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Journal articles on the topic 'Ig M antibody'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Fadeyi, Emmanuel A., Tawfeq Naal, Mary Green, Julie H. Simmons, Mary Rose Jones, and Gregory J. Pomper. "Anti-M–Induced Delayed Hemolytic Transfusion Reaction." Laboratory Medicine 51, no. 4 (2019): 426–29. http://dx.doi.org/10.1093/labmed/lmz078.

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Abstract Background Anti-M is most often assumed to be naturally occurring and can be comprised of a mixture of predominantly immunoglobulin(Ig)M with a lesser IgG component. Anti-M-antibodies usually do not react at 37°C and therefore are considered to be of little clinical significance. Methods A 28-year-old man presented with hemorrhagic shock from numerous injuries sustained in a motor vehicle collision. The patient received several units of red blood cells (RBCs). The antibody screen, the direct antiglobulin test (DAT), and the RBC genotype were sent for laboratory evaluation. Results A t

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Elliott, T. J., M. J. Glennie, H. M. McBride, and G. T. Stevenson. "Analysis of the interaction of antibodies with immunoglobulin idiotypes on neoplastic B lymphocytes: implications for immunotherapy." Journal of Immunology 138, no. 3 (1987): 981–88. http://dx.doi.org/10.4049/jimmunol.138.3.981.

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Abstract We have examined the reactions of a panel of nine monoclonal anti-idiotype antibodies with the surface immunoglobulin in situ on guinea pig L2C leukemic lymphocytes. Equilibrium binding constants were shown to range between 10(7) and 10(8) M-1 for univalent Fab' gamma fragments and between 10(8) and 10(9) M-1 for intact IgG. Saturation of the cell surface binding sites was achieved with 2.9 X 10(5) Fab' gamma molecules/cell and 1.2 X 10(5) IgG molecules/cell for each antibody, a result that is consistent with a bivalent mode of interaction for the IgG. Despite these overall similariti

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Hinton, Dennis M., and Mushtaq A. Khan. "Evaluation of the Miniature Swine for Use in Immunotoxicity Assessment: I. Quantitation of Humoral Responses to Sheep Red Blood Cells and Effects of Cyclophosphamide." Journal of the American College of Toxicology 8, no. 5 (1989): 1039–52. http://dx.doi.org/10.3109/10915818909018064.

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T-cell-dependent and t-independent humoral responses as well as cell-mediated re-sponses(1) were assessed with groups of young, Hormel-Hanford miniature swine. Test antigens established in various immunotoxicity studies with rodents were used. Results with the widely used t-dependent test antigen, sheep red blood cells (SRBC), are presented in this report. Groups of swine were immunized with varying dosages of SRBC to evaluate basal responses. Serum antibody titers were estimated by the standardized hemolysin (HLY) visual endpoint (EP) assay and a quantitative spectro-photometric (SP) variatio

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4

Guy, James S., and Leon N. D. Potgieter. "Kinetics of antibody formation after the reactivation of bovine herpesvirus-1 infection in cattle." American Journal of Veterinary Research 46, no. 4 (1985): 899–901. https://doi.org/10.2460/ajvr.1985.46.04.899.

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SUMMARY Holstein heifers previously infected with bovine herpesvirus-1 were treated with corticosteroids to reactivate latent infection. The kinetics of serum immunoglobulin (Ig) M, IgG1, and IgG2 antibody formation were determined. The secondary immune response which developed as a consequence of virus reactivation was characterized by an anamnestic IgG antibody response. Secondary IgGl and IgG2 antibody formation constituted the IgG antibody response. In addition, secondary IgM antibody formation was elicited by this form of bovine herpesvirus-1 antigenic exposure.

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Gong, Xiaoting, Huige Yan, Junfan Ma, et al. "Macrophage-Derived Immunoglobulin M Inhibits Inflammatory Responses via Modulating Endoplasmic Reticulum Stress." Cells 10, no. 11 (2021): 2812. http://dx.doi.org/10.3390/cells10112812.

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Immunoglobulin (Ig), a characteristic marker of B cells, is a multifunctional evolutionary conserved antibody critical for maintaining tissue homeostasis and developing fully protective humoral responses to pathogens. Increasing evidence revealed that Ig is widely expressed in non-immune cells; moreover, Ig produced by different lineages cells plays different biological roles. Recently, it has been reported that monocytes or macrophages also express Ig. However, its function remains unclear. In this study, we further identified that Ig, especially Ig mu heavy chain (IgM), was mainly expressed

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Seriwatana, Jitvimol, Mrigendra P. Shrestha, Robert M. Scott, et al. "Clinical and Epidemiological Relevance of Quantitating Hepatitis E Virus-Specific Immunoglobulin M." Clinical and Vaccine Immunology 9, no. 5 (2002): 1072–78. http://dx.doi.org/10.1128/cdli.9.5.1072-1078.2002.

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ABSTRACT Diagnosis of acute hepatitis E by detection of hepatitis E virus (HEV)-specific immunoglobulin M (IgM) is an established procedure. We investigated whether quantitation of HEV IgM and its ratio to HEV total Ig furnished more information than conventional IgM tests that are interpreted as positive or negative. A previously described indirect immunoassay for total Ig against a baculovirus-expressed HEV capsid protein was modified to quantitate HEV-specific IgM in Walter Reed (WR) antibody units by using a reference antiserum and the four-parameter logistic model. A receiver-operating ch

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Kim, Dong-Min, Choon-Mee Kim, and Na Ra Yun. "2138. Follow-up Investigation of Antibody Titers and Diagnostic Antibody Cut-Off Values in Scrub Typhus Patients in Korea." Open Forum Infectious Diseases 6, Supplement_2 (2019): S724—S725. http://dx.doi.org/10.1093/ofid/ofz360.1818.

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Abstract Background Scrub typhus is a mite-borne infectious disease caused by Orientia tsutsugamushi. There have been few follow-up studies assessing antibody titers using serologic tests from various commercial labs. Methods A prospective investigation to assess antibody titers of scrub typhus patients and seroprevalence for health checkup individuals were evaluated. The antibody titers of former patients diagnosed with scrub typhus at least 1 year and a maximum of 13 years were also investigated. The following tests were performed simultaneously: (i) immunofluorescence antibody assays (IFAs)

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Chan, Owen T. M., Lynn G. Hannum, Ann M. Haberman, Michael P. Madaio, and Mark J. Shlomchik. "A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus." Journal of Experimental Medicine 189, no. 10 (1999): 1639–48. http://dx.doi.org/10.1084/jem.189.10.1639.

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The precise role of B cells in systemic autoimmunity is incompletely understood. Although B cells are necessary for expression of disease (Chan, O., and M.J. Shlomchik. 1998. J. Immunol. 160:51–59, and Shlomchik, M.J., M.P. Madaio, D. Ni, M. Trounstine, and D. Huszar. 1994. J. Exp. Med. 180:1295–1306), it is unclear whether autoantibody production, antigen presentation, and/or other B cell functions are required for the complete pathologic phenotype. To address this issue, two experimental approaches were used. In the first, the individual contributions of circulating antibodies and B cells we

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Jaskowski, T. D., T. B. Martins, C. M. Litwin, and H. R. Hill. "Immunoglobulin (Ig) M antibody against myelin associated glycoprotein (MAG): A comparison of methods." Journal of Clinical Laboratory Analysis 18, no. 4 (2004): 247–50. http://dx.doi.org/10.1002/jcla.20031.

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10

Pelletier, R. P., R. G. Ohye, A. Vanbuskirk, et al. "Importance of endothelial VCAM-1 for inflammatory leukocytic infiltration in vivo." Journal of Immunology 149, no. 7 (1992): 2473–81. http://dx.doi.org/10.4049/jimmunol.149.7.2473.

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Abstract The microvascular endothelia of rejecting DBA/2----C57B1/6 murine cardiac allografts develop reactivity with the mAb M/K-2, which recognizes the murine homologue of the human leukocyte adhesion molecule VCAM-1. This reactivity does not develop in DBA/2----DBA/2 cardiac isografts or normal DBA/2 cardiac tissues. To determine whether endothelial VCAM-1 plays a role in allograft inflammation, cardiac allograft recipients were treated with M/K-2 antibody and monitored for leukocytic graft infiltration and graft survival. Treatment of the graft recipients with 200 micrograms/day M/K-2 Ig p

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Murray, David L., and Maria A. V. Willrich. "Applications of Mass Spectrometry Proteomic Methods to Immunoglobulins in the Clinical Laboratory." Clinical Chemistry 70, no. 12 (2024): 1422–35. https://doi.org/10.1093/clinchem/hvae179.

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Abstract Background Immunoglobulin (Ig) measurements in the clinical laboratory have been traditionally performed by nephelometry, turbidimetry, electrophoresis, and ELISA assays. Mass spectrometry (MS) measurements have the potential to provide deeper insights on the nature of these markers. Content Different approaches—top-down, middle-down, or bottom-up—have been described for measuring specific Igs for endogenous monoclonal immunoglobulins (M-proteins) and exogenous therapeutic monoclonal antibody therapies (t-mAbs). Challenges arise in distinguishing the Ig of interest from the polyclonal

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Lymberi, Peggy, Evangelos Terpos, Aikaterini Hatzioannou, et al. "High Frequency of Monoclonal Immunoglobulins Exhibiting Natural Autoantibody-Like Activity in Patients with Multiple Myeloma and Waldenström Macroglobulinemia." Blood 118, no. 21 (2011): 2893. http://dx.doi.org/10.1182/blood.v118.21.2893.2893.

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Abstract Abstract 2893 Serum monoclonal immunoglobulins (M-Igs) of patients with monoclonal gammopathies are known to possess antibody activity against autoantigens, bacterial antigens and haptens, but their incidence is controversial. So far, high incidence of autoantibodies (autoAb) have been demonstrated against actin, Ro/SS-A and La/SS-B for M-Igs of all three classes (IgG, IgA, IgM) and against Fc fragment of IgG and the Ii group exclusively for IgM M-Ig. Other less frequent antiboby specificities of M-Igs include anti-myosin, anti-tubulin, anti-thyroglobulin and anti-DNA. M-Igs with anti

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Snapper, C. M., J. J. Hooley, J. F. Urban, and F. D. Finkelman. "Lack of Fc epsilon RII expression by murine B cells after in vivo immunization is directly associated with Ig secretion and not Ig isotype switching." Journal of Immunology 146, no. 7 (1991): 2161–68. http://dx.doi.org/10.4049/jimmunol.146.7.2161.

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Abstract The "low affinity" Fc receptor for IgE (Fc epsilon RII) has been reported to be absent from normal murine and human B cells that express a membrane (m)Ig isotype other than mIgM or mIgD in vivo. This would suggest that Fc epsilon RII expression is specifically lost after in vivo Ig isotype switching. We demonstrate that during a murine immune response to the bacterium Brucella abortus, to goat anti-mouse IgD (G alpha M delta) antibody, or to infection with the nematode parasites Nippostrongylus brasilienis or Heligmosomoides polygyrus, Fc epsilon RII expression is low or absent on vir

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Goroff, D. K., J. M. Holmes, H. Bazin, F. Nisol, and F. D. Finkelman. "Polyclonal activation of the murine immune system by an antibody to IgD. XI. Contribution of membrane IgD cross-linking to the generation of an in vivo polyclonal antibody response." Journal of Immunology 146, no. 1 (1991): 18–25. http://dx.doi.org/10.4049/jimmunol.146.1.18.

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Abstract The injection of mice with a foreign, polyclonal antibody to IgD sequentially induces: 1) activation of B cells by cross-linking of their cell membrane (m) IgD; 2) B cell processing and presentation of the bound anti-IgD antibody to T cells; 3) activation of these T cells; and 4) T-dependent stimulation of B cell differentiation into IgG1 secreting cells. To determine whether the cross-linking of B cell membrane IgD and/or the resulting B cell activation that follows contribute to the generation of the polyclonal IgG1 response, we examined the abilities of three sets of anti-delta mAb

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Morris, S. C., K. B. Madden, J. J. Adamovicz, et al. "Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection." Journal of Immunology 152, no. 3 (1994): 1047–56. http://dx.doi.org/10.4049/jimmunol.152.3.1047.

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Abstract The effects of murine rIL-12 on cytokine gene expression and Ig secretion were studied in vivo. In untreated mice IL-12 enhanced IFN-gamma and IL-10 gene expression and protein secretion, reduced base line IL-3 and IL-4 gene expression, and increased serum IgG2a concentration. In mice that had been injected with goat anti-mouse IgD antibody (G alpha M delta) to induce increases in IL-3, IL-4, and IL-10 gene expression and serum IgE, IgG1, IgG2a, and IgG3 concentrations, the simultaneous injection of IL-12 enhanced IFN-gamma and IL-10 gene expression and suppressed IL-3 and IL-4 gene e

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Emelianov, Vladimir U., Tatiana Skvortsova, Lilia V. Mikhailova, and Elena N. Shamitova. "Serum Antibody Ig G and Ig M Titers for Opisthorchis felineus Correlate with Eggs in Faeces - a Comprehensive Study in Chuvash Republic, Russia." Asian Pacific Journal of Cancer Prevention 17, no. 1 (2016): 281–83. http://dx.doi.org/10.7314/apjcp.2016.17.1.281.

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La Manna, Marco P., Mojtaba Shekarkar-Azgomi, Giusto D. Badami, et al. "Impact of Mycobacterium tuberculosis Infection on Human B Cell Compartment and Antibody Responses." Cells 11, no. 18 (2022): 2906. http://dx.doi.org/10.3390/cells11182906.

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Tuberculosis (TB) remains one of the most important health challenges worldwide. Control of the TB epidemic has not yet been achieved because of the lack of an effective vaccine and rapid and sensitive diagnostic approaches, as well as the emergence of drug-resistant forms of M. tuberculosis. Cellular immunity has a pivotal role against M. tuberculosis infection, but the role of humoral immunity is still controversial. We analyzed the frequency, absolute counts, and phenotypic and functional subsets of B lymphocytes in the peripheral blood of patients with active TB and subjects with latent in

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Fleshner, M., F. X. Brennan, K. Nguyen, L. R. Watkins, and S. F. Maier. "RU-486 blocks differentially suppressive effect of stress on in vivo anti-KLH immunoglobulin response." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 271, no. 5 (1996): R1344—R1352. http://dx.doi.org/10.1152/ajpregu.1996.271.5.r1344.

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Exposure to stressors can affect various aspects of immune function, including the antibody response. We have previously reported that rats exposed to an acute session of inescapable tail shock (IS) show long-term reductions in anti-keyhole limpet hemocyanin (KLH) immunoglobulin (Ig) M and IgG and a failure to expand Th1-like cells in response to KLH. To further investigate the potential role of decreased Th1-like cells in the IS-induced reduction of anti-KLH Ig, we examined two isotypes of IgG, IgG1 and IgG2a. Isotype switching is under cytokine control. Interleukin-4 helps B cells switch fro

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Bradwell, Arthur R., Stephen J. Harding, Nicolas J. Fourrier та ін. "Assessment of Monoclonal Gammopathies by Nephelometric Measurement of Individual Immunoglobulin κ/λ Ratios". Clinical Chemistry 55, № 9 (2009): 1646–55. http://dx.doi.org/10.1373/clinchem.2009.123828.

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Abstract Background: Currently, monoclonal immunoglobulins are identified and quantified from bands on electrophoretic gels. As an alternative, clonality might be determined by measuring the separate light chain types of each Ig class to allow numerical assessment of Ig′κ/Ig′λ ratios, analogous to free light chain κ/λ ratios. Methods: Using immunization, tolerization, and adsorption procedures, we prepared sheep antibodies against each of the 6 separate molecules, IgGκ, IgGλ, IgAκ, IgAλ, IgMκ, and IgMλ. Antibody targets comprised the junctional epitopes between the heavy chain and light chain

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Antin, J. H., S. G. Emerson, P. Martin, N. Gadol, and K. A. Ault. "Leu-1+ (CD5+) B cells. A major lymphoid subpopulation in human fetal spleen: phenotypic and functional studies." Journal of Immunology 136, no. 2 (1986): 505–10. http://dx.doi.org/10.4049/jimmunol.136.2.505.

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Abstract Examination of the cell surface phenotype of fetal splenic lymphocytes demonstrated a major, novel subpopulation of B cells that co-express Leu-1 (CD5) in addition to B cell differentiation antigens (Leu-1+ B cells). These cells are similar to some conventional B cells in that they express HLA-DR, Leu-12, and B1, as well as both immunoglobulin (Ig) M and IgD. They comprise 40 to 60% of total splenic B cells in the fetus but are infrequent in fetal liver and adult spleen. Fetal Leu-1+ B cells do not respond to pokeweed mitogen with either proliferation or Ig secretion, and in contrast

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Husada, Dominicus, Kartika Handayani, Dwiyanti Puspitasari, Leny Kartina, Parwati Setiono, and Ismoedijanto Moedjito. "Measles Oral Swab as Field-Based Screening Test in Children." Open Forum Infectious Diseases 4, suppl_1 (2017): S355. http://dx.doi.org/10.1093/ofid/ofx163.858.

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Abstract Background Indonesia suffered from measles outbreak for many times, especially in the last five years. Most patients were children. WHO used measles specific Ig M from the blood as a gold standard but this test is invasive. Anti measles Ig M oral swab has been used as an alternative however there has not been any study about this method in Indonesia. The objective of this study was to validate anti measles Ig M oral swab for the diagnosis of measles in children. Methods This study was performed in Dr. Soetomo Hospital in Surabaya for three months period. Children with fever and rash s

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Gorban, Nataliia E., Irina B. Vovk, Iryna M. Nikitina, Valentina K. Kondratiuk, and Nadiia O. Yemets. "IMMUNOGLOBULIN INDICATORS TO VIRUSES CYTOMEGAL AND GENITAL HERPES IN THE BLOOD SERUM OF WOMEN WITH NON-ATIPICAL ENDOMETRIAL HYPERPROLIFETATIVE PATHOLOGY." Wiadomości Lekarskie 73, no. 8 (2020): 1600–1604. http://dx.doi.org/10.36740/wlek202008102.

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The aim of the study was to analyze the level of Ig M- and Ig G-antibody (Ab) for cytomegalovirus (CMV) and herpes simplex virus type 2 (HSV-2) in serum of women with non-atypical endometrial hyperproliferative pathology. Materials and methods: The analysis of immunoglobulin indices to CMV and HSV-2 in serum of women with non-atypical endometrial hyperproliferative pathology. In women with uterine body polyps the presence of CMV in the uterine cavity was found in 54.8% of cases, in women with non-atypical endometrial hyperplasia in 38.3% of cases. The levels of Ig G-Ab and Ig M-Ab to CMV in se

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Brink, R., C. C. Goodnow, J. Crosbie, et al. "Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen." Journal of Experimental Medicine 176, no. 4 (1992): 991–1005. http://dx.doi.org/10.1084/jem.176.4.991.

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A series of immunoglobulin (Ig)-transgenic mice were generated to study the functional capabilities of the IgM and IgD classes of B lymphocyte antigen receptor in regulating both cellular development and responses to specific antigen. B cells from Ig-transgenic mice expressing either hen-egg lysozyme (HEL)-specific IgM or IgD alone were compared with B cells from mice that coexpressed IgM and IgD of the same anti-HEL specificity. In all three types of Ig-transgenic mice, conventional B cells specific for HEL exhibited exclusion of endogenous Ig expression and matured to populate the usual micr

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Nurinasari, Hafi, Sajidan, Bambang Purwanto, Dono Indarto, and Didik T. Subekti. "Effect of Toxoplasma Infection Dosage on Igg, Igm, Fetus Weight and Body Length, and Necrosis of Placenta and Fetal Heart." HAYATI Journal of Biosciences 31, no. 3 (2024): 596–602. http://dx.doi.org/10.4308/hjb.31.3.596-602.

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One of the most prevalent zoonotic illnesses in the world, toxoplasmosis, affects both humans and animals and is caused by the parasite Toxoplasma gondii. The infection will trigger the immune system to increase antibody production. This study aims to determine the dose of toxoplasma that causes necrosis in rats placental and fetal hearts. This study was laboratory experimental research with a Randomized Control Trial (RCT). The study design used a post-test only with a control group design. The Ig G variable obtained from the control group (CG) and treatment group 3 (TG3) is the most signific

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Harada, Yuichi, Masamichi Muramatsu, Toshikatsu Shibata, Tasuku Honjo, and Kazumichi Kuroda. "Unmutated Immunoglobulin M Can Protect Mice from Death by Influenza Virus Infection." Journal of Experimental Medicine 197, no. 12 (2003): 1779–85. http://dx.doi.org/10.1084/jem.20021457.

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To elucidate the role of class switch recombination (CSR) and somatic hypermutation (SHM) in virus infection, we have investigated the influence of the primary and secondary infections of influenza virus on mice deficient of activation-induced cytidine deaminase (AID), which is absolutely required for CSR and SHM. In the primary infection, AID deficiency caused no significant difference in mortality but did cause difference in morbidity. In the secondary infection with a lethal dose of influenza virus, both AID−/− and AID+/− mice survived completely. However, AID−/− mice could not completely b

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Traugott, Marianna, Stephan Walter Aberle, Judith Helene Aberle, et al. "Performance of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Assays in Different Stages of Infection: Comparison of Commercial Enzyme-Linked Immunosorbent Assays and Rapid Tests." Journal of Infectious Diseases 222, no. 3 (2020): 362–66. http://dx.doi.org/10.1093/infdis/jiaa305.

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Abstract We comparatively assessed sensitivities and specificities of 4 commercial enzyme-linked immunosorbent assays (ELISAs) and 2 rapid tests in 77 patients with polymerase chain reaction–confirmed severe acute respiratory syndrome coronavirus 2 infection, grouped by interval since symptom onset. Although test sensitivities were low (&lt;40%) within the first 5 days after disease onset, immunoglobulin (Ig) M, IgA, and total antibody ELISAs increased in sensitivity to &gt;80% between days 6 and 10 after symptom onset. The evaluated tests (including IgG and rapid tests) provided posit

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Muttineni. "Antiviral Potency of HIV Long term Survivors Sera." American Journal of Science and Medical Research 8, no. 2 (2022): 12–15. https://doi.org/10.5281/zenodo.7340286.

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<strong>ABSTRACT</strong> The survival of a small fraction (5-15%) of individuals without immunologic deterioration after being infected with HIV for more than 8-10 years without any therapy is still elusive. Long-term non-progressors of HIV -1 infected children serve as ideal models to study virological, genetic and immunological characteristics to determine factors associated with slow progression of disease and death due to their natural control of HIV-1 infection. LTNP and LTPs whole blood were collected by venipuncture in CPT tubes. Blood was transported to the lab within 3- 6 hours in a

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Buluç, Halil, Burak Kara, and Fahri Acar. "Perioperative SARS-CoV-2 screening and comparison of immunoglobin values, a retrospective study." Eurasian Journal of Anesthesiology and Intensive Care 2, no. 2 (2025): 61–66. https://doi.org/10.51271/eajaic-0031.

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Aims: The SARS-CoV-2 pandemic has posed significant challenges to perioperative management, particularly in the context of preoperative screening and immune response evaluation. Various methods, including polymerase chain reaction (PCR) tests, immunoglobulin (Ig) level assessments, chest X-rays, and computerized tomographies, have been employed to mitigate risks. This study aims to explore the differences in immune responses, particularly Ig levels, between vaccinated and non-vaccinated individuals undergoing surgery during the pandemic. Methods: During the study period, data from 656 patients

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Wasfy, Samia, John Nishikawa, and Martin Petric. "Seroprevalence of Immunoglobulin G Antibody to Parvovirus B19 in Ontario." Canadian Journal of Infectious Diseases 7, no. 5 (1996): 313–16. http://dx.doi.org/10.1155/1996/941356.

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The prevalence of antibody to parvovirus B19 was assessed in two populations. In a group of 494 residents from Ontario and the Maritimes, virus-specific immunoglobulin (Ig) M antibody, a marker of acute infection, was found throughout the year but was most prevalent during the late winter and early spring months. The overall prevalence of IgG antibody in this group was 30.3%. In an effort to examine age-specific prevalence in this population, a second group of sera from 210 pediatric patients at The Hospital for Sick Children, Toronto, Ontario and from Red Cross blood donors was tested for the

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Mukae, O., Y. Nawa, S. Matsukura, H. Taniguchi, F. Uchiyama, and J. Ashitani. "Case report: Paragonimiasis westermani with seroconversion from immunoglobulin (Ig) m to IgG antibody with the clinical course." American Journal of Tropical Medicine and Hygiene 65, no. 6 (2001): 837–39. http://dx.doi.org/10.4269/ajtmh.2001.65.837.

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Landreth, KS, R. Narayanan, and K. Dorshkind. "Insulin-like growth factor-I regulates pro-B cell differentiation." Blood 80, no. 5 (1992): 1207–12. http://dx.doi.org/10.1182/blood.v80.5.1207.1207.

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Abstract Progression of B-lymphocyte development in the bone marrow of postnatal mammals is marked by progressive rearrangement and expression of immunoglobulin (Ig) heavy- and light-chain genes. Following productive VHDJH gene rearrangement in the Ig heavy-chain gene complex, mu-heavy chain is the first Ig gene product expressed in cells committed to the B-lymphoid differentiation pathway. Interleukin (IL)-7 has been shown to stimulate proliferation of pre-B cells following c mu expression and this proliferative stimulus is potentiated by kit ligand (KL). However, it appears that neither of t

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Landreth, KS, R. Narayanan, and K. Dorshkind. "Insulin-like growth factor-I regulates pro-B cell differentiation." Blood 80, no. 5 (1992): 1207–12. http://dx.doi.org/10.1182/blood.v80.5.1207.bloodjournal8051207.

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Progression of B-lymphocyte development in the bone marrow of postnatal mammals is marked by progressive rearrangement and expression of immunoglobulin (Ig) heavy- and light-chain genes. Following productive VHDJH gene rearrangement in the Ig heavy-chain gene complex, mu-heavy chain is the first Ig gene product expressed in cells committed to the B-lymphoid differentiation pathway. Interleukin (IL)-7 has been shown to stimulate proliferation of pre-B cells following c mu expression and this proliferative stimulus is potentiated by kit ligand (KL). However, it appears that neither of these cyto

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Bouvet, J. P., R. Pirès, S. Iscaki, and J. Pillot. "Nonimmune macromolecular complexes of Ig in human gut lumen. Probable enhancement of antibody functions." Journal of Immunology 151, no. 5 (1993): 2562–71. http://dx.doi.org/10.4049/jimmunol.151.5.2562.

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Abstract Protein Fv, a human sialoprotein recently described in the stools of patients suffering from liver diseases, binds the variable domain of H chains without impairing Ag binding. Normal subjects are shown here to secrete protein Fv under a hidden form, saturated with luminal Ig. In feces, the nonimmune complexes are essentially of 1800 and 800 kDa M(r); they contain protein Fv molecules bound with F(ab')2 fragments produced by cleavage of Secretory IgA during colonic transit. The 800-kDa complexes correspond to 6 molecules of F(ab')2 fragments bound to a sole protein Fv dimer. This was

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Mia, Md Abdul Ali, Mamun Mostafi, Shaila Perveen, Niamul Gani Chowdhury, Mir Azimuddin Ahmed, and SM Mizanur Rahman. "Acute Acalculus Cholecystitis in Dengue Hemorrhagic Fever-A Case Report." Journal of Bangladesh College of Physicians and Surgeons 35, no. 3 (2017): 155–57. http://dx.doi.org/10.3329/jbcps.v35i3.34350.

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Presently Dengue appears with its varied features of presentation and progression. We report a case of acalculus cholecystitis in DHF from department of medicine, Combined Military Hospital, Dhaka. The patient presented with fever and diarrhea later developing abdominal pain. Her platelet counts were low and Dengue antibody test (Ig M) was positive with altered liver enzymes. Ultrasound showed thick walled gall bladder with clear lumen without stone or sluge, a feature of acute acalculous cholecystitis. The patient was successfully managed conservatively.J Bangladesh Coll Phys Surg 2017; 35(3)

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Stach, R. M., and D. A. Rowley. "A first or dominant immunization. II. Induced immunoglobulin carries transforming growth factor beta and suppresses cytolytic T cell responses to unrelated alloantigens." Journal of Experimental Medicine 178, no. 3 (1993): 841–52. http://dx.doi.org/10.1084/jem.178.3.841.

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Fresh sera from mice immunized by bearing an immunogenic tumor or by repeated injections of allogeneic spleen cells or xenogeneic erythrocytes powerfully suppress cytolytic T cell responses in one-way mixed lymphocyte cultures. Suppression is not antigen specific, though is mediated by immunoglobulin (Ig)G specific for the immunizing antigen. Suppression caused by IgG mimics that caused by active transforming growth factor beta (TGF-beta). IgG associates with or carries latent TGF-beta; however, suppression caused by the complex of IgG-TGF-beta requires macrophages (M phi), whereas active TGF-

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Westenbrink, F., and T. G. Kimman. "Immunoglobulin M-specific enzyme-linked immunosorbent assay for serodiagnosis of bovine respiratory syncytial virus infections." American Journal of Veterinary Research 48, no. 7 (1987): 1132–37. https://doi.org/10.2460/ajvr.1987.48.07.1132.

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SUMMARY An antibody-capture enzyme-linked immunosorbent assay (elisa) for detection of immunoglobulin (Ig) M antibodies to bovine respiratory syncytial virus (brsv) in cattle was developed. Monoclonal antibody to bovine IgM was used as the catching antibody. The IgM-elisa was used, as well as a brsv-specific IgG elisa to determine the kinetics of IgM and IgG antibody responses to brsv infections in cattle. High IgM and IgG antibody titers developed after naturally occurring or induced brsv infection of calves (6 to 7 months old). Induced infection resulted in an IgM response that was first det

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Rhee, Ki-Jong, Paul J. Jasper, Periannan Sethupathi, Malathy Shanmugam, Dennis Lanning, and Katherine L. Knight. "Positive selection of the peripheral B cell repertoire in gut-associated lymphoid tissues." Journal of Experimental Medicine 201, no. 1 (2004): 55–62. http://dx.doi.org/10.1084/jem.20041849.

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Gut-associated lymphoid tissues (GALTs) interact with intestinal microflora to drive GALT development and diversify the primary antibody repertoire; however, the molecular mechanisms that link these events remain elusive. Alicia rabbits provide an excellent model to investigate the relationship between GALT, intestinal microflora, and modulation of the antibody repertoire. Most B cells in neonatal Alicia rabbits express VHn allotype immunoglobulin (Ig)M. Within weeks, the number of VHn B cells decreases, whereas VHa allotype B cells increase in number and become predominant. We hypothesized th

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Colombatti, M., V. G. Johnson, H. A. Skopicki, B. Fendley, M. S. Lewis, and R. J. Youle. "Identification and characterization of a monoclonal antibody recognizing a galactose-binding domain of the toxin ricin." Journal of Immunology 138, no. 10 (1987): 3339–44. http://dx.doi.org/10.4049/jimmunol.138.10.3339.

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Abstract A monoclonal antibody raised against purified ricin B chain, 75/3B12, blocked ricin toxicity 30- to 100-fold in vitro. The 75/3B12 IgG and F(ab')2 blocked ricin binding to cell surface galactose-containing receptors. The 75/3B12 Fab bound ricin D with a Ka of 10(7) M-1, and this binding was blocked by asialofetuin, lactose, and N-acetylgalactosamine--molecules which interact with the ricin galactose-binding site--but not by fetuin, sucrose, or glucose. The 75/3B12 Fab contained no detectable carbohydrate and, according to several lines of evidence, did not bind ricin via Ig carbohydra

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Ritter, K., H. Brestrich, B. Nellen, H. Kratzin, H. Eiffert, and R. Thomssen. "Autoantibodies against triosephosphate isomerase. A possible clue to pathogenesis of hemolytic anemia in infectious mononucleosis." Journal of Experimental Medicine 171, no. 2 (1990): 565–70. http://dx.doi.org/10.1084/jem.171.2.565.

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In sera from patients with acute EBV, infection and the clinical symptoms of infectious mononucleosis antibodies of the Ig class M were found that are directed against two cellular proteins. The molecular mass of these proteins was determined to be 29 (p29) and 26 kD (p26), respectively, in SDS-PAGE. P29 was identified as part of the glycolytic enzyme triosephosphate isomerase (TPI) by comparison of the NH2-terminal amino acid sequences. A purified antibody against TPI induces a 51Cr release from human erythrocytes. Possibly, anti-TPI causes hemolysis, which is an infrequent but serious sympto

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Petri, Michelle. "Improvements in diagnosis and risk assessment of primary and secondary antiphospholipid syndrome." Hematology 2019, no. 1 (2019): 415–20. http://dx.doi.org/10.1182/hematology.2019000046.

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Abstract Classification criteria for antiphospholipid syndrome have not been updated since the revised Sapporo classification criteria were published in 2006. These criteria have limitations in that they omit nonclassical manifestations (hematologic and neurologic), include anticardiolipin and anti–β2-glycoprotein I immunoglobulin (Ig)M isotypes, and do not separately consider primary (no autoimmune disease) or secondary (usually systemic lupus erythematosus) disease. Recent findings in antiphospholipid antibody include fluctuation of antiphospholipid antibodies, recognition that IgA isotypes

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Snapper, C. M., W. Waegell, H. Beernink, and J. R. Dasch. "Transforming growth factor-beta 1 is required for secretion of IgG of all subclasses by LPS-activated murine B cells in vitro." Journal of Immunology 151, no. 9 (1993): 4625–36. http://dx.doi.org/10.4049/jimmunol.151.9.4625.

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Abstract Addition of transforming growth factor-beta 1 (TGF-beta 1) to in vitro cultures of murine B cells activated with bacterial LPS selectively stimulates IgG2b and IgA class switching and decreases cellular proliferation. To assess a possible role for endogenous TGF-beta in modulating the Ig isotypes produced by LPS-activated cells, we utilized a neutralizing anti-TGF-beta mAb to abrogate endogenous TGF-beta activity. Anti-TGF-beta antibody, over a range of relatively low cell densities, strikingly inhibited both IgG3 and IgG2b production in response to LPS, with little or no change in th

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Herman, Reni. "Clinical and virological profile of Dengue cases: a study in Samarinda and Manado." Health Science Journal of Indonesia 9, no. 2 (2018): 76–81. http://dx.doi.org/10.22435/hsji.v9i2.909.

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Latar Belakang: Infeksi virus dengue masih merupakan masalah kesehatan di Indonesia. Studi inidilakukan di Samarinda dan Manado, tujuannya untuk mendapatkan profil klinis dan virologi daripenderita anak dan dewasa di Wilayah Tengah Indonesia. Metode: Ini merupakan studi deskriptif, kasus infeksi dengue didapat dari Rumah Sakit Umum diSamarinda dan Manado pada tahun 2012-2013. Sampel darah berasal dari penderita infeksi dengue yangdirawat di Bagian Anak dan Penyakit Dalam. Konfirmasi infeksi dengue dilakukan dengan pemeriksaannested RT-PCR, deteksi antibodi Ig M dan Ig G dilakukan dengan

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Callister, Steven M., Rhonda L. LaFleur, Dean A. Jobe, Steven D. Lovrich, and Terri L. Wasmoen. "Antibody responses toBorrelia burgdorferiouter surface proteins C and F in experimentally infected Beagle dogs." Journal of Veterinary Diagnostic Investigation 27, no. 4 (2015): 526–30. http://dx.doi.org/10.1177/1040638715583868.

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Antibody levels to outer surface proteins C and F (OspC and OspF, respectively) in sera collected from laboratory Beagle dogs at 1, 2, and 4 months after challenge with infected black-legged ticks ( Ixodes scapularis) were determined. Each dog was confirmed by culture to harbor Borrelia burgdorferi in the skin ( n = 10) or the skin and joints ( n = 14). Significant levels of immunoglobulin M (Ig)M or IgG anti-OspC antibodies were detected in single serum samples from only 3 (13%) dogs. Similarly, IgM anti-OspF antibodies were detected in only 1 (4%) serum sample collected from a dog with B. bu

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Webb, S. R., A. Okamoto, Y. Ron, and J. Sprent. "Restricted tissue distribution of Mlsa determinants. Stimulation of Mlsa-reactive T cells by B cells but not by dendritic cells or macrophages." Journal of Experimental Medicine 169, no. 1 (1989): 1–12. http://dx.doi.org/10.1084/jem.169.1.1.

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Evidence was sought on the tissue distribution of Mlsa determinants, a class of cell-associated non-H-2 alloantigens that is highly immunogenic for unprimed T cells. Whereas normal CD4+ T cells and an Mlsa-reactive T hybridoma gave strong responses to Mlsa-positive stimulator populations containing Ig+ B cells, anti-Mlsa responses to B-depleted stimulators were almost undetectable. The B-depleted stimulators tested included Thy-1- spleen cells from mu-suppressed mice (mice treated with anti-mu antibody from birth) and J11d- preparations of spleen dendritic cells (DC) and peritoneal macrophages

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Charan, S., and R. M. Zinkernagel. "Antibody mediated suppression of secondary IgM response in nude mice against vesicular stomatitis virus." Journal of Immunology 136, no. 8 (1986): 3057–61. http://dx.doi.org/10.4049/jimmunol.136.8.3057.

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Abstract Nude mice immunized with either of the two serotypes of vesicular stomatitis virus (VSV), VSV Indiana (VSV-Ind) or VSV-New Jersey (VSV-NJ), showed an early T cell independent immunoglobulin (Ig) M antibody response comparable with normal euthymic mice. Unlike euthymic mice, however, nude mice reinjected with the homologous serotype were unable to mount a second measurable serum neutralizing (SN) antibody response; a second injection with the heterologous serotype induced a normal primary type of SN antibody response. The serotype-specific refractoriness to a second challenge recovered

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George, J., S. J. Penner, J. Weber, J. Berry, and J. L. Claflin. "Influence of membrane Ig receptor density and affinity on B cell signaling by antigen. Implications for affinity maturation." Journal of Immunology 151, no. 11 (1993): 5955–65. http://dx.doi.org/10.4049/jimmunol.151.11.5955.

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Abstract We have initiated a series of experiments to explore the effect of changes in density of the surface Ig receptor (mIg) on Ag:mIg interactions. We transfected into the surface Ig-negative B cell line M12.4 H and L chain constructs known to effect a 10-fold change in antibody binding affinity for the naturally occurring hapten phosphocholine (PC). Two sets of stable transfectants were generated and those expressing levels of mIg comparable to the range normally seen on splenic B cells were studied. One set expressed an unmutated VH and an unmutated VL. The second set expressed the same

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Mast, Jan, Johan Buyse, and Bruno M. Goddeeris. "Dietary L-carnitine supplementation increases antigen-specific immunoglobulin G production in broiler chickens." British Journal of Nutrition 83, no. 2 (2000): 161–66. http://dx.doi.org/10.1017/s0007114500000209.

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The usefulness of supplementary dietary L-CARNITINE AS AN IMMUNOMODULATOR TO INCREASE ANTIGEN-SPECIFIC ANTIBODY LEVELS WAS ANALYSED IN 2–6-WEEK-OLD BROILERS. THE CHICKENS RECEIVED COMMERCIAL FEEDS EITHER UNSUPPLEMENTED (STARTER FEED 17·8 MG CARNITINE/KG, FINISHER DIET 22·9 MG CARNITINE/KG) OR SUPPLEMENTED WITH l-carnitine (100 mg carnitine/kg added to feed). At 14 d of age, both groups were distributed in equal numbers and sex ratios over two environmentally controlled chambers where temperature (28°) was either reduced immediately to 20°, or gradually to 22° at 36 d of age. Antigen-specific i

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Rao, T. D., A. A. Maghazachi, A. V. González, and J. M. Phillips-Quagliata. "A novel IgA receptor expressed on a murine B cell lymphoma." Journal of Immunology 149, no. 1 (1992): 143–53. http://dx.doi.org/10.4049/jimmunol.149.1.143.

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Abstract The specificity and properties of a novel IgA receptor expressed on the surface of a tissue culture-adapted B cell lymphoma, T560, that originated in murine gut-associated lymphoid tissue, have been explored. Like the IgA receptors of murine T and splenic B cells studied by others, the T560 IgA receptor is trypsin sensitive and neuraminidase resistant and is up-regulated on T560 cells by exposing them overnight to high concentrations of polymeric IgA. Unlike them, the T560 IgA receptor is inhibited by low concentrations of IgM and high concentrations of IgG2a and IgG2b, binds at pH 4.

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DeCicco, Kathleen L., and A. Catharine Ross. "All-trans-retinoic acid and polyriboinosinoic : polyribocytidylic acid cooperate to elevate anti-tetanus immunoglobulin G and immunoglobulin M responses in vitamin A-deficient Lewis rats and Balb/c mice." Proceedings of the Nutrition Society 59, no. 4 (2000): 519–29. http://dx.doi.org/10.1017/s0029665100000756.

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Vitamin A (VA) deficiency compromises antibody responses to T-cell-dependent antigens such as tetanus toxoid, but this effect can be reversed through administration of retinol or retinoic acid (RA). To test whether RA and polyriboinosinioc : polyribocytidylic acid (PIC), a known inducer of several forms of interferon (IFN), can cooperate to increase specific immunoglobulin (Ig)G and IgM production during VA deficiency, rats and mice were made VA-deficient, immunized with TT and treated with all-trans-RA, PIC or their combination. VA-deficient rats produced low primary and secondary anti-tetanu

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Damle, Rajendra, Sonal Temburni, Tara Schaaf, et al. "Efficiency of BCR: Anti-BCR Interaction Dictates Cellular Outcomes of Signaling in Chronic Lymphocytic Leukemia Cells." Blood 112, no. 11 (2008): 3122. http://dx.doi.org/10.1182/blood.v112.11.3122.3122.

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Abstract Chronic lymphocytic leukemia is the most prevalent hematologic malignancy in the United States with over 10,000 new cases diagnosed every year. Several markers including Ig V gene mutation status, expression of CD38, ZAP-70 and CD49d, and chromosomal abnormalities associate closely with the biology of the clonal cancer cell and predict prognosis of the CLL patient. Since the demonstration that the degree of somatic mutations in Ig V genes impacts on the prognosis of CLL patients, several investigators have focused on understanding the functional relevance of the BCR expressed by CLL c

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