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Journal articles on the topic 'IFN-gamma immunomodulation'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

ten Hagen, Timo L. M., Wim van Vianen, Huub F. J. Savelkoul, Hubertine Heremans, Wim A. Buurman, and Irma A. J. M. Bakker-Woudenberg. "Involvement of T Cells in Enhanced Resistance to Klebsiella pneumoniae Septicemia in Mice Treated with Liposome-Encapsulated Muramyl Tripeptide Phosphatidylethanolamine or Gamma Interferon." Infection and Immunity 66, no. 5 (1998): 1962–67. http://dx.doi.org/10.1128/iai.66.5.1962-1967.1998.

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ABSTRACT We have previously shown that prophylactic administration of the liposome-encapsulated immunomodulating agents muramyl tripeptide phosphatidylethanolamine (MTPPE) and gamma interferon (IFN-γ) results in strongly increased survival of mice from a normally lethal septicemia with Klebsiella pneumoniae. It was anticipated that the treatment acts on macrophages and nonspecifically augments host resistance to various infections. In the present study, we provide evidence for a key role for T cells in host defense potentiation by the liposomal immunomodulators toward K. pneumoniae septicemia.

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Zhou, Qing, Ruth A. Gault, Thomas R. Kozel, and William J. Murphy. "Immunomodulation with CD40 Stimulation and Interleukin-2 Protects Mice from Disseminated Cryptococcosis." Infection and Immunity 74, no. 4 (2006): 2161–68. http://dx.doi.org/10.1128/iai.74.4.2161-2168.2006.

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ABSTRACT Cryptococcus neoformans is a ubiquitous fungus that can cause life-threatening infections during immunosuppressive states such as AIDS and after bone marrow transplantation. In this study we investigated the antifungal efficacy of an agonist antibody to CD40, an important costimulator of immune function, in combination with interleukin 2 (IL-2) in a murine model of disseminated cryptococcosis. Only the combination of anti-CD40 and IL-2 significantly prolonged the survival time of infected mice. This protection was correlated with decreased yeast burdens in the brain and kidney. Increa

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Ely, P., PK Wallace, AL Givan, RF Graziano, PM Guyre, and MW Fanger. "Bispecific-armed, interferon gamma-primed macrophage-mediated phagocytosis of malignant non-Hodgkin's lymphoma." Blood 87, no. 9 (1996): 3813–21. http://dx.doi.org/10.1182/blood.v87.9.3813.bloodjournal8793813.

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To show that macrophages can be effectively targeted against malignant B cells, bispecific antibodies (BsAb) were constructed from two antibodies having specificity for the high-affinity Fc receptor for IgG (Fc gamma RI/CD64) and the B-cell differentiation antigens CD19 and CD37. Using a flow cytometry-based assay and confocal imaging, we show that these constructs mediated significant phagocytosis of B lymphocytes by macrophages that could be enhanced with interferon gamma (IFN gamma) and IFN gamma in combination with macrophage colony- stimulating factor. BsAb-dependent phagocytosis was trig

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Ozwara, Hastings, Jan A. M. Langermans, Clemens H. M. Kocken, et al. "Transfected Plasmodium knowlesi Produces Bioactive Host Gamma Interferon: a New Perspective for Modulating Immune Responses to Malaria Parasites." Infection and Immunity 71, no. 8 (2003): 4375–81. http://dx.doi.org/10.1128/iai.71.8.4375-4381.2003.

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ABSTRACT Transgenic pathogenic microorganisms expressing host cytokines such as gamma interferon (IFN-γ) have been shown to manipulate host-pathogen interaction, leading to immunomodulation and enhanced protection. Expression of host cytokines in malaria parasites offers the opportunity to investigate the potential of an immunomodulatory approach by generating immunopotentiated parasites. Using the primate malaria parasite Plasmodium knowlesi, we explored the conditions for expressing host cytokines in malaria parasites. P. knowlesi parasites transfected with DNA constructs for expressing rhes

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Pilione, Mylisa R., and Eric T. Harvill. "The Bordetella bronchiseptica Type III Secretion System Inhibits Gamma Interferon Production That Is Required for Efficient Antibody-Mediated Bacterial Clearance." Infection and Immunity 74, no. 2 (2006): 1043–49. http://dx.doi.org/10.1128/iai.74.2.1043-1049.2006.

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ABSTRACT Several species of pathogenic microorganisms have developed strategies to survive and persist in vital organs which are normally maintained as sterile by the generation of strong immune responses. Here, we report an immunomodulation involving the Bordetella bronchiseptica type III secretion system (TTSS) which contributes to bacterial survival in the lower respiratory tract of the host. The prolonged persistence of B. bronchiseptica that was observed in gamma interferon (IFN-γ)−/− mice indicates that the efficient clearance of bacteria from the lower respiratory tract requires not onl

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Klyueva, S. N., A. Yu Goncharova, A. L. Kravtsov, and S. A. Bugorkova. "Influence of immunomodulation on intracellular cytokine expression by spleen T-helpers of mice immunized by Yersinia pestis EV NIIEG." Journal of microbiology, epidemiology and immunobiology 98, no. 2 (2021): 156–62. http://dx.doi.org/10.36233/0372-9311-28.

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Aim. To characterize the intracellular expression of cytokines by spleen T-helpers and the spontaneous production of cytokines in the blood of BALB/c mice immunized with Yersinia pestis EV NIIEG against the background of immunomodulation.Materials and methods. Intracellular expression of CD4+IFN-γ+, CD4+IL-4+, CD4+IL-17+ was determined in mice spleen cell suspensions by flow cytometry, IFN-γ and IL-10 were measured in ELISA in blood supernatants on day 3 and day 21 after the immunization with Y. pestis EV against the background of immunomodulation. On day 21 after the immunization animals were

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Graham, Simon P., Alexander J. Trees, Robert A. Collins, et al. "Down-Regulated Lymphoproliferation Coincides with Parasite Maturation and with the Collapse of Both Gamma Interferon and Interleukin-4 Responses in a Bovine Model of Onchocerciasis." Infection and Immunity 69, no. 7 (2001): 4313–19. http://dx.doi.org/10.1128/iai.69.7.4313-4319.2001.

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ABSTRACT Onchocerciasis is a debilitating parasitic infection caused by the filarial nematode Onchocerca volvulus. Infections are chronic, and persistence of the parasites for several years argues for highly adapted mechanisms of immune evasion. Due to the restricted host repertoire of O. volvulus, we have used the cattle parasite Onchocerca ochengi to investigate the nature of immunomodulation underpinning these long-term infections. Cattle were infected with a single inoculation of 350 infective-stage larvae under laboratory conditions (n = 6). Intradermal nodules containing immature adult w

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Harker, James A., Debbie C. P. Lee, Yuko Yamaguchi, et al. "Delivery of Cytokines by Recombinant Virus in Early Life Alters the Immune Response to Adult Lung Infection." Journal of Virology 84, no. 10 (2010): 5294–302. http://dx.doi.org/10.1128/jvi.02503-09.

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ABSTRACT Respiratory syncytial virus (RSV) is the main cause of bronchiolitis, the major cause of hospitalization of infants. An ideal RSV vaccine would be effective for neonates, but the immune responses of infants differ markedly from those of adults, often showing a bias toward T-helper 2 (Th2) responses and reduced gamma interferon (IFN-γ) production. We previously developed recombinant RSV vectors expressing IFN-γ and interleukin-4 (IL-4) that allow us to explore the role of these key Th1 and Th2 cytokines during infection. The aim of the current study was to explore whether an immunomodu

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Taghizadeh, Somayyeh, Tahereh Falsafi, Rouha Kasra Kermanshahi, and Reihaneh Ramezani. "Antagonistic and Immunomodulant Effects of Two Probiotic Strains of Lactobacillus on Clinical Strains of Helicobacter pylori." Galen Medical Journal 9 (October 14, 2020): 1794. http://dx.doi.org/10.31661/gmj.v9i0.1794.

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Background: The present study aimed to evaluate the in vitro and in situ antagonistic effects of Lactobacillus probiotic strains on clinical strains of Helicobacter pylori . Also to investigate their immunomodulation effects on a macrophage cell model. Materials and Methods: Anti-microbial effects of probiotic lactobacilli against H. pylori was assessed using the well and disk diffusion methods. Effects of lactobacilli probiotics strains, as well as their cell-free supernatant on adhesion of H. pylori to MKN-45 gastric epithelial cells, were examined in their presence and absence. Immunomodula

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Forte, Giusi Irma, Letizia Scola, Gabriella Misiano, et al. "Relevance of Gamma Interferon, Tumor Necrosis Factor Alpha, and Interleukin-10 Gene Polymorphisms to Susceptibility to Mediterranean Spotted Fever." Clinical and Vaccine Immunology 16, no. 6 (2009): 811–15. http://dx.doi.org/10.1128/cvi.00121-09.

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ABSTRACT The acute phase of Mediterranean spotted fever (MSF) is characterized by dramatic changes in cytokine production patterns, clearly indicating their role in the immunomodulation of the response against the microorganism, and the differences in cytokine production seem to influence the extent and severity of the disease. In this study, the single nucleotide polymorphisms (SNPs) of tumor necrosis factor alpha (TNF-α) −308G/A (rs1800629) and interleukin-10 (IL-10) −1087G/A (rs1800896), −824C/T (rs1800871), and −597C/A (rs1800872) and the gamma interferon (IFN-γ) T/A SNP at position +874 (

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Parker, April Keim, Wayne M. Yokoyama, John A. Corbett, Nanhai Chen, and R. Mark L. Buller. "Primary naïve and interleukin-2-activated natural killer cells do not support efficient ectromelia virus replication." Journal of General Virology 89, no. 3 (2008): 751–59. http://dx.doi.org/10.1099/vir.0.83205-0.

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Natural killer (NK) cells are known for their ability to lyse tumour cell targets. Studies of infections by a number of viruses, including poxviruses and herpesviruses, have demonstrated that NK cells are vital for recovery from these infections. Little is known of the ability of viruses to infect and complete a productive replication cycle within NK cells. Even less is known concerning the effect of infection on NK cell biology. This study investigated the ability of ectromelia virus (ECTV) to infect NK cells in vitro and in vivo. Following ECTV infection, NK cell gamma interferon (IFN-γ) pro

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Racila, Razvan George, Wolfgang Melchinger, Jürgen Finke та Reinhard E. Marks. "Everolimus Enhances Immunomodulation of Alloreative T Cells by Multipotent Stromal Cells Due to Transforming Growth Factor - β Dependent Mechanisms". Blood 116, № 21 (2010): 2545. http://dx.doi.org/10.1182/blood.v116.21.2545.2545.

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Abstract Abstract 2545 Steroid refractory Graft versus Host Disease (GvHD) is a serious complication following allogeneic haematopoietic stem cell transplantation (HCT). Recently, novel therapeutic strategies involving multipotent stromal cell (MSC) transfusions have shown promising clinical results. Nevertheless, little is known on the interaction between MSC and immunosuppressive agents currently used for GvHD treatment and prophylaxis. Here we investigated the effects of mammalian target of rapamycin (mTOR) and calcineurin inhibitors on MSC mediated allogeneic T cell suppression. Since both

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Wakabayashi, Hiroyuki, Natsuko Takakura, Koji Yamauchi, and Yoshitaka Tamura. "Modulation of Immunity-Related Gene Expression in Small Intestines of Mice by Oral Administration of Lactoferrin." Clinical and Vaccine Immunology 13, no. 2 (2006): 239–45. http://dx.doi.org/10.1128/cvi.13.2.239-245.2006.

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ABSTRACTOral administration of lactoferrin (LF), an antimicrobial and immunomodulatory protein, shows a protective effect against infectious diseases, possibly via immunomodulation of the host. Initially, we confirmed an immunomodulatory effect of LF by observing changes in the number of cells in the leukocyte subsets in the peripheral blood and spleens of mice 1 day after oral administration of LF. Then we developed a quantitative reverse transcription-PCR method for 20 immunity-related genes of antimicrobial proteins, pattern recognition receptors, cytokines, and lymphocyte mobilization-rela

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Banerjee, Antara, Manjarika De, and Nahid Ali. "Combination Therapy with Paromomycin-Associated Stearylamine-Bearing Liposomes Cures Experimental Visceral Leishmaniasis through Th1-Biased Immunomodulation." Antimicrobial Agents and Chemotherapy 55, no. 4 (2011): 1661–70. http://dx.doi.org/10.1128/aac.00524-10.

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ABSTRACTVisceral leishmaniasis (VL) caused by the parasiteLeishmania donovaniis a potentially fatal disease. Available limited drugs are toxic, require prolonged treatment duration, and are costly. A low-cost parenteral formulation of paromomycin sulfate (PM) has recently been approved for the treatment of VL. Monotherapy with PM runs the risk of development of resistance. Hence, efforts are needed to develop a combination therapy of PM with other drugs to shorten the duration of treatment and prolong the effective life of the drug. PM was formulated with leishmanicidal stearylamine (SA)-beari

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15

Datta, Kausik, Andrew Lees, and Liise-anne Pirofski. "Therapeutic Efficacy of a Conjugate Vaccine Containing a Peptide Mimotope of Cryptococcal Capsular Polysaccharide Glucuronoxylomannan." Clinical and Vaccine Immunology 15, no. 8 (2008): 1176–87. http://dx.doi.org/10.1128/cvi.00130-08.

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ABSTRACTVaccination with P13, a peptide mimotope of the cryptococcal capsular polysaccharide glucuronoxylomannan (GXM), has been shown to confer protection against a subsequent lethalCryptococcus neoformanschallenge. In this study, we sought to investigate whether P13-based vaccines could be effective in an already-established infection. To address this question, we developed a systemic chronic cryptococcal infection model. We vaccinated chronically infected mice with P13-protein conjugates and monitored their survival. Compared to the controls, the conjugates prolonged the survival of chronic

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Chan, Justin M., Ganive Bhinder, Ho Pan Sham, et al. "CD4+T Cells Drive Goblet Cell Depletion during Citrobacter rodentium Infection." Infection and Immunity 81, no. 12 (2013): 4649–58. http://dx.doi.org/10.1128/iai.00655-13.

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ABSTRACTBoth idiopathic and infectious forms of colitis disrupt normal intestinal epithelial cell (IEC) proliferation and differentiation, although the mechanisms involved remain unclear. Recently, we demonstrated that infection by the attaching and effacing murine pathogenCitrobacter rodentiumleads to a significant reduction in colonic goblet cell numbers (goblet cell depletion). This pathology depends on T and/or B cells, asRag1−/−mice do not suffer this depletion during infection, instead suffering high mortality rates. To address the immune mechanisms involved, we reconstitutedRag−/−mice w

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Corbishley, Alexander, Nur Indah Ahmad, Kirsty Hughes, et al. "Strain-Dependent Cellular Immune Responses in Cattle following Escherichia coli O157:H7 Colonization." Infection and Immunity 82, no. 12 (2014): 5117–31. http://dx.doi.org/10.1128/iai.02462-14.

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ABSTRACTEnterohemorrhagicEscherichia coli(EHEC) O157:H7 causes hemorrhagic diarrhea and potentially fatal renal failure in humans. Ruminants are considered to be the primary reservoir for human infection. Vaccines that reduce shedding in cattle are only partially protective, and their underlying protective mechanisms are unknown. Studies investigating the response of cattle to colonization generally focus on humoral immunity, leaving the role of cellular immunity unclear. To inform future vaccine development, we studied the cellular immune responses of cattle during EHEC O157:H7 colonization.

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Medina, Eva, Paola Paglia, Thomas Nikolaus, Astrid Müller, Michael Hensel, and Carlos A. Guzmán. "Pathogenicity Island 2 Mutants of Salmonella typhimurium Are Efficient Carriers for Heterologous Antigens and Enable Modulation of Immune Responses." Infection and Immunity 67, no. 3 (1999): 1093–99. http://dx.doi.org/10.1128/iai.67.3.1093-1099.1999.

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ABSTRACT The potential use as vaccine delivery system of Salmonella typhimurium strains harboring defined mutations in thesseC (HH104) and sseD (MvP101) genes, which encode putative effector proteins of the type III secretion system ofSalmonella pathogenicity island 2, was evaluated and compared with that of the well-characterized aroA mutant strain SL7207 by using β-galactosidase (β-Gal) as a model antigen. When orally administered to immune-competent or gamma interferon-deficient (IFN-γ−/−) BALB/c mice, both mutants were found to be highly attenuated (50% lethal dose, >109 bacteria). Both

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Steinberg, R. S., M. Lima, N. L. Gomes de Oliveira, et al. "Effect of intestinal colonisation by two Lactobacillus strains on the immune response of gnotobiotic mice." Beneficial Microbes 5, no. 4 (2014): 409–19. http://dx.doi.org/10.3920/bm2013.0075.

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The effect of intestinal colonisation on the immune system was investigated in germ-free mice monoassociated with Lactobacillus strains isolated from calf faeces. Single doses of Lactobacillus acidophilus L36 or Lactobacillus salivarius L38 were administered to germ-free mice by intragastric gavage. Ten days later, the mice were euthanised. Gene expression levels of interleukin 5 (IL-5), IL-6, IL-10, IL-12b, IL-17a, gamma interferon (IFN-γ), transforming growth factor beta 1 (TGF-β1), and tumour necrosis factor alpha (TNF-α) were quantified in segments of the small and large intestines by real

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Matusik, Pawel, Bartlomiej Guzik, Christian Weber, and Tomasz J. Guzik. "Do we know enough about the immune pathogenesis of acute coronary syndromes to improve clinical practice?" Thrombosis and Haemostasis 108, no. 09 (2012): 443–56. http://dx.doi.org/10.1160/th12-05-0341.

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SummaryMorbidities related to atherosclerosis, such as acute coronary syndromes (ACS) including unstable angina and myocardial infarction, remain leading causes of mortality. Unstable plaques are inflamed and infiltrated with macrophages and T lymphocytes. Activated dendritic cells interact with T cells, yielding predominantly Th1 responses involving interferon-gamma (IFN-γ) and tumour necrosis factor-alpha (TNF-α), while the role of interleukin 17 (IL-17) is questionable. The expansion of CD28nullCD4 or CD8 T cells as well as pattern recognition receptors activation (especially Toll-like rece

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Rofael, H. Z., R. M. Turkall, and M. S. Abdel-Rahman. "Effect of Ketamine on Cocaine-Induced Immunotoxicity in Rats." International Journal of Toxicology 22, no. 5 (2003): 343–58. http://dx.doi.org/10.1177/109158180302200503.

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The abuse of cocaine (COC) with ketamine (KET) is currently popular among young drug abusers and has been associated with increased risk of human immunodeficiency virus (HIV) infection. The effect of subacute exposure to COC and KET alone and in combination on the immune system was assessed in adult male Sprague-Dawley (SD) rats. To simulate the route and mode of human exposure, rats were treated with COC alone (5 mg/kg, IV), KET alone (100 mg/kg, PO) or KET followed immediately by COC (same doses and routes of administration) once-a-day for 7 consecutive days. Rats were sacrified 30 minutes f

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Oyaizu, N., TW McCloskey, S. Than, and S. Pahwa. "Inhibition of CD4 cross-linking-induced lymphocytes apoptosis by vesnarinone as a novel immunomodulating agent: vesnarinone inhibits Fas expression and apoptosis by blocking cytokine secretion." Blood 87, no. 6 (1996): 2361–68. http://dx.doi.org/10.1182/blood.v87.6.2361.bloodjournal8762361.

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Evidence is accumulating that T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals show accelerated cell death through apoptosis. We have recently demonstrated that the cross-linking of CD4 molecules (CD4XL) results in death of normal peripheral T cells through apoptosis and imbalanced cytokine secretion (ie, induction of tumor necrosis factor-alpha [TNF-alpha] and interferon-gamma [IFN-gamma] in the absence of interleukin-2 [IL-2] or IL-4 secretion). These upregulated cytokines (TNF-alpha/IFN-gamma) largely contributed to upregulation of the apoptosis-inducing cell su

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Tohyama, M., K. Kawakami, and A. Saito. "Anticryptococcal effect of amphotericin B is mediated through macrophage production of nitric oxide." Antimicrobial Agents and Chemotherapy 40, no. 8 (1996): 1919–23. http://dx.doi.org/10.1128/aac.40.8.1919.

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Amphotericin B (AmB) is a classical antifungal drug and one of the most effective antifungal drugs for the treatment of systemic fungal infection. It is also known to have various immunomodulating activities other than its direct antifungal effect. In the present study, we demonstrated that AmB augmented gamma interferon (IFN-gamma)-induced killing potentials of murine peritoneal macrophages against Cryptococcus neoformans in a dose-dependent manner. This effect was strongly blocked by NG-monomethyl-L-arginine, a competitive inhibitor of nitric oxide (NO) synthesis. In addition, AmB markedly a

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Gressler, VH, RE Weinkauff, WA Franklin, and HM Golomb. "Modulation of the expression of major histocompatibility antigens on splenic hairy cells--differential effect upon in vitro treatment with alpha-2b-interferon, gamma-interferon, and interleukin-2." Blood 72, no. 3 (1988): 1048–53. http://dx.doi.org/10.1182/blood.v72.3.1048.1048.

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Abstract The mechanism of action responsible for the beneficial effect of alpha- interferon (alpha-IFN) in patients with hairy cell leukemia (HCL) is still unknown. Direct antineoplastic and immunomodulating effects on both the host immune system and the hairy cells themselves have been implicated. To evaluate whether lymphokines have any regulatory effect on antigens of the major histocompatibility complex (MHC) on hairy cells and whether this corresponds to prognostic clinical parameters, we studied splenic hairy cells from ten previously untreated patients. The samples were incubated with r

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Gressler, VH, RE Weinkauff, WA Franklin, and HM Golomb. "Modulation of the expression of major histocompatibility antigens on splenic hairy cells--differential effect upon in vitro treatment with alpha-2b-interferon, gamma-interferon, and interleukin-2." Blood 72, no. 3 (1988): 1048–53. http://dx.doi.org/10.1182/blood.v72.3.1048.bloodjournal7231048.

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The mechanism of action responsible for the beneficial effect of alpha- interferon (alpha-IFN) in patients with hairy cell leukemia (HCL) is still unknown. Direct antineoplastic and immunomodulating effects on both the host immune system and the hairy cells themselves have been implicated. To evaluate whether lymphokines have any regulatory effect on antigens of the major histocompatibility complex (MHC) on hairy cells and whether this corresponds to prognostic clinical parameters, we studied splenic hairy cells from ten previously untreated patients. The samples were incubated with recombinan

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Akrom, Akrom, Titiek Hidayati, Sagiran Sagiran та Indrayanti Indrayanti. "Black Cumin Seeds Extract Increase Lymphocyte Activity in IFN-γ Secretion in Sprague Dawley Rat (SD) Induced by Dimethylbenzantracene". Indonesian Journal of Cancer Chemoprevention 10, № 3 (2019): 140. http://dx.doi.org/10.14499/indonesianjcanchemoprev10iss3pp140-148.

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Interferon-gamma (IFN-γ) is one of the central cytokines in the anti-carcinogenesis immune response. Black cumin seeds (BCS) have an active content of thymoquinone and unsaturated fatty acids with biological activity as immunomodulators. This study aimed to determine the effect of administration of BCS extract on IFN-γ secretion activity by DMBA-induced SD rat lymphocytes. In vivo experimental study on DMBA-induced SD rats, BCS extract was given with three doses for two weeks before being induced and five weeks during DMBA induction. IFN-γ levels in lymphocyte culture supernatants were determi

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Kozarski, Maja, Anita Klaus, and Miomir Niksic. "Influence of structural features on immunostimulating activity of glucans extracted from Agaricus blazei mushroom." Zbornik Matice srpske za prirodne nauke, no. 116 (2009): 225–33. http://dx.doi.org/10.2298/zmspn0916225k.

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High molecular weight b-D-glucans derived from Basidiomycetes cell walls are able to specifically activate cellular and humoral components of the host immune system. The aim of this paper was to examine immunomodulating activity of native, chemically and enzimatically modified glucans from Agaricus blazei mushroom and to determine which structural features are of primary importance for their stimulation referring to humane immune cells. The immunomodulating activities were tested in vitro, by stimulation of peripheral blood mononuclear cells (PBMCs) and measuring of interferon-gamma (IFN-g) pr

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Giguère, Steeve, Bruce N. Wilkie, and John F. Prescott. "Modulation of Cytokine Response of Pneumonic Foals by Virulent Rhodococcus equi." Infection and Immunity 67, no. 10 (1999): 5041–47. http://dx.doi.org/10.1128/iai.67.10.5041-5047.1999.

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ABSTRACT The ability of Rhodococcus equi to induce pneumonia in foals depends on the presence of an 85- to 90-kb plasmid. In this study, we evaluated whether plasmid-encoded products mediate virulence by modulating the cytokine response of foals. Foals infected intrabronchially with a virulence plasmid-containing strain of R. equi had similar gamma interferon (IFN-γ) and interleukin-12 (IL-12) p35 but significantly higher IL-1β, IL-10, IL-12 p40, and tumor necrosis factor alpha (TNF-α) mRNA expression in lung tissue compared to foals infected with the plasmid-cured derivative. IFN-γ mRNA expre

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Bedekar, Megha Kadam, Praveena Soman, Sajal Kole та ін. "Evaluation of interferon gamma (IFN-γ) of Labeo rohita as an immunomodulator: in vitro expression model". Aquaculture International 26, № 6 (2018): 1401–13. http://dx.doi.org/10.1007/s10499-018-0292-9.

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Prioult, Guénolée, Sophie Pecquet та Ismail Fliss. "Stimulation of Interleukin-10 Production by Acidic β-Lactoglobulin-Derived Peptides Hydrolyzed with Lactobacillus paracasei NCC2461 Peptidases". Clinical Diagnostic Laboratory Immunology 11, № 2 (2004): 266–71. http://dx.doi.org/10.1128/cdli.11.2.266-271.2004.

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ABSTRACT We have previously demonstrated that Lactobacillus paracasei NCC2461 may help to prevent cow's milk allergy in mice by inducing oral tolerance to β-lactoglobulin (BLG). To investigate the mechanisms involved in this beneficial effect, we examined the possibility that L. paracasei induces tolerance by hydrolyzing BLG-derived peptides and liberating peptides that stimulate interleukin-10 (IL-10) production. L. paracasei peptidases have been shown to hydrolyze tryptic-chymotryptic peptides from BLG, releasing numerous small peptides with immunomodulating properties. We have now shown tha

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Hines, Stephen A., Diana M. Stone, Melissa T. Hines, et al. "Clearance of Virulent but Not Avirulent Rhodococcus equi from the Lungs of Adult Horses Is Associated with Intracytoplasmic Gamma Interferon Production by CD4+ and CD8+ T Lymphocytes." Clinical Diagnostic Laboratory Immunology 10, no. 2 (2003): 208–15. http://dx.doi.org/10.1128/cdli.10.2.208-215.2003.

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ABSTRACT Rhodococcus equi is a gram-positive bacterium that infects alveolar macrophages and causes rhodococcal pneumonia in horses and humans. The virulence plasmid of R. equi appears to be required for both pathogenicity in the horse and the induction of protective immunity. An understanding of the mechanisms by which virulent R. equi circumvents protective host responses and by which bacteria are ultimately cleared is important for development of an effective vaccine. Six adult horses were challenged with either virulent R. equi or an avirulent, plasmid-cured derivative. By using a flow cyt

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Korten, Simone, Richard J. Anderson, Carolyn M. Hannan та ін. "Invariant Vα14 Chain NKT Cells Promote Plasmodium berghei Circumsporozoite Protein-Specific Gamma Interferon- and Tumor Necrosis Factor Alpha-Producing CD8+ T Cells in the Liver after Poxvirus Vaccination of Mice". Infection and Immunity 73, № 2 (2005): 849–58. http://dx.doi.org/10.1128/iai.73.2.849-858.2005.

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ABSTRACT Understanding the protective mechanism in the liver induced by recombinant vaccines against the pre-erythrocytic stages of malaria is important for vaccine development. Most studies in mice have focused on splenic and peripheral blood T cells and identified gamma interferon (IFN-γ)-producing CD8+ T cells as correlates of protection, which can be induced by prime-boost vaccination with recombinant poxviruses. Invariant natural killer T (Vα14iNKT) cells can also protect against liver stage malaria, when activated, and are abundant in the liver. Since poxviruses have nonspecific immunomo

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Ferlat, S., C. Bottex-Gauthier, M. Li, F. Picot, D. Vidal, and P. Potier. "Effect of a Synthetic Immunomodulator on the Regulation of Gamma Interferon and Interleukin-10 Production during Salmonella Sepsis in Itys Mice." International Journal of Immunopathology and Pharmacology 10, no. 3 (1997): 167–74. http://dx.doi.org/10.1177/039463209701000301.

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The present study examined the in vivo capacity of diHDA-glycerol, a new chemically defined compound that we synthesized, to enhance nonspecific resistance of Itys mice to a virulent Salmonella typhimurium challenge (>LD50). This compound derives from (E)-10 hydroxy-2 decenoic acid (10-HDA), a fatty acid isolated from Royal Jelly. Bacterial growth rate within the spleen, interferon-gamma (IFN-γ), interleukin-10 (IL-10), and nitric oxide (NO) levels were measured in splenocyte cultures from diHDA-glycerol-pretreated mice or saline infected controls, at various time intervals after infectious

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Saini, Sheetal, Harisankar Singha, Priyanka Siwach, and B. N. Tripathi. "Recombinant horse interleukin-4 and interleukin-10 induced a mixed inflammatory cytokine response in horse peripheral blood mononuclear cells." Veterinary World 12, no. 4 (2019): 496–503. http://dx.doi.org/10.14202/vetworld.2019.496-503.

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Background and Aim: Interleukin (IL)-4 and IL-10 activate plethora of immune cells and induce the humoral immune response. However, recombinant version of horse IL-4 and IL-10 has not been investigated to understand their immunomodulating activities. This study aimed to produce recombinant horse mature IL-4 and IL-10 in Escherichia coli. Immune-modulating activities of recombinant horse IL-4 and IL-10 were investigated in peripheral blood mononuclear cells (PBMCs). Materials and Methods: Equine PBMCs were stimulated with recombinant IL-4 and IL-10. A proliferation of PBMCs was measured by XTT

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Zhang, Jeffrey, Everett Henry, L. Harris Zhang, and Wanying Zhang. "600 In vitro anticancer and immunomodulatory activities of NBT-167, a dimer of resveratrol." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A635. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0600.

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BackgroundResveratrol (3,4’,5-trihydroxystilbene), a stilbenoid isolated from many species of plants, is widely known for its antioxidative, anti-inflammatory, immunomodulatory and anticancer activities. Recently, novel resveratrol oligomers have been isolated from various plants; their diverse structures are characterized by the polymerization of two or more resveratrol units. Little is known regarding the anticancer and immunomodulating activities of these oligomers. In this study, we designed in vitro models to compare resveratrol side by side with its natural dimer NBT-167 for their antica

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Darabi, Atifeh, Setareh Haghighat та Mehdi Mahdavi. "Immunopotentiotor Effect of α-Tocopherol on Cytokine Expression in the Lymphocytes in the Elderly People". Immunoregulation 3, № 2 (2021): 107–14. http://dx.doi.org/10.32598/immunoregulation.3.2.4.

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Background: Aging is associated with attenuation of immune responses. Studies show that old people are vulnerable to infectious diseases such as influenza. α-Tocopherol as an immunomodulator affects immune responses. In the present study, the effect of α-tocopherol, on lymphocyte responses i.e. interferon-gamma (IFN-γ), Tumor Necrosis Factor-alpha (TNF-α), and nuclear factor-κB (NF-κB) in elderly individuals was evaluated. Materials and Methods: Heparinized blood samples were prepared from 10 elderly individuals (n=10, age >80 years) as the experimental group and 10 young individuals (n= 10

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Nurliyani, Madarina Julia, Eni Harmayani, Muthi Ikawati, and Endang Baliarti. "Potency of Lactobacillus plantarum Dad-13 and Sweet Potato (Ipomoea batatas) Fiber as Immunomodulator in Rats Infected With Salmonella Typhimurium." Journal of Food Research 4, no. 3 (2015): 1. http://dx.doi.org/10.5539/jfr.v4n3p1.

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<p><em>Lactobacillus plantarum</em> Dad-13 that isolated from “dadih” (traditional Indonesian fermented milk) has been known as probiotic, while sweet potato fiber has been proven as an effective prebiotic. The objective of this study was to evaluate the potency of <em>Lactobacillus plantarum</em> Dad-13 and sweet potato fiber as immunomodulators in terms of intestinal secretory immunoglobulin A (sIgA) and splenocyte gamma-interferon (IFN-?). Sixty male Sprague Dawley rats (uninfected and infected) were divided into five groups: AIN-93, Indonesian children diet (I

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Kókai, Dávid, Dóra Paróczai, Dezső Peter Virok, et al. "Ambroxol Treatment Suppresses the Proliferation of Chlamydia pneumoniae in Murine Lungs." Microorganisms 9, no. 4 (2021): 880. http://dx.doi.org/10.3390/microorganisms9040880.

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Ambroxol (Ax) is used as a mucolytics in the treatment of respiratory tract infections. Ax, at a general dose for humans, does not alter Chlamydia pneumoniae growth in mice. Therefore, we aimed to investigate the potential anti-chlamydial effect of Ax at a concentration four timed higher than that used in human medicine. Mice were infected with C. pneumoniae and 5-mg/kg Ax was administered orally. The number of recoverable C. pneumoniae inclusion-forming units (IFUs) in Ax-treated mice was significantly lower than that in untreated mice. mRNA expression levels of several cytokines, including i

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Kanda, Tatsuo, Robert Steele, Ranjit Ray, and Ratna B. Ray. "Inhibition of Intrahepatic Gamma Interferon Production by Hepatitis C Virus Nonstructural Protein 5A in Transgenic Mice." Journal of Virology 83, no. 17 (2009): 8463–69. http://dx.doi.org/10.1128/jvi.00751-09.

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ABSTRACT Hepatitis C virus (HCV) utilizes strategies to suppress or evade the host immune response for establishment of persistent infection. We have shown previously that HCV nonstructural protein 5A (NS5A) impairs tumor necrosis factor alpha (TNF-α)-mediated apoptosis. In this study, we have examined the immunomodulatory role of HCV NS5A protein in transgenic mouse (NS5A-Tg) liver when mice were challenged with an unrelated hepatotropic adenovirus as a nonspecific stimulus. Hepatotropic adenovirus was introduced intravenously into NS5A-Tg mice and control mice, and virus clearance from liver

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Davis, Jessica P., Sarah Herby, Meghaan P. Walsh, et al. "Extracorporeal Photopheresis Diminishes Graft-Versus-Host-Disease and Modulates Dendritic Cell Cytokine Production." Blood 110, no. 11 (2007): 2177. http://dx.doi.org/10.1182/blood.v110.11.2177.2177.

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Abstract Background: Graft-versus-host disease (GVHD) remains one of the largest obstacles in allogeneic stem cell transplantation. Current therapies for GVHD generally involve systemic immunosuppression resulting in increased risk of infection and relapse. Extracorporeal Photopheresis (ECP) is an emerging therapy for chronic GVHD that offers the potential of selective immunomodulation. In ECP, patient leukocytes are treated with 8-methoxypsoralen (8-MOP) and UVA light, causing them to undergo apoptosis, and are re-infused into the patient. Because ECP has been studied mostly in the clinical s

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Dulya, M. S., V. N. Karkischenko, D. V. Khvostov, R. A. Ageldinov, and N. N. Karkischenko. "CYTOKINE PROFILE OF LABORATORY INBRED AND TRANSGENIC MICE IN THE EVALUATION OF THE IMMUNOLOGICAL STATUS AND SEARCH FOR NEW PHARMACOLOGICAL REGULATORS." Biomeditsina, no. 2 (July 1, 2019): 54–62. http://dx.doi.org/10.33647/2074-5982-15-2-54-62.

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This article presents the results of studies aimed at investigating the cytokine profile of laboratory mice, including novel data on the cytokine status of transgenic mice NAT1hom and NAT2hom. The investigation of cytokines in the blood serum of laboratory animals was carried out using multiplex xMAP-analysis on magnetic particles. For mice of inbred lines C57BL/6 and Balb/c, data is presented with respectto changes in the quantitative content of cytokines in the blood plasma after a single injection of the Polymuramyl and Tacrolimus drugs. Effects of the Tacrolimus immunosuppressant and the P

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Emori, Yutaka, Tamako Ikeda, Takashi Ohashi, et al. "Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages." Journal of General Virology 85, no. 9 (2004): 2603–13. http://dx.doi.org/10.1099/vir.0.80046-0.

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Z-100 is an arabinomannan extracted from Mycobacterium tuberculosis that has various immunomodulatory activities, such as the induction of interleukin 12, interferon gamma (IFN-γ) and β-chemokines. The effects of Z-100 on human immunodeficiency virus type 1 (HIV-1) replication in human monocyte-derived macrophages (MDMs) are investigated in this paper. In MDMs, Z-100 markedly suppressed the replication of not only macrophage-tropic (M-tropic) HIV-1 strain (HIV-1JR-CSF), but also HIV-1 pseudotypes that possessed amphotropic Moloney murine leukemia virus or vesicular stomatitis virus G envelopes

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Chaudhary, Rajesh, Ajay Amit, Anupam Yadav та ін. "Immunomodulation in Human Dendritic Cells Leads to Induction of Interferon-Gamma Production byLeishmania donovaniDerived KMP-11 Antigen via Activation of NF-κB in Indian Kala-Azar Patients". BioMed Research International 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/947606.

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Dendritic cells (DCs) and macrophages (MΦs) are well-known antigen presenting cells with an ability to produce IL-12 which indicates that they have potential of directing acquired immunity toward a Th1-biased response. The aim of this study was to examine the effect ofLeishmaniaspecific KMP-11 antigen through comparison of immune responses after presentation by DCs and MΦs to T cells in Indian patients with VL. Patients with DCS and MΦs were directed against a purifiedLeishmania donovaniantigen (KMP-11) and phytohaemagglutinin (PHA). The cytokines (IL-12, IL-10, and TGF-β) producing abilities

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Liles, Darla K., Heather Brody, Juan Alvarez Posada, Karim Hebishi, and John Thiele. "Interferon Gamma, a Link between Hemophagocytic Lymphohistiocytosis and Dengue Fever Virus: A Literature Review of a Shared Inflammatory Pathway Resulting in Cytopenias and Potential Future Treatment Directions." Blood 134, Supplement_1 (2019): 4869. http://dx.doi.org/10.1182/blood-2019-126124.

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Our patient was an elderly female, previously healthy, who presented with fever, anemia, thrombocytopenia, and enlarged spleen. Her complaints were progressive over the course of two months. She was treated with antibiotics with no improvement. Underlying lymphoproliferative disorder was suspected, and a bone marrow biopsy and aspiration was completed. While there was no evidence for lymphoproliferative disorder, there was hemophagocytosis. Further evaluation revealed ferritin 1,151 ng/mL, soluble IL2 receptor 32,186 u/mL, and natural killer activity was low. She was diagnosed with secondary h

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Kim, Youn, Michael Girardi, Madeline Duvic, et al. "TLR9 Agonist Immunomodulator Treatment of Cutaneous T-Cell Lymphoma (CTCL) with CPG7909." Blood 104, no. 11 (2004): 743. http://dx.doi.org/10.1182/blood.v104.11.743.743.

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Abstract CPG 7909 belongs to a new class of chemically defined CpG immunomodulators that target dendritic cell TLR9 receptors inducing IL-12, IFN-gamma, and NK cell function. The rate and durability of response to CPG 7909 was investigated in refractory patients with recurrent or advanced CTCL, who had failed one or more systemic therapies. Dose escalation with weekly sc dosing of patients at 0.08, 0.16, 0.24, or 0.28 mg/kg (3 patients/cohort) for 24 weeks is nearing completion. Additional patients continue to receive treatment at 0.32 (4 patients) or 0.36 mg/kg (12 patients). Clinical respons

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Erawati, Meira, Nyoman Suci Widyastiti, Tri Indah Winarni, and Edi Dharmana. "beta-Glucan Increases IFN-gamma and IL-12 Production of Peripheral Blood Mononuclear Cells with/without Induction of Mycobacterium tuberculosis Wild-type/Mutant DNA." Indonesian Biomedical Journal 11, no. 2 (2019): 200–4. http://dx.doi.org/10.18585/inabj.v11i2.688.

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BACKGROUND: In tuberculosis infections, the immune system is weakened and cannot produce enough cytokines to against the infection. b-glucan is a potent immunomodulator that induces cytokine production in various bacterial infections. This study aimed to determine the effects of b-glucan on the production of interferon (IFN)-γ and interleukin (IL)-12 in peripheral blood mononuclear cells (PBMCs) induced by Mycobacterium tuberculosis DNA.METHODS: PBMCs were isolated from 11 healthy subjects. PBMCs were treated with/without 5 μg/mL b-glucan and M. tuberculosis rpoB wild-type or mutant DNA. The p

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Smyk, Daniel S., Athanasios Mavropoulos, Giorgina Mieli-Vergani, Diego Vergani, Marco Lenzi, and Dimitrios P. Bogdanos. "The Role of Invariant NKT in Autoimmune Liver Disease: Can Vitamin D Act as an Immunomodulator?" Canadian Journal of Gastroenterology and Hepatology 2018 (June 26, 2018): 1–14. http://dx.doi.org/10.1155/2018/8197937.

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Natural killer T (NKT) cells are a distinct lineage of T cells which express both the T cell receptor (TCR) and natural killer (NK) cell markers. Invariant NKT (iNKT) cells bear an invariant TCR and recognize a small variety of glycolipid antigens presented by CD1d (nonclassical MHC-I). CD1d-restricted iNKT cells are regulators of immune responses and produce cytokines that may be proinflammatory (such as interferon-gamma (IFN-γ)) or anti-inflammatory (such as IL-4). iNKT cells also appear to play a role in B cell regulation and antibody production. Alpha-galactosylceramide (α-GalCer), a deriv

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Huang, Haibin, Gary R. Ostroff, Chrono K. Lee, Jennifer P. Wang, Charles A. Specht та Stuart M. Levitz. "Distinct Patterns of Dendritic Cell Cytokine Release Stimulated by Fungal β-Glucans and Toll-Like Receptor Agonists". Infection and Immunity 77, № 5 (2009): 1774–81. http://dx.doi.org/10.1128/iai.00086-09.

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ABSTRACT β-Glucans derived from fungal cell walls have potential uses as immunomodulating agents and vaccine adjuvants. Yeast glucan particles (YGPs) are highly purified Saccharomyces cerevisiae cell walls composed of β1,6-branched β1,3-d-glucan and free of mannans. YGPs stimulated secretion of the proinflammatory cytokine tumor necrosis factor alpha (TNF-α) in wild-type murine bone marrow-derived myeloid dendritic cells (BMDCs) but did not stimulate interleukin-12p70 (IL-12p70) production. A purified soluble β1,6-branched β1,3-d-glucan, scleroglucan, also stimulated TNF-α in BMDCs. These two

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Moisan, Jacques, Wojciech Wojciechowski, Claudine Guilbault, et al. "Clearance of Infection with Mycobacterium bovis BCG in Mice Is Enhanced by Treatment with S28463 (R-848), and Its Efficiency Depends on Expression of Wild-Type Nramp1 (Resistance Allele)." Antimicrobial Agents and Chemotherapy 45, no. 11 (2001): 3059–64. http://dx.doi.org/10.1128/aac.45.11.3059-3064.2001.

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ABSTRACT The mouse bcg host resistance gene is known to control the activation of host macrophages for killing of intracellular parasites like Leishmania donovani as well as intracellular bacteria, including Mycobacterium bovisBCG and Salmonella enterica serovar Typhimurium. TheNramp1 gene has been mapped to this locus and affects the efficiency of macrophage activation. It has been shown that imidazoquinoline compounds, including S28463, are able to improve the clearance of a number of intracellular pathogens such as herpes simplex virus 2, human papillomavirus, and Leishmania. The goal of th

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Zhou, Jia, Mengyao Hu, Jie Li, et al. "Mannan-Binding Lectin Regulates Inflammatory Cytokine Production, Proliferation, and Cytotoxicity of Human Peripheral Natural Killer Cells." Mediators of Inflammation 2019 (December 13, 2019): 1–12. http://dx.doi.org/10.1155/2019/6738286.

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Natural killer (NK) cells represent the founding members of innate lymphoid cells (ILC) and play critical roles in inflammation and the immune response. NK cell effector functions are regulated and fine-tuned by various immune modulators. Mannan (or mannose)-binding lectin (MBL), a soluble C-type lectin, is traditionally recognized as an initiator of the complement pathway. Recently, it is also considered as an immunomodulator by its interaction with kinds of immune cells. However, the effect of MBL on NK cell function remains unexplored. In this study, we found that human plasma MBL could int

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