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Journal articles on the topic 'IDRs'

Author: Grafiati

Published: 25 May 2024

Last updated: 25 July 2025

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1

Han, Bingqing, Chongjiao Ren, Wenda Wang, Jiashan Li, and Xinqi Gong. "Computational Prediction of Protein Intrinsically Disordered Region Related Interactions and Functions." Genes 14, no. 2 (2023): 432. http://dx.doi.org/10.3390/genes14020432.

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Intrinsically Disordered Proteins (IDPs) and Regions (IDRs) exist widely. Although without well-defined structures, they participate in many important biological processes. In addition, they are also widely related to human diseases and have become potential targets in drug discovery. However, there is a big gap between the experimental annotations related to IDPs/IDRs and their actual number. In recent decades, the computational methods related to IDPs/IDRs have been developed vigorously, including predicting IDPs/IDRs, the binding modes of IDPs/IDRs, the binding sites of IDPs/IDRs, and the m

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2

Coskuner-Weber, Orkid, and Vladimir N. Uversky. "Current Stage and Future Perspectives for Homology Modeling, Molecular Dynamics Simulations, Machine Learning with Molecular Dynamics, and Quantum Computing for Intrinsically Disordered Proteins and Proteins with Intrinsically Disordered Regions." Current Protein & Peptide Science 25, no. 2 (2024): 163–71. http://dx.doi.org/10.2174/0113892037281184231123111223.

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Abstract:: The structural ensembles of intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) cannot be easily characterized using conventional experimental techniques. Computational techniques complement experiments and provide useful insights into the structural ensembles of IDPs and proteins with IDRs. Herein, we discuss computational techniques such as homology modeling, molecular dynamics simulations, machine learning with molecular dynamics, and quantum computing that can be applied to the studies of IDPs and hybrid proteins with IDRs. We also

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3

Liu, Meili, Akshaya K. Das, James Lincoff, et al. "Configurational Entropy of Folded Proteins and Its Importance for Intrinsically Disordered Proteins." International Journal of Molecular Sciences 22, no. 7 (2021): 3420. http://dx.doi.org/10.3390/ijms22073420.

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Many pairwise additive force fields are in active use for intrinsically disordered proteins (IDPs) and regions (IDRs), some of which modify energetic terms to improve the description of IDPs/IDRs but are largely in disagreement with solution experiments for the disordered states. This work considers a new direction—the connection to configurational entropy—and how it might change the nature of our understanding of protein force field development to equally well encompass globular proteins, IDRs/IDPs, and disorder-to-order transitions. We have evaluated representative pairwise and many-body pro

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4

Ahmed, Shehab S., Zaara T. Rifat, Ruchi Lohia, et al. "Characterization of intrinsically disordered regions in proteins informed by human genetic diversity." PLOS Computational Biology 18, no. 3 (2022): e1009911. http://dx.doi.org/10.1371/journal.pcbi.1009911.

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All proteomes contain both proteins and polypeptide segments that don’t form a defined three-dimensional structure yet are biologically active—called intrinsically disordered proteins and regions (IDPs and IDRs). Most of these IDPs/IDRs lack useful functional annotation limiting our understanding of their importance for organism fitness. Here we characterized IDRs using protein sequence annotations of functional sites and regions available in the UniProt knowledgebase (“UniProt features”: active site, ligand-binding pocket, regions mediating protein-protein interactions, etc.). By measuring th

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Medvedev, Kirill E., Jimin Pei, and Nick V. Grishin. "DisEnrich: database of enriched regions in human dark proteome." Bioinformatics 38, no. 7 (2022): 1870–76. http://dx.doi.org/10.1093/bioinformatics/btac051.

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Abstract Motivation Intrinsically disordered proteins (IDPs) are involved in numerous processes crucial for living organisms. Bias in amino acid composition of these proteins determines their unique biophysical and functional features. Distinct intrinsically disordered regions (IDRs) with compositional bias play different important roles in various biological processes. IDRs enriched in particular amino acids in human proteome have not been described consistently. Results We developed DisEnrich—the database of human proteome IDRs that are significantly enriched in particular amino acids. Each

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6

Felli, Isabella C., Wolfgang Bermel, and Roberta Pierattelli. "Exclusively heteronuclear NMR experiments for the investigation of intrinsically disordered proteins: focusing on proline residues." Magnetic Resonance 2, no. 1 (2021): 511–22. http://dx.doi.org/10.5194/mr-2-511-2021.

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Abstract. NMR represents a key spectroscopic technique that contributes to the emerging field of highly flexible, intrinsically disordered proteins (IDPs) or protein regions (IDRs) that lack a stable three-dimensional structure. A set of exclusively heteronuclear NMR experiments tailored for proline residues, highly abundant in IDPs/IDRs, are presented here. They provide a valuable complement to the widely used approach based on amide proton detection, filling the gap introduced by the lack of amide protons in proline residues within polypeptide chains. The novel experiments have very interest

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7

Saito, Akatsuki, Maya Shofa, Hirotaka Ode, et al. "How Do Flaviviruses Hijack Host Cell Functions by Phase Separation?" Viruses 13, no. 8 (2021): 1479. http://dx.doi.org/10.3390/v13081479.

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Viral proteins interact with different sets of host cell components throughout the viral life cycle and are known to localize to the intracellular membraneless organelles (MLOs) of the host cell, where formation/dissolution is regulated by phase separation of intrinsically disordered proteins and regions (IDPs/IDRs). Viral proteins are rich in IDRs, implying that viruses utilize IDRs to regulate phase separation of the host cell organelles and augment replication by commandeering the functions of the organelles and/or sneaking into the organelles to evade the host immune response. This review

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8

Kastano, Kristina, Gábor Erdős, Pablo Mier, et al. "Evolutionary Study of Disorder in Protein Sequences." Biomolecules 10, no. 10 (2020): 1413. http://dx.doi.org/10.3390/biom10101413.

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Intrinsically disordered proteins (IDPs) contain regions lacking intrinsic globular structure (intrinsically disordered regions, IDRs). IDPs are present across the tree of life, with great variability of IDR type and frequency even between closely related taxa. To investigate the function of IDRs, we evaluated and compared the distribution of disorder content in 10,695 reference proteomes, confirming its high variability and finding certain correlation along the Euteleostomi (bony vertebrates) lineage to number of cell types. We used the comparison of orthologs to study the function of disorde

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9

Alshehri, Manal A., Manee M. Manee, Mohamed B. Al-Fageeh, and Badr M. Al-Shomrani. "Genomic Analysis of Intrinsically Disordered Proteins in the Genus Camelus." International Journal of Molecular Sciences 21, no. 11 (2020): 4010. http://dx.doi.org/10.3390/ijms21114010.

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Intrinsically disordered proteins/regions (IDPs/IDRs) fail to fold completely into 3D structures, but have major roles in determining protein function. While natively disordered proteins/regions have been found to fulfill a wide variety of primary cellular roles, the functions of many disordered proteins in numerous species remain to be uncovered. Here, we perform the first large-scale study of IDPs/IDRs in the genus Camelus, one of the most important mammalians in Asia and North Africa, in order to explore the biological roles of these proteins. The study includes the prediction of disordered

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10

Chiang, Wan-Chin, Ming-Hsuan Lee, Tsai-Chen Chen, and Jie-rong Huang. "Interactions between the Intrinsically Disordered Regions of hnRNP-A2 and TDP-43 Accelerate TDP-43′s Conformational Transition." International Journal of Molecular Sciences 21, no. 16 (2020): 5930. http://dx.doi.org/10.3390/ijms21165930.

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Most biological functions involve protein–protein interactions. Our understanding of these interactions is based mainly on those of structured proteins, because encounters between intrinsically disordered proteins (IDPs) or proteins with intrinsically disordered regions (IDRs) are much less studied, regardless of the fact that more than half eukaryotic proteins contain IDRs. RNA-binding proteins (RBPs) are a large family whose members almost all have IDRs in addition to RNA binding domains. These IDRs, having low sequence similarity, interact, but structural details on these interactions are s

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11

Gill, Michelle L., R. Andrew Byrd, and Arthur G. Palmer, III. "Dynamics of GCN4 facilitate DNA interaction: a model-free analysis of an intrinsically disordered region." Physical Chemistry Chemical Physics 18, no. 8 (2016): 5839–49. http://dx.doi.org/10.1039/c5cp06197k.

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12

McFadden, William M., and Judith L. Yanowitz. "idpr: A package for profiling and analyzing Intrinsically Disordered Proteins in R." PLOS ONE 17, no. 4 (2022): e0266929. http://dx.doi.org/10.1371/journal.pone.0266929.

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Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are proteins or protein-domains that do not have a single native structure, rather, they are a class of flexible peptides that can rapidly adopt multiple conformations. IDPs are quite abundant, and their dynamic characteristics provide unique advantages for various biological processes. The field of “unstructured biology” has emerged, in part, because of numerous computational studies that had identified the unique characteristics of IDPs and IDRs. The package ‘idpr’, short for Intrinsically Disordered Protein

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13

Goswami, Achintya Mohan. "In silico prediction of the intrinsic disorder and ligand binding sites of human 3β-hydroxysteroid dehydrogenase type 2 enzyme". Research Journal of Biotechnology 20, № 2 (2024): 140–46. https://doi.org/10.25303/202rjbt1400146.

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In human, the 3β-hydroxysteroid dehydrogenase (HSD3B)/Δ4,5-isomerase is an important enzyme in steroid hormone biosynthesis. It catalyzed the conversion of Δ5-steroid precursors to respective Δ4-ketosteroids. There were two HSD3B isoenzymes designated as type 1(HSD3B1) and type 2 (HSD3B2), encoded by two different genes located in chromosome 1p13.1. The mutations in HSD3B2 gene could lead to congenital adrenal hyperplasia and impaired steroidogenesis in both the adrenals and gonads leading to varieties of phenotypes. It was known that many proteins had intrinsically disordered regions (IDRs) a

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14

Fujiwara, Satoru. "Dynamical Behavior of Disordered Regions in Disease-Related Proteins Revealed by Quasielastic Neutron Scattering." Medicina 58, no. 6 (2022): 795. http://dx.doi.org/10.3390/medicina58060795.

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Background and Objectives: Intrinsically disordered proteins (IDPs) and proteins containing intrinsically disordered regions (IDRs) are known to be involved in various human diseases. Since the IDPs/IDRs are fluctuating between many structural substrates, the dynamical behavior of the disease-related IDPs/IDRs needs to be characterized to elucidate the mechanisms of the pathogenesis of the diseases. As protein motions have a hierarchy ranging from local side-chain motions, through segmental motions of loops or disordered regions, to diffusive motions of entire molecules, segmental motions, as

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15

Kastano, Kristina, Pablo Mier, Zsuzsanna Dosztányi, Vasilis J. Promponas, and Miguel A. Andrade-Navarro. "Functional Tuning of Intrinsically Disordered Regions in Human Proteins by Composition Bias." Biomolecules 12, no. 10 (2022): 1486. http://dx.doi.org/10.3390/biom12101486.

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Intrinsically disordered regions (IDRs) in protein sequences are flexible, have low structural constraints and as a result have faster rates of evolution. This lack of evolutionary conservation greatly limits the use of sequence homology for the classification and functional assessment of IDRs, as opposed to globular domains. The study of IDRs requires other properties for their classification and functional prediction. While composition bias is not a necessary property of IDRs, compositionally biased regions (CBRs) have been noted as frequent part of IDRs. We hypothesized that to characterize

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16

Brocca, Stefania, Rita Grandori, Sonia Longhi, and Vladimir Uversky. "Liquid–Liquid Phase Separation by Intrinsically Disordered Protein Regions of Viruses: Roles in Viral Life Cycle and Control of Virus–Host Interactions." International Journal of Molecular Sciences 21, no. 23 (2020): 9045. http://dx.doi.org/10.3390/ijms21239045.

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Intrinsically disordered proteins (IDPs) are unable to adopt a unique 3D structure under physiological conditions and thus exist as highly dynamic conformational ensembles. IDPs are ubiquitous and widely spread in the protein realm. In the last decade, compelling experimental evidence has been gathered, pointing to the ability of IDPs and intrinsically disordered regions (IDRs) to undergo liquid–liquid phase separation (LLPS), a phenomenon driving the formation of membrane-less organelles (MLOs). These biological condensates play a critical role in the spatio-temporal organization of the cell,

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17

Tarantino, Adriana, Giuseppe Ciconte, Andrea Ghiroldi, et al. "Challenges in Brugada Syndrome Stratification: Investigating SCN5A Mutation Localization and Clinical Phenotypes." International Journal of Molecular Sciences 24, no. 23 (2023): 16658. http://dx.doi.org/10.3390/ijms242316658.

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Brugada Syndrome (BrS) is a genetic heart condition linked to sudden cardiac death. Though the SCN5A gene is primarily associated with BrS, there is a lack of comprehensive studies exploring the connection between SCN5A mutation locations and the clinical presentations of the syndrome. This study aimed to address this gap and gain further understanding of the syndrome. The investigation classified 36 high-risk BrS patients based on SCN5A mutations within the transmembrane/structured (TD) and intra-domain loops (IDLs) lacking a 3D structure. We characterized the intrinsically disordered regions

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18

Gonçalves-Kulik, Mariane, Pablo Mier, Kristina Kastano, et al. "Low Complexity Induces Structure in Protein Regions Predicted as Intrinsically Disordered." Biomolecules 12, no. 8 (2022): 1098. http://dx.doi.org/10.3390/biom12081098.

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There is increasing evidence that many intrinsically disordered regions (IDRs) in proteins play key functional roles through interactions with other proteins or nucleic acids. These interactions often exhibit a context-dependent structural behavior. We hypothesize that low complexity regions (LCRs), often found within IDRs, could have a role in inducing local structure in IDRs. To test this, we predicted IDRs in the human proteome and analyzed their structures or those of homologous sequences in the Protein Data Bank (PDB). We then identified two types of simple LCRs within IDRs: regions with

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Pintado-Grima, Carlos, Oriol Bárcenas, and Salvador Ventura. "In-Silico Analysis of pH-Dependent Liquid-Liquid Phase Separation in Intrinsically Disordered Proteins." Biomolecules 12, no. 7 (2022): 974. http://dx.doi.org/10.3390/biom12070974.

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Intrinsically disordered proteins (IDPs) are essential players in the assembly of biomolecular condensates during liquid–liquid phase separation (LLPS). Disordered regions (IDRs) are significantly exposed to the solvent and, therefore, highly influenced by fluctuations in the microenvironment. Extrinsic factors, such as pH, modify the solubility and disorder state of IDPs, which in turn may impact the formation of liquid condensates. However, little attention has been paid to how the solution pH influences LLPS, despite knowing that this process is context-dependent. Here, we have conducted a

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20

Watson, Matthew, and Katherine Stott. "Disordered domains in chromatin-binding proteins." Essays in Biochemistry 63, no. 1 (2019): 147–56. http://dx.doi.org/10.1042/ebc20180068.

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Abstract Chromatin comprises proteins, DNA and RNA, and its function is to condense and package the genome in a way that allows the necessary transactions such as transcription, replication and repair to occur in a highly organised and regulated manner. The packaging of chromatin is often thought of in a hierarchical fashion starting from the most basic unit of DNA packaging, the nucleosome, to the condensation of nucleosomal ‘beads on a string’ by linker histones to form the 30-nm fibre and eventually large chromatin domains. However, a picture of a more heterogeneous, dynamic and liquid-like

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21

Uversky, Vladimir N. "On the Roles of Protein Intrinsic Disorder in the Origin of Life and Evolution." Life 14, no. 10 (2024): 1307. http://dx.doi.org/10.3390/life14101307.

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Obviously, the discussion of different factors that could have contributed to the origin of life and evolution is clear speculation, since there is no way of checking the validity of most of the related hypotheses in practice, as the corresponding events not only already happened, but took place in a very distant past. However, there are a few undisputable facts that are present at the moment, such as the existence of a wide variety of living forms and the abundant presence of intrinsically disordered proteins (IDPs) or hybrid proteins containing ordered domains and intrinsically disordered re

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Jain, Mayank, Vinod Kumar, Manish Jain, Kapil Garg, Ravi Shekhawat, and Pankaj Kumar Gupta. "Indian Diabetes Risk Score (IDRS) as a strong predictor of diabetes mellitus: A cross sectional study among urban population of Jhalawar, Rajasthan." Indian Journal of Community Health 34, no. 1 (2022): 60–66. http://dx.doi.org/10.47203/ijch.2022.v34i01.012.

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Introduction: The patients with Type 2 diabetes Mellitus may often remain asymptomatic for a longer period of time. The Indian Diabetes Risk Score (IDRS), a simple screening tool for prediction of undiagnosed diabetes. Objective: Validation of IDRS with standard test for type 2 diabetes among urban population of Jhalawar, Rajasthan. Material and Methods: A Community based Cross-sectional study was carried out in urban field practice area of Department of Community Medicine, Jhalawar Medical College, Jhalawar, Rajasthan. The study was conducted using a two-stage sampling design. A predesigned,

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Kharoliwal, Chirag, Disha Mangal, Surabhi Chakraborty, and Shweta Mangal. "Estimation of Diabetes Risk Among Medical Students in Rajasthan Using Indian Diabetes Risk Score (IDRS)." Medical Journal of Dr. D.Y. Patil Vidyapeeth 18, no. 2 (2025): 205–9. https://doi.org/10.4103/mjdrdypu.mjdrdypu_218_24.

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ABSTRACT Introduction: Diabetes is the leading cause of mortality with over 19% of the world’s diabetic population being Indians. Medical college students have sedentary lifestyles and are predisposed to developing diabetes at a younger age. Hence, the present study was formulated to estimate the risk of developing diabetes using the IDRS scoring and anthropometric determinants such as BMI and waist-hip ratio among medical students in Rajasthan. Materials and Methods: The present cross-sectional study was conducted among 256 medical students in Jaipur. Demographic data, questions pertaining to

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Pritišanac, Iva, Robert Vernon, Alan Moses, and Julie Forman Kay. "Entropy and Information within Intrinsically Disordered Protein Regions." Entropy 21, no. 7 (2019): 662. http://dx.doi.org/10.3390/e21070662.

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Bioinformatics and biophysical studies of intrinsically disordered proteins and regions (IDRs) note the high entropy at individual sequence positions and in conformations sampled in solution. This prevents application of the canonical sequence-structure-function paradigm to IDRs and motivates the development of new methods to extract information from IDR sequences. We argue that the information in IDR sequences cannot be fully revealed through positional conservation, which largely measures stable structural contacts and interaction motifs. Instead, considerations of evolutionary conservation

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Singhal, Raghav, and Anil Kapoor. "Validity Assessment of IDRS for Diabetes Mellitus." PJSR 10, no. 2 (2017): 49–52. https://doi.org/10.5281/zenodo.8242836.

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A cross sectional study was conducted in a tertiary health care centre of Central India to determine correlation between IDRS and fasting blood sugar to assess the validity of IDRS in diagnosing DM. In the diabetic group, high risk, medium risk and low risk were found to be 85(42.5%), 105(52.5%) and 10 (5%) respectively as per IDRS criteria, whereas 54(13.5%), 187(46.8%) and 159(39.8%) cases for the same categories were apparently healthy subjects. IDRS was correlated with FBS ; FBS level above 126 mg% (undiagnosed or hidden diabetics) was found among 12(3%) in high risk to medium risk individ

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Vovk, Andrei, and Anton Zilman. "Effects of Sequence Composition, Patterning and Hydrodynamics on the Conformation and Dynamics of Intrinsically Disordered Proteins." International Journal of Molecular Sciences 24, no. 2 (2023): 1444. http://dx.doi.org/10.3390/ijms24021444.

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Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) perform diverse functions in cellular organization, transport and signaling. Unlike the well-defined structures of the classical natively folded proteins, IDPs and IDRs dynamically span large conformational and structural ensembles. This dynamic disorder impedes the study of the relationship between the amino acid sequences of the IDPs and their spatial structures and dynamics, with different experimental techniques often offering seemingly contradictory results. Although experimental and theoretical evidence

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Singleton, Marc D., and Michael B. Eisen. "Evolutionary analyses of intrinsically disordered regions reveal widespread signals of conservation." PLOS Computational Biology 20, no. 4 (2024): e1012028. http://dx.doi.org/10.1371/journal.pcbi.1012028.

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Intrinsically disordered regions (IDRs) are segments of proteins without stable three-dimensional structures. As this flexibility allows them to interact with diverse binding partners, IDRs play key roles in cell signaling and gene expression. Despite the prevalence and importance of IDRs in eukaryotic proteomes and various biological processes, associating them with specific molecular functions remains a significant challenge due to their high rates of sequence evolution. However, by comparing the observed values of various IDR-associated properties against those generated under a simulated m

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Gupta, Manoj Kumar, Gitashree Dutta, Sridevi G., et al. "Application of Indian Diabetic Risk Score (IDRS) and Community Based Assessment Checklist (CBAC) as Metabolic Syndrome prediction tools." PLOS ONE 18, no. 3 (2023): e0283263. http://dx.doi.org/10.1371/journal.pone.0283263.

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Background Indian Diabetic Risk Score (IDRS) and Community Based Assessment Checklist (CBAC) are easy, inexpensive, and non-invasive tools that can be used to screen people for Metabolic Syndrome (Met S). The study aimed to explore the prediction abilities of IDRS and CBAC tools for Met S. Methods All the people of age ≥30 years attending the selected rural health centers were screened for Met S. We used the International Diabetes Federation (IDF) criteria to diagnose the Met S. ROC curves were plotted by taking Met S as dependent variables, and IDRS and CBAC scores as independent/prediction v

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Zhao, Bi, and Lukasz Kurgan. "Compositional Bias of Intrinsically Disordered Proteins and Regions and Their Predictions." Biomolecules 12, no. 7 (2022): 888. http://dx.doi.org/10.3390/biom12070888.

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Intrinsically disordered regions (IDRs) carry out many cellular functions and vary in length and placement in protein sequences. This diversity leads to variations in the underlying compositional biases, which were demonstrated for the short vs. long IDRs. We analyze compositional biases across four classes of disorder: fully disordered proteins; short IDRs; long IDRs; and binding IDRs. We identify three distinct biases: for the fully disordered proteins, the short IDRs and the long and binding IDRs combined. We also investigate compositional bias for putative disorder produced by leading diso

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Homma, Keiichi, Hiroto Anbo, Tamotsu Noguchi, and Satoshi Fukuchi. "Both Intrinsically Disordered Regions and Structural Domains Evolve Rapidly in Immune-Related Mammalian Proteins." International Journal of Molecular Sciences 19, no. 12 (2018): 3860. http://dx.doi.org/10.3390/ijms19123860.

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Eukaryotic proteins consist of structural domains (SDs) and intrinsically disordered regions (IDRs), i.e., regions that by themselves do not assume unique three-dimensional structures. IDRs are generally subject to less constraint and evolve more rapidly than SDs. Proteins with a lower number of protein-to-protein interactions (PPIs) are also less constrained and tend to evolve fast. Extracellular proteins of mammals, especially immune-related extracellular proteins, on average have relatively high evolution rates. This article aims to examine if a high evolution rate in IDRs or that in SDs ac

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Sharma, Kanupriya, Priya Battu, Akshay Anand, et al. "Management of Type II Diabetes by Modulating the Modifiable Risk Factors: A Future Roadmap for Prevention of Cerebrovascular Complications." Annals of Neurosciences 27, no. 3-4 (2020): 266–72. http://dx.doi.org/10.1177/09727531211000041.

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Background: Indian Diabetes Risk Score (IDRS) is a screening tool for quantifying the risk of diabetes mellitus (DM) development in the Indian population. The present study has evaluated the level of risk of developing DM in Chandigarh and Panchkula based on the IDRS score. Methods: As a part of a national diabetes control trial funded by the Ministry of Health and Family Welfare (MoHFW) and the Ministry of AYUSH, Government of India, 1,916 participants from the Chandigarh and Panchkula regions were assessed for the risk of developing DM. Risk assessment was done on the basis of the IDRS score

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Namdev, Garima, and Vinod Narkhede. "A study on validity of Indian Diabetes Risk Score for screening of diabetes mellitus among rural adult population at Rural Health Training Centre, Bhouri, under Department of Community Medicine." International Journal Of Community Medicine And Public Health 5, no. 12 (2018): 5295. http://dx.doi.org/10.18203/2394-6040.ijcmph20184806.

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Background: Diabetes mellitus is a major public health problem in India and many of them remain undetected throughout years. This scenario becomes worse in rural setup where limited heath care facilities are available. So, to detect risk of diabetes earlier, Indian diabetes risk score (IDRS) is to be used. There is also various socio demographic and anthropometric factors associated with the risk of occurring diabetes. The aims and objectives of the study were to study the validity of IDRS method as a screening tool in community as well as to determine the association of IDRS with socio demogr

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M., Sumana, Hanamantappa Kudachi, and M. Sundar. "Prediction of risk of development of type 2 diabetes mellitus using Indian diabetic risk score in rural areas of Hassan." International Journal Of Community Medicine And Public Health 5, no. 3 (2018): 948. http://dx.doi.org/10.18203/2394-6040.ijcmph20180443.

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Background: It has been estimated by International Diabetic Federation (IDF) that globally as many as 193million people with diabetes, are unaware of their disease, the use of a simple easy to use, non-invasive and cost effective screening tool for community based screening is the need of the hour. This study was taken with objective to assess the risk of development of type 2 diabetes mellitus using Indian diabetic risk score (IDRS), and to determine the association of IDRS with socio-demographic factors.Methods: Cross sectional study was conducted for 3 months in rural areas of Hassan. 480 s

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Shashikantha SK, Sheethal MP, and Chandana S. "Diabetes risk assessment with Indian Diabetes Risk Score: A cross-sectional study among adults in rural Mandya, Karnataka." Asian Journal of Medical Sciences 15, no. 3 (2024): 103–7. http://dx.doi.org/10.3126/ajms.v15i3.59238.

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Background: Screening for diabetes using the Indian Diabetes Risk Score (IDRS) is an inexpensive yet effective way of early diagnosis. Aims and Objectives: The present study was conducted to assess the risk of developing diabetes among individuals in rural field practice areas using IDRS. Materials and Methods: A community-based observational study was conducted among persons aged 20 years and older in the rural field practice area for 2 months. A semi-structured interview schedule, including the “IDRS” questionnaire, was used to obtain the data. Results: Out of 1100 subjects, around 50% were

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Guarna, Marta, Haiyan Yang, Natalie Glavas, et al. "IDRs as Novel Immunomodulators (B208)." Journal of Immunology 178, no. 1_Supplement (2007): LB43. http://dx.doi.org/10.4049/jimmunol.178.supp.b208.

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Abstract Inimex Innate Defence Regulators (IDRs) are novel, synthetic immunomodulatory peptides that protect against infections by selectively activating the innate immune system while regulating inflammation. The multi-faceted effects of IDRs are mediated primarily by monocytes and macrophages. These cells respond to IDRs by selectively increasing the expression of cell surface receptors, and cytokines and chemokines (MCP-1, MCP-3 and CCL-5) which trigger the recruitment and activation of immune cells to the site of the infection. In addition, IDRs control inflammation by enhancing the expres

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Piovesan, Damiano, Alexander Miguel Monzon, Federica Quaglia, and Silvio C. E. Tosatto. "Databases for intrinsically disordered proteins." Acta Crystallographica Section D Structural Biology 78, no. 2 (2022): 144–51. http://dx.doi.org/10.1107/s2059798321012109.

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Intrinsically disordered regions (IDRs) lacking a fixed three-dimensional protein structure are widespread and play a central role in cell regulation. Only a small fraction of IDRs have been functionally characterized, with heterogeneous experimental evidence that is largely buried in the literature. Predictions of IDRs are still difficult to estimate and are poorly characterized. Here, an overview of the publicly available knowledge about IDRs is reported, including manually curated resources, deposition databases and prediction repositories. The types, scopes and availability of the various

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Akter, Nazma. "Assessment of Risk Score for Developing Type 2 Diabetes Mellitus among Bangladeshi Adults Using Indian Diabetes Risk Score." Delta Medical College Journal 9, no. 1 (2024): 9–16. http://dx.doi.org/10.3329/dmcj.v9i1.71331.

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Background: Different studies support the utilization of risk-assessment scoring systems in quantifying individual’s risk for developing type 2 diabetes mellitus (T2DM). Thus, a simple risk-assessment scoring system for early screening of T2DM among Bangladeshi adults would be beneficial to identify the high-risk adults and thus taking adequate preventive measures in combating DM. Objective: The purpose of the study was to calculate the risk assessment score for developing type 2 DM among Bangladeshi adults using IDRS (Indian Diabetes Risk Score) tool and to assess the association of different

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Kumaran, K. Myl, D. R. Vedapriya, Aravind Manoharan, and A. Y. Nirupama. "Indian diabetic risk score screening of rural adults in Tamil Nadu." IHOPE Journal of Ophthalmology 2 (May 6, 2023): 31–35. http://dx.doi.org/10.25259/ihopejo_2_2023.

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Objectives: Diabetes is acknowledged as a key public health problem with the prevalence rate increasing globally and reaching epidemic proportions. It is high time that screening programs are implemented at the community level for early detection of the population, who are at risk of having diabetes mellitus. Materials and Methods: A community-based and cross-sectional study was conducted in the rural field practice area of a tertiary care hospital in Chengalpattu district, Tamil Nadu. The screening tool used to assess the risk status was the Indian diabetes risk score (IDRS) and the body mass

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Widarjono, Agus, Md Mahmudul ALAM, and Abdur Rafik. "The Dynamic Link Between Islamic and Conventional Deposit Rates in a Dual Banking System." ISRA International Journal of Islamic Finance 15, no. 1 (2023): 91–108. http://dx.doi.org/10.55188/ijif.v15i1.487.

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Purpose — This study empirically assesses the extent to which the conventional deposit rate (CDR) affects the Islamic deposit rate (IDR) in Indonesia and Malaysia within the dual banking system. Design/Methodology/Approach — This study uses non-linear autoregressive distributed lag (NARDL) and panel cointegration. Monthly data are employed, but the time period for the two countries examined is different because of data availability. The study thus covers the period 2009:M1 to 2020:M12 for Indonesia and 2000:M1 to 2020:M12 for Malaysia. Findings — The findings confirm evidence of th

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Ahmed, Mansoor, and Amrutha A. M. "Association of socio-demographic variables and risk of type 2 diabetes using Indian diabetes risk score: a cross-sectional study in urban Mysuru." International Journal Of Community Medicine And Public Health 5, no. 2 (2018): 740. http://dx.doi.org/10.18203/2394-6040.ijcmph20180260.

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Background: About 422 million people worldwide have diabetes. India has 69.2 million people living with diabetes out of a population of 1.3 billion (8.7%) as per the 2015 data. Of these, it remained undiagnosed in more than 36 million people. Early identification of at-risk individuals and appropriate lifestyle intervention would help in preventing or postponing the onset of diabetes mellitus. Present study aimed to study the association of IDRS components with socio demographic and anthropometric variables among adults in urban area of Mysore.Methods: A community-based cross sectional study w

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Bianchi, Greta, Sonia Longhi, Rita Grandori, and Stefania Brocca. "Relevance of Electrostatic Charges in Compactness, Aggregation, and Phase Separation of Intrinsically Disordered Proteins." International Journal of Molecular Sciences 21, no. 17 (2020): 6208. http://dx.doi.org/10.3390/ijms21176208.

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The abundance of intrinsic disorder in the protein realm and its role in a variety of physiological and pathological cellular events have strengthened the interest of the scientific community in understanding the structural and dynamical properties of intrinsically disordered proteins (IDPs) and regions (IDRs). Attempts at rationalizing the general principles underlying both conformational properties and transitions of IDPs/IDRs must consider the abundance of charged residues (Asp, Glu, Lys, and Arg) that typifies these proteins, rendering them assimilable to polyampholytes or polyelectrolytes

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Avramov, Miloš, Éva Schád, Ágnes Révész, et al. "Identification of Intrinsically Disordered Proteins and Regions in a Non-Model Insect Species Ostrinia nubilalis (Hbn.)." Biomolecules 12, no. 4 (2022): 592. http://dx.doi.org/10.3390/biom12040592.

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Research in previous decades has shown that intrinsically disordered proteins (IDPs) and regions in proteins (IDRs) are as ubiquitous as highly ordered proteins. Despite this, research on IDPs and IDRs still has many gaps left to fill. Here, we present an approach that combines wet lab methods with bioinformatics tools to identify and analyze intrinsically disordered proteins in a non-model insect species that is cold-hardy. Due to their known resilience to the effects of extreme temperatures, these proteins likely play important roles in this insect’s adaptive mechanisms to sub-zero temperatu

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Hsu, Ian S., Bob Strome, Emma Lash, Nicole Robbins, Leah E. Cowen, and Alan M. Moses. "A functionally divergent intrinsically disordered region underlying the conservation of stochastic signaling." PLOS Genetics 17, no. 9 (2021): e1009629. http://dx.doi.org/10.1371/journal.pgen.1009629.

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Stochastic signaling dynamics expand living cells’ information processing capabilities. An increasing number of studies report that regulators encode information in their pulsatile dynamics. The evolutionary mechanisms that lead to complex signaling dynamics remain uncharacterized, perhaps because key interactions of signaling proteins are encoded in intrinsically disordered regions (IDRs), whose evolution is difficult to analyze. Here we focused on the IDR that controls the stochastic pulsing dynamics of Crz1, a transcription factor in fungi downstream of the widely conserved calcium signalin

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Arumugam, Balaji, Aadarshna R., and Suganya E. "Neck circumference as a risk indicator for type 2 diabetes mellitus: a community based cross-sectional study." International Journal Of Community Medicine And Public Health 6, no. 11 (2019): 4624. http://dx.doi.org/10.18203/2394-6040.ijcmph20195032.

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Background: Diabetes mellitus is a metabolic syndrome due to insulin deficiency, characterized by hyperglycaemia. Indian diabetes risk score (IDRS) is the most commonly used one to determine the risk status. However there is lot of inconvenience and possible errors in measuring the waist circumference to determine the IDRS, hence the study was planned to evaluate if neck circumference could replace waist circumference in determining the diabetes risk.Methods: This cross sectional study was conducted among 300 study participants fulfilling the eligible criteria. Socio-demographic variables, par

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Bavaskar, Yogita G., Debasmita Roy, Ganesh Lokhande, et al. "Risk assessment of diabetes among undergraduate students of Northern Maharashtra using Indian Diabetes Risk Score and its correlation with fasting blood glucose." MGM Journal of Medical Sciences 11, no. 3 (2024): 460–66. http://dx.doi.org/10.4103/mgmj.mgmj_29_24.

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Abstract Background: Diabetes, once primarily associated with old age, is increasingly prevalent among young adults. The Indian Diabetes Risk Score (IDRS) employs four parameters—age, waist circumference, family history of diabetes, and physical activity—to screen for diabetes. This study aims to evaluate the risk and prevalence of diabetes and prediabetes in undergraduate medical students and to correlate these findings with their fasting glucose levels. Materials and Methods: A cross-sectional descriptive study was carried out among 336 undergraduate medical students in the Jalgaon district

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Boone, Brandon A., Cristy P. Mendoza, Noah J. Behrendt та Steven E. Jacobsen. "α-Crystalline Domains and Intrinsically Disordered Regions Can Work in Parallel to Induce Accumulation of MBD6 at Chromocenters in Arabidopsis thaliana". Epigenomes 8, № 3 (2024): 33. http://dx.doi.org/10.3390/epigenomes8030033.

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Proteins are localized and concentrated at cellular and genomic locations for specific and efficient functions. Efforts to understand protein accumulation in eukaryotic organisms have primarily focused on multivalent interactions between intrinsically disordered regions (IDRs) as mediators of protein condensation. We previously showed that α-crystalline domain (ACD) proteins 15 (ACD15) and 21 (ACD21) were required for multimerization and the accumulation of gene-silencing methyl-CpG-binding domain protein 6 (MBD6) at chromocenters in Arabidopsis thaliana. Here, we demonstrate that ACDs and IDR

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Hall, Wayne, and Louisa Degenhardt. "The Australian Illicit Drug Reporting System: Monitoring Trends in Illicit Drug Availability, Use and Drug-Related Harm in Australia 1996–2006." Contemporary Drug Problems 36, no. 3-4 (2009): 643–61. http://dx.doi.org/10.1177/009145090903600317.

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We describe trends in illicit drug use revealed by the Australian Illicit Drug Reporting System (IDRS) between 1996 and 2006. We begin by briefly outlining the rationale, development, and testing of the IDRS, which integrates information from: interviews with a sentinel population of injecting drug users (IDU); key experts in health and law enforcement; and indicators that include information on drug purity and price, plus indicators of drug-related harm, such as fatal and nonfatal overdoses. These sources of information are critically discussed at annual meetings of researchers, policy makers

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Saraswathi, S., Amita Mukhopadhyay, M. Sumana, Ipsita Debata, and Prem Sagar Panda. "Diabetes Risk Evaluation Using Indian Diabetes Risk Score among Adults of an Urban Slum in Bengaluru, Karnataka." Current Medical Issues 23, no. 1 (2025): 12–17. https://doi.org/10.4103/cmi.cmi_92_24.

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Abstract Background: Diabetes typically projects the Iceberg phenomenon, with most cases being hidden. The Indian diabetes risk score (IDRS) by the Madras diabetic research foundation is a validated and useful screening tool that identifies high-risk people in primary care settings. The study aimed to assess the risk of type 2 diabetes mellitus among adults in an urban slum in Bengaluru, Karnataka with the Indian diabetic risk score (IDRS). Methodology: A cross-sectional study was carried out in the community involving adults, aged 18 years and above, in the urban field practice area for 3 mon

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Garaizar, Adiran, Ignacio Sanchez-Burgos, Rosana Collepardo-Guevara, and Jorge R. Espinosa. "Expansion of Intrinsically Disordered Proteins Increases the Range of Stability of Liquid–Liquid Phase Separation." Molecules 25, no. 20 (2020): 4705. http://dx.doi.org/10.3390/molecules25204705.

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Proteins containing intrinsically disordered regions (IDRs) are ubiquitous within biomolecular condensates, which are liquid-like compartments within cells formed through liquid–liquid phase separation (LLPS). The sequence of amino acids of a protein encodes its phase behaviour, not only by establishing the patterning and chemical nature (e.g., hydrophobic, polar, charged) of the various binding sites that facilitate multivalent interactions, but also by dictating the protein conformational dynamics. Besides behaving as random coils, IDRs can exhibit a wide-range of structural behaviours, incl

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Jagdeep, Singh, Marmat Himani, Patel Ikraz, and Gupta Siddhant. "Prediction of type 2 diabetes mellitus risk using Indian diabetes risk score among individuals of 30 years and above in an Indian population." Bioinformation 21, no. 06 (2025): 1481–85. https://doi.org/10.6026/973206300211481.

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Indian Diabetes Risk Score (IDRS) was assessed among 2,847 adults aged 30 and above living in urban and rural areas in India. Data showed that 41.3% of participants were at high risk (IDRS ≥60) and these individuals often had obesity, a family history of the disease and a sedentary way of life. IDRS was found to be trustworthy, affordable and easy on patients. It is valuable for discovering diabetes at the earliest stage. Thus, this approach can be used in diabetes prevention programs across India.

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