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1
Chan, Lai Sheung. "Therapeutic potential of a Wnt modulator ICG-001 on nasopharyngeal carcinoma." HKBU Institutional Repository, 2017. https://repository.hkbu.edu.hk/etd_oa/410.
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According to the cancer stem cells (CSCs) hypothesis, CSCs are responsible for the treatment failures. CSCs are a subset of cells possessing stemness properties within the heterogeneous tumor mass. Therapeutic intervention on Wnt signaling is of our great interest because an aberrant Wnt signaling is an important driver to maintain the potency of CSCs. In nasopharyngeal carcinoma (NPC), deregulated expression of the Wnt signaling components is frequently observed. ICG-001 is a selective Wnt modulator (CBP antagonist) that specifically interrupts the interaction between β-catenin and CBP, thereby encourages the interaction between β-catenin and p300 and the subsequent differentiation and reduction of the CSCs subset. For this reason, the present study aimed to evaluate the therapeutic potential of ICG-001 in NPC. Results showed that ICG-001 inhibited both the migration of the NPC cells and the formation of tumor spheres. In the first part of the mechanistic studies (Chapter 3), ICG-001 was found to restore the expression of miR-150 in NPC cells. MiR-150 was further found to directly reduce CD44 expression and inhibit NPC cell migration. In the second part of the mechanistic studies (Chapter 4), ICG-001 was found to reduce the expression of Evi1 in NPC cells. The effect was accompanied with the inhibition of both the NPC cells migration and the tumor spheres formation. Two molecular axes, namely miR-96/Evi1/miR-449a and survivin/Evi1/miR-449a, were found to be involved in the inhibition of the tumor cell migration and spheroids formation. The therapeutic potential of using this CBP antagonist (ICG-001) in NPC, namely the in vitro and in vivo efficacy of ICG-001 combined with cisplatin, was examined (Chapter 5). Concurrent treatment of ICG-001 and cisplatin exhibited a synergistic inhibition on the in vitro growth and the tumor sphere forming capacity of NPC cells as well as the growth of NPC xenografts. Taken together, results presented in this thesis suggested that ICG-001 (PRI-724 is the analog of ICG-001 currently used in clinical trials) has a therapeutic potential in NPC.
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Granda, Barrena Juan Renato. "Sistema de software para el manejo de información de entidades al ICG." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2015. http://hdl.handle.net/10757/578662.
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Mérian, Juliette. "Développement et caractérisation in vivo de nanoparticules lipidiques biocompatibles au moyen des techniques d’imagerie de fluorescence et nucléaire." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P614/document.
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La nanomédecine est un secteur d’activité en plein essor depuis le développement des liposomes, nanovecteurs permettant d’encapsuler des molécules hydrosolubles ou amphiphiles pour la délivrance de médicament. Les nouveaux agents thérapeutiques synthétisés étant de plus en plus lipophiles, le développement de nouveaux vecteurs nanoparticulaires permettant leur transport constitue aujourd’hui un enjeu majeur. Les lipidots, nanoparticules lipidiques solides biocompatibles de 50 nm de diamètre, composées d’un mélange d’huile, de cire et de lécithine stabilisées par une couronne de surfactants pegylés, permettent de transporter des composés hautement hydrophobes en leur cœur. Des agents nucléaires pour la tomographie à émission monophotonique et des agents de fluorescence ont pu y être encapsulés pour l’évaluation de la biodistribution de ces nanoparticules chez la souris saine ainsi que dans différents modèles tumoraux. Un peptide de ciblage, le cRGD a également été greffé à la surface des lipidots afin d’adresser préférentiellement, dans les 3 premières heures après injection, les nanoparticules vers les tumeurs surexprimant les intégrines αvβ3. Une biodistribution particulière des lipidots dans les organes stéroïdiens (surrénales, ovaires) a été observée avec une localisation spécifique dans les zones synthétisant les hormones stéroïdiennes (le corps jaune pour les ovaires, la zone corticale pour les surrénales). Cette affinité unique a été mise à projet pour cibler des tumeurs hormono-dépendantes, ainsi que pour encapsuler des hormones ovariennes pour le traitement hormonal substitutif ou le contrôle de la procréationNanomedicine is a fast growing field since the development of liposomes, nanovectors able to encapsulate in their core or phospholipid bilayer hydrophilic or amphiphilic molecules for drug delivery purposes. Nowadays, most of the new synthetized therapeutic compounds are hydrophobic, necessitating the development of new types of nanocargos. Lipidots, 50 nm diameter biocompatible solid lipid nanoparticles, composed of a mixture of oil, wax and lecithin stabilized by a shell of pegylated surfactants, are used to encapsulate highly hydrophobic compounds in their core for vectorization purpose. Nuclear agents for simple photon emission tomography, or near infrared fluorescent dyes, have been encapsulated in the lipidot core, to assess the biodistribution of these nanoparticles in healthy mice as well as in a large range of tumor models. A targeting peptide, the cRGD motif, was also grafted on the surface of lipidots to vectorize preferentially the nanoparticles to tumors overexpressing αvβ3 integrins. An unexpected lipidot biodistribution in steroid organs (adrenal, ovary) was observed, with a specific localization in areas of steroid hormones synthesis (corpus luteum in ovaries, cortex for adrenals). This unique lipidot affinity was used to target hormono-dependent cancer cells, as well as to encapsulate ovarian hormones, like estradiol or ethynil estradiol, for hormone substitution therapy or birth control
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Warn, Tilman F. B. [Verfasser]. "Intraoperative Messung der Gewebsperfusion von Nierentransplantaten mittels ICG-Angiografie / Tilman F. B. Warn." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2016. http://d-nb.info/1099333814/34.
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Chiang, Yiu Chun. "ICG-001 inhibits metastasis of nasopharyngeal carcinoma via miRNA-134/β1-integrin axis." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/879.
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Background: ICG-001, an antagonist of CBP (CREB-binding protein), has been demonstrated to exert anti-tumor activity via the modulation of the Wnt signalling pathway. It has previously been demonstrated that miRNAs play an important role in ICG-001-mediated tumor suppression. In the present study, the role of miRNA-134 and 1-integrin in ICG-001-mediated anti-tumor activity in nasopharyngeal carcinoma (NPC) was examined. Methods: NPC cell lines including C666-1, HONE-1 and HK-1 were used in this study. RT-PCR and Western blot were used to study the expression of miRNA-134 and the protein expression of the target proteins, respectively. Confocal microscopy was used to analyse the subcellular localization of 1-integrin. In the functional studies, in vitro endothelial adhesion assay and in vivo nude mice model were used to evaluate the adhesion and migration of ICG-001-treated NPC cells in animals, respectively. Results: ICG-001 was found to up-regulate the expression of miRNA-134 and down-regulate 1-integrin in NPC cells. The effect was accompanied with the inhibition of the adhesion of NPC cells to lung endothelial cells. In addition, over-expression of miRNA-134 would down-regulate the expression of 1-integrin. Results from 1-integrin 3'UTR Renilla luciferase reporter assay confirmed that 1-integrin is a target of miRNA-134 in NPC cells. In the animal study, the ability of ICG-001-pretreated NPC cells or stable miRNA-134 expressing NPC cells to migrate to the mouse lung was greatly reduced. Conclusion: The CBP antagonist ICG-001 may further be developed as an anti-tumor agent for the treatment of nasopharyngeal carcinoma
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Pons, i. Playà Gemma. "Planificación pre-operatoria de anastomosis linfático-venosas mediante ICG-linfografía y linfo-resonancia magnética." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/383993.
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El linfedema es una enfermedad crónica progresiva originada por una anomalía funcional del sistema linfático, que puede llegar a ser muy invalidante. El cáncer de mama es la primera causa de linfedema en países desarrollados. A pesar de su notable incidencia (más de 2.000 nuevos casos por año secundarios a cáncer de mama en España), no ha recibido la atención necesaria durante mucho tiempo. Y esto se debe principalmente a la dificultad para visualizar las finas estructuras del sistema linfático y a la complejidad para entender su fisiopatología. Durante las últimas décadas ha resurgido un interés por el sistema linfático y sus patologías asociadas, con el objetivo de conseguir un tratamiento definitivo para el linfedema. La evolución de las técnicas de diagnóstico por imagen y el desarrollo de las técnicas de supermicrocirugía han permitido avanzar en el campo de la linfología. Las anastomosis linfático-venosas son un tratamiento quirúrgico para el linfedema, que requiere la identificación y mapeo de los canales linfáticos funcionantes. Actualmente ICG-Linfografía se ha posicionado como la técnica de elección para evaluar la funcionalidad del sistema linfático, y para seleccionar los candidatos para cirugía reconstructiva del sistema linfático. La Linfo-Resonancia Magnética ofrece imágenes 3D tanto del sistema linfático superficial como profundo de una extremidad completa. Estas dos exploraciones permiten obtener imágenes del sistema linfático con suficiente resolución temporal y espacial para describir los vasos linfáticos funcionantes. Esto será esencial para la planificación pre-operatoria de la microcirugía de anastomosis linfático-venosas. Presentamos nuestro protocolo para abordar el tratamiento quirúrgico del linfedema. La aplicación de este protocolo representará un avance para unificar criterios en la selección de pacientes y para conseguir una cirugía más segura, eficaz y racional.Lymphedema is a chronic progressive disease caused by abnormal lymphatic drainage. The main cause in developed countries is related to malignancy, especially breast cancer, and its treatment. Despite its significant incidence (more than 2.000 new cases per year due to breast cancer in Spain), this disorder did not receive the attention it deserved for a long time, mainly due to the complexity in understanding the physiology of the lymphatic system and the difficulty in visualizing its anatomy. In recent decades, however, interest in lymphedema has been revived with the intent to pursue a definitive surgical treatment. Recent advances in diagnostic imaging techniques and the development of supermicrosugery have led to significant progress in the field of lymphology. Lymphatico-venular anastomosis is a surgical treatment for lymphedema that requires the identification and mapping of functional lymphatic channels. Currently, ICG-lymphography is the primary imaging modality to evaluate lymphedema functionality and to select the candidates for reconstructive surgical techniques. 3T MR lymphangiography offers 3D visualization of both the superficial and deep lymphatic system of an entire limb. These non-invasive tests provides images of the lymphatic system with sufficient temporal and spatial resolution to depict functional lymphatic vessels. Such knowledge is essential for preoperative planning of LVA microsurgery. We present our protocol to approach surgical treatment for lymphedema. The application of this protocol represents a step forward in unifying the criteria to select patients and to achieve a safe, effective and rational surgery.
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Keršulytė, Gintarė. "Širdies signalų analizės metodų paieška ir kūrimas." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2007. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2007~D_20070816_142805-77618.
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Didelė dalis širdies susirgimų diagnostinių kriterijų gaunama registruojant ir analizuojant kardiosignalus, kurie atspindi tiek elektrinės širdies veiklos sutrikimus (EKG), tiek ir hemodinaminės bei mechaninės veiklos pokyčius, t.y. impedanskardiograma (IKG) ir seismokardiograma (SKG). Dar daugiau, efektyvus širdies susirgimų diagnostikos problemų sprendimas yra naujų kardiosignalų analizės technologijų kūrimas. Jau kelis dešimtmečius Furjė transformacija taikoma EKG dažnumų analizei, tuo tarpu kai IKG ir SKG dažnio charakteristikų vertinimui šis metodas nebuvo naudojamas. Darbo tikslas buvo pritaikyti Furjė analizę įvertinant bei palyginant tris sinchroniškai užregistruotus kardiosignalus, nes jie atspindi elektrinės širdies, hemodinaminės bei mechaninės širdies veiklos pokyčius geriau nei vienas EKG signalas. Kitas darbo tikslas buvo pritaikyti Furjė analizę įvertinant bei palyginant trijų sinchroniškai užregistruotų signalų - EKG, IKG ir SKG dažnio charakteristikas ir koherenciją bei klasifikuoti dvi grupes - "sveikas" ir "ligonis". Rezultatai rodo, kad koherencijos vertinimas ir spektrinė analizė gali būti naudinga gali būti naudingas širdies kraujagyslių bei plaučių sistemų ligų diagnostikai.A big part of heart disease diagnostics criteria is collected by registration and analysis of cardio signals that reflect the disturbances of the electric heart activity – electrocardiogram (EСG), changes of hemodynamic - impedance cardiograms (IСG) and mechanic activity - seismocardiogram (SСG). ECG analysis is generally applying in clinic practice, but usually in visual way only. Due to the development of the technologies, the bigger amount of data could be stored and more exact analysis of information could be carried out. Therefore, a solution of problem of effective diagnostics of heart diseases is the creation of new technologies for analysis of cardio signals. Previously Fourier series were applied to frequency analysis of ECG, but this method was not applied for estimation of ICG and SCG frequency characteristics. In this thesis the frequency analysis method was applied to three cardio signals, because they reflect the electrical and mechanical work of the human heart better as entirely ECG signal. The main aim of this work was to adapt Fourier transformation to assessing and comparing some characteristics of hereinbefore signals, such as coherence and classify two searching groups - “healthy” and “sick”. Results showed that rating of coherence and spectral analysis could be useful for rightly analyzing and classifying the searching groups.
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Mork, Christian. "ICG-Clearance und hepatovenöse Sauerstoffsättigung als erweitertes Monitoring der postoperativen Leberfunktion eine prospektive, klinische Beobachtungsstudie /." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972767266.
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Kland, Konstanze. "Evaluation der ICG-Clearance (LIMON®) zur Diagnostik von Leberfunktionsstörungen bei Patienten nach allogener Stammzelltransplantation." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-130870.
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Alexandersson, Pelle. "Psykometrisk prövning av PG-13; ett självskattningsinstrument för ihållande sorg." Thesis, Stockholms universitet, Psykologiska institutionen, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-43566.
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Frågan om ”normal” respektive ”patologisk” sorg har under en lång tid varit ett omdiskuterat ämne inom psykologin och psykiatrin. En grupp forskare har tagit fram kriterier på ett syndrom som fått benämningen ihållande sorg (”prolonged grief”). Studier har visat på att ihållande sorg är ett distinkt syndrom separat från depression, posttraumatisk stressyndrom och generaliserat ångestsyndrom. Ihållande sorg föreslås ingå som en diagnos i de kommande versionerna av de diagnostiska manualerna DSM och ICD. Syftet med denna studie var att översätta självskattningsinstrumentet Prolonged Grief Disorder (PG-13) till svenska, och undersöka dess reliabilitet och validitet genom bland annat en explorativ och konfirmatorisk faktoranalys. Studien genomfördes på ett annonsrekryterat heterogent sample (n=162 varav 90 % var kvinnor) vad gäller typ av dödsfall och relation till den avlidne. Respondenterna besvarade en webb- eller pappersenkät som bestod av 75 items. PG-13 bedöms ha en hög reliabilitet, god begrepps- och samtidig validitet samt en måttlig diskriminativ validitet.
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Matušek, Adam. "Modelling of cardiac impedance signals." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2012. http://www.nusl.cz/ntk/nusl-219669.
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Tato diplomová práce se zabývá vytvořením modelu signálu impedančního měření srdce (ICG signál). Impedanční kardiografie podává informaci o změně srdečního objemu během srdečního cyklu. Modelování signálu předchází statistická analýza vzájemné pozice ICG signálu vzhledem k dalším mechanickým srdečním signálům. Konstrukce modelu vychází z reálných nasnímaných signálů. Konečný ICG model je začleněn do již existujícího modelu mechanických interakcí mezi srdcem a plícemi. Výsledkem je funkční model kardio-respiračních interakcí, který bude sloužit v dalších částech výzkumu laboratoře PRETA.
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Wiemann, Oliver [Verfasser]. "ICG-gestützte fluoreszenzoptische Bildgebung (Xiralite) bei Psoriasis-Arthritis : Klassifikation extraartikulärer Befunde und klinische Bedeutung / Oliver Wiemann." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1223927652/34.
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La, Joie Elaine Naomi. "Tissue welding : studies of pulsed diode laser interaction with ICG stained porcine aorta and elastin-based biomaterial /." Full text open access at:, 1995. http://content.ohsu.edu/u?/etd,249.
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Stingaciu, Laura-Roxana [Verfasser]. "Characterization of natural porous media by NMR and MRI techniques: high and low magnetic field studies for estimation of hydraulic properties / Laura-Roxana Stingaciu. Forschungszentrum Jülich GmbH, Institute of Chemistry and Dynamics of th Geosphrer (ICG, Agrosphere (ICG-4)." Jülich : Forschungszentrum, Zentralbibliothek, 2010. http://d-nb.info/1010334549/34.
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Nocilli, Matteo. "Studio e valutazione preliminare del ruolo dell'imaging a fluorescenza per il trattamento chirurgico dell'endometriosi." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/19376/.
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In questa tesi si tratterà l’uso endovenoso del verde indocianina per consentire la visualizzazione in tempo reale della perfusione intestinale nelle donne con endometriosi retto-sigmoidea che possono essere candidate alla resezione segmentaria. Al fine di valutare la sicurezza dell’intervento in termini di bontà di vascolarizzazione del sito oggetto della resezione, la principale misurazione di nostro interesse è stata la valutazione della perfusione ematica intestinale della neo-anastomosi.
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Velasco, Santoscoy María Martha de la Paz. "Hardware Control of a Near Infrared Fluorescence System : LabVIEW Programming and Evaluation." Thesis, Linköpings universitet, Biomedicinsk instrumentteknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-129604.
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Indocyanine green (ICG) is a fluorescent dye used as an indicator in medicine and surgery. The maximum absorption wavelength of ICG is at 785 nm, while the maximum emission is around 820 nm. ICG is nontoxic and is rapidly excreted into the bile. Near infrared (NIR) fluorescence imaging or spectroscopy offer new settings for seeing the blood vessels, and also in oncological applications for finding sentinel lymph nodes (SLN) to investigate if the cancer has spread from the tumor to the lymphatic system. Given the aforementioned applications, the aim of this thesis was to develop a hardware control and a user interface in LabVIEW, and to evaluate the software, as well as the instrumentation using phantom measurements.The system consisted of a spectrometer, a laser (785 ± 5 nm) for ICG excitation, optical filters, and a fiber optical probe containing five fibers for light excitation, and one for light collection. The basic LabVIEW program designed for the spectrometer was used, and additional features were added such as the recording functions, online measurements, opening of the recorded files, saving comments, and a loop was created for the laser control. Optical phantoms were prepared to model tissue for measurements using 20 % intralipid that gave μs = 298 mm−¹ at the excitation wavelength. Agar 1% w/v and ICG were added to the phantoms using different fluorophore concentrations of 2 μg/mL, 10 μg/mL, 20 μg/mL, 25 μg/mL, and 40 μg/mL. The objective was to perform controlled measurements of steady state ICG fluorescence, the dynamics of photobleaching at different concentrations, and to find the optimal ICG concentration for obtaining the maximum fluorescence intensity. The light to excite ICG fluorescence emission was provided by using a laser output power of 10.4 mW and 200 ms of integration time in the spectrometer for optimal measurements.Measurements using the different gel phantoms showed maximum fluorescence ICG concentration to be between 16 μg/mL and 20 μg/mL. Moreover, photobleaching measurements showed to be ICG concentration-dependent, where those concentrations higher than the optimal one incrementally photobleached with time after being exposed to light. Higher concentrations presented an incremental photobleaching where they first reached a maximum peak and then the intensity decayed with time. Additionally, laser reflection at 782 nm showed that the reflection increased with time ranging from 130% – 460% as the ICG photobleached to 50% of its initial value. Normalization of ICG by the laser reflection signal was investigated to compensate for the intensity variations due to the measurement parameters including the distance from the light source to the target, and the angle of inclination of the probe. The lowest ICG concentration detectable by the system was 0.05 μg/mL.In conclusion, a LabVIEW hardware control and user interface was developed for controlling the spectrometer and the laser. Several measurements were made using the different phantoms, where the optimal concentration of ICG was estimated. It was shown that ICG fluorescence intensity and photobleaching behavior were dependent on the concentration. The results gave suggestions for future experimental design.NIRF
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Kland, Konstanze [Verfasser], and Jan [Akademischer Betreuer] Braess. "Evaluation der ICG-Clearance (LIMON) zur Diagnostik von Leberfunktionsstörungen bei Patienten nach allogener Stammzelltransplantation / Konstanze Kland. Betreuer: Jan Braess." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1015064639/34.
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Krug, Christian [Verfasser], and Andrea [Akademischer Betreuer] Baur-Melnyk. "Evaluation der möglichen klinischen Anwendbarkeit eines mittels ICG kontrastverstärkten, kombinierten optischen Bildgebungs-/Röntgensystems / Christian Krug ; Betreuer: Andrea Baur-Melnyk." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1153338548/34.
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Wada, Toshiaki. "Enhanced anastomotic healing by Daikenchuto(TJ-100) in rats." Kyoto University, 2019. http://hdl.handle.net/2433/236610.
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Werner, Stephanie Gabriele [Verfasser]. "Implementierung, Standardisierung und Evaluierung einer neuen ICG-gestützten fluoreszenzoptischen Bildgebungstechnologie mit dem Xiralite-Verfahren zur Entzündungsdiagnostik bei rheumatischen Krankheitsbildern / Stephanie Gabriele Werner." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1027307159/34.
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Mérian, Juliette. "Développement et caractérisation in vivo de nanoparticules lipidiques biocompatibles au moyen des techniques d'imagerie de fluorescence et nucléaire." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00747071.
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La nanomédecine est un secteur d'activité en plein essor depuis le développement des liposomes, nanovecteurs permettant d'encapsuler des molécules hydrosolubles ou amphiphiles pour la délivrance de médicament. Les nouveaux agents thérapeutiques synthétisés étant de plus en plus lipophiles, le développement de nouveaux vecteurs nanoparticulaires permettant leur transport constitue aujourd'hui un enjeu majeur. Les lipidots, nanoparticules lipidiques solides biocompatibles de 50 nm de diamètre, composées d'un mélange d'huile, de cire et de lécithine stabilisées par une couronne de surfactants pegylés, permettent de transporter des composés hautement hydrophobes en leur cœur. Des agents nucléaires pour la tomographie à émission monophotonique et des agents de fluorescence ont pu y être encapsulés pour l'évaluation de la biodistribution de ces nanoparticules chez la souris saine ainsi que dans différents modèles tumoraux. Un peptide de ciblage, le cRGD a également été greffé à la surface des lipidots afin d'adresser préférentiellement, dans les 3 premières heures après injection, les nanoparticules vers les tumeurs surexprimant les intégrines αvβ3. Une biodistribution particulière des lipidots dans les organes stéroïdiens (surrénales, ovaires) a été observée avec une localisation spécifique dans les zones synthétisant les hormones stéroïdiennes (le corps jaune pour les ovaires, la zone corticale pour les surrénales). Cette affinité unique a été mise à projet pour cibler des tumeurs hormono-dépendantes, ainsi que pour encapsuler des hormones ovariennes pour le traitement hormonal substitutif ou le contrôle de la procréation.
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Chericoni, Domizia. "Cinetica e termodinamica della trasformazione metallo-idruro in nanoparticelle Mg-Ti." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/8340/.
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L'utilizzo dell'idrogeno come vettore energetico è uno dei temi, riguardanti la sostenibilità energetica, di maggior rilievo degli ultimi anni. Tuttavia ad oggi è ancora in corso la ricerca di un sistema che ne permetta un immagazzinamento efficiente. Il MgH2 costituisce un valido candidato per la produzione di sistemi per lo stoccaggio di idrogeno allo stato solido. In questa tesi, per migliorare le proprietà cinetiche e termodinamiche di cui questo sistema, sono stati sintetizzati dei campioni nanostrutturati composti da Mg-Ti attraverso la tecnica Inert Gas Condensation. I campioni così ottenuti sono stati analizzati dal punto di vista morfologico e composizionale, mediante la microscopia elettronica a scansione, la microanalisi e la diffrazione di raggi X. Tali analisi hanno mostrato che le dimensioni delle nanoparticelle sono comprese tra i 10-30 nm e che la tecnica IGC permette una distribuzione uniforme del titanio all'interno della matrice Mg.
Le misure di caratterizzazione per l'assorbimento reversibile di idrogeno sono state effettuate attraverso il metodo volumetrico, Sievert. I campioni sono stati analizzati a varie temperature (473K-573K). Cineticamente la presenza di titanio ha provocato un aumento della velocità delle cinetiche sia per i processi di desorbimento che per quelli di assorbimento ed ha contribuito ad una diminuzione consistente delle energie di attivazione di entrambi i processi rispetto a quelle note in letteratura per il composto MgH2. Dal punto di vista termodinamico, sia le pressioni di equilibrio ottenute dalle analisi PCT a diverse temperature, che l'entalpia e l'entropia di formazione risultano essere in accordo con i valori conosciuti per il sistema MgH2.
All'interno di questo lavoro di tesi è inoltre presentata un'analisi preliminare di un campione analizzato con la tecnica Synchrotron Radiation-Powder X Ray Diffraction in situ, presso la facility MAX-lab (Svezia), all’interno dell’azione COST, MP1103 per la ricerca di sistemi per lo stoccaggio di idrogeno allo stato solido.
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Malagón, López Paloma. "Estudio de la perfusión del colgajo DIEP mediante el uso del ICG para optimización de su rendimiento y disminución de la esteatonecrosis en reconstrucción microquirúrgica tras mastectomía oncológica." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670642.
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El verd d’indocianina (ICG) és un contrast que permet la valoració de la perfusió dels teixits de manera intraoperatòria i dinàmica, aportant informació d’interès en el camp de la reconstrucció mamària.
Aquest treball es focalitza en l’estudi del seu ús en reconstrucció microquirúrgica de mastectomia amb penjoll DIEP (Deep Inferior Epigastric Perforator).
L’objectiu principal és optimitzar el rendiment d’aquesta prova a l’hora de dissenyar el penjoll, i estableix en quin moment durant la intervenció quirúrgica és més efectiu valorar la seva perfusió, i demostrar que amb el seu ús és possible reduir la taxa de esteatonecrosis postoperatòria, una de les complicacions més freqüents en aquest tipus de reconstruccions.
Per a això es van plantejar 2 estudis:
- En el primer estudi es va valorar si existien diferències en la taxa d’esteatonecrosis postoperatòria en els penjalls DIEP per mastectomia oncològica en funció de si es va emprar (grup d’estudi) o no (grup control) l’ICG durant la intervenció quirúrgica.
- En el segon estudi es va comparar la perfusió de l’penjall DIEP amb ICG en dos moments de la cirurgia, quan la vascularització depenia de l’pedicle original (zona donant) i després de la anastomosi microquirúrgica als gots receptors mamaris interns (zona receptora). A més, es van valorar els avantatges i inconvenients associats a la realització de la prova en cada moment.
Els resultats d’ambdós estudis van mostrar que amb l’angiografia amb ICG intraoperatòria és possible disminuir la esteatonecrosis postoperatòria, tant la seva incidència com el seu grau i la necessitat de tractaments quirúrgics secundaris, sent major la seva efectivitat a l’hora de dissenyar el penjoll DIEP quan es realitza en la zona donant (abans de la secció de l’pedicle en què es basa).El verde de indocianina (ICG) es un contraste que permite la valoración de la perfusión de los tejidos de manera intraoperatoria y dinámica, aportando información de interés en el campo de la reconstrucción mamaria. Este trabajo se focaliza en el estudio de su uso en reconstrucción microquirúrgica de mastectomía con colgajo DIEP (Deep Inferior Epigastric Perforator). El objetivo principal es optimizar el rendimiento de esta prueba a la hora de diseñar el colgajo, estableciendo en qué momento durante la intervención quirúrgica es más efectivo valorar su perfusión, y demostrar que con su uso es posible reducir la tasa de esteatonecrosis postoperatoria, una de las complicaciones más frecuentes en este tipo de reconstrucciones. Para ello se plantearon 2 estudios: - En el primer estudio se valoró si existían diferencias en la tasa de esteatonecrosis postoperatoria en los colgajos DIEP para mastectomía oncológica en función de si se empleó (grupo de estudio) o no (grupo control) el ICG durante la intervención quirúrgica. - En el segundo estudio se comparó la perfusión del colgajo DIEP con ICG en dos momentos de la cirugía, cuando la vascularización dependía del pedículo original (zona donante) y tras la anastomosis microquirúrgica a los vasos receptores mamarios internos (zona receptora). Además, se valoraron las ventajas e inconvenientes asociados a la realización de la prueba en cada momento. Los resultados de ambos estudios mostraron que con la angiografía con ICG intraoperatoria es posible disminuir la esteatonecrosis postoperatoria, tanto su incidencia como su grado y la necesidad de tratamientos quirúrgicos secundarios, siendo mayor su efectividad a la hora de diseñar el colgajo DIEP cuando se realiza en la zona donante (antes de la sección del pedículo en el que se basa).
Background and objectives: The Deep Inferior Epigastric Perforator (DIEP) flap is the first option for autologous microsurgical reconstruction for oncological mastectomy, with great results. However, one of its most frequent complications is fat necrosis (up to 62.5%), as a consequence of a deficient regional perfusion of the flap, which could have important clinical and psychological repercussions, deteriorating the results and increasing reconstruction costs. The indocyanine green angiography (ICGA) has been successfully used for years in the assessment of perfusion in free flaps surgeries, and the aim of this study was to demonstrate the intraoperative use of ICGA to reduce fat necrosis in DIEP flap. Besides, it has not yet been established when the ICGA should be performed during the surgery, so the second main aim of this study is to evaluate whether it is better to perform the test on the donor or recipient sites of the DIEP flap. Methods: Two studies have been conducted. In the first one, 61 patients who underwent unilateral DIEP flap procedures for breast reconstruction after oncological mastectomy were included (24 cases with intraoperative use of ICGA during surgery, 37 cases in the control group). The follow-up period was 1 year after surgery. The association between the use of ICGA and the incidence of fat necrosis in the first postoperative year, differences in fat necrosis grade (I-V), differences in fat necrosis requiring reoperation, quality of life, and patient satisfaction were analyzed. In the second study, the intraoperative perfusion of 46 DIEP flaps was assessed twice, on the donor and recipient sites. Differences between both ischemic areas of each flap were statistically analyzed. In addition, perforator location and risk factors were evaluated in order to assess whether they are associated with changes in the perfusion of the flap between both sites. Results: In the first article, the incidence of fat necrosis was reduced from 59.5% (control group) to 29% (ICG-group) (P = 0.021) (relative risk = 0.49 [95% CI, 0.25- 0.97]). The major difference was in grade II (27% vs 2.7%, P = 0.038). The number of second surgeries for fat necrosis treatment was also reduced (45.9% vs 20.8%, P = 0.046). The ICG group had higher scores on the BREAST-Q. In the second study, differences between ischemic areas on the donor and recipient sites were statistically significant (p = 0.012). In all cases in which there was a change of area between both zones, it was always less in the donor site. That means that in all cases the flap was the same or better perfused in the recipient site. The final flap design only changed in two cases (4.3%) because of the ICGA findings on the recipient site. Besides, performing the ICGA on the donor site facilitated the identification of the best perfused areas, allowed a better planning of its placement into the recipient site, and also can be useful to choose the best perforator. Bilateral DIEP flap, lateral location of the perforator and tobacco use had a statistically significant association with lower probability to increase the perfusion area between both sites Conclusions: Intraoperative ICGA is a useful technique for reconstructive microsurgery that might improve patient satisfaction and reduce the incidence of fat necrosis by half as well as reduce its grade and the number of secondary surgeries. In addition, several advantages have been found in performing the ICGA on the donor site to assess the perfusion of the DIEP flap. In addition, performing the ICGA in the donor site (before the flap pedicle section) allowed to achieve a flap design based on the best perfused areas with greater precision.
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Glimm, Anne-Marie [Verfasser]. "Analysis of distribution and severity of inflammation in patients with osteoarthritis and rheumatoid arthritis by ICG-enhanced fluorescence optical imaging and musculoskeletal ultrasound / Anne-Marie Glimm." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1139255304/34.
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Liebich, Julia [Verfasser]. "Messung der Leberfunktion nach großen abdominalchirurgischen Eingriffen mittels Maximal Liver Function Capacity Test (LiMAx-Test) in Korrelation mit dem Indocyaningrün Test (ICG-Test) und inflammationsspezifischen Zytokinen / Julia Liebich." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1212435869/34.
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Rubino, Vincenzo. "Studio della dinamica di perfusione per la valutazione della endometriosi ureterale." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/23018/.
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L’endometriosi è una patologia provocata dalla disseminazione o dalla crescita di tessuto endometriale in sedi anomale o dall’insorgenza del tessuto endometriale, per un processo di metaplasia, al di fuori della sede abituale. Le manifestazioni cliniche dell’endometriosi possono essere molto differenti. Accanto a pazienti prive di sintomi, si ritrovano pazienti con una sintomatologia dolorosa estremamente invalidante.
L’endometriosi rappresenta una delle patologie ginecologiche più controverse: infatti, nonostante il particolare interesse riservatole negli ultimi decenni dall’intera comunità scientifica e la notevole esperienza clinica acquisita in materia, resta ad oggi, un enigma da risolvere nella quasi totalità delle sue radici ed implicazioni fisiopatologiche.
Nella seguente tesi verrà analizzato l’uso endovenoso del verde indocianina per consentire la visualizzazione in tempo reale della perfusione intestinale nelle donne con endometriosi retto-sigmoidea. Tale metodica ci consentirà di valutare la buona riuscita dell’intervento, focalizzandoci soprattutto sulla perfusione ematica intestinale della neo-anastomosi, al fine di escludere la possibile complicanza più temuta nell’ambito chirurgico, ovvero la deiscenza anastomotica (AL). Vista anche la scarsità in letteratura di metodiche consolidate per la quantificazione della perfusione in un contesto chirurgico, che non richiedano una strumentazione di altissimo livello tecnologico, (quali per esempio bracci robotici), si punterà alla implementazione di un algoritmo automatizzato, che potrà fornire i parametri di interesse insieme anche ai relativi grafici. Il tutto in uno scenario di tempistica relativamente breve, che a fronte dell’utilizzo di un hardware di elevate prestazioni, possa puntare anche al real-time, e quindi trovare applicazione direttamente durante la seduta operatoria.
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Schmidt, Florian [Verfasser], Orlando [Gutachter] Guntinas-Lichius, Andreas [Gutachter] Stallmach, and Dirk [Gutachter] Beutner. "In vivo Nahinfrarot-Fluoreszenz-Endoskopie mit Indocyaningrün (ICG) zur diagnostischen Abklärung von Kopf-Hals-Tumoren : Durchführbarkeit und Erhebung erster klinischer Daten / Florian Schmidt ; Gutachter: Orlando Guntinas-Lichius, Andreas Stallmach, Dirk Beutner." Jena : Friedrich-Schiller-Universität Jena, 2020. http://d-nb.info/120727271X/34.
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Kranzmayr, Matthias [Verfasser], Wolfgang L. E. [Akademischer Betreuer] Huber, Wolfgang L. E. [Gutachter] Huber, and Roland M. [Gutachter] Schmid. "Die Indocyaningrün-Plasmaverschwinderate (ICG-PDR) zur Beurteilung der Leberfunktion - Diagnostische Aussagekraft bei der primär sklerosierenden Cholangitis (PSC) und Einfluss biometrischer Parameter / Matthias Kranzmayr ; Gutachter: Wolfgang L. E. Huber, Roland M. Schmid ; Betreuer: Wolfgang L. E. Huber." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1196791791/34.
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Shi, Qinghai, Andreas Heinig, and Olfa Kanoun. "Design and evaluation of a portable device for the measurement of bio-impedance cardiography." Universitätsbibliothek Chemnitz, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-64632.
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Electrical impedance of biological matter is known as electrical bio-impedance or simply as bio-impedance. Bio-impedance devices are of great value for monitoring the pathological and physiological status of biological tissues in clinical and home environments. The technological progress in instrumentation has significantly contributed to the progress that has been observed during the last past decades in impedance spectroscopy and electrical impedance cardiograph. Although bio-impedance is not a physiological parameter, the method enables tissue characterization and functional monitoring and can contribute to the monitoring of the health status of a person. In this paper an inexpensive portable multi frequency impedance cardiograph device based on impedance spectroscopy technique has been developed. By means of this system the basic thoracic impedance range and the heart-action-caused changes of impedance can be measured and the hemodynamic parameters of the heart function can be determined. This system has small size and low current consumption. The impedance cardiograph signals of the electrodes configuration by Sramek, Penney and Qu in this work was measured; compared and summarized. The differences of the measuring method, the schematic circuit diagram, the measurement results and area of application between impedance cardiograph and impedance spectroscopy were discussed and compared. The performance of this sensor-system was evaluated.
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Liberale, Gabriel. "Apport de l'imagerie en fluorescence au vert d'indocyanine dans le staging et le traitement du cancer colorectal." Doctoral thesis, Universite Libre de Bruxelles, 2017. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/248402.
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Résumé:IntroductionLa chirurgie reste le seul traitement à visée curative pour les patients porteurs d’un cancer colorectal (CCR) primitif ou métastatique. L’établissement précis de l’extension de la maladie, au niveau de la tumeur primitive, des ganglions loco-régionaux et des métastases à distance représente un élément essentiel pour la prise en charge thérapeutique. Les ganglions locorégionaux et la technique du ganglion sentinellePour les patients présentant un CCR non métastatique, l’analyse pathologique des ganglions (pN) conditionne la décision d’administrer ou non une chimiothérapie adjuvante. Les patients présentant un envahissement ganglionnaire (pN+) recevront un traitement adjuvant, celui-ci n’étant le plus souvent pas indiqué chez les patients sans envahissement ganglionnaire (pN0). Près de 20 à 30% des patients classés pN0 vont cependant développer des récidives tumorales. Parmi ces patients, il est probable qu’une partie ait été sous-classée au moment du diagnostic. La technique du ganglion sentinelle (GS) permet d’identifier les ganglions les plus susceptibles d’être envahis et de réaliser des analyses anatomopathologiques plus approfondies sur un nombre plus limité d’échantillon. Cette technique est recommandée dans le cancer du sein et dans le mélanome, mais son rôle reste discuté dans le CCR. Le premier volet de cette thèse concerne les résultats d’études cliniques que nous avons menées pour évaluer le rôle de la technique du GS au bleu patenté (BP) et de l’imagerie en fluorescence (IF) au vert d’indocyanine ou indocyanine green (ICG) dans le staging ganglionnaire des patients présentant un CCR. Les principaux objectifs de ces travaux étaient d’évaluer la faisabilité de ces techniques et leur apport dans le staging des patients présentant un CCR.Notre première étude sur la technique du GS au BP, représentant la plus grande cohorte monocentrique européenne, a permis de démontrer la faisabilité de la technique. En outre, cette approche a modifié le geste chirurgical dans 12% des cas (technique in vivo) et a permis de reclasser 10% des patients initialement classés pN0 en pN+ par la réalisation de coupes sériées spécifiquement réalisées sur les ganglions démontrés comme GS. Dans une seconde étude sur la technique du GS comparant l’IF-ICG à la technique au BP, nous avons montré que ces 2 techniques étaient complémentaires, permettant d’augmenter la sensibilité globale pour la détection des métastases ganglionnaires. De plus, l’IF-ICG apparaît comme plus sensible chez les patients présentant une surcharge pondérale. En termes de sensibilité, la recherche du GS par IF est supérieure à la technique BP, ces résultats restant cependant limités, notamment en raison d’un taux élevé de faux négatifs (FN) pour les tumeurs localement avancées (pT3-4). Les métastases ganglionnaires et la carcinose péritonéaleDans le CCR, les patients métastatiques, présentant une carcinose péritonéale (CP) et/ou un envahissement ganglionnaire, ont un pronostic sombre. La chirurgie d’exérèse de la CP associée à une chimiothérapie hyperthermique intrapéritonéale (CHIP) et la réalisation de curages ganglionnaires chez les patients porteurs d’une maladie oligométastatique permettent toutefois d’obtenir des survies prolongées et parfois des guérisons, avec des résultats similaires à ceux observés chez les patients opérés pour métastases hépatiques isolées. Pour la CP, l’étendue de la maladie et la radicalité de la résection sont les principaux facteurs pronostiques de survie. La sensibilité des examens d’imagerie conventionnelle et métabolique reste cependant faible pour déterminer l’extension de la maladie péritonéale. L’évaluation de l’étendue de la CP et son exérèse sont donc essentiellement fondées sur la palpation et l’exploration visuelle réalisée durant l’intervention chirurgicale, représentant un facteur limitant pour la radicalité de la chirurgie. De façon similaire, chez les patients présentant une maladie métastatique ganglionnaire limitée, la détection peropératoire est souvent difficile, nécessitant la réalisation de curages étendus de principe, afin de s’assurer de l’exérèse des ganglions pathologiques.L’utilisation de l’IF après injection iv intra-opératoire d’ICG a été rapportée comme une technique permettant la détection de tissu tumoral tant visible que non visible (infraclinique), pouvant potentiellement aider le chirurgien et guider les gestes de résection. Aucune étude n’avait particulièrement analysé le rôle de l’IF-ICG dans la détection de CP et de métastases ganglionnaires de CCR. Le second volet de cette thèse concerne l’évaluation de l’apport de l’IF après injection iv d’ICG pour la détection de la CP et des métastases ganglionnaires dans le CCR. L’objectif primaire était de vérifier si les métastases péritonéales (MP) et ganglionnaires visibles par le chirurgien étaient effectivement détectées par l’IF-ICG peropératoire. En parallèle, nous avons évalué si l’IF-ICG permettait de détecter une maladie infraclinique, non détectée par le chirurgien dans les conditions habituelles. La première étude de cette seconde partie a permis de montrer que les MP étaient visualisées comme hyperfluorescentes à l’IF-ICG pour autant qu’elles ne soient pas d’origine mucineuse. De plus, l’IF-ICG a permis de détecter des MP non visualisées en lumière visible, permettant d’adapter le geste chirurgical et d’augmenter la radicalité de la résection dans près de 38% des cas. Dans une seconde étude, nous avons rapporté que la technique d’IF utilisée in vivo et ex vivo après injection iv d’ICG permettait d’identifier des ganglions métastatiques, détectés ou non par les imageries conventionnelles et métaboliques préopératoires. Les résultats de cette étude constituant une preuve de concept ont été ensuite confirmés dans une étude rétrospective réalisée sur l’analyse ex vivo des ganglions de patients ayant reçu une injection iv d’ICG. Dans ce travail, nous avons montré que les ganglions envahis étaient plus fluorescents que les ganglions non envahis. Toutefois, cette preuve de concept doit encore être confirmée et évaluée plus largement dans une étude prospective. Ces 2 travaux montrent donc le bénéfice potentiel de l’utilisation de l’IF après injection iv d’ICG à 2 niveaux, pour guider la chirurgie en améliorant la détection peropératoire des sites métastatiques infracliniques et pour guider l’analyse histologique, en identifiant des ganglions fluorescents sur la pièce de résection, permettant une étude anatomopathologique plus ciblée et plus approfondie. Conclusions et perspectivesNos travaux sur la recherche du GS dans le CCR par la technique au BP et à l’IF-ICG ont montré que ces techniques étaient faisables mais que leurs sensibilités restaient limitées, en particulier chez les patients porteurs de tumeurs localement avancées. Dans la CP d’origine colorectale, nous avons montré que l’IF-ICG permettait d’améliorer la stadification de la CP des patients opérés de métastases péritonéales non mucineuses, de révéler des lésions non visibles dans les conditions standards et d’améliorer la radicalité de la chirurgie. Pour la détection de ganglions métastatiques, nous avons montré que l’IF-ICG permettait, in vivo, de détecter des ganglions infracliniques durant l’intervention et ex vivo, de guider l’analyse anatomopathologique de la pièce de résection. Enfin, nous pensons que ces observations pourraient nous permettre d’élaborer un nouveau concept de GS systémique par opposition au GS classique correspondant aux ganglions de drainage anatomique de la tumeur. Nous proposons que les capacités particulières de rétention de l’ICG dans les tissus cancéreux après injection par voie systémique pourraient permettre d’identifier des sites ganglionnaires métastatiques en dehors des sites de drainage révélés par les injections de marqueurs au sein ou en périphérie de la tumeur elle-même. Pour vérifier cette hypothèse, nous avons élaboré un nouveau protocole d’une étude clinique prospective dans laquelle la détection du GS systémique après injection iv d’ICG sera comparée aux résultats obtenus suite à l’injection péritumorale de BP. Les ganglions révélés par ces 2 techniques seront recherchés ex vivo sur la pièce de résection et analysés en anatomopathologie. Outre la démonstration de métastases ganglionnaires extra-anatomiques, nous pensons que cette approche systémique pourrait permettre de réduire le taux de FN observé suite à une injection péritumorale, notamment pour les tumeurs localement avancées, celles-ci pouvant perturber le drainage lymphatique selon les voies anatomiques. Summary:This thesis reports several clinical research works on the role of indocyanine green (ICG) fluorescence imaging (FI) for the detection of colorectal tumoral tissue. We first evaluate and compare the role of ICG-FI in the detection of sentinel lymph node (SLN) in colorectal cancer (CRC) in view to upstage patients. We have reported that both techniques (blue dye and ICG-FI) are similar in term of sensitivity with a high rate of false negative results. Therefore, we think that new approaches for SLN detection should be developped in CRC. Secondarily, we evaluate the role of ICG-FI after IV ICG injection for the detection of peritoneal carcinomatosis (PC) from CRC origin. We have reported that ICG-FI is able to detect non-mucinous PM with a sensitivity of 86%. Moreover, ICG-FI was able to guide surgery modifying the surgical procedure in 38% of patients. Thirdly, we investigate the role of ICG-FI for the detection lymph node (LN) metastases. We have reported that ICG-FI performed after IV ICG injection is able to detect LN metastases both in vivo and ex vivo. These findings have been confirmed in a retrospective study. Fiinally, we propose a new protocol to evaluate a new approach for SLN detection. In comparison with the standard technique using peritumoral injection, we propose a new approach using systemic (intravenous) ICG injection. We have called this approach the 'systemic' SLN detetion. This approach will be compared with the standard one using peritumoral blue dye injection. Sensitivity, specificity of both technique will be compared. In conclusion, the results of these preliminary clinical studies using ICG-FI for tumoral staging and treatment are encouraging and further larger studies should be performed.Doctorat en Sciences médicales (Médecine)
info:eu-repo/semantics/nonPublished
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Furlan, Benjamin, Harald Oberhofer, and Hannes Winner. "A Note on Merger and Acquisition Evaluation." Oxford University Press, 2016. http://dx.doi.org/10.1093/icc/dtv033.
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This note proposes the continuous treatment approach as a valuable alternative to propensity score matching for evaluating economic effects of merger and acquisitions (M&As). This framework allows considering the variation in treatment intensities explicitly, and it does not call for an arbitrary definition of cutoff values in traded ownership shares to construct a binary treatment indicator. We demonstrate the usefulness of this approach using data from European M&As and by relying on the example of post-M&A employment effects. The empirical exercise reveals some heterogeneities over the whole distribution of acquired ownership shares and across different types of M&As and country groups.
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Dixon, Wallace E. Jr, and P. Hull Smith. "Attentional Focus Moderates Habituation–Language Relationships: Slow Habituation May Be a Good Thing." Digital Commons @ East Tennessee State University, 2008. https://doi.org/10.1002/icd.490.
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An interesting paradox in the developmental literature has emerged in which fast-habituating babies tend to be temperamentally difficult and fast language learners, even though temperamentally difficult babies tend to be slow language learners. The purpose of the present investigation was to examine whether the paradoxical relationships among habituation, temperamental difficulty, and language acquisition could be mediated partly or wholly by infant attentional focus, because the latter also tends to correlate with temperamental difficulty and vocabulary size. Forty mother–infant dyads were followed from child age 5–20-months. Results replicated those of Tamis-LeMonda and Bornstein (Child Develop 1989, 60, 738–751): measures of visual habituation at 5 months were related to 13-month vocabulary. However, relationships between 5-month habituation and 20-month vocabulary were moderated by temperamental attentional focus. For children low in attentional focus, 5-month habituation was related negatively to 20-month productive vocabulary; whereas for children high in attentional focus, early habituation was positively related to later vocabulary. Results are consistent with a model of habituation in which volitional attentional focus overrides basic attentional mechanisms that occur during habituation.
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Dixon, Wallace E. Jr, and P. Hull Smith. "Who's Controlling Whom? Infant Contributions to Maternal Play Behavior." Digital Commons @ East Tennessee State University, 2003. https://doi.org/10.1002/icd.283.
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Because the way mothers play with their children may have significant impacts on children's social, cognitive, and linguistic development, researchers have become interested in potential predictors of maternal play. In the present study, 40 mother–infant dyads were followed from child age 5–20 months. Five-month habituation rate and 13 and 20 month temperamental difficulty were found to be predictive of maternal play quality at 20 months. The most parsimonious theoretical model was one in which habituation was mediated by temperamental difficulty in predicting mother play. Consistent with prior speculation in the literature, these data support the possibility that mothers adjust some aspects of their play behaviors to fit their children's cognitive and temperamental capabilities.
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Souza, Kamille LeÃo de. "A ExpansÃo das Commodities e a Suposta DesindustrializaÃÃo na RegiÃo Nordeste do Brasil no PerÃodo 1991-2012." Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11023.
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nÃo hÃNos dias atuais, à tema dos principais debates a desindustrializaÃÃo em curso nas economias que ainda nÃo atingiram alta renda per capita.VÃrios estudos foram realizados no Brasil sobre o assunto, mas a regiÃo Nordeste ainda carece de anÃlises nessa Ãrea. A hipÃtese central deste estudo à verificar se a economia nordestina se desindustrializou no perÃodo 1991-2012, com o crescimento contÃnuo de commodities na pauta de exportaÃÃes, aliado à maior participaÃÃo de produtos de conteÃdo tecnolÃgico mais relevante na pauta de importaÃÃes. A anÃlise foi realizada fazendo uso de dados da balanÃa comercial, exportaÃÃo e importaÃÃo, registrando a participaÃÃo das commodities e dos produtos industriais segundo a classificaÃÃo adotada pelo MDIC e OCDE (Alta, mÃdia-alta, mÃdia-baixa, baixa intensidade tecnolÃgica e produtos nÃo industrializados), do valor agregado pela indÃstria, pela participaÃÃo do emprego industrial no total e a renda (PIB). Para tal fim, foram calculados indicadores do comÃrcio exterior (Ãndice de ConcentraÃÃo das ExportaÃÃes-ICX, Ãndice de ConcentraÃÃo das ImportaÃÃes-ICM, Ãndice de Vantagem Comparativa Revelada em relaÃÃo ao saldo comercial-VCR, Taxa simples de Cobertura das importaÃÃes-TC e o Ãndice de ComÃrcio IntraindÃstria- CII) e regredido um modelo economÃtrico para verificar vestÃgios de desindustrializaÃÃo concernente à produÃÃo industrial. Os resultados indicam que a pauta de exportaÃÃo nordestina passa por uma reprimarizaÃÃo, que associada à maior presenÃa de produtos industriais com maior conteÃdo tecnolÃgico nas importaÃÃes apresenta sinais de desindustrializaÃÃo. NÃo à possÃvel concluir, no entanto, que a economia nordestina padeÃa da doenÃa holandesa, pois, na anÃlise do emprego industrial e do valor adicionado pela indÃstria no total da economia, nÃo apareceram sinais de perda de importÃncia do setor industrial no total, resultados esses corroborados pelo modelo economÃtrico regredido. Alguns segmentos industriais (tÃxtil, vestuÃrio e acessÃrios, mÃquinas, aparelhos e materiais elÃtricos) expressam, contudo, uma tendÃncia decrescente na evoluÃÃo do Ãndice de produÃÃo fÃsica industrial, o que pode indicar perda relativa desses ramos especificamente.
Nos dias atuais, à tema dos principais debates a desindustrializaÃÃo em curso nas economias que ainda nÃo atingiram alta renda per capita.VÃrios estudos foram realizados no Brasil sobre o assunto, mas a regiÃo Nordeste ainda carece de anÃlises nessa Ãrea. A hipÃtese central deste estudo à verificar se a economia nordestina se desindustrializou no perÃodo 1991-2012, com o crescimento contÃnuo de commodities na pauta de exportaÃÃes, aliado à maior participaÃÃo de produtos de conteÃdo tecnolÃgico mais relevante na pauta de importaÃÃes. A anÃlise foi realizada fazendo uso de dados da balanÃa comercial, exportaÃÃo e importaÃÃo, registrando a participaÃÃo das commodities e dos produtos industriais segundo a classificaÃÃo adotada pelo MDIC e OCDE (Alta, mÃdia-alta, mÃdia-baixa, baixa intensidade tecnolÃgica e produtos nÃo industrializados), do valor agregado pela indÃstria, pela participaÃÃo do emprego industrial no total e a renda (PIB). Para tal fim, foram calculados indicadores do comÃrcio exterior (Ãndice de ConcentraÃÃo das ExportaÃÃes-ICX, Ãndice de ConcentraÃÃo das ImportaÃÃes-ICM, Ãndice de Vantagem Comparativa Revelada em relaÃÃo ao saldo comercial-VCR, Taxa simples de Cobertura das importaÃÃes-TC e o Ãndice de ComÃrcio IntraindÃstria- CII) e regredido um modelo economÃtrico para verificar vestÃgios de desindustrializaÃÃo concernente à produÃÃo industrial. Os resultados indicam que a pauta de exportaÃÃo nordestina passa por uma reprimarizaÃÃo, que associada à maior presenÃa de produtos industriais com maior conteÃdo tecnolÃgico nas importaÃÃes apresenta sinais de desindustrializaÃÃo. NÃo à possÃvel concluir, no entanto, que a economia nordestina padeÃa da doenÃa holandesa, pois, na anÃlise do emprego industrial e do valor adicionado pela indÃstria no total da economia, nÃo apareceram sinais de perda de importÃncia do setor industrial no total, resultados esses corroborados pelo modelo economÃtrico regredido. Alguns segmentos industriais (tÃxtil, vestuÃrio e acessÃrios, mÃquinas, aparelhos e materiais elÃtricos) expressam, contudo, uma tendÃncia decrescente na evoluÃÃo do Ãndice de produÃÃo fÃsica industrial, o que pode indicar perda relativa desses ramos especificamente.
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Nilsson, Mathias, and Adam Ådnanes. "ICT-behov och -verktyg inom byggproduktion : En undersökning av användbarheten, användarvänligheten och implementeringsförutsättningar av ett ICT-program." Thesis, KTH, Byggteknik och design, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-125608.
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Byggproduktionen är, på grund av sina invecklade arbetsmoment och dynamiska arbetsplatser, drabbad av svåra informations- och kommunikationsproblem. Veidekke Sverige AB använder sig av virtuellt byggandet (VDC) för att lösa dessa hinder i utförandet av sina projekt. VDC tillämpar flera olika informations- och kommunikationstekniker (ICT) och har visat sig vara lönsamt vid projektering. Under projektering med VDC samlas alla beslutsbehöriga parter i ett interaktivt rum där information förmedlas snabbt och effektiv med hjälp av olika visualiseringstekniker. Då VDC saknar liknande arbetsmetoder som kan tillämpas i produktionen, används fortfarande traditionella informations- och kommunikationsprinciper. Genom ett samarbete med Veidekke implementerades ett ICT-program i ett bostadsprojekt för att undersöka hur dess funktioner påverkade de rådande informations- och kommunikations-problem. Observationer och intervjuer utfördes för att fastställa programmets användbarhet, användarvänlighet och implementeringsvillkor. Utvecklingen av olika molntjänster har revolutionerat möjligheterna att lagra och förvalta information. Genom att utnyttja molntjänster har olika ICT-program, såsom BIM 360 Field, utvecklats för att tillgodose byggproduktions informations- och kommunikationsbehov. Programmen skapar, via molntjänsten, ett virtuellt forum för arbetsplatsen där omfattande informationsmängder och byggnadsinformationsmodeller (BIM), kan lagras, för att sedan tillhandahållas, korrigeras och kommuniceras via mobila enheter såsom bärbara datorer, läsplattor och mobiltelefoner. BIM 360 Field erbjuder en rad olika funktioner med varierande användbarhet som bör anpassas till den svenska byggarbetsmarknaden för att öka användarvänligheten. Om programmet ska vara lönsamt krävs en fullständig implementering där majoriteten av projektets aktörer medverkar. Innan ny ICT tillämpas bör en välutformad implementeringsstrategi etableras för verksamheten.The construction industry suffers, due it´s dynamic work environment and intricate operations, from difficult information and communication problems. To solve these problems Veidekke incorporates the use of virtual design and construction (VDC) in its projects. VDC is a project method that applies the use of several different information and communication technologies and has proven to be profitable during the design phase. The use of VDC in the design phase assembles the decision-authorized parties in an interactive room where information can be shared quickly and effectively by utilizing visualization technology. VDC, however, lacks similar work processes for the construction phase of the project which still applies traditional information and communication principles. Through cooperation with Veidekke, an ICT-program was implemented in order to study its effect on the current information and communication problems. Observations and interviews were conducted in order to analyze the programs usability, user-friendliness and the conditions of implementation. The development of cloud computing services has revolutionized the possibilities to store and manage information. By utilizing the advantages of cloud services several ICT programs, such as BIM 360 Field, have been designed to address the information and communication problems of the construction industry. The programs create virtual forums wherein immense amounts of information can be stored, managed accessed by mobile units such as laptop computers, table pc and cellular phones. BIM 360 Field offers a range of different functions with high usability but should be adjusted to the Swedish construction industry in order to increase user-friendliness. In order for the program to be profitable it needs be fully implemented so that all construction parties are involved. Before new ICT can be introduced into a notoriously tech-conservative industry like construction, a well design implementation strategy needs to be established. The strategy should entail exactly which information and communication problems need to be addressed, what possibilities are available as well as how existing work processes and organizations need be conformed in order to maximize usability. The strategy should also contain an education and development plan.
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Beristain, Beristain Cecilia. "Ich sage "ich"." Diss., Ludwig-Maximilians-Universität München, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-183938.
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In der vorliegenden Arbeit untersuche ich verschiedene Funktionen, die das Wort 'Ich' in unserer Sprache einnehmen. In der Alltagssprache sprechen wir in vielen verschiedenen Weisen und Situationen über uns selbst. Dies ist verbunden mit verschiedenen Verwendungsweisen des Pronomens der ersten Person, das verschiedene Rollen in unserer Sprache haben kann. Wittgensteins Spätphilosophie ist bestrebt diese Rollen zu beschreiben. Dazu beobachtet Wittgenstein den Gebrauch der Alltagssprache.
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Carlos, Franciéle Schwanck. "Variabilidade química e climática no registro do Testemunho de Gelo Mount Johns – Antártica." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/139089.
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Esta tese interpreta o registro ambiental de um testemunho de gelo antártico pela análise de elementostraço. Esse testemunho de gelo, daqui em diante chamado Mount Johns (MJ), foi coletado no manto de gelo da Antártica Ocidental (79°55’28”S e 94°23’18”W; 91,20 m de comprimento) no verão austral de 2008/09. O testemunho foi descontaminado e subamostrado no Climate Change Institute (University of Maine – Maine /EUA). As primeiras 2137 amostras, correspondentes aos 45 m superiores do testemunho, foram analisadas no espectrômetro de massas Element 2 do CCI para 24 elementos-traço (Sr, Cd, Cs, Ba, La, Ce, Pr, Pb, Bi, U, As, Li, Al, S, Ca, Ti, V, Cr, Mn, Fe, Co, Na, Mg e K). Essa parte do testemunho representa 125 anos (1883–2008) de registro, segundo datação relativa baseada na variação sazonal nas concentrações de Na, Sr e S e na identificação dos principais eventos vulcânicos ocorridos no período. A taxa de acumulação média no local de amostragem foi 0,21 m a-1 em eq. H2O no mesmo período de tempo. As concentrações são controladas pelas variações climáticas sazonais (verão/inverno), por mudanças na circulação atmosféricas, por anomalias de temperatura, pela distância de transporte e pelas fontes naturais e antrópicas desses aerossóis. Baseada na análise dos fatores de enriquecimento crustal e marinho e em correlações de Pearson, as concentrações de Al, Ba, Ca, Fe, K, Mg, Mn, Na, S, Sr e Ti são de origem natural. Poeira e solo de fontes continentais, oriundas principalmente de áreas áridas na Austrália, Nova Zelândia e Patagônia, são consideradas importantes fontes de Al, Mg e Ti. Aerossóis marinhos do Pacífico Sul, transportados para o continente antártico pelas massas de ar, são fontes predominantes de Na, Sr, K, S e Ca. Para os elementos Ba, Fe e Mn, tanto fontes crustais como marinhas são significativas. Adicionalmente, Mn e S apresentam um aporte considerável de origem vulcânica (variando de 20–30% na concentração total). Os resultados também mostram enriquecimento significativo nas concentrações de arsênio devido a atividades antrópicas. Foi observado concentrações médias da ordem de 1,92 pg g-1 antes de 1900, aumentando até 7,94 pg g-1 em 1950. Este enriquecimento está diretamente relacionado às emissões da mineração e fundição de metais não-ferrosos na América do Sul, principalmente no Chile. A queda na concentração de arsênio observado no século XXI (concentração média de 1,94 pg g-1 após 1999) é interpretada como uma consequência à introdução de leis ambientais (em 1994) para reduzir emissões desse elemento durante os processos de mineração e fundição de cobre no Chile. O modelo de trajetórias HYSPLIT mostra uma clara variação sazonal no transporte entre os meses de verão/outono e inverno/primavera, onde predomina o transporte de oeste durante o ano todo e um transporte secundário de nordeste durante o verão/outono. As correlações entre as concentrações médias dos elementos-traço estudados e o modelo de reanálises ERA-Interim para o período 1979–2008, indicam que as concentrações de aerossóis marinhos são fortemente influenciadas pelas condições meteorológicas, por exemplo, por anomalias na temperatura da superfície do mar e concentração de gelo marinho.This thesis interprets the environmental record of an Antarctic ice core by the analysis of trace elements. This ice core, henceforward called Mount Johns (MJ), was collected in the West Antarctica ice sheet (79°55'28"S and 94°23'18"W; 91.20 m long) in the austral summer of 2008/09. The core was decontaminated and subsampled at the Climate Change Institute (CCI, University of Maine - Maine / USA). The first 2137 samples, corresponding to the upper 45 m of the core, were analyzed in the CCI's JRC Element 2 spectrometer for 24 trace elements (Sr, Cd, Cs, Ba, La, Ce, Pr, Pb, Bi, U, As, Li, Al, S, Ca, Ti, V, Cr, Mn, Fe, Co, Na, Mg and K). This part of the core represents a 125 years (1883– 2008) record, according to relative dating based on Na, Sr and S seasonal variations and on the identification of major volcanic events in the period. The mean accumulation rate for the sampling site was 0.21 m-1 in eq. H2O in the same time period. The concentrations are controlled by seasonal climatic changes (summer/winter), by changes in atmospheric circulation, temperature anomalies, the transport distance and the natural and anthropogenic sources of these aerosols. Based on analysis of crustal and marine enrichment factors and Pearson correlations, the Al, Ba, Ca, Fe, K, Mg, Mn, Na, S, Sr and Ti concentrations have natural origin. Dust and soil from continental sources, primarily coming from arid areas in Australia, New Zealand and Patagonia, are considered important sources of Al, Mg and Ti. South Pacific marine aerosols, transported to the Antarctic continent by air masses, are predominant sources of Na, Sr, K, S and Ca. For the elements Ba, Fe and Mn, both crustal and marine sources are significant. In addition, Mn and S show a considerable contribution of volcanic origin (ranging from 20-30% of the total concentration). The results also show significant enrichment in arsenic concentrations due to human activities. Before 1900 the mean concentration was approximately 1.92 pg g-1, rising to 7.94 pg g-1 in 1950. This enrichment is directly related to mining emissions and casting of non-ferrous metals in South America, mainly in Chile. The decrease in the arsenic concentration, observed in the twenty-first century (mean concentration of 1.94 pg g-1 after 1999) is interpreted as a consequence of the introduction of environmental laws (in 1994) to reduce emissions of this element during the cupper mining and smelting in Chile. The HYSPLIT trajectories model show a clear seasonal variation in transport between the summer/autumn all and winter/spring months, where predominates an eastward transport throughout the year and a secondary transport from the northeast during the summer/fall. Correlations between the mean concentrations of the studied trace elements and the ERA-Interim reanalysis models for the 1979-2008 period indicate that marine aerosols concentrations are heavily influenced by weather conditions, for example, by sea surface temperature and sea ice concentration anomalies.
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Ustun, Bulend. "3d Face Recognition." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/2/12609075/index.pdf.
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In this thesis, the effect of registration process is evaluated as well as several methods proposed for 3D face recognition. Input faces are in point cloud form and have noises due to the nature of scanner technologies. These inputs are noise filtered and smoothed before registration step. In order to register the faces an average face model is obtained from all the images in the database. All the faces are registered to the average model and stored to the database. Registration is performed by using a rigid registration technique called ICP (Iterative Closest Point), probably the most popular technique for registering two 3D shapes. Furthermore some variants of ICP are implemented and they are evaluated in terms of accuracy, time and number of iterations needed for convergence. At the recognition step, several recognition methods, namely Eigenface, Fisherface, NMF (Nonnegative Matrix Factorization) and ICA (Independent Component Analysis) are tested on registered and non-registered faces and the performances are evaluated.
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Souza, Kamille Leão de. "A expansão das commodities e a suposta desindustrialização na região nordeste do Brasil no período 1991-2012." reponame:Repositório Institucional da UFC, 2013. http://www.repositorio.ufc.br/handle/riufc/10105.
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SOUZA, Kamille Leão de. A expansão das commodities e a suposta desindustrialização na região Nordeste do Brasil no período 1991-2012. 2013. 127 f.: Dissertação (mestrado) - Universidade Federal do Ceará. Mestrado Acadêmico em Economia Rural (MAER). Centro de Ciências Agrárias. Fortaleza-CE. 2013Submitted by Francisco Helder Macêdo Rangel (fhelder@ufc.br) on 2014-10-10T17:07:16Z No. of bitstreams: 1 2013_dis_klsouza.pdf: 1329267 bytes, checksum: 189bb2778404c732a679703c10dc924a (MD5)
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Nowadays deindustrialization underway in economies that have not yet reached a high per capita income is the main theme in debates. Several studies were conducted to Brazil on this subject, but the Northeast still lacks analysis in this area. The central hypothesis of this study is to verify ig the Northeast economy was deindustrialized in the period 1991-2012, from the continued growth of commodities in totalexports couopled with the highest share of products with higher technological content in the imports. The analysis was carried out by using data on the trade balance, exports and imports, registering the share of commodities and industrial products, according to the classification adopted by OECD and MDI C (high, medium-high, medium-low, low-tech and unprocessed products), the value added by industry, the share of manufacturing employment and total income (GDP). To this end, we calculated indicators foreign trade (Export Concentration Index-ICX, Concentration Index of Import-ICM, Revealed Comparative Advantage Index over the trade balance-VCR, simple rate of coverage of imports and TC-Index of intra-industrytrade-CII and an econometric model was regressed to verify traces of deindustrialization in relation to industrial production. The results indicate that the northeast export tariff undergoes a reprimarization that, when associated with the increased presence of industrial products with higher technological content of imports, show signs of deindustrialization. However, it is not possible to come to the conclusion that the northeast economy suffers the dutch disease because signs of loss of importance on the industrial sector in total did not appear on the analysis of industrial employment and of the value added by industry in the totaleconomy. There, such results corroborated with the econometric model regressed. However, some industries (textile, clothing and accessories and machinery, equipment and material) showed a decreasing trend in the evolution of the physical industry production index, which may indicate a kind of loss.
Nos dias atuais, é tema dos principais debates a desindustrialização em curso nas economias que ainda não atingiram alta renda per capita. Vários estudos foram realizados no Brasil sobre o assunto, mas a região Nordeste ainda carece de análises nessa área. A hipótese central deste estudo é verificar se a economia nordestina se desindustrializou no per5íodo 1991-2012, com o crescimento contínuo de commodities na pauta de exportações, aliado à maior participação de produtos de conteúdo tecnológico mais relevante na pauta de importações. A análise foi realizada fazendo uso de dados da balança comercial, exportação e importação, registrando a participação das commodities e dos produtos industriais segundo a classificação adotada pelo MDIC e OCDE (Ala, méida-alta, média-baixa, baixa intensidade tecnológica e produtos não industrializados), do valor agregado pela indústria, pela participação do emprego industrial no total e a renda (PIB). Para tal fim, foram calculados indicadores do comércio exterior (Índice de Concentração das Exportações-ICX, Índice de Concentração das Importações-ICM, Índice de Vantagem comparativa Revelada em relação ao saldo comerciakl-VCR, Taxa simples de Cobertura das importações-TC e o Índice de Comércio Intraindústria-CII) e regredido um modelo econométrico para verificar vestígios de desindustrialização concernente à produção industrial. Os resultados indicam que a pauta de exportação nordestina passa por uma reprimarização, que associada à maior presença de produtos industriais com maior conteúdo tecnológico nas importações apresenta sinais de desindustrialização. Não é possível concluir, no entanto, que a economia nordestina padeça da doença holandesa, pois, na análise do emprego industrial e do valor adicionado pela indústria no total da economia, não apareceram sinais de perda de importância do setor industrial no total, resultados esses corroborados pelo modelo econométrico regredido. Alguns segmentos industriais (têxtil, vestuário e acessórios, máquinas, aparelhos e materiais elétricos) expressam, contudo, uma tendência decrescente na evolução do índice de produção física industrial, o que pode indicar perda relativa desses ramos especificamente.
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Nubila, Heloisa Brunow Ventura Di. "Aplicação das classificações CID-10 e CIF nas definições de deficiência e incapacidade." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/6/6132/tde-09042007-151313/.
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A Organização Mundial de Saúde tem hoje duas classificações de referência para a descrição dos estados de saúde: a CID-10 (Classificação Estatística Internacional de Doenças e Problemas Relacionados à Saúde) e a CIF (Classificação Internacional de Funcionalidade, Incapacidade e Saúde). A utilização da CIF vem sendo aguardada com grande expectativa pelas organizações de pessoas com deficiências e instituições relacionadas. A falta de definição clara de deficiência ou incapacidade tem sido apontada como um impedimento para a promoção de saúde de pessoas com deficiência. Este trabalho tem como objetivo apresentar definições de deficiência, discutindo a utilização da CID-10 e da CIF e a contribuição da CIF para melhorar a compreensão sobre definições de deficiência a partir do conceito de funcionalidade e dos fatores contextuais. Foram revisados alguns diferentes conceitos/definições de deficiência, bem como publicações envolvendo a aplicação da CIF. São apresentadas algumas categorias de diagnósticos de estados de saúde da CID-10 hoje utilizadas em alguns sistemas, além de elementos da recém-apresentada CIF, que podem contribuir para diferentes campos de aplicabilidade no que diz respeito ao entendimento das definições de deficiência ou incapacidade.The World Health Organization has nowadays two reference classifications for description of health conditions: ICD-10 (International Statistical Classification of Diseases and Health Related Problems) and ICF (International Classification of Functioning, Disability and Health). Organizations of people with disabilities and related institutions are waiting with high expectation for the ICF utilization. Lack of clear definition of disability is being pointed out as a deterrent for promoting the health of people with disabilities. The objective of this work is to evaluate definitions of disability, and discuss the use of ICD-10 and ICF and the contribution of ICF to improve understanding of definitions of disability through functioning and contextual factors. Some different definitions of disability have been reviewed, as well as publications involving ICF application. Diagnostic categories of health conditions of ICD-10 used in some systems are presented, as well as ICF components that could contribute for different fields of applicability regarding the understanding of definitions of disability.
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Beard, Rebecca. "'Ich schreibe [...] auf ein Förderband: Ich Ich Ich' : constructing authorship in the work of Günter Grass." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425420.
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Sukhorukov, Sergiy. "Ice-Ice and Ice-Steel Friction in Field and in Laboratory." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for bygg, anlegg og transport, 2013. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-23559.
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Friction is one of the key phenomena during the interaction of ice with offshore structures and ships, ice rafting and ridging processes, and the brittle compressive failure of ice. Therefore, knowledge of the ice friction laws and a better understanding of this phenomenon are needed for the design of safe and reliable offshore structures and successful operations in ice-infested waters. This thesis presents experimental studies on ice friction in the field and in the laboratory and can be divided into three parts: field study of ice friction and the effects of different parameters on the kinetic and static friction coefficients; investigation of geometrical stick-slip interaction between ice and stainless steel in small-scale laboratory tests; field investigation of the vertical ice forces exerted on isolated vertical piles frozen in a level sea due to changes in the water level. The first version of the experimental setup for the field tests to study ice friction was relatively simple and was used only in 2010. Significant modifications and improvements were made to the setup in 2011 that allowed us to better control the test conditions (i.e., velocity, normal load). The available range of sliding velocities (between 6 mm s-1 and 43 mm s-1) did not cover the whole range of our interest. Therefore, a new pulling mechanism was introduced in the tests in 2012 that allowed us to extend the sliding range up to 110 mm s-1. The field experiments were conducted with first year sea ice in the Barents Sea and in fjords at Spitsbergen during three springs (2010-2012). In September of 2012, the ice friction tests were performed with multiyear sea ice northeast of Greenland. Most of the tests were performed to investigate the friction between sea ice and sea ice, while the rest were to study the friction between sea ice and corroded steel. The aim of the study was to survey the most important factors that affect ice friction in field conditions and to determine whether the existing friction models correctly predict the dependences observed in the field tests. The effects of the sliding velocity (6 mm s-1to 105 mm s-1), air temperatures (-2°C to -20°C), normal load (300 N to 2000 N), presence of sea water in the interface, and ice grain orientation with respect to the sliding direction on the friction coefficient were investigated. The effect of the hold time on the static friction coefficient was also studied. The test campaigns showed that ice surface roughness is likely to be the most important parameter in determining the friction coefficient. Repeated sliding over the same track led to surface polishing and decreased the kinetic friction coefficient from 0.48 to 0.05. When sliding occurs between unsmoothed surfaces, the friction coefficient was found to be independent of the sliding velocity. As the contacting surfaces become smoother, the kinetic friction coefficient begins to depend on the velocity, as predicted by existing ice friction models. Some attempts were made to characterise ice surface irregularities and real contact area using two techniques: 1) the production of an ice surface cast and its further analysis using an optical microscope and 2) measurements of the pressure distribution and real contact area using tactile sensors. The static friction coefficient increases logarithmically with the hold time and changes from approximately 0.6 at 5 s to 1.26 at 960 s. The small-scale laboratory studies on the stick-slip interaction between ice and stainless steel were performed at the University Centre in Svalbard (UNIS). A specially designed device allowed us to study the effect of well controlled steel surface roughness on the interaction between ice and steel under various test conditions. The effects of the relative sliding rate (1.67 × 10-6 m s-1 to 0.83 × 10-3 m s-1), temperature (-5°C to -25°C) and applied constant pushing force were also investigated. Stick-slip interaction was always observed in the tests on samples with an arithmetic average roughness (Ra) between 2 μm and 15 μm. Both steady state sliding and stick-slip were observed in the tests on samples with the lowest (Ra = 2 μm) and the highest (Ra = 25.2 μm) roughness. The slip distance was found to be equal to the mean pitch profile (mean profile wavelength) for all velocities studied. The elasticity of the ice was found to be an important factor in the stick-slip interaction. The field studies of the vertical ice forces exerted on isolated vertical piles frozen in the ice were performed in Svea, Spitsbergen, in March of 2010. Four different piles made of steel and aluminium were used in the experiments. The piles were pushed through the ice using a hydraulic jack. The first peak load measured in the tests is associated with the onset of the ice-pile relative movement. Because we always observed failure at or very near the ice-pile interface, the first peak load can be treated as the strength of adhesion or the cohesive failure of ice in the vicinity of the interface. Elastic plate theory was used to estimate theoretically the vertical forces exerted on a pile.
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Sandström, Pontus. "Relationen mellan ICA-handlaren och ICA AB." Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167383.
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Syftet med denna uppsats var att, med hjälp av företagsekonomiska relationsteorier, undersöka och beskriva ICA-handlare som driver butiker i profilerna Nära- och Supermarkets relation till ICA AB. De handlare som ingick i studien driver butiker i Uppsalaområdet. Utifrån relationsteorier om engagemang och förtroende utformades och genomfördes intervjuer med ICA-handlare. Informationen från intervjuerna användes för att uppfylla studiens syfte och besvara frågeställningen. Studien visar att ICA-handlare som driver butiker inom profilerna Nära- och Supermarkets relation till ICA AB är bra.
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Coetzee, Coenraad J. W. "ICT convergence : impact on Namibian ICT operators." Thesis, Stellenbosch : Stellenbosch University, 2007. http://hdl.handle.net/10019.1/19806.
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Thesis (MBA) -- Stellenbosch University, 2007.Today we face a reality where existing power relations concerning economical, political and cultural institutions and forces are changing. It is about more than just the right to use a technology in itself; it is a matter of having, or not having, access to infonnation and knowledge. The use of information and communications technology (lCT) is an important and powerful tool when it comes to distributing and sharing these resources (Bridges.arg, 2006). The unequal distribution of and the differences in the possibility to use rer effectively are often referred to by the term digital divide (DDN, 2006). Does this sound quite pessimistic? However, a change is taking place since all countries on earth from the richest to the poorest are actually increasing their Ier usage. The problem is that the developed countries are using convergence (three separate communication sectors: information technology, telecommunications and broadcasting merging to become a single communication service sector) to escalate their access to and use of ICf at a much higher speed, which in fact widens the digi tal divide instead of shrinking it (Bridges.org, 2006). Today no country can afford to neglect investments in ICf if it wishes to raise its living standards or to prevent it from being left behind as other countries exploits the possibilities of ICf. Why is ICf considered to be an effective tool for bridging the international digita1 divide? On the United Nations Development Programme's website one can read: " .. .ICf is an increasi ngly powerful tool for participating in global markets; promoting political accountability; improving the delivery of basic services; and enhancing local development opportunities" (UNOP, 2003). These aspects can be of great importance for developing countries in their effort to gain economic development and improvements. Furthermore, it is also a question about every human's right to have access to infonnation (Sida, 2004). According to Steve Case (AOL Time Warner, Chainnan of the Board) every decade has some word associated with it. In the 'SOs, it was the PC. In the '90s, it was the Internet. For the rest of this decade, the key word is going to be convergence (Thompson, 2003). In Namibia a digital divide exists between income groups as well as between the country's rural and urban population. Namibia is sti ll far from providing equal access to information, but Namibia is well positioned to deploy ICf to its advantage. Namibia has a functional telecommunication infrastructure, political stability and an attractive economic environment for investors. However. the geographic and social challenges of Namibia require innovative approaches and considerable effort. Competition and convergence will improve the situation. recommended to expand the set of potential drivers and specifically focus on the relation between convergence and economic growth.
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Kjell, David. "ICD-patienters livskvalitet efter en ICD-implantation." Thesis, Malmö högskola, Fakulteten för hälsa och samhälle (HS), 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-25577.
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En implanterbar defibrillator (ICD) är nuförtiden en väl beprövad behandlingsmetod för patienter som överlevt ett hjärtstopp eller har en avancerad hjärtsjukdom och därmed har ökad risk för ventrikulära arytmier. Syftet med vårt arbete var att beskriva ICD-patienters livskvalitet och de livsomställningar som en ICD-implantation medförde. Studien genomfördes som en litteraturöversikt enligt Willman et al. Resultat visade att livet med en ICD innebar omställningar och förändringar som många patienter inte var helt förberedda på. En defibrilleringschock visade sig inverka negativt på livskvaliteten. Professionell sjukvårdspersonal och anhöriga hade en viktig roll att spela vad gäller stöd, information och utbildning. Sjukvårdspersonal kan behöva ytterligare utbildning för att kunna ta hand om patienterna och möta dem i deras situation. Ytterligare forskning kan vara av värde för att se hur patienternas livskvalitet ser ut på längre sikt.An implantable defibrillator is nowadays a well-known treatment for patients who survived a cardiac arrest or suffer from severe heart disease. The aim of our study was to describe ICD-patients quality of life and the life changes that come with the ICD-implantation. The study was conducted as a literature review pursuant to Willman et al. The result showed that patients living with an ICD needed to adapt to life changes that could occur. Defibrillation had a negative impact on quality of life. Medical staff and next of kin were important to provide support, information and education. All medical staff may need further education to properly manage the care of ICD-patients. Further research can be of value to evaluate patients’ quality of life in the long term.
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Lundberg, Johanna, and Caroline Ullman. "ICA likes you, do you like ICA?" Thesis, Malmö högskola, Fakulteten för kultur och samhälle (KS), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-23252.
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Idag finns det begränsade teorier som behandlar det postmoderna konsumtionssamhället utifrån ett medie- och kommunikationsvetenskaligt perspektiv. Syftet med examensarbetet är att undersöka spänningsfältet mellan ICA och högskolestudenter i ett konsumtionssamhälle genom att granska varumärkeskommunikationens betydelse på digitala plattformar. Materialinsamlingen är genomförd i form av kvalitativa intervjuer, med medarbetare på ICA, samt fokusgrupper med studenter. Med studien vill vi ge en inblick i hur kommunikationsprocesser strategiskt utformas för att nå rätt målgrupp, hur relationer vårdas och vad en god dialog innebär och har för framtida betydelser. Studien har analyserat det spänningsfält som ligger i grund till valet av konsumtion gällande matvaruhandel som högskolestudent. Studiens slutsatser visar på att det är en rad olika faktorer som är bidragande till att bygga upp en stark relation med ett företag.Today there is limited theories considering reasearch on the postmodern consumtion society from a media and communication perspective. The purpose with this thesis is to investigate the tension between ICA and Univeristy students in a consumption society through analysis brandbuilding communications meaning on digital platforms. The material to the thesis is collected by qualitative interviews, both with employees at ICA and focus groups with university students. With this thesis we want to give an insight of how communication processes strategically is designed to reach their target group, how relationships are nurtured and what a good dialogue means for future brand building. The study has analyzed the tension of what includes the choice of consumption when it comes to retail business from university students perspective. The conclusions indicate how there are a number of factors that are contributing to build a strong relationship with an organization.
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Chen, Jane Y. "Stress in ICU and non-ICU nurses." Thesis, Boston University, 1988. https://hdl.handle.net/2144/38019.
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Thesis (M.S.)--Boston UniversityPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
Nurses are subjected to occupational stress factors that can result in the syndrome of burnout. This study compared levels of burnout in nurses in a medical-surgical ICU setting to those in non-ICU medical-surgical settings. A randomized sample of 40 nurses of an urban hospital in Taiwan, twenty nurses in an ICU and 20 in five non-ICU settings (general medical-surgical wards), who returned the questionnaire used to measure burnout, were included in the study. The instrument utilized was the Staff Burnout Scale for Health Professionals. The study found no significant difference in levels of burnout in the two groups. Both groups in this study experienced a higher level of burnout than was reported in other studies in United States literature. In particular, two general medical-surgical wards which had high patient/nurse ratios, had very high levels of burnout. The study also found that all nurses with lower educational levels and ICU nurses with more years of work experience had more burnout.
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Desprez, Alain. "Caractérisation moléculaire et élémentaire des produits pétroliers lourds." Thesis, Pau, 2014. http://www.theses.fr/2014PAUU3052.
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Les pétroles utilisés en raffinage étant de plus en plus lourds et chargés en métaux et hétéroélements, il est d’une grande importance pour les activités de raffinage de connaître la spéciation de ces espèces au sein des produits pétroliers et leurs comportements durant les procédés de raffinage. Afin d’apporter des réponses à cette problématique des techniques de caractérisation élémentaire et moléculaire ont été utilisées notamment par ICP MS Haute Résolution et FT ICR MS respectivement. Ces techniques analytiques sont appliquées à différents échantillons pétroliers provenant parfois de procédés de raffinage et les informations obtenues au niveau élémentaire et moléculaire sont utilisées de manières complémentaires pour améliorer notre compréhension des mécanismes se produisant au sein de nos échantillons durant les activités de raffinageThe crude oils available for the refining industry are heavier and heavier and more concentrated in metals and heteroelements. It is thus of great importance to study the speciation of these species within the petroleum products and their behavior during the refining processes. To answer that problematic, elemental and molecular characterization techniques have been used, mainly High Resolution ICP MS and FT ICR MS for the elemental and molecular characterization respectively. The analytical techniques quoted are used for the analysis of several petroleum products sometimes originating from refining processes and the information obtained at the elemental and molecular level are combined to improve our understanding of the mechanisms occurring within our samples during refining activities
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Howe, Rachel. "Ice XI : the ordered form of ICE Ih." Thesis, University of Birmingham, 1988. http://etheses.bham.ac.uk//id/eprint/5255/.
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The history of the development of the understanding of the statistical arrangement of hydrogen bonds in ice Ih and the discovery of the transition at 72 K to the ordered phase, ice XI, catalysed by alkali hydroxide doping, is reviewed. Possible ordered arrangements of hydrogen bonds are discussed and enumerated. A theory is presented relating the entropy and permittivity of partially ordered ice to the degree of order. The apparatus developed for dielectric experiments on KOH-doped ice is described. The results of such measurements for polycrystalline specimens and one single crystal are presented. Measurements above the transition reveal that the main charge carriers are OH\(^-\) ions, with a temperature-independent mobility of approximately 10\(^-\)\(^1\)\(^0\) m\(^2\) v\(^-\)\(^1\) s\(^-\)\(^1\). The transformation to the ordered phase starts when the sample is cooled below about 65 K, and once started can be speeded up by heating the sample to 67-70 K: the static permittivity and the a.c. conductivity slowly decrease. Neutron powder diffraction experiments were performed on HRDP at ISIS. After one unsuccessful experiment, dielectric measurements on powder samples showed the importance of excluding CO\(_2\) during preparation. In a second experiment the structure of ice XI was confirmed and the lattice parameters determined for the first time.
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Andersson, Lars-Olof. "Ice accretion and ice adhesion to polymer material." Licentiate thesis, Luleå tekniska universitet, 1993. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-26519.
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