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Journal articles on the topic 'ICampus'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Bromuri, Stefano, Visara Urovi, and Kostas Stathis. "iCampus." International Journal of Ambient Computing and Intelligence 2, no. 1 (2010): 59–65. http://dx.doi.org/10.4018/jaci.2010010105.

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iCampus is a prototype multi-agent system whose goal is to provide the ambient intelligence required to connect people in a university campus and make that campus inclusive and accessible. Software agents called guides run on mobile phones to help students with information about people, places, and events, thus providing people real-time, location-based advice that makes them more aware of what is going on in the campus. The work outlines how to specify iCampus in the Ambient Event Calculus and implement it using the agent environment GOLEM to deploy guide agents over a campus network. The wor

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Wu, Ding Wei, Qiang Wu, Xi Cheng Fu, Zhi Zhong Ye, and Jia Lun Lin. "A New Hybrid Storage System Base on Openstack." Applied Mechanics and Materials 556-562 (May 2014): 5371–76. http://dx.doi.org/10.4028/www.scientific.net/amm.556-562.5371.

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In recent years, hybrid storage has gradually become a hotspot in the research of data storage owing to its high-performance and low cost. An OpenStack-based hybrid storage system is presented in this paper. According to the characteristics, the data is divided into small data, big data and temporary data in this hybrid storage system; meanwhile a storage strategy, combining database storage system, the virtual file system and servers file system, is designed. In the application of iCampus project, this proposed hybrid storage system shows better performance and higher efficiency than the trad

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Lebrun, Marcel. "Enseigner et apprendre en ligne. Claroline et le site iCampus de l’UCL : fondements, outils, dispositifs." Les dossiers des sciences de l’éducation 12, no. 1 (2004): 79–93. http://dx.doi.org/10.3406/dsedu.2004.1049.

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Beier, Meghan, Kevin Alschuler, Dagmar Amtmann, Abbey Hughes, Renee Madathil, and Dawn Ehde. "iCAMS." International Journal of MS Care 22, no. 2 (2020): 67–74. http://dx.doi.org/10.7224/1537-2073.2018-108.

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Abstract Background: This study aimed to develop a Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) tablet application, “iCAMS,” and examine equivalency between the original paper-based and the tablet-based assessments. Methods: This study enrolled 100 participants with physician-confirmed multiple sclerosis (MS). Interrater reliability, parallel forms reliability, and concurrent validity were evaluated by incorporating two test administrators in each session: one scoring participant responses with the original paper assessments and the other with iCAMS. Although the pa

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Eljaiek-Urzola, Mónica, Nora Romero-Sierra, Laura Segrera-Cabarcas, David Valdelamar-Martínez, and Édgar Quiñones-Bolaños. "Oil and Grease as a Water Quality Index Parameter for the Conservation of Marine Biota." Water 11, no. 4 (2019): 856. http://dx.doi.org/10.3390/w11040856.

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Water quality indexes are a tool used to evaluate the physicochemical characteristics of a water body according to its use. The present study proposes the inclusion of oil and grease (OG) as a new water quality index (ICAMPFF-GA) parameter for the preservation of marine biota in tropical areas, since it is a typical pollutant found and measured in water bodies, causing damage to the aquatic environment. The normalized curve for OG was defined based on the percentage of surviving microorganism under a lethal concentration exposure of OG. The ICAMPFF-GA suitability was evaluated by its applicati

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Thabrew, Hiran, Ernest Gandeza, Giselle Bahr, et al. "The management of young people who self-harm by New Zealand Infant, Child and Adolescent Mental Health Services: cutting-edge or cutting corners?" Australasian Psychiatry 26, no. 2 (2018): 152–59. http://dx.doi.org/10.1177/1039856217748248.

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Objectives: Self-harm is common in New Zealand (NZ) young people and can have short-term and long-term consequences, including suicide. This study was undertaken to examine the extent to which evidence-based approaches for addressing self-harm are offered by Infant, Child and Adolescent Mental Health Services (ICAMHS). Methods: A national survey of ICAMHS practitioners working with young people who self-harm was undertaken between May and July 2016. Results: Responses from 23 out of 30 ICAMHS confirmed self-harm was a familiar presentation and most commonly associated with diagnoses of depress

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Thomas, Andrew, Hanifa Shah, Philip Moore, et al. "Challenges and Opportunities for the Future of iCampuses." Computer Science 14, no. 1 (2013): 5. http://dx.doi.org/10.7494/csci.2013.14.1.5.

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Swandulla, D. "Cationic membrane conductances induced by intracellularly elevated cAMP and Ca2+: measurements with ion-selective microelectrodes." Canadian Journal of Physiology and Pharmacology 65, no. 5 (1987): 898–903. http://dx.doi.org/10.1139/y87-145.

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Adenosine 3′,5′-cyclic monophosphate (cAMP) and CaCl2 were injected by a fast and quantitative pressure injection technique into voltage-clamped, identified Helix neurons. Intracellular elevation of cAMP as well as of Ca2+ activated an inward current (IcAMP and IN). To identify the ionic fluxes during IcAMP and IN changes in [Na+]i, [K+]o, [H+]i, and [Cl−]i were measured with ion-selective microelectrodes (ISMs). Near resting potential, Na+ was the main carrier of IcAMP. K+, and less effectively Ca2+, could substitute for Na+ in carrying IcAMp. H+ and Cl− were excluded as current carriers for

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Wang, Jian-Hua, Constance Kwas, and Li Wu. "Intercellular Adhesion Molecule 1 (ICAM-1), but Not ICAM-2 and -3, Is Important for Dendritic Cell-Mediated Human Immunodeficiency Virus Type 1 Transmission." Journal of Virology 83, no. 9 (2009): 4195–204. http://dx.doi.org/10.1128/jvi.00006-09.

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ABSTRACT Dendritic cells (DCs) play a critical role in cell-to-cell-mediated transmission of human immunodeficiency virus type 1 (HIV-1). Interactions between intercellular adhesion molecules (ICAMs) and their ligands facilitate DC-T-cell contact. The interaction between ICAM-1 on DCs and leukocyte function-associated molecule 1 (LFA-1) on CD4+ T cells has been proposed to be important for DC-mediated HIV-1 transmission. Given that DCs and T cells express multiple ICAMs and binding ligands, the relative importance of ICAMs in DC-mediated HIV-1 transmission remains to be defined. Here, we exami

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Resnick, Barbara, Ruth Carrico, Stefan Gravenstein, et al. "Dissemination and implementation of the ICAMP." Translational Behavioral Medicine 8, no. 6 (2018): 867–75. http://dx.doi.org/10.1093/tbm/iby069.

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Xiao, Xiang, Dolores D. Mruk, and C. Yan Cheng. "Intercellular adhesion molecules (ICAMs) and spermatogenesis." Human Reproduction Update 19, no. 2 (2013): 167–86. http://dx.doi.org/10.1093/humupd/dms049.

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12

Froes, F. H. (Sam). "The First International Conference On Advanced Materials Processing (Icamp)." Materials Technology 16, no. 1 (2001): 57–61. http://dx.doi.org/10.1080/10667857.2001.11752909.

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13

Yang, Heping. "Structure, Expression, and Function of ICAM-5." Comparative and Functional Genomics 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/368938.

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Cell adhesion is of utmost importance in normal development and cellular functions. ICAM-5 (intercellular adhesion molecule-5, telencephalin, TLN) is a member of the ICAM family of adhesion proteins. As a novel cell adhesion molecule, ICAM-5 shares many structural similarities with the other members of IgSF, especially the ICAM subgroup; however, ICAM-5 has several unique properties compared to the other ICAMs. With its nine extracellular Ig domains, ICAM-5 is the largest member of ICAM subgroup identified so far. Therefore, it is much more complex than the other ICAMs. The expression of ICAM-

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AFONIN, Andrej. "Distributed Social Bookmarking Web Service Architecture. SOAP vs. iCamp FeedBack." Informatics in Education 10, no. 2 (2011): 149–62. http://dx.doi.org/10.15388/infedu.2011.10.

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Choi, Jin-Young, Seung-Yeon Kim, Sung-Chul Hong, et al. "Evaluation of Temperature and Precipitation on Integrated Climate and Air Quality Modeling System (ICAMS) for Air Quality Prediction." Journal of Korean Society for Atmospheric Environment 28, no. 6 (2012): 615–31. http://dx.doi.org/10.5572/kosae.2012.28.6.615.

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Nakanishi, Y., K. Takahashi, T. Tsuji, and K. Hakozaki. "Mobile communications - icams: a mobile communication tool using location and schedule information." IEEE Pervasive Computing 3, no. 1 (2004): 82–88. http://dx.doi.org/10.1109/mprv.2004.1269136.

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Alasehirli, Belgin, Elif Oğuz, Ebru Oksuzler, et al. "Investigation of intercellular adhesion molecules (ICAMs) gene expressions in patients with Barrett's esophagus." Tumor Biology 35, no. 5 (2014): 4907–12. http://dx.doi.org/10.1007/s13277-014-1644-3.

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Akhmedov, Vadim A., and Olga V. Gaus. "Inflammatory diseases of the pancreas: what new do we know about the mechanisms of their development in the 21st century?" Terapevticheskii arkhiv 93, no. 1 (2021): 66–70. http://dx.doi.org/10.26442/00403660.2021.01.200595.

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Inflammatory diseases of the pancreas can range from acute to acute recurrent and chronic pancreatitis. With the improvement of laboratory diagnostics in the 21st century, the mechanisms of the pro-inflammatory and anti-inflammatory role of tight junctions, in particular the transmembrane proteins occludin, claudine and JAMs, cytoplasmic Zo-proteins, and adherens junctions, in particular -catenin, -catenin, E-cadherin, selectins and ICAMs in the pathogenesis of acute and chronic pancreatitis have become more clear. The study of genetic factors in the development of acute and chronic pancreatit

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Zaretsky, Irina, Ofir Atrakchi, Roei D. Mazor, et al. "ICAMs support B cell interactions with T follicular helper cells and promote clonal selection." Journal of Experimental Medicine 214, no. 11 (2017): 3435–48. http://dx.doi.org/10.1084/jem.20171129.

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The germinal center (GC) reaction begins with a diverse and expanded group of B cell clones bearing a wide range of antibody affinities. During GC colonization, B cells engage in long-lasting interactions with T follicular helper (Tfh) cells, a process that depends on antigen uptake and antigen presentation to the Tfh cells. How long-lasting T–B interactions and B cell clonal expansion are regulated by antigen presentation remains unclear. Here, we use in vivo B cell competition models and intravital imaging to examine the adhesive mechanisms governing B cell selection for GC colonization. We

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Jiménez, David, Pedro Roda-Navarro, Timothy A. Springer, and José M. Casasnovas. "Contribution ofN-Linked Glycans to the Conformation and Function of Intercellular Adhesion Molecules (ICAMs)." Journal of Biological Chemistry 280, no. 7 (2004): 5854–61. http://dx.doi.org/10.1074/jbc.m412104200.

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Walter, Nicole A. R., Justin Stebbing, and Walter Messier. "The potential significance of adaptive evolution and dimerization in chimpanzee intercellular cell adhesion molecules (ICAMs)." Journal of Theoretical Biology 232, no. 3 (2005): 339–46. http://dx.doi.org/10.1016/j.jtbi.2004.08.024.

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22

del Pozo, M. A., C. Cabañas, M. C. Montoya, A. Ager, P. Sánchez-Mateos, and F. Sánchez-Madrid. "ICAMs redistributed by chemokines to cellular uropods as a mechanism for recruitment of T lymphocytes." Immunology Letters 56 (May 1997): 105. http://dx.doi.org/10.1016/s0165-2478(97)85415-6.

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del Pozo, M. "ICAMs redistributed by chemokines to cellular uropods as a mechanism for recruitment of T lymphocytes." Immunology Letters 56, no. 1-3 (1997): 105. http://dx.doi.org/10.1016/s0165-2478(97)87253-7.

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Pozo, Miguel Angel del, Carlos Cabañas, María C. Montoya, Ann Ager, Paloma Sánchez-Mateos, and Francisco Sánchez-Madrid. "ICAMs Redistributed by Chemokines to Cellular Uropods as a Mechanism for Recruitment of T Lymphocytes." Journal of Cell Biology 137, no. 2 (1997): 493–508. http://dx.doi.org/10.1083/jcb.137.2.493.

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The recruitment of leukocytes from the bloodstream is a key step in the inflammatory reaction, and chemokines are among the main regulators of this process. During lymphocyte–endothelial interaction, chemokines induce the polarization of T lymphocytes, with the formation of a cytoplasmic projection (uropod) and redistribution of several adhesion molecules (ICAM-1,-3, CD43, CD44) to this structure. Although it has been reported that these cytokines regulate the adhesive state of integrins in leukocytes, their precise mechanisms of chemoattraction remain to be elucidated. We have herein studied

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YI, J., R. FERREIRA, and L. L. TAVLARIDES. "Application of Inorganic Chemically Active Membranes (ICAMs) for Copper Ion Separation from Acidic Sulfate Solutions." Hazardous Waste and Hazardous Materials 9, no. 2 (1992): 173–89. http://dx.doi.org/10.1089/hwm.1992.9.173.

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26

Halbert, Martin. "The Problematic Future of Research Data Management: Challenges, Opportunities and Emerging Patterns Identified by the DataRes Project." International Journal of Digital Curation 8, no. 2 (2013): 111–22. http://dx.doi.org/10.2218/ijdc.v8i2.276.

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This paper describes findings and projections from a project that has examined emerging policies and practices in the United States regarding the long-term institutional management of research data. The DataRes project at the University of North Texas (UNT) studied institutional transitions taking place during 2011-2012 in response to new mandates from U.S. governmental funding agencies requiring research data management plans to be submitted with grant proposals. Additional synergistic findings from another UNT project, termed iCAMP, will also be reported briefly.This paper will build on thes

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de Fougerolles, A. R., and T. A. Springer. "Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes." Journal of Experimental Medicine 175, no. 1 (1992): 185–90. http://dx.doi.org/10.1084/jem.175.1.185.

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Recent studies suggest that some T and B lymphocyte cell lines bind to the integrin lymphocyte function-associated molecule 1 (LFA-1) chiefly through a pathway independent of its two known counter-receptors, intercellular adhesion molecules (ICAMs)-1 and -2. A monoclonal antibody (mAb) was raised that, in combination with blocking mAb to ICAM-1 and ICAM-2, can completely inhibit binding of these cell lines to purified LFA-1. This third ligand, designated ICAM-3 based on its functional relatedness to ICAM-1 and -2, is a highly glycosylated protein of 124,000 Mr. It is well expressed on all leuk

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Feigelson, Sara W., Adam Solomon, Adi Biram, et al. "ICAMs Are Not Obligatory for Functional Immune Synapses between Naive CD4 T Cells and Lymph Node DCs." Cell Reports 22, no. 4 (2018): 849–59. http://dx.doi.org/10.1016/j.celrep.2017.12.103.

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Jaksic, Branimir, Ozren Jaksic, Mirjana M. Kardum-Paro, and Ika Kardum-Skelin. "Differences between Peripheral Blood, Lymph Nodes and Bone Marrow in Expression of Integrins, ICAMs, CD38 and CD31 Correlate with Clinical Characteristics in B-CLL." Blood 106, no. 11 (2005): 4981. http://dx.doi.org/10.1182/blood.v106.11.4981.4981.

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Abstract B-CLL patients have variable tumor mass distribution within major cell compartments, and as a consequence different clinical presentation. Adhesion molecules (AM) expression phenotype of integrins (CD11a, CD11b, CD11c, CD18, CD29, CD49c, CD49d and CD61), ICAMs (CD54, CD102 and CD50), CD38 and CD31 was determined in samples taken from peripheral blood (PB), bone marrow (BM) and lymph nodes (LN) by two/three color flow cytometry in 33 B-CLL patients. Differences for particular AM expression between compartments were quantified to express respective intensity and direction (gradients). W

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Fan, Zhichao, William Bill Kiosses, Hao Sun та ін. "High-Affinity Bent β2-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis". Cell Reports 26, № 1 (2019): 119–30. http://dx.doi.org/10.1016/j.celrep.2018.12.038.

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Bajtay, Zsuzsa. "Biologia Futura: stories about the functions of β2-integrins in human phagocytes". Biologia Futura 72, № 1 (2021): 7–13. http://dx.doi.org/10.1007/s42977-020-00063-z.

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AbstractIntegrins are essential membrane proteins that provide a tightly regulated link between the extracellular matrix and the intracellular cytoskeletal network. These cell surface proteins are composed of a non-covalently bound α chain and β chain. The leukocyte-specific complement receptor 3 (CR3, αMβ2, CD11b/CD18) and complement receptor 4 (CR4, αXβ2, CD11c/CD18) belong to the family of β2-integrins. These receptors bind multiple ligands like iC3b, ICAMs, fibrinogen or LPS, thus allowing them to partake in phagocytosis, cellular adhesion, extracellular matrix rearrangement and migration.

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Tian, Li, Jani Lappalainen, Matti Autero, Satu Hänninen, Heikki Rauvala, and Carl G. Gahmberg. "Shedded neuronal ICAM-5 suppresses T-cell activation." Blood 111, no. 7 (2008): 3615–25. http://dx.doi.org/10.1182/blood-2007-09-111179.

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Abstract Intercellular adhesion molecules (ICAMs) bind to leukocyte β2 integrins, which, among other functions, provide costimulatory signals for T-cell activation. ICAM-5 (telencephalin) is expressed in the somadendritic region of neurons of the mammalian brain. The receptor for ICAM-5 is the integrin LFA-1, a major leukocyte integ-rin expressed in lymphocytes and microglia. In conditions of brain ischemia, epilepsy, and encephalitis, the soluble form of ICAM-5 (sICAM-5) has been detected in physiologic fluids. Here, we report that sICAM-5 attenuates the T-cell receptor-mediated activation of

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Satoh, J., S. U. Kim, L. F. Kastrukoff, and F. Takei. "Expression and induction of intercellular adhesion molecules (ICAMs) and major histocompatibility complex (MHC) antigens on cultured murine oligodendrocytes and astrocytes." Journal of Neuroscience Research 29, no. 1 (1991): 1–12. http://dx.doi.org/10.1002/jnr.490290102.

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Richter, M. H. C., H. Bittner, J. F. Gummert, and F. W. Mohr. "THE EFFECT OF CSA, FK506 AND MMF ON THE EXPRESSION OF INDUCIBLE CELL ADHESION MOLECULES (ICAMS), TRANSPLANT VASCULOPATHY AND LEUKOCYTE INFILTRATION." Transplantation 78 (July 2004): 548. http://dx.doi.org/10.1097/00007890-200407271-01478.

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&NA;. "THE EFFECT OF CSA, FK506 AND MMF ON THE EXPRESSION OF INDUCIBLE CELL ADHESION MOLECULES (iCAMs), TRANSPLANT VASCULOPATHY AND LEUKOCYTE INFILTRATION." Transplantation 82, Suppl 2 (2006): 898. http://dx.doi.org/10.1097/00007890-200607152-02519.

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Richter, M. H. C., A. Rahmel, H. Bittner, J. Gummert, and F. W. Mohr. "The effect of CSA, FK506 and MMF on the expression of inducible cell adhesion molecules (iCAMs), transplant vasculopathy and leukocyte infiltration." Journal of Heart and Lung Transplantation 23, no. 2 (2004): S68. http://dx.doi.org/10.1016/j.healun.2003.11.077.

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Katagiri, Koko, Masakazu Hattori, Nagahiro Minato, and Tatsuo Kinashi. "Rap1 Functions as a Key Regulator of T-Cell and Antigen-Presenting Cell Interactions and Modulates T-Cell Responses." Molecular and Cellular Biology 22, no. 4 (2002): 1001–15. http://dx.doi.org/10.1128/mcb.22.4.1001-1015.2002.

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ABSTRACT Activation of T cells by antigen requires adhesive interactions with antigen-presenting cells (APC) in which leukocyte function-associated antigen 1 (LFA-1) and intercellular adhesion molecules (ICAMs) are important. However, it is not well understood what signaling molecules regulate this process and how the modulation of adhesive events influences T-cell activation. Here we show that Rap1 is activated in T cells in an antigen-dependent manner and accumulated at the contact site of T-cell and antigen-loaded APC. Inhibition of Rap1 activation by a dominant-negative Rap1 or SPA-1, a Ra

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Elangbam, C. S., C. W. Qualls, and R. R. Dahlgren. "Cell Adhesion Molecules—Update." Veterinary Pathology 34, no. 1 (1997): 61–73. http://dx.doi.org/10.1177/030098589703400113.

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Cell adhesion molecules are glycoproteins expressed on the cell surface and play an important role in inflammatory as well as neoplastic diseases. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. The integrin family has eight subfamilies, designated as β1, through β8. The most widely studied subfamilies are β1 (CD29, very late activation [VLA] members), β2 (leukocyte integrins such as CDlla/CD18, CDllb/CD18, CDllc/CD18, and αdβ2), β3 (CD61, eytoadhesions), and β7 (α4β7 and αEβ7). The immunoglobulin superfamily includes leukocyte functio

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Li, R., J. Xie, C. Kantor, et al. "A peptide derived from the intercellular adhesion molecule-2 regulates the avidity of the leukocyte integrins CD11b/CD18 and CD11c/CD18." Journal of Cell Biology 129, no. 4 (1995): 1143–53. http://dx.doi.org/10.1083/jcb.129.4.1143.

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beta 2 integrin (CD11a,b,c/CD18)-mediated cell adhesion is required for many leukocyte functions. Under normal circumstances, the integrins are nonadhesive, and become adhesive for their cell surface ligands, the intercellular adhesion molecules (ICAMs), or soluble ligands such as fibrinogen and iC3b, when leukocytes are activated. Recently, we defined a peptide derived from ICAM-2, which specifically binds to purified CD11a/CD18. Furthermore, this peptide strongly induces T cell aggregation mainly mediated by CD11a/CD18-ICAM-1 interaction, and natural killer cell cytotoxicity. In the present

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Potor, László, Katalin Éva Sikura, Hajnalka Hegedűs, et al. "The Fungal Iron Chelator Desferricoprogen Inhibits Atherosclerotic Plaque Formation." International Journal of Molecular Sciences 21, no. 13 (2020): 4746. http://dx.doi.org/10.3390/ijms21134746.

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Hemoglobin, heme and iron are implicated in the progression of atherosclerosis. Therefore, we investigated whether the hydrophobic fungal iron chelator siderophore, desferricoprogen (DFC) inhibits atherosclerosis. DFC reduced atherosclerotic plaque formation in ApoE−/− mice on an atherogenic diet. It lowered the plasma level of oxidized LDL (oxLDL) and inhibited lipid peroxidation in aortic roots. The elevated collagen/elastin content and enhanced expression of adhesion molecule VCAM-1 were decreased. DFC diminished oxidation of Low-density Lipoprotein (LDL) and plaque lipids catalyzed by heme

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Fagerholm, Susanna C., Minna Varis, Michael Stefanidakis, Tiina J. Hilden та Carl G. Gahmberg. "α-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation". Blood 108, № 10 (2006): 3379–86. http://dx.doi.org/10.1182/blood-2006-03-013557.

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Abstract The promiscuous CD11b/CD18 (Mac-1) integrin has important roles in regulating many immunologic functions such as leukocyte adhesion and emigration from the bloodstream via interactions with the endothelial ligands ICAM-1 and ICAM-2, iC3b-mediated phagocytosis, and apoptosis. However, the mechanisms for Mac-1 inside-out activation have remained poorly understood. Phosphorylation of integrin cytoplasmic domains is emerging as an important mechanism of regulating integrin functions. Here, we have studied phosphorylation of human CD11b, which takes place on the cytoplasmic Ser1126 in neut

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Tracey, Karen L., Stephan D. Howden, and D. Randolph Watts. "IES Calibration and Mapping Procedures." Journal of Atmospheric and Oceanic Technology 14, no. 6 (1997): 1483–93. http://dx.doi.org/10.1175/1520-0426(1997)014<1483:icamp>2.0.co;2.

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Zamai, Loris, Genny Del Zotto, Flavia Buccella, et al. "Understanding the Synergy of NKp46 and Co-Activating Signals in Various NK Cell Subpopulations: Paving the Way for More Successful NK-Cell-Based Immunotherapy." Cells 9, no. 3 (2020): 753. http://dx.doi.org/10.3390/cells9030753.

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The NK cell population is characterized by distinct NK cell subsets that respond differently to the various activating stimuli. For this reason, the determination of the optimal cytotoxic activation of the different NK cell subsets can be a crucial aspect to be exploited to counter cancer cells in oncologic patients. To evaluate how the triggering of different combination of activating receptors can affect the cytotoxic responses of different NK cell subsets, we developed a microbead-based degranulation assay. By using this new assay, we were able to detect CD107a+ degranulating NK cells even

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Snyder, Greg A., Jennifer Ford, Parizad Torabi-Parizi, et al. "Characterization of DC-SIGN/R Interaction with Human Immunodeficiency Virus Type 1 gp120 and ICAM Molecules Favors the Receptor's Role as an Antigen-Capturing Rather than an Adhesion Receptor." Journal of Virology 79, no. 8 (2005): 4589–98. http://dx.doi.org/10.1128/jvi.79.8.4589-4598.2005.

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ABSTRACT The dendritic cell (DC)-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin binding receptor (DC-SIGN) was shown to bind human immunodeficiency virus type 1 (HIV-1) viral envelope protein gp120 and proposed to function as a Trojan horse to enhance trans-virus infection to host T cells. To better understand the mechanism by which DC-SIGN and DC-SIGNR selectively bind HIV-1 gp120, we constructed a series of deletion mutations in the repeat regions of both receptors. Different truncated receptors exist in different oligomeric forms. The carbohydrate binding domain wi

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Gholizadeh, Mohammad, Said Abdul Ghafour Saeedy, Poorya Basafay Roodi та Ahmad Saedisomeolia. "The association between zinc and endothelial adhesion molecules ICAMs and VCAM-1 and nuclear receptors PPAR-ɑ and PPAR-γ: A systematic review on cell culture, animal and human studies". Microvascular Research 138 (листопад 2021): 104217. http://dx.doi.org/10.1016/j.mvr.2021.104217.

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Baxter, D. A., and J. H. Byrne. "Serotonergic modulation of two potassium currents in the pleural sensory neurons of Aplysia." Journal of Neurophysiology 62, no. 3 (1989): 665–79. http://dx.doi.org/10.1152/jn.1989.62.3.665.

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1. The properties of membrane currents that were modulated by serotonin (5-HT) were investigated with two-electrode voltage-clamp techniques in sensory neuron somata isolated from the pleural ganglion of Aplysia californica. The modulatory effects of 5-HT were revealed by computer subtraction of current responses elicited in the presence of 5-HT from current responses elicited prior to the application of 5-HT. The complexities of the resulting 5-HT difference currents (I5-HT) suggested that 5-HT modulated more than one component of membrane current. 2. The 5-HT difference currents appeared to

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Baxter, D. A., and J. H. Byrne. "Differential effects of cAMP and serotonin on membrane current, action-potential duration, and excitability in somata of pleural sensory neurons of Aplysia." Journal of Neurophysiology 64, no. 3 (1990): 978–90. http://dx.doi.org/10.1152/jn.1990.64.3.978.

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1. In somata of sensory neurons in the pleural ganglia of Aplysia californica, serotonin (5-HT) modulates at least three K+ currents: the S K+ current (IK,S), a slow component of the Ca2(+)-activated K+ current (IK,Ca), and the delayed or voltage-dependent K+ current (IK,V). The modulation of IK,S and the slow component of IK,Ca by 5-HT has been shown previously to be mediated via adenosine 3',5'-cyclic monophosphate (cAMP). To determine whether the modulation of IK,V by 5-HT also is mediated via cAMP, we used two-electrode voltage-clamp techniques to compare the modulation of membrane current

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May, Andreas, Franz-Josef Neumann, and Klaus Preissner. "The Relevance of Blood Cell-Vessel Wall Adhesive Interactions for Vascular Thrombotic Disease." Thrombosis and Haemostasis 82, no. 08 (1999): 962–70. http://dx.doi.org/10.1055/s-0037-1615939.

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IntroductionFollowing an inflammatory or infectious stimulus, the body’s defense mechanism initiates recruitment of circulating leukocytes toward the inflammatory stimulus. The emigration of leukocytes into extravascular tissues occurs in a highly coordinated fashion in multiple steps, including rolling and tethering of blood cells along the vascular endothelium and their firm attachment and subsequent transmigration and invasion toward the inflammatory site.1 During these sequential steps, transcellular recognition of different adhesion receptor/counterligand pairs, such as selectins/sialyl L

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Suck, Garnet, Suet-Mien Tan, Sixian Chu, Madelaine Niam, Tsyr Jong Lim, and Mickey Boon Chai Koh. "Comparative Analysis of LFA-1 Activation State and Functional Involvement in Enhanced Cytotoxicity of NK Cell Lines KHYG-1 and NK-92." Blood 112, no. 11 (2008): 4909. http://dx.doi.org/10.1182/blood.v112.11.4909.4909.

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Abstract Background: KHYG-1 and NK-92 are highly cytotoxic IL-2 dependent NK cell lines. NK cytotoxicity is regulated through an array of receptors with activating and inhibitory functions for spontaneous elimination of pathogen infected or tumor cells. Important roles have been described for the leukocyte function-associated antigen (LFA)- 1 adhesion receptor (αLβ2) in NK cytotoxicity. In T cells, the integrin LFA-1 occurs in a non-functional, bent form and requires activation, through divalent cations e.g., for ligand binding. In marked contrast, IL-2 stimulated NK cells could directly engag

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"ICAMP 2011 Announcement." Psychological Studies 55, no. 4 (2010): 397. http://dx.doi.org/10.1007/s12646-010-0052-z.

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