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Journal articles on the topic 'Icarians'

Author: Grafiati

Published: 22 February 2023

Last updated: 28 July 2024

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1

Wiegenstein, Steve. "The Icarians and Their Neighbors." International Journal of Historical Archaeology 10, no. 3 (2006): 283–89. http://dx.doi.org/10.1007/s10761-006-0011-5.

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PILBEAM, PAMELA. "DREAM WORLDS? RELIGION AND THE EARLY SOCIALISTS IN FRANCE." Historical Journal 43, no. 2 (2000): 499–515. http://dx.doi.org/10.1017/s0018246x99008924.

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This article gives chronology, nuance, and context to an analysis of how early socialist attitudes to religion changed. It asks why socialists argued with increasing fervour between the early 1830s and 1848 that social reform had to be rooted in spiritual as well as moral values. Two of the largest groups, the Icarians and the Fourierists, moved from a rational deism to Christianity. Both were driven by the need to defend themselves from accusations of immorality levelled against Fourier and the Saint-Simonians because of their rejection of monogamous marriage. The Fourierists, strongly influe

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Indratmoko, Septiana, Laela Hayu Nurani, Iis Wahyuningsih, and Rochany Septiyaninsih. "Icariin Research Trends: Bibliometric Analysis." Jurnal Penelitian Pendidikan IPA 9, no. 11 (2023): 955–65. http://dx.doi.org/10.29303/jppipa.v9i11.4717.

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Icariin is a compound with various pharmacological effects, such as anti-osteoporosis, cardiovascular protection, anti-inflammatory, antitumor, immunoprotection, and sexual dysfunction improver. Over the past decades, several publications and literatures have studied the compound and its potential effects. This is a bibliometric analysis of academic studies related to icariin compounds, and their productivity. Therefore, this research aims to comprehensively analyse the findings of several articles related to icariin globally. The articles used were obtained from the Scopus database using the

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Luo, Wei, Junhua Deng, Jinqin Xie, Daizhun Liang, Jie Lu, and Yi Lu. "The Protective Effect of Icariin on Myocardial Injury in Viral Myocarditis Based on the Cyclic Adenosine Monophosphate-Protein Kinase a Signaling Pathway." Nanoscience and Nanotechnology Letters 12, no. 12 (2020): 1378–85. http://dx.doi.org/10.1166/nnl.2020.3254.

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Viral myocarditis (VM) is an inflammatory lesion of the myocardium caused by a viral infection. Icariin has anti-viral effects, but its therapeutic effect and mechanism of VM action are still not clear. This study evaluated icariin’s intervention effect on the myocardial cAMP-PKA signaling pathway and explored the possible mechanism of icariin’s effect. The results showed that a high dose of icariin could improve VM rats’ quality of life. Icariin-treated rats had lower mortality, insignificant weight loss, and decreased CK-MB and LDH. Hematoxylin-Eosin (HE) staining to observe the pathological

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Oprita, Elena Iulia, Andreea Iosageanu, and Oana Craciunescu. "Progress in Composite Hydrogels and Scaffolds Enriched with Icariin for Osteochondral Defect Healing." Gels 8, no. 10 (2022): 648. http://dx.doi.org/10.3390/gels8100648.

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Osteochondral structure reconstruction by tissue engineering, a challenge in regenerative medicine, requires a scaffold that ensures both articular cartilage and subchondral bone remodeling. Functional hydrogels and scaffolds present a strategy for the controlled delivery of signaling molecules (growth factors and therapeutic drugs) and are considered a promising therapeutic approach. Icariin is a pharmacologically-active small molecule of prenylated flavonol glycoside and the main bioactive flavonoid isolated from Epimedium spp. The in vitro and in vivo testing of icariin showed chondrogenic

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Xiong, Jun, Hui Zou та Yi Yu. "Icariin induces autophagy and apoptosis of chondrocytes by inhibiting NF-κB signaling pathway". Tropical Journal of Pharmaceutical Research 19, № 9 (2020): 1851–56. http://dx.doi.org/10.4314/tjpr.v19i9.8.

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Purpose: To investigate the effect of icariin on autophagy and apoptosis of chondrocytes, and the associated mechanisms.Methods: The chondrocytes were randomly divided into control (PBS intervention), TNF-α intervention, icarin +TNF-α, and NF-κB inhibition +TNF-α, with 8 strains in each group. The levels of IL-1, IL-6 and IL-12 were assayed by ELISA. The mRNA and protein expressions of ATG5, ATG7, Bax and Bcl-2 cells were determined by polymerase chain reaction (PCR) and Western blotting, while protein expressions of p-p65 and IκBα were assayed using Western blotting.Results: In the cartilage

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Long, Longhai, Xiaoqiang Wang, Yang Lei, et al. "Icariin: A Potential Alternative Against Osteoporosis." Natural Product Communications 17, no. 11 (2022): 1934578X2211348. http://dx.doi.org/10.1177/1934578x221134881.

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Osteoporosis is a metabolic skeletal disorder characterized by increased fragility and fracture risk as s result of reduced bone mineral density and microstructural destruction and caused a heavy burden on families and society. Current medicines, on the other hand, have some limitations, with side effects and doubts regarding long-term efficacy being highlighted. Studies seeking for natural constituents as potential treatment options therefore come into focus. Icariin is a phytochemical derived from a traditional Chinese medicine, Herba epimedium, that has been used to treat orthopedic disorde

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Kim, Seo-Jin, Myoung-Su Park, Tian Ding, Jun Wang, and Deog-Hwan Oh. "Biological Activities of Isolated Icariin from Epimedium koreanum Nakai." Journal of the Korean Society of Food Science and Nutrition 40, no. 10 (2011): 1397–403. http://dx.doi.org/10.3746/jkfn.2011.40.10.1397.

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9

Xiong, Wen, Haoyue Ma, Zhu Zhang, et al. "The protective effect of icariin and phosphorylated icariin against LPS-induced intestinal goblet cell dysfunction." Innate Immunity 26, no. 2 (2019): 97–106. http://dx.doi.org/10.1177/1753425919867746.

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In this study, we used LS174T cells as a model to investigate the protective effects of icariin and phosphorylated icariin on LPS-induced goblet cell dysfunction. Our results indicated that icariin and phosphorylated icariin increased the cell viability and decreased lactate dehydrogenase activity in LPS-treated LS174T cells. Icariin and phosphorylated icariin attenuated LPS-induced changes in mucin 2 synthesis and secretion. Besides, Icariin and phosphorylated icariin reduced the levels of ROS, MDA, and H2O2 and increased the activity of SOD, GPx, CAT, and T-AOC in LPS-treated LS174T cells. M

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Di Paolo, Maria Grazia. "D'ANNUNZIO'S ICARIAN MYTHOPOESIS." Forum Italicum: A Journal of Italian Studies 44, no. 2 (2010): 287–300. http://dx.doi.org/10.1177/001458581004400202.

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11

Crowley, John W. "An Icarian Fall." Sewanee Review 121, no. 1 (2013): iii—vii. http://dx.doi.org/10.1353/sew.2013.0014.

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Wang, Jiahao, Yuying Sun, and Xiangtong Tian. "The Inhibitory Effect of Icariin Nanoparticles on Angiogenesis in Pulmonary Fibrosis." Journal of Nanoscience and Nanotechnology 21, no. 11 (2021): 5429–35. http://dx.doi.org/10.1166/jnn.2021.19316.

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This study investigated icariin (ICA) nanoparticles on angiogenesis in rats with pulmonary fibrosis and its mechanism. First, icariin solid nanoliposomes (ICA-SLN) were prepared. The in vitrorelease of icariin nanoparticles was determined using a UV-Vis spectrophotometer, after which the plasma concentration of icariin nanoparticles in rats was determined. The bioavailability of icariin nanoparticles was investigated, and the effect of icariin on angiogenesis of pulmonary fibrosis rats was re-observed. The results showed that the bioavailability of icariin in vivo was enhanced after nanomodifi

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13

Indratmoko, Septiana, Laela H. Nurani, and Iis Wahyuningsih. "Enhancement of Icariin Aphrodisiac Effect by Solid-SNEDDS Method Using Shark Liver Oil Phase." Journal of Advanced Zoology 44, no. 3 (2023): 894–902. http://dx.doi.org/10.17762/jaz.v44i3.1189.

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The Epimedium brevicornu Maxim plant contains icariin, a flavonoid compound known for its aphrodisiac effects. However, icariin has low solubility and bioavailability. This study aims to find the best formula for S-SNEDDS icariin, its physical properties, characteristics, and aphrodisiac activity. Using the S-SNEDDS (Solid-Self Nanoemulsifying Drug Delivery System) method with shark liver oil phase is expected to increase the solubility and bioavailability of icariin. The optimum formula used is tween 80 (72.5%): PEG 400 (13.75%) and shark liver oil (13.75%). The optimal formula of S-SNEDDS ic

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Liu, Guo, Ying Yang, Kyung-San Min, Bin-Na Lee, and Yun-Chan Hwang. "Odontogenic Effect of Icariin on the Human Dental Pulp Cells." Medicina 58, no. 3 (2022): 434. http://dx.doi.org/10.3390/medicina58030434.

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Background and Objectives: Human dental pulp cells (HDPCs) can be used for dentin regeneration due to its odontogenic differentiation property. Icariin can induce osteogenic differentiation of stem cells. However, its potential to induce odontogenic differentiation of HDPCs remains unclear. Thus, the aim of this study was to evaluate the capacity of icariin to induce odontogenic differentiation of HDPCs and investigate the underlying molecular mechanism. Materials and Methods: Cell viability assay was used to detect the cytotoxicity of icariin to HDPCs. Effect of icariin on HDPCs chemotaxis wa

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Luo, Wei, Yi Lu, Jun-Hua Deng, et al. "Icariin ameliorates viral myocarditis by inhibiting TLR4-mediated ferroptosis." Asian Pacific Journal of Tropical Biomedicine 14, no. 3 (2024): 106–14. http://dx.doi.org/10.4103/apjtb.apjtb_588_23.

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Objective: To explore the mechanism by which icariin alleviates viral myocarditis. Methods: CVB3-induced cardiomyocytes were used as an in vitro model of viral myocarditis to assess the effects of icariin treatment on cell viability, inflammation, and apoptosis. Moreover, the effects of icariin on ferroptosis and TLR4 signaling were assessed. After AC16 cells were transfected with TLR4 overexpression plasmids, the role of TLR4 in mediating the regulatory effect of icariin in viral myocarditis was investigated. Results: Icariin significantly elevated cell viability and reduced inflammatory fact

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Xiao, Hong-Bo, Guo-Guang Sui, and Xiang-Yang Lu. "Icariin improves eNOS/NO pathway to prohibit the atherogenesis of apolipoprotein E-null mice." Canadian Journal of Physiology and Pharmacology 95, no. 6 (2017): 625–33. http://dx.doi.org/10.1139/cjpp-2016-0367.

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Impaired endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway induces atherogenesis. The present study examined whether icariin improves the eNOS/NO pathway to prohibit the atherogenesis of apolipoprotein E-null (ApoE−/−) mice. In vitro, primary human umbilical vein endothelial cells (HUVECs) were randomly divided into 7 groups: control; vehicle; icariin 10; lyphosphatidylcholine (LPC) group; LPC + icariin 1; LPC + icariin 3; and LPC + icariin 10. In vivo, 80 mice were separated randomly into 4 groups (n = 20): control, ApoE−/−, ApoE−/− + icariin 10, and ApoE−/− + icariin 30. Apo

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Yang, Jin-Xia, Iduna Fichtner, Monika Becker, Margit Lemm, and Xue-Mei Wang. "Anti-Proliferative Efficacy of Icariin on HepG2 Hepatoma and Its Possible Mechanism of Action." American Journal of Chinese Medicine 37, no. 06 (2009): 1153–65. http://dx.doi.org/10.1142/s0192415x09007569.

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The aim of the present work was to explore the anti-hepatoma effects of icariin both in vitro and in vivo and to elucidate its potential mechanism of action. The MTT assay was applied to test the anti-proliferative effects of icariin in vitro. HepG2 bearing NMRI nu/nu mice were used to test the anticancer effects of icariin in vivo. Immunohistochemical assay and flow cytometry assay (FACS) were applied to detect the possible mechanisms of action of icariin. MTT assay illustrated that icariin inhibited the proliferation of HepG2 cells in a concentration dependent manner; meanwhile, icariin inhi

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18

Feng, Zhenyu, Chao Chen, Zhenyu Ye, et al. "The Effect of Icariin on Human Hepatoellular Carcinomas Cell Apoptosis and Cell Cycle Arrest." Journal of Biomaterials and Tissue Engineering 11, no. 12 (2021): 2389–94. http://dx.doi.org/10.1166/jbt.2021.2814.

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Background: Natural products often have novel frameworks and unique mechanisms, It is an important way to develop new anti-tumor drugs.The paper explored the effect of Icariin on HepG2 cell apoptosis and cell cycle arrest. Material and methods: Human liver cancer HepG2 cells were studied. The biological activity of Icariin on HepG2 cells was comprehensively investigated. The mechanism was preliminarily explored from the aspects of proliferation, cell cycle, and apoptosis. Results: Icariin showed significant inhibitory effect on cell proliferation after administration, and the effect was time-a

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Zhao, Chang Fu, Zhen Hua Li, Shao Jun Li, Jian An Li, Ting Ting Hou, and Yang Wang. "PLGA scaffold carrying icariin to inhibit the progression of osteoarthritis in rabbits." Royal Society Open Science 6, no. 4 (2019): 181877. http://dx.doi.org/10.1098/rsos.181877.

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Icariin, the main effective component extracted from epimedium, has been shown to stimulate osteogenic differentiation and bone formation and to increase synthesis of the cartilage extracellular matrix. However, there has been little study on the effects of icariin on osteoarthritis. In this study, we loaded icariin onto poly(lactic-co-glycolic acid) (PLGA) electrospinning. The aim of this study was to explore a composite scaffold and to inhibit the progression of osteoarthritis. Our main experimental results demonstrated that the PLGA/icariin composite spinning scaffold had higher hydrophilic

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Li, Xiao-Feng, Hao Xu, Yong-Jian Zhao та ін. "Icariin Augments Bone Formation and Reverses the Phenotypes of Osteoprotegerin-Deficient Mice through the Activation of Wnt/β-Catenin-BMP Signaling". Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/652317.

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Icariin has been mostly reported to enhance bone fracture healing and treat postmenopausal osteoporosis in ovariectomized animal model. As another novel animal model of osteoporosis, there is few publication about the effect of Icariin on osteoprotegerin-deficient mice. Therefore, the goal of this study is to find the effect on bone formation and underlying mechanisms of Icariin in osteoprotegerin (OPG) knockout (KO) mice. We found that Icariin significantly stimulated new bone formation after local injection over the surface of calvaria at the dose of 5 mg/kg per day. With this dose, Icariin

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Cao, Yun-Feng, Rong-Rong He, Jun Cao, Jian-Xing Chen, Ting Huang, and Yong Liu. "Drug-Drug Interactions Potential of Icariin and Its Intestinal Metabolites via Inhibition of Intestinal UDP-Glucuronosyltransferases." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/395912.

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Icariin is known as an indicative constituent of theEpimediumgenus, which has been commonly used in Chinese herbal medicine to enhance treat impotence and improve sexual function, as well as for several other indications for over 2000 years. In this study, we aimed to investigate the effects of icariin and its intestinal metabolites on the activities of human UDP-glucuronosyltransferase (UGT) activities. Using a panel of recombinant human UGT isoforms, we found that icariin exhibited potent inhibition against UGT1A3. It is interesting that the intestinal metabolites of icariin exhibited a diff

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Chi, Liqun, Wenyuan Gao, Xiangrong Shu, and Xin Lu. "A Natural Flavonoid Glucoside, Icariin, Regulates Th17 and Alleviates Rheumatoid Arthritis in a Murine Model." Mediators of Inflammation 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/392062.

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Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that causes deformity of the joints and physical disability. Icariin, a natural flavonoid glucoside isolated from plants in theEpimediumfamily, has been proven to have various pharmacological activities. A recent study showed that icariin suppressed cartilage and bone degradation in mice of collagen-induced arthritis. However, the mechanism needs to be further investigated. In our current study, we found that icariin reduced the arthritis score and the incidence of arthritis compared with that in mice treated with water. Ic

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Brown, E. Sherwood, Collette Bice, William C. Putnam, et al. "Human Safety and Pharmacokinetics Study of Orally Administered Icariin: Randomized, Double-Blind, Placebo-Controlled Trial." Natural Product Communications 14, no. 6 (2019): 1934578X1985678. http://dx.doi.org/10.1177/1934578x19856789.

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Preclinical literature suggests that icariin, a flavonoid found in Epimedium, may have potential for medical and psychiatric conditions. The objective of this study was to examine the safety, tolerability, and pharmacokinetics of orally administered icariin at doses of 100 to 1,680 mg/day in 24 healthy adult participants. Cognition, mood, and side effects were assessed over 5 days. Multiple blood samples were obtained over 24 hours to assess bioavailability and pharmacokinetics. Data were analyzed using a Wilcoxon signed rank test and Mann-Whitney U test. At all doses, either very low or undet

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Qi, Shanshan, Jia He, Hongxing Zheng, Chen Chen, and Shiqiang Lan. "Icariin Prevents Diabetes-Induced Bone Loss in Rats by Reducing Blood Glucose and Suppressing Bone Turnover." Molecules 24, no. 10 (2019): 1871. http://dx.doi.org/10.3390/molecules24101871.

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Diabetic Osteoporosis (DOP) is a common metabolic bone disease, characterized by decreased bone mineral density (BMD) and destruction of bone microstructure. It has been reported that icariin is beneficial for estrogen deficiency-induced osteoporosis, and alcohol-induced osteoporosis; whether icariin has protective effects on diabetes-induced osteoporosis has not been reported. In this study, a rat model of diabetic osteoporosis was established by streptozotocin injection, the bone protective effects and potential mechanism of icariin on diabetes-induced bone loss was observed. Thirty 8-week-o

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Huang, Jie, Lei Zhang, and Zhongxin Zhou. "309 Effects of dietary supplying icariin on the bone metabolism and the laying performance in caged laying hens." Journal of Animal Science 97, Supplement_3 (2019): 11. http://dx.doi.org/10.1093/jas/skz258.020.

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Abstract Icariin, a flavonol glycoside, is one of major active ingredients of the traditional Chinese medicine Herba epimedii. Icariin has been reported to successfully treat the osteoporosis of the rat. However, effects of icariin on the osteoporosis in caged laying hens are still unkown. This study present the effects of dietary icariin supplementation on the laying performance, the egg quality and the bone metabolism in caged laying hens. A total of 216 Lohmann pink-shell laying hens of 54-week-old from a commercial farm in the Hubei province of China were randomly assigned to 3 treatment g

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Kou, Yuhui, Zhiyong Wang, Zhihong Wu, et al. "EpimediumExtract Promotes Peripheral Nerve Regeneration in Rats." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/954798.

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Effects ofEpimediumextract and its constituent icariin on peripheral nerve repair were investigated in a crush injury rat model. Animals were divided into four groups: sham, control,Epimediumextract, and icariin groups. At postoperative weeks 1, 2, 4, and 8, nerve regeneration and functional recovery were evaluated by sciatic functional index (SFI), nerve electrophysiology, nerve pinch test, and muscle wet weight. Results showed that at 2 and 4 weeks after surgery rats in theEpimediumgroup displayed a better recovery of nerve function than that in the icariin and control groups, with better re

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Zhang, Dongdong, Zhe Wang, Chenxia Sheng, et al. "Icariin Prevents Amyloid Beta-Induced Apoptosis via the PI3K/Akt Pathway in PC-12 Cells." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/235265.

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Icariin is a prenylated flavonol glycoside derived from the Chinese herbEpimedium sagittatumthat exerts a variety of pharmacological activities and shows promise in the treatment and prevention of Alzheimer’s disease. In this study, we investigated the neuroprotective effects of icariin against amyloid beta protein fragment 25–35 (Aβ25–35) induced neurotoxicity in cultured rat pheochromocytoma PC12 cells and explored potential underlying mechanisms. Our results showed that icariin dose-dependently increased cell viability and decreasedAβ25–35-induced apoptosis, as assessed by MTT assay and Ann

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Li, Yusheng, Juntao Zhang, Aifeng Liu, et al. "Icariin: A Potential Lipid Metabolism Regulator in Osteoarthritis." Natural Product Communications 17, no. 9 (2022): 1934578X2211260. http://dx.doi.org/10.1177/1934578x221126046.

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Background: Icariin is a small molecule drug capable of treating osteoarthritis. Additionally, icariin is known to have an excellent ability to regulate lipid metabolism. A growing number of studies have demonstrated that lipid metabolism is related to the pathogenesis of osteoarthritis. Therefore, by regulating lipid metabolism, icariin may have a significant role in osteoarthritis. However, the molecular mechanism by which icariin regulates lipid metabolism in osteoarthritis is currently unknown. Understanding the molecular mechanism would be helpful in the treatment of osteoarthritis. Objec

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Jiyun, L., T. Zai, and S. J. Hopkins. "Icariin." Drugs of the Future 23, no. 2 (1998): 142. http://dx.doi.org/10.1358/dof.1998.023.02.445639.

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Zhang, Yibing, Dongsheng Xu, Peng Huang та ін. "Essential role of protein kinase C βI in icariin-mediated protection against atherosclerosis". Journal of Pharmacy and Pharmacology 73, № 9 (2021): 1169–79. http://dx.doi.org/10.1093/jpp/rgab040.

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Abstract Objectives This study aimed to clarify the superior beneficial effects of icariin on atherosclerosis, as well as to explore the possible underlying mechanisms for its effect via the modulation of protein kinase C βI. Methods Lipid profiles were determined while dissected aortas were prepared of ApoE−/− mice. The expression of protein kinase C βI and phosphorylation of protein kinase C βI were determined by immunohistochemistry analysis. Human vascular smooth muscle cells were subjected to ox-LDL stimulation. MTS assay was conducted to detect cell proliferation. A transwell migration a

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Joo, Hyejin, Jinhyun Bae, Jun-Seon Lee, et al. "Icariin Improves Functional Behavior in a Mouse Model of Traumatic Brain Injury and Promotes Synaptic Plasticity Markers." Planta Medica 85, no. 03 (2018): 231–38. http://dx.doi.org/10.1055/a-0753-0400.

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AbstractEpimedii Herba (EH) has been used in traditional Asian medicine to treat hemiplegia following stroke. Icariin, its major active component, is used as a quality-control marker and for its various pharmacological effects. We hypothesized that icariin would show protective effects following traumatic brain injury (TBI). The TBI mouse model was induced using a controlled cortical impact method. Body weight, brain damage, motor function, and cognitive function were evaluated. Synaptogenesis markers were analyzed to investigate potential mechanisms of action. The animals were divided into si

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Liu, Tianlin, Xin Zhang, Yuan Luo, Yuanliang Huang, and Gang Wu. "Slowly Delivered Icariin/Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells to Promote the Healing of Calvarial Critical-Size Bone Defects." Stem Cells International 2016 (2016): 1–13. http://dx.doi.org/10.1155/2016/1416047.

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Bone tissue engineering technique is a promising strategy to repair large-volume bone defects. In this study, we developed a 3-dimensional construct by combining icariin (a small-molecule Chinese medicine), allogeneic bone marrow-derived mesenchymal stem cells (BMSCs), and a siliceous mesostructured cellular foams-poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (SMC-PHBHHx) composite scaffold. We hypothesized that the slowly released icariin could significantly promote the efficacy of SMC-PHBHHx/allogeneic BMSCs for repairing critical-size bone defects in rats. In in vitro cellular experiments,

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Zhang, Guoying, Xiaofei Cheng, Gongshe Zhou, Huimin Xue, Shan Shao, and Zheng Wang. "New pathway of icariin-induced MSC osteogenesis: transcriptional activation of TAZ/Runx2 by PI3K/Akt." Open Life Sciences 12, no. 1 (2017): 228–36. http://dx.doi.org/10.1515/biol-2017-0027.

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AbstractIcariin has been demonstrated to stimulate mesenchymal stem cell (MSC) osteogensis and activate several signals, such as PI3K/Akt, but how the osteogenesis was sequentially mediated is unclear. Runx2 is one of the osteogenic regulators in MSC and is regulated by the TAZ gene. The purpose of this study was to investigate whether icariin-activated PI3K/Akt crosstalked with the TAZ-Runx2 pathway to regulate MSC osteogenesis. Adipose-derived MSCs were treated with icariin alone, together with TAZ silencing or PI3K/Akt inhibitor. Normal MSCs were used as a control. The activation of PI3K/Ak

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Deng, Xiangyu, Sheng Chen, Dong Zheng, Zengwu Shao, Hang Liang, and Hongzhi Hu. "Icariin Prevents H2O2-Induced Apoptosis via the PI3K/Akt Pathway in Rat Nucleus Pulposus Intervertebral Disc Cells." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/2694261.

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Icariin is a prenylated flavonol glycoside derived from the Chinese herb Epimedium sagittatum. This study investigated the mechanism by which icariin prevents H2O2-induced apoptosis in rat nucleus pulposus (NP) cells. NP cells were isolated from the rat intervertebral disc and they were divided into five groups after 3 passages: (A) blank control; (B) 200 μM H2O2; (C) 200 μM H2O2 + 20 μM icariin; (D) 20 μM icariin + 200 μM H2O2 + 25 μM LY294002; (E) 200 μM H2O2 + 25 μM LY294002. LY294002 is a selective inhibitor of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. NP cell viability,

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Huang, Jun-ming, Yuan Bao, Wei Xiang, et al. "Icariin Regulates the Bidirectional Differentiation of Bone Marrow Mesenchymal Stem Cells through Canonical Wnt Signaling Pathway." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/8085325.

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Fat infiltration within the bone marrow is easily observed in some postmenopausal women. Those fats are mainly derived from bone marrow mesenchymal stem cells (BMMSCs). The increment of adipocytes derived from BMMSCs leads to decreased osteoblasts derived from BMMSCs, so the bidirectional differentiation of BMMSCs significantly contributes to osteoporosis. Icariin is the main extractive of Herba Epimedii which is widely used in traditional Chinese medicine. In this experiment, we investigated the effect of icariin on the bidirectional differentiation of BMMSCs through quantitative real-time PC

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Soh, H., S. Park, H. J. Lee, S. J. Koh, J. P. Im, and J. S. Kim. "P104 Icariin Attenuates Intestinal Inflammation through Inhibition of the Nuclear Factor-ĸB signaling." Journal of Crohn's and Colitis 16, Supplement_1 (2022): i199—i200. http://dx.doi.org/10.1093/ecco-jcc/jjab232.232.

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Abstract Background Icariin is a natural flavonoid glucoside from plants in Epimedium family, known to have anti-oxidative and anti-inflammatory activities. This study investigated the effects of Icariin on nuclear factor-kappa B (NF-ĸB) signaling pathway in intestinal epithelial cells (IEC) and macrophages, and in acute and chronic murine colitis models. Methods Human IEC line COLO 205 and murine macrophage cell line RAW 264.7 were pretreated with Icariin and then stimulated with tumor necrosis factor-α (TNF-α) and lipopolysaccharide respectively for in vitro studies. The expression of pro- a

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Zhang, Yibing, Xiaoyan Ma, Xiangjun Li, Tong Zhang, Meng Qin, and Liqun Ren. "Effects of Icariin on Atherosclerosis and Predicted Function Regulatory Network in ApoE Deficient Mice." BioMed Research International 2018 (November 6, 2018): 1–12. http://dx.doi.org/10.1155/2018/9424186.

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Objective. Icariin plays a pivotal role in ameliorating atherosclerosis for animal models although its comprehensive biological role remains largely unexplored. This study aimed to fully understand the effects of icariin on atherosclerosis in high-fat diet-induced ApoE-/- mice and investigate mRNA-miRNA regulation based on microarray and bioinformatics analysis. Methods. The areas of atherosclerotic lesions in en face aorta were evaluated. Microarray analysis was performed on atherosclerotic aortic tissues. The integrative analysis of mRNA and miRNA profiling was utilized to suggest specific f

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Zhang, Hui, Khalid Mehmood, Xiong Jiang, et al. "Effect of Icariin on Tibial Dyschondroplasia Incidence and Tibial Characteristics by Regulating P2RX7 in Chickens." BioMed Research International 2018 (2018): 1–11. http://dx.doi.org/10.1155/2018/6796271.

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Tibial dyschondroplasia (TD) is a disease of rapid growing chickens that occurs in many avian species; it is characterized by nonvascular and nonmineralized growth plates, along with tibia bone deformation and lameness. Icariin is widely used to treat bone diseases in humans, but no report is available regarding the effectiveness of icariin against avian TD. Therefore, this study was designed to determine its effect against TD. For this purpose, a total of 180 broiler chicks were distributed into three groups including control, TD, and icariin group. Control group was given a standard normal d

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Xu, Shunjun, Jiejing Yu, Jingjing Zhan, Liu Yang, Longgang Guo, and Yijuan Xu. "Pharmacokinetics, Tissue Distribution, and Metabolism Study of Icariin in Rat." BioMed Research International 2017 (2017): 1–17. http://dx.doi.org/10.1155/2017/4684962.

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Icariin is one of the predominant flavonoids contained in Herba Epimedii (Yin-yang-huo in Chinese), a well-known Chinese medicine for the treatment of cancers and immune system diseases. Although Herba Epimedii has been widely used in China and there are so many and various research reports on the herbal drug and its main flavones, very limited data is available on the tissue distribution and biotransformation of icariin. In the present study, a liquid chromatographic method combined with electrospray ionization tandem mass spectrometry was developed to quantify the concentration of icariin in

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Choi, Jiwon, Hyewon Choi, and Jayong Chung. "Icariin Supplementation Suppresses the Markers of Ferroptosis and Attenuates the Progression of Nonalcoholic Steatohepatitis in Mice Fed a Methionine Choline-Deficient Diet." International Journal of Molecular Sciences 24, no. 15 (2023): 12510. http://dx.doi.org/10.3390/ijms241512510.

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Icariin, a flavonoid abundant in the herb Epimedium, exhibits anti-ferroptotic activity. However, its impact on nonalcoholic steatohepatitis (NASH) development remains unclear. This study aimed to investigate the potential role of icariin in mitigating methionine choline-deficient (MCD) diet-induced NASH in C57BL/6J mice. The results showed that icariin treatment significantly reduced serum alanine aminotrasferase and aspartate aminotransferase activities while improving steatosis, inflammation, ballooning, and fibrosis in the liver tissues of mice fed the MCD diet. These improvements were acc

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Duan, Ping, Jing Cheng, Ruotong Mao, Ruina Wang, Yueqi Jin, and Chunyang Li. "Icariin-Mediated miR-875-5p Inhibits Autophagy and Epithelial-Mesenchymal Transition by Regulation of MDM4 in Cervical Cancer." Journal of Biomedical Nanotechnology 18, no. 12 (2022): 2708–20. http://dx.doi.org/10.1166/jbn.2022.3472.

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MicroRNAs, one type of non-coding RNA, and Icariin have attracted tremendous attention concerning various diseases, especially cancers. Also, the function of Icariin on malignant behaviors by targeting miR-875-5p/MDM4 axis in cervical cancer remains unknown. MiR-875-5p analogs combined with MDM4 or Icariin were used to explore autophagy and epithelial-mesenchymal transition in cancer cells. Xenograft mice were highlighted to elucidate the influences of Icariin and miR-875-5p in vivo. As a result, miR-875-5p was cut down in cervical cancer cells, which promoted malignant phenotype, autophagy, a

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Swann, Brian. "Icarian, and: After the Storm." Prairie Schooner 78, no. 2 (2004): 65–66. http://dx.doi.org/10.1353/psg.2004.0098.

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Dong, Mengqian, Ying Jin, Peifen Huang, and Zhiyang Chen. "Effects of icariin and quercetin on high glucose-induced neuronal cell apoptosis." Tropical Journal of Pharmaceutical Research 19, no. 6 (2020): 1185–90. http://dx.doi.org/10.4314/tjpr.v19i6.10.

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Purpose: To study the effects of icariin and quercetin on cell apoptotic changes in neurons induced by elevated glucose condition, and the mechanism involved. Methods: Neonatal male Sprague Dawley rats (n = 48) weighing 5 – 7 g were used. Neuronal cells were isolated from rat hippocampus and cultured after purification. The cells were randomly assigned to six groups: control, high glucose, icariin, quercetin, serine/threonine-specific protein kinase (Akt) inhibitor, and Akt agonist groups. The Akt inhibitor and agonist used in this study were MK-22062hci and SC79, respectively. The influ

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Xie, Jiao, Kanghuai Zhang, Haitao Wang, et al. "Determination of the Solubility, Dissolution Enthalpy, and Entropy of Icariin in Acetone, Acetoacetate, Chloroform, and Light Petroleum." Natural Product Communications 15, no. 11 (2020): 1934578X2097149. http://dx.doi.org/10.1177/1934578x20971491.

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The solubility of icariin in acetone, acetoacetate, chloroform, and light petroleum in the 283.2‐318.2 K range was measured by ultraviolet-visible spectrophotometry. As the temperature increased, the solubility of icariin in the 4 solvents gradually increased. The solubility data correlated with the modified Apelblat equation. The dissolution enthalpy and entropy of icariin were determined using van’t Hoff plots. The dissolution enthalpy and entropy of icariin in the 4 solvents increases as acetone >acetoacetate >chloroform >light petroleum, which can be explained by the difference of

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Peris, María Cardells, Alba Martínez, Marina Pascual Ortíz, Chirag C. Sheth, and Veronica Veses. "Icariin in Combination with Amoxycillin-Clavulanate and Ampicillin, but Not Vancomycin, Increases Antibiotic Sensitivity and Growth Inhibition against Methicillin-Resistant Staphylococcus aureus." Antibiotics 11, no. 2 (2022): 233. http://dx.doi.org/10.3390/antibiotics11020233.

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The widespread irrational use of antibiotics in recent years has resulted in an increase in the detection of multi-resistant bacterial strains, particularly methicillin-resistant Staphylococcus aureus (MRSA). The use of natural derivatives such as flavonoids is postulated as one of the most promising avenues to solve this emerging public health problem. The objective of the present study is to characterize the antimicrobial activity of icariin, a flavonoid compound isolated from a variety of plants of the Epimedium genus, against human and animal clinical MRSA isolates. Our study found that ic

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Wang, Xu-Yun, Wen-Jing Xu, Bo-Nan Li, Tian-Song Sun, and Wen Sheng. "Icariin plus curcumol enhances autophagy through the mTOR pathway and promotes cathepsin B-mediated pyroptosis of prostate cancer cells." Asian Pacific Journal of Tropical Biomedicine 14, no. 2 (2024): 55–64. http://dx.doi.org/10.4103/apjtb.apjtb_649_23.

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Objective: To examine the effect of icariin plus curcumol on prostate cancer cells PC3 and elucidate the underlying mechanisms. Methods: We employed the Cell Counting Kit 8 assay and colony formation assay to assess cell viability and proliferation. Autophagy expression was analyzed using monodansylcadaverine staining. Immunofluorescence and Western blot analyses were used to evaluate protein expressions related to autophagy, pyroptosis, and the mTOR pathway. Cellular damage was examined using the lactate dehydrogenase assay. Moreover, cathepsin B and NLRP3 were detected by co-immunoprecipitat

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Duan, Shuwen, Zhaoran Ding, Can Liu, Xiaohui Wang, and Enlai Dai. "Icariin suppresses nephrotic syndrome by inhibiting pyroptosis and epithelial-to-mesenchymal transition." PLOS ONE 19, no. 7 (2024): e0298353. http://dx.doi.org/10.1371/journal.pone.0298353.

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Context Nephrotic syndrome(NS) has emerged as a worldwide public health problem. Renal fibrosis is the most common pathological change from NS to end-stage renal failure, seriously affecting the prognosis of renal disease. Although tremendous efforts have been made to treat NS, specific drug therapies to delay the progression of NS toward end-stage renal failure are limited. Epimedium is generally used to treat kidney disease in traditional Chinese medicine. Icariin is a principal active component of Epimedium. Methods We used Sprague Dawley rats to establish NS models by injecting doxorubicin

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Sun, Si, Le Liu, Xiaojun Tian, et al. "Icariin Attenuates High Glucose-Induced Apoptosis, Oxidative Stress, and Inflammation in Human Umbilical Venous Endothelial Cells." Planta Medica 85, no. 06 (2019): 473–82. http://dx.doi.org/10.1055/a-0837-0975.

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AbstractEndothelial dysfunction is closely associated with diabetic complications. Icariin, a flavonoid glycoside isolated from the Epimedium plant species, exhibits antidiabetic properties. However, its impact on endothelial function remains poorly understood, particularly under hyperglycemia. In this study, we investigated the potential protective effect of icariin on high glucose-induced detrimental effects on vascular endothelial cells. Human umbilical venous endothelial cells were incubated in media containing 5.5 mM glucose (normal glucose) or 25 mM glucose (high glucose) in the presence

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Hai, Yang, Ling Zuo, Meng Wang, et al. "Icariin Alleviates Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome by Improving Liver Fatty Acid Oxidation and Inhibiting Lipid Accumulation." Molecules 28, no. 2 (2023): 517. http://dx.doi.org/10.3390/molecules28020517.

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(1) Background: Icariin is the main component of the Chinese herb Epimedium. A number of studies have shown that it alleviates abnormal lipid metabolism. However, it is not clear whether and how icariin can ameliorate hepatic steatosis with polycystic ovary syndrome (PCOS). This study was designed to explore the anti-hepatosteatosis effect of icariin in rats with polycystic ovary syndrome. (2) Methods: Female Sprague Dawley(SD)rats were treated with a high-fat diet and letrozole for 21 days to make nonalcoholic fatty liver disease (NAFLD) in the polycystic ovary syndrome model. Then model rats

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Huang, Mi, Ying Wang, and Rui Peng. "Icariin Alleviates Glucocorticoid-Induced Osteoporosis through EphB4/Ephrin-B2 Axis." Evidence-Based Complementary and Alternative Medicine 2020 (May 18, 2020): 1–8. http://dx.doi.org/10.1155/2020/2982480.

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Purpose. Glucocorticoid (GC) is the most important risk factor for osteoporosis (OP); in the present study, we examined the potential mechanism of icariin, a natural bioactive compound isolated from the traditional Chinese herbal Epimedium, for GC-induced OP to explore its potential therapeutic effect. Methods. We used a GC-induced OP mice model and treated with icariin. Pathological changes were measured by H&E staining, and the effects of icariin on osteoblasts and osteoclasts were measured by immunohistochemistry (IHC) staining and western blot (WB) analyses, while trabecular bone param

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