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Mermans, J. F., S. M. Ghasemi, B. I. Lissenberg-Witte, and J. P. W. Don Griot. "The Reproducibility of the Jaw Index in the Measurement of Healthy Newborns." Cleft Palate-Craniofacial Journal 57, no. 5 (November 21, 2019): 574–80. http://dx.doi.org/10.1177/1055665619885726.
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Objective: Establish the reliability of the jaw index to objectify the relationship between the maxilla and mandible in healthy newborns. Design: Cohort study. Setting: Tertiary setting. Patients: A total of 52 healthy newborns were included to detect an inter and intraclass correlation coefficient (ICC) of 0.8 with a 95% confidence interval (95% CI) of width 0.3. Inclusion criteria were children born full term without respiratory or feeding problems, and without congenital malformations or facial deformities due to birth trauma. Uncooperative patients were excluded. Interventions: The jaw index, a measuring tool for objectifying micrognathia in children suspected of having Robin sequence, was used. An ICC of greater than 0.8 was considered clinically relevant. Main Outcome Measure(s): Primary outcomes are the reliability of the jaw index expressed as interclass correlation coefficient and ICC. Secondary outcomes are the mean jaw index and mean length of the mandible, maxilla, and the alveolar overjet. Results: An interclass correlation coefficient of 0.74 (95% CI: 0.49-0.86) and an ICC of 0.81 (95% CI: 0.66-0.89) were found. The mandible had an average length of 162.6 mm (standard deviation [SD] 11.1), the maxilla 168.7 mm (SD 9.4), the alveolar overjet 2.0 mm (SD 0.60), and the mean jaw index was 2.1 (SD 0.64). Conclusion: The jaw index is a consistent instrument between different observers as well as for one observer measuring consecutively in the same child, to objectify the size of the lower jaw compared to that of the upper jaw in healthy newborns.
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ชุมพล, จิรวดี, ศศิธร กาญจนสุวรรณ, ธนภรณ์ แดงใจ, and ปณิธี พูนเพชรรัตน์. "การพัฒนาแบบประเมินรายงานกรณีศึกษาผู้ป่วยและครอบครัวที่มีปัญหาสุขภาพซับซ้อนที่พบในเวชปฏิบัติปฐมภูมิ." Ramathibodi Medical Journal 45, no. 4 (December 28, 2022): 35–44. http://dx.doi.org/10.33165/rmj.2022.45.4.259391.
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บทนำ: การเขียนรายงานกรณีศึกษาผู้ป่วยและครอบครัวที่มีปัญหาสุขภาพซับซ้อนที่พบในเวชปฏิบัติปฐมภูมิของนักศึกษาแพทย์ชั้นปีที่ 6 ควรมีแบบประเมินที่สามารถใช้ในการตรวจรายงานได้อย่างมีประสิทธิภาพและมีความยุติธรรมต่อผู้เรียน วัตถุประสงค์: เพื่อพัฒนาและตรวจสอบคุณภาพแบบประเมินรายงานจากกรณีศึกษาผู้ป่วยและครอบครัวที่มีปัญหาสุขภาพซับซ้อนที่พบในเวชปฏิบัติปฐมภูมิ วิธีการศึกษา: สร้างแบบประเมินในหัวข้อที่ต้องการตามขั้นตอนแล้วนำแบบประเมินไปใช้ประเมินรายงานของนักศึกษาแพทย์ชั้นปีที่ 6 จำนวน 15 กลุ่ม ในรายวิชาเวชศาสตร์ครอบครัวและเวชศาสตร์ชุมชน (รหัสรายวิชา รมคร 615) ปีการศึกษา 2564 คณะแพทยศาสตร์โรงพยาบาลรามาธิบดี มหาวิทยาลัยมหิดล ประเมินโดยอาจารย์แพทย์ที่เลือกมาแบบเจาะจง จำนวน 3 คน และตรวจสอบความเที่ยงตรงและความเชื่อมั่นของแบบประเมิน ผลการศึกษา: แบบประเมินรายงานกรณีศึกษาผู้ป่วยและครอบครัวที่มีปัญหาสุขภาพซับซ้อนที่พบในเวชปฏิบัติปฐมภูมิ เป็นแบบประเมินแบบรูบริคหรือเกณฑ์การให้คะแนน แบบวิเคราะห์ย่อย มีหัวข้อการประเมิน 10 หัวข้อ ระดับเกณฑ์การให้คะแนน 3 ระดับ มีค่าดัชนีความสอดคล้อง (Index of congruence, IOC) ระหว่าง 0.67 ถึง 1.00 ค่าความเชื่อมั่นของเครื่องมือจากดัชนีความสอดคล้องระหว่างผู้ตรวจ (Inter-rater reliability, IRR) ด้วยการใช้สัมประสิทธิ์สัมพันธ์ภายในชั้น (Interclass correlation coefficient, ICC) อยู่ในระดับพอใช้ สรุป: แบบประเมินรายงานแบบรูบริคหรือเกณฑ์การให้คะแนนมีคุณภาพสามารถนำไปใช้ได้ อย่างไรก็ตาม ความเข้าใจในแบบประเมินส่งผลต่อคุณภาพของแบบประเมิน
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Harrell, M. D., N. R. Dobson, C. Olsen, A. Ahmed, and C. E. Hunt. "Inpatient comparison of wireless and wired pulse oximetry in neonates." Journal of Neonatal-Perinatal Medicine 15, no. 2 (April 12, 2022): 283–89. http://dx.doi.org/10.3233/npm-210836.
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BACKGROUND: To compare oxygen saturation (SpO2) and heart rate (HR) recorded by a reference wired pulse oximeter to a wireless pulse oximeter in inpatient neonates. METHODS: Term infants born≥37 + 0 weeks and preterm infants born≤35 + 0 weeks gestation were enrolled and time-matched data pairs were obtained. The primary outcome was intraclass correlation coefficient and r-values between the two oximeters for heart rate and oxygen saturation. RESULTS: Thirty term and 20 preterm neonates were enrolled. There was a high degree of correlation between the two oximeters for HR (r = 0.926) among all 50 infants, and excellent interclass correlation (ICC = 0.961), but there were no bradycardia episodes in either term or preterm infants. There was a lesser degree of correlation for SpO2 values in the term and preterm groups (r = 0.242; 0.521, respectively) along with moderate interclass correlation (ICC = 0.719) but few episodes of hypoxemia≤90% occurred in enrolled subjects. CONCLUSIONS: There were no significant differences between the wireless and reference wired oximeters for assessing HR. There was less correlation between the two oximeters for monitoring SpO2 in both the term and preterm group. Wireless pulse oximetry may have practical advantages for use in inpatient neonates, but additional studies are needed that include bradycardia and desaturation events to delineate this question.
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Setiawan, Budi, Ulfah Restu Nugraheni, and Muji Rahayu. "Vacutainer serum separator sebagai alternatif tabung penampung darah pada pemeriksaan kadar ureum." JOURNAL OF MUHAMMADIYAH MEDICAL LABORATORY TECHNOLOGIST 4, no. 1 (June 19, 2021): 81. http://dx.doi.org/10.30651/jmlt.v4i1.7447.
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ABSTRACT Serum using is preferred for urea level because it does not use anticoagulants which can interfere with activity and reaction to the results. The tubes that are widely used to collect blood into serum are vacutainer serum separator and vacutainer plain.This researche aims to determine the degree of agreement s between vacutainer serum separator and vacutainer plain usage on serum urea level result.This research was cross sectional design and hold on October 2020 with subject were taken from thirty blood samples of health analyst students which taken randomly and had no history of disease or kidney function disorder. Each student was taken 6 ml of blood drawn using a venoject with each vacutainer containing 3 ml, so we had 60 data. The data were analyzed by descriptively and inferentially using the Interclass Correlation Coefficient (ICC) statistical test. From the descriptive analysis, the difference in mean levels was 0.35 mg/dL and the ICC statistical test resulted in a degree of agreement 0.745. The data were analyzed by descriptively and inferentially using the Interclass Correlation Coefficient (ICC) statistical test. From the descriptive analysis, the difference in mean levels was 0.35 mg/dL and the ICC statistical test resulted in a degree of agreement was 0.745. The calculation of the average working time between the vacutainer serum separator and the vacutainer plain was 4 minutes 38 seconds and 35 minutes 58 seconds. The analysis concluded that the vacutainer serum separator and the vacutainer plain could be used as an alternative of blood collecting tubes for urea level testing which proved to be no significant difference in the results from this research. Keywords : Urea level, Vacutainer Serum Separator, Vacutainer Plain
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Paiva, Mateus Ramos, Roberto Zambelli de Almeida Pinto, João Murilo Brandão Magalhães, Fernando Araújo Silva Lopes, Rodrigo Simões Castilho, and Daniel Soares Baumfeld. "What is the best approach to evaluating the reduction of the syndesmosis?" Scientific Journal of the Foot & Ankle 12, no. 2 (June 30, 2018): 154–58. http://dx.doi.org/10.30795/scijfootankle.2018.v12.792.
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Objective: To evaluate the reliability, reproducibility, and intra- and interobserver correlation of eight tomographic methods used for assessing the reduction of the syndesmosis in high fractures of the fibula.Methods: A total of seven patients were selected. Eight tomographic methods of measurement were used in the axial plane of the ankle at 1cm proximal to the articular surface. Three orthopaedists from the surgical team were chosen to evaluate the reliability and reproducibility of the measurements. Preoperative and postoperative tomography was used, and measurements were made at two distinct time points, with an interval of 2 months between them. All correlations were assessed using the interclass correlation coefficient (ICC). Results: Method 3 (Zwipp) had ICC values >0.75 (excellent) in all measures by all examiners. Method 4 (Phisitkul) presented ICC values >0.95 (excellent) for the interobserver comparisons at the two time points. In the intraobserver comparison, method 4 had an ICC of 0.49 (satisfactory) in two preoperative evaluations, and the other comparisons presented an ICC >0.76 (excellent). Conclusion: The Zwipp and Phisitkul measurements presented high reliability and reproducibility and are useful for evaluating rotational andtranslational movements of the fibula at the level of the syndesmosis, respectively.
Level of Evidence III; Therapeutic Studies; Comparative Retrospective Study.
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Carneiro, Paula Rossi, Bárbara dos Santos Cardoso, Caroline Modesto da Cunha, and Lídia Cristina da Silva Teles. "Reliability intra-and inter-examiner of the head postural assessment by computerized photogrammetry." Fisioterapia e Pesquisa 21, no. 1 (March 2014): 34–39. http://dx.doi.org/10.1590/1809-2950/402210114.
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Scientific articles about reliability of photogrammetry for cervical spine posture evaluation are infrequent. The aim of the present investigation is to verify intra-and inter-examiner reliability of the computerized photogrammetry method for head postural evaluation in lateral view. Twenty-five young women, between 20 and 30 years old, were positioned seated in an upright position and photographed in lateral view. The photographs were imported to Corel Draw X13 program for postural evaluation by computerized photogrammetry. Analyses of intra-and inter-examiner reliability were performed for the angles: condyle-acromion (ACA), menton-sternum (AME) and Frankfurt (AF). The photogrammetry was performed by two examiners: EA and EB. For intra-examiner analyses, EA assessed the pictures twice (A1 and A2) for the same angles within 3 months. For the inter-examiner analyses, EB performed the photogrammetry for the same angles (B1) in order to compare with the data from EA. Using the interclass correlation coefficient (ICC) we observed an excellent correlation in the intra-examiner analysis (A1 and A2) for the angles: ACA and AME (both with ICC=1.0); and AF (ICC=0.78). For the inter-examiner analyses between A1 and B1, it was observed: ACA (ICC=0.24), AME (ICC=0.26) and AF (ICC=0.00). For the comparison between A2 and B1, the ICC values were: 0.23; 0.27 and 0.00, respectively for ACA, AME and AF, classified as weak correlations. In conclusion, the photogrammetry is reliable when performed by the same examiner. The inter-examiner assess showed low reliability, what could have been compromised by the reduced experience of the EB in applying the method.
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Viinikainen, Sari, Ilmari Rostila, Philip Green, Paula Asikainen, Mika Helminen, and Tarja Suominen. "The organizational social context in public healthcare as viewed by first-line nursing managers: A cross-sectional study." Nordic Journal of Nursing Research 40, no. 2 (December 3, 2019): 89–96. http://dx.doi.org/10.1177/2057158519878342.
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Different organizational climates and cultures appear within healthcare organizations and vary within their associated subgroups. The healthcare and nursing work environments have been studied from the individualistic perspectives rather than from organizational or nurse managers’ group perspectives. The aim of this cross-sectional study was to examine the differentiation of organizational social contexts in hospitals. The organizational social context (OSC) measurement system was used to assess characteristics of culture, climate and morale. The data have been statistically analyzed using within-group consistency (rwg), ANOVA-based eta-squared values and interclass correlation coefficient (ICC). The results revealed that at the divisional level, the organization’s social context is different.
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Arcuri, Francisco, Fernando Barclay, and Ivan Nacul. "Translation, Cultural Adaptation and Validation of the Simple Shoulder Test to Spanish." Orthopaedic Journal of Sports Medicine 2, no. 12_suppl4 (December 1, 2014): 2325967114S0023. http://dx.doi.org/10.1177/2325967114s00233.
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Background: The validation of widely used scales facilitates the comparison across international patient samples. Objective: The objective was to translate, culturally adapt and validate the Simple Shoulder Test into Argentinian Spanish. Methods: The Simple Shoulder Test was translated from English into Argentinian Spanish by two independent translators, translated back into English and evaluated for accuracy by an expert committee to correct the possible discrepancies. It was then administered to 50 patients with different shoulder conditions.Psycometric properties were analyzed including internal consistency, measured with Cronbach´s Alpha, test-retest reliability at 15 days with the interclass correlation coefficient. Results: The internal consistency, validation, was an Alpha of 0,808, evaluated as good. The test-retest reliability index as measured by intra-class correlation coefficient (ICC) was 0.835, evaluated as excellent. Conclusion: The Simple Shoulder Test translation and it´s cultural adaptation to Argentinian-Spanish demonstrated adequate internal reliability and validity, ultimately allowing for its use in the comparison with international patient samples.
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Dehghani, Sanaz, Fariba Yadegari, Atieh Ashtari, and Akbar Biglarian. "Translation, Cultural Adaptation, and Validation of Psychometric Properties of the Parent Section of Parent-Child Interaction Coding System." Iranian Rehabilitation Journal 19, no. 3 (September 1, 2021): 241–50. http://dx.doi.org/10.32598/irj.19.3.1129.1.
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Objectives: Most of the tests regarding parent-child interaction have dealt with this issue from the emotional-behavioral point of view; however, studying these interactions from a combined verbal-behavioral aspect requires a tool consistent with Iranian culture. Parent-Child interaction coding system–3rd edition (DPICS-III, 2009) is allotted to evaluate parent-child interaction. This study was conducted on mothers of 3- to 6-year-old children to translate, adapt to the Persian language, and determine the validity and reliability of the parent section of this test. Methods: This research was descriptive-analytic with a non-experimental design. This test was adapted to the Persian language, and its face validity was examined to clarify the items. Moreover, the correlation between live and video observations of 10 mothers and children was evaluated to determine the validity of observations. Later on, the same rater reviewed the videos of 10 mothers—recorded for the correlation between live and video observations—again within a week for intra-rater reliability and verify the credibility of the rater. Moreover, the Spearman and interclass correlation coefficients were used to determine inter-rater reliability. Data analysis was done by calculating ICC, the Pearson correlation coefficient, and the Spearman correlation coefficient. Results: The translation process led to an appropriate version of the test in Persian language. The Pearson and Spearman correlation coefficients were used for analysis. The correlation between live observation and video was significant (P<0.05, 1-0.74=spearman and P>0.05, 0.99-0.83=Pearson). The reliability of intra-rater was also high (P<0.05, 1-0.89=spearman and P>0.05, 0.99-0.87=Pearson). Furthermore, inter-rater reliability was also high (P<0.05, 0.99-0.81=spearman and P<0.05, 1-0.79=ICC). Discussion: According to the study results, the parent section of DPICS is applicable in the Persian language with appropriate validity and reliability. This applicable test is either as live observation or video recording, with no differences.
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Oleksy, Łukasz, Agnieszka Skiba, Iwona Sulowska, Marcin Trębowicz, Bartosz Rukasz, Artur Stolarczyk, Joanna Zyznawska, and Anna Mika. "Assessment of Measurement Reliability for the IPN Test in Cardiac Patients." Journal of Clinical Medicine 9, no. 5 (May 21, 2020): 1552. http://dx.doi.org/10.3390/jcm9051552.
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Cardiological diagnostics use maximal and submaximal tests with increasing load. Maximal stress tests are currently considered the gold standard. The Institut für Prävention und Nachsorge, Cologne (IPN) test may be an alternative when maximal patient load is not indicated. The universality of the test is well-documented in sport, but the reliability of this test is unknown. The aim of this study was to assess between-trial and between-day reliability for parameters assessed by the IPN stress test in cardiological patients.: In a study of 24 patients aged 39 to 79 years with cardiovascular diseases, the IPN cycle ergometer short test was performed (submaximal performance test). The reliability of heart rate, systolic and diastolic pressure, absolute power at submaximal load, relative performance at submaximal load and target heart rate were assessed. Good (Interclass Correlation Coefficient (ICC) values ranged from 0.832 to 0.894) and excellent (ICC values ranged from 0.904 to 0.969) between-trial reliability was noted. Between-day reliability was good (ICC values from 0.777 to 0.895) and excellent (ICC values from 0.922 to 0.950). The obtained results suggest that the IPN test may be a reliable tool for use in the assessment of cardiological patients, avoiding the implementation of maximal efforts when excessive patient load is not recommended.
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Maister, Nicholas J., Andrew Hely, Liam G. Twycross, Stephen D. Gill, and Richard S. Page. "A New Method for Measuring Glenoid Version on Standard Magnetic Resonance Imaging." Journal of Shoulder and Elbow Arthroplasty 4 (January 2020): 247154922092682. http://dx.doi.org/10.1177/2471549220926826.
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Background The most effective method and modality for measuring glenoid version for different shoulder conditions is uncertain. Computed tomography (CT) imaging exposes the patient to radiation, and standard magnetic resonance imaging (MRI) does not consistently image the entire scapula. This study investigates the reliability of a new method for assessing glenoid version using routine shoulder MRI. Methods MRI images of 20 patients undergoing arthroscopy for shoulder instability were independently assessed by 3 clinicians for osseous and chondrolabral glenoid version. To assess glenoid version, a line was drawn from medial corner of the glenoid body to midpoint of the glenoid face. A line perpendicular to this was the reference against which to measure glenoid version. Measurements were repeated after 3 months to assess intra- and interobserver reliability. Reliability was determined using intraclass correlation coefficients (ICCs). Results Interclass correlation coefficients showed at least good reliability for most estimates of intraobserver reliability (ICC ≥ .66) and excellent reliability for most estimates of interobserver reliability (ICC ≥ .84), with the exception of some inferior glenoid measurements where ICC was poor (ICC ≤.41). Discussion We propose that this new method of measuring glenoid on standard axial MRI can be used as a simple, practical, and reliable method in shoulder instability patients, which will reduce the requirement for CT in this group.
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Buiter, Hans J. C., Floris H. P. van Velden, Josée E. Leysen, Abraham Fisher, Albert D. Windhorst, Adriaan A. Lammertsma, and Marc C. Huisman. "Reproducible Analysis of Rat Brain PET Studies Using an Additional [18F]NaF Scan and an MR-Based ROI Template." International Journal of Molecular Imaging 2012 (September 23, 2012): 1–10. http://dx.doi.org/10.1155/2012/580717.
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Background. An important step in the analysis of positron emission tomography (PET) studies of the brain is the definition of regions of interest (ROI). Image coregistration, ROI analysis, and quantification of brain PET data in small animals can be observer dependent. The purpose of this study was to investigate the feasibility of ROI analysis based on a standard MR template and an additional [18F]NaF scan. Methods. [18F]NaF scans of 10 Wistar rats were coregistered with a standard MR template by 3 observers and derived transformation matrices were applied to corresponding [11C]AF150(S) images. Uptake measures were derived for several brain regions delineated using the MR template. Overall agreement between the 3 observers was assessed by interclass correlation coefficients (ICC) of uptake data. In addition, [11C]AF150(S) ROI data were compared with ex vivo biodistribution data. Results. For all brain regions, ICC analysis showed excellent agreement between observers. Reproducibility, estimated by calculation of standard deviation of the between-observer differences, was demonstrated by an average of 17% expressed as coefficient of variation. Uptake of [11C]AF150(S) derived from ROI analysis closely matched ex vivo biodistribution data. Conclusions. The proposed method provides a reproducible and tracer-independent method for ROI analysis of rat brain PET data.
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Vituri, Dagmar Willamowius, and Yolanda Dora Martinez Évora. "Reliability of indicators of nursing care quality: testing interexaminer agreement and reliability." Revista Latino-Americana de Enfermagem 22, no. 2 (April 2014): 234–40. http://dx.doi.org/10.1590/0104-1169.3262.2407.
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OBJECTIVE: this study sought to test the interexaminer agreement and reliability of 15 indicators of nursing care quality.METHODS: this was a quantitative, methodological, experimental, and applied study conducted at a large, tertiary, public teaching hospital in the state of Paraná. For data analysis, the Kappa (k) statistic was applied to the categorical variables - indicators 1 to 11 and 15 - and the interclass correlation coefficient (ICC) to the continuous variables - indicators 12, 13, and 14, with the corresponding 95% confidence intervals. The categorical data were analyzed using the Lee software, elaborated by the Laboratory of Epidemiology and Statistics of Dante Pazzanese Institute of Cardiology - Brazil, and the continuous data were assessed using BioEstat 5.0.RESULTS: the k-statistic results indicated excellent agreement, which was statistically significant, and the values of the ICC denoted excellent and statistically significant reproducibility/agreement relative to the investigated indicators.CONCLUSION: the investigated indicators exhibited excellent reliability and reproducibility, thus showing that it is possible to formulate valid and reliable assessment instruments for the management of nursing care.
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Barry, William T., Dawn N. Kernagis, Holly K. Dressman, Ryan J. Griffis, J'Vonne D. Hunter, John A. Olson, Jeff R. Marks, et al. "Intratumor Heterogeneity and Precision of Microarray-Based Predictors of Breast Cancer Biology and Clinical Outcome." Journal of Clinical Oncology 28, no. 13 (May 1, 2010): 2198–206. http://dx.doi.org/10.1200/jco.2009.26.7245.
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Purpose Identifying sources of variation in expression microarray data and the effect of variance in gene expression measurements on complex predictive and diagnostic models is essential when translating microarray-based experimental approaches into clinical assays. The technical reproducibility of microarray platforms is well established. Here, we investigate the additional impact of intratumor heterogeneity, a largely unstudied component of variance, on the performance of several microarray-based assays in breast cancer. Patients and Methods Genome-wide expression profiling was performed on 50 core needle biopsies from 18 breast cancer patients using Affymetrix GeneChip Human Genome U133 Plus 2.0 arrays. Global profiles of expression were characterized using unsupervised clustering methods and variance components models. Array-based measures of estrogen receptor (ER) and progesterone receptor (PR) status were compared with immunohistochemistry. The precision of genomic predictors of ER pathway status, recurrence risk, and sensitivity to chemotherapeutics was evaluated by interclass correlation. Results Global patterns of gene expression demonstrated that intratumor variation was substantially less than the total variation observed across the patient population. Nevertheless, a fraction of genes exhibited significant intratumor heterogeneity in expression. A high degree of reproducibility was observed in single-gene predictors of ER (intraclass correlation coefficient [ICC] = 0.94) and PR expression (ICC = 0.90), and in a multigene predictor of ER pathway activation (ICC = 0.98) with high concordance with immunohistochemistry. Substantial agreement was also observed for multigene signatures of cancer recurrence (ICC = 0.71) and chemotherapeutic sensitivity (ICC = 0.72 and 0.64). Conclusion Intratumor heterogeneity, although present at the level of individual gene expression, does not preclude precise microarray-based predictions of tumor behavior or clinical outcome in breast cancer patients.
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Griessenauer, Christoph J., Joseph H. Miller, Bonita S. Agee, Winfield S. Fisher, Joel K. Curé, Philip R. Chapman, Paul M. Foreman, Wilson A. M. Fisher, Adam C. Witcher, and Beverly C. Walters. "Observer reliability of arteriovenous malformations grading scales using current imaging modalities." Journal of Neurosurgery 120, no. 5 (May 2014): 1179–87. http://dx.doi.org/10.3171/2014.2.jns131262.
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Object The aim of this study was to examine observer reliability of frequently used arteriovenous malformation (AVM) grading scales, including the 5-tier Spetzler-Martin scale, the 3-tier Spetzler-Ponce scale, and the Pollock-Flickinger radiosurgery-based scale, using current imaging modalities in a setting closely resembling routine clinical practice. Methods Five experienced raters, including 1 vascular neurosurgeon, 2 neuroradiologists, and 2 senior neurosurgical residents independently reviewed 15 MRI studies, 15 CT angiograms, and 15 digital subtraction angiograms obtained at the time of initial diagnosis. Assessments of 5 scans of each imaging modality were repeated for measurement of intrarater reliability. Three months after the initial assessment, raters reassessed those scans where there was disagreement. In this second assessment, raters were asked to justify their rating with comments and illustrations. Generalized kappa (κ) analysis for multiple raters, Kendall's coefficient of concordance (W), and interclass correlation coefficient (ICC) were applied to determine interrater reliability. For intrarater reliability analysis, Cohen's kappa (κ), Kendall's correlation coefficient (tau-b), and ICC were used to assess repeat measurement agreement for each rater. Results Interrater reliability for the overall 5-tier Spetzler-Martin scale was fair to good (ICC = 0.69) to extremely strong (Kendall's W = 0.73) on initial assessment and improved on reassessment. Assessment of CT angiograms resulted in the highest agreement, followed by MRI and digital subtraction angiography. Agreement for the overall 3-tier Spetzler-Ponce grade was fair to good (ICC = 0.68) to strong (Kendall's W = 0.70) on initial assessment, improved on reassessment, and was comparable to agreement for the 5-tier Spetzler-Martin scale. Agreement for the overall Pollock-Flickinger radiosurgery-based grade was excellent (ICC = 0.89) to extremely strong (Kendall's W = 0.81). Intrarater reliability for the overall 5-tier Spetzler-Martin grade was excellent (ICC > 0.75) in 3 of the 5 raters and fair to good (ICC > 0.40) in the other 2 raters. Conclusion The 5-tier Spetzler-Martin scale, the 3-tier Spetzler-Ponce scale, and the Pollock-Flickinger radiosurgery-based scale all showed a high level of agreement. The improved reliability on reassessment was explained by a training effect from the initial assessment and the requirement to defend the rating, which outlines a potential downside for grades determined as part of routine clinical practice to be used for scientific purposes.
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Triwibowo, Febri Dhany, Ani Rusilowati, and Dwi Anggani Linggar Bharati. "Content Validity and Reliability of The Inter-Rater Instrument for Android-Based Speaking Performance Assessment." Journal of Educational Research and Evaluation 9, no. 1 (January 8, 2021): 52–57. http://dx.doi.org/10.15294/jere.v9i1.43865.
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This research is part of development research based on problems encountered in the field, which is the absence of an android-based speaking assessment instrument and one that supports one of the conservation values of Semarang State University, which is paperless. The aim of this study was to show the results of the validity and reliability test of the developed android-based speaking performance assessment instrument. The research method used is quantitative description of 3 expert judgments. The validation instrument developed in the form of an expert assessment sheet with 4 criteria, there are ease of use, visuals, content, and benefits. Analysis of the content validity of the assessment sheet using the V coefficient by Aiken and the reliability of the instrument content using the Interclass Correlation Coefficient (ICC) analysis with the help of SPSS version 16.0. The results showed valid results with all criteria valued> 0.3, namely with the lowest index 0.8 and the highest 1.0. Inter-rater reliability test using ICC obtained a value of 0.875, which means that all the criteria for the developed android-based speaking performance assessment instrument have a good level of consistency. Based on the results, it can be showed that the android-based speaking performance assessment instrument can be used.
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Uszynski, Marcin, Helen Purtill, and Susan Coote. "Interrater Reliability of Four Sensory Measures in People with Multiple Sclerosis." International Journal of MS Care 18, no. 2 (March 1, 2016): 86–95. http://dx.doi.org/10.7224/1537-2073.2014-088.
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Background: Sensory disturbances are a major problem for people with multiple sclerosis (MS), and up to 80% of people with MS present with various sensory deficits. To date, only one study has investigated the reliability of sensory measures in people with MS. We sought to determine the interrater reliability of the verbal analogue scale (VAS), the Erasmus MC modifications to the revised Nottingham Sensory Assessment (EmNSA), Semmes-Weinstein monofilaments (SWMs), and the neurothesiometer (NT) in people with MS. Methods: A random sample of 34 people with MS who could walk independently with or without a device was tested by two raters on the same day. For categorical data, percentage agreement, Cohen's kappa, and prevalence-adjusted bias-adjusted kappa were used. For continuous data, interclass correlation coefficient (ICC[2,1]) with 95% confidence intervals (95% CIs), Bland and Altman analysis, and standard error of measurement (SEM) were calculated. Results: For NT, ICC(2,1) values were good, with the highest for first metatarsophalangeal joint (ICC[2,1] = 0.84, 95% CI = 0.69–0.92, SEM = 4.98). The highest ICC(2,1) for VAS was for the question relating to feeling numbness in the hand (ICC[2,1] = 0.93, 95% CI = 0.86–0.96, SEM = 0.64). Findings for EmNSA and SWMs need further verification owing to possible ceiling effects. Conclusions: The NT and VAS had good interrater reliability and should be considered for measuring sensation in ambulatory people with MS. Findings for EmNSA and SWMs revealed either questionable or poor reliability, suggesting the need for further investigation.
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Jin, Cao, Yan Huang, Mansoor Nasim, Yihe Yang, and Lili Lee. "Gastrointestinal Stromal Tumors Risk Stratification Utilizing Phospho-Histone H3 Evaluated by Manual Counting and Computer-Assisted Image Analysis." International Journal of Surgical Pathology 27, no. 7 (May 30, 2019): 706–12. http://dx.doi.org/10.1177/1066896919851866.
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Background. Risk of progressive disease of gastrointestinal stromal tumors (GISTs) relies on mitotic index, size, and location of the tumor. However, manual mitotic counting on hematoxylin and eosin–stained slides (MMC-HE) is inefficient with low reproducibility. Manual count of phospho-histone H3 (MC-PHH3)-positive cells on immunohistochemical stained slides has been shown to have comparable reliability with MMC-HE. This study aims to confirm the reliability of MC-PHH3 in GISTs compared with MMC-HE and then to further compare MC-PHH3 with computer-assisted image analysis of PHH3-positive cells (Comp-PHH3). Methods. The study included 119 patients with GISTs. PHH3 stains were performed. MC-PHH3 was assessed as counts/5 mm2 high-power fields. Whole slide images were captured and the tumor area with greatest mitotic activity was manually identified. The PHH3-positive cells were automatically counted in 0.5 mm2 using Ventana Virtuoso software. Results. MMC-HE ranged from 0 to 157/5 mm2. MC-PHH3 ranged from 0 to 35.6/5 mm2. Comp-PHH3 ranged from 0 to 66/0.5 mm2. Interclass correlation coefficient (ICC) indicates good agreement between the 3 pathologists for MC-PHH3 (ICC = 0.74, P = .42). There is a strong correlation between MMC-HE and MC-PHH3. The Spearman correlation coefficient was 0.63 ( P < .0001). Lin’s concordance further indicated a moderate diagnostic agreement between MC-PHH3 and Comp-PHH3. Conclusion. MC-PHH3 is proposed as a superior alternative to MMC-HE with potential application in GIST reporting and prognostication. Furthermore, Comp-PHH3 may be a valid alternative to MC-PHH3.
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Zadrożny, Łukasz, Piotr Regulski, Katarzyna Brus-Sawczuk, Marta Czajkowska, Laszlo Parkanyi, Scott Ganz, and Eitan Mijiritsky. "Artificial Intelligence Application in Assessment of Panoramic Radiographs." Diagnostics 12, no. 1 (January 17, 2022): 224. http://dx.doi.org/10.3390/diagnostics12010224.
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The aim of this study was to assess the reliability of the artificial intelligence (AI) automatic evaluation of panoramic radiographs (PRs). Thirty PRs, covering at least six teeth with the possibility of assessing the marginal and apical periodontium, were uploaded to the Diagnocat (LLC Diagnocat, Moscow, Russia) account, and the radiologic report of each was generated as the basis of automatic evaluation. The same PRs were manually evaluated by three independent evaluators with 12, 15, and 28 years of experience in dentistry, respectively. The data were collected in such a way as to allow statistical analysis with SPSS Statistics software (IBM, Armonk, NY, USA). A total of 90 reports were created for 30 PRs. The AI protocol showed very high specificity (above 0.9) in all assessments compared to ground truth except from periodontal bone loss. Statistical analysis showed a high interclass correlation coefficient (ICC > 0.75) for all interevaluator assessments, proving the good credibility of the ground truth and the reproducibility of the reports. Unacceptable reliability was obtained for caries assessment (ICC = 0.681) and periapical lesions assessment (ICC = 0.619). The tested AI system can be helpful as an initial evaluation of screening PRs, giving appropriate credibility reports and suggesting additional diagnostic methods for more accurate evaluation if needed.
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Jago, Emily, Alain P. Gauthier, Ann Pegoraro, and Sandra C. Dorman. "An Assessment of the Validity of an Audio-Video Method of Food Journaling for Dietary Quantity and Quality." Journal of Nutrition and Metabolism 2019 (March 26, 2019): 1–8. http://dx.doi.org/10.1155/2019/9839320.
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Objective. To validate an audio-video (AV) method of food journaling, in a free-living scenario, compared to direct, weighed food assessment. Design and Setting. Data were collected in a cafeteria. Meals, selected by participants (n=30), were documented using the AV method: participants video-recorded their tray while audio-recording a description of their selected meal, after which the research team digitally weighed each food item and created an itemized diary record of the food. Variables Measured. Data from the AV method and from the weighed food diaries were transcribed and entered into a nutrition software analysis program (Nutribase Pro 10.0). Nutrient outputs were compared between the two methods including kilocalories, macronutrients, and selected micronutrients. Analyses. Using mean scores for each variable, Wilcoxon signed-rank test and Spearman’s correlation coefficients were conducted. Interclass correlation coefficient (ICC) was calculated for absolute agreement between the two methods to assess interrater reliability. Results. With the exception of Vitamin E and total weight, nutrient values were highly correlated between methods and were statistically significant given alpha = 0.05, power = 0.95, and effect size of 0.70. Conclusions. The AV method may be a meaningful alternative to diary recording in a free-living setting.
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Aristizabal, Juan C., Alejandro Estrada Restrepo, and Argenis Giraldo García. "Development and validation of anthropometric equations to estimate body composition in adult women." Colombia Médica 49, no. 2 (January 1, 2018): 154–59. http://dx.doi.org/10.25100/cm.v49i2.3643.
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Objective: To develop anthropometric equations to predict body fat percentage (BF%) in adult women. Methods: In 151 women (aged 18-59) BF% was obtained by hydrodensitometry with simultaneous measurement of lung volumes. Body weight, height, eight- skinfold thickness (STs) and six- circumference (CIs) measurements were obtained from all participants. Subjects data were randomly divided in two groups, equation-building group (n=106) and validation group (n=45). The equation-building group was used to run multiple linear regression models using anthropometric measurements as predictors to find the best prediction equations of the BF%. The validation group was used to compare the performance of the new equations with those of Durnin-Womersley, Jackson-Pollock and Ramirez-Torun. Results: There were two preferred equations: Equation 1 = 11.76 + (0.324 x tricipital ST) + (0.133 x calf ST) + (0.347 x abdomen CI) + (0.068 x age) - (0.135 x height) and Equation 2 = 11.37 + (0.404 x tricipital ST) + (0.153 x axilar ST) + (0.264 x abdomen CI) + (0.069 x age) - (0.099 x height). There were no significant differences in BF% obtained by hydrodensitometry (31.5±5.3) and Equation 1 (31.0±4.0) and Equation 2 (31.2±4.0). The BF% estimated by Durning-Womersley (35.8±4.0), Jackson-Pollock (26.5±5.4) and Ramirez-Torun (32.6±4.8) differed from hydrodensitometry (p<0.05). The interclass correlation coefficient (ICC) was high between hydrodensitometry and Equation 1 (ICC=0.77), Equation 2 (ICC=0.76), and Ramirez-Torun equation (ICC=0.75). The ICC was low between hydrodensitometry and Durnin-Womersley (ICC=0.51) and Jackson-Pollock (ICC=0.53) equations. Conclusion: The new Equations-1 and 2, performed better than the commonly used anthropometric equations to predict BF% in adult women.
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Demirel, Akif, Olgu Demirci, and Zeynep Ökte. "Accuracy of In Vitro Radiographs in Determining the Remaining Dentin Thickness below Deep Dentin Caries in Deciduous Molars." Balkan Journal of Dental Medicine 24, no. 3 (November 1, 2020): 22–27. http://dx.doi.org/10.2478/bjdm-2020-0024.
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SummaryBackground/Aim: The determination of remaining dentin thickness (RDT) is quite critical in providing appropriate treatment indications especially in deciduous molars. The aim of this study was to investigate the accuracy of in vitro pre-operative radiographs before caries removal in RDT measurement.Material and Methods: This in vitro study was conducted with 30 lower deciduous second molars with deep approximal dentinal caries. Following the standardized digital radiographs were obtained, RDT was measured by determining the closest distance between the carious lesion and the pulp chamber on the computer software. After caries removal, the samples were sectioned in mesio-distal direction and photographed. RDT was measured on photographs similarly to radiographic measurements. In statistical analysis, Interclass Correlation Coefficient (ICC), Wilcoxon-Signed and Bland Altman Plot (BAP) tests were performed to determine the agreement and statistically difference.Results: The mean RDT value in photographs was found to be 10% higher than measured on radiographs. Although, correlation coefficient was within confidence interval, both RDT values showed good but not excellent agreement (correlation coefficient= 0.812). Also, BAP test did not demonstrate strong agreement. In descriptive statistics, significant difference was found between two measurements (p<0.05).Conclusions: Pre-operative radiological examination can not alone provide reliable results regarding the accurate determination depth of caries lesions. Clinicians should also consider operative diagnostic criteria for appropriate treatment options in deciduous teeth.
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Weiher, Moritz, Felix Gunnar Richtering, Yvonne Dörffel, and Hans-Peter Müller. "Simplification of 2D shear wave elastography by enlarged SWE box and multiple regions of interest in one acquisition." PLOS ONE 17, no. 9 (September 9, 2022): e0273769. http://dx.doi.org/10.1371/journal.pone.0273769.
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Two-dimensional (2D) Shear Wave Elastography (SWE) is an easy to perform technique to evaluate the liver stiffness. To simplify the procedure and reduce the acquisition time we enlarged the size of the SWE-box and set ten regions of interest (ROI) in one acquisition. We compare the accuracy of this method to ten separate acquisitions in a small box each with a single ROI measurement. Sixty-nine volunteers with diffuse chronic liver disease were studied with 2D-SWE using a Canon Aplio i800 ultrasound system. The shear-wave-speed was measured in the right lobe in ten separate acquisitions and compared to one acquisition with increased size of the SWE-box and ten different ROI measurements. A Bland-Altmann plot was drawn and the interclass correlation coefficient (ICC) was calculated to compare both methods. Finally, 2D-SWE was successfully performed thru both methods in sixty-six participants. Between both methods the ICC is 0.82. The results of this study show a good reliability between ten separate measures and one grouped measure with ten ROI if the mean is below 1.6m/s (7.7kPa). For higher degrees of fibrosis (≥F2) further investigations are needed.
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Król-Zielińska, Magdalena, Jacek Zieliński, Adam Kantanista, Robert Szeklicki, Wiesław Osiński, and Monika Ciekot-Sołtysiak. "Polish Adaptation of the Yale Physical Activity Survey: Measurement Properties." International Journal of Environmental Research and Public Health 16, no. 13 (July 6, 2019): 2401. http://dx.doi.org/10.3390/ijerph16132401.
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The aim of this study was to assess the measurement properties of a Polish adaptation of the Yale Physical Activity Survey (YPAS-PL). The Polish cultural adaptation of the YPAS was administered to a group of 104 people aged 65 to 89 years (mean age 72 ± 5). To assess the reliability of the YPAS-PL, a test-retest procedure was applied. Validity was assessed by comparing the results of the YPAS-PL with accelerometery (ActiGraph wGT3X+). The indicators based on the YPAS-PL activities checklist were characterized by high repeatability and had better reliability values than the YPAS-PL activity dimension indices (energy expenditure interclass correlation coefficient (ICC) = 0.81, total time physical activity ICC = 0.86). We noted a significant positive relationship between energy expenditure measured by an accelerometer and the YPAS-PL (r = 0.23). We can conclude that the YPAS-PL is an adequate tool for assessing energy expenditure related to physical activity in a Polish population of older adults. We also recommend the cautious and well thought-out use of the YPAS-PL activity dimension indices (summary, vigorous, leisurely walking, moving, standing, and sitting indexes).
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Sánchez-González, María Carmen, Raquel García-Oliver, José-María Sánchez-González, María-José Bautista-Llamas, José-Jesús Jiménez-Rejano, and Concepción De-Hita-Cantalejo. "Minimum Detectable Change of Visual Acuity Measurements Using ETDRS Charts (Early Treatment Diabetic Retinopathy Study)." International Journal of Environmental Research and Public Health 18, no. 15 (July 25, 2021): 7876. http://dx.doi.org/10.3390/ijerph18157876.
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In our work, we determined the value of visual acuity (VA) with ETDRS charts (Early Treatment Diabetic Retinopathy Study). The purpose of the study was to determine the measurement reliabilities, calculating the correlation coefficient interclass (ICC), the value of the error associated with the measure (SEM), and the minimal detectable change (MDC). Forty healthy subjects took part. The mean age was 23.5 ± 3.1 (19 to 26) years. Visual acuities were measured with ETDRS charts (96% ETDRS chart nº 2140) and (10% SLOAN Contrast Eye Test chart nº 2153). The measurements were made (at 4 m) under four conditions: Firstly, photopic conditions with high contrast (HC) and low contrast (LC) and after 15 min of visual rest, mesopic conditions with high and low contrast. Under photopic conditions and high contrast, the ICC = 0.866 and decreased to 0.580 when the luminosity and contrast decreased. The % MDC in the four conditions was always less than 10%. It was minor under photopic conditions and HC (5.83) and maximum in mesopic conditions and LC (9.70). Our results conclude a high reliability of the ETDRS test, which is higher in photopic and high contrast conditions and lower when the luminosity and contrast decreases.
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Limpaiboon, Chatwadee, Nisachon Chatangam, Pattarin Burapasomboon, and Kewalee Sasiwimonphan. "INTER-OBSERVER AGREEMENT OF PI-RADS SCORE VERSION 2 FOR PROSTATE CANCER." Journal of Southeast Asian Medical Research 1, no. 2 (December 26, 2017): 63–69. http://dx.doi.org/10.55374/jseamed.v1i2.28.
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Objective:To assess the inter-observer agreement with the use of the Prostate Imaging Reporting and Data System (PI-RADS) version 2.0 for detection of prostate cancer at multiparametric magnetic resonance (MR) imaging in a tissue diagnosis patient population. Material and Method:This retrospective study was approved by the local ethics committee. Fifty-six lesions in 37 patients with elevated prostate-specific antigen levels who underwent trans-rectal ultrasound (TRUS)-guided biopsy or prostatectomy with multiparametric MR imaging of the prostate suspicious lesions detected at multiparametric MR imaging were scored by four readers of varying experience who were blinded to pathologic results by using to the newly revised PI-RADS and the scoring system version 2. Inter-observer agreement was evaluated by using the Intra-Interclass Correlation Coefficient (ICC). Results: Inter-observer agreement of four observers using the PI-RADS v2 for prostate cancer was an intermediate to good agreement beyond chance; ICC = 0.736, (95% CI: 0.565, 0.851). All observers, there was a most correlated PI-RADS assessment between observer 1 and observer 2 r = 0.758 (p<0.001). Conclusion: PI-RADS score version 2 shows intermediate to good agreement in readers of varying experience.
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Kelly, Michael S., Christopher J. Mooney, Justin F. Rosati, Melanie K. Braun, and Robert Thompson Stone. "Education Research: The Narrative Evaluation Quality Instrument." Neurology 94, no. 2 (January 13, 2020): 91–95. http://dx.doi.org/10.1212/wnl.0000000000008794.
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ObjectiveDetermining the quality of narrative evaluations to assess medical student neurology clerkship performance remains a challenge. This study sought to develop a tool to comprehensively and systematically assess quality of student narrative evaluations.MethodsThe Narrative Evaluation Quality Instrument (NEQI) was created to assess several components within clerkship narrative evaluations: performance domains, specificity, and usefulness to learner. In this retrospective study, 5 investigators scored 123 narrative evaluations using the NEQI. Inter-rater reliability was estimated by calculating interclass correlation coefficients (ICC) across 615 NEQI scores.ResultsThe average overall NEQI score was 6.4 (SD 2.9), with mean component arm scores of 2.6 for performance domains (SD 0.9), 1.8 for specificity (SD 1.1), and 2.0 for usefulness (SD 1.4). Each component arm exhibited moderate reliability: performance domains ICC 0.65 (95% confidence interval [CI] 0.58–0.72), specificity ICC 0.69 (95% CI 0.61–0.77), and usefulness ICC 0.73 (95% CI 0.66–0.80). Overall NEQI score exhibited good reliability (0.81; 95% CI 0.77–0.86).ConclusionThe NEQI is a novel, reliable tool to comprehensively assess the quality of narrative evaluation of neurology clerks and will enhance the study of interventions seeking to improve clerkship evaluation.
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Molad, Roni, Sandra R. Alouche, Marika Demers, and Mindy F. Levin. "Development of a Comprehensive Outcome Measure for Motor Coordination, Step 2: Reliability and Construct Validity in Chronic Stroke Patients." Neurorehabilitation and Neural Repair 35, no. 2 (January 7, 2021): 194–203. http://dx.doi.org/10.1177/1545968320981943.
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Background A comprehensive scale assessing motor coordination of multiple body segments was developed using a 3-phase content validation process. The Comprehensive Coordination Scale (CCS) evaluates motor coordination defined as the ability to produce context-dependent movements of multiple effectors in both spatial and temporal domains. The scale assesses motor coordination in individuals with neurological injuries at 2 levels of movement description: the motor performance level describes end point movements (ie, hand, foot), and the movement quality level describes limb joints/trunk movements contributing to end point movement. Objective To determine measurement properties of the scale in people with chronic stroke. Methods Standardized approaches determined the internal consistency (factor loadings), intrarater and interrater reliability (interclass correlation coefficient), measurement error (SEM; minimal detectable change [MDC]), construct validity, and interpretability (ie, ceiling and floor effects) of the CCS. Results Data from 30 patients with chronic stroke were used for the analysis. The internal consistency of the scale was high (0.94), and the scale consisted of separate factors characterizing end point motor performance and movement quality. Intrarater (intraclass correlation coefficient [ICC] = 0.97-0.97) and interrater (ICC=0.76-0.98) reliability of the whole scale and subscales were good to excellent. The CCS had an SEM of 1.80 points (total score = 69 points) and an MDC95 of 4.98 points. The CCS total score was related to Fugl-Meyer Assessment total and motor scores and had no ceiling or floor effects. Conclusions The CCS scale has strong measurement properties and may be a useful measure of spatial and temporal coordination deficits in chronic stroke survivors.
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Lorensa, Sisi Marda, Andi Besse Tenriawaru, and Wolly Candramila. "Development of learning video on sub materials interaction in the ecosystem based on functional feeding group of macrobenthos." Biosfer 15, no. 2 (October 23, 2022): 203–13. http://dx.doi.org/10.21009/biosferjpb.23832.
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Each organism has a different role as an integral part of an ecosystem. Nevertheless, this concept tends to be random and inaccurate in building a complete understanding of ecosystem interaction pattern. This research aims to develop learning video on ecosytem interaction, specifically on functional feeding group of macrobenthos. The feasibility of video as a learning medium was seen from five aspects of simplicity, audio, integration, balance, and effectiveness. The development of learning video is divided into two stages of the preliminary and the formative evaluation stage. In the preliminary stage, a field survey was conducted in the examples of interaction forms presented in 3 commonly used Biology textbooks. The formative evaluation stage was conducted to test the effectiveness of the learning product through self-evaluation and expert review. 5 validators of 2 lecturers and 3 high school biology teachers were assign. Data analysis was done with Lawshe method. An ICC (Interclass Correlation Coefficient) reliability test was carried out to determine the reliability of the validation instrument. The results of the reliability test using the ICC yielded an ICC value of 0.758 which puts it in the excellent category. All criteria from the aspects of the learning video media validation sheet are declared valid with CVR and CVI values of 1. Therefore, this learning video can be considered valid to be tested in limited trials.
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Cleland, Mark J., Justin P. Maloney, James L. Hay, and Brian H. Rowe. "Relationship Between Battery Capacity and the Delivery of Shocks in Prehospital Defibrillators." Prehospital and Disaster Medicine 12, no. 2 (June 1997): 61–64. http://dx.doi.org/10.1017/s1049023x00037419.
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AbstractStudy Objective:Automatic external defibrillators (AED) have enabled the medical act of defibrillation to be performed in the community by a number of non-physician providers. However, these portable, battery-powered units are costly to maintain and service. This study examines the life of AED batteries and provides a battery replacement protocol.Design:Prospective diagnostic testing of 191 field batteries to determine their ability to deliver shocks at 360 joule.Setting:Ottawa General Hospital Paramedic Program.Outcomes:Using a battery analyzer, battery capacity and the number of shocks delivered were determined for each battery (at room temperature and in a controlled, refrigerated setting). In addition, the reliability of the testing method was assessed using the interclass correlation coefficient (ICC).Results:High reliability of blinded technical assessment of the batteries was achieved (ICC = 0.85). A strong correlation between the battery's capacity and the number of shocks it can deliver was obtained. For example, a battery with a measured capacity of 75% is capable of delivering more than 30 consecutive 360 joule shocks. This compares to a battery with a capacity of 20%, which is capable of delivering only 12 consecutive 360 joule shocks.Conclusion:While manufacturers' recommendations on battery replacement always have been based on an assumed technical threshold, these recommendations are not based on individual battery performance. The system for testing batteries described in this paper, should provide significant cost savings and improve quality assurance within a prehospital AED program.
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Keller, Sarah, Zhiyue J. Wang, Amir Golsari, Anne Catherine Kim, Hendrik Kooijman, Gerhard Adam, and Jin Yamamura. "Feasibility of peripheral nerve MR neurography using diffusion tensor imaging adapted to skeletal muscle disease." Acta Radiologica 59, no. 5 (August 10, 2017): 560–68. http://dx.doi.org/10.1177/0284185117726100.
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Background Diffusion tensor imaging (DTI) of peripheral nerves may provide additional information about nerve involvement in muscular disorders, but is considered difficult due to different optimal scan parameters tailored to magnetic resonance (MR) signal properties of muscle and neural tissues. Purpose To assess the feasibility of sciatic nerve DTI using two different approaches of region of interest (ROI)-localization in DTI scans with b-values 500 s/mm2, in participants with muscular disorders and in controls. Material and Methods DTI of the thigh was conducted on a 3T system in ten patients (6 men, 4 women; mean age =54 ± 15 years) with neuromuscular disorders and ten controls. T1-weighted (T1W) images were co-registered to fractional anisotropy (FA) color-encoded images. The apparent diffusion coefficient (ADC), FA, and fiber track length (FTL) were analyzed by two operators using a freehand ROI and a single-point ROI covering the sciatic nerve. Interclass correlation coefficient (ICC) and Bland–Altman analysis were used for evaluation of inter-operator and inter-technical agreement, respectively. Results Three-dimensional visualization of sciatic nerve fiber was achievable using both techniques. The ICC of DTI metrics showed excellent inter-operator agreement both in patients and controls. Bland–Altman analysis revealed good agreement of both techniques. A maximum FTL was achieved using the single-point ROI technique, but with a lower inter-operator agreement (ICC = 0.99 vs. 0.83). The ADC and maximum FTL were significantly decreased in patients compared to controls. Conclusion Both ROI localization techniques are feasible to analyze the sciatic nerve in the setting of muscular disease. A maximum FTL is reached using the single-point ROI, however, at the cost of lower inter-operator agreement.
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Faron, Gilles, Ellen Vancutsem, Anne Naessens, Ronald Buyl, Leonardo Gucciardo, and Walter Foulon. "Effect of Genital Sampling Site on the Detection and Quantification ofUreaplasmaSpecies with Quantitative Polymerase Chain Reaction during Pregnancy." Infectious Diseases in Obstetrics and Gynecology 2017 (2017): 1–5. http://dx.doi.org/10.1155/2017/6725168.
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Objective. This study aimed to compare the qualitative and quantitative reproducibility of quantitative PCR (qPCR) forUreaplasmaspecies(Ureaplasmaspp.)throughout pregnancy and according to the genital sampling site.Study Design. Between 5 and 14 weeks of gestation (T1), vaginal, fornix, and two cervical samples were taken. Sampling was repeated during the 2nd (T2) and 3rd (T3) trimester in randomly selected T1 positive and negative women. Qualitative and quantitative reproducibility were evaluated using, respectively, Cohen’s kappa (κ) and interclass correlation coefficients (ICC) and repeated measures ANOVA on the log-transformed mean number of DNA copies for each sampling site.Results. During T1, 51/127 women were positive forU. parvumand 8 forU. urealyticum(4 patients for both). Sampling was repeated for 44/55 women at T2 and/or T3; 43 (97.7%) remained positive at the three timepoints.κranged between 0.83 and 0.95 and the ICC for cervical samples was 0.86.Conclusions. Colonization byUreaplasmaspp. seems to be very constant during pregnancy and vaginal samples have the highest detection rate.
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Rodrigues, Roiza Almeida, Raquel Lisboa Oliveira, Beatriz Grinsztejn, and Marcus Tulius T. Silva. "Validity of the International HIV Dementia Scale in Brazil." Arquivos de Neuro-Psiquiatria 71, no. 6 (June 2013): 376–79. http://dx.doi.org/10.1590/0004-282x20130042.
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HIV-associated neurocognitive disorders (HAND) remain prevalent in highly active antiretroviral therapy (HAART) era. Tests to detect HAND are needed for early diagnosis and treatment. Validity of International HIV Dementia Scale (IHDS) has been determined in different countries. The aims of this study were validate IHDS in a Brazilian cohort of HIV-patients and verify if IHDS can be reliably administered by a non-clinician health professional. One hundred and eighty-seven (187) patients were submitted to a full neuropsychological assessment. IHDS was administered twice to each patient (by a non-clinician and by a neurologist). HAND was diagnosed in 98 individuals (68 on HAART). IHDS had sensitivity of 55% and specificity of 80%. IHDS had fair agreement with neuropsychological tests (k 0.355) and moderate-to-strong agreement between different evaluators (interclass correlation coefficient (ICC) 0.684). HAND is prevalent nowadays. IHDS is quick and easy to administer, but has marginal sensitivity for the detection of HIV cognitive impairment other than dementia.
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Guaragna-Filho, Guilherme, Antônio Ramos Calixto, Georgette Beatriz De Paula, Laurione Cândido De Oliveira, André Moreno Morcillo, Maricilda Palandi De Mello, Andrea Trevas Maciel-Guerra, and Gil Guerra-Junior. "Comparison between two inhibin B ELISA assays in 46,XY testicular disorders of sex development (DSD) with normal testosterone secretion." Journal of Pediatric Endocrinology and Metabolism 31, no. 2 (January 26, 2018): 191–94. http://dx.doi.org/10.1515/jpem-2017-0351.
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Abstract Background: Inhibin B is a hormone produced by the Sertoli cells that can provide important information for the investigation of disorders of sex development (DSD) with 46,XY karyotype. The aim of this study is to compare two enzyme-linked immunosorbent assay (ELISA) assays for dosage of serum inhibin B in patients with 46,XY DSD with normal testosterone secretion. Methods: Twenty-nine patients with 46,XY DSD and normal testosterone secretion (partial androgen insensitivity syndrome [PAIS] [n=8]; 5α-reductase deficiency [n=7] and idiopathic 46,XY DSD [n=14]) were included. Molecular analysis of the AR and SRD5A2 genes were performed in all patients and the NR5A1 gene analysis in the idiopathic group. Measurements of inhibin B were performed by two second-generation ELISA assays (Beckman-Coulter and AnshLabs). Assays were compared using the interclass correlation coefficient (ICC) and the Bland-Altman method. Results: ICC was 0.915 [95% confidence interval (CI): 0.828–0.959], however, a discrepancy was observed between trials, which is more evident among higher values when analyzed by the Bland-Altman method. Conclusions: It is recommended to perform the inhibin B measurement always using the same ELISA kit when several evaluations are required for a specific patient.
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Semjonova, Guna, Janis Vetra, Aleksandrs Okss, Aleksejs Katashevs, and Vinita Cauce. "RELIABILITY OF THE DAID SMART SHIRT FOR SHOULDER GIRDLE MOTION ASSESSMENT IN HIGH STRING PLAYERS." SOCIETY. INTEGRATION. EDUCATION. Proceedings of the International Scientific Conference 4 (May 21, 2019): 268. http://dx.doi.org/10.17770/sie2019vol4.3863.
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Smart garment system is efficient for upper body movement monitoring during simple tasks. There is a lack of literature on smart textile garments being reliable for shoulder girdle motion assessment in advanced motor tasks such as high string performance. The aim of the article was to examine the reliability of the DAid Smart Shirt for Shoulder Girdle Motion Assessment during advanced motor tasks such as high string performance. Methods: 14 volunteer violinists aged 18.6 (SD 2.1) with a body mass index 20.05 (SD 2.3) were recruited. The violinists performed a legato bowing task. The DAid smart shirt worked as the assessment tool: a compression garment with textile strain sensors sewn onto it. Cronbach alpha coefficient, Interclass Correlation Coefficient were calculated to assess the within-session test-retest reliability. Results: An excellent and good result test-retest reliability was assessed in 57% of the violinists, for other 43%, the ICC and Cronbach alpha coefficient was less than 0.59. Conclusion: the DAid Smart shirt is reliable for shoulder girdle motion assessment during high string performance. The smart textile garment should be customized and suitable for the body in order to assess shoulder girdle motion during high level or advanced activities such as high string performance.
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Srimurugan Pratheep, Neeraja, Pascal Madeleine, and Lars Arendt-Nielsen. "Relative and absolute test-retest reliabilities of pressure pain threshold in patients with knee osteoarthritis." Scandinavian Journal of Pain 18, no. 2 (April 25, 2018): 229–36. http://dx.doi.org/10.1515/sjpain-2018-0017.
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Abstract Background and aims: Pressure pain threshold (PPT) and PPT maps are commonly used to quantify and visualize mechanical pain sensitivity. Although PPT’s have frequently been reported from patients with knee osteoarthritis (KOA), the absolute and relative reliability of PPT assessments remain to be determined. Thus, the purpose of this study was to evaluate the test-retest relative and absolute reliability of PPT in KOA. For that purpose, intra- and interclass correlation coefficient (ICC) as well as the standard error of measurement (SEM) and the minimal detectable change (MDC) values within eight anatomical locations covering the most painful knee of KOA patients was measured. Methods: Twenty KOA patients participated in two sessions with a period of 2 weeks±3 days apart. PPT’s were assessed over eight anatomical locations covering the knee and two remote locations over tibialis anterior and brachioradialis. The patients rated their maximum pain intensity during the past 24 h and prior to the recordings on a visual analog scale (VAS), and completed The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and PainDetect surveys. The ICC, SEM and MDC between the sessions were assessed. The ICC for the individual variability was expressed with coefficient of variance (CV). Bland-Altman plots were used to assess potential bias in the dataset. Results: The ICC ranged from 0.85 to 0.96 for all the anatomical locations which is considered “almost perfect”. CV was lowest in session 1 and ranged from 44.2 to 57.6%. SEM for comparison ranged between 34 and 71 kPa and MDC ranged between 93 and 197 kPa with a mean PPT ranged from 273.5 to 367.7 kPa in session 1 and 268.1–331.3 kPa in session 2. The analysis of Bland-Altman plot showed no systematic bias. PPT maps showed that the patients had lower thresholds in session 2, but no significant difference was observed for the comparison between the sessions for PPT or VAS. No correlations were seen between PainDetect and PPT and PainDetect and WOMAC. Conclusions: Almost perfect relative and absolute reliabilities were found for the assessment of PPT’s for KOA patients. Implications: The present investigation implicates that PPT’s is reliable for assessing pain sensitivity and sensitization in KOA patients.
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Anwar, Yunita Arian Sani, Eka Junaidi, and Syarifa Wahidah Al Idrus. "Pengembangan Rubrik Keterampilan Praktik dan Sikap Ilmiah pada Praktikum Biokimia: Kajian Validitas dan Reliabilitas." Jurnal Pijar Mipa 16, no. 1 (January 20, 2021): 121. http://dx.doi.org/10.29303/jpm.v16i1.2347.
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Penelitian ini bertujuan untuk mengembangkan instrumen keterampilan praktik dan sikap ilmiah dalam kegiatan laboratorium mata pelajaran biokimia. Penilaian instrumen diawali dengan expert judgement menggunakan analisis indeks Aiken untuk validasi, dan Interclass Correlation Coefficients (ICC) untuk uji reliabilitas. Instrumen yang valid diujikan kepada 123 responden dan dianalisis menggunakan korelasi item-total korelasi dan Cronbach's alpha dengan menggunakan program software SPSS versi 21. Pada rubrik keterampilan praktis terdapat 18 indikator dan 44 pernyataan dalam angket sikap ilmiah yang dinyatakan valid oleh para ahli sebagai instrumen, dan memiliki reliabilitas sedang. Uji coba pada responden menunjukkan bahwa rubrik keterampilan praktik dan sikap ilmiah memiliki validitas dan reliabilitas yang baik untuk menilai kegiatan laboratorium pada mata kuliah biokimia. Instrumen ini diharapkan dapat memudahkan penilaian pada pembelajaran biokimia di laboratorium.
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Junger, A., J. Klasen, F. Brenck, R. Röhrig, G. Hempelmann, and B. Hartmann. "Impact of Different Sampling Strategies on Score Results of the Nine Equivalents of Nursing Manpower Use Score (NEMS)." Methods of Information in Medicine 46, no. 04 (2007): 410–15. http://dx.doi.org/10.1160/me0387.
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Summary Objective: Prospective observational study to assess the impact of two differentsampling strategies on the score results of the NEMS, used widely to estimate the amount of nursing workload in an ICU. Methods: NEMS scores of all patients admitted to the surgical ICU over a one-year period were automatically calculated twice a day with a patient data management system for each patient day on ICU using two differentsampling strategies (NEMSindividual: 24-hour intervals starting from the time of admission; NEMS8a.m.: 24-hour intervals starting at 8 a.m.). Results: NEMSindividual and NEMS8a.m. were collected on 3236 patient days; 687 patients were involved. Significantly lower scores were found for the NEMS8a.m. (25.0 ± 8.7) compared to the NEMSindividual (26.1 ± 8.9, p <0.01); the interclass correlation coefficient (ICC) was good but not excellent: 0.78. The inter-rater correlation between the two NEMS scores was high or very high (κ = 0.6-1.0) for six out of nine variables of the NEMS. Conclusions: Different sampling strategies produce different score values, especiallydueto the end of stay. This has to betaken into accountwhen using the NEMS in quality assurance projects and multi-center studies.
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Wang, Cheng, Chengyang Yu, Weiwei Guo, Zhenpo Wang, and Jiyuan Tan. "Identification of Typical Sub-Health State of Traction Battery Based on a Data-Driven Approach." Batteries 8, no. 7 (July 4, 2022): 65. http://dx.doi.org/10.3390/batteries8070065.
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As the core component of an electric vehicle, the health of the traction battery closely affects the safety performance of the electric vehicle. If the sub-health state cannot be identified and dealt with in time, it may cause traction battery failure, pose a safety hazard, and cause property damage to the driver and passengers. This study used data-driven methods to identify the two typical types of sub-health state. For the first type of sub-health state, the interclass correlation coefficient (ICC) method was used to determine whether there was an inconsistency between the voltage of a single battery and the overall voltage of the battery pack. In order to determine the threshold, the ICC value of each vehicle under different working conditions was analyzed using box plots, and a statistical ICC threshold of 0.805 was used as the standard to determine the first sub-health type. For the second type of sub-health state, the Z-score and the differential area method were combined to determine whether the single cell voltage deviated from the overall battery pack voltage. A battery whose voltage differential area exceeds the range of u ± 3σ is regarded as having a sub-health state. The results show that both methods can accurately judge the sub-health state type of a single battery. Furthermore, combined with the one-month operation data of the vehicle, we could calculate the sub-health state frequency of each single battery and take single batteries with a high frequency as the key object of attention in future vehicle operations.
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Muge Tokuc and Muge Bulut. "DIFFERENT METHODS OF AGE ESTIMATION IN CHILDREN WITH MILD TO MODERATE HYPODONTIA." International Journal of Forensic Odontology 7, no. 1 (June 20, 2022): 1–10. http://dx.doi.org/10.56501/intjforensicodontol.v7i1.70.
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Aim: The aim of this study was to determine the most reliable method to provide consistent results in age estimation in patients with mild-to-moderate hypodontia.Material and Methods: A total of 126 patients (78 girls, 48 boys) with mild-to-moderate hypodontia were separated into 2 groups according to the severity of hypodontia considering similar age and sex distribution. A control group was formed of 126 age and sex-matched patients with complete dentition. The formation stages of permanent teeth on panoramic radiographs were evaluated according to the 12-stage classification of Haavikko, and the 8-stage classification of Demirjian et al. For dental age calculation, these stages were scored according to datasets provided by Haavikko, Demirjian et al. and Willems et al.Results: Agreement between dental age and chronological age was examined using the Interclass correlation coefficient (ICC). Sex did not significantly affect the difference between the methods (p=0.435; p=0.591). Calculated dental age according to the different methods showed significantly differences according to the study groups (p (group*method) =0.003; p (group*method) =0.008). In all the groups, excellent agreement levels were obtained using the Haavikko method (ICC≥0.90).Conclusions: The Haavikko method was detected as more reliable in healthy Turkish children and children with mild-to-moderate hypodontia than the Demirjian and Willems methods.
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Pandini, Elisa Giacomina, Pierluigi Pironti, Davide Maria Maggioni, Lorenzo Impieri, Cristiana Balbino, Nicola Manta, Marco Viganò, Laura Mangiavini, and Roberto D’Anchise. "Is Caton–Deschamps Index Reliable and Reproducible in Preoperative Assessment of Patellar Height for Patellar Instability Surgery?" Applied Sciences 12, no. 10 (May 23, 2022): 5251. http://dx.doi.org/10.3390/app12105251.
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The patellar height measurement is fundamental for surgical planning in patellar instability. The Caton–Deschamps index (CDI) is a widely employed method, but a gold standard is still lacking. The aim of this study was to evaluate the reliability and reproducibility of the CDI in a patellar height assessment and to hypothesize its employment in the preoperative planning of patellar stabilization surgery. A total of 29 cases of recurrent patellar instability undergoing surgical treatment were analyzed. The preoperative and postoperative CDI were measured by six different raters (three seniors and three juniors). The interclass correlation coefficient (ICC) of the six raters was calculated to evaluate the interobserver agreement. The seniors’ and juniors’ measurements were compared to assess the CDI reproducibility. The Fleiss kappa was calculated among the six raters to estimate the agreement in favor of an anterior tibial apophysis (ATA) transposition surgery. This study shows excellent absolute agreement in terms of the ICC for the raters’ average and for single raters as units, both preoperatively (p < 0.001) and postoperatively (p < 0.001). The agreement of the surgical choice between the six observers corresponds to “substantial agreement”. This study demonstrates that the CDI is reliable and reproducible, and it could represent a valuable tool in the clinical assessment, treatment choice and pre-surgical planning of patellar instability surgery.
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Cirovic, Dragana, Ivana Petronic, Jasna Stojkovic, Ivan Soldatovic, Polina Pavicevic, Marta Bizic, Vesna Bokan-Mirkovic, Tatjana Knezevic, and Dejan Nikolic. "Cross-Cultural Adaptation and Quantitative Evaluation of Dysfunctional Voiding and Incontinence Scoring System in Pediatric Serbian Population." Medicina 55, no. 4 (April 11, 2019): 100. http://dx.doi.org/10.3390/medicina55040100.
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Background and objective: Dysfunctional voiding (DV) presents relatively frequent problem in pediatric urologist practice. The necessity for implementation of DV evaluation in the pediatric population is of particular importance, since there is no clear consensus on the clinical assessment of such condition. The aims of our study were to evaluate the test/retest reliability and reproducibility of dysfunctional voiding and incontinence scoring system: Serbian version (DVISSSR) in patients with voiding and incontinence dysfunctions without structural deformities, and to estimate cut-off value for DVISSSR. Methods: The cross-sectional study included 57 children with voiding and incontinence dysfunctions and 30 healthy pediatric controls. For the evaluation of voiding and incontinence dysfunction we used DVISS. The forward–backward method was applied for translation of the DVISS questionnaire from English into Serbian language. Reproducibility was analyzed by Interclass Correlation Coefficient (ICC). Sensitivity and specificity of DVISSSR scores was done by receiver operating curve (ROC) curve. Results: There was a significant difference in DVISSSR score between patients and controls (p < 0.001). For reliability and reproducibility of the questionnaire, there was no significant difference between repeated measurements (p = 0.141), and strong reliability (ICC = 0.957; p < 0.001). Conclusion: We have demonstrated successful translation and validation of the DVISSSR score. Moreover, a reliable scoring system of children with voiding dysfunctions should include evaluations of symptom scoring systems at the multicentric level.
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Gregório, Maria João, Ana M. Rodrigues, Clara Salvador, Sara S. Dias, Rute D. de Sousa, Jorge M. Mendes, Pedro S. Coelho, et al. "Validation of the Telephone-Administered Version of the Mediterranean Diet Adherence Screener (MEDAS) Questionnaire." Nutrients 12, no. 5 (May 22, 2020): 1511. http://dx.doi.org/10.3390/nu12051511.
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A 14-Item Mediterranean Diet Adherence Screener (MEDAS) questionnaire was developed and validated in face-to-face interviews, but not via telephone. The aims of this study were to evaluate the validity and reliability of a telephone-administered version of the MEDAS as well as to validate the Portuguese version of the MEDAS questionnaire. A convenience community-based sample of adults (n = 224) participated in a three-stage survey. First, trained researchers administered MEDAS via a telephone. Second, the Portuguese version of Food Frequency Questionnaire (FFQ), and MEDAS were administered in a semi-structured face-to-face interview. Finally, MEDAS was again administered via telephone. The telephone-administered MEDAS questionnaire was compared with the face-to-face-version using several metrics. The telephone-administered MEDAS was significantly correlated with the face-to-face-administered MEDAS [r = 0.805, p < 0.001; interclass correlation coefficient (ICC) = 0.803, p < 0.001] and showed strong agreement (k = 0.60). The MEDAS scores that were obtained in the first and second telephone interviews were significantly correlated (r = 0.661, p < 0.001; ICC = 0.639, p < 0.001). The overall agreement between the Portuguese version of MEDAS and the FFQ-derived Mediterranean diet adherence score had a Cohen’s k = 0.39. The telephone-administered version of MEDAS is a valid tool for assessing the adherence to the Mediterranean diet and acquiring data for large population-based studies.
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Rahmawati, Rahmawati, Ana Ratna Wulan, and Kusnadi Kusnadi. "Pengembangan Asesmen Kinerja Keterampilan Inquiry Laboratory pada Permasalahan Biologi Abad ke-21." Jurnal Paedagogy 9, no. 4 (October 21, 2022): 763. http://dx.doi.org/10.33394/jp.v9i4.5667.
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This study aims to develop an inquiry laboratory skill assessment on 21st Century Biological Problems. The assessment tool developed is a non-test assessment in the form of tasks and rubrics. The research and development method (R&D) was used in this study. The subjects of this research were 30 students from one of the public high schools in Banten Province. This research instrument used performance assessment tools in tasks and rubrics, while the data analysis technique used descriptive statistics and data collection purposive sampling. The study showed that the validity of Aiken's V is 0.53. It can be said that the performance assessment tool is declared valid. The reliability value had an average measure value of 0.778. Moreover, the ICC (Interclass Correlation Coefficient) value assessed by three raters was categorized as moderate or moderate reliability. Based on the results of data analysis, the resulting instrument is ready to be used directly in measuring learning outcomes or as an assessment prototype for further development, especially in measuring students' laboratory inquiry abilities.
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Zittan, E., A. H. Steinhart, H. Aran, R. Milgrom, E. Koifman, I. M. Gralnek, S. Zelber-Sagi, and M. S. Silverberg. "P146 The Toronto IBD global endoscopic reporting (TIGER) score demonstrates significant correlation with fecal calprotectin, CRP and IBD Disk in Crohn’s disease patients." Journal of Crohn's and Colitis 15, Supplement_1 (May 1, 2021): S229. http://dx.doi.org/10.1093/ecco-jcc/jjab076.273.
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Abstract Background Commonly used endoscopic indices in IBD lack ability to provide overall disease burden and severity, generate low inter-observer agreement, and demonstrate incomplete validation of some scores. We developed an endoscopic reporting tool, the Toronto IBD Global Endoscopic Reporting (TIGER) score for Crohn’s disease (CD) and ulcerative colitis (UC) patients. The aim of our study was to compare the usability and validity of the TIGER score against fecal calprotectin (FC), C-reactive protein (CRP) and IBD DISK score in CD patients. Methods A cohort of 60 CD patients participated in the study. Blinded IBD experts reviewed and graded ileocolonoscopy videos. In the validation phase, the TIGER score was compared to: (1) the Simple endoscopic Score for Crohn’s disease (SES-CD) as a reference standard and: (2) inflammatory biomarkers FC and CRP and (3) IBD Disk score. Results Inter-observer reliability per segment between reviewers was excellent: Interclass Correlation Coefficient (ICC)=0.94; [95%CI: 0.92–0.96]. For categorized TIGER score, lowest overall agreement was 96.6% [95%CI: 93.5–98.6] and lowest kappa 0.91 [95%CI: 0.84–0.98], reflecting excellent agreement. Overall agreement per segment between SES-CD and TIGER was 91% [95%CI: 84–95] with kappa coefficient 0.77 [95%CI: 0.63–0.91]. Per subject analysis for CD yielded overall agreement of 80% [95%CI: 64–91] and kappa coefficient 0.44 [95%CI: 0.14–0.75]. There was a significant correlation between TIGER and CRP (r s = .689, p < .0083), and TIGER and FC (r s = .687, p < .0001). In addition, there was significant correlation between TIGER and IBD Disk (r s = .613, p < .0001). Conclusion The TIGER score demonstrates significant correlation with FC, CRP and IBD disk score in Crohn’s disease patients and thus can be used as a reliable and simple endoscopic score for CD patients to capture overall endoscopic disease burden.
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de Baptista, Cyntia R. J. A., Amanda M. Vicente, Mariana A. Souza, Juliana Cardoso, Vanessa M. Ramalho, and Ana C. Mattiello-Sverzut. "Methods of 10-Meter Walk Test and Repercussions for Reliability Obtained in Typically Developing Children." Rehabilitation Research and Practice 2020 (August 20, 2020): 1–7. http://dx.doi.org/10.1155/2020/4209812.
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Introduction. Research and clinical settings use the 10-meter walk test (10MWT) to measure locomotor capacity with considerable methodological diversity. Comparison between healthy and disabled children is frequent; however, the reproducibility of 10MWT using different methods is unknown. Objectives. This study analysed intrasubject, test-retest reliability, and agreement of four methods of 10MWT, exploring the influence of pace, acceleration-deceleration phases, and anthropometric measurements when calculating mean velocity. Methods. This cross-sectional study evaluated 120 typical children, both sexes, aged 6, 8, 10, and 12 (n=30 for each age). The mean times and velocities of the path (10 m) and middle path (6 m) obtained at a self-selected and fast pace were analysed. Initial assessment and another after seven days recorded three measurements per method (sV6 = self-selected pace and 6 m; sV10 = self-selected pace and 10 m; fV6 = fast pace and 6 m; fV10 = fast pace and 10 m). Interclass correlation coefficient (ICC), multiple regression, and Snedecor-F test (5% significance level) were used. Results. The fV10 method had high intrasubject reliability for all tested ages (0.70<ICC>0.89); sV10 exhibited high intrasubject reliability for ages 6, 8, and 12 (0.70<ICC>0.89) and moderate for age 10 (0.50<ICC<0.69).Test-retest reliability at sV6 and fV6 did not reach high ICC in any tested ages. The test-retest reliability at sV10 and fV10 was moderate for ages 6, 8, and 12 (0.50<ICC>0.69) and poor for age 10 (0.25<ICC>0.49). There was no agreement between methods: sV6 versus sV10 (mean difference=0.91 m/s; SEM=0.036); fV6 versus fV10 (mean difference=1.70; SEM=0.046). The fV6 method versus fV10 overestimated the velocity (bias=1.70 m/s). Conclusions. For typical children, the method that ensured the highest intrasubject reliability used fast pace and 10 m. Moreover, test-retest reliability increased when adopting 10 m at both self-selected and fast pace. The methods were not equivalent but were related, and those that did not compute the entire pathway overestimated the results.
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Ilić, Velibor, Ljiljana Tasić, and Valentina Marinković. "Attitudes of the elderly towards interprofessional cooperation and collaborative pharmacy practices: Questionnaire development." Arhiv za farmaciju 71, no. 5 (2021): 410–27. http://dx.doi.org/10.5937/arhfarm71-32284.
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Population aging is progressing at the highest rate historically, leading to an increased morbidity. Therefore, higher levels of collaborative pharmaceutical practice (CPP) and interprofessional collaboration (IPC) are expected to provide the necessary improvement to the healthcare system performance. For a strong body of literature to be built in the area of CPP and IPC, methodologically sound research studies must be completed, using questionnaires with well-developed psychometric properties. Therefore, the objective was to develop a questionnaire aimed at researching the attitudes of the elderly (65+) towards IPC and CPP. A structured questionnaire was developed using the Delphi method by a team of experts (n=8) within four rounds of meetings. Reliability, question correlation and factor analysis were used for questionnaire validation. Questionnaire validation (n=40) determined the Cronbach's Alpha to be at the high value of 0.774, and reliability analysis of questionnaire's scales on the total sample (n=185) in the five Geriatric Centers confirmed a relatively high value of 0.736. Interclass correlation coefficient values were highly significant (ICC=0.749; p<0.01), which confirmed questionnaire compactness regarding CPP. An exploratory factor analysis highlighted 2 significant factors explaining 53% of the entire model variability. Both questionnaire validation (n=40) and total sample analysis (n=185) confirmed the appropriateness of the developed questionnaire.
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Adl Amini, Dominik, Manuel Moser, Erika Chiapparelli, Lisa Oezel, Jiaqi Zhu, Ichiro Okano, Jennifer Shue, et al. "A Prospective Analysis of Skin and Fingertip Advanced Glycation End-Product Devices in Healthy Volunteers." Journal of Clinical Medicine 11, no. 16 (August 12, 2022): 4709. http://dx.doi.org/10.3390/jcm11164709.
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Background: Advanced glycation end products (AGEs) have been shown to accumulate in bone and are gaining interest in connective tissue research. Aims: To investigate the intrarater reliability, two-timepoint agreement and correlations within and between two commercially available skin autofluorescence (SAF) AGE devices. Methods: Healthy volunteers were enrolled in a prospective study at a single academic institution. Each participant underwent SAF analysis by two different, commercially available devices on two occasions, 14 days apart. Upon enrollment, a general survey about the participant’s lifestyle and health status was completed and followed up on for any changes at timepoint two. Results: In total, 40 participants (F:M ratio 5:3) with an average age of 39.0 ± 12.5 years were analyzed. For the AGE reader (skin) and AGE sensor (fingertip), both intrarater reliability and two-timepoint agreement were excellent with an interclass correlation coefficient (ICC) > 0.90 and a strong correlation within both machines. However, there was no correlation between both machines for either timepoint. In total, 4 participants were identified as outliers above the +2SD. Additionally, 5 participants with dark-colored skin could not be measured with the AGE reader at timepoint one and 4 at timepoint two. In contrast, all participants were able to undergo SAF analysis with the AGE sensor, irrespective of their skin type. Conclusions: Both machines showed excellent intrarater reliability and two-timepoint agreement, but the skin AGE reader might have limited applicability in individuals with dark-colored skin. Future research on AGEs might take our findings into consideration.
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Koc, Zafer, Gurcan Erbay, and Elif Karadeli. "Internal comparison standard for abdominal diffusion-weighted imaging." Acta Radiologica 58, no. 9 (December 12, 2016): 1029–36. http://dx.doi.org/10.1177/0284185116681040.
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Background Standards for abdominal diffusion-weighted imaging (DWI), apparent diffusion coefficient (ADC) measurements, and analysis are required for reproducibility. Purpose To identify optimal internal comparison standards for DWI to normalize the measured ADC for increased accuracy of differentiating malignant and benign abdominal lesions. Material and Methods We retrospectively studied 97 lesions (89 patients; age, 57 ± 13 years) with histopathologically confirmed abdominal disease. Seven normal body parts/contents (normal parenchyma, spleen, kidney, gallbladder bile, paraspinal muscle, spinal cord, and cerebrospinal fluid [CSF]) were assessed as internal references for possible use as comparison standards. Three observers performed ADC measurements. Statistical analyses included interclass correlation coefficients (ICCs), Mann–Whitney and Kruskal–Wallis tests, and coefficient of variation (CV). ROC analyses were performed to assess diagnostic accuracy of lesion ADC and normalized ADC for differentiating lesions. Pathology results were the reference standard. Results Mean and normalized ADCs were significantly lower for malignant lesions than for benign lesions ( P < 0.001). ICC was excellent for all internal references. Gallbladder had the lowest CV. Receiver operating characteristic (ROC) analyses showed that normalized ADCs obtained using normal parenchyma were better than lesion ADCs for differentiating malignant and benign abdominal lesions (area under the curve [AUC], 0.808 and 0.756, respectively). The normalized ADCs obtained using CSF shows higher accuracy than lesion ADCs (0.80 and 0.76, respectively) for differentiating between malignant and benign abdominal lesions. Conclusion The normal parenchyma from a lesion-detected organ can be used as an internal comparison standard for DWI. CSF can be used as a generalizable in plane reference standard.
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POH, MERVYN QI WEI, MARISSA LASSERE, PAUL BIRD, and JOHN EDMONDS. "Reliability and Longitudinal Validity of Computer-assisted Methods for Measuring Joint Damage Progression in Subjects with Rheumatoid Arthritis." Journal of Rheumatology 40, no. 1 (November 1, 2012): 23–29. http://dx.doi.org/10.3899/jrheum.120549.
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Objective.To compare the metric properties of a computer-assisted erosion segmentation volume measurement with scoring using the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) in a longitudinal cohort of patients with rheumatoid arthritis (RA).Methods.Thirty-two sets of baseline and 2-year followup magnetic resonance imaging (MRI) of metacarpal phalangeal 2–5 joints of patients with RA were scored using RAMRIS and segmented using OSIRIS software. The smallest detectable difference (SDD), standardized response mean (SRM), and paired t-test were used to evaluate the sensitivity to change. Eleven of the 32 patients’ MRI were segmented by both readers to evaluate interreader agreement. The 28-joint Disease Activity Score (DAS28) and Sharp erosion scores further evaluated construct and longitudinal validity.Results.Reliability of erosion progression by computer-assisted volume measurement was superior to RAMRIS [intrareader interclass correlation coefficient (ICC) 0.97 (0.94–0.99) vs 0.52 (0.22–0.73)] and interreader ICC of volume measurement was 0.85 (0.53–0.96). Computer-assisted volume measurements identified 10 of 32 patients who progressed more than the SDD progression, whereas RAMRIS identified only 4 of 32 patients (p = 0.0013). By a paired t-test, however, all MRI measures progressed significantly over 2 years (irrespective of treatment arm) and there was little difference by SRM. Construct correlational validity of the MRI methods was 0.47–0.90 for status scores and 0.33–0.81 for progression. There was no relationship between the average DAS28 and erosion progression by any imaging method.Conclusion.Computer-assisted measurement of erosion volume has good performance metrics. It had excellent intrareader and interreader reliability and was more sensitive to change than RAMRIS in this group of patients. www.ClinicalTrials.gov, NCT00451971.