Relevant bibliographies by topics / IFN-gamma immunomodulation

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  1. Journal articles
  2. Dissertations / Theses

Academic literature on the topic 'IFN-gamma immunomodulation'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "IFN-gamma immunomodulation"

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ten Hagen, Timo L. M., Wim van Vianen, Huub F. J. Savelkoul, Hubertine Heremans, Wim A. Buurman, and Irma A. J. M. Bakker-Woudenberg. "Involvement of T Cells in Enhanced Resistance to Klebsiella pneumoniae Septicemia in Mice Treated with Liposome-Encapsulated Muramyl Tripeptide Phosphatidylethanolamine or Gamma Interferon." Infection and Immunity 66, no. 5 (1998): 1962–67. http://dx.doi.org/10.1128/iai.66.5.1962-1967.1998.

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ABSTRACT We have previously shown that prophylactic administration of the liposome-encapsulated immunomodulating agents muramyl tripeptide phosphatidylethanolamine (MTPPE) and gamma interferon (IFN-γ) results in strongly increased survival of mice from a normally lethal septicemia with Klebsiella pneumoniae. It was anticipated that the treatment acts on macrophages and nonspecifically augments host resistance to various infections. In the present study, we provide evidence for a key role for T cells in host defense potentiation by the liposomal immunomodulators toward K. pneumoniae septicemia.
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Zhou, Qing, Ruth A. Gault, Thomas R. Kozel, and William J. Murphy. "Immunomodulation with CD40 Stimulation and Interleukin-2 Protects Mice from Disseminated Cryptococcosis." Infection and Immunity 74, no. 4 (2006): 2161–68. http://dx.doi.org/10.1128/iai.74.4.2161-2168.2006.

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ABSTRACT Cryptococcus neoformans is a ubiquitous fungus that can cause life-threatening infections during immunosuppressive states such as AIDS and after bone marrow transplantation. In this study we investigated the antifungal efficacy of an agonist antibody to CD40, an important costimulator of immune function, in combination with interleukin 2 (IL-2) in a murine model of disseminated cryptococcosis. Only the combination of anti-CD40 and IL-2 significantly prolonged the survival time of infected mice. This protection was correlated with decreased yeast burdens in the brain and kidney. Increa
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Ely, P., PK Wallace, AL Givan, RF Graziano, PM Guyre, and MW Fanger. "Bispecific-armed, interferon gamma-primed macrophage-mediated phagocytosis of malignant non-Hodgkin's lymphoma." Blood 87, no. 9 (1996): 3813–21. http://dx.doi.org/10.1182/blood.v87.9.3813.bloodjournal8793813.

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To show that macrophages can be effectively targeted against malignant B cells, bispecific antibodies (BsAb) were constructed from two antibodies having specificity for the high-affinity Fc receptor for IgG (Fc gamma RI/CD64) and the B-cell differentiation antigens CD19 and CD37. Using a flow cytometry-based assay and confocal imaging, we show that these constructs mediated significant phagocytosis of B lymphocytes by macrophages that could be enhanced with interferon gamma (IFN gamma) and IFN gamma in combination with macrophage colony- stimulating factor. BsAb-dependent phagocytosis was trig
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Ozwara, Hastings, Jan A. M. Langermans, Clemens H. M. Kocken, et al. "Transfected Plasmodium knowlesi Produces Bioactive Host Gamma Interferon: a New Perspective for Modulating Immune Responses to Malaria Parasites." Infection and Immunity 71, no. 8 (2003): 4375–81. http://dx.doi.org/10.1128/iai.71.8.4375-4381.2003.

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ABSTRACT Transgenic pathogenic microorganisms expressing host cytokines such as gamma interferon (IFN-γ) have been shown to manipulate host-pathogen interaction, leading to immunomodulation and enhanced protection. Expression of host cytokines in malaria parasites offers the opportunity to investigate the potential of an immunomodulatory approach by generating immunopotentiated parasites. Using the primate malaria parasite Plasmodium knowlesi, we explored the conditions for expressing host cytokines in malaria parasites. P. knowlesi parasites transfected with DNA constructs for expressing rhes
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Pilione, Mylisa R., and Eric T. Harvill. "The Bordetella bronchiseptica Type III Secretion System Inhibits Gamma Interferon Production That Is Required for Efficient Antibody-Mediated Bacterial Clearance." Infection and Immunity 74, no. 2 (2006): 1043–49. http://dx.doi.org/10.1128/iai.74.2.1043-1049.2006.

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ABSTRACT Several species of pathogenic microorganisms have developed strategies to survive and persist in vital organs which are normally maintained as sterile by the generation of strong immune responses. Here, we report an immunomodulation involving the Bordetella bronchiseptica type III secretion system (TTSS) which contributes to bacterial survival in the lower respiratory tract of the host. The prolonged persistence of B. bronchiseptica that was observed in gamma interferon (IFN-γ)−/− mice indicates that the efficient clearance of bacteria from the lower respiratory tract requires not onl
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Klyueva, S. N., A. Yu Goncharova, A. L. Kravtsov, and S. A. Bugorkova. "Influence of immunomodulation on intracellular cytokine expression by spleen T-helpers of mice immunized by Yersinia pestis EV NIIEG." Journal of microbiology, epidemiology and immunobiology 98, no. 2 (2021): 156–62. http://dx.doi.org/10.36233/0372-9311-28.

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Aim. To characterize the intracellular expression of cytokines by spleen T-helpers and the spontaneous production of cytokines in the blood of BALB/c mice immunized with Yersinia pestis EV NIIEG against the background of immunomodulation.Materials and methods. Intracellular expression of CD4+IFN-γ+, CD4+IL-4+, CD4+IL-17+ was determined in mice spleen cell suspensions by flow cytometry, IFN-γ and IL-10 were measured in ELISA in blood supernatants on day 3 and day 21 after the immunization with Y. pestis EV against the background of immunomodulation. On day 21 after the immunization animals were
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Graham, Simon P., Alexander J. Trees, Robert A. Collins, et al. "Down-Regulated Lymphoproliferation Coincides with Parasite Maturation and with the Collapse of Both Gamma Interferon and Interleukin-4 Responses in a Bovine Model of Onchocerciasis." Infection and Immunity 69, no. 7 (2001): 4313–19. http://dx.doi.org/10.1128/iai.69.7.4313-4319.2001.

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ABSTRACT Onchocerciasis is a debilitating parasitic infection caused by the filarial nematode Onchocerca volvulus. Infections are chronic, and persistence of the parasites for several years argues for highly adapted mechanisms of immune evasion. Due to the restricted host repertoire of O. volvulus, we have used the cattle parasite Onchocerca ochengi to investigate the nature of immunomodulation underpinning these long-term infections. Cattle were infected with a single inoculation of 350 infective-stage larvae under laboratory conditions (n = 6). Intradermal nodules containing immature adult w
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Harker, James A., Debbie C. P. Lee, Yuko Yamaguchi, et al. "Delivery of Cytokines by Recombinant Virus in Early Life Alters the Immune Response to Adult Lung Infection." Journal of Virology 84, no. 10 (2010): 5294–302. http://dx.doi.org/10.1128/jvi.02503-09.

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ABSTRACT Respiratory syncytial virus (RSV) is the main cause of bronchiolitis, the major cause of hospitalization of infants. An ideal RSV vaccine would be effective for neonates, but the immune responses of infants differ markedly from those of adults, often showing a bias toward T-helper 2 (Th2) responses and reduced gamma interferon (IFN-γ) production. We previously developed recombinant RSV vectors expressing IFN-γ and interleukin-4 (IL-4) that allow us to explore the role of these key Th1 and Th2 cytokines during infection. The aim of the current study was to explore whether an immunomodu
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Taghizadeh, Somayyeh, Tahereh Falsafi, Rouha Kasra Kermanshahi, and Reihaneh Ramezani. "Antagonistic and Immunomodulant Effects of Two Probiotic Strains of Lactobacillus on Clinical Strains of Helicobacter pylori." Galen Medical Journal 9 (October 14, 2020): 1794. http://dx.doi.org/10.31661/gmj.v9i0.1794.

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Background: The present study aimed to evaluate the in vitro and in situ antagonistic effects of Lactobacillus probiotic strains on clinical strains of Helicobacter pylori . Also to investigate their immunomodulation effects on a macrophage cell model. Materials and Methods: Anti-microbial effects of probiotic lactobacilli against H. pylori was assessed using the well and disk diffusion methods. Effects of lactobacilli probiotics strains, as well as their cell-free supernatant on adhesion of H. pylori to MKN-45 gastric epithelial cells, were examined in their presence and absence. Immunomodula
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Forte, Giusi Irma, Letizia Scola, Gabriella Misiano, et al. "Relevance of Gamma Interferon, Tumor Necrosis Factor Alpha, and Interleukin-10 Gene Polymorphisms to Susceptibility to Mediterranean Spotted Fever." Clinical and Vaccine Immunology 16, no. 6 (2009): 811–15. http://dx.doi.org/10.1128/cvi.00121-09.

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ABSTRACT The acute phase of Mediterranean spotted fever (MSF) is characterized by dramatic changes in cytokine production patterns, clearly indicating their role in the immunomodulation of the response against the microorganism, and the differences in cytokine production seem to influence the extent and severity of the disease. In this study, the single nucleotide polymorphisms (SNPs) of tumor necrosis factor alpha (TNF-α) −308G/A (rs1800629) and interleukin-10 (IL-10) −1087G/A (rs1800896), −824C/T (rs1800871), and −597C/A (rs1800872) and the gamma interferon (IFN-γ) T/A SNP at position +874 (
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Dissertations / Theses on the topic "IFN-gamma immunomodulation"

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Žlabová, Anna. "Charakterizace vedlejší populace buněčné linie TRAMP-C2, myšího modelu karcinomu prostaty"." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-305775.

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Side population is a minor subpopulation (SP) of some cell lines, exporting staining dye Hoechst 33342 out of their cytoplasm. It is discussed as a possible source of "cancer stem cells", "tumour initiating cells" or "metastasis initiating cells". However, broad literature suggest, that stemness and other privileged properties of SP are very variable between different cell types, cell lines and stage of disease. Cell lines TRAMP are the only widely available murine models for testing of prostate cancer therapy. We noticed in literature a mention about existence of 1-2% of cells constituting si
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