Dissertations / Theses: 'IF3'

1

Qin, Daoming. "Role of 16S Ribosomal RNA in Translation Initiation." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299007063.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Garcia, Gonzalez Carlos. "Etude structurale du facteur d'initiation 3 d'Escherichia coli (IF3) par R. M. N." Palaiseau, École polytechnique, 1995. http://www.theses.fr/1995EPXX0047.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

DE, COCK EVE. "If3 d'escherichia coli. Etudes fonctionnelles et structurales de ce facteur de demarrage de la synthese des proteines." Paris 6, 1999. http://www.theses.fr/1999PA066118.

Full text

Abstract:

Le facteur de demarrage de la traduction if3 est une proteine specifique des eubacteries, essentielle a la viabilite cellulaire. Elle intervient dans la reconnaissance du codon de demarrage d'un gene par le ribosome et garantit la concentration en sous-unites 30s libres alors susceptibles d'interagir avec l'arn messager. Son role, dans la cascade d'evenements se produisant sur le complexe de demarrage de la traduction, est encore mal compris. Au cours de ce travail, nous nous sommes particulierement interesses au domaine c-terminal d'if3 qui est responsable de la fixation d'if3 sur la sous-unite 30s et au domaine de fixation de ce dernier dans l'arn 16s. Ainsi, nous avons mis en evidence que la region centrale de l'arn 16s (556-884) serait responsable de la fixation d'if3. Par rmn, nous avons observe que la face d'interaction d'if3c avec le domaine central de l'arn 16s etait constituee de l'helice 1 du brin 1 et de la boucle 130 (residus 130-139). Nous avons alors mis en evidence l'importance du residu d106 qui joue un role dans la specificite de l'interaction, cet acide amine serait un antideterminant. Pour comprendre le role d'if3 dans la fidelite du demarrage, nous avons etudie l'importance du peptide de connexion qui relie le domaine n-terminal au domaine c-terminal d'if3. Une approche combinant des etudes in vitro (biochimiques, biologie moleculaire), in vivo (tests de fonctionnalite) et structurales (rmn) a ete retenue. Nous avons montre que le domaine n-terminal ne pouvait pas assurer seul la fidelite du demarrage. Le peptide de connexion n'a, semble-t-il, pas de role a jouer dans la fonction d'if3 mais il garantit l'action concomitante des deux domaines de la proteine. La fixation des deux domaines d'if3 pourrait induire un changement de conformation dans la sous-unite 30s qui serait a l'origine de la discrimination par celle-ci des complexes ternaires de composition non canonique.

APA, Harvard, Vancouver, ISO, and other styles

4

MOINE, HERVE. "Etude de la traduction de l'arnm chez escherichia coli : role du facteur d'initiation if3 dans la formation du complexe ribosome/arnm, controle de la traduction de l'arnm: le cas de threonyl-arnt synthetase." Strasbourg 1, 1990. http://www.theses.fr/1990STR13020.

Full text

Abstract:

Deux etapes fondamentales de la synthese d'une proteine chez escherichia coli ont ete etudiees: (1) l'interaction entre le facteur d'initiation if3 et la sous-unite ribosomique 30s; (2) la regulation de la traduction d'un arn messager: l'arnm de la threonyl-arnt synthetase. Le role de if3 a ete etudie en analysant son site de fixation sur la sous-unite 30s, au moyen d'un reactif de pontage: le trans-diaminodichloro platine (ii). If3 a ete ponte majoritairement a l'arn ribosomique 16s au niveau de deux sites distincts. L'analyse de ces sites nous a permis de proposer un mecanisme d'action de if3 permettant d'expliquer son role dans la stimulation de la fixation de l'arnm sur la sous-unite 30s. Ce mecanisme est supporte par la phylogenie et par l'effet de if3 sur la conformation de l'arnr 16s. L'expression de la threonyl-arnt synthetase de e. Coli est autoregulee negativement au niveau traductionnel. La conformation de la region de l'arnm necessaire au controle et son interaction avec la synthetase ont ete analysees en utilisant des sondes de structure enzymatiques et chimiques. La synthetase interagit avec son propre arnm au niveau de deux sites: un site "mimant" le bras de l'anticodon de l'arnt et un site, localise en amont du premier, correspondant a une structure tige/boucle tres stable. Ces deux sites sont independants structuralement et fonctionnellement. Le premier site est indispensable pour le controle, le deuxieme ne l'est pas mais il le favorise. Le controle s'exerce sous la forme d'une competition entre la synthetase et le ribosome dans la reconnaissance de leurs sites respectifs sur l'arnm. L'arnt #t#h#r qui a un effet anti-represseur sur la synthese de sa propre synthetase permet ainsi d'ajuster la concentration d'enzyme a celle de trna dans la cellule. Une modelisation graphique de cette region de l'arnm est proposee

APA, Harvard, Vancouver, ISO, and other styles

5

Araújo, Weslei Silva de. "Das Escolas Técnicas Federais aos Institutos Federais: a licenciatura em Física no campus Goiânia do IFG." Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/5983.

Full text

Abstract:

Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-08-23T14:06:23Z No. of bitstreams: 2 Dissertação - Weslei Silva de Araújo - 2016.pdf: 1398500 bytes, checksum: f28b00fa1bf2094ab7d357e829733e78 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-08-23T14:07:36Z (GMT) No. of bitstreams: 2 Dissertação - Weslei Silva de Araújo - 2016.pdf: 1398500 bytes, checksum: f28b00fa1bf2094ab7d357e829733e78 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Made available in DSpace on 2016-08-23T14:07:36Z (GMT). No. of bitstreams: 2 Dissertação - Weslei Silva de Araújo - 2016.pdf: 1398500 bytes, checksum: f28b00fa1bf2094ab7d357e829733e78 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-07-25 In this paper we sought to understand how the Degree in Physics in IFG Goiânia campus is structured and what the perspective of teachers in the area, specifically in the implementation of degree in Physics, and forward the changes in the institution. The choice of this theme is due to the requirement stipulated by law 11.892 of December 29, 2008, the Federal Institutes of Education, Science and Technology, in offering undergraduate courses, especially in the areas of Science and Mathematics, despite its recognized expertise in professional education. Some research has dealt with the theme of the presence of the degrees in FIs, discussing the profile, the deployment and the challenges that they are consoli dated. However, here we seek teachers' perception of the process. Characterized as a qualitative study we used bibliographical research to survey the changes via legal documents in the institution, as well as research on the site e -MEC for recognizing the quantity of courses offered in this mode before and after the creation of the IFs. For analysis of the survey responses a nd interviews with teachers of Physical area of Goiânia the IFG campus, we used content analysis, according to Bardin (2002). It was identified as perceived by teachers who: (i) changes in the institution provided an expansion and internalization, even disorderly; (Ii) the change in the teaching profession and school mischaracterization with devaluation of technical education; (Iii) the course designed to meet the law, structure and operation in construction, has a focus on specific knowledge at the expense of teaching; (Iv) teachers work almost exclusively in the classroom, with little or no research and extension activities. These aspects lead to understand that there is still a lack of identity in I Fs after implantation of degrees and forward the changes in this institutions. Neste trabalho buscou-se compreender de que forma a Licenciatur a em Física no campus Goiânia do IFG se estrutura e qual a perspectiva dos professores da área , especificamente, na implantação da licenciatura em Física , e frente as mudanças ocorridas na instituição. A escolha deste tema se deve pela obrigatoriedade, estipulada pela lei 11.892 de 29 de dezembro de 2008, dos Institutos Federais de Educação, Ciência e Tecnologia, em ofertar cursos de licenciaturas, principalmente nas áreas de Ciências e Matemática, apesar de sua reconhecida competência na área de educação p rofissional. Algumas pesquisas têm tratado da temática sobre a presença das licenciaturas nos IFs, discutindo o perfil, a implantação e os desafios para que os mesmos sejam consolidados. No entanto, aqui buscamos a percepção dos professores sobre todo o pr ocesso. Caracterizado como um trabalho de abordagem qualitativa utilizou-se inicialmente de pesquisa bibliográfica para levantamento das alterações ocorridas via documentos legais na instituição, assim como pesquisa no site e -MEC para o reconhecimento do quantitativo de cursos ofertados nesta modalidade antes e depois da cria ção dos IFs. Para análise das respostas do questionário e das entrevistas realizadas com os professores da área de Física, do campus Goiânia do IFG, utilizou-se a Análise de Conteúdo, segundo Bardin (2002). Identificou-se, segundo a percepção dos professores que: (i) as mudanças na instituição proporciona ram uma expansão e interiorização, mesmo que desordenada ; (ii) a alteração na carreira do professor e a descaracterização da escola com desvalorização do ensino técnico; (iii) o curso criado para atender a lei, com estrutura e funcionamento em construção, possui um enfoque no conhecimento específico em detrimento do pedagógico; (iv) os professores atuam quase que exclusivamente em sala de aula, com poucas ou nenhuma atividade de pesquisa e de extensão. Estes aspectos levam a entender que há ainda uma falta de identidade nos IFs após a implantação das licenciaturas e frente as mudanças ocorridas nesta s instituições.

APA, Harvard, Vancouver, ISO, and other styles

6

El, Asmi Faten. "Rôle différentiel des isoformes de PML en réponse au trioxyde d’arsenic et dans la défense antivirale." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T102.

Full text

Abstract:

Les interférons (IFN) constituent une famille de cytokines aux propriétés antiprolifératives et antivirales. Ils activent, via la voie Jak/STAT, des gènes spécifiques dont les produits sont les médiateurs des effets biologiques des IFN. C’est le cas de PML (Promyelocytic leukemia), appelée aussi TRIM19, qui joue un rôle central dans la défense antivirale. PML appartenant à la famille des protéines Tripartite Motif (TRIM), caractérisée par la présence en N-terminal d’un motif RBCC, constitué d’un domaine RING, d’une ou de deux boites B et d’un domaine coiled-coil. PML a été identifiée dans la leucémie aiguë promyélocytaire, une pathologie causée par la translocation chromosomique t(15 ;17) qui fusionne les gènes PML et RARA, aboutissant à la synthèse d'une protéine chimère PML-RARA. Le trioxyde d'arsenic (As2O3) cible la portion PML de la protéine oncogénique, entraînant sa dégradation et la rémission complète des patients. Dans les cellules saines, les transcrits PML issus d’un gène unique génèrent par épissage alternatif 7 isoformes principales de PML, dont six sont nucléaires (PMLI à PMLVI) et une cytoplasmique (PMLVIIb). Toutes possèdent la même extrémité N-terminale mais diffèrent au niveau de leur extrémité C-terminale, conférant à chaque isoforme des fonctions spécifiques.PML est l’organisatrice d’une structure multi-protéique appelée corps nucléaires (CN), impliquée dans divers processus cellulaires tels que l’apoptose, la dégradation des protéines ou encore la défense antivirale.PML est modifiée par SUMO de façon covalente au niveau de trois sites lysines (K65, K160, K490) et de façon non covalente, via son domaine SIM (pour « SUMO Interacting Motif »). Ces modifications sont requises pour la formation de CN fonctionnels et le recrutement de protéines partenaires au sein de ceux-ci. Le but de ma thèse a été d’étudier le rôle différentiel des différentes isoformes de PML en réponse à l’As2O3 et suite à l’infection virale. Nous avons montré que le SIM de PML est nécessaire à sa dégradation en réponse à l'As2O3. Ce motif est présent dans toutes les isoformes de PML, hormis l’isoforme nucléaire PMLVI et l’isoforme cytoplasmique PMLVIIb. Le SIM de PML n’est pas requis pour sa SUMOylation et son interaction avec RNF4 (une E3 ubiquitine ligase responsable de la dégradation de PML via le protéasome). En revanche, ce motif est requis pour l’ubiquitination de PML, le recrutement des composants du protéasome et sa dégradation en réponse à l’As2O3. Concernant les propriétés antivirales de PML, l’étude que nous avons menée avec toutes les isoformes de PML a permis de montrer que seules PMLIII et PMLIV confèrent une résistance au Virus de la Stomatite Vésiculaire (VSV). L’effet antiviral de PMLIII n'est observé qu'à faible multiplicité d’infection (MOI) et est indépendant de la production d’IFN. Par contre, PMLIV exerce une puissante activité anti-VSV, y compris à forte MOI et s'exerce selon deux mécanismes distincts : (i) PMLIV inhibe la réplication du VSV par un mécanisme précoce indépendant de l’IFN, (ii) PMLIV augmente tardivement la production d’IFN-β via une plus forte activation d’IRF3 qui est due à la séquestration spécifique de Pin1 au sein des CN par PMLIV. Ces deux processus nécessitent la SUMOylation de PMLIV. Ces résultats montrent que PMLIV exerce une activité antivirale intrinsèque et est impliquée dans l’immunité innée en régulant positivement la voie de transduction conduisant à la synthèse d’IFN-β Interferons (IFNs) are a family of cytokines with antiproliferative and antiviral properties.They activate, via the Jak/Stat pathway, specific genes whose products are the mediators of the biological effects of IFNs. This is the case of PML (Promyelocytic leukemia), also known as TRIM19, which plays a central role in antiviral defense.PML belongs to the Tripartite Motif (TRIM) protein family, characterized by the presence of an N- terminal RBCC pattern, consisting of a RING domain, one or two B-boxes and a coiled-coil domain. PML was identified in acute promyelocytic leukemia, a disease caused by the chromosomal translocation t(15 ;17), which fuses the PML and RARA genes, leading to the synthesis of a chimeric protein PML-RARA . Arsenic trioxide (As2O3) targets the PML moiety of the oncogenic protein, resulting in its degradation and in the complete remission of patients.In healthy cells, PML transcripts derived from a single gene generate seven major isoforms of PML by alternative splicing, including six nuclear (PMLI to PMLVI) and one cytoplasmic (PMLVIIb). All share the same N-terminus but differ at their C-terminus, giving each isoform specific functions.PML is the organizer of a multi-protein structure called nuclear bodies (NBs) that are involved in various cellular processes such as apoptosis, protein degradation or antiviral defense.PML is covalently modified by SUMO at three lysine residues (K65, K160, K490) but also non-covalently via its SIM domain (for « SUMO Interacting Motif »). These modifications are required for the formation of functional NBs and the recruitment of partner proteins within them.The aim of my thesis was to study the differential role of the different PML isoforms in response to As2O3 and during viral infection.We have shown that the SIM PML SIM is necessary for its degradation in response to As2O3. This motif is present in all PML isoforms, except the nuclear PMLVI and the cytoplasmic PMLVIIb isoforms. The SIM of PML is not required for its SUMOylation and its interaction with RNF4 (the E3 ubiquitin ligase responsible for PML proteasome-dependent degradation). However, this motif is required for the ubiquitination of PML, the recruitment of proteasome components and the degradation of PML in response to As2O3.Concerning the antiviral properties of PML, the study that we conducted with all PML isoforms allowed us to show that only PMLIII and PMLIV confer resistance to Vesicular Stomatitis Virus (VSV). Whereas the antiviral activity of PMLIII is only observed at low multiplicity of infection (MOI) and is independent of IFN production, PMLIV has a potent anti-VSV activity, including at high MOI, which is mediated through two distinct mechanisms: (i) PMLIV inhibits the replication of VSV by an early and IFN-independent mechanism, (ii) PMLIV later increases the production of IFN-β via a stronger activation of IRF3, which is due to the specific sequestration of Pin1 by PMLIV within NBs. Both processes require the PMLIV SUMOylation. These results show that PMLIV has an intrinsic antiviral activity and is also involved in innate immunity by positively regulating the transduction pathway leading to IFN-β synthesis

APA, Harvard, Vancouver, ISO, and other styles

7

Talga, Jaqueline Vilas Boas [UNESP]. "Linhagens em movimento: reflexões a partir das culturas iorubas." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/158317.

Full text

Abstract:

Submitted by Jaqueline Vilas Boas Talga (jtalga@yahoo.com.br) on 2018-11-14T13:16:32Z No. of bitstreams: 1 Tese_Jaqueline Vilas Boas Talga_Linhagens em movimento_reflexões a partir das culturas iorubas.pdf: 5584361 bytes, checksum: 9d6226c92bd0fecd707d6fe6b4a32b4d (MD5) Approved for entry into archive by Milena Maria Rodrigues null (milena@fclar.unesp.br) on 2018-11-21T18:51:44Z (GMT) No. of bitstreams: 1 talga_jvb_dr_arafcl.pdf: 5584361 bytes, checksum: 9d6226c92bd0fecd707d6fe6b4a32b4d (MD5) Made available in DSpace on 2018-11-21T18:51:44Z (GMT). No. of bitstreams: 1 talga_jvb_dr_arafcl.pdf: 5584361 bytes, checksum: 9d6226c92bd0fecd707d6fe6b4a32b4d (MD5) Previous issue date: 2018-09-19 Este trabalho tem por propósito apreender e discutir as concepções e práticas dos movimentos de adeptos e sacerdotes dos cultos ancestrais iorubas, entre o Golfo de Benin e o Brasil. Trata-se de um relato etnográfico focado nos movimentos atuais, cuja notável recorrência, inscrita em sucessivas trajetórias de vida, conduz ao questionamento de sua profundidade temporal, como de sua própria inteligibilidade na tessitura de laços linhageiros. A partir do cotejamento de esparsas referências disponíveis a trajetórias de vida que remontam à constituição de cidades estados em território ioruba em África e terreiros de Cambomblés no Brasil, ainda à vigência do regime escravagista, distinguimos uma parcela de africanos livres, libertos e seus descendentes que forjaram, ora por vontade, ora por imposições, as movimentações de retorno ao continente africano, ou mesmo, de contínuas viagens dos dois lados do oceano Atlântico. Consideramos a seguir, de modo particular, dentre os retornados e os viajantes, os que irão formar redes sociorreligiosas de transeuntes, e redes sociorreligiosas de matrimônios transatlânticos. Já no início do século XX passamos a notar nas movimentações estabelecidas por simpatizantes, iniciados ou não no culto dos Orixás, a participação destacada de intelectuais e artistas que passam a intermediar trocas entre adeptos dos dois lados do Atlântico. No período mais recente das movimentações, percebemos novas nuances incidentes nas motivações para a travessia do Atlântico Sul, dentre elas algumas promovidas pelos desdobramentos não esperados de convênios bilaterais entre Brasil e Nigéria, e de modo especial, as incitadas pelo movimento de africanização dos cultos brasileiros que reacende a busca direta dos ritos dirigidos por sacerdotes iorubas nigerianos, tanto no Brasil como em África The purpose of this work is to apprehend and discuss the conceptions and practices of movements made by addherents, religious people of Ifá between the Benins Gulf and Brazil. It is an ethnographic study focused on current movents, which are frequently reveiling life trajectories and it leads to the question of temporal deepness of the lineages. It departs from the scattered literature available and from the life trajectories that resembles to the constitution of State cities in ioruba territory in Africa and Camdomblés terreiros in Brasil. We distinguish different groups, such as free Africans, former-saves and their descendents who constructed the movements of return to the African continent, connenting the both sides of the Atlantic Ocean. In the most recent period of the movements, we noticed new characteristics in the motivs for the journey, among them some promoted by unexpected consequences of the official bilateral projects between Brazil and Nigeria. Specially, we emphacize the movement of the Africanization of Brazilian worships that pushes the direct search for rituals led by Nigerian iorubas both in Brazil and in Africa.

APA, Harvard, Vancouver, ISO, and other styles

8

Rukavina, Ivan. "Cyber-physics intrinsic modelling for smart systems." Thesis, Compiègne, 2021. http://bibliotheque.utc.fr/EXPLOITATION/doc/IFD/2021COMP2581.

Full text

Abstract:

Dans le cadre de cette thèse, une approche de calcul de couplage multi-échelle et multi-physique en 2D et en 3D est présentée. La modélisation multi-échelle d’une structure consiste de l’échelle macro qui représente la réponse homogénéisée de la structure entière, tandis que l’échelle micro peut capturer les détails du comportement à la petite échelle du matériau, où des mécanismes inélastiques, tels que la plasticité ou l’endommagement, peuvent être pris en compte. L’intérieur de chaque macro-élément est rempli par le maillage à l’échelle micro qui s’y adapte entièrement. Les deux échelles sont couplées à travers le champ de déplacements imposé à l’interface. Le calcul par éléments finis est effectué, en utilisant une procédure de solution operator-split sur les deux échelles. En 2D, une discontinuité dans le champ de déplacements est introduite à l’échelle macro dans un élément fini Q4, pour pouvoir capturer l’adoucissement comportement d’un matériau piézoélectrique. Un degré de liberté supplémentaire qui représente le voltage est ajouté aux noeuds des macro-éléments de tétraèdre et d’hexaèdre en 3D. La poutre de Timoshenko comportant un modèle de commutation de polarisation est utilisée à l’échelle micro. Également, une formulation multi-échelle de Hellinger-Reissner a été développée et implémentée pour un simple patch test en électrostatique. La procédure proposée est mise en œuvre dans le logiciel de calcul par éléments finis FEAP - Finite Element Analysis Program. Pour simuler le comportement aux deux échelles, FEAP est modifié, et deux versions différentes du code sont obtenues - macroFEAP et microFEAP. Le couplage de ces codes est réalisé avec Component Template Library - CTL qui rend possible l’échange d’informations entre les deux échelles. Les capacités de cette approche multi-échelle en 2D et en 3D sont démontrées dans un environnement purement mécanique, mais aussi multi-physique. La formulation théorique et l’application algorithmique sont présentées, et les avantages de la méthode multi-échelle pour la modélisation des matériaux hétérogènes sont illustrés avec plusieurs exemples numériques In this thesis, a multi-scale and multi-physics coupling computation procedure for a 2D and 3D setting is presented. When modeling the behavior of a structure by a multi-scale method, the macro-scale is used to describe the homogenized response of the structure, and the micro-scale to describe the details of the behavior on the smaller scale of the material where some inelastic mechanisms, like damage or plasticity, can be taken into account. The micro-scale mesh is defined for each macro-scale element in a way to fit entirely inside it. The two scales are coupled by imposing a constraint on the displacement field over their interface. The computation is performed using the operator split solution procedure on both scales, using the standard finite element method. In a 2D setting, an embedded discontinuity is implemented in the Q4 macroscale element to capture the softening behavior happening on the micro-scale. For the micro-scale element, a constant strain triangle (CST) is used. In a 3D setting, a macro-scale tetrahedral and hexahedral elements are developed, while on the micro-scale Timoshenko beam finite elements are used. This multi-scale methodology is extended with a multi-physics functionality, to simulate the behavior of a piezoelectric material. An additional degree of freedom (voltage) is added on the nodes of the 3D macro-scale tetrahedral and hexahedral elements. For the micro-scale element, a Timoshenko beam element with added polarization switching model is used. Also, a multi-scale Hellinger- Reissner formulation for electrostatics has been developed and implemented for a simple electrostatic patch test. For implementing the proposed procedure, Finite Element Analysis Program (FEAP) is used. To simulate the behavior on both macro and micro-scale, FEAP is modified and two different version of FEAP code are implemented – macroFEAP and microFEAP. For coupling, the two codes are exchanging information between them, and Component Template Library (CTL) is used. The capabilities of the proposed multi-scale approach in a 2D and 3D pure mechanics settings, but also multi-physics environment have been shown. The theoretical formulation and algorithmic implementation are described, and the advantages of the multi-scale approach for modeling heterogeneous materials are shown on several numerical examples

APA, Harvard, Vancouver, ISO, and other styles

9

Malak, Saly. "Optical localization of multiple micro-conveyors mobile over smart surfaces." Thesis, Compiègne, 2019. http://bibliotheque.utc.fr/EXPLOITATION/doc/IFD/2019COMP2526.

Full text

Abstract:

Dans le contexte de la micro-robotique, cette thèse vise à développer une méthode de localisation et de suivi optique de micro-convoyeurs se déplaçant sur une surface. Le principe de la méthode de localisation proposée consiste à détecter un faisceau réfléchi sur le micro-convoyeur et à analyser ce signal optique pour obtenir les positions correspondantes. Les principaux éléments du système sont un rétroréflecteur à coin cube placé sur un micro-convoyeur et qui permet de réfléchir le signal optique dans sa direction incidente, un miroir MEMS qui permet de balayer la surface avec un éclairement laser, un séparateur de faisceau qui est un composant optique utilisé pour guider la lumière réfléchie vers un photodétecteur utilisé pour assurer la localisation et le suivi à travers l’exploitation du signal détecté par ce dernier. L’importance de la localisation est d’optimiser la trajectoire suivie par les micro-convoyeurs en contrôlant leur position et leur vitesse pour finalement pouvoir localiser les micro-convoyeurs avec une grande précision et éviter d’éventuelles collisions entre eux. Pour faire des tests expérimentaux et évaluer le capteur développé, la surface utilisée est une surface de micro-convoyage basée sur un principe électromagnétique, développée au laboratoire Roberval. Une calibration du système, en utilisant l’homographie, a été effectuée afin d’assurer la localisation et le suivi du micro-convoyeur pour après contrôler sa trajectoire et sa vitesse. Une localisation et un suivi simultané de deux micro-convoyeurs en utilisant un multiplexage temporel a été également développé et validé dans ce travail This thesis aims to develop a method for optical localization and tracking of microconveyors moving over a surface in the context of micro-robotics. The principle of the proposed localization method consists of detecting a beam that is reflected on the micro-conveyor and analyzing this optical received signal to obtain the corresponding positions. The main elements of the system are a corner cube reflector, a MEMS mirror and a beam splitter. The corner cube is placed on the micro-conveyor in order to allow the optical signal to be reflected in its incident direction. The MEMS mirror allows the surface to be scanned with the laser. As for the beam splitter, it is an optical component used to guide the reflected light to a photodetector which is in turn used for localization and tracking through the exploitation of the signal that it detects. The important role of localization is to optimize the trajectory followed by the micro-conveyors. This could be achieved by controlling the respective position and speed of each of them in order to be finally able to localize the micro-conveyor with high precision and to avoid possible collisions between them. The surface used is a micro-conveying surface based on an electromagnetic principle, developed at the Roberval laboratory. The surface is used to perform experimental tests and to evaluate the developed sensor. A system calibration, using homography, was carried out in order to ensure the localization and tracking of the micro-conveyor, and then to control its trajectory and speed. Simultaneous localization and tracking of two micro-conveyors using time division multiplexing was also developed and validated in this work. An application of the thesis at the macroscopic scale is presented as well through applying free space optical communication between two mobile systems controlled by closed-loop optical tracking. Each system includes an active transmitter and a receiver (instead of a passive corner cube reflector in the case of the micro-conveyor). The system is driven by two servomotors which permit it to have free movement in three-dimensional space. The two modules must be aligned in order to be able to send and receive information by laser and thus communicate. In this case, a high-precision tracking system which is capable of aligning the two moving modules is required

APA, Harvard, Vancouver, ISO, and other styles

10

Bach, Dang Phong. "Development of a finite element strategy for the modeling of nano-reinforced materials." Thesis, Compiègne, 2020. http://bibliotheque.utc.fr/EXPLOITATION/doc/IFD/2020COMP2550.

Full text

Abstract:

La modélisation des matériaux nano-renforcés nécessite de prendre en compte l’effet de taille induit par les phénomènes locaux à l’interface entre la nanoinclusion et la matrice. Cet effet de taille est interprété par une augmentation du rapport interface/volume et peut être pris en compte en introduisant une élasticité surfacique à l’interface. Alors que de nombreux travaux ont été développés du point de vue analytique, peu de contributions ont trait à la description numérique et à la mise en œuvre de cette élasticité surfacique dans la méthode des éléments finis (FEM). Nos études visent à développer des outils numériques efficaces basés sur la FEM pour la modélisation de nanocomposites. Dans un premier temps, nous évaluons les deux stratégies numériques existantes, à savoir l’approche XFEM et l’approche des éléments d’interface, dans la reproduction de l’effet de taille dans le processus d’homogénéisation. Deuxièmement, sur la base d’un test de performance des trois types de formulations d’E-FEM dans le cas de discontinuités faibles, nous proposons une formulation améliorée de SKON permettant d’intégrer l’effet d’une interface cohérente. Enfin, la modélisation numérique du comportement non linéaire des nanocomposites est étudiée. Lors de la première étape, une loi élastoplastique de type von Mises avec durcissement linéaire isotrope est considérée pour le volume, tandis que l’interface est considérée comme élastique linéaire The modelization of nano-reinforced material requires to take into account the size effect caused by the local phenomena at the interface between the nano-inclusion and the matrix. This size effect is interpreted through an increase in the ratio interface/volume and can be taken into account by introducing a surface elasticity at the interface. Whereas a lot of works have been developed from the analytical point of view, few contributions are related to numerical description and implementation of such surface elasticity in Finite Element Method (FEM). Our studies aim to develop efficient numerical tools based on FEM for the modeling of nanocomposites. Firstly, we evaluate the two existent numerical strategies namely the XFEM approach and the Interface element approach in reproducing the size effect in the homogenization process. Secondly, based on a performance test on the three types of formulations of E-FEM for the case of weak discontinuity, we propose an enhanced SKON formulation allowing to incorporate the effect of a coherent interface. Finally, the numerical modeling on the nonlinear behavior of nanocomposites is investigated. In the first step, a von Mises type elastoplastic law with linear isotropic hardening is considered for the bulk while the interface is considered as linear elastic

APA, Harvard, Vancouver, ISO, and other styles

11

Dagmey, Aurélien. "Enrichissement d’huiles alimentaires riches en acides gras polyinsaturés, par des composés phénoliques d’origine naturelle, afin de les protéger de la peroxydation lipidique, en vue d’une encapsulation pour augmenter la durée de conservation de ces huiles." Thesis, Compiègne, 2020. http://bibliotheque.utc.fr/EXPLOITATION/doc/IFD/2020COMP2553.

Full text

Abstract:

Les acides linoléique (LA) et α-linolénique (ALA) sont deux acides gras polyinsaturés. Ils sont indispensables à l’Homme car nous sommes incapables de les synthétiser in situ. Ces deux acides gras sont les représentants des oméga-6 (LA) et oméga-3 (ALA). Bien qu’ils soient indispensables et donc nécessaires, l’enjeu du ratio oméga-6/oméga-3 entre ces deux familles est également important à prendre en compte dans l’alimentation. Les habitudes de consommation des Français, ces trente dernières années, ont fait évoluer la balance en défaveur des oméga-3 par rapport aux oméga-6. Or un rééquilibre de la balance oméga-6/oméga-3 tend à diminuer les risques cardiovasculaires. Les huiles de lin et de cameline sont des cultures endémiques en France extrêmement riches en ALA. Elles sont les plus adaptées à une complémentation en oméga-3 d’origine végétale. Cependant, les hautes teneurs en acides gras polyinsaturés de ces huiles sont responsables de leurs faibles stabilités oxydatives. La consommation d’huiles ou de graisses oxydées n’est pas recommandée car elle peut apporter des molécules toxiques. Ainsi l’enjeu de ce projet était d’améliorer la durée de conservation d’huiles riches en acides gras polyinsaturés en valorisant les antioxydants extraits des tourteaux obtenus après trituration des graines. Parmi les molécules étudiées, l’acide gallique, l’acide caféique, le gallate de propyle ainsi que les pinorésinol et laricirésinol purifiées du lin ont montré un réel intérêt pour ralentir l’oxydation, tandis que le sécoisolaricirésinol s’est montré inefficace Linoleic (LA) and α-linolenic (ALA) acids are two polyunsaturated fatty acids. They are essential for humans because we are unable to synthesize them in situ. These two fatty acids are the representatives of omega-6 (LA) and omega-3 (ALA). Although they are essential and therefore necessary, the issue of the omega-6 / omega-3 ratio between these two families is also important to take into account in the diet. The consumption habits of the French over the past thirty years have shifted the balance against omega-3s compared to omega-6s. Or a rebalancing of the omega-6 / omega-3 balance tends to reduce cardiovascular risks. Linseed and camelina oils are endemic crops in France extremely rich in ALA. They are the most suitable for supplementation with omega-3 of plant origin. However, the high contents of polyunsaturated fatty acids in these oils are responsible for their low oxidative stabilities. The consumption of oxidized oils or fats is not recommended because they can contribute toxic molecules. The aim of this project was to improve the shelf life of oils rich in polyunsaturated fatty acids by enhancing the antioxidant extracts of the cakes obtained after crushing the seeds. Among the molecules studied, gallic acid, caffeic acid, propyl gallate as well as pinoresinol and lariciresinol purified from flax showed a real interest in slowing down oxidation, while secoisolariciresinol was ineffective

APA, Harvard, Vancouver, ISO, and other styles

12

Welte, Anthony. "Spatio-temporal data fusion for intelligent vehicle localization." Thesis, Compiègne, 2020. http://bibliotheque.utc.fr/EXPLOITATION/doc/IFD/2020COMP2572.

Full text

Abstract:

La localisation précise constitue une brique essentielle permettant aux véhicules de naviguer de manière autonome sur la route. Cela peut être atteint à travers les capteurs déjà existants, de nouvelles technologies (Iidars, caméras intelligentes) et des cartes haute définition. Dans ce travail, l'intérêt d'enregistrer et réutiliser des informations sauvegardées en mémoire est exploré. Les systèmes de localisation doivent permettre une estimation à haute fréquence, des associations de données, de la calibration et de la détection d'erreurs. Une architecture composée de plusieurs couches de traitement est proposée et étudiée. Une couche principale de filtrage estime la pose tandis que les autres couches abordent les problèmes plus complexes. L'estimation d'état haute fréquence repose sur des mesures proprioceptives. La calibration du système est essentielle afin d'obtenir une pose précise. En gardant les états estimés et les observations en mémoire, les modèles d'observation des capteurs peuvent être calibrés à partir des estimations lissées. Les Iidars et les caméras intelligentes fournissent des mesures qui peuvent être utilisées pour la localisation mais soulèvent des problèmes d'association de données. Dans cette thèse, le problème est abordé à travers une fenêtre spatio-temporelle, amenant une image plus détaillée de l'environnement. Le buffer d'états est ajusté avec les observations et toutes les associations possibles. Bien que l'utilisation d'amers cartographiés permette d'améliorer la localisation, cela n'est possible que si la carte est fiable. Une approche utilisant les résidus lissés a posteriori a été développée pour détecter ces changements de carte Localization is an essential basic capability for vehicles to be able to navigate autonomously on the road. This can be achieved through already available sensors and new technologies (Iidars, smart cameras). These sensors combined with highly accurate maps result in greater accuracy. In this work, the benefits of storing and reusing information in memory (in data buffers) are explored. Localization systems need to perform a high-frequency estimation, map matching, calibration and error detection. A framework composed of several processing layers is proposed and studied. A main filtering layer estimates the vehicle pose while other layers address the more complex problems. High-frequency state estimation relies on proprioceptive measurements combined with GNSS observations. Calibration is essential to obtain an accurate pose. By keeping state estimates and observations in a buffer, the observation models of these sensors can be calibrated. This is achieved using smoothed estimates in place of a ground truth. Lidars and smart cameras provide measurements that can be used for localization but raise matching issues with map features. In this work, the matching problem is addressed on a spatio-temporal window, resulting in a more detailed pictur of the environment. The state buffer is adjusted using the observations and all possible matches. Although using mapped features for localization enables to reach greater accuracy, this is only true if the map can be trusted. An approach using the post smoothing residuals has been developed to detect changes and either mitigate or reject the affected features

APA, Harvard, Vancouver, ISO, and other styles

13

Vinardi, Carine. "Les défis du Lean à l’ère de la mondialisation et de l’industrie 4.0." Thesis, Compiègne, 2019. http://bibliotheque.utc.fr/EXPLOITATION/doc/IFD/2019COMP2500.

Full text

Abstract:

Les entreprises multinationales ou transnationales, dont le nombre ne cesse d’augmenter, présentent la particularité d’avoir des salariés présents sur les différents continents, travaillant avec des rythmes et des cultures différentes. Dans le cadre des activités des entreprises, de plus en plus de salariés sont amenés à travailler en équipe multiculturelle et délocalisée. Ces mêmes entreprises sont à la recherche des meilleures performances opérationnelles et le déploiement de la démarche Lean est un levier reconnu d’obtention des meilleures performances de manière pérenne et ce depuis des dizaines d’années. En parallèle, depuis le développement d’internet et des nouvelles technologies, de nouveaux outils deviennent disponibles pour collecter et analyser les données ou encore pour produire. Au sein des entreprises et alors que les impacts sont souvent traités de manière séparés, c’est bien de manière systémique et en même temps qu’interagissent les dimensions culturelles, le déploiement du Lean et la mise en œuvre des outils liés à l’ère numérique. Dans un soucis ultime performance pérenne, c’est bien l’efficacité du système dans sa globalité dont il est question. Ce mémoire propose de faire un état des lieux séparé puis synchronisé et de proposer une aide à l’évaluation et à la mise en œuvre cohérente de l’ensemble des trois éléments Multinational or transnational companies, whose number is constantly increasing, have the particularity of having employees working on different continents, having different rhythms and culture. More and more employees are required to work in multicultural and remote teams as part of their business activities. These same companies are looking for the best operational performance and the deployment of the Lean approach is a recognised lever for obtaining the best performance in a sustainable manner and has been for decades. In parallel, since the development of the Internet and digital technologies, new tools have become avaible to collect and analyse data or to manufacture. Within companies, while the impacts are often processed separately, it is indeed in a systemic way and at the same time that the cultural dimensions, the deployment of Lean and the implementation of tools linked to the digital era. With the ultimate aim of sustainable performance it is the efficiency of the system as a whole that is at stake. This thesis proposes to review of industrial situations, and to propose an support for the evaluation and consistent implementation of all three elements i.e culture, Lean and digitalization

APA, Harvard, Vancouver, ISO, and other styles

14

Mahut, Fabien. "Intégration des approches PLM et SLM pour le développement et la gestion des Systèmes Produit-Service en contexte automobile : proposition d’un cadre méthodologique." Thesis, Compiègne, 2019. http://bibliotheque.utc.fr/EXPLOITATION/doc/IFD/2019COMP2473.

Full text

Abstract:

Ces travaux de thèse portent sur le développement et la gestion des Systèmes Produit-Service (ou Product-Service Systems, PSS) automobiles. Ces nouvelles offres intégrées de produits et services comportent des spécificités qui obligent à dépasser les démarches de développement des produits historiques considérés. Dans un état de l’art, ces travaux s’intéressent aux cadres méthodologiques pour le développement des PSS. Le premier niveau de ces cadres, focalisé sur les approches d’ingénierie, porte sur le Service Lifecycle Management (SLM) et son interaction avec le Product Lifecycle Management (PLM). Le deuxième niveau du cadre méthodologique s’intéresse aux processus et méthodes de développement des systèmes et PSS. Le troisième niveau du cadre méthodologique s’intéresse aux modélisations de PSS. La proposition est définie à travers les trois niveaux du cadre méthodologique, en respect de 7 critères retenus pour l’ingénierie des PSS. Elle repose sur un schéma d’interaction entre le PLM et le SLM détaillé, supportant un processus de développement, intégrant les pratiques de gestion de la diversité et d’Ingénierie Système. L’ensemble est cohérent avec une modélisation des PSS intégrant les architectures système, et basé sur le FBS et le triplet Result-Ressource-Process essentiels à la description du service. Deux cas d’étude ont permis d’expérimenter cette proposition. Le premier cas d’étude, portant sur un PSS existant et maitrisé, s’est traduit en la spécification d’un outil d’amélioration de la qualité du service. Le deuxième cas d’étude porte sur un PSS de diagnostic connecté et permet d’illustrer la proposition pour supporter son déploiement dans l’entreprise This research work is exploring the development and management of Product-Service Systems. These new integrated offers go along with specific issues which challenge the current product development strategies. Analyzing the academic literature on this matter, this work focuses on methodological frameworks for the development of PSS offers. The first level of these frameworks is about engineering approaches considers Service Lifecycle Management (SLM) and Product Lifecycle Management (PLM) interactions. The second level is about specific systems or PSS development processes and methods. The third and last level challenges the definitions of a PSS model. Fed by this review, this work provides a coherent proposal for PSS development across these three levels, qualified by 7 analysis criterias. On the first level, a detailed PLM-SLM interaction scheme is proposed. It supports a development process on the second level, alongside a PSS model based on FBS and result-resource-process triplet as a matter for service adequate description. This proposal has been experimented through two study cases. The first one, about an existing and mature PSS, enabled the development of a quality management tool. The second, about the development of a connected diagnostic PSS enabled to strengthen the illustration of the proposal for its adoption

APA, Harvard, Vancouver, ISO, and other styles

15

Silva, Sebastião Fernando da. "A FILOSOFIA DE ÒRÚNMÌLÀ-IFÁ E A FORMAÇÃO DO BOM CARÁTER." Pontifícia Universidade Católica de Goiás, 2015. http://localhost:8080/tede/handle/tede/897.

Full text

Abstract:

Made available in DSpace on 2016-07-27T13:48:42Z (GMT). No. of bitstreams: 1 SEBASTIAO FERNANDO DA SILVA.pdf: 1277846 bytes, checksum: 42c08c3da2c4490dbfd9d195149122eb (MD5) Previous issue date: 2015-09-21 This theoretical and bibliographical research aims to describe the Cult of Òrúnmìlà- Ifa, which originated from West Africa, especially from Nigeria, Benin and surrounding countries, also being practiced in Brazil. Therefore, we sought to understand the yoruba culture, a little of its history and characteristics. For understanding the Òrúnmìlà-Ifa philosophy is critical to apply the interpretive analysis of the Yoruba´s worldview. The worldview of this people is based on a hierarchically structured system from a Supreme Being, called Olodumare, arch-deities, ancestors, natural phenomena and Orisa. It´s holy city, Ilé-Ife, is considered by the Yoruba as the origin of mankind. The Yorubas perform various ceremonies and rites of passage to iniciate people in Òrúnmìlà-Ifa, one arch-divinity, a spirit, an adviser of Olodumare, with transit between heaven and earth, responsible for organizing and ordering the world´s pathaways of the good and peace, creating then a cult with his name. It is noteworthy the ancestry cult, being the ancestor a person or entity revered for his-hers virtues and ethical and moral teachings. The Yoruba respect and obey the elders, whose values are orally passed from generation to generation, forming an model of principles meant to shape the formation of good character (Ìwàpèlè), peace, peaceful coexistence and respect for others, animals and nature. With the Africans diaspora, the Cult of Òrúnmìlà-Ifa (and others) had been spread to several countries, including Brazil. The Cult of Òrúnmìlà-Ifa has its own philosophy that leads people to form self-awareness and driving the social and religious life of the community. Esta pesquisa de cunho teórico-bibliográfico tem por objetivo descrever o Culto de Òrúnmìlà-Ifá, que é originário da África Ocidental, especialmente da Nigéria, Benin e países circunvizinhos, sendo também praticado no Brasil. Para tanto, buscou-se entender a cultura yorubana, um pouco da sua história e características. Para a compreensão da Filosofia de Òrúnmìlà-Ifá é fundamental a análise interpretativa da cosmovisão dos Yorùba. A cosmogonia desse povo constitui-se de um sistema estruturado hierarquicamente a partir de um Ser Supremo, denominado Òlódùmarè, arqui-divindades, ancestrais, fenômenos da natureza e orisá. A sua cidade sagrada, Ilé-Ifé, é considerada pelos Yorùba como a origem da humanidade. Eles realizam cerimônias diversas e ritos de passagem para formarem iniciados em Òrúnmìlà-Ifá, uma arqui-divindade, um espírito, um conselheiro de Òlódùmarè, com trânsito entre o céu e a terra, encarregado de organizar e ordenar o mundo nos caminhos do bem e da paz, criando-se então um culto com o seu nome. Destaca-se nessa cultura a ancestralidade, sendo o ancestral uma pessoa ou entidade reverenciada por suas virtudes e ensinamentos éticos e morais. Os Yorùba respeitam e obedecem aos anciães, cujos valores são passados, oralmente, de geração em geração, formando um ideário de princípios voltados para a formação do bom caráter (Ìwàpèlè), da paz, da convivência harmoniosa e de respeito ao outro, aos animais e à natureza. Com a diáspora dos africanos, o Culto de Òrúnmìlà-Ifá (e outros) foi difundido por diversos países, inclusive o Brasil. O Culto de Òrúnmìlà-Ifá apresenta uma filosofia própria, que leva as pessoas a formarem a consciência de si e que dirige a vida social e religiosa da comunidade.

APA, Harvard, Vancouver, ISO, and other styles

16

Paulukat, Jens. "Regulation of IL-18 binding protein by IFN-[gamma] [IFN-gamma]." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969682123.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Chen, Shu. "Studies on interferon (IFN) induction and isolation of IFN-inducing mutant viruses." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/1678.

Full text

Abstract:

The interferon (IFN) system is a powerful antiviral defense system. Host cell pattern recognition receptors (PRRs) recognise pathogen-associated molecule patterns (PAMPs) which when activated, lead to the transcription of the IFN-β gene. As a consequence IFN is secreted from the cell and activates the JAK-STAT pathway to up-regulate the transcription of IFN-stimulated genes (ISGs). The products of many ISGs inhibit viral replication and cell proliferation. Viruses encode IFN antagonists that dampen down the IFN response, making it less effective. However, within a virus population, there are always likely to be naturally occurring mutant viruses that have lost the ability to circumvent the host IFN response, and if isolated, these viruses would be unlikely to cause severe disease in the host and may therefore be developed as live attenuated virus vaccine candidates. To develop a methodology to rapidly isolate IFN-inducing mutant viruses, we generated an A549 reporter cell-line in which expression of GFP was driven by the IFN-β promoter. Using this cell-line, we show that the number of cells that became positive for GFP correlated with the amount of IFN secreted by the infected cells and the number of defective interfering (DI) particles within the virus preparations. However, we were unable to isolate IFN-inducing mutant viruses using the A549/pr(IFN-β).GFP cell-line(s). Possible reasons for this may be either that, in cells infected by IFN-inducing mutant viruses, an antiviral state was established independent of IFN that prevented virus replication in the reporter cells in which the IFN-β promoter was activated; or the viruses that activated the IFN-β promoter were DIs only which were not be able to replicate without non-defective helper viruses. A549/pr(IFN-β).GFP cells are also being used for high throughput assays to screen chemical libraries for compounds that block IFN induction. Such compounds may be potential candidates for anti-inflammatory drugs.

APA, Harvard, Vancouver, ISO, and other styles

18

Goodsall, Timothy Mark. "The swift IFU Detector system and IFU observations of z~3 galaxies." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510964.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Cai, Di. "IfD - information for discrimination." Thesis, University of Glasgow, 2004. http://theses.gla.ac.uk/3972/.

Full text

Abstract:

The problem of term mismatch and ambiguity has long been serious and outstanding in IR. The problem can result in the system formulating an incomplete and imprecise query representation, leading to a failure of retrieval. Many query reformulation methods have been proposed to address the problem. These methods employ term classes which are considered as related to individual query terms. They are hindered by the computational cost of term classification, and by the fact that the terms in some class are generally related to some specific query term belonging to the class rather than relevant to the context of the query. In this thesis we propose a series of methods for automatic query reformulation (AQR). The methods constitute a formal model called IfD, standing for Information for Discrimination. In IfD, each discrimination measure is modelled as information contained in terms supporting one of two opposite hypotheses. The extent of association of terms with the query can thus be defined based directly on the discrimination. The strength of association of candidate terms with the query can then be computed, and good terms can be selected to enhance the query. Justifications for IfD are presented from several aspects: formal interpretations of information for discrimination are introduced to show its soundness; criteria are put forward to show its rationality; properties of discrimination measures are analysed to show its appropriateness; examples are examined to show its usability; extension is discussed to show its potential; implementation is described to show its feasibility; comparisons with other methods are made to show its flexibility; improvements in retrieval performance are exhibited to show its powerful capability. Our conclusion is that the advantage and promise IfD should make it an indispensable methodology for AQR, which we believe can be an effective technique for improvement in retrieval performance.

APA, Harvard, Vancouver, ISO, and other styles

20

Hering, Annette. "Analysen zur IFN-[gamma]-Induktionskinetik [IFN-gamma-Induktionskinetik] von humanen naiven Th-Zellen." [S.l.] : [s.n.], 2002. http://www.diss.fu-berlin.de/2002/170/index.html.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Gage, Zoe O. "Interferon, viruses and drug discovery." Thesis, University of St Andrews, 2017. http://hdl.handle.net/10023/10127.

Full text

Abstract:

The interferon (IFN) response is a crucial component of cellular innate immunity, vital for controlling virus infections. Dysregulation of the IFN response however can lead to serious medical conditions including autoimmune disorders. Modulators of IFN induction and signalling could be used to treat these diseases and as tools to further understand the IFN response and viral infections. We have developed cell-based assays to identify modulators of IFN induction and signalling, based on A549 cell lines where a GFP gene is under the control of the IFN-β promoter (A549/pr(IFN-β).GFP) and the ISRE containing MxA promoter (A549/pr(ISRE).GFP) respectively. The assays were optimized, miniaturized and validated as suitable for HTS by achieving Z' Factor scores >0.6. A diversity screen of 15,667 compounds using the IFN induction reporter assay identified 2 hit compounds (StA-IFN-1 and StA-IFN-4) that were validated as specifically inhibiting IFNβ induction. Characterisation of these molecules demonstrated that StA-IFN-4 potently acts at, or upstream, of IRF3 phosphorylation. We successfully expanded this HTS platform to target viral interferon antagonists acting upon IFN-signalling. An additional assay was developed where the A549/pr(ISRE).GFP.RBV-P reporter cell line constitutively expresses the Rabies virus phosphoprotein. A compound inhibiting viral protein function will restore GFP expression. The assay was successfully optimized for HTS and used in an in-house screen. We further expanded this assay by placing the expression of RBV-P under the control of an inducible promoter. This demonstrates a convenient approach for assay development and potentiates the targeting of a variety of viral IFN antagonists for the identification of compounds with the potential to develop a novel class of antiviral drugs.

APA, Harvard, Vancouver, ISO, and other styles

22

Fort, Cécile. "Les voies du transport intraflagellaire." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066404/document.

Full text

Abstract:

Les cils sont des organites essentiels chez la plupart des eucaryotes. Ils sont construits par un mécanisme appelé transport intraflagellaire (IFT). Dans cette thèse, nous avons étudié le rôle de l'IFT chez le protiste Trypanosoma brucei. Par une combinaison d'approches en vidéo-microscopie et en microscopie électronique, nous avons révélé que l'IFT est absent ou s'arrête après ciblage par ARNi de gènes requis pour le transport aller et retour. Dans ces conditions, nous avons démontré que l'IFT n'est pas nécessaire au maintien de la longueur du flagelle mature mais contrôle la distribution de plusieurs protéines non structurales. Les trains IFT transportent la tubuline, le constituant majeur de l'axonème. En collaboration avec l'équipe d'Esben Lorentzen, nous avons mis en évidence l'existence d'un module de liaison à la tubuline sur les protéines IFT74/IFT81. Par FIB-SEM, nous avons démontré que les trains IFT sont présents presque exclusivement sur seulement deux (4 et 7) des 9 doublets de microtubules du flagelle. L'utilisation de méthodes d'imagerie super résolutives par SIM, a permis de montrer sur cellules vivantes, l'existence de deux voies spécifiques pour le trafic IFT aller et retour. Cette restriction s'explique par la présence d'une polyglutamylation plus marquée de la tubuline au niveau de ces doublets. L'inhibition des enzymes responsables de la polyglutamylation freine l'accès des protéines IFT aux flagelles et interfère sévèrement avec la construction de l'organite. Ces travaux démontrent donc un rôle essentiel de la polyglutamylation, qui serait lu par les moteurs du transport intraflagellaire Cilia and flagella are essential organelles in most eukaryotes including humans. They are built by an active mechanism termed Intraflagellar Transport or IFT. During this thesis, we have investigated the role and functioning of IFT in the protist Trypanosoma brucei. Using a combination of video-microscopy and electron microscopy, we have revealed that IFT is absent or arrested upon RNAi knockdown of genes required for anterograde and retrograde transport, respectively. In these conditions, we have demonstrated that IFT is not required for maintenance of flagellum length but that IFT controls the distribution of several non-structural proteins, to the contrary of the established dogma. IFT trains transport tubulin, the main component of the axoneme. In collaboration with the team of Esben Lorentzen (MPI Munich), we have revealed the existence of a tubulin-binding domain on proteins IFT74/IFT81. Using FIB-SEM, we have demonstrated that IFT trains are present almost exclusively on only two (4 and 7) out of 9 microtubule doublets. The use of super-resolution imaging methods (work performed at the Janelia Research Institute, USA) allowed us to show for the first time in live cells the existence of two specific bidirectional paths for IFT trafficking. This restriction is explained by differential polyglutamylation on these two doublets. The inhibition of the enzymes responsible for polyglutamylation restricts the access of IFT proteins to flagella, resulting in severe impairment of flagellum elongation. This work demonstrates an essential role for polyglutamylation that could act as a “tubulin code” that would be decrypted by the motors of intraflagellar transport

APA, Harvard, Vancouver, ISO, and other styles

23

Gleria, Assunta. "La mise en œuvre d'un dispositif technique d'assainissement (eaux usées) approprié à Ile Ife, Nigéria." Paris 12, 1988. http://www.theses.fr/1988PA120059.

Full text

Abstract:

Parmi les causes des retards de developpement dans les pvd il peut y avoir la contradiction entre persistance des anciens systemes de production et le mode de production industrielle. En ce qui concerne l'assainissement des eaux usees, la culture yoruba, dont ile ife etait le centre spirituel, prevoyait des dispositifs specifiques au niveau de l'unite d'habitation et le dispositif institutionnel garantissait la mise en oeuvre et l'entretien des dispositifs de drainage au niveau de la ville-etat. Aujourd'hui a ile ife les pratiques traditionnelles survivent partiellement seulement dans le centre ville ou existe encore l'ancienne organisation sociale; dans les habitats neufs, l'initiative des particuliers est limitee et celle du dispositif institutionnel moderne est presque absente. L'etat federal nigerian, malgre les demarches de formulation de politique en matiere d'assainissement, n'a pas reussi a rendre operantes les indications relatives aux programmes. Les gouvernements des etats, sauf quelques exceptions, montrent un vide d'organisation encore plus grand et les gouvernements locaux, qui sont charges de la mise en oeuvre des dispositifs d'assainissement dans leurs territoires, n'ont pas les moyens ni les techniques pour accomplir ces taches. . Contradictions between traditional and modern system of production seem to be the most important cause of the delay in the implementation, of technical devices for sanitation of wastes water in ile ife, nigeria. Traditionally the yoruba culture dealed with specific devices for waste water sanitation, centered in the housing unit (compound). The public power of the city -state was charged of the implementation and maintenance of drainage devices at the town level presently in ile ife, traditional practices still exist, in the ancient core of the town, where still survives the traditional social organisation. In the new urbanized areas of the town, only the private initiative operates, beeing the role of the local gover nement quite absent. The implementation of sanitation policies by the federal governement of nigeria has been, up to now, almost a failure. The states governements, with some exceptions, failed to organize sanitation services; the local councils, charged of the implementation of sanitation devices in their area of governement have not financial and technical tools to reach their tasks. .

APA, Harvard, Vancouver, ISO, and other styles

24

Srinivasa, Murthy Dilip. "REAL-TIME HILBERT TRANSFORM AND AUTOCORRELATION FOR DIGITAL WIDEBAND COMMUNICATION APPLICATIONS." Wright State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1227202325.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Chau, Teresa C. "IFE, an interactive formula editor." FIU Digital Commons, 1988. http://digitalcommons.fiu.edu/etd/2117.

Full text

Abstract:

IFE, the Interactive Formula Editor is an experimental system designed, developed and implemented to propose a different approach to handle mathematical formulae. Its main characteristics are: (1) Interactive creation and edition of a mathematical formula, (2) Tex-form output for a printed version of a formula, and (3) Ability to generate a new set of characters by means of a character editor. Mathematical symbols are provided and adjusted by the system, automatically. The system also, guides the user during the formula description because it knows the syntax of the graphical representation. The system seems to be complete and perform well. The listing of the program is included, as are suggestions for further development.

APA, Harvard, Vancouver, ISO, and other styles

26

Der, Sandy D. "Regulation of IFN-Ã expression." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0001/NQ27908.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

27

Ding, Z. "Functional analysis of IP3 receptors." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598546.

Full text

Abstract:

I developed a high-throughput fluorescence polarisation (FP) binding assay using fluorescein-IP3 and purified N-terminal fragments of IP3R to examine the thermodynamics of ligand binding to IP3R. I demonstrate that at 4°C, equilibrium competition binding using 3H-IP3 and the FP assay provided similar estimates of the equilibrium dissociation constants (KD) for a variety of ligands. I showed that the IBC alone is sufficient for high-affinity binding of adenophostin A (AdA). Similar amounts of binding energy are diverted into rearranging the SD for IP3 and AdA, but they are distinguished by their binding enthalpy and entropy changes. I revealed that the enthalpy and entropy changes of the binding of 2-O-modified IP3 analogues are different, despite their similar free energy changes. These results prompted me to propose a new model to explain partial agonism of IP3R. Different cell-surface receptors have been reported to evoke Ca2+ release from different IP3-sensitive Ca2+ stores. I examined this phenomenon in fura 2-loaded HEK cells. Combined maximal concentrations of ATP and carbachol (CCh) evoked a Ca2+ response that was larger than the response to either alone, but smaller than the sum of the responses. In the absence of extracellular Ca2+, ATP evoked a Ca2+ release that was significantly larger than CCh in cells pretreated with CCh, but smaller than the ATP response in naïve cells. In the absence of extracellular Ca2+, CCh evoked a Ca2+ release that was significantly larger than ATP in cells pretreated with ATP, but smaller than the CCh response in naïve cells. These results suggest the existence of discrete agonist-specific Ca2+-stores that partially overlap.

APA, Harvard, Vancouver, ISO, and other styles

28

Borghesani, Olya. "Exploring psychotherapists\' spirituality: Influence of the Internal Family Systems model." Thesis, Virginia Tech, 2013. http://hdl.handle.net/10919/51143.

Full text

Abstract:

This qualitative study used grounded theory to understand the influence of the Internal Family Systems ("IFS") model on psychotherapists\' spirituality and the way they address spirituality in their clinical practice. Semi-structured interviews were conducted with ten psychotherapists practicing IFS model and the data were analyzed using open, axial and selective coding. Themes were organized around the two areas of inquiry in the study. Limitations of this study as well as future research and clinical implications are also discussed. Master of Science

APA, Harvard, Vancouver, ISO, and other styles

29

Mojta, Carl Andrew. "Internal Family Systems' Influence on Beginning Therapists' Awareness of Internal Processes: A Qualitative Study." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/76897.

Full text

Abstract:

Unlike most marriage and family therapy (MFT) models, the Internal Family Systems (IFS) model claims to focus not only on the client's but also the therapist's internal processes. Given the recent systemic focus in the MFT field on the therapists' internal processes and how to train therapists to become aware of them and their influence in the clinical work, this qualitative study used a phenomenological lens to understand: (a) whether and how IFS helps beginning therapists gain awareness of their internal processes and (b) whether and how such an awareness influences their clinical work with clients. Semi-structured individual interviews were conducted with seven beginning therapists and data were analyzed using thematic coding. Themes were organized around the two areas of inquiry in the study. Limitations of this study as well as future research and clinical implications are also discussed. Master of Science

APA, Harvard, Vancouver, ISO, and other styles

30

Schmidt, Ruth Maria. "Signalkaskaden und Steuermechanismen in den Speicheldrüsen von Dipteren." Phd thesis, Universität Potsdam, 2006. http://opus.kobv.de/ubp/volltexte/2006/771/.

Full text

Abstract:

Flüssigkeitssekretion und Proteinsekretion werden in Speicheldrüsen von Insekten über Hormone und Neurotransmitter gesteuert. Diese entfalten ihre physiologische Wirkung in den sekretorischen Drüsenzellen hauptsächlich über den zyklischen Adenosinmonophosphat (cAMP)-Signalweg und den Inositoltrisphosphat (IP3) / Ca2+-Signalweg. Die Mechanismen möglicher Wechselwirkungen zwischen diesen Signalwegen und ihre physiologischen Auswirkungen sind unzureichend bekannt. Im Mittelpunkt dieser Arbeit stand die Frage, ob und wie sich der Ca2+-Signalweg und der cAMP-Signalweg in der Speicheldrüse der Diptere Calliphora vicina beeinflussen. Substanzen wie 5-Fluoro-α-Methyltryptamin und Histamin wurden in früheren Arbei-ten als Agonisten genutzt, um in den Speicheldrüsen von C. vicina selektiv den cAMP-Signalweg (getrennt vom IP3/Ca2+-Signalweg) zu aktivieren. Es zeigte sich in transepithelialen Potentialmessungen und mikrofluorometrischen Ca2+-Untersuchungen, dass beide Substanzen sowohl den cAMP-Weg als auch den Ca2+-Signalweg aktivierten. Die physiologischen Ursachen der Histamin-induzierten Ca2+-Erhöhung wurden genauer untersucht. Zusammengefasst zeigten diese Untersuchungen, dass Histamin wie 5-HT den cAMP-Weg und die Phosphoinositidkaskade aktivierte. Im Gegensatz zu den 5-HT-induzierten Ca2+-Oszillationen, welche durch interzelluläre Ca2+-Wellen synchronisiert werden, verursachte Histamin bei niedrigen Konzentrationen lokale Ca2+-Oszillationen in einzelnen Zellen (keine Wellen). Bei höheren Histamin-Konzentrationen war eine anhaltende Ca2+-Erhöhung oder ein synchrones <quote>Ca2+-beating</quote> in der gesamten Drüse zu beobachten. Des Weiteren wurde die Frage untersucht, ob eine Erhöhung der intrazellulären cAMP-Konzentration den IP3 Ca2+-Signalweg in den Epithelzellen der Speicheldrüse beeinflussen kann. Es zeigte sich, dass cAMP den durch schwellennahe 5-HT-Konzentrationen induzierten Ca2+-Anstieg verstärkte. Diese Verstärkung wurde durch eine PKA-vermittelte Sensitivierung des IP3-Rezeptor/Ca2+-Kanals für IP3 verursacht. Immunzytochemische Untersuchungen deuten dar-auf hin, dass die Proteinkinase A eng mit dem IP3-Rezeptor/Ca2+-Kanal assoziiert ist. Diese Messungen zeigen erstmals, dass auch bei Invertebraten der Botenstoff cAMP, PKA-vermittelt, den IP3-Rezeptor/Ca2+-Kanal des ER für IP3 sensitiviert. Fluid- and protein-secretion in the salivary glands of insects are controlled by hormones or neurotransmitters. These agonists activate two signalling cascades: the cAMP-pathway and the IP>sub>3/Ca-pathway. The functional crosstalk between these two signalling pathways is poorly understood. Functional crosstalk between cAMP-pathway and IP3/Ca2+-pathway was investigated in the salivary glands of the blowfly, Calliphora vicina. Histamine and 5-alpha-methyltryptamine were used in an attempt to activate the cAMP-pathway selectively, as suggested previously. By using transepithelial potential-measurements and microfluorometric Ca2+-imaging it was demonstrated that both substances activate the cAMP- and the IP3/Ca2+-pathway. The physiological effects of histamine were investigated in detail. These experiments show that histamine causes an intracellular Ca2+-elevation that, in some preparations exhibits oscillations with concentration-dependent frequencies. In contrast to 5-HT induced intracellular Ca2+-oscillations and propagating intercellular Ca2+-waves histamine produces local Ca2+-oscillations in single cells or synchronous <quote>Ca2+-beating</quote> in the whole gland. In addition the effects of increasing cAMP on the IP3/Ca2+-pathway in the salivary glands of the blowfly were studied. It could be demonstrated that cAMP augments the 5-HT-induced Ca2+-increase in glands stimulated with low doses of 5-HT. This potentiation is the result of a PKA-mediated sensitisation of the IP3-receptor/Ca2+-channel for IP3. Results of immunocytochemical analyses show that the PKA is spatially associated with the ER. These results show for the first time that in invertebrates as well as in vertebrates the second messenger cAMP sensitises the IP3-receptor/Ca2+-channel for IP3 by the action of a PKA.

APA, Harvard, Vancouver, ISO, and other styles

31

Kühnle, Simone. "The reconstitution of immunocompetence by GM-CSF or (IFN-g) [(IFN-gamma)] after pharmacological suppression." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=961227540.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Zurney, Jennifer Michelle. "Cardiac Cell Type-Specific Differences in the Interferon (IFN) Response, and Reovirus Repression of IFN." NCSU, 2008. http://www.lib.ncsu.edu/theses/available/etd-06302008-141954/.

Full text

Abstract:

Viral myocarditis is an important human disease associated with a wide variety of viruses. The cardiac damage and inflammation associated with viral myocarditis can be immune mediated and/or due to direct cytopathic effect. Reovirus-induced myocarditis reflects direct virus-mediated apoptosis of cardiac cells, providing an excellent model to study direct cytopathic effect in the heart. Previous work has found interferon-beta (IFN) to be an important determinant for protection against viral myocarditis. Importantly, IFN signals through the Jak-STAT pathway to induce the expression of interferon-stimulated genes (ISGs) and establish an antiviral state. First, we investigated the underlying mechanisms of the IFN response in these cardiac cells. We found that high basal IFN-beta expression in cardiac myocytes protects this vulnerable, nonreplenishable cardiac cell type, while high basal expression of interferon alpha receptor 1 and latent Jak-STAT components in adjoining cardiac fibroblasts renders these cells more responsive to IFN and prevents them from inadvertently serving as a virus reservoir. This provides the first evidence for an integrated network of cell-type-specific innate immune components for organ protection. Next, we investigated whether particular reovirus strains were able to repress IFN signaling. We found that the mildly myocarditic reovirus, T1L, but not the nonmyocarditic reovirus, T3D, could repress IFN induction of ISGs and that this repressor function is determined by the M1 gene of T1L. Infection with T1L or reassortant or recombinant viruses containing the T1L M1 gene results in accumulation of IRF9 in the nucleus; an effect not previously described for any virus. The M1 gene has also previously been identified as a determinant of virus strain-specific differences in the IFN response, and the M1 gene and the IFN response have been identified as determinants of virus strain-specific differences in induction of murine myocarditis. Here, we find that virus-induced myocarditis is associated with repression of IFN function, providing new insights into the pathophysiology of this disease. Together, these data provide the first report of an increase in IRF9 nuclear accumulation associated with viral subversion of the IFN response, and provide evidence that virus strain-specific differences in IFN antagonism are a determinant of disease.

APA, Harvard, Vancouver, ISO, and other styles

33

Maria, Mônica Mendonça. "Tecnologia BIM na arquitetura." Universidade Presbiteriana Mackenzie, 2009. http://tede.mackenzie.br/jspui/handle/tede/2640.

Full text

Abstract:

Made available in DSpace on 2016-04-18T12:12:29Z (GMT). No. of bitstreams: 4 Monica Mendonca Maria1.pdf: 763444 bytes, checksum: d5fe5f8d60e9e7bd08aecfc0a88b8198 (MD5) Monica Mendonca Maria2.pdf: 1212194 bytes, checksum: b5f0b63d350777866e3955220d604827 (MD5) Monica Mendonca Maria3.pdf: 1656626 bytes, checksum: c2a9d642d2e4d86b7409ce54aabebe89 (MD5) Monica Mendonca Maria4.pdf: 2215429 bytes, checksum: 64893a7cd54a8d0497c2dc13776f74e4 (MD5) Previous issue date: 2009-02-04 This dissertation presents the technology within BIM and its implication in the architectural and engineering design process. Since the 60 s, aerospace and automotive industries have already revolutionized the way of project with the CAD, and manufacture with the assembly lines. In AEC, the CAD became BIM, a new way of project, build and manage, from conception till life cycle building. This brought a project and construction time reduction, cost and environmental impacts decrease foreseen in LEED and merged in BIM. Este trabalho objetiva apresentar a tecnologia contida no BIM e suas implicações no processo de projeto da arquitetura e engenharia civil. A partir de 1960, as indústrias, aeronáutica e automotiva, já haviam revolucionado a forma de projetar com o CAD, e de fabricar com as linhas de montagem. Na Arquitetura, Engenharia e Construção, o CAD está evoluindo para o BIM (Building Information Modeling), uma forma de projetar, construir e gerenciar, da concepção ao habite-se, aplicável a todo o ciclo de vida da edificação. Dessa forma houve não só uma redução no tempo de projeto e construção, mas também em custos e impactos ambientais previstos em normas internacionais incorporadas ao BIM.

APA, Harvard, Vancouver, ISO, and other styles

34

Oliveira, Ana Marcelina de. "O papel da burocracia no processo de implantação dos Institutos Federais de Educação, Ciência e Tecnologia (IFs) : o caso do IF de Passos (MG) /." Franca, 2016. http://hdl.handle.net/11449/137854.

Full text

Abstract:

Orientador: Oswaldo Gonçalves Júnior Banca: Agnaldo de Sousa Barbosa Banca: Milena Pavan Serafim Resumo: Este trabalho aborda a política pública de educação profissional que, através do Plano de Expansão da Rede Federal de Educação Profissional, Científica e Tecnológica, proporcionou a criação dos Institutos Federais de Educação, Ciência e Tecnologia (IFs) e a abertura de novas unidades de ensino em diversas regiões do país entre os anos de 2003 e 2014. Uma dessas unidades de ensino de IF localiza-se na cidade de Passos (MG), cujo processo de implantação foi conduzido primordialmente por atores pertencentes ao próprio instituto, integrantes da burocracia pública. Esses atores ocupavam cargos comissionados próprios das Instituições Federais de Ensino (IFEs) que em correlação/equiparação com os Cargos de Direção e Assessoramento Superior (DAS) foram enquadrados como integrantes da burocracia de alto escalão do governo federal. No entanto, à medida que empiricamente se observa a atuação desses atores percebe-se que ela está bem mais relacionada ao papel desempenhado pela burocracia de médio escalão. Cavalcante e Lotta (2015, p. 13) afirmam que os Burocratas de Médio Escalão (BMEs) são atores relevantes no processo de implementação de políticas públicas e a importância dessa burocracia está justamente em ser o elo entre o alto escalão e os executores das políticas públicas. Ao estudar a política pública de educação profissional parte-se do pressuposto de que, embora sejam materializadas através dos governos, as políticas públicas envolvem vários atores e níveis de decisão (SOUZA, 2006), advertindo sobre o aspecto deliberativo e muitas vezes discricionário do processo de produção de políticas públicas. Nesse sentido, para melhor compreender a política pública de educação profissional, a criação dos institutos federais e a atuação dos atores envolvidos no processo de implantação do campus de IF na cidade de Passos (MG), este trabalho pautou-se... Abstract: This work approaches the public policy of professional education which, through the Expansion Plan of the Federal Network of Professional Education Science and Technology, provided the creation of the Federal Institutes of education, science and technology (IFs) and the opening of new units of instruction in several regions of the country between the years of 2003 to 2014. One of these teaching units IF (Federal Institute) it is located in Passos (MG), whose deployment process was conducted primarily by actors belonging to the Institute, members of the public bureaucracy. These actors were commissioned positions of the federal institutions of education (IFEs) in parity with the positions and Superior advisory services (DAS) were included as members of the senior bureaucracy of the federal Government. However, as empirically observed these actors realizes that it is much more related to the function performed by the middle ranking bureaucracy. Cavalcante and Lotta (2015, p. 13) say that the middle ranking bureaucrats (BMEs) are relevant actors in the process of implementation of public policies and the importance of this bureaucracy is precisely to be the junction between the high-level and the executors of public policies. By studying public policy professional education the assumption that, although they are materialized through Governments, public policies involve several actors and levels of decision (SOUZA 2006), warning about the deliberative and often discretionary aspect of the production process of public policies. In this sense, to better understand the public policy of professional education, the creation of federal institutions and the performance of the actors involved in the implementation process of the campus of IF located in Passos (MG), this work was in a review of literature on the topics: professional education; creation and expansion of the professional education; concepts,... Mestre

APA, Harvard, Vancouver, ISO, and other styles

35

Oliveira, Ana Marcelina de [UNESP]. "O papel da burocracia no processo de implantação dos Institutos Federais de Educação, Ciência e Tecnologia (IFs): o caso do IF de Passos (MG)." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/137854.

Full text

Abstract:

Submitted by ANA MARCELINA DE OLIVEIRA null (marcelinaeo@gmail.com) on 2016-04-08T00:47:04Z No. of bitstreams: 1 Dissertacao Ana Marcelina Oliveira Final.pdf: 1138526 bytes, checksum: a408157f4ba82bd1801e1042dc64df6e (MD5) Approved for entry into archive by Felipe Augusto Arakaki (arakaki@reitoria.unesp.br) on 2016-04-08T13:36:56Z (GMT) No. of bitstreams: 1 oliveira_am_me_fran.pdf: 1138526 bytes, checksum: a408157f4ba82bd1801e1042dc64df6e (MD5) Made available in DSpace on 2016-04-08T13:36:56Z (GMT). No. of bitstreams: 1 oliveira_am_me_fran.pdf: 1138526 bytes, checksum: a408157f4ba82bd1801e1042dc64df6e (MD5) Previous issue date: 2016-02-29 Não recebi financiamento Este trabalho aborda a política pública de educação profissional que, através do Plano de Expansão da Rede Federal de Educação Profissional, Científica e Tecnológica, proporcionou a criação dos Institutos Federais de Educação, Ciência e Tecnologia (IFs) e a abertura de novas unidades de ensino em diversas regiões do país entre os anos de 2003 e 2014. Uma dessas unidades de ensino de IF localiza-se na cidade de Passos (MG), cujo processo de implantação foi conduzido primordialmente por atores pertencentes ao próprio instituto, integrantes da burocracia pública. Esses atores ocupavam cargos comissionados próprios das Instituições Federais de Ensino (IFEs) que em correlação/equiparação com os Cargos de Direção e Assessoramento Superior (DAS) foram enquadrados como integrantes da burocracia de alto escalão do governo federal. No entanto, à medida que empiricamente se observa a atuação desses atores percebe-se que ela está bem mais relacionada ao papel desempenhado pela burocracia de médio escalão. Cavalcante e Lotta (2015, p. 13) afirmam que os Burocratas de Médio Escalão (BMEs) são atores relevantes no processo de implementação de políticas públicas e a importância dessa burocracia está justamente em ser o elo entre o alto escalão e os executores das políticas públicas. Ao estudar a política pública de educação profissional parte-se do pressuposto de que, embora sejam materializadas através dos governos, as políticas públicas envolvem vários atores e níveis de decisão (SOUZA, 2006), advertindo sobre o aspecto deliberativo e muitas vezes discricionário do processo de produção de políticas públicas. Nesse sentido, para melhor compreender a política pública de educação profissional, a criação dos institutos federais e a atuação dos atores envolvidos no processo de implantação do campus de IF na cidade de Passos (MG), este trabalho pautou-se em uma revisão de literatura sobre os temas: educação profissional; criação e expansão da rede federal de educação profissional; conceitos, enfoques e implementação de políticas públicas; e burocracia pública, com foco na burocracia de nível intermediário. Pautou-se também na realização e análise de entrevistas com três atores-chave do processo de implantação do campus do Instituto Federal de Educação, Ciência e Tecnologia do Sul de Minas Gerais em Passos (MG). Este trabalho também procura se valer dos enfoques de Avaliação de Políticas Públicas (EAv) e de Análise e Políticas Públicas (EAn), que tratam da dimensão programas sob diferentes perspectivas. Para o EAv a implantação do campus do IF atendeu às dimensões estabelecidas pelo Plano de Expansão da Rede. E com o EAn considera-se que o plano materializou a política (policy) através de seus processos políticos (politics) e instituições políticas (polity). Por fim, os atores envolvidos na implantação do campus do instituto federal em foco foram fundamentais para esse processo, sendo denominados de burocratas de alto escalão, mas atuaram conforme o papel desempenhado pela burocracia de médio escalão. Sua atuação ocorreu principalmente na intermediação de ações da política, na aplicação das diretrizes da política e na coordenação de ações entre superiores e subordinados, ou seja, em aspectos que proporcionaram a implementação da política pública de educação profissional. This work approaches the public policy of professional education which, through the Expansion Plan of the Federal Network of Professional Education Science and Technology, provided the creation of the Federal Institutes of education, science and technology (IFs) and the opening of new units of instruction in several regions of the country between the years of 2003 to 2014. One of these teaching units IF (Federal Institute) it is located in Passos (MG), whose deployment process was conducted primarily by actors belonging to the Institute, members of the public bureaucracy. These actors were commissioned positions of the federal institutions of education (IFEs) in parity with the positions and Superior advisory services (DAS) were included as members of the senior bureaucracy of the federal Government. However, as empirically observed these actors realizes that it is much more related to the function performed by the middle ranking bureaucracy. Cavalcante and Lotta (2015, p. 13) say that the middle ranking bureaucrats (BMEs) are relevant actors in the process of implementation of public policies and the importance of this bureaucracy is precisely to be the junction between the high-level and the executors of public policies. By studying public policy professional education the assumption that, although they are materialized through Governments, public policies involve several actors and levels of decision (SOUZA 2006), warning about the deliberative and often discretionary aspect of the production process of public policies. In this sense, to better understand the public policy of professional education, the creation of federal institutions and the performance of the actors involved in the implementation process of the campus of IF located in Passos (MG), this work was in a review of literature on the topics: professional education; creation and expansion of the professional education; concepts, approaches and implementation of public policies; and public bureaucracy, focusing on mid-level bureaucracy. Was also in the realization and analysis of interviews with three key actors of the deployment process of the campus - Federal Institute of education, science and technology in the South of Minas Gerais located in Passos (MG). This work also search to focus on the Evaluation of Public Policies (EAv) and Analysis and Public Policies (EAn), dealing with the dimension programs under different perspectives. For EAv implementation campus do IF met the dimensions established by the network expansion plan. And with the EAn the plan materialized to politics (policy) through their political processes (politics) and political institutions (polity). Finally, the actors involved in the implementation of the federal Institute's campus in focus were critical to this process, being named to high-level bureaucrats, but acted as the role played by mid-level bureaucracy. Its performance occurred mainly the intermediation of policy action, in the implementation of policy guidelines and coordination of actions between superiors and subordinates, on aspects that have provided the implementation of public policy professional education.

APA, Harvard, Vancouver, ISO, and other styles

36

Ruge, Marcus. "Modellierung von Stimmungen und Erwartungen in der deutschen Wirtschaft." Universität Potsdam, 2009. http://opus.kobv.de/ubp/volltexte/2009/2904/.

Full text

Abstract:

Geschäftsbeurteilungen und -Erwartungen sind bedeutende Einflussgrößen in der Wirtschaft. Vor allem durch die Ereignisse der Finanzkrise der letzten Monate nahm die Diskussion um den Einfluss solch psychologisch basierter Faktoren zu. Die schillernden Begriffe wie Beurteilungen oder Erwartungen müssen zunächst quantifiziert werden, eine Aufgabe, die in der Regel von Forschungsinstituten wie Ifo, ZEW oder Eurostat übernommen wird. Dieser Diskussionsbeitrag untersucht, welche Möglichkeiten bestehen, die aktuellen Beurteilungen und zukünftigen Erwartungen in der Wirtschaft zu messen und wie dies konkret realisiert wird. Die Arbeit umfasst eine Datenbeschreibung und eine weitergehende Datenanalyse, in der die Zusammenhänge und Entwicklungen der einzelnen Zeitreihen untersucht werden. Eine der bedeutendsten Fragestellungen ist die Qualität und Reichwerte der Prognosekraft der Erwartungen für spätere Zeithorizonte. Ein internationaler Vergleich zwischen Deutschland und ausgewählten Länder der Europäischen Union sollen einen Überblick über die gemeinsame Entwicklung verschaffen. Als statistische Methoden werden unter anderem Hauptkomponentenanalysen und Partial-Least-Squares-Modelle verwendet. This paper analyses sentiments and expectations in the German economy with Partial Least Squares models and Principal Component analysis. Sentiments or expectations are a fundamental element in theoretic economic science but there is still not sufficient empirical work in that subject. Actual Sentiments or future expectations are often considered vague theoretic constructs which should be represented by latent variables in empirical science. The manifest data could be obtained by German research institutes as Ifo, ZEW or Eurostat. Questions include the predictive power of expectations and an international comparison of the German with the European development of sentiments over the last 20 years.

APA, Harvard, Vancouver, ISO, and other styles

37

Pina, Lígia Isabel Gomes de. "Esclerose múltipla: terapêutica com IFN-β". Master's thesis, [s.n.], 2012. http://hdl.handle.net/10284/3202.

Full text

Abstract:

Trabalho apresentado à Universidade Fernando Pessoa, como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas A esclerose múltipla (EM) é a doença crónica mais comum do sistema nervoso central (SNC) e é caracterizada pela destruição da mielina. Hoje em dia é objecto de inúmeras pesquisas para determinar com precisão as suas causas e definir um tratamento eficaz. A diferente susceptibilidade à doença entre homens e mulheres, negros e caucasianos, jovens e idosos e a distribuição geográfica díspar da EM parece sugerir uma interacção efectiva entre factores genéticos e ambientais. Apesar de ser uma doença auto-imune, o tratamento com imunossupressores ficou aquém das expectativas e começaram a utilizar-se imunomoduladores como o Interferão beta (IFN-β) de modo a reduzir a frequência e a gravidade dos surtos. Multiple sclerosis is the most common chronic disease of the central nervous system and is characterized by the destruction of myelin. Nowadays is subject of numerous studies to establish accurately the causes and define an effective treatment. The different susceptibility to disease between men and women, blacks and whites, young and old and unequal geographical distribution of MS appears to suggest an effective interaction between genetic and environmental factors. Although it is an autoimmune disease, treatment with immunosuppressive agents is still poor and it was initiated the use of immunomodulators such as interferon beta (IFN-β) to reduce the frequency and severity of the attacks.

APA, Harvard, Vancouver, ISO, and other styles

38

Tran, Trinh, and Rifqa Al-sammaraie. "Användning av filformatet IFC i byggprojekt." Thesis, Malmö universitet, Fakulteten för teknik och samhälle (TS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-20033.

Full text

Abstract:

Byggnadsinformationsmodellering (BIM) kan utföras med olika programvaror som används av de olika aktörerna i ett byggprojekt. BIM medför flera fördelar för byggprocessen som till exempel modelleringsfördelar, tekniska fördelar och ekonomiska fördelar. Däremot är informationsöverföringen mellan olika 3D-program (interoperabilitet) ett problem och en av de största utmaningarna för BIM-användare idag. IFC är ett standardiserat (sedan 1997), öppet och neutralt filformat som möjliggör överföring av information mellan olika 3D-program. Syftet med denna studie var att undersöka hur hanteringen av information på IFC-format upplevs av olika aktörer som deltar i ett byggprojekt. Studien undersöker även utvecklingsmöjligheter av IFC-format utifrån användarnas perspektiv för att säkerställa smidigt och kvalitetssäkert informationsflöde i ett projekt. Frågeställningar som har behandlats är vilka möjligheter och hinder som IFC-format anses ha utifrån användarnas perspektiv, hur IFC upplevs och används av olika aktörer samt hur ett krav på att använda IFC-format upplevs av aktörer inom byggbranschen. I studien genomfördes en litteraturundersökning inom ämnet för att få förståelse för hantering av IFC-format i byggbranschen. Därefter genomfördes en kvalitativ undersökning där totalt sju aktörer från olika verksamheter intervjuades. Denna kompletterades med en kvantitativ under-sökning genom en enkätstudie. Slutsatsen i arbetet är att IFC-format är vanligt förekommande i byggprojekt. IFC-format upplevs som ett verktyg som möjliggör och underlättar kommunikation och samordning mellan modeller och discipliner. Däremot anser majoriteten av IFC-användare att IFC fortfarande är ett bristfälligt format. Litteraturstudien tillsammans med den kvantitativa och kvalitativa undersökningen visar att kunskapen om hantering av IFC-formatet brister inom byggbranschen vilket är en av anledningarna till informationsförlusterna. Flertalet av studiens deltagare var positivt inställda till att krav ställs på att IFC måste användas i byggprojekt, när formatet utvecklas ytterligare. Building information modeling (BIM) can be carried out in various software applications that are used by the different actors in a construction project. However, interoperability problems are one of the biggest challenges for BIM users today. The purpose of this study was to investigate how IFC format management is experienced by different actors in a construction project. The study also examines development opportunities of IFC format from the user’s perspectives to ensure smooth and quality-assured information flow in a project. In this research, a literature study was carried out to gain an understanding of the management of IFC format at present. A qualitative and a quantitative study was also carried out, by conducting interviews with actors from different companies and collecting data through a survey. The conclusion is that IFC format is very common in construction projects. IFC format is a tool that enables and facilitates communication and coordination between models and disciplines. However, the majority of IFC users consider that the IFC is still a defective format. The participants were primarily optimistic of the fact of IFC being a requirement within the construction industry. However, believes that further development is needed before being implemented.

APA, Harvard, Vancouver, ISO, and other styles

39

Junger, Anette. "Barns upplevelse av intensiv familjeterapi (IFT)." Thesis, Ersta Sköndal Bräcke högskola, S:t Lukas utbildningsinstitut, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-6043.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Hansted, Edita. "Specifinio imuninio atsako vertinimas diagnozuojant tuberkulioz4s infekciją vaikams." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2009~D_20090923_084330-35322.

Full text

Abstract:

Tuberkuliozė (TB) – viena grėsmingiausių, plačiai pasaulyje paplitusių lėtinių infekcinių ligų, sąlygojančių didelį mirtingumą. Savalaikė jos diagnostika, tinkamas gydymas ir profilaktika lieka vieni aktualiausių medicinos uždavinių, siekiant sėkmingos TB kontrolės. Nuo 1890 metų vienintelis metodas latentinei TB infekcijai nustatyti yra įodinis tuberkulino mėginys (ITM), pasižymintis nepakankamu jautrumu, ypač BCG vakcina vakcinuotoje populiacijoje [WHO, 2004, WHO, 2006, American Thoracic Society, 2000]. Darbo tikslas - nustatyti specifinio imuninio atsako ypatumus diagnozuojant vaikų užsikrėtimą TB. Uždaviniai: 1. Įvertinti odos reakciją į tuberkuliną asmenims, kuriems įtariama TB infekcija, ir palyginti su sergančiųjų TB tyrimo duomenimis; 2. Įvertinti ir palyginti T-limfocitų išskiriamo IFN-γ kiekį asmenims, sergantiems TB ir buvusiems kontakte su sergančiuoju užkrečiama TB; 3. Palyginti in vivo ir in vitro tyrimų diagnostinę vertę, nustatant užsikrėtimą TB infekcija; 4. Įvertinti odos reakcijos į tuberkuliną dydžio ir T-limfocitų išskiriamo IFN-γ kiekio pokyčius po gydymo vaistais nuo TB; 5. Įvertinti socialinius veiksnius, galinčius įtakoti tirtų vaikų užsikrėtimą ir sirgimą TB. Tyrimas buvo atliktas Kauno medicinos universiteto Vaikų ligų klinikoje ir Romainių tuberkuliozės ligoninėje 2005–2007 m., gavus KMU Regioninio Bioetikos komiteto leidimą (leidimas atlikti biomedicinį tyrimą 2005-05-11 Nr. BE-2-32). Tirti vaikai iš Kauno regiono, jų amžius – 10-17 metų. Visi... [toliau žr. visą tekstą] Tuberculosis (TB) is one of the oldest infectious diseases worldwide. The only method available for TB infection detection has been the tuberculin skin test (TST). Still, this tool has not proved itself as a sensitive method, especially in population previously vaccinated with BCG. The Aim of the Study: to evaluate features of specific immune response in diagnosis of TB in children. The Objectives of the Study: to assess TST in subjects who had contact with TB, and to compare with the results of patients with bacteriologically confirmed TB; to evaluate and to compare T-cell secreting IFN-γ response (T SPOT TB) in subjects with contagious TB and in subjects who had contact with TB; to compare the diagnostic value of in vivo and in vitro tests; to evaluate TST and T SPOT TB results after treatment; to assess the social factors, that may influence children to get TB. 120 subjects had been enrolled in Part I of the Study and 67 in the II. Part I. Evaluation of the immune response - 3 groups of children: “culture-confirmed TB“ group (n=23) – subjects with bacteriologically confirmed TB; “high risk for TB“ group (n=45) - subjects, who had contact with a TB-sick person; “low risk for TB“ group (n=52) – subjects with no identifiable risk for TB. Part II. children were divided into 3 groups, depending on the results of Part I of the study: Children with bacteriologically confirmed-TB (n=23); Children with latent TB infection (n=13); Healthy children (n=31). Conclusions: Positive... [to full text]

APA, Harvard, Vancouver, ISO, and other styles

41

Teodoro, Mairan Macedo. "Espectroscopia de campo integral do Homúnculo de eta Carinae." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/14/14131/tde-12042006-105530/.

Full text

Abstract:

Nesta dissertação são apresentados os resultados obtidos da espectroscopia de campo integral da nebulosa do Homúnculo. As observações foram feitas na banda J, no intervalo de 10620 Å até 12960 Å, utilizando o IFU (Integral Field Unit) do espectrógrafo CIRPASS (Cambridge Infrared Panoramic Survey Spectrograph), que possui 499 lentes hexagonais. A amostragem espacial é de 0,25"/lente e a resolução espectral, R=3200. A linha do [Fe II] λ12567 permitiu a identificação de duas estruturas no lóbulo NW que ainda não haviam sido relatadas. Através da tomografia Doppler, essas estruturas indicaram a existência de uma região de baixa densidade localizada no lóbulo NW e que não é visível nas imagens feitas na região óptica. Além disso, o Pequeno Homúnculo também foi identificado através do mapeamento das componentes e também nos mapas de velocidade da linha do [Fe II] λ12567. As regiões polares da nebulosa do Homúnculo (onde ocorre a colisão mais intensa entre o vento da fonte central e a região interna dos lóbulos) são mais opacas do que as paredes dos mesmos. Isso é verificado pela diminuição na intensidade da linha do [Fe II] λ12567 no lóbulo SE e pelo aumento desta na linha de visada do lóbulo NW. O disco equatorial foi observado nas linhas da série do H (Paβ e Paγ) e na linha do He I λ10830 como uma componente devido à emissões intrínsecas até distâncias superiores às dimensões aparentes do disco que é observado nas imagens feitas na faixa óptica. A linha do [Fe II] λ12567 também apresenta uma componente associada ao disco equatorial. Regiões de baixa densidade localizadas no toro que envolve a fonte central permitem que a radiação ultravioleta escape e excite o gás contido no disco equatorial. O melhor exemplo desse efeito foi detectado pela tomografia Doppler da linha do He I λ10830, que revelou uma componente de emissão intrínseca que atinge distâncias superiores à borda aparente do lóbulo NW do Homúnculo, e que foi completamente mapeada pela primeira vez nesta dissertação. The Homunculus nebula was mapped using the integral field technique and the results are presented in this dissertation. The observations were obtained in the J band in the range from 10620 Å to 12960 Å using the CIRPASS's IFU, which contains 499 hexagonal lenses. The spatial sampling is 0,25"/lens and the spectral resolution, set to R=3200. The [Fe II] λ12567 line allowed the identification of two structures in the NW lobe that had not been reported yet. Doppler tomography of this structures revealed a low density region placed in the NW lobe that is not seen in the optical images. Besides, the Little Homunculus was also detected both in the mapping of components of the [Fe II] λ12567 and in its velocity maps. In the Homunculus nebula, the polar regions (where the shock between the stellar bipolar wind and the internal wall of the lobes is stronger) are more opaque than the lobe walls. This can be verified by the decrease in the intensity of the [Fe II] λ12567 in the SE lobe and the enhancement of this line emission in the NW lobe. Emissions due to the equatorial disc were detected both in the H series (Paβ and Paγ) and the He I λ10830 as an intrinsic component up to distances greater than the aparent dimensions of the disc seen in the images taken in the optical range. The [Fe II] λ12567 also presents the component due to the equatorial emission. Low density regions in the torus involving the central source allow a beam of radiation to escape to large radii and thereby excite the gas contained in the equatorial disc. The best example of this effect was detected in the Doppler tomography of the He I λ10830 line, that revealed an intrinsic emission component which reaches distances larger than the aparent boundary of the NW lobe and was firstly mapped in this dissertation.

APA, Harvard, Vancouver, ISO, and other styles

42

Filho, Olavo de Souza Pinto. "Cadernos nagô. A antropologia reversa do Alapini Paulo Braz Ifamuide." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/8/8134/tde-16062015-124158/.

Full text

Abstract:

Esta dissertação tem como tema central a composição dos versos de Ifá escritos pelo Alapini Paulo Braz Ifamuiyde. Ifá é um sistema oracular de origem iorubana, que é baseado no manejo de dezesseis caroços de dendê, para obter uma combinação entre um conjunto de 256 signos gráficos denominados odus (destinos), cada odu contém uma quantidade de versos ou recados que compõem seus significados. Minha incursão etnográfica atenta-se sobre os modos como Pai Paulo convencionaliza sua experiência com Ifá a partir da escrita em seus cadernos dos recados de Ifá, a fim de ressaltar particularidades e diferenças significativas entre essa prática oracular e outras práticas conhecidas no nagô. A dissertação busca fornecer uma descrição detalhada das variações e inovações rituais do jogo de Ifá, bem como as interações do dia a dia dos seus praticantes. Para tanto, tem como escopo mapear as relações estabelecidas pelo jogo entre diferentes domínios rituais do candomblé, centrados nos vereditos de Ifá que são dele indissociáveis, como feitura de santo, culto aos ancestrais, oferendas, sacrifícios , suscitando questões em diálogo, com temas já consagrados pela etnologia afro-brasileira, como transformação ritual, dom e iniciação, e transmissão de conhecimento e reversibilidade. This paper dissertation as its subject the Ifá verses composition written by Alipini Paulo Braz Ifamuiyde. Ifá is an oracular system of iorubana origin, which is based in the handling of sixteen caroços de dendês, to obtain a combination of 256 graphic signs called odus (destinies), each one containing a quantity of verses or messages that compose theirs significates. My ethnographic incursion attempts to the modes how Pai Paulo conventionalizes his experience with Ifá from the written in his Recados de Ifá notebook, in order to highlight particular and meaningful differences between this oracular practical and others practical known in nago. This work attempts to offer a detailed description of the ritual variations and innovations of the Ifa jogo, as such the interactions of the everyday life of its practitioners. For this purpose, the objective is mapping how relations established by the jogo between the different ritual domains of candomblé, centered in the Ifás verdicts which are inseparable from it, as such the saint feitura, ancestral cults, offerings, sacrifices -, raising questions in dialogue to themes already consagrated in afro-brazilian ethnology, as such ritual transformation, gift and initiation, and knowledge transmission and reversibility.

APA, Harvard, Vancouver, ISO, and other styles

43

Sequeira, Catarina Isabel Lopes. "Infeção por Leishmania spp./Leishmaniose em gatos na Península de Setúbal." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2021. http://hdl.handle.net/10400.5/21127.

Full text

Abstract:

Dissertação de Mestrado Integrado em Medicina Veterinária A leishmaniose é uma doença parasitária infeciosa zoonótica, causada por um protozoário do género Leishmania que é transmitido durante a refeição dos flebótomos fêmeas. Sabe-se que Leishmania infantum infeta carnívoros domésticos e selvagens, lagomorfos, roedores, entre outros animais, incluindo o Homem. Os gatos são naturalmente infetados e suscetíveis às espécies de Leishmania que afetam cães e humanos, e nos países da bacia do Mediterrâneo a maioria dos casos envolve L. infantum. A Leishmaniose Felina (LFel) é uma doença emergente, contudo, em Portugal, onde a Leishmaniose canina causada por L. infantum é endémica, só recentemente têm sido realizados alguns estudos em gatos. A presente dissertação teve como objetivos investigar a proporção de infeção por Leishmania spp./Leishmaniose em gatos na Península de Setúbal tendo as colheitas de sangue sido realizadas em gatos observados no Hospital Veterinário Principal Dra. Cristina Alves, na Charneca da Caparica. No Laboratório de Parasitologia e Doenças Parasitárias da FMV-ULisboa foram analisadas amostras de soro para deteção de anticorpos anti-Leishmania pela técnica de imunofluorescência indireta e observados esfregaços de sangue para deteção de hemoparasitas. Os resultados obtidos foram associados à história pregressa dos animais, aos sinais clínicos e à análise das respostas obtidas após realização de questionários pelos tutores/cuidadores dos gatos. Num total de 34 gatos, a proporção de animais com anticorpos anti-Leishmania spp. foi de 53% (limiar de positividade 1:40) e de 32,4% (limiar de positividade 1:80). Relativamente à presença de outros hemoparasitas, verificou-se que 65% dos gatos estavam infetados com Mycoplasma spp., dos quais 8 eram seropositivos a Leishmania spp. Foi ainda detetada, através de técnicas moleculares e de sequenciação, a presença de Hepatozoon felis num gato. Dos animais com anticorpos anti-Leishmania spp., 54,5% eram fêmeas e a média de idade dos gatos positivos foi de 7 anos. Os resultados obtidos permitiram um melhor conhecimento desta infeção/doença em gatos na Península de Setúbal. Salienta-se ser fundamental que os veterinários que atuem em áreas endémicas estejam cientes da suscetibilidade dos gatos à infeção por L. infantum/LFel, de modo a incluírem-nas no diagnóstico diferencial e a proporem medidas preventivas alertando os tutores sobre a importância desta prevenção. ABSTRACT - Leishmaniosis is a zoonotic infectious parasitic disease, caused by a protozoan of the genus Leishmania that is transmitted during the meal of female sandflies. Leishmania infantum is known to infect domestic and wild carnivores as well as lagomorphs and rodents, among other animals, including Man. Cats are naturally infected and susceptible to the same species of Leishmania that affect dogs and humans. In the countries of the Mediterranean basin most cases involve L. infantum. Feline Leishmaniosis (FelL) is an emerging disease, however, in Portugal, an endemic country for canine leishmaniosis caused by L. infantum, only recently studies have been carried out on Leishmania infection/FelL. The present dissertation aimed to investigate the proportion of Leishmania spp infection/ Leishmaniosis in cats in the Setúbal Peninsula and blood samples were collected from these animals observed at the Veterinary Hospital Principal Dra. Cristina Alves, in Charneca da Caparica. At the Laboratory of Parasitology and Parasitic Diseases, FMV-ULisboa, serum samples were analyzed for the detection of anti-Leishmania antibodies using the indirect immunofluorescence technique and stained blood smears were observed for the detection of hemoparasites. The obtained results were associated with the history of the animals, the clinical signs and the analysis of the responses obtained after the completion of questionnaires by the cat's guardians/caregivers. In a total of 34 cats, the proportion of antibodies anti-Leishmania spp. was 53% (cut-off 1:40) and 32.4% (cut-off 1:80). Regarding the presence of other hemoparasites, it was found that 65% of cats were infected with Mycoplasma spp., of which 8 were seropositive to Leishmania spp. Furthermore, it was possible to detect, through molecular techniques followed by sequencing, the presence of Hepatozoon felis in a cat. Of the animals positive to Leishmania spp. 54.5% were females and the average age of the positive cats was 7 years. The results obtained allowed a better knowledge of this infection/disease in cats in the Setúbal Peninsula. It should be emphasized that it is essential that veterinarians who work in endemic areas be aware of the susceptibility of cats to infection by L. infantum/FelL, in order to include them in the differential diagnosis list and to recommend preventive measures alerting tutors about the importance of this prevention. N/A

APA, Harvard, Vancouver, ISO, and other styles

44

Abdulhamed, Bilal Khudhur Abdulhammed. "Digital Instantaneous Frequency Measurement Receiver for Fine Frequency and High Sensitivity." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1559548084463134.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Edlund, Andreas. "Optimerad Samgranskning : En studie om samverkan mellan ArchiCAD och Solibri." Thesis, Uppsala universitet, Institutionen för teknikvetenskaper, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-188832.

Full text

Abstract:

Idag är det vanligt inom byggbranschen att så fort ett beslut är taget om att en byggnad ska uppföras, ska den blir klar snarast som möjligt. Detta kräver i sin tur att projekteringen ska utföras på kortast möjliga tid utan att fel uppstår, så själva bygget kan påbörjas. Samordningseffektiviseringen ska undersökas genom att författaren granskar hur en modell ska vara uppbyggd i ett CAD-program för att den ska kunna exporteras till ett samordningsprogram, där byggnadens ritningar granskas. Examensarbetet utfördes på uppdraget av företaget METOD arkitekter i Uppsala i slutet av den treåriga högskoleingenjörsutbildningen inom byggteknik. Syftet med detta projekt var att analysera en samverkan mellan CAD-programmet ArchiCAD och samordningsprogrammet Solibri. Detta för att på ett effektivare sätt kunna granska modellen i samordningsprogrammet och uppnå en optimal 3D-samordning. För att kunna genomföra studien gjordes en litteraturstudie, en observationsstudie, intervjuer med olika discipliner, inlärning av programmen samt en testprocess. Denna testprocess innebar att författaren ritade upp modeller i ArchiCAD och exporterade dessa till Solibri, detta för att kontrollera om modellerna överensstämde mellan programmen. Resultatet av examensarbetet visar att det finns möjligheter att kunna utveckla projekteringen och samordningen i 3D för att få en optimal och effektiv samordningsmodell. De flesta discipliner använder sig av programvaror som stödjer IFC-format, vilket innebär att modellerna kan öppnas i andra CAD-program. Detta skulle innebära att modellen skulle gå att kvalitétsäkra innan den blir till ritningar, och därmed minska antalet felaktigheter på byggarbetsplatsen. Nowadaysis it commonin the construction industrythat oncea decisionis made that a building willbe constructed, it should be done as soonas possible.Thisrequiresthatthe planningshould be performedin the shortest possible timewithoutany fault,so that the actual constructioncan begin.Coordinationeffectivenessis testedby the author who examineshow a modelmustbe designedin a CAD-programin order to be exported to a coordination program, wherethe buildingplanswill be examined. The thesiswas conducted on behalf of the companyMETOD arkitekterin Uppsalaas the final part ofthe three-yearbachelorprogramin construction engineering. The purpose ofthis project was toanalyzethe interaction ofCAD softwareArchiCAD andcoordinationprogramSolibri. Therefore,investigate themodel incoordinatingthe program andachieve an optimal3-D coordination. To perform this study the author made a literature study, an observational study, interviews with various disciplines, training and a test process in the programs. Thistesting processmeans thatthe authordrewupmodelsin ArchiCADand exportedthemtoSolibri, in order to checkwhether the modelswere consistentbetween the programs. The resultof the thesisshows that there areopportunities to improveplanningand coordinationin 3D toobtainan optimal and efficientcoordination model. Mostdisciplines usesoftware thatsupports theIFC format, which means that the modelscan be opened inother CAD programs. This would meanthat the modelwould betoensurequalitybefore it getsto thedrawings, and by that reducethe number of errorsat the construction site.

APA, Harvard, Vancouver, ISO, and other styles

46

Anagnostopoulos, Ioannis. "Generating As-Is BIMs of existing buildings : from planar segments to spaces." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/281699.

Full text

Abstract:

As-Is Building Information Models aid in the management, maintenance and renovation of existing buildings. However, most existing buildings do not have an accurate geometric depiction of their As-Is conditions. The process of generating As-Is models of existing structures involves practitioners, who manually convert Point Cloud Data (PCD) into semantically meaningful 3D models. This process requires a significant amount of manual effort and time. Previous research has been able to model objects by segmenting the point clouds into planes and classifying each one separately into classes, such as walls, floors and ceilings; this is insufficient for modelling, as BIM objects are comprised of multiple planes that form volumetric objects. This thesis introduces a novel method that focuses on the geometric creation of As-Is BIMs with enriched information. It tackles the problem by detecting objects, modelling them and enriching the model with spaces and object adjacencies from PCD. The first step of the proposed method detects objects by exploiting the relationships the segments should satisfy to be grouped into one object. It further proposes a method for detecting slabs with variations in height by finding local maxima in the point density. The second step models the geometry of walls and finally enriches the model with closed spaces encoded in the Industry Foundation Classes (IFC) standard. The method uses the point cloud density of detected walls to determine their width by projecting the wall into two directions and finding the edges with the highest density. It identifies adjacent walls by finding gaps or intersections between walls and exploits walls adjacency for correcting their boundaries, creating an accurate 3D geometry of the model. Finally, the method detects closed spaces by using a shortest-path algorithm. The method was tested on three original PCD which represent office floors. The method detects objects of class walls, floors and ceilings in PCD with an accuracy of approximately 96%. The precision and recall for the room detection were found to be 100%.

APA, Harvard, Vancouver, ISO, and other styles

47

Sahota, Jaspal Peter. "Generative knowledge : a pragmatist logic of inquiry articulated by the classical Indian philosopher Bhaṭṭa Kumārila". Thesis, University of Sussex, 2015. http://sro.sussex.ac.uk/id/eprint/54213/.

Full text

Abstract:

This thesis investigates the svataḥ-prāmāṇyam doctrine of the 7th century Indian philosopher Bhaṭṭa Kumārila, based on an analysis of this doctrine as presented in the Bṛhaṭ-ṭīkā and in the Śloka-vārttika. The original contribution of this thesis consists in a novel interpretation of Kumārila's claim which diverges from the interpretations of the classical Indian commentators as well as those of recent scholarship by John Taber and Dan Arnold. Rather than a phenomenological or Reidean epistemology, this research argues that Kumārila provides a normative epistemology. In contrast to the interpretation of Dan Arnold, which roots justification and truth in the phenomenological fact of mere awareness which is undefeated, it is argued here that Kumārila articulates a normative process which mandates the believer to strengthen her beliefs through a purposive and goal-oriented process. The thesis begins with a consideration of the notion of svabhāva, to which Kumārila appeals, making a dispositional essentialist reading of this term, as a real causal power or disposition which is the essence of an entity conditional on its existence. It is then argued that Kumārila's claim concerns the manifestation of a competence. The operational dichotomy between pramāṇa and non-pramāṇa is compared to that between Good and Bad Cases in epistemological disjunctivism. It is shown that Kumārila articulates a belief protocol by analogy with normative processes in generative grammar and in legal and ritual interpretation. An antifoundationalist defence of this protocol and its applicability to the case of beliefs formed from Vedic testimony is provided. It is suggested that Kumārila's claim engages more closely with Sosa's notion of aptness than with any notion of justification.

APA, Harvard, Vancouver, ISO, and other styles

48

Fitzharris, Margaret. "Characterizing and minimizing nonlinearities responsible for intermodulation distortion in high speed and high power photodiodes." Thesis, Georgia Institute of Technology, 2016. http://hdl.handle.net/1853/55069.

Full text

Abstract:

A physics-based model incorporating the UTC (uni-traveling carrier) photodiode (PD) in the limit of weak nonlinearity was used in order to characterize the effects of nonlinearity on high speed and high power photodiodes. The combined influences of a) optical illumination, b) photocurrent, and c) interaction of the photodiode with an external circuit, were incorporated into three equations which described the phasor dynamics of the photodiode, which could be used to approximate the diode voltage, the depletion region thickness, and the electric field at the beginning of the depletion region by the Newton-Raphson Method. Then a frequency response plot as well as a third-order intermodulation distortion (IMD3) plot were obtained in order to evaluate the effects of nonlinearity on the photodiode. The third-order intercept point (IP3) was determined to be approximately 27.5 dB, illustrating its slight nonlinearity. For both the frequency and the IMD3 plots, it was shown that modulation bandwidth is predominantly RC-limited and that the stated assumptions were true: that the average electron transit time through the depletion region is expected to be significantly smaller than the period of the optical stimulus. Finally, nonlinearity was minimized by compensating the heavy loading and space charge effects on junction capacitance, and a surface plot was obtained demonstrating this behavior.

APA, Harvard, Vancouver, ISO, and other styles

49

Martinez, Blancas Fernando. "Jefatura de oficinas de seguimiento y análisis en la 02 junta distrital ejecutiva del Insituto Federal Electoral en Baja California Sur: Sistema de Captura de Información Electoral." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2015. http://hdl.handle.net/20.500.11799/59177.

Full text

Abstract:

El proyecto propuesto por el IFE consideró el suministro de servicios de búsqueda, actualización y comparación multibiométrica, así como la integración de los servicios para la interoperabilidad de la solución, con el Sistema Integral de Información del Registro Federal de Electores (SIIRFE). Los productos que el IFE se planteó obtener mediante la contratación de estos servicios es el mejoramiento de la calidad del Padrón Electoral y los productos electorales, mediante la identificación y autenticación de los datos de los ciudadanos al momento que recogen su Credencial para Votar con fotografía en el Módulo de Atención Ciudadana; el mejoramiento de la prevención de fraudes de identidad y la optimización de las actividades de depuración del Padrón Electoral, así como también el aseguramiento de la continuidad de la Solución Integral de Identificación Multibiométrica con que contaba el Instituto.

APA, Harvard, Vancouver, ISO, and other styles

50

Kazan, Ana Lúcia. "Perceptions of innovative farmers of Ohio on extension as a source of information on sustainable agriculture." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1102360659.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Dissertations / Theses on the topic 'IF3'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles