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Journal articles on the topic 'ICL-model'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Kuhlmann, Emily Hope, and Amy Lynn Conrad. "Word Reading in Boys With Isolated Oral Clefts: Comparison to Unaffected Average and Dyslexic Readers Using the Dual-Route Model." Cleft Palate-Craniofacial Journal 57, no. 3 (2019): 310–20. http://dx.doi.org/10.1177/1055665619867015.

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Objective: To examine word reading performance between boys with isolated cleft lip and/or palate (iCL/P), unaffected average reading (uAR), and unaffected impaired reading (uIR), using the dual-route model. Design: Case/control study. Setting: University children’s hospital. Participants: Males, between the ages of 8 to 11 years, with iCL/P (n = 26), uIR (n = 33), or uAR (n = 28). Methods: Single word reading and achievement were evaluated. Analyses of variance and analyses of covariance evaluated group differences in achievement. Medical records were reviewed for iCL/P participants for audio

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2

Fisher, Laura A., Mika Bessho, and Tadayoshi Bessho. "Processing of a Psoralen DNA Interstrand Cross-link by XPF-ERCC1 Complex in Vitro." Journal of Biological Chemistry 283, no. 3 (2007): 1275–81. http://dx.doi.org/10.1074/jbc.m708072200.

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The processing of stalled forks caused by DNA interstrand cross-links (ICLs) has been proposed to be an important step in initiating mammalian ICL repair. To investigate a role of the XPF-ERCC1 complex in this process, we designed a model substrate DNA with a single psoralen ICL at a three-way junction (Y-shaped DNA), which mimics a stalled fork structure. We found that the XPF-ERCC1 complex makes an incision 5′ to a psoralen lesion on Y-shaped DNA in a damage-dependent manner. Furthermore, the XPF-ERCC1 complex generates an ICL-specific incision on the 3′-side of an ICL. The ICL-specific 3′-i

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3

Carver, Glenn. "A spectral meteorological model on the ICL DAP." Parallel Computing 8, no. 1-3 (1988): 121–26. http://dx.doi.org/10.1016/0167-8191(88)90115-9.

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4

Zholos, Alexander, Benjamin Beck, Vadym Sydorenko, et al. "Ca2+- and Volume-sensitive Chloride Currents Are Differentially Regulated by Agonists and Store-operated Ca2+ Entry." Journal of General Physiology 125, no. 2 (2005): 197–211. http://dx.doi.org/10.1085/jgp.200409161.

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Using patch-clamp and calcium imaging techniques, we characterized the effects of ATP and histamine on human keratinocytes. In the HaCaT cell line, both receptor agonists induced a transient elevation of [Ca2+]i in a Ca2+-free medium followed by a secondary [Ca2+]i rise upon Ca2+ readmission due to store-operated calcium entry (SOCE). In voltage-clamped cells, agonists activated two kinetically distinct currents, which showed differing voltage dependences and were identified as Ca2+-activated (ICl(Ca)) and volume-regulated (ICl, swell) chloride currents. NPPB and DIDS more efficiently inhibite

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Shi, Hongwei, Zhenming Jiang, Teng Wang, Yongting Chen, and Feng Cao. "Elevated Swelling-Activated Chloride Current Densities in Hypertrophied Ventricular Myocytes in a Rabbit Heart Failure Model." Heart Surgery Forum 22, no. 2 (2019): E107—E111. http://dx.doi.org/10.1532/hsf.2255.

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Background: The status of the swelling-activated chloride channel (ICl, swell) during heart failure remains unclear. This study aimed to investigate whether the ICl, swell activity is altered during heart failure and to determine how the ICl, swell influences atrial arrhythmias of the failing heart. Methods: We established a heart failure rabbit model and analyzed the hemodynamic indicators 8 weeks after myocardial infarction, which include left ventricular systolic pressure (LVSP) and left ventricular end-diastolic pressure (LVDEP). Five untreated rabbits and 5 receiving a sham operatio

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Kojima, Takashi, Yoshihiro Kitazawa, Tomoaki Nakamura, et al. "Prospective Randomized Multicenter Comparison of the Clinical Outcomes of V4c and V5 Implantable Collamer Lenses: A Contralateral Eye Study." Journal of Ophthalmology 2018 (September 5, 2018): 1–6. http://dx.doi.org/10.1155/2018/7623829.

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Purpose. To compare the visual and refractive outcomes and night vision performance questionnaire results between V4c and V5 implantable Collamer lenses in a prospective, randomized, multicenter study.Settings. Four refractive surgery centers.Design. Prospective randomized multicenter single-masked comparative study.Methods. Twenty-three patients were enrolled in this study. A conventional V4c model (EVO Visian ICL) was implanted in one eye, and a V5 model (EVO+ Visian ICL), which has a larger optic diameter than the V4c model, was implanted in the contralateral eye. The uncorrected distance v

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DiFranco, Marino, Alvaro Herrera, and Julio L. Vergara. "Chloride currents from the transverse tubular system in adult mammalian skeletal muscle fibers." Journal of General Physiology 137, no. 1 (2010): 21–41. http://dx.doi.org/10.1085/jgp.201010496.

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Chloride fluxes are the main contributors to the resting conductance of mammalian skeletal muscle fibers. ClC-1, the most abundant chloride channel isoform in this preparation, is believed to be responsible for this conductance. However, the actual distribution of ClC-1 channels between the surface and transverse tubular system (TTS) membranes has not been assessed in intact muscle fibers. To investigate this issue, we voltageclamped enzymatically dissociated short fibers using a two-microelectrode configuration and simultaneously recorded chloride currents (ICl) and di-8-ANEPPS fluorescence s

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8

Rothfuss, Andreas, and Markus Grompe. "Repair Kinetics of Genomic Interstrand DNA Cross-Links: Evidence for DNA Double-Strand Break-Dependent Activation of the Fanconi Anemia/BRCA Pathway." Molecular and Cellular Biology 24, no. 1 (2004): 123–34. http://dx.doi.org/10.1128/mcb.24.1.123-134.2004.

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ABSTRACT The detailed mechanisms of DNA interstrand cross-link (ICL) repair and the involvement of the Fanconi anemia (FA)/BRCA pathway in this process are not known. Present models suggest that recognition and repair of ICL in human cells occur primarily during the S phase. Here we provide evidence for a refined model in which ICLs are recognized and are rapidly incised by ERCC1/XPF independent of DNA replication. However, the incised ICLs are then processed further and DNA double-strand breaks (DSB) form exclusively in the S phase. FA cells are fully proficient in the sensing and incision of

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9

Shen, I. Y. "Hybrid Damping Through Intelligent Constrained Layer Treatments." Journal of Vibration and Acoustics 116, no. 3 (1994): 341–49. http://dx.doi.org/10.1115/1.2930434.

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This paper is to propose a viable hybrid damping design that integrates active and passive dampings through intelligent constrained layer (ICL) treatments. This design consists of a viscoelastic shear layer sandwiched between a piezoelectric constraining cover sheet and the structure to be damped. According to measured vibration response of the structure, a feedback controller regulates axial deformation of the piezoelectric layer to perform active vibration control. In the meantime, the viscoelastic shear layer provides additional passive damping. The active damping component of this design w

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Youds, Jillian L., Louise J. Barber, and Simon J. Boulton. "C. elegans: A model of Fanconi anemia and ICL repair." Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 668, no. 1-2 (2009): 103–16. http://dx.doi.org/10.1016/j.mrfmmm.2008.11.007.

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11

ROBINSON, DARRYL. "The Identity Crisis of International Criminal Law." Leiden Journal of International Law 21, no. 4 (2008): 925–63. http://dx.doi.org/10.1017/s0922156508005463.

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AbstractThe general narrative of international criminal law (ICL) declares that the system adheres in an exemplary manner to the fundamental principles of a liberal criminal justice system. Recent scholarship has increasingly questioned the adherence of various ICL doctrines to such principles. This article scrutinizes the discourse of ICL – the assumptions and forms of argumentation that are regarded as sound reasoning with appropriate liberal aims. This article argues that ICL, in drawing on national criminal law and international human rights law, absorbed contradictory assumptions and meth

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Vandenberg, J. I., G. C. Bett, and T. Powell. "Contribution of a swelling-activated chloride current to changes in the cardiac action potential." American Journal of Physiology-Cell Physiology 273, no. 2 (1997): C541—C547. http://dx.doi.org/10.1152/ajpcell.1997.273.2.c541.

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The purpose of this investigation was to determine to what extent the swelling-activated Cl- current (ICl,swell) contributes to swelling-induced changes in the resting membrane potential and action potential duration (APD) in ventricular myocytes. Action potentials were recorded from guinea pig ventricular myocytes using conventional whole cell recording techniques. Cell swelling caused initial lengthening followed by a variable shortening of APD. In 59% of cells this secondary APD shortening had a 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS)-sensitive component, consistent with a c

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Laganà, Antonio, Osvaldo Gervasi, Stefano Crocchianti, Ernesto Garcia, Guillermo Ochoa De Aspuru, and José M. Alvariño. "Cooperative mechanisms for the H + ICl reaction and their significance for the K + ICl experiment." Canadian Journal of Chemistry 72, no. 3 (1994): 919–27. http://dx.doi.org/10.1139/v94-119.

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To characterize the dynamics of halogen centre reactions, we have investigated the H + ICl system. In particular, we have focused our attention on the importance of indirect atom–diatom reactivity in determining the macroscopic and microscopic branching of a reaction. An analysis of opacity functions and trajectory plots evaluated for different collision angles and isotopic variants evidenced the occurrence of cooperative reactive mechanisms in which an atom of the target diatom favours reaction with the other end of the molecule. Two limiting cooperative mechanisms were singled out and associ

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Hartzell, H. C. "Activation of different Cl currents in Xenopus oocytes by Ca liberated from stores and by capacitative Ca influx." Journal of General Physiology 108, no. 3 (1996): 157–75. http://dx.doi.org/10.1085/jgp.108.3.157.

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Xenopus oocytes are an excellent model system for studying Ca signaling. The purpose of this study was to characterize in detail the Ca-activated Cl currents evoked by injection of inositol 1,4,5-trisphosphate (IP3) into Xenopus oocytes voltage-clamped with two microelectrodes. Injection of IP3 into Xenopus oocytes activates two different Ca-activated Cl currents. ICl-1 is stimulated rapidly (within 5 s after IP3 injection), exhibits time-dependent activation upon depolarization, a linear instantaneous IV relationship with a reversal potential near ECl, and a curvilinear activation curve with

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15

Sundari, Rita, Omnia Salah Ahmed, Abdurrahman Abdurrahman, and Kartini Herlina. "APPLICATION OF INQUIRY BASED LEARNING MODEL USING STEM APPROACH TO REDUCE STUDENTS' INTRINSIC COGNITIVE LOAD." INSECTA: Integrative Science Education and Teaching Activity Journal 2, no. 1 (2021): 87–94. http://dx.doi.org/10.21154/insecta.v2i1.2482.

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This study is an experimental research using a quasi-experimental design with the type of non-equivalent control group pretest-posttest. This research aims to reduce Intrinsic Cognitive Load (ICL) through Inquiry Based Learning (IBL) model based STEM approach. This research was conducted at SMA Negeri 1 Seputih Banyak with the research subjects of class X IPA 1 students and X IPA 4. An data Intrinsic Cognitive Load obtained from essay the pretest-posttest (Task Complexity worksheet). Cognitive load test data analysis was performed using the data normality test, N-gain test and hypothesis test

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Aron, Allegra T., Marie C. Heffern, Zachery R. Lonergan, et al. "In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection." Proceedings of the National Academy of Sciences 114, no. 48 (2017): 12669–74. http://dx.doi.org/10.1073/pnas.1708747114.

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Iron is an essential metal for all organisms, yet disruption of its homeostasis, particularly in labile forms that can contribute to oxidative stress, is connected to diseases ranging from infection to cancer to neurodegeneration. Iron deficiency is also among the most common nutritional deficiencies worldwide. To advance studies of iron in healthy and disease states, we now report the synthesis and characterization of iron-caged luciferin-1 (ICL-1), a bioluminescent probe that enables longitudinal monitoring of labile iron pools (LIPs) in living animals. ICL-1 utilizes a bioinspired endoperox

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17

Barnes, S., and B. Hille. "Ionic channels of the inner segment of tiger salamander cone photoreceptors." Journal of General Physiology 94, no. 4 (1989): 719–43. http://dx.doi.org/10.1085/jgp.94.4.719.

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Cone photoreceptors were isolated enzymatically and their ionic currents studied by the whole-cell, gigaseal voltage-clamp technique. Five nonsynaptic currents were identified. A prominent, poorly selective cation current, Ih, activated after a delay during hyperpolarizations and then deactivated with a delay on return to potentials greater than -50 mV. An empirical model for Ih gating kinetics is developed with three open and two closed states. Depolarization elicits a small, voltage-gated calcium current (ICa). Block by nitrendipine, nickel, cadmium, and cobalt, increase of current with bari

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18

Ka, Jaejin, and Seokmin Shin. "Photodissociation Dynamics of Heteronuclear Diatomic Ion (ICl-) in a Linear-Chain Model." Journal of Physical Chemistry A 102, no. 21 (1998): 3820–27. http://dx.doi.org/10.1021/jp980798x.

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19

Petryk, M. WP, and B. R. Henry. "Overtone intensities in neopentane and tetramethylsilane." Canadian Journal of Chemistry 79, no. 3 (2001): 279–90. http://dx.doi.org/10.1139/v01-015.

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The CH vibrational overtone transitions of vapour phase neopentane-d0, -d6, -d9, and tetramethylsilane (TMS) are investigated via conventional absorbance spectroscopy and intracavity laser photoacoustic spectroscopy (ICL-PAS). The CH stretching overtones of neopentane-d0 are observed in the energy range Δ VCH = 39 (8 400 to 22 000 cm1) and in the range Δ VCH = 38 for the remaining neopentanes and TMS. While we have extended the range of previous studies, our main focus in this work has been on overtone intensities. The oscillator strengths of the neopentane-d0 overtone transitions are deter

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20

Alemdehy, Mir Farshid, Jurgen R. Haanstra, Hans W. J. de Looper, et al. "ICL-induced miR139-3p and miR199a-3p have opposite roles in hematopoietic cell expansion and leukemic transformation." Blood 125, no. 25 (2015): 3937–48. http://dx.doi.org/10.1182/blood-2014-11-612507.

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Key Points miR-139-3p and miR-199a-3p, induced by ICL-induced damage, respectively, cause a loss and gain of hematopoietic progenitors. miR-199a-3p is an onco-microRNA (onco-miR) causing AML in a Cebpa-deficient mouse model. Target genes of miR-199a-3p include PRDX6, RUNX1, and SUZ12.

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Tañá-Rivero, Pedro, Francisco Pastor-Pascual, Marceliano Crespo, José L. Rodríguez-Prats, José J. Muñoz-Tomás, and Robert Montés-Micó. "Posterior-Chamber Phakic Intraocular Lens Implantation in Patients over 40 Years of Age." Journal of Ophthalmology 2020 (June 29, 2020): 1–8. http://dx.doi.org/10.1155/2020/7457902.

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Purpose. To assess the efficacy, safety, and predictability of the Visian Implantable Collamer Lens (ICL) model having a central port in patients over 40 years of age. Methods. This study included 33 eyes from 21 patients who underwent V4c ICL implantation for the correction of myopia and myopic astigmatism. We assessed uncorrected (UDVA) and corrected (CDVA) distance visual acuity, refraction, intraocular pressure (IOP), endothelial cell density (ECD), vault, and adverse events occurring over a 1-year period. Results. Mean age of the patients at the time of implantation was 43.52 ± 4.49 years

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Christenson, Elizabeth, Virginia L. Jin, Marty R. Schmer, Robert B. Mitchell, and Daren D. Redfearn. "Soil Greenhouse Gas Responses to Biomass Removal in the Annual and Perennial Cropping Phases of an Integrated Crop Livestock System." Agronomy 11, no. 7 (2021): 1416. http://dx.doi.org/10.3390/agronomy11071416.

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Diversifying agronomic production systems by combining crops and livestock (i.e., Integrated Crop Livestock systems; ICL) may help mitigate the environmental impacts of intensive single-commodity production. In addition, harvesting row-crop residues and/or perennial biomass could increase the multi-functionality of ICL systems as a potential source for second-generation bioenergy feedstock. Here, we evaluated non-CO2 soil greenhouse gas (GHG) emissions from both row-crop and perennial grass phases of a field-scale model ICL system established on marginally productive, poorly drained cropland i

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Henden, Nicholas A., Ewald Puchwein, and Debora Sijacki. "The baryon content of groups and clusters of galaxies in the FABLE simulations." Monthly Notices of the Royal Astronomical Society 498, no. 2 (2020): 2114–37. http://dx.doi.org/10.1093/mnras/staa2235.

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ABSTRACT We study the gas and stellar mass content of galaxy groups and clusters in the fable suite of cosmological hydrodynamical simulations, including the evolution of their central brightest cluster galaxies (BCGs), satellite galaxies, and intracluster light (ICL). The total gas and stellar mass of fable clusters are in good agreement with observations and show negligible redshift evolution at fixed halo mass for $M_{500} \gtrsim 3 \times 10^{14} \, \mathrm{M}_{\odot }$ at z ≲ 1, in line with recent findings from Sunyaev–Zel’dovich (SZ)-selected cluster samples. Importantly, the simulation

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Ping, Shuqiu, Dayou Liu, Bo Yang, Yungang Zhu, Hechang Chen, and Zheng Wang. "Community Detection in Signed Networks Based on the Signed Stochastic Block Model and Exact ICL." IEEE Access 7 (2019): 53667–76. http://dx.doi.org/10.1109/access.2019.2891968.

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Mitchell, P. W., and M. T. Dove. "SHAMGAR's OXGOAD: A new approach to the problem of resolution corrections for triple-axis neutron inelastic scattering data using parallel processors." Journal of Applied Crystallography 18, no. 6 (1985): 493–98. http://dx.doi.org/10.1107/s0021889885010767.

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One problem in the analysis of triple-axis neutron inelastic scattering data is the large numerical computations involved in applying full resolution corrections, which in one extreme involves an often-repeated four-dimensional numerical integral. A program called SHAMGAR has been written for an ICL Distributed Array Processor that will both calculate the full convolution of a model scattering function with the resolution function and allow refinement of the model simultaneously to many sets of experimental data by a non-linear least-squares fit. Sample results and performance figures are give

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Gkotzamanidou, Maria, Masood A. Shammas, Evangelos Terpos, et al. "Disease-Associated Changes In The Repair Efficiency Of Double Strand Breaks Affect Melphalan Sensitivity Of The Bone Marrow Plasma Cells and Correlate With The Clinical Outcome Of Anti-Myeloma Therapy." Blood 122, no. 21 (2013): 3723. http://dx.doi.org/10.1182/blood.v122.21.3723.3723.

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Abstract Melphalan is an interstrand cross-link (ICL)-inducing agent and one of the most active chemotherapeutic drugs in the treatment of patients with multiple myeloma (MM). There is clear evidence that the formation and subsequent persistence of ICL correlates with its cytotoxicity. Previous studies have established that during ICL repair, replication forks stall at the ICL inducing the formation of a lethal form of DNA damage (DNA double-strand breaks, DSBs), which is repaired mainly by homologous recombination (HR) and non-homologous end joining (NHEJ). In this report, we investigated the

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Corneli, Marco, Pierre Latouche, and Fabrice Rossi. "Exact ICL maximization in a non-stationary temporal extension of the stochastic block model for dynamic networks." Neurocomputing 192 (June 2016): 81–91. http://dx.doi.org/10.1016/j.neucom.2016.02.031.

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Pigeau, A., and M. Gelgon. "Organizing a personal image collection with statistical model-based ICL clustering on spatio-temporal camera phone meta-data." Journal of Visual Communication and Image Representation 15, no. 3 (2004): 425–45. http://dx.doi.org/10.1016/j.jvcir.2004.04.002.

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WANG, SHU-JIE, LAI-HUA XIE, BIN HENG, and YAN-QIANG LIU. "Classification of potassium and chlorine ionic currents in retinal ganglion cell line (RGC-5) by whole-cell patch clamp." Visual Neuroscience 29, no. 6 (2012): 275–82. http://dx.doi.org/10.1017/s0952523812000272.

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AbstractRetinal ganglion cell line (RGC-5) has been widely used as a valuable model for studying pathophysiology and physiology of retinal ganglion cells in vitro. However, the electrophysiological characteristics, especially a thorough classification of ionic currents in the cell line, remain to be elucidated in details. In the present study, we determined the resting membrane potential (RMP) in RGC-5 cell line and then identified different types of ionic currents by using the whole-cell patch-clamp technique. The RMP recorded in the cell line was between −30 and −6 mV (−17.6 ± 2.6 mV, n = 10

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Wang, Xuan, Daniel J. Jacob, Sebastian D. Eastham, et al. "The role of chlorine in global tropospheric chemistry." Atmospheric Chemistry and Physics 19, no. 6 (2019): 3981–4003. http://dx.doi.org/10.5194/acp-19-3981-2019.

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Abstract. We present a comprehensive simulation of tropospheric chlorine within the GEOS-Chem global 3-D model of oxidant–aerosol–halogen atmospheric chemistry. The simulation includes explicit accounting of chloride mobilization from sea salt aerosol by acid displacement of HCl and by other heterogeneous processes. Additional small sources of tropospheric chlorine (combustion, organochlorines, transport from stratosphere) are also included. Reactive gas-phase chlorine Cl*, including Cl, ClO, Cl2, BrCl, ICl, HOCl, ClNO3, ClNO2, and minor species, is produced by the HCl+OH reaction and by heter

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Forrest, Abigail S., Talia C. Joyce, Marissa L. Huebner, et al. "Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension." American Journal of Physiology-Cell Physiology 303, no. 12 (2012): C1229—C1243. http://dx.doi.org/10.1152/ajpcell.00044.2012.

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Pulmonary artery smooth muscle cells (PASMCs) are more depolarized and display higher Ca2+ levels in pulmonary hypertension (PH). Whether the functional properties and expression of Ca2+-activated Cl− channels (ClCa), an important excitatory mechanism in PASMCs, are altered in PH is unknown. The potential role of ClCa channels in PH was investigated using the monocrotaline (MCT)-induced PH model in the rat. Three weeks postinjection with a single dose of MCT (50 mg/kg ip), the animals developed right ventricular hypertrophy (heart weight measurements) and changes in pulmonary arterial flow (pu

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Loubser, S. I., A. Babul, H. Hoekstra, Y. M. Bahé, E. O’Sullivan, and M. Donahue. "Dynamical masses of brightest cluster galaxies I: stellar velocity anisotropy and mass-to-light ratios." Monthly Notices of the Royal Astronomical Society 496, no. 2 (2020): 1857–80. http://dx.doi.org/10.1093/mnras/staa1682.

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ABSTRACT We investigate the stellar and dynamical mass profiles in the centres of 25 brightest cluster galaxies (BCGs) at redshifts of 0.05 ≤ z ≤ 0.30. Our spectroscopy enables us to robustly measure the Gauss–Hermite higher order velocity moments h3 and h4, which we compare to measurements for massive early-type galaxies, and central group galaxies. We measure positive central values for h4 for all the BCGs. We derive the stellar mass-to-light ratio ($\Upsilon _{\star \rm DYN}$), and velocity anisotropy (β) based on a multi-Gaussian expansion (MGE) and axisymmetric Jeans Anisotropic Methods (

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Gupta, Nirzari, Vivek K. Vyas, Bhumika Patel, and Manjunath Ghate. "Predictive 3D-QSAR and HQSAR model generation of isocitrate lyase (ICL) inhibitors by various alignment methods combined with docking study." Medicinal Chemistry Research 23, no. 6 (2013): 2757–68. http://dx.doi.org/10.1007/s00044-013-0865-0.

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TIWARY, AMIT S., PARTHA SARATHI SENGUPTA, and ASOK K. MUKHERJEE. "MODELING THE GROUND STATE GEOMETRY AND ESTIMATING THE CHARGE TRANSFER TRANSITION ENERGY OF THE TOLUENE–ICl MOLECULAR COMPLEX BY AB INITIO AND DFT METHODS." Journal of Theoretical and Computational Chemistry 07, no. 03 (2008): 331–46. http://dx.doi.org/10.1142/s0219633608003782.

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Out of several plausible isomeric structures of the toluene–ICl charge transfer (CT) complex, the most feasible one was determined by a detailed ab initio and DFT study at the HF, B3LYP, and mPW1PW91 levels using 6-31++G(d, p) basis set. Potential energy surface scans were performed with six possible structures ( I and Cl facing the o-, m-, and p-carbon atoms of toluene separately); the structures at the local minima of the surfaces were subjected to frequency calculation and the ones having no negative frequency were accepted as the real structure in the ground state. These structures were th

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Sripanich, Yantarat, Maxwell Weinberg, Nicola Krähenbühl, Chamnanni Rungprai, Charles L. Saltzman, and Alexej Barg. "Change in the First Cuneiform–Second Metatarsal Distance After Simulated Ligamentous Lisfranc Injury Evaluated by Weightbearing CT Scans." Foot & Ankle International 41, no. 11 (2020): 1432–41. http://dx.doi.org/10.1177/1071100720938331.

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Background: This study aimed to investigate the widening between the first cuneiform (C1) and second metatarsal (M2) in a Lisfranc ligamentous complex (LLC) joint injury model subjected to successive ligament dissections evaluated by weightbearing computed tomography (CT) scans. Methods: Twenty-four intact cadaveric feet served as the control (condition 1). Each component of the LLC (dorsal, interosseous, and plantar ligaments—conditions 2, 3, and 4, respectively) were then sequentially dissected. The specimens were equally randomized to 1 of 3 additional dissections (first or second tarsometa

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de Santiago, Jose Antonio, Keith Nehrke, and Jorge Arreola. "Quantitative Analysis of the Voltage-dependent Gating of Mouse Parotid ClC-2 Chloride Channel." Journal of General Physiology 126, no. 6 (2005): 591–603. http://dx.doi.org/10.1085/jgp.200509310.

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Various ClC-type voltage-gated chloride channel isoforms display a double barrel topology, and their gating mechanisms are thought to be similar. However, we demonstrate in this work that the nearly ubiquitous ClC-2 shows significant differences in gating when compared with ClC-0 and ClC-1. To delineate the gating of ClC-2 in quantitative terms, we have determined the voltage (Vm) and time dependence of the protopore (Pf) and common (Ps) gates that control the opening and closing of the double barrel. mClC-2 was cloned from mouse salivary glands, expressed in HEK 293 cells, and the resulting c

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Fu, Jia, Jie Zhan, Qun Chao Fan, Hui Dong Li, Zhi Xiang Fan, and Yong Gen Xu. "Regularized vibrational energies prediction and potential energy function study for some interhalogen diatomic molecules." Journal of Theoretical and Computational Chemistry 16, no. 06 (2017): 1750047. http://dx.doi.org/10.1142/s021963361750047x.

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Full vibrational energies and corresponding analytical potential energy functions (APEFs) for [Formula: see text] of ClF, [Formula: see text] of ICl, [Formula: see text] of IBr, and [Formula: see text]of IF are obtained by four-term variational algebraic energy-consistent method [VAECM(4)]. Three major methods are used to handle the regularization problems and make the results more reliable: (1) physical constraints like progressive dissociation behavior are used to overcome overfitting problems; (2) reasonable variational method is used to expand the experimental dataset and make the model op

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Uly Aldini and Wara Pramesti. "Pengelompokan Provinsi Di Indonesia Berdasarkan Indikator Mutu Pendidikan Sekolah Menengah Pertama Tahun 2016 – 2018 Menggunakan Model Based Clustering." J Statistika: Jurnal Ilmiah Teori dan Aplikasi Statistika 13, no. 2 (2020): 25–38. http://dx.doi.org/10.36456/jstat.vol13.no2.a2905.

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Peran pendidikan dalam suatu bangsa bertujuan untuk membentuk sumber daya manusia yang terdidik, berkompeten dan berkarakter. Standar Nasional Pendidikan (SNP) ditetapkan sebagai acuan pengukuran mutu pendidikan di Indonesia, dengan melihat delapan aspek yaitu Standar Pendidikan dan Tenaga Kependidikan, Standar Sarana dan Prasarana, Standar Pengelolaan, Standar Pembiayaan Pendidikan, Standar Isi, Standar Proses, Standar Penilaian Pendidikan dan Standar Kompetensi Lulusan. Penelitian sebelumnya mengenai faktor dominan yang membentuk mutu pendidikan jenjang sekolah dasar dan menengah, menjelaska

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Rozenova, Krasimira, Jing Jiang, Chao Wu, et al. "Dual Role Of MERIT40 In Hematopoietic Stem and Progenitor Cells." Blood 122, no. 21 (2013): 797. http://dx.doi.org/10.1182/blood.v122.21.797.797.

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Abstract The balance between self-renewal and differentiation of hematopoietic stem cells (HSCs) is maintained by cell intrinsic and extrinsic mechanisms, including tight regulation of signaling pathways such as Tpo-Mpl and SCF-ckit. Posttranslational modifications, such as phosphorylation and ubiquitination, regulate these pathways. While the role of protein phosphorylation is well established, the importance of ubiquitination in HSC self-renewal has not been well addressed. It is known that of the seven different lysines on ubiquitin, Lys48 polyubiquitination is a marker for protein degradat

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Nedeltchev, Gueno G., Tirumalai R. Raghunand, Mandeep S. Jassal, Shichun Lun, Qi-Jian Cheng, and William R. Bishai. "Extrapulmonary Dissemination of Mycobacterium bovis but Not Mycobacterium tuberculosis in a Bronchoscopic Rabbit Model of Cavitary Tuberculosis." Infection and Immunity 77, no. 2 (2008): 598–603. http://dx.doi.org/10.1128/iai.01132-08.

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ABSTRACT The rabbit model of tuberculosis is attractive because of its pathophysiologic resemblance to the disease in humans. Rabbits are naturally resistant to infection but may manifest cavitary lung lesions. We describe here a novel approach that utilizes presensitization and bronchoscopic inoculation to reliably produce cavities in the rabbit model. With a fixed inoculum of bacilli, we were able to reproducibly generate cavities by using Mycobacterium bovis Ravenel, M. bovis AF2122, M. bovis BCG, M. tuberculosis H37Rv, M. tuberculosis CDC1551, and the M. tuberculosis CDC1551 ΔsigC mutant.

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Saiz-Lopez, A., and C. S. Boxe. "A mechanism for biologically-induced iodine emissions from sea-ice." Atmospheric Chemistry and Physics Discussions 8, no. 1 (2008): 2953–76. http://dx.doi.org/10.5194/acpd-8-2953-2008.

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Abstract. Only recently, ground- and satellite-based measurements have reported high concentrations of IO in coastal Antarctica. The sources of such a large iodine burden in the Antarctic atmosphere remain unknown. We propose a novel mechanism for iodine release from sea-ice surfaces. The release is triggered by the biological production of iodide (I-) and hypoiodous acid (HOI) from marine algae, contained within and underneath sea-ice, and their diffusion through sea-ice brine channels to accumulate in the quasi-liquid layer on the surface of sea-ice. A multiphase chemical model of polar atmo

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Yao, Xuyang, Mingjun Zhang, Yu Zhang, Hanyu Xiao, and Jiaxin Wang. "Research on Evaluation of Climate Comfort in Northwest China under Climate Change." Sustainability 13, no. 18 (2021): 10111. http://dx.doi.org/10.3390/su131810111.

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Based on the monthly observation data of major surface meteorological observatories in Northwest China from 1960 to 2019, this paper uses the temperature and humidity index (THI), wind efficiency index (WEI), and clothing index (ICL) to construct a comprehensive climate comfort index evaluation model. This model was used to quantitatively evaluate the change characteristics of climate comfort in Northwest China against the background of climate warming. The results show that the overall climate comfort index in Northwest China is on the rise. In terms of space, an increase in the climate comfo

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Wood, John C., Maya Otto-Duessel, Michelle Aguilar, Hanspeter Nick, Thomas D. Coates, and Moats Rex. "Dose Response of Deferoxamine, Deferiprone, and ICL670 Chelation Therapy in a Gerbil Model of Iron Overload." Blood 104, no. 11 (2004): 3621. http://dx.doi.org/10.1182/blood.v104.11.3621.3621.

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Abstract Introduction: The Mongolian gerbil mimics many of the cardiac functional impairments observed in iron cardiomyopathy, however relatively few chelation studies have been performed in this model. The purpose of this study was to characterize the dose-response of deferoxamine, ICL670, and deferiprone (L1) with respect to liver and cardiac iron chelation in the gerbil Methods: Thirty three adult Mongolian gerbils underwent subcutaneous iron dextran loading with 1500 mg/kg iron dextran divided into three, weekly doses. Chelation began at 4 weeks and continued for 4 weeks. Animals were divi

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Rego, Meghan A., Frederick W. Kolling, Elizabeth A. Vuono, Maurizio Mauro, and Niall G. Howlett. "Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein." Blood 120, no. 10 (2012): 2109–17. http://dx.doi.org/10.1182/blood-2012-02-410472.

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Abstract The Fanconi anemia (FA)–BRCA pathway is critical for the repair of DNA interstrand crosslinks (ICLs) and the maintenance of chromosome stability. A key step in FA-BRCA pathway activation is the covalent attachment of monoubiquitin to FANCD2 and FANCI. Monoubiquitinated FANCD2 and FANCI localize in chromatin-associated nuclear foci where they interact with several well-characterized DNA repair proteins. Importantly, very little is known about the structure, function, and regulation of FANCD2. Herein, we describe the identification and characterization of a CUE (coupling of ubiquitin co

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Mullins, Elwood A., Garrett M. Warren, Noah P. Bradley, and Brandt F. Eichman. "Structure of a DNA glycosylase that unhooks interstrand cross-links." Proceedings of the National Academy of Sciences 114, no. 17 (2017): 4400–4405. http://dx.doi.org/10.1073/pnas.1703066114.

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DNA glycosylases are important editing enzymes that protect genomic stability by excising chemically modified nucleobases that alter normal DNA metabolism. These enzymes have been known only to initiate base excision repair of small adducts by extrusion from the DNA helix. However, recent reports have described both vertebrate and microbial DNA glycosylases capable of unhooking highly toxic interstrand cross-links (ICLs) and bulky minor groove adducts normally recognized by Fanconi anemia and nucleotide excision repair machinery, although the mechanisms of these activities are unknown. Here we

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Salim, Kamilah Radin, Morina Abdullah, Habibah Norehan Haron, Noor Hamizah Hussain, and Ruzana Ishak. "A Team-Teaching Model in an Informal Cooperative Learning Classroom." International Journal of Emerging Technologies in Learning (iJET) 14, no. 20 (2019): 44. http://dx.doi.org/10.3991/ijet.v14i20.11458.

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Research has indicated that informal cooperative learning (ICL) can make the environment in a classroom more conducive for teaching and learning. Through ICL, students could focus their attention on the material taught in class and help each other in the learning process. However, implementing ICL may require more time and effort from the lecturers because they need to prepare teaching materials and different tasks for class activities. Some-times it may be difficult for the lecturer to monitor all students in the groups when implementing ICL. Thus, this study aimed to explore the im-plementat

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Yi, Y. B., C. W. Wang, and A. M. Sastry. "Compression of Packed Particulate Systems: Simulations and Experiments in Graphitic Li-ion Anodes." Journal of Engineering Materials and Technology 128, no. 1 (2005): 73–80. http://dx.doi.org/10.1115/1.2130733.

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Increased thermal conductivity, electronic conductivity, and reversible capacity (i.e., reduced irreversible capacity loss, or ICL) have been demonstrably achievable by compression of anodes into higher volume fraction plates, though excessive compression can impair Li-ion battery performance. In our previous study, we correlated conductivity and compression of these materials. Here, we further investigated the effects of friction and deformability of particles on the compressibility of model carbons of Li-ion anodes. First, we implemented a statistically unbiased technique for generating a ra

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Houiji, Imen, Mounira Mahdouani, Mahfoudh Raïssi, and Ramzi Bourguiga. "Modeling and optimization of organic tandem photovoltaic solar cells using silver nanowires as electrode and interconnecting layer." European Physical Journal Applied Physics 93, no. 2 (2021): 20202. http://dx.doi.org/10.1051/epjap/2021200354.

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Much research has been conducted to improve the performance of photovoltaic solar cells. Transparent conductive film and interconnection layers have a significant impact on the performance of photovoltaic cells. In this work, we analyze the experimental results obtained on tandem organic photovoltaic solar cells with simple inverted structures using silver nanowires AgNW as transparent conductive electrode (TE) and as interconnection layer (ICL) between PEDOT: PSS and ZnO. This type of contact leads to a strong ohmic contact in both sub-cells having P3HT: ICBA as the lower active layer and hav

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Phillips, Matthew R., Hagen Telg, Sergei O. Kucheyev, Olaf Gelhausen, and Milos Toth. "Cathodoluminescence Efficiency Dependence on Excitation Density in n-Type Gallium Nitride." Microscopy and Microanalysis 9, no. 2 (2003): 144–51. http://dx.doi.org/10.1017/s1431927603030204.

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Cathodoluminescence (CL) spectra from silicon doped and undoped wurtzite n-type GaN have been measured in a SEM under a wide range of electron beam excitation conditions, which include accelerating voltage, beam current, magnification, beam diameter, and specimen temperature. The CL intensity dependence on excitation density was analyzed using a power-law model (ICL ∝ Jm) for each of the observed CL bands in this material. The yellow luminescence band present in both silicon and undoped GaN exhibits a close to cube root (m = 0.33) dependence on electron beam excitation at both 77 K and 300 K.

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Jung, Moonjung, Sunandini Sridhar, Audrey Goldfarb, et al. "A Novel Source of Endogenous DNA Damage That Requires Repair By the Fanconi Anemia Pathway." Blood 134, Supplement_1 (2019): 106. http://dx.doi.org/10.1182/blood-2019-127686.

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Fanconi anemia (FA) is the most common inherited bone marrow failure (BMF) syndrome. Impaired DNA interstrand crosslink (ICL) repair is the underlying mechanism for BMF in FA. FA patients usually develop BMF during the first decade of life, prior to any known exposure to exogenous crosslinking agents. Therefore, endogenous sources of DNA damage are most likely to play an important role in the pathogenesis of FA. Metabolic by-products, such as reactive aldehydes, have been implicated in the acceleration of BMF or leukemia in both humans and mice lacking the ICL repair pathway. However, the pote

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