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Journal articles on the topic 'ICSI timings'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

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1

Maggiulli, Roberta, Danilo Cimadomo, Gemma Fabozzi, et al. "The effect of ICSI-related procedural timings and operators on the outcome." Human Reproduction 35, no. 1 (2020): 32–43. http://dx.doi.org/10.1093/humrep/dez234.

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Abstract STUDY QUESTION Do the ICSI-related procedural timings and operators affect the outcomes of an ART cycle? SUMMARY ANSWER The ICSI-related timings and operators do not associate with the mean blastulation rate per cohort of inseminated oocytes and the cumulative delivery rate per concluded cycle, except for a mild association between the times from induction of ovulation to oocyte denudation and the former outcome. WHAT IS KNOWN ALREADY In ART, specific timings, protocols and conditions must be complied with to preserve gamete developmental and reproductive competence during the require
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Yovich, John L. "The effect of ICSI-related procedural timings and operators on the outcome." GSC Biological and Pharmaceutical Sciences 11, no. 1 (2020): 009–11. https://doi.org/10.5281/zenodo.4276848.

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A recent publication from a private IVF facility in Rome reports surprising findings in respect to ICSI-related procedural timings. The GENERA group reported on ICSI outcomes with fresh autologous oocytes where the insemination process was conducted with fresh non-donor ejaculated sperm. With primary outcome being the cumulative delivery rate (CDR) and secondary outcome the mean blastulation rate, the group showed that the latter was significantly higher when oocyte denudation for ICSI was performed less than 38 hours from ovulation induction rather than their usual 38-42 hours. Furthermore, t
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Patrat, Catherine, Aida Kaffel, Lucie Delaroche, et al. "Optimal Timing for Oocyte Denudation and Intracytoplasmic Sperm Injection." Obstetrics and Gynecology International 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/403531.

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Objectives. To analyze the impact of oocyte denudation and microinjection timings on intracytoplasmic sperm injection (ICSI) outcomes.Study Design. We included ICSI cycles with the following parameters: rank 1 or 2, female age years, male factor infertility, long protocol using GnRH agonist and rFSH for ovarian stimulation, and use of freshly ejaculated sperm (). Several ICSI parameters were analyzed according to the time between oocyte retrieval and denudation () and the time between denudation and ICSI () using a statistical logistic regression analysis.Results. Neither nor had a significant
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Yovich John L. "The effect of ICSI-related procedural timings and operators on the outcome." GSC Biological and Pharmaceutical Sciences 11, no. 1 (2020): 009–11. http://dx.doi.org/10.30574/gscbps.2020.11.1.0075.

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Carvalho, M., F. Leal, S. Mota, et al. "The effect of denudation and injection timing in the reproductive outcomes of ICSI cycles: new insights into the risk of in vitro oocyte ageing." Human Reproduction 35, no. 10 (2020): 2226–36. http://dx.doi.org/10.1093/humrep/deaa211.

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Abstract STUDY QUESTION Does the time elapsed between oocyte pick-up (OPU) and denudation or injection affect the probability of achieving a live birth (LB) in ICSI cycles? SUMMARY ANSWER Prolonged oocyte culture before denudation (>4 h) was associated with an increase in clinical pregnancy (CP), LB and cumulative LB (CLB) rates when compared with earlier denudation timings. WHAT IS KNOWN ALREADY Oocyte maturation is a complex and dynamic process involving structural and biochemical modifications in the cell necessary to support fertilization and early embryo development. While meiotic
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Sayed, Shabana, Bjørn Molt Petersen, Marte Myhre Reigstad, Arne Schwennicke, Jon Wegner Hausken, and Ritsa Storeng. "Predicting IVF live -birth probability using time-lapse data: Implications of including or excluding age in a day 2 embryo transfer model." PLOS ONE 20, no. 2 (2025): e0318480. https://doi.org/10.1371/journal.pone.0318480.

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The primary objective of this study was to develop predictive models for the likelihood of live births following In Vitro Fertilisation (IVF) treatment, based on a retrospective analysis of time-lapse data from Day 2 embryo transfers at Klinikk Hausken, Norway. This analysis encompassed 1,506 IVF treatment cycles, which included 865 single and 641 double embryo transfer cycles, totalling 2,147 embryos transferred. The model covariates included nucleation error, timing of two-cell stage (t2) and duration between t2 and the three-cell stage (t3). The predictive ability was assessed using Area Un
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Casanovas, Aida, Jordi Ribas-Maynou, Sandra Lara-Cerrillo, et al. "Double-stranded sperm DNA damage is a cause of delay in embryo development and can impair implantation rates." Fertility and Sterility 111, no. 4 (2019): 699–707. https://doi.org/10.1016/j.fertnstert.2018.11.035.

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Objective: To analyze the effect of single and double stranded sperm DNA fragmentation (ssSDF and dsSDF) on human embryo kinetics monitored under time-lapse system. Design: Observational, double blind, prospective cohort study. Setting: University, University spin-off and private center. Patients: 196 embryos from 43 infertile couples included prospectively. Interventions: None Main outcome Measures: ssSDF and dsSDF were analyzed in the same semen sample used for ICSI. Embryo kinetics was then monitored using time-lapse technology, obtaining timings of each embryo division. Results When compar
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Canesin, H. S., J. G. Brom-de-Luna, Y. H. Choi, A. M. Pereira, G. G. Macedo, and K. Hinrichs. "51 Effect of Cryoprotectant Exposure Time on Development of Vitrified-Warmed Immature Equine Oocytes." Reproduction, Fertility and Development 30, no. 1 (2018): 164. http://dx.doi.org/10.1071/rdv30n1ab51.

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Effective methods for cryopreservation of equine oocytes have not yet been established. Vitrification involves use of high cryoprotectant (CPA) concentrations, which can be cytotoxic. Thus, it is critical to determine a CPA concentration and exposure time able to protect the cell during cooling but with a minimal toxicity. Using a rapid non-equilibrating system, we fixed the time in the first, lower CPA concentration solution (V1) at 40 s, based on the time to maximal shrinkage. We then evaluated different exposure times in the final vitrification solution (V2). Cumulus-oocyte complexes (COC)
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Magarey, Genevieve M., and Karen E. Mate. "Timing and ultrastructure of events following intracytoplasmic sperm injection in a marsupial, the tammar wallaby (Macropus eugenii)." Reproduction, Fertility and Development 15, no. 7 (2003): 397. http://dx.doi.org/10.1071/rd03033.

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The aim of the present study was to determine the timing of oocyte activation, sperm decondensation and pronucleus formation after intracytoplasmic sperm injection (ICSI) in the tammar wallaby and to determine the fate of sperm structures at an ultrastructural level. Metaphase II-stage tammar wallaby oocytes were injected with spermatozoa and cultured for 1 (n = 15), 2 (n = 24), 4 (n = 30), 6 (n = 14), 8 (n = 32), 10 (n = 25), 12 (n = 29) or 19 h (n = 12). Oocytes were assessed using light, fluorescence and electron microscopy. The timing of oocyte activation and sperm decondensation after ICS
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O’Neill, C. L., S. Chow, Z. Rosenwaks, and G. D. Palermo. "Development of ICSI." Reproduction 156, no. 1 (2018): F51—F58. http://dx.doi.org/10.1530/rep-18-0011.

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The first conception outside of the human body that led to the birth of Louise Brown was a tremendous accomplishment, which opened the door to the utilization of assisted reproductive techniques globally. This brought the understanding that accomplishing life in a dish required several steps, the most obvious being the timing and characteristics of fertilization. It soon became obvious in the 1980s that the most disappointing phenomenon was unexpected and complete fertilization failure. Among the approaches that were attempted to treat male factor infertility, ICSI surfaced as the technique th
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Tepla, Olga, Zinovij Topurko, Simona Jirsova, et al. "Timing of ICSI with Respect to Meiotic Spindle Status." International Journal of Molecular Sciences 24, no. 1 (2022): 105. http://dx.doi.org/10.3390/ijms24010105.

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The aim of this study was to evaluate the efficiency of using meiotic spindle (MS) visibility and relative position to the polar body (PB) as indicators of oocyte maturation in order to optimize intracytoplasmic sperm injection (ICSI) timing. This was a cohort study of patients younger than 40 years with planned ICSI, the timing of which was determined by MS status, compared with those without MS evaluation. The angle between PB and MS and MS visibility were evaluated by optical microscope with polarizing filter. Oocytes with MS evaluation were fertilized according to MS status either 5–6 h af
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Yildiz, K., A. Akinci, B. Yalçin, U. Uçar, and F. Burak. "Evaluation of benefits of oocyte denudation timing at ICSI." Fertility and Sterility 90 (September 2008): S348—S349. http://dx.doi.org/10.1016/j.fertnstert.2008.07.1542.

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13

Cohen, Y. "Spindle imaging: a new marker for optimal timing of ICSI?" Human Reproduction 19, no. 3 (2004): 649–54. http://dx.doi.org/10.1093/humrep/deh113.

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14

Inge, Megan, Hanna McLennan, Shauna Heinrich, et al. "#77 : A Micro 3D Printed Device for Intracytoplasmic Sperm Injection Removes the Requirement for a Holding Pipette and Reduces Complexity of the Procedure." Fertility & Reproduction 05, no. 04 (2023): 316. http://dx.doi.org/10.1142/s2661318223741280.

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Background and Aims: One of the most skilled procedures performed by embryologists is intracytoplasmic sperm injection (ICSI), which takes significant experience to master. Conducting the procedure requires a high level of concentration with training a significant burden on clinical laboratory efficiency. Advancement of a micro 3D printed device to hold oocytes has removed the requirement for a holding pipette, reducing the complexity of the ICSI procedure. This study shows that the microICSIÔ device reduces the technical difficulty of ICSI, improving the speed and precision of the procedure.
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Shebl, Omar, Philip Sebastian Trautner, Sabine Enengl, et al. "Ionophore application for artificial oocyte activation and its potential effect on morphokinetics: a sibling oocyte study." Journal of Assisted Reproduction and Genetics 38, no. 12 (2021): 3125–33. http://dx.doi.org/10.1007/s10815-021-02338-3.

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Abstract Purpose To evaluate whether ionophore application at the oocyte stage changes the morphokinetics of the associated embryos in cases of artificial oocyte activation. Methods In a prospective sibling oocyte approach, 78 ICSI patients with suspected fertilization problems had half of their MII-oocytes treated with a ready-to-use ionophore (calcimycin) immediately following ICSI (study group). Untreated ICSI eggs served as the control group. Primary analyses focused on morphokinetic behavior and the presence of irregular cleavages. The rates of fertilization, utilization, pregnancy, and l
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Ahmed Badawy , Ahmed El-Zayadi, Abdelhady Zayed ,. Yasser Mesbah,. "Timing of endometrial scratching for women undergoing ICSI: A randomized clinical trial." Egyptian Journal of Fertility of Sterility 24, no. 2 (2020): 2–10. http://dx.doi.org/10.21608/egyfs.2020.105463.

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Maserati, Marc P., Marcos A. Gonçalves, Ana Claudia T. Oliviera, Thiago AR Oliveira, José Henrique F. Pontes, and Perla DC Fleury. "Effect of pre-maturation oocyte timing on equine ICSI embryo development rates." Journal of Equine Veterinary Science 125 (June 2023): 104663. http://dx.doi.org/10.1016/j.jevs.2023.104663.

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18

Ng, Lily, Philip Xie, Stephanie Cheung, Peter N. Schlegel, Zev Rosenwaks, and Gianpiero D. Palermo. "TIMING OF MICRO-TESE IN NOA PATIENT DOES NOT AFFECT ICSI CLINICAL OUTCOME." Fertility and Sterility 120, no. 4 (2023): e203-e204. http://dx.doi.org/10.1016/j.fertnstert.2023.08.586.

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19

Tjong, Michael C., Malavan Ragulojan, Ian Poon, et al. "Safety Related to the Timing of Radiotherapy and Immune Checkpoint Inhibitors in Patients with Advanced Non-Small Cell Lung Cancer: A Single Institutional Experience." Current Oncology 29, no. 1 (2022): 221–30. http://dx.doi.org/10.3390/curroncol29010021.

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Background: The safety impact of radiotherapy (RT) timing relative to immune checkpoint inhibitors (ICIs) for advanced non-small-cell lung cancer (NSCLC) is unclear. We investigated if RT within 14 days (Interval 1) and 90 days (Interval 2) of ICI use is associated with toxicities compared to RT outside these intervals. Methods: Advanced NSCLC patients treated with both RT and ICIs were reviewed. Toxicities were graded as per CTCAE v4.0 and attributed to either ICIs or RT by clinicians. Associations between RT timing and Grade ≥2 toxicities were analyzed using logistic regression models adjust
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Nikita, Nikita, Joshua Banks, Scott W. Keith, et al. "Is Timing of Steroid Exposure Prior to Immune Checkpoint Inhibitor Initiation Associated with Treatment Outcomes in Melanoma? A Population-Based Study." Cancers 14, no. 5 (2022): 1296. http://dx.doi.org/10.3390/cancers14051296.

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Immune checkpoint inhibitors (ICIs) harness the immune system and are the therapy of choice for multiple cancers. Although immunosuppressive agents such as steroids are also used in many cancers, it is unknown how their timing affects treatment outcomes. Thus, we investigated the relationship between the timing of steroid exposure preceding ICI administration and subsequent treatment outcomes in melanoma. This population-based study utilized the SEER-Medicare-linked database to identify patients diagnosed with melanoma between 1991 and 2015 and receiving ICIs between 2010 and 2016, examining l
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Vaios, Eugene, Rachel Shenker, Peter Hendrickson, et al. "RADT-15. INTRACRANIAL OUTCOMES OF DUAL IMMUNE-CHECKPOINT INHIBITION AND SRS COMBINATION IN PATIENTS WITH MELANOMA AND NSCLC BRAIN METASTASES." Neuro-Oncology 25, Supplement_5 (2023): v51. http://dx.doi.org/10.1093/neuonc/noad179.0204.

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Abstract INTRODUCTION The intracranial benefit of offering dual immune checkpoint inhibition (D-ICPI) with ipilimumab and nivolumab to melanoma and non-small cell lung cancer (NSCLC) patients receiving SRS for brain metastases is unknown. We hypothesized that D-ICPI improves local control compared to SRS alone. METHODS Melanoma and NSCLC patients treated with SRS between 2016-2022 were evaluated. Patients were stratified by treatment with D-ICPI, single ICPI (S-ICPI), or SRS alone. Local recurrence (LR), intracranial progression (IP), and overall survival (OS) were estimated using competing ri
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Azizi, Elham, Mohammad Naji, Hamid Nazarian, et al. "Does timing in ICSI cycle affect oocyte quality and reproductive outcomes? A prospective study." Archives of Gynecology and Obstetrics 302, no. 2 (2020): 505–13. http://dx.doi.org/10.1007/s00404-020-05555-w.

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Hickman, C. F. L., A. Campbell, and S. Fishel. "Optimising the timing between oocyte collection, cumulus removal and insemination by ICSI or IVF." Fertility and Sterility 96, no. 3 (2011): S79. http://dx.doi.org/10.1016/j.fertnstert.2011.07.305.

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Gonçalves, Lisa, Duarte Goncalves, Teresa Esteban Casanelles, et al. "Retro TIMing: A multicentric retrospective analysis of immunotherapy timing in metastatic melanoma." Journal of Clinical Oncology 42, no. 16_suppl (2024): 9542. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.9542.

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9542 Background: Immune checkpoint inhibitors (ICI) targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) are now the standard of care in the treatment of metastatic melanoma (mM). The interplay between cancer cells and tumor microenvironment cells (e.g. immune cells) impacts cancer cell survival, local invasion, and metastatic dissemination. Chrono-immunotherapy is an emerging field as circadian oscillations are observed in the immune landscape (e.g immune cell numbers) as well as in the expression of immunotherapy targets (e.g. PD-1). Recen
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Dozortsev, D., T. Wakaiama, A. Ermilov, and R. Yanagimachi. "Intracytoplasmic sperm injection in the rat." Zygote 6, no. 2 (1998): 143–47. http://dx.doi.org/10.1017/s0967199498000069.

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We applied intracytoplasmic sperm injection (ICSI) to the rat comparing three different sperm injection techniques: conventional setup with a sharp needle bearing a spike (method 1), combination of partial zona dissection (PZD) needle and blunt pipette (method 2) and piezo-injection using a blunt pipette (method 3). We also investigated the timing of sperm pronuclear formation after injection. Survival rates after injection were 8%, 24% and 71% for the methods 1, 2 and 3, respectively. All surviving oocytes formed pronuclei by about 6 h after injection. Although the survival and activation rat
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Cook, H., G. Ambartsumyan, Y. Mahller, M. Pisarska, C. Briton-Jones, and D. Hill. "The effect of intracytoplasmic sperm injection (ICSI) on the timing of embryonic progression in cycles where oocytes were split into both ICSI and conventional insemination." Fertility and Sterility 98, no. 3 (2012): S158. http://dx.doi.org/10.1016/j.fertnstert.2012.07.584.

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Hyun, C. S., J. H. Cha, W. Y. Son, S. H. Yoon, K. A. Kim, and J. H. Lim. "Optimal ICSI timing after the first polar body extrusion in in vitro matured human oocytes." Human Reproduction 22, no. 7 (2007): 1991–95. http://dx.doi.org/10.1093/humrep/dem124.

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Abdelrahim, Maen, Abdullah Esmail, Mukul K. Divatia, et al. "Utilization of Immunotherapy as a Neoadjuvant Therapy for Liver Transplant Recipients with Hepatocellular Carcinoma." Journal of Clinical Medicine 13, no. 11 (2024): 3068. http://dx.doi.org/10.3390/jcm13113068.

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Background: Hepatocellular carcinoma (HCC) is widely recognized as the predominant type of primary liver malignancy. Orthotopic liver transplantation (OLT) has emerged as a highly effective treatment option for unresectable HCC. Immunotherapies as neoadjuvant options are now being actively investigated in the transplant oncology era to enhance outcomes in patients with HCC. Here, we report our experience with patients with HCC who had received Immune Checkpoint Inhibitors (ICPI) prior to curative OLT. Methods: This was a retrospective cohort that included patients with HCC who received ICPI pr
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Mochtar, M. H., I. M. Custers, C. A. M. Koks, et al. "Timing oocyte collection in GnRH agonists down-regulated IVF and ICSI cycles: a randomized clinical trial." Human Reproduction 26, no. 5 (2011): 1091–96. http://dx.doi.org/10.1093/humrep/der048.

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Azizi, Elham, Mohammad Naji, Hamid Nazarian, et al. "Correction to: Does timing in ICSI cycle affect oocyte quality and reproductive outcomes? A prospective study." Archives of Gynecology and Obstetrics 302, no. 2 (2020): 515–18. http://dx.doi.org/10.1007/s00404-020-05613-3.

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MANAL O. EL-HAMSHARY, NEVINE A. TAWAB. "Could Artificial Oocyte Electro -Activation Timing Affect the Fertilization Rate in Post-Intracytoplasmic Sperm Injection (ICSI)?" Medical Journal of Cairo University 91, no. 09 (2023): 1197–203. http://dx.doi.org/10.21608/mjcu.2023.326239.

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Shiraiwa, Yuki, Noritoshi Enatsu, Kazuki Yamagami, et al. "Clinical Outcomes of Rescue Intracytoplasmic Sperm Injection at Different Timings Following In Vitro Fertilization." Journal of Reproduction & Infertility, November 1, 2021. http://dx.doi.org/10.18502/jri.v22i4.7650.

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Background: Although rescue intracytoplasmic sperm injection (r-ICSI) is extensively used worldwide, the indication of r-ICSI and its optimal timing remains obscure. This study aimed to assess the outcomes of r-ICSI following in vitro fertilization in different timings when fertilization is confirmed.
 Methods: This study included 5,156 cycles (47,785 eggs). Fertilization was confirmed by polar body analysis after 4 and 6 hr of coincubation of the sperm and oocyte. Oocytes that underwent IVF were divided into two groups based on the time when a second polar body was detected in more than
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Gupta, I., M. Thorrowgood, K. Ashton, V. Chapple, and Y. Liu. "P-203 Searching for the optimal timing of intracytoplasmic sperm injection post oocyte retrieval: a systematic review and meta-analysis." Human Reproduction 37, Supplement_1 (2022). http://dx.doi.org/10.1093/humrep/deac107.196.

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Abstract Study question What is the optimal time post oocyte retrieval (POR) to undertake intracytoplasmic sperm injection (ICSI) in order to maximise subsequent pregnancy and live birth outcomes? Summary answer Delaying ICSI for 5 hours or more POR may compromise subsequent clinical pregnancy and live birth rates. What is known already It is often challenging to perform ICSI at a set timing POR, especially in ART clinics with a heavy workload. However, the degree of flexibility in ICSI timing remains unclear in the literature. Some articles have reported detrimental impacts by delaying ICSI o
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Shi, Cheng, Ping Wang, Rong Liang, et al. "Optimal ICSI timing on immature oocytes for low prognosis patients under the POSEIDON classification." BMC Pregnancy and Childbirth 24, no. 1 (2024). http://dx.doi.org/10.1186/s12884-024-06577-x.

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Abstract Background The optimal timing of performing ICSI on immature oocytes for POSEIDON patients is still unknown to get better early embryonic development outcomes. The purpose of this study was to implore the most appropriate time to carry out ICSI on in vitro maturation GV and MI oocytes for POSEIDON patients. Methods Two hundred thirty-nine immature oocytes from 163 POSEIDON patients were prospectively performed ICSI at different timings: P-ICSI (ICSI was performed on in vitro matured oocytes 4–6 h after the first polar body extrusion, N = 81), R-ICSI (ICSI was performed on in vitro mat
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Gupta, Isha, Mathilda Thorrowgood, Kevin J. Ashton, Evelyne Rathbone, Vincent Chapple, and Yanhe Liu. "The Timing of Intracytoplasmic Sperm Injection Relative to Oocyte Retrieval: A Systematic Review and Meta-Analysis." Fertility & Reproduction, November 30, 2022, 1–7. http://dx.doi.org/10.1142/s2661318223300027.

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Background: It is currently inconclusive whether different intracytoplasmic sperm injection (ICSI) timings post oocyte retrieval (POR) lead to altered chance of clinical pregnancy and live birth following in vitro fertilization (IVF) treatment. This study, therefore, aimed to synthesize literature-based evidence for better clinical guidance regarding ICSI practice. Methods: A systematic review and meta-analysis were performed according to PRISMA guidelines. Studies were searched for in PubMed, MEDLINE, EMBASE, and the Cochrane Library. Outcome endpoints included clinical pregnancy and live bir
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Chapple, N., K. Bickendorf, K. Peirce, V. Chapple, J. Natalwala, and Y. Liu. "P-270 The timing of intracytoplasmic sperm injection does not impact live birth rate and neonatal outcomes." Human Reproduction 38, Supplement_1 (2023). http://dx.doi.org/10.1093/humrep/dead093.628.

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Abstract Study question Does the timing of intracytoplasmic sperm injection (ICSI) relative to ovulation trigger impact live birth rates and neonatal outcomes? Summary answer ICSI timing relative to ovulation trigger impacts neither live birth rates nor neonatal outcomes. What is known already When conducting ICSI, the timing of the insemination relative to ovulation trigger is difficult to standardise in clinical practice, especially in busy ART laboratories. Flexibility when scheduling ICSI procedures would therefore be beneficial from a laboratory management perspective. However, the impact
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Oron, G., I. Blais, M. Koifman, et al. "P-240 Embryo division timings and morphikinetic top-quality embryo rates derived from GnRH-antagonist ICIS cycles triggered by either hCG, GnRH-agonist or Dual trigger." Human Reproduction 37, Supplement_1 (2022). http://dx.doi.org/10.1093/humrep/deac107.230.

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Abstract Study question To compare the division timings and morphikinetic top-quality embryo rates derived from GnRH-antagonist ICSI cycles triggered with either hCG, GnRH-agonist or Dual trigger. Summary answer GnRH-agonist trigger derived embryos had significantly shorter division timing durations and a higher top-quality cleavage embryo rates compared to the other trigger groups What is known already TMS allows embryo quality assessment by documenting timing of events and length of intervals in embryo development, providing a more objective scoring of the embryos for embryo selection. Devel
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Aizer, Adva, Meirav Noach‐Hirsh, Chen Shimon, et al. "Impact of artificial oocyte activation with calcium ionophore on ICSI outcomes using surgically retrieved spermatozoa: A comprehensive analysis." Andrology, April 25, 2025. https://doi.org/10.1111/andr.70047.

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AbstractBackgroundIntracytoplasmic sperm injection (ICSI) is an effective technique for addressing male infertility. However, fertilization challenges persist, particularly with spermatozoa obtained through testicular sperm procedures.ObjectivesThis study evaluates the impact of artificial oocyte activation (AOA) on ICSI outcomes using surgically retrieved spermatozoa (motile, immotile, fresh, and frozen), including results from vitrified‐warmed embryo transfers and investigating potential improvements in clinical outcomes.Materials and MethodsA retrospective analysis was conducted on 73 testi
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Montjean, D., C. Pacios, G. Hamiche, M. H. Godin-Pagé, M. Benkhalifa, and P. Miron. "P-108 Automated sperm selection software (SiD) provides similar results as human selection for ICSI." Human Reproduction 39, Supplement_1 (2024). http://dx.doi.org/10.1093/humrep/deae108.482.

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Abstract Study question Automated sperm selection or human eye-based sperm selection, does it make a difference on IVF lab outcomes and clinical outcomes? Summary answer Single sperm selection by the AI SiD was as proficient as highly experienced embryologists and embryo development may have improved for inexperienced embryologists What is known already The implementation of artificial intelligence in reproductive medicine has proven effective for a variety of applications. One application for this technology is single sperm selection during ICSI. The computer assisted program SiD, was designe
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Makieva, Sofia, Celine Stähli, Min Xie, Ana Velasco Gil, Maike Katja Sachs, and Brigitte Leeners. "The impact of zygote vitrification timing on pregnancy rate in frozen-thawed IVF/ICSI cycles." Frontiers in Cell and Developmental Biology 11 (January 13, 2023). http://dx.doi.org/10.3389/fcell.2023.1095069.

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Introduction: Cryopreservation of bipronuclear (2PN) stage zygotes is an integral part of IVF laboratory practice in countries with strict embryo culture legislation. Vitrification of zygotes is compatible with several strategies in infertility treatments holding a freeze-all indication and allows for effective workload management in settings with limited resources. Although it yields high survival rates and clinical outcomes, the ideal timing to commence vitrification of zygotes is elusive while it is empirically practiced in the window between 17 and 21 h post-insemination (hpi). We aimed to
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Montjean, D., M. H. Godin-Pagé, M. Benkhalifa, and P. Miron. "P-312 Automated sperm selection software (SiD) is as good as human selection for ICSI." Human Reproduction 38, Supplement_1 (2023). http://dx.doi.org/10.1093/humrep/dead093.670.

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Abstract Study question Automated sperm selection or human eye-based sperm selection, does it make a difference on IVF lab outcomes? Summary answer Single sperm selection by the AI SiD was as proficient as highly experienced embryologists and embryo development may have improved for inexperienced embryologists. What is known already The implementation of artificial intelligence in reproductive medicine has proven effective for a variety of applications. One application for this technology is single sperm selection during ICSI. The computer assisted program SiD, was designed to grade sperm, in
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Koifman, M., I. Blais, S. Lahav-Baratz, et al. "P-062 Morphokinetic embryo division timings and top-quality cleavage and blastocyst rates are unaffected by sperm quality." Human Reproduction 37, Supplement_1 (2022). http://dx.doi.org/10.1093/humrep/deac107.058.

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Abstract Study question Does testicular extracted sperm affect embryo morphokinetics and the rate of top-quality cleavage and blastocyst embryos. Summary answer Sperm origin, whether ejaculated normal sperm or testicular extracted sperm, was not found to affect embryo morphokinetic timings or top-quality embryo rates. What is known already Time-lapse monitoring (TLM) allows for continuous observation of the developing embryo detecting continuous embryo morphologic and kinetic changes from the zygote to the blastocyst stage. It eliminates potential unnecessary environmental fluctuations and dim
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Kugelman, Nir, Wisam Assaf, Idit Blais, et al. "Embryo division timings and top-quality embryo rates in GnRH-Antagonist ICSI cycles: a comparison of hCG and dual trigger methods." Journal of Assisted Reproduction and Genetics, July 22, 2025. https://doi.org/10.1007/s10815-025-03601-7.

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Blais, I., M. Koifman, S. Lahav-Baratz, G. Younes, Z. Weiner-Megnazi, and G. Oron. "P-209 Overweight and obese women have slower developing embryos and a lower rate of morphokinetic top-quality blastocysts compared to underweight and normal weight women." Human Reproduction 37, Supplement_1 (2022). http://dx.doi.org/10.1093/humrep/deac107.202.

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Abstract Study question Does maternal body mass index affect embryo morphokinetics and the rate of top-quality blastocysts Summary answer Overweight and obese women had slower developing embryos and a lower rate of top-quality blastocysts compared to underweight and normal weight women What is known already Time-lapse monitoring (TLM) allows for a detailed collection of embryo morphologic and kinetic changes compared to traditional periodic daily assessments. TLM allows for continuous observation of the developing embryo in time intervals for dynamic assessment of embryo morphokinetics. This m
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Scarica, C., F. Barbarulo, E. Pontemezzo, et al. "P-287 Characterization of novel blastocyst development parameters using Time-Lapse Imaging: insights into embryo hyperactivity and its putative impact on embryo selection." Human Reproduction 40, Supplement_1 (2025). https://doi.org/10.1093/humrep/deaf097.595.

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Abstract Study question Can novel Time-Lapse imaging behaviour, such as embryo hyperactivity, provide valuable insights for improving embryo selection and predicting blastocyst developmental outcomes? Summary answer Embryo hyperactivity (HE) does not compromise the in-vitro development to the blastocyst stage, and is not correlated with direct cleavage, nor morphokinetic parameters timings. What is known already Embryonic hyperactivity is a novel but underexplored phenomenon observed through Time-Lapse Imaging. Unlike extensively studied morphokinetic events like multinucleation and direct cle
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Cermisoni, G. C., F. Innocenti, M. Taggi, et al. "P-046 Ejaculatory abstinence: is there any association with embryo developmental competence? A Retrospective Study in time-lapse incubators." Human Reproduction 39, Supplement_1 (2024). http://dx.doi.org/10.1093/humrep/deae108.423.

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Abstract Study question Is ejaculatory abstinence (EA) associated with fertilization and blastocyst development in ICSI cycles with embryo culture in time-lapse incubators? Summary answer There is no association between length of EA and fertilization, blastocyst development or morphology. What is known already Semen analysis is pivotal in medically assisted reproduction (MAR), serving as a significant indicator of male partners’ health. The period of EA is a relevant factor that can affect sperm quality. Numerous studies described EA association with clinical outcomes, while its impact on embr
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Trio, S., F. Innocenti, G. Saturno, et al. "P-297 Comprehensive artificial intelligence-powered investigation of blastocyst expansion dynamics: associations with competence." Human Reproduction 38, Supplement_1 (2023). http://dx.doi.org/10.1093/humrep/dead093.655.

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Abstract Study question Are blastocyst expansion dynamics from time of starting blastulation (tSB) to time of biopsy (t-biopsy) indicative of embryo competence? Summary answer Early expansion dynamics across 5hours after tB, embryo-proper area (emb-A), zona-pellucida-area (zp-A), ZP-thickness (zp-T) at t-biopsy and their t-biopsy/tB ratios are associated with competence. What is known already Blastocyst expansion is the very first morphogenetic event common to several species. Time-lapse-technology (TLT) implementation in IVF allowed deeper understanding of blastocyst expansion process. Some s
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Liu, Y., J. Natalwala, and V. Chapple. "P-090 Alignment amongst zygotic cleavage plane, pronuclear axis and polar axis as a biomarker for blastocyst viability." Human Reproduction 40, Supplement_1 (2025). https://doi.org/10.1093/humrep/deaf097.399.

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Abstract Study question Is alignment amongst zygotic cleavage plane, pronuclear axis and polar axis associated with live birth outcome of single freshly transferred blastocyst? Summary answer Alignment amongst zygotic cleavage plane, pronuclear axis and polar axis is associated with higher live birth potential following fresh blastocyst transfer. What is known already Morphology-based blastocyst selection prior to intrauterine transfer remains a challenge in IVF. In a recent study, a lower euploidy rate was noted in ICSI-derived blastocysts demonstrating a perpendicular zygotic cleavage plane
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Marteil, Gaëlle, Aïcha Metchat, Sandra Dollet, et al. "Vitrification of Human Oocytes Before or After Rescue-IVM Does not Impair Maturation Kinetics but Induces Meiotic Spindle Alterations." Reproductive Sciences, May 21, 2024. http://dx.doi.org/10.1007/s43032-024-01596-7.

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AbstractCryopreservation of in vitro matured oocytes is still considered as an experimental alternative to mature oocyte vitrification after ovarian stimulation. Here, we investigated whether rescue-IVM should be performed before or after vitrification. For this, 101 immature oocytes (germinal vesicle stage) from women undergoing ICSI were used. Oocytes were divided into three groups: freshly in vitro matured oocytes (IVM), freshly in vitro matured oocytes subsequently vitrified (IVM + VIT) and vitrified/warmed GV oocytes then in vitro matured (VIT + IVM). Oocyte maturation rates and kinetics
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Esbert, M., N. Kubikova, J. Fagan, et al. "P-287 Morphokinetic analysis of early embryos subjected to double stranded DNA damage provides evidence for cell cycle checkpoint activity." Human Reproduction 38, Supplement_1 (2023). http://dx.doi.org/10.1093/humrep/dead093.645.

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Abstract Study question Is there evidence of cell cycle checkpoint activation in preimplantation embryos with double stranded breaks (DSBs) in their DNA, induced using CRISPR? Summary answer Cells with persistent double strand DNA damage exhibit longer timeframes to reach key morphological milestones than those with successful repair, consistent with checkpoint activation. What is known already In most cell types, DNA damage leads to activation of cell cycle checkpoints that halt the cycle while DNA repair is attempted. It has been hypothesised that early embryos lack (or have relaxed) checkpo
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