres and films provides an increase of the surface area, besides facilitating the handling of the polymer. The films were formed with single step silver nanoparticles. The best pH for the Ag+ ion adsorption study in the aqueous medium is in the pH range of 5 to 7, the best fit for the Langmuir model, the optimal time for the maximum adsorption of 10 hours and the apparent energy value of adsorption (E) of 6,9 kJ / mol, which characterizes it physical adsorption. The study of ibuprofen release was performed in simulated gastric fluid and simulated intestinal fluid, further release of the drug occurs no neutral pH of intestinal fluids. Transdermal delivery of drug by films was performed at pH = 7.4 to simulate blood tissue and the apex of ibuprofen release occurred early in contact with the simulated fluid material. As microspheres and films with silver nanoparticles they demonstrate activity against E. coli and S. aureus.
APA, Harvard, Vancouver, ISO, and other styles
9

Ho, Loi. "Determination of Ibuprofen Isotherm Using Supercritical Fluid Chromatography." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4075.

Full text
Abstract:
Chromatography is widely used to determine physiochemical properties data including adsorption isotherm. In the separation of enantiomers through sorptive processes, supercritical fluids allow efficient and green alternatives to liquid solvent based systems. The isotherm information is vital in the development of operating policies and design of preparative chromatographic or moving bed separation schemes. Determination of sorption isotherms from experimental chromatographic elution data is automated and compared with different chromatogram model. Procedures were developed and validated for separation of R- and S- ibuprofen with supercritical 〖CO〗_2 and ethanol mixture as the mobile phase over a chiral stationary phase. The isotherms for the Langmuir, Freundlich, and Toth gave the similar results with a small residual for S-Ibuprofen at 150 bars and 40℃. Relative small amount of sample can be use from experiments to determine isotherms data that later be use for scale-up of the sorptive processes in industry to reduce time and cost.
APA, Harvard, Vancouver, ISO, and other styles
10

Patel, Nikunjkumar Valjibhai. "Metabolism of ibuprofen : synthetic, stereochemical and bioanalytical studies." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432460.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Ibuprofen"

1

Rainsford, K. D., ed. Ibuprofen. Abingdon, UK: Taylor & Francis, 1999. http://dx.doi.org/10.4324/9780203362587.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Rainsford, K. D., ed. Ibuprofen. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118743614.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Ibuprofen: Discovery, development and therapeutics. Chichester, West Sussex: John Wiley and Sons, Inc., 2015.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Rainsford, K. D. Ibuprofen: Pharmacology, Therapeutics and Side Effects. Basel: Springer Basel, 2012. http://dx.doi.org/10.1007/978-3-0348-0496-7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Ogle, Barbara Gobis. The pharmacokinetics and pharmacodynamics of ibuprofen enantiomers in osteoarthritis. [Toronto, Ont: Faculty of Pharmacy, University of Toronto, 1990.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Parker, Philip M., and James N. Parker. Motrin: A medical dictionary, bibliography, and annotated research guide to Internet references. San Diego, CA: ICON Health Publications, 2004.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Ron, Akehurst, and Sheffield Centre for Health and Related Research., eds. An Economic evaluation of Nabumetone/Relifex compared with Ibuprofen and a weighted NSAID combination. Sheffield: Sheffield Centre for Health and Related Research, University of Sheffield, 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Scott, C. J. Investigation of the particle size distribution of ibuprofen in both solid and suspension formswith the Galai Computerised Inspection System. Wolverhampton: University of Wolverhampton, 1994.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Aliza, Holtz, and Procter & Gamble Company., eds. Advances in the management of acute pain: Proceedings of a symposium sponsored by Procter & Gamble Company, Monterrey, Mexico, March 1996. London: Royal Society of Medicine Press, 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Leod, Peterson. Ibuprofen. Independently Published, 2019.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Ibuprofen"

1

Rainsford, K. D. "Appendix A Some Proprietary Brands and Preparations of Ibuprofen Available Worldwide." In Ibuprofen, 571–80. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118743614.app1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Rainsford, K. D. "Appendix B References to Analytical Methods for Determination of Ibuprofen in Biological Fluids, Principally Plasma." In Ibuprofen, 581–87. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118743614.app2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Rainsford, K. D. "History and Development of Ibuprofen." In Ibuprofen, 1–21. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118743614.ch1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Rainsford, K. D. "Hepatorenal Effects of Ibuprofen Compared with other NSAIDs and Paracetamol." In Ibuprofen, 430–49. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118743614.ch10.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Miwa, L. J., M. Maneno, and Judith K. Jones. "Adverse Drug Reactions Attributed to Ibuprofen." In Ibuprofen, 450–97. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118743614.ch11.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Volans, Glyn. "Human Toxicity of Ibuprofen." In Ibuprofen, 498–517. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118743614.ch12.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Harris, Randall E. "Ibuprofen in the Prevention and Therapy of Cancer." In Ibuprofen, 518–46. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118743614.ch13.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Rainsford, K. D. "Ibuprofen in Prevention of Neurodegenerative Diseases." In Ibuprofen, 547–70. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118743614.ch14.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Nichol, Kenneth J., and David W. Allen. "The Medicinal Chemistry of Ibuprofen." In Ibuprofen, 22–50. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118743614.ch2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Higton, Fred. "The Pharmaceutics of Ibuprofen." In Ibuprofen, 51–80. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118743614.ch3.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Ibuprofen"

1

Putri, Ulfa Rahmawati, Dwi Siswanta, Dadan Hermawan, and Mudasir Mudasir. "Molecular Docking Approach for Prediction of Enantioseparation of Chiral Ibuprofen by α-1-Acid Glycoprotein Column." In Life Science, Materials and Applied Chemistry. Switzerland: Trans Tech Publications Ltd, 2022. http://dx.doi.org/10.4028/p-ox63hg.

Full text
Abstract:
A study of the molecular anchoring and inclusion complex of the R/S-ibuprofen chiral compound with α-1-acid glycoprotein (AGP) has been carried out. This study aimed to predict the chiral separation of ibuprofen using chiral column filled with AGP protein. The geometrical optimization of R/S-ibuprofen was conducted on different calculation methods to obtain the optimal molecular structure. Molecular docking approaches, specifically docking using AutodockTools software were used to predict R/S-ibuprofen separation in AGP chiral column by comparing the binding energy values and the type of interaction. Results of the study show that the best method for optimizing the geometry of ibuprofen is Density Functional Theory (DFT). Furthermore, the results of the specific anchoring of ibuprofen on the AGP shows that the binding energy of S-ibuprofen with AGP is more negative than that of R-ibuprofen, namely -5.63 and -5.55 kcal/mol, respectively, indicating that S-ibuprofen interacts more strongly with AGP and therefore it will be eluted from the AGP chiral column later after R-ibuprofen.
APA, Harvard, Vancouver, ISO, and other styles
2

Maiti, Siddhartha, Jorge L. Jimenez-Rios, and Sankha Bhowmick. "Ibuprofen Release From Electrospun Nanofibers." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53447.

Full text
Abstract:
Controlled and gradual drug delivery is important in order to improve therapeutic efficiency and to reduce potential toxic effects due to overdose of the particular drug. Electrospun nanofibres have gained much attention for controlled drug delivery as the electrospinning process produces scaffolds with very high surface to volume ratio, while being a very simple and cost-effective process. A wide variety of drugs can be effectively incorporated into the fibers, and the structure and function of the fibers and the drug has been found to be maintained (1, 2).
APA, Harvard, Vancouver, ISO, and other styles
3

Pant, Bhasker, Sheetal Mujoo, Shaikh Rajesh Ali, Vasu Gajendiran, Larissa Souza Amaral, and Mohammad Mobarak Hossain. "Smart Mesoporous Silica Nanocomposite for Triggered and Targeted Ibuprofen Drug Delivery." In International Conference on Recent Advancements in Biomedical Engineering. Switzerland: Trans Tech Publications Ltd, 2022. http://dx.doi.org/10.4028/p-hx82v3.

Full text
Abstract:
Mesoporous silica nanocomposite (MSNC) with a wall thick of around 10 nm were created using Fe3O4 nanoparticles as the inorganic template. In accordance with the results of SEM and BET analysis, MSNC were homogenous spherical particles with good dispersion, and their specific surface area it possible that Ibuprofen will become stuck within the MSNC carrier. Loading of drug shows a decline in a surface area from 225.08 to 69.25 m2 g-1, pore volume from 0.56 to 0.13cm g-1 and the pore diameter from 7.96 to 6.74 nm correspondingly. The amount of Ibuprofen entrapped in the carrier was measured by UV spectroscopy and total glycerol (TG) measurement, respectively. It was determined pore size distribution of MSNC changed before and after Ibuprofen entrapment. The release profile of Ibuprofen from MSNC was characterised by a three-stage pattern with an influence on the time between each stage.
APA, Harvard, Vancouver, ISO, and other styles
4

Kim, Tae Hyun, Jae-Hyeon Ko, Haruki Takayama, Tomohiko Shibata, and Seiji Kojima. "Glass transition dynamics of enantiomer (+)-ibuprofen." In 4TH INTERNATIONAL SYMPOSIUM ON SLOW DYNAMICS IN COMPLEX SYSTEMS: Keep Going Tohoku. American Institute of Physics, 2013. http://dx.doi.org/10.1063/1.4794590.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Mitra, Siddhartha, Beau Benfield, and Beau Benfield. "SORPTION OF IBUPROFEN TO COASTAL PLAIN SOILS." In GSA Annual Meeting in Seattle, Washington, USA - 2017. Geological Society of America, 2017. http://dx.doi.org/10.1130/abs/2017am-305208.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Zinn, Sabrina, Melanie Schnell, and Thomas Betz. "CONFORMATIONAL ANALYSIS OF IBUPROFEN USING BROADBAND MICROWAVE SPECTROSCOPY." In 69th International Symposium on Molecular Spectroscopy. Urbana, Illinois: University of Illinois at Urbana-Champaign, 2014. http://dx.doi.org/10.15278/isms.2014.fd05.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Bharti, Shivani, Shikshita Jain, Gurvir Kaur, Shikha Gupta, and S. K. Tripathi. "pH dependent conjugation of Ibuprofen to PEGylated nanoparticles." In DAE SOLID STATE PHYSICS SYMPOSIUM 2017. Author(s), 2018. http://dx.doi.org/10.1063/1.5028723.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

BURTSEV, Vasilii, Elena MILIUTINA, Mariia ERZINA, Vaclav ŠVORCÍK, and Oleksiy LYUTAKOV. "SENSITIVE MICROMIXER FOR DETECTING LOW CONCENTRATIONS OF IBUPROFEN." In NANOCON 2019. TANGER Ltd., 2020. http://dx.doi.org/10.37904/nanocon.2019.8624.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Musiał, Joanna, Rafał Krakowiak, Dariusz Młynarczyk, Robert Frankowski, Agnieszka Zgoła-Grześkowiak, Tomasz Gośliński, and Beata Stanisz. "Photodegradation of Ibuprofen Using Phthalocyanine–Grafted Titanium Dioxide Nanoparticles." In 1st International Electronic Conference on Catalysis Sciences. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/eccs2020-07614.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Sharma, Sudhir Kumar, and Ramesh Jagannathan. "Synthesis of high throughput ibuprofen nanoparticles via supercritical CO2 processing." In 2019 IEEE 19th International Conference on Nanotechnology (IEEE-NANO). IEEE, 2019. http://dx.doi.org/10.1109/nano46743.2019.8993945.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Ibuprofen"

1

Calonico, Sebastian, Rafael Di Tella, and Juan Cruz Lopez Del Valle. Causal Inference During a Pandemic: Evidence on the Effectiveness of Nebulized Ibuprofen as an Unproven Treatment for COVID-19 in Argentina. Cambridge, MA: National Bureau of Economic Research, May 2022. http://dx.doi.org/10.3386/w30084.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Halker Singh, Rashmi B., Juliana H. VanderPluym, Allison S. Morrow, Meritxell Urtecho, Tarek Nayfeh, Victor D. Torres Roldan, Magdoleen H. Farah, et al. Acute Treatments for Episodic Migraine. Agency for Healthcare Research and Quality (AHRQ), December 2020. http://dx.doi.org/10.23970/ahrqepccer239.

Full text
Abstract:
Objectives. To evaluate the effectiveness and comparative effectiveness of pharmacologic and nonpharmacologic therapies for the acute treatment of episodic migraine in adults. Data sources. MEDLINE®, Embase®, Cochrane Central Registrar of Controlled Trials, Cochrane Database of Systematic Reviews, PsycINFO®, Scopus, and various grey literature sources from database inception to July 24, 2020. Comparative effectiveness evidence about triptans and nonsteroidal anti-inflammatory drugs (NSAIDs) was extracted from existing systematic reviews. Review methods. We included randomized controlled trials (RCTs) and comparative observational studies that enrolled adults who received an intervention to acutely treat episodic migraine. Pairs of independent reviewers selected and appraised studies. Results. Data on triptans were derived from 186 RCTs summarized in nine systematic reviews (101,276 patients; most studied was sumatriptan, followed by zolmitriptan, eletriptan, naratriptan, almotriptan, rizatriptan, and frovatriptan). Compared with placebo, triptans resolved pain at 2 hours and 1 day, and increased the risk of mild and transient adverse events (high strength of the body of evidence [SOE]). Data on NSAIDs were derived from five systematic reviews (13,214 patients; most studied was ibuprofen, followed by diclofenac and ketorolac). Compared with placebo, NSAIDs probably resolved pain at 2 hours and 1 day, and increased the risk of mild and transient adverse events (moderate SOE). For other interventions, we included 135 RCTs and 6 comparative observational studies (37,653 patients). Compared with placebo, antiemetics (low SOE), dihydroergotamine (moderate to high SOE), ergotamine plus caffeine (moderate SOE), and acetaminophen (moderate SOE) reduced acute pain. Opioids were evaluated in 15 studies (2,208 patients).Butorphanol, meperidine, morphine, hydromorphone, and tramadol in combination with acetaminophen may reduce pain at 2 hours and 1 day, compared with placebo (low SOE). Some opioids may be less effective than some antiemetics or dexamethasone (low SOE). No studies evaluated instruments for predicting risk of opioid misuse, opioid use disorder, or overdose, or evaluated risk mitigation strategies to be used when prescribing opioids for the acute treatment of episodic migraine. Calcitonin gene-related peptide (CGRP) receptor antagonists improved headache relief at 2 hours and increased the likelihood of being headache-free at 2 hours, at 1 day, and at 1 week (low to high SOE). Lasmiditan (the first approved 5-HT1F receptor agonist) restored function at 2 hours and resolved pain at 2 hours, 1 day, and 1 week (moderate to high SOE). Sparse and low SOE suggested possible effectiveness of dexamethasone, dipyrone, magnesium sulfate, and octreotide. Compared with placebo, several nonpharmacologic treatments may improve various measures of pain, including remote electrical neuromodulation (moderate SOE), magnetic stimulation (low SOE), acupuncture (low SOE), chamomile oil (low SOE), external trigeminal nerve stimulation (low SOE), and eye movement desensitization re-processing (low SOE). However, these interventions, including the noninvasive neuromodulation devices, have been evaluated only by single or very few trials. Conclusions. A number of acute treatments for episodic migraine exist with varying degrees of evidence for effectiveness and harms. Use of triptans, NSAIDs, antiemetics, dihydroergotamine, CGRP antagonists, and lasmiditan is associated with improved pain and function. The evidence base for many other interventions for acute treatment, including opioids, remains limited.
APA, Harvard, Vancouver, ISO, and other styles
3

Oral ibuprofen may be an option for closing patent ductus arteriosus in premature babies. National Institute for Health Research, July 2018. http://dx.doi.org/10.3310/signal-000611.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Ibuprofen' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography