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Journal articles on the topic 'Ibuprofen'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 March 2023

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1

Damayanti, Sophi, Slamet Ibrahim, Kurnia Firman, and Daryono H. Tjahjono. "SIMULTANEOUS DETERMINATION OF PARACETAMOL AND IBUPROFENE MIXTURES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY." Indonesian Journal of Chemistry 3, no. 1 (June 7, 2010): 9–13. http://dx.doi.org/10.22146/ijc.21899.

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Analytical method for the determination of paracetamol and ibuprofene mixtures has been developed by High Performance Liquid Chromatography using C-18 column and acetinitrile - phosphate buffer pH = 4.5 (75:25) containing 0.075% sodium hexanesulfunate as a mobile phase. The detector was set at 215 nm. Using such conditions, retention time for paracetamol and ibuprofen was 4.89 and 7.11 min, respectively. The recovery for paracetamol and ibuprofen was found to be 101.07± 0.73% and 102.02 ± 1.58%, respectively. The detector limits of the method was 1.30 and 1.60 μg/mL with the relative standard deviation (RSD) 0.74 and 1.52% for paracetamol and ibuprofen, respectively. Keywords: paracetamol, ibuprofen, multi-component, validation, HPLC.

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2

D. Vaghela, Pooja, N. U. Patel, and H. M. Tank. "Preparation and Evaluation of Directly Compressible Tablets of Ibuprofen Crystals." Indo Global Journal of Pharmaceutical Sciences 12 (2022): 166–74. http://dx.doi.org/10.35652/igjps.2022.12019.

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The goalof present studywas to prepare the directly compressible tablets of Ibuprofen crystals prepared by crystallization technique using saccharin sodium as an excipient. The prepared tabletswere evaluatedfor the improvement in drug release of Ibuprofenas compared to the pure drug. The crystal formation of Ibuprofen lead to improve the compressibility and mechanical strength of thedrug which can be easily converted to directlycompressible tablets. The In-vitro dissolution profiledemonstrates 3.96fold incrementin the drug release rate from tablets of Ibuprofen crystals compared to the pure drug after one hour. The characterization was done byPowder X-Ray Diffractometry (pXRD), and Headspace Gas Chromatography (HSGC) Study of Ibuprofen treated crystals illustrates the improvement in manufacturabilityand pharmacotechnical parameters of the drug.©2022iGlobal Research and PublishingFoundation. All rights reserved.

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3

Bastos, Joana C., Nicole S. M. Vieira, Maria Manuela Gaspar, Ana B. Pereiro, and João M. M. Araújo. "Human Cytotoxicity, Hemolytic Activity, Anti-Inflammatory Activity and Aqueous Solubility of Ibuprofen-Based Ionic Liquids." Sustainable Chemistry 3, no. 3 (August 13, 2022): 358–75. http://dx.doi.org/10.3390/suschem3030023.

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Ionic liquids (ILs) are a potential solution to the general problem of low solubility, polymorphism and low bioavailability of active pharmaceutical ingredients (APIs). In this work, we report on the synthesis of three pharmaceutically active ILs (API-ILs) based on ibuprofen, one of the most commonly available over-the-counter nonsteroidal anti-inflammatory drugs (NSAIDs), with imidazolium cations ([C2C1Im][Ibu] and [C2(OH)C1Im][Ibu]) and a cholinium cation ([N1112(OH)][Ibu]). An upgrade to the aqueous solubility (water and biological simulated fluids) for the ibuprofen-based ILs relative to the ibuprofen’s neutral and salt form (sodium ibuprofen) was verified. The cytotoxic profiles of the synthesized API-ILs were characterized using two human cells lines, Caco-2 colon carcinoma cells and HepG-2 hepatocellular carcinoma cells, up to ibuprofen’s maximum plasma concentration (Cmax) without impairing their cytotoxicity response. Additionally, the EC50 in the Caco-2 cell line revealed similar results for both parent APIs and API-ILs. The biocompatibility of the ibuprofen-based ILs was also evaluated through a hemolytic activity assay, and the results showed that all the ILs were hemocompatible at concentrations higher than the ibuprofen Cmax. Moreover, the anti-inflammatory properties of the API-ILs were assessed through the inhibition of bovine serum albumin (BSA) denaturation and inhibition of cyclooxygenases (COX-1 and COX-2). The results showed that [C2C1Im][Ibu], [C2(OH)C1Im][Ibu] and [N1112(OH)][Ibu] maintained their anti-inflammatory response to ibuprofen, with improved selectivity towards COX-2, allowing the development of safer NSAIDs and the recognition of new avenues for selective COX-2 inhibitors in cancer chemotherapy and neurological diseases such as Alzheimer’s and Parkinson’s.

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4

Jan-Roblero, Janet, and Juan A. Cruz-Maya. "Ibuprofen: Toxicology and Biodegradation of an Emerging Contaminant." Molecules 28, no. 5 (February 23, 2023): 2097. http://dx.doi.org/10.3390/molecules28052097.

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The anti-inflammatory drug ibuprofen is considered to be an emerging contaminant because of its presence in different environments (from water bodies to soils) at concentrations with adverse effects on aquatic organisms due to cytotoxic and genotoxic damage, high oxidative cell stress, and detrimental effects on growth, reproduction, and behavior. Because of its high human consumption rate and low environmental degradation rate, ibuprofen represents an emerging environmental problem. Ibuprofen enters the environment from different sources and accumulates in natural environmental matrices. The problem of drugs, particularly ibuprofen, as contaminants is complicated because few strategies consider them or apply successful technologies to remove them in a controlled and efficient manner. In several countries, ibuprofen’s entry into the environment is an unattended contamination problem. It is a concern for our environmental health system that requires more attention. Due to its physicochemical characteristics, ibuprofen degradation is difficult in the environment or by microorganisms. There are experimental studies that are currently focused on the problem of drugs as potential environmental contaminants. However, these studies are insufficient to address this ecological issue worldwide. This review focuses on deepening and updating the information concerning ibuprofen as a potential emerging environmental contaminant and the potential for using bacteria for its biodegradation as an alternative technology.

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5

&NA;. "Ibuprofen see Indomethacin/ibuprofen." Reactions Weekly &NA;, no. 304 (June 1990): 7. http://dx.doi.org/10.2165/00128415-199003040-00023.

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6

Abbas Mayar Hezam. "Design of a bacterial system using Escherichia coli to detect the mutagenic effect of some drugs." Al-Qadisiyah Journal of Pure Science 27, no. 1 (February 15, 2023): 21–30. http://dx.doi.org/10.29350/qjps.2022.27.1.1604.

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The current study aimed to use the auxotroph's tryptophan Escherichia coli as a test to detect Ibuprofen's mutagenic potential. the Ames test was used to detect reverse mutations in auxotroph's E. coli treated with Ibuprofen. The results showed a significant increase (P< 0.05) in reverse colonies of auxotroph's E. coli treated with 250 and 500 mg/mL of Ibuprofen compared to the negative control. The polymerase chain reaction and DNA Sequencing were used to detect the reverse mutations in the try gene of the auxotroph's E. coli. The results showed the presence of the try gene in all isolates treated with 250 and 500 mg/mL of Ibuprofen at a percentage of (100%). The try gene was sequenced using BLAST software and compared to the gene sequence of a standard isolate. The genetic variation analysis of the try gene isolates treated with Ibuprofen revealed that point mutations in the DNA of the try gene altered protein translation.

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7

Bedis, Smita, and Priydarshani Kamble. "Ibuprofen Nanoemulsion as a Promising Drug Delivery Strategy." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (June 30, 2022): 965–69. http://dx.doi.org/10.25258/ijddt.12.3.07.

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Phenyl propionic acid derivative drug Ibuprofen was selected for the study’s model medication. It is hypothesized that nanoemulsion might be a useful medication delivery method for enhancing oral absorption. According to the findings, the nanoemulsion formulation greatly enhanced the drug’s anti-inflammatory capabilities when compared to the Ibuprofen solution. Ibuprofen’s solubility and oral bioavailability are enhanced using nanoemulsion technology. To evaluate and pinpoint nanoemulsion area’s are made of glycerol, olive oil, and various sucrose esters, a pseudo ternary phase diagram was created (co-surfactant). Following the discovery of such a nanoemulsion zone, a colloidal system was created to serve as an ibuprofen carrier system. Droplet size, polydispersity index, zeta potential, and morphological measurements were made to determine the characteristics of the chosen nanoemulsion (NE) area.

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8

Mahmood, Syed, Samah Hamed Almurisi, Khater AL-Japairai, Ayah Rebhi Hilles, Walla Alelwani, Azzah M. Bannunah, Farhan Alshammari, and Fawaz Alheibshy. "Ibuprofen-Loaded Chitosan–Lipid Nanoconjugate Hydrogel with Gum Arabic: Green Synthesis, Characterisation, In Vitro Kinetics Mechanistic Release Study and PGE2 Production Test." Gels 7, no. 4 (December 8, 2021): 254. http://dx.doi.org/10.3390/gels7040254.

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Ibuprofen is a well-known non-steroidal anti-inflammatory (NSAID) medicine that is often used to treat inflammation in general. When given orally, it produces gastrointestinal issues which lead to lower patient compliance. Ibuprofen transdermal administration improves both patient compliance and the efficacy of the drug. Nanoconjugation hydrogels were proposed as a controlled transdermal delivery tool for ibuprofen. Six formulations were prepared using different compositions including chitosan, lipids, gum arabic, and polyvinyl alcohol, through ionic interaction, maturation, and freeze–thaw methods. The formulations were characterised by size, drug conjugation efficiency, differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). Further analysis of optimised hydrogels was performed, including X-ray diffraction (XRD), rheology, gel fraction and swelling ability, in vitro drug release, and in vitro macrophage prostaglandin E2 (PGE2) production testing. The effects of ibuprofen’s electrostatic interaction with a lipid or polymer on the physicochemical and dissolution characterisation of ibuprofen hydrogels were evaluated. The results showed that the S3 (with lipid conjugation) hydrogel provided higher conjugation efficiency and prolonged drug release compared with the S6 hydrogel.

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9

&NA;. "Ibuprofen see Ampicillin/aspirin/ibuprofen." Reactions Weekly &NA;, no. 334 (January 1991): 8. http://dx.doi.org/10.2165/00128415-199103340-00046.

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10

Stock, K. P., G. Geisslinger, D. Loew, W. S. Beck, G. L. Bach, and K. Brune. "S-Ibuprofen versus ibuprofen-racemate." Rheumatology International 11, no. 4-5 (November 1991): 199–202. http://dx.doi.org/10.1007/bf00332562.

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11

Hartini, Putri Sri, Nurdiana Dewi, and Lisda Hayatie. "Esktrak ikan haruan (Channa striata) menurunkan jumlah makrofag pada fase inflamasi proses penyembuhan luka (Extract of haruan (Channa striata) decreases macrophages count in inflammation phase of wound healing process )." Journal of Dentomaxillofacial Science 14, no. 1 (February 28, 2015): 6. http://dx.doi.org/10.15562/jdmfs.v14i1.417.

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Haruan is a kind of freshwater fishes commonly found in South Kalimantan. Haruan extract contains nutritional substancessuch as albumin, Zn, Fe, Cu, and unsaturated fatty acid which can help accelerate wound healing. The aim of this studywas to histopathologically assess the effect of 100%, 50%, and 25%haruan extract compared to aquadest and ibuprofenon macrophages count in inflammation phase of wistar rats’ buccal mucosa wound healing. This research was a trueexperimental with post test-only with control design. Samples used were 30 wistar rats divided into 5 groups, 100%, 50%,25% haruan extract treatment groups, ibuprofen treatment group as positive control, and aquadest treatment group asnegative control. Mean macrophages counted on day 3 of 100%, 50%, 25% haruan extract treatment groups aquadest,and ibuprofenl were 2.05, 4.4, 3.9, 3.3, 2.4 respectively. In conclusion, haruan extract had a significant effect in decreasingmacrophages count in inflammation phase of wound healing.

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12

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1380 (December 2011): 24. http://dx.doi.org/10.2165/00128415-201113800-00085.

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13

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1383 (January 2012): 22. http://dx.doi.org/10.2165/00128415-201213830-00076.

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14

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1384 (January 2012): 31. http://dx.doi.org/10.2165/00128415-201213840-00126.

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15

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1385 (January 2012): 23. http://dx.doi.org/10.2165/00128415-201213850-00081.

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16

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1385 (January 2012): 23. http://dx.doi.org/10.2165/00128415-201213850-00082.

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17

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1391 (March 2012): 24–25. http://dx.doi.org/10.2165/00128415-201213910-00088.

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18

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1391 (March 2012): 25. http://dx.doi.org/10.2165/00128415-201213910-00091.

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19

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 706 (June 1998): 8. http://dx.doi.org/10.2165/00128415-199807060-00023.

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20

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 723 (October 1998): 8. http://dx.doi.org/10.2165/00128415-199807230-00023.

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21

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 724 (October 1998): 8. http://dx.doi.org/10.2165/00128415-199807240-00023.

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22

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 765 (August 1999): 7. http://dx.doi.org/10.2165/00128415-199907650-00020.

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23

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1166 (August 2007): 14. http://dx.doi.org/10.2165/00128415-200711660-00044.

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24

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1170 (September 2007): 20. http://dx.doi.org/10.2165/00128415-200711700-00048.

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&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1174 (October 2007): 17. http://dx.doi.org/10.2165/00128415-200711740-00050.

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26

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1183 (January 2008): 17. http://dx.doi.org/10.2165/00128415-200811830-00051.

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27

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1185 (January 2008): 18. http://dx.doi.org/10.2165/00128415-200811850-00054.

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28

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1189 (February 2008): 21. http://dx.doi.org/10.2165/00128415-200811890-00066.

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&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1192 (March 2008): 20. http://dx.doi.org/10.2165/00128415-200811920-00054.

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&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1194-1195 (March 2008): 21. http://dx.doi.org/10.2165/00128415-200811940-00076.

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31

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1119 (September 2006): 14. http://dx.doi.org/10.2165/00128415-200611190-00044.

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32

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1121 (September 2006): 14–15. http://dx.doi.org/10.2165/00128415-200611210-00046.

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33

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1140 (February 2007): 13. http://dx.doi.org/10.2165/00128415-200711400-00043.

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&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1142 (March 2007): 17. http://dx.doi.org/10.2165/00128415-200711420-00045.

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&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1153 (May 2007): 14. http://dx.doi.org/10.2165/00128415-200711530-00045.

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36

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1158 (June 2007): 16. http://dx.doi.org/10.2165/00128415-200711580-00044.

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37

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1160 (July 2007): 20. http://dx.doi.org/10.2165/00128415-200711600-00057.

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38

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1357 (June 2011): 18. http://dx.doi.org/10.2165/00128415-201113570-00058.

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&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 1363 (August 2011): 22. http://dx.doi.org/10.2165/00128415-201113630-00082.

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40

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 604 (June 1996): 7. http://dx.doi.org/10.2165/00128415-199606040-00022.

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41

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 426 (November 1992): 8. http://dx.doi.org/10.2165/00128415-199204260-00029.

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&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 429 (November 1992): 10. http://dx.doi.org/10.2165/00128415-199204290-00049.

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43

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 460 (July 1993): 8. http://dx.doi.org/10.2165/00128415-199304600-00029.

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&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 464 (August 1993): 7. http://dx.doi.org/10.2165/00128415-199304640-00035.

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&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 466 (August 1993): 8. http://dx.doi.org/10.2165/00128415-199304660-00040.

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&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 473 (October 1993): 9. http://dx.doi.org/10.2165/00128415-199304730-00042.

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47

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 619 (September 1996): 8. http://dx.doi.org/10.2165/00128415-199606190-00024.

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48

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 646 (April 1997): 7. http://dx.doi.org/10.2165/00128415-199706460-00017.

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49

&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 663 (August 1997): 8. http://dx.doi.org/10.2165/00128415-199706630-00016.

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&NA;. "Ibuprofen." Reactions Weekly &NA;, no. 670 (September 1997): 8. http://dx.doi.org/10.2165/00128415-199706700-00025.

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