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1

Li, Hongchun, Yuan-Yu Chang, Lee-Wei Yang, and Ivet Bahar. "iGNM 2.0: the Gaussian network model database for biomolecular structural dynamics." Nucleic Acids Research 44, no. D1 (November 17, 2015): D415—D422. http://dx.doi.org/10.1093/nar/gkv1236.

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2

Yang, L. W., X. Liu, C. J. Jursa, M. Holliman, A. J. Rader, H. A. Karimi, and I. Bahar. "iGNM: a database of protein functional motions based on Gaussian Network Model." Bioinformatics 21, no. 13 (April 28, 2005): 2978–87. http://dx.doi.org/10.1093/bioinformatics/bti469.

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3

Mortari, F., S. Zlatanova, L. Liu, and E. Clementini. ""Improved Geometric Network Model" (IGNM): a novel approach for deriving Connectivity Graphs for Indoor Navigation." ISPRS Annals of Photogrammetry, Remote Sensing and Spatial Information Sciences II-4 (April 23, 2014): 45–51. http://dx.doi.org/10.5194/isprsannals-ii-4-45-2014.

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Over the past few years Personal Navigation Systems have become an established tool for route planning, but they are mainly designed for outdoor environments. Indoor navigation is still a challenging research area for several reasons: positioning is not very accurate, users can freely move between the interior boundaries of buildings, path network construction process may not be easy and straightforward due to complexity of indoor space configurations. Therefore the creation of a good network is essential for deriving overall connectivity of a building and for representing position of objects within the environment. This paper reviews current approaches to automatic derivation of route graphs for indoor navigation and discusses some of their limitations. Then, it introduces a novel algorithmic strategy for extracting a 3D connectivity graph for indoor navigation based on 2D floor plans.
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4

Nitschke, M., S. Mühlig, C. Altmann, and R. H. Strasser. "Ab igne ignem—Rauchen und Nichtrauchen in Sachsen." Prävention und Gesundheitsförderung 2, no. 1 (February 2007): 52–59. http://dx.doi.org/10.1007/s11553-006-0051-z.

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5

Morales, Ivonne, Kerstin D. Rosenberger, Tereza Magalhaes, Clarice N. L. Morais, Cynthia Braga, Ernesto T. A. Marques, Guilherme Amaral Calvet, et al. "Diagnostic performance of anti-Zika virus IgM, IgAM and IgG ELISAs during co-circulation of Zika, dengue, and chikungunya viruses in Brazil and Venezuela." PLOS Neglected Tropical Diseases 15, no. 4 (April 19, 2021): e0009336. http://dx.doi.org/10.1371/journal.pntd.0009336.

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Background Serological diagnosis of Zika virus (ZIKV) infection is challenging because of the antibody cross-reactivity among flaviviruses. At the same time, the role of Nucleic Acid Testing (NAT) is limited by the low proportion of symptomatic infections and the low average viral load. Here, we compared the diagnostic performance of commercially available IgM, IgAM, and IgG ELISAs in sequential samples during the ZIKV and chikungunya (CHIKV) epidemics and co-circulation of dengue virus (DENV) in Brazil and Venezuela. Methodology/Principal findings Acute (day of illness 1–5) and follow-up (day of illness ≥ 6) blood samples were collected from nine hundred and seven symptomatic patients enrolled in a prospective multicenter study between June 2012 and August 2016. Acute samples were tested by RT-PCR for ZIKV, DENV, and CHIKV. Acute and follow-up samples were tested for IgM, IgAM, and IgG antibodies to ZIKV using commercially available ELISAs. Among follow-up samples with a RT-PCR confirmed ZIKV infection, anti-ZIKV IgAM sensitivity was 93.5% (43/46), while IgM and IgG exhibited sensitivities of 30.3% (10/33) and 72% (18/25), respectively. An additional 24% (26/109) of ZIKV infections were detected via IgAM seroconversion in ZIKV/DENV/CHIKV RT-PCR negative patients. The specificity of anti-ZIKV IgM was estimated at 93% and that of IgAM at 85%. Conclusions/Significance Our findings exemplify the challenges of the assessment of test performance for ZIKV serological tests in the real-world setting, during co-circulation of DENV, ZIKV, and CHIKV. However, we can also demonstrate that the IgAM immunoassay exhibits superior sensitivity to detect ZIKV RT-PCR confirmed infections compared to IgG and IgM immunoassays. The IgAM assay also proves to be promising for detection of anti-ZIKV seroconversions in sequential samples, both in ZIKV PCR-positive as well as PCR-negative patients, making this a candidate assay for serological monitoring of pregnant women in future ZIKV outbreaks.
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6

Chae, Yura, Hye Eun Yoon, Yoon Kyung Chang, Young Soo Kim, Hyung Wook Kim, Bum Soon Choi, Cheol Whee Park, et al. "Renal Outcome of IgM Nephropathy: A Comparative Prospective Cohort Study." Journal of Clinical Medicine 10, no. 18 (September 16, 2021): 4191. http://dx.doi.org/10.3390/jcm10184191.

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Immunoglobulin M nephropathy (IgMN) is an idiopathic glomerulonephritis characterized by diffuse deposits of IgM in the glomerular mesangium. However, its renal prognosis remains unknown. We compared renal outcomes of IgMN patients with those of patients with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), or mesangial proliferative glomerulonephritis (MsPGN) from a prospective observational cohort, with 1791 patients undergoing native kidney biopsy in eight hospitals affiliated with The Catholic University of Korea between December 2014 and October 2020. IgMN had more mesangial proliferation and matrix expansion than MsPGN and more tubular atrophy and interstitial fibrosis than MCD. IgMN patients had decreased eGFR than MCD patients in the earlier follow-up. However, there was no significant difference in urine protein or eGFR among all patients at the last follow-up. When IgMN was divided into three subtypes, patients with FSGS-like IgMN tended to have lower eGFR than those with MCD-like or MsPGN-like IgMN but higher proteinuria than MsPGN-like IgMN without showing a significant difference. The presence of hypertension at the time of kidney biopsy predicted ≥20% decline of eGFR over two years in IgMN patients. Our data indicate that IgMN would have a clinical course and renal prognosis similar to MCD, FSGS, and MsPGN.
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7

Martins, Ives Gandra da Silva. "Improbidade administrativa e impeachment." RDAI | Revista de Direito Administrativo e Infraestrutura 1, no. 1 (June 30, 2017): 221–38. http://dx.doi.org/10.48143/rdai/01.igsm.

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Trata-se de estudo no qual o autor analisa os elementos subjetivos que envolvem os atos de improbidade administrativa, que podem levar ao impeachment do mau gestor público, abordando, assim, todas as formas de responsabilização tanto do Estado, quanto do agente público. Neste artigo, fica, pois, demonstrado, que os crimes contra a probidade da administração praticados pelo gestor público, sejam eles culposos ou dolosos, podem dar ensejo ao “impeachment”.
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8

Sidieu, Delphine, Allison Gilbert, Edmond Brasseur, Alexandre Ghuysen, and Vincent Orio. "Erythema ab igne and its association with cannabinoid hyperemesis syndrome : a case report." International Journal of Medical Reviews and Case Reports 3, Reports in Clinical Medicine (2019): 1. http://dx.doi.org/10.5455/ijmrcr.erythema-ab-igne.

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9

Chen, Kejia, Ping Chen, Lixi Yang, and Lian Jin. "Grey clustering evaluation based on AHP and interval grey number." International Journal of Intelligent Computing and Cybernetics 12, no. 1 (February 28, 2019): 127–37. http://dx.doi.org/10.1108/ijicc-04-2018-0045.

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PurposeThe purpose of this paper is to propose a grey clustering evaluation model based on analytic hierarchy process (AHP) and interval grey number (IGN) to solve the clustering evaluation problem with IGNs.Design/methodology/approachFirst, the centre-point triangular whitenisation weight function with real numbers is built, and then by using interval mean function, the whitenisation weight function is extended to IGNs. The weights of evaluation indexes are determined by AHP. Finally, this model is used to evaluate the flight safety of a Chinese airline. The results indicate that the model is effective and reasonable.FindingsWhen IGN meets certain conditions, the centre-point triangular whitenisation weight function based on IGN is not multiple-cross and it is normative. It provides a certain standard and basis for obtaining the effective evaluation indexes and determining the scientific evaluation of the grey class.Originality/valueThe traditional grey clustering model is extended to the field of IGN. It can make full use of all the information of the IGN, so the result of the evaluation is more objective and reasonable, which provides supports for solving practical problems.
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10

Afroz, Shireen, Maliha Alam Simi, Shanjida Sharmin, Laila Yeasmin, and LC Kundu. "Immunoglobulin m (IGM) Nephropathy in children - report of two cases." Journal of Dhaka Medical College 23, no. 1 (March 26, 2015): 131–33. http://dx.doi.org/10.3329/jdmc.v23i1.22709.

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Immunoglobulin M nephropathy (IgMN) is an idiopathic glomerulonephritis characterized by a variable degree of mesangialhypercellularity and diffuse IgM deposits.Patients usually presents with refractory nephrotic syndrome (NS) and hematuria. We present two patients with IgM nephropathy one with frequently relapsing NS with steroid dependence, treated with oral steroid and cyclophosphamide subsequently with tacrolimus. The patient showed complete remission but breakthrough relapses occurredduring the course of steroid treatment.The second case presented with persistentgross hematuria and nephroticrange proteinuria for 6 months. The patient showed complete remission of proteinuria and hematuria with oral steroid andremained on remission for9 months. Then again developed hematuria & proteinuria and subsequently showed response to oral steroid and cyclphosphamide . Renal histopathology & immunofluorescence study of first case revealed normal mesangial cellularity and basement membrane thickness with mesangial deposits of IgM. Second case showed global mesangial proliferation with increasing mesangial matrix with moderate mesangial deposits of IgM. DOI: http://dx.doi.org/10.3329/jdmc.v23i1.22709 J Dhaka Medical College, Vol. 23, No.1, April, 2014, Page 131-133
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11

Arslan, Hayriye, and Hüseyin Çetin. "Erythema Ab Igne." Journal of Turkish Family Physician 8, no. 2 (June 15, 2017): 40–42. http://dx.doi.org/10.15511/tjtfp.17.00240.

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12

Nadafi, Samira, Seyed Hamed Moosavirad, and Shahram Ariafar. "Predicting the project time and costs using EVM based on gray numbers." Engineering, Construction and Architectural Management 26, no. 9 (October 21, 2019): 2107–19. http://dx.doi.org/10.1108/ecam-07-2018-0291.

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PurposeThe purpose of this paper is to determine the project completion time and cost under non-deterministic conditions using interval gray numbers (IGNs).Design/methodology/approachThe earned value management (EVM) method based on the IGN has been developed.FindingsThe EVM method based on the IGN has been verified by a numerical example that can be applied to construction projects.Practical implicationsThe EVM method, based on the gray numbers, reduces the budget and time shortage risk. Also, using this method, the managers would not be restricted to provide very exact values in their progress reports in the non-deterministic conditions.Originality/valueOne notable and significant point in all projects during the execution process is to estimate the project completion time and cost. However, non-deterministic conditions for both planned and actual physical completion percentage of projects have not been considered for predicting the project completion time and cost in the literature. Therefore, the novelty of this paper is the prediction of project completion time and cost under non-deterministic conditions using IGN.
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13

Hearn, S., J. Walton, M. Moussa, Mark Rieckenberg, and K. Hutcheson. "Immunogold Labeling for Igg, Immunoglobulin Light Chains and P-Component in Fibrillary and Immunotactoid Glomerular Nephritis." Microscopy and Microanalysis 6, S2 (August 2000): 582–83. http://dx.doi.org/10.1017/s1431927600035406.

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Fibrillary and immunotactoid glomerulonephritis (FGN & IGN) are uncommon glomerular diseases, diagnosed by electron microscopic identification of fibril deposits which are negative by the Congo red stain. Micro-fibrils are similar to normal structures in glomerular basement membrane and matrix and they can be missed by EM. Pathogenesis of these glomerulopathies is unclear but they are not believed to be associated with monoclonal gammopathies as in AL amyloidosis. Immunofluorescense (IF) on FGN indicates the fibrils typically are positive for IgG and both immunoglobulin light chains while IGN fibrils are light chain monoclonal. We did immunogold labeling on four cases of FIGN in to improve the diagnosis of these diseases and investigate fibril protein composition.Renal biopsies from four patients consisted of one IGN and 3 FGN. Tests included frozen section IF (IgG, IgA, IgM, C3), paraffin section histology (Congo Red) and conventional EM (osmium fixation and epoxy embedding).
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14

Nesa, Nashreen, Tania Ghosh, and Indrajit Banerjee. "iGRM." ACM Transactions on Knowledge Discovery from Data 12, no. 4 (July 13, 2018): 1–23. http://dx.doi.org/10.1145/3186268.

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15

Scheurer, Louis, Rebecca R. Das Gupta, Annika Saebisch, Thomas Grampp, Dietmar Benke, Hanns Ulrich Zeilhofer, and Hendrik Wildner. "Expression of immunoglobulin constant domain genes in neurons of the mouse central nervous system." Life Science Alliance 4, no. 11 (August 25, 2021): e202101154. http://dx.doi.org/10.26508/lsa.202101154.

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General consensus states that immunoglobulins are exclusively expressed by B lymphocytes to form the first line of defense against common pathogens. Here, we provide compelling evidence for the expression of two heavy chain immunoglobulin genes in subpopulations of neurons in the mouse brain and spinal cord. RNA isolated from excitatory and inhibitory neurons through ribosome affinity purification revealed Ighg3 and Ighm transcripts encoding for the constant (Fc), but not the variable regions of IgG3 and IgM. Because, in the absence of the variable immunoglobulin regions, these transcripts lack the canonical transcription initiation site used in lymphocytes, we screened for alternative 5′ transcription start sites and identified a novel 5′ exon adjacent to a proposed promoter element. Immunohistochemical, Western blot, and in silico analyses strongly support that these neuronal transcripts are translated into proteins containing four Immunoglobulin domains. Our data thus demonstrate the expression of two Fc-encoding genes Ighg3 and Ighm in spinal and supraspinal neurons of the murine CNS and suggest a hitherto unknown function of the encoded proteins.
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16

Downey, Gerry. "Benoît Igne." NIR news 23, no. 4 (June 2012): 4–5. http://dx.doi.org/10.1255/nirn.1305.

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17

Koernig, Sandra, Ian K. Campbell, Charley Mackenzie-Kludas, Alexander Schaub, Marius Loetscher, Wy Ching Ng, Roland Zehnder, et al. "Topical application of human-derived Ig isotypes for the control of acute respiratory infection evaluated in a human CD89-expressing mouse model." Mucosal Immunology 12, no. 4 (May 19, 2019): 1013–24. http://dx.doi.org/10.1038/s41385-019-0167-z.

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AbstractRecurrent and persistent airway infections remain prevalent in patients with primary immunodeficiency (PID), despite restoration of serum immunoglobulin levels by intravenous or subcutaneous plasma-derived IgG. We investigated the effectiveness of different human Ig isotype preparations to protect mice against influenza when delivered directly to the respiratory mucosa. Four polyvalent Ig preparations from pooled plasma were compared: IgG, monomeric IgA (mIgA), polymeric IgA-containing IgM (IgAM) and IgAM associated with the secretory component (SIgAM). To evaluate these preparations, a transgenic mouse expressing human FcαRI/CD89 within the myeloid lineage was created. CD89 was expressed on all myeloid cells in the lung and blood except eosinophils, reflecting human CD89 expression. Intranasal administration of IgA-containing preparations was less effective than IgG in reducing pulmonary viral titres after infection of mice with A/California/7/09 (Cal7) or the antigenically distant A/Puerto Rico/8/34 (PR8) viruses. However, IgA reduced weight loss and inflammatory mediator expression. Both IgG and IgA protected mice from a lethal dose of PR8 virus and for mIgA, this effect was partially CD89 dependent. Our data support the beneficial effect of topically applied Ig purified from pooled human plasma for controlling circulating and non-circulating influenza virus infections. This may be important for reducing morbidity in PID patients.
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18

Mubarak, Muhammed, Javed I. Kazi, Shaheera Shakeel, Ali Lanewala, and Seema Hashmi. "The Spectrum of Histopathological Lesions in Children Presenting with Steroid-Resistant Nephrotic Syndrome at a Single Center in Pakistan." Scientific World Journal 2012 (2012): 1–5. http://dx.doi.org/10.1100/2012/681802.

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Steroid-resistant nephrotic syndrome (SRNS) is a common problem in pediatric nephrology practice. There is currently little information in the literature on the spectrum of histopathologic lesions in children presenting with SRNS in Pakistan. This study was designed to determine the histopathologic lesions in children presenting with SRNS at our center. The study was conducted at the Histopathology Department, Sindh Institute of Urology and Transplantation (SIUT) from January 2009 to August 2011. All children (≤16 years) presenting with SRNS, in whom renal biopsies were performed, were included. Their demographic, clinical, laboratory, and histopathological data were retrieved from files and original renal biopsy forms. The results were analyzed by SPSS version 10.0. A total of 147 children were included. Of these, 91 (61.9%) were males and 56 (38.1%) females, with male-to-female ratio of 1.6 : 1. The mean age was 7.03 ± 4.0 years (range: 6 months–16 years). The histopathological lesions seen on renal biopsies comprised of focal segmental glomerulosclerosis (FSGS) (38.5%), followed by minimal change disease (MCD) (23.2%), IgM nephropathy (IgMN) (13.6%), idiopathic mesangial proliferative GN (10.2%), membranous GN (8.2%), and mesangiocapillary GN (4.8%). Our results indicate that FSGS is the predominant lesion in children with SRNS, followed by MCD and IgMN.
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19

Smith, Thomas, and Vinod E. Nambudiri. "Erythema ab igne." Cleveland Clinic Journal of Medicine 85, no. 2 (February 2018): 96–97. http://dx.doi.org/10.3949/ccjm.85a.17015.

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20

Gyöngyössy, Orsolya, and Judit Daróczy. "Erythema ab igne." Bőrgyógyászati és Venerológiai Szemle 89, no. 5 (October 30, 2013): 127–32. http://dx.doi.org/10.7188/bvsz.2013.89.5.3.

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21

Weidringer, Walter. "IGNM-Fest." Österreichische Musikzeitschrift 62, no. 11-12 (January 2007). http://dx.doi.org/10.7767/omz.2007.62.1112.57.

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"IGNM-Forum." Österreichische Musikzeitschrift 40, no. 1 (January 1985). http://dx.doi.org/10.7767/omz.1985.40.1.56.

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"IGNM-FORUM." Österreichische Musikzeitschrift 40, no. 10 (January 1985). http://dx.doi.org/10.7767/omz.1985.40.10.552.

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"IGNM-Forum." Österreichische Musikzeitschrift 40, no. 2-3 (January 1985). http://dx.doi.org/10.7767/omz.1985.40.23.124.

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"IGNM-Forum." Österreichische Musikzeitschrift 40, no. 4 (January 1985). http://dx.doi.org/10.7767/omz.1985.40.4.200.

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"IGNM-Forum." Österreichische Musikzeitschrift 40, no. 5 (January 1985). http://dx.doi.org/10.7767/omz.1985.40.5.262.

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"IGNM-Forum." Österreichische Musikzeitschrift 40, no. 6 (January 1985). http://dx.doi.org/10.7767/omz.1985.40.6.330.

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"IGNM-Forum." Österreichische Musikzeitschrift 40, no. 9 (January 1985). http://dx.doi.org/10.7767/omz.1985.40.9.494.

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"IGNM-FORUM." Österreichische Musikzeitschrift 41, no. 1 (January 1986). http://dx.doi.org/10.7767/omz.1986.41.1.52.

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"IGNM-Forum." Österreichische Musikzeitschrift 41, no. 10 (January 1986). http://dx.doi.org/10.7767/omz.1986.41.10.534.

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"IGNM-FORUM." Österreichische Musikzeitschrift 41, no. 11 (January 1986). http://dx.doi.org/10.7767/omz.1986.41.11.598.

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"IGNM-Forum." Österreichische Musikzeitschrift 41, no. 12 (January 1986). http://dx.doi.org/10.7767/omz.1986.41.12.668.

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"IGNM-Forum." Österreichische Musikzeitschrift 41, no. 2 (January 1986). http://dx.doi.org/10.7767/omz.1986.41.2.112.

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"IGNM-Forum." Österreichische Musikzeitschrift 41, no. 3-4 (January 1986). http://dx.doi.org/10.7767/omz.1986.41.34.190.

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"IGNM-FORUM." Österreichische Musikzeitschrift 41, no. 6 (January 1986). http://dx.doi.org/10.7767/omz.1986.41.6.330.

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"IGNM-Forum." Österreichische Musikzeitschrift 41, no. 7-8 (January 1986). http://dx.doi.org/10.7767/omz.1986.41.78.402.

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"IGNM-Forum." Österreichische Musikzeitschrift 41, no. 9 (January 1986). http://dx.doi.org/10.7767/omz.1986.41.9.476.

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"IGNM-Forum." Österreichische Musikzeitschrift 42, no. 1 (January 1987). http://dx.doi.org/10.7767/omz.1987.42.1.54.

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"IGNM-Forum." Österreichische Musikzeitschrift 45, no. 2 (January 1990). http://dx.doi.org/10.7767/omz.1990.45.2.119.

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"IGNM-Forum." Österreichische Musikzeitschrift 42, no. 7-8 (January 1987). http://dx.doi.org/10.7767/omz.1987.42.78.400.

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"IGNM-Forum." Österreichische Musikzeitschrift 46, no. 3-4 (January 1991). http://dx.doi.org/10.7767/omz.1991.46.34.189.

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"IGNM-Forum." Österreichische Musikzeitschrift 40, no. 11 (January 1985). http://dx.doi.org/10.7767/omz.1985.40.11.620.

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"IGNM-Forum." Österreichische Musikzeitschrift 40, no. 7-8 (January 1985). http://dx.doi.org/10.7767/omz.1985.40.78.418.

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"IGNM-Forum." Österreichische Musikzeitschrift 42, no. 12 (January 1987). http://dx.doi.org/10.7767/omz.1987.42.12.628.

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"IGNM-Forum." Österreichische Musikzeitschrift 42, no. 2-3 (January 1987). http://dx.doi.org/10.7767/omz.1987.42.23.126.

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"IGNM-Forum." Österreichische Musikzeitschrift 42, no. 4 (January 1987). http://dx.doi.org/10.7767/omz.1987.42.4.194.

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"IGNM-Forum." Österreichische Musikzeitschrift 42, no. 5 (January 1987). http://dx.doi.org/10.7767/omz.1987.42.5.260.

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"IGNM-Forum." Österreichische Musikzeitschrift 42, no. 6 (January 1987). http://dx.doi.org/10.7767/omz.1987.42.6.324.

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"IGNM-Forum." Österreichische Musikzeitschrift 42, no. 9 (January 1987). http://dx.doi.org/10.7767/omz.1987.42.9.474.

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"IGNM-FORUM." Österreichische Musikzeitschrift 43, no. 1 (January 1988). http://dx.doi.org/10.7767/omz.1988.43.1.52.

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