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Spink, Charlotte Fiona. "Genotyping and haplotyping using induced heteroduplex generators (IHG) : design aspects, automation and application to cytokine profiling in B cell lymphoproliferative diseases." Thesis, University of the West of England, Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418226.
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Minet, Antoine. "Bioaccumulation and effects of mercury in cuttlefish in the context of ocean acidification." Electronic Thesis or Diss., La Rochelle, 2022. http://www.theses.fr/2022LAROS039.
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La seiche commune, Sepia officinalis, est un céphalopode côtier connu pour ses performances écophysiologiques soutenues par un large répertoire de comportements lui permettant, malgré son cycle de vie court, de tenir un rôle central dans les réseaux trophiques. Cependant, elle est également connue pour accumuler efficacement les éléments métalliques tel que le mercure (Hg), un contaminant neurotoxique sous sa forme organique (methylmercure ; MeHg). De plus, dans le contexte des changements environnementaux globaux, l’acidification des océans (AO) induite par l’augmentation des émissions de CO2, peut impacter le métabolisme, le développement et le système nerveux central, notamment chez les jeunes stades de vie. Le présent travail a donc pour but d’étudier les effets de l’AO sur la bioaccumulation du Hg et les effets de ces deux neurotoxiques (Hg et CO2) sur le comportement et les performances cognitives chez les juvéniles de seiches. Préalablement, des mesures in-situ ont montré que le Hg s’accumulait dans le cerveau des céphalopodes sous forme méthylé (MeHg). Par ailleurs, les approches expérimentales utilisant des traceurs isotopiques (stables et radioactif) du Hg ont démontré que l’accumulation du Hg total provenait majoritairement de l’assimilation du MeHg présent dans les proies, en comparaison à l’accumulation du mercure inorganique (iHg) par voie dissoute. Ce MeHg est ensuite très fortement retenu malgré la mise en évidence de processus de déméthylation du Hg dans la glande digestive. Étonnamment, l’AO n’a aucun effet sur les efficacités de la bioaccumulation et le métabolisme du Hg. En termes d’effets, des essais comportementaux ont montré que le Hg et CO2, seuls ou combinés, n’impactaient pas l’acuité visuelle et les performances de prédation chez les juvéniles. Par contre, ces deux derniers induisent une augmentation de l’activité locomotrice, compromettant le comportement défensif à travers notamment une altération de la coloration disruptive et un non-alignement de la latéralisation. Parmi les processus neuronaux susceptibles d’être impactés par le Hg et le CO2, le système GABAergique a été analysé dans les lobes optiques mais n’a montré aucun lien évident avec les réponses comportementales suggérant des processus d’effets plus complexes. L’ensemble de ce travail questionne donc les effets des conditions futures de l’océan sur les juvéniles de seiches, et plus largement les impacts sur les populations de céphalopodes<br>The common cuttlefish, Sepia officinalis, is a coastal cephalopod known for its eco physiological performance supported by a wide repertoire of behaviors that allows it, despite its short life cycle, to play a central role in food webs. However, it is also known to efficiently accumulate metallic elements such as mercury (Hg), a neurotoxic contaminant in its organic form (methylmercury; MeHg). Moreover, in the context of global changes, ocean acidification (OA) induced by the increase of CO2 emissions, can impact metabolism, development and the central nervous system, especially in young life stages. The present work therefore aims to study the effects of OA on Hg bioaccumulation and the effects of these two neurotoxicants (Hg and CO2) on behavior and cognitive performance in juvenile cuttlefish. In the first place, in-situ measurements showed that Hg accumulated in the brain of cephalopods in methylated form (MeHg). Moreover, experimental approaches using isotopic tracers (stable and radioactive) of Hg have shown that the accumulation of total Hg comes mainly from the assimilation of MeHg present in preys, compared to the accumulation of inorganic mercury (iHg) dissolved in seawater. This MeHg is then very strongly retained despite evidence of Hg demethylation processes in the digestive gland. Surprisingly, OA has no effect on the bioaccumulation efficiencies and metabolism of Hg. In terms of effect, behavioral assays showed that Hg and CO2, alone or in combination, did not impact visual acuity and predation performance in juveniles. However, both induced an increase in locomotor activity, compromised defensive behavior through, in particular, an alteration of disruptive coloration and a non-alignment of lateralization. Among the neural processes likely to be impacted by Hg and CO2, the GABAergic system was analyzed in the optic lobes but showed no obvious link with behavioral responses suggesting more complex effect processes. All of this work therefore questions the effects of future ocean conditions on juvenile’s cuttlefish, and more broadly the impacts on cephalopod populations
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Bruhn, Elisa [Verfasser]. "Virtual Internationalization in Higher Education / Elisa Bruhn." Bielefeld : wbv Media, 2020. http://wbv.de/ihs.
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Kauther, Ralf. "Hegels Dialektik : ihr Anfang, ihre Methode, ihr Ziel /." Köln : R. Kauther, 1998. http://catalogue.bnf.fr/ark:/12148/cb39174227s.
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Krüger, Hartmut. "Frauen im Pietismus : ihr Dienst, ihre Verantwortung, ihr Einfluss." Marburg an der Lahn Francke, 2005. http://deposit.ddb.de/cgi-bin/dokserv?id=2668119&prov=M&dokv̲ar=1&doke̲xt=htm.
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Daly, J. N. "IgH allelic exclusion at the level of IgH transcription." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598257.
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Expression of a productivity rearranged immunoglobulin heavy (μH) chain from a first in-frame VDJ<sub>H</sub>-rearranged allele prevents further recombinant of the second, DJ<sub>H</sub>-rearranged, allele, termed heavy chain allelic exclusion. I investigated at the single cell level the transcriptional status of both <i>IgH</i> alleles in <i>ex vivo </i>cells using RNA fluorescent <i>in situ</i> hybridisation (FISH). Prior to exclusion, in predominantly DJ<sub>H </sub>/DJ<sub>H</sub>-rearranged pro/pre-B1 cells, both IgH alleles are transcribed and detected by RNA-FISH. In contrast, following productive VDJ<sub>H</sub>-recombination and μH expression i.e. in allelically excluded pre-BII cells, mono-allele transcription was detected in the 40% and bi-allelic in 60% of cells. This 40:60 ratio was maintained throughout subsequent B cell developmental stages. A V<sub>H</sub>-specific transcription assay revealed a V<sub>H </sub>(J558) transcription co-localising with mono- and bi-allelic μ transcription sites, strongly indicating transcription from VDJ<sub>H</sub>-rearranged alleles in allelically excluded B cells. Combined RNA/DNA FISH showed detection of the V<sub>H</sub>-D<sub>H </sub>intergenic regions in cells with mono-allelic μ-transcription. Within these nuclei the μ-transcription site and V<sub>H</sub>-D<sub>H</sub> intergenic region were clearly separate and thus do not originate from the same allele, thus suggesting a VDJ<sub>H</sub>/DJ<sub>H</sub>-rearrangement status. In the majority (>80%) of nuclei with two μ-transcription sites no V<sub>H</sub>-D<sub>H</sub>-intergenic regions were observed, suggesting VDJ<sub>H</sub>/VDJ<sub>H</sub>-recombination. Semi-quantitative RT-PCR revealed steady-state DJ<sub>H</sub>-Cμ transcripts in splenic B cells, which have been allelically excluded at levels 2-3 fold less than observed in a developmental stage prior to exclusion. Thus the DJ<sub>H</sub>-recombined allele is transcribed after exclusion. Our data show that the process of allelic exclusion results in diminished ability for RNA-FISH to detect the transcription of the DJ<sub>H</sub>- but not the VDJ<sub>H</sub>-rearranged alleles, indicating that the signal for allelic exclusion is received only by the DH<sub>J</sub>-recombined alleles. Therefore, in allelically excluded cells, the DJ<sub>H</sub>-but not VDJ<sub>H</sub>-rearranged alleles alter their transcriptional activity and thus act as part of the mechanism for heavy chain allelic exclusion.
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Sartori, Viviane. "InHab-Read - IHR." reponame:Repositório Institucional da UFSC, 2017. https://repositorio.ufsc.br/xmlui/handle/123456789/180897.
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Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia e Gestão do Conhecimento, Florianópolis, 2017.<br>Made available in DSpace on 2017-11-14T03:21:56Z (GMT). No. of bitstreams: 1
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Previous issue date: 2017<br>Os habitats de inovação são empreendimentos organizados sistematicamente para promover a inovação, propiciando a interação e a integração de diferentes atores. São fenômenos contemporâneos de grande relevância para o desenvolvimento de uma região ou de um país, pois operam com ativos de conhecimento. A implantação de um habitat de inovação implica, diretamente, no desenvolvimento socioeconômico e cultural da comunidade de seu entorno. Estes oferecem condições diferenciadas para desenvolver produtos e processos inovadores, com o propósito de fomentar as dinâmicas econômicas e sociais, locais e regionais, uma vez que tem a capacidade de reunir pessoas, tecnologias, recursos financeiros e conhecimento. A problemática levantada para esta pesquisa trata de como analisar as comunidades do entorno dos habitats de inovação em relação às suas necessidades, potencialidades e expectativas. O lastro teórico para esta tese está construído na intersecção entre os conceitos de habitats de inovação, parques tecnológicos, inovação, inovação social, tríplice e quádrupla hélice. O objetivo é elaborar uma metodologia para leitura e análise identificando, necessidades, potencialidades e expectativas das comunidades do entorno dos habitats de inovação. Esta pesquisa caracteriza-se como exploratória descritiva. Desenvolve-se a partir de uma revisão sistemática para levantar os conceitos básicos e um benchmarking para identificar práticas de leitura de entorno. Com estes elementos propõe-se uma metodologia de leitura de entorno desenvolvida em três fases: elaboração, prototipagem e aplicação. A elaboração constituiu-se em um instrumento online, que foi prototipada no entorno do Orion Parque, na cidade de Lages. A aplicação da metodologia para sua conformação foi feita no entorno do Sapiens Parque, em Florianópolis. Os atores envolvidos nesse processo foram gestores de 8 parques tecnológicos visitados, 10 gestores de organizações internas do Sapiens Parque, 201 gestores de organizações externas e 622 famílias situadas no entorno do Sapiens Parque. O resultado alcançado com este estudo foi a conformação de uma proposta metodológica adaptável para diferentes tipos de habitats de inovação, que possibilita realizar a leitura e a análisedo entorno desses empreendimentos, gerando informações que caracterizam o perfil da população local em relação às suas necessidades, potencialidades e expectativas. Com a aplicação da InHab-Read ? IHR ? Metodologia de leitura de entorno para habitats de inovação é possível orientar políticas e ações conjuntas entre a população do entorno e as organizações internas dos habitats, potencializando a interação entre todos os atores, e ampliando as dimensões dos processos de inovação tecnológica e econômica para a inovação social.<br>Abstract : Innovation habitats are systematically organized enterprises to promote innovation and provide the interaction and integration of different actors. They are contemporary phenomena of high relevance for the development of a region or a country because they operate with knowledge assets. The implementation of an innovation habitat directly implies the socioeconomic and cultural development of the surrounding community. These provide differentiated conditions for developing innovative processes and products to foster economic, social, local and regional dynamics as it can bring together people, technologies, financial resources, and knowledge. The issue regarding this research analyzes the communities surrounding the innovation habitats about their needs, potentialities, and expectations. The theoretical background for this thesis is built on the intersection between concepts of innovation habitats, technology parks, changes, social innovation, triple and quadruple propeller. The aim is to develop a methodology for reading and analysis, identifying needs, potentialities, and expectations of communities surrounding the innovation habitats. The study is characterized as descriptive and exploratory. It develops from a systematic review to obtain basic concepts and a benchmarking to identify surrounding reading practices. With such elements, it is proposed a methodology of environment interpretation developed in three phases: elaboration, prototyping, and application. The elaboration was constituted by an online instrument that was prototyped in the Orion Park?s surrounding, in the city of Lages. The methodology application for its configuration was developed in the Sapiens Park?s surrounding, in Florianópolis. The actors involved in the process were eight managers of the technological parks visited, ten managers of internal organizations of the Sapiens Parque, 201 managers of external companies and 622 families located around the Sapiens Parque. The result obtained with the study relates to an adaptive methodological proposal for different types of innovation habitats, which makes it possible to read and analyze the enterprises? surroundings, generating information that characterizes thelocal population profile regarding their needs, potentialities, and expectations. With the application of InHab-Read - IHR - Environment Reading Methodology for innovation habitats, it is possible to propose common policies and actions between the surrounding population and habits internal organizations, enhancing the interaction among all the actors, and broadening dimensions of technological and economic innovation processes for social change.
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Säll, El Kebich Amina. "Adverbial ing-clauses and non-ing initial adverbials in medical translation." Thesis, Linnéuniversitetet, Institutionen för språk (SPR), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-97954.
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This study investigates how non-ing initial adverbials and adverbial ing-clauses regardless of position are translated from English to Swedish in a medical text. It discusses what different kinds of positions and forms they take in the translation. The primary source is a medical text that is translated wherein the non-ing initial adverbials and adverbial ing-clauses are identified and categorized, and solutions are discussed. The results show that most non-ing initial adverbials keep their form, but are changed in some cases because of stylistic preferences. The most common form of the non-ing initial adverbials is prepositional phrases that mostly also are translated as prepositional phrases. The adverbial ing-clauses, regardless of position, change their form in all cases in the translation and the most common correspondence is subordination. Both non-ing initial adverbials and adverbial ingclauses keep their position in most cases, but are sometimes moved due to stylistic preferences.
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Hoechtl, Nina. "If only for the length of a lucha : queer/ing, mask/ing, gender/ing and gesture in lucha libre." Thesis, Goldsmiths College (University of London), 2012. http://research.gold.ac.uk/8056/.
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This PhD uses a queer reading strategy to explore the performative sites of lucha libre (wrestling in Mexico). My research inhabits the space behind the scene, the space between the ring and the audience, and the space of being part of the audience itself. My reading of the luchas takes place through the camera, the interview, printed works, theoretical investigation, and through the work of artists who draw on lucha libre – including myself. As lucha libre itself cannot be narrowed down to one specific medium, my subject matter allows me to utilize an interdisciplinary perspective to examine its various encounters, spaces, subjectivities and gestures. As well as attending live events in the arenas, watching lucha libre on television, exploring its circulation in artistic and filmic productions and its appropriation in advertisements and political discourse, I have carried out an intervention in a regular lucha libre programme by inventing a character, promoting, constructing and staging a match in an arena in the north of Mexico City. My methodology therefore makes use of a whole range of strategies including those borrowed from the discipline of anthropology and from practices of documentary making. Through my writing and my practice, I attempt to query and complicate these disciplinary conventions and my own use of them. I place particular emphasis in this PhD upon the possibility and use of a queer reading strategy in relation to lucha libre. Drawing on the works of Gloria Anzaldúa, Judith Butler, Judith ʻJackʼ Halberstam, José Javier Maristany, and José Esteban Muñoz, the thesis argues that a queer reading strategy has the potential to complicate ways of seeing gender and sexuality as well as race, ethnicity, class, time and space in this context. I identify the rich queer legacies within lucha libre, film and popular culture, and focus on the multiple and often conflicting readings made possible by adopting queer theory and reading practices. In doing so, the thesis interrogates the different ways in which popular cultures can go beyond accepted notions of what it means to be Mexican, a woman, macho, gay and so on. Throughout this work, I pay close attention to forms of audience participation, their verbal and gestural acts and how key these are in to the event of the lucha. These verbal and gestural acts, I argue, produce a unique complicity in the arena manifesting a transient trace of queer histories, and suggesting potential utopias.
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Rechenberg, Ingo. "Evolutionsstrategie '94 /." Stuttgart : Frommann-Holzboog, 1994. http://www3.ub.tu-berlin.de/ihv/000219248.pdf.
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Steinbach, Jörg. "Chemische Sicherheitstechnik /." Weinheim ; New York ; Basel ; Cambridge ; Tokyo : VCH, 1995. http://www3.ub.tu-berlin.de/ihv/000261483.pdf.
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Zugl.: Berlin, Techn. Universiẗat, Habil.-Schr., 1994 u.d.T.: Steinbach, Jörg: Theoretische Untersuchungen reaktionstechnischer Probleme in der Syntheseoptimierung und der chemischen Sicherheitstechnik.
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Flecke, Ursula. "Zur Genese der Nachmoderne im Städtebau : Entwürfe 1960 - 1975 in Westdeutschland /." Berlin : Techn. Univ., Univ.-Bibliothek, Abt. Publ, 1999. http://www3.ub.tu-berlin.de/ihv/000568903.pdf.
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Dehrendorf, Martin Heiss Michael. "Geo-Informationssysteme in der kommunalen Planungspraxis /." Norden ; Halmstad : Points-Verl, 2004. http://www3.ub.tu-berlin.de/ihv/000945955.pdf.
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Windeler, Arnold. "Unternehmungsnetzwerke : Konstitution und Strukturation /." Wiesbaden : Westdt. Verl, 2002. http://www3.ub.tu-berlin.de/ihv/001719509.pdf.
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Naredi-Rainer, Paul von. "Architektur und Harmonie : Zahl, Mass und Proportion in der abendländischen Baukunst /." Köln : DuMont, 2001. http://www3.ub.tu-berlin.de/ihv/000870583.pdf.
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Quijoux, Maxime Zagefka Polymnia Cosío-Zavala María-Eugenia. "Destins féminins, genre et autogestion dans une usine récupérée d'Argentine." [S. l.] : [s. n.], 2005. http://www.credal.univ-paris3.fr/IMG/pdf/MemoireDEAmaximeQuijoux.pdf.
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Mazars, Nadège Gros Christian. "Mouvement indigène en Equateur." [S. l.] : [s. n.], 2005. http://www.iheal.univ-paris3.fr/IMG/pdf/DEA_v1_N_Mazars.pdf.
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Keller, Andreas. "Michael Kongehl (1646-1710) : Durchwandert ihn/gewiss ! Ihr werdet anders werden... : transitorische Textkonstitution und persuasive Adressatenlenkung auf der Basis rhetorischer Geneseprinzipien im Gesamtwerk des Pegnitzschäfers in Preussen /." Berlin : Weidler, 2004. http://catalogue.bnf.fr/ark:/12148/cb414689150.
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Fung, Tak-kit. "Teaching the -ing forms." Click to view the E-thesis via HKUTO, 1986. http://sunzi.lib.hku.hk/HKUTO/record/B38626408.
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Fung, Tak-kit, and 封德傑. "Teaching the -ing forms." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1986. http://hub.hku.hk/bib/B38626408.
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Bodman, Katherine Birgitta. "IgG glycoforms in arthritis." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283129.
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Zhang, Gaiping. "Bovine IgG Fc receptors." Thesis, University of Hertfordshire, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387187.
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Ziegler, Jochen. "refin [d]ing process." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/35586.
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This thesis marks a point where the priorities determining my occupation with architecture might shift.
In part it is a reflection of an approach to architecture, which generates an awareness that can be extended to an environment of practice. This awareness should provide direction towards the making of architecture, regardless to the number of constraints or limitations which reality might impose.
This project is the documenting vehicle for the examination of a design process.
The proposal is the evidence of this design process. Its documentation should prove and expose qualities which derived from my approach to architecture.<br>Master of Architecture
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Drozd, Natalia. "Tailbone-ing movement practice." Thesis, Stockholms konstnärliga högskola, Institutionen för dans, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uniarts:diva-916.
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The main purpose of the essay is to serve as a documentation of my research practice on the movement of the tailbone and its connections to my dancing body. The essay is being written from my personal perspective which springs out of my interest in the importance of using the tailbone whilst dancing. In the first part of the text I have included personal information to the reader about where my interest in the movement of the tailbone arose. One of the methods during the research was to write a process diary as a way to combine a physical practice and writing practice. This process diary is now a big part of this essay. In the essay you as a redear can follow how the research has transformed and changed throughout working time on the project. The second part of the essay reflects on the process of researching the tailbone-ing movement practice and what the practical presentation should look like. In the last pages of the essay you find a choreographic score which is both a documentation of the practice as well as a score to perform it. Working on the essay opens up new possibilties for further research on the importance of the tailbone and the pelvic floor in the dancing body.<br><p>This master work includes both a performing and a written part. </p>
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Sterk, Sabine. "Wunderheilmittel - und ihr Kommunikationsverhalten." [S.l. : s.n.], 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11612072.
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Neumann-Hartmann, Arlette. "Epinikien und ihr Aufführungsrahmen." Hildesheim Weidmann, 2007. http://d-nb.info/99416906X/04.
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Pourabadeh, J. "Analysis of IDG discontinuities." Thesis, University of Bath, 1998. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266472.
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Martin, Susanne. "Dancing age(ing) : rethinking age(ing) in and through improvisation practice and performance." Thesis, Middlesex University, 2016. http://eprints.mdx.ac.uk/18984/.
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Set in the context of contemporary dance this thesis investigates how improvisation practice and performance making participate in a critical rethinking of age(ing). Advancing the notion of an age critical dance practice, the research draws on the theoretical frameworks of age studies – a multidisciplinary field of critical inquiry informed by, largely speaking, feminist and poststructuralist theories. The age critical dance practice developed in this thesis, in turn, enters into conversation with the discourses established in age studies and dance studies as a way to incorporate age critique into dance. The thesis is a Practice as Research project consisting of a written thesis, two solo performances (The Fountain of Youth, premiered 2013, and The Fountain of Age, premiered 2015), and employs immersive dance based research methods such as the development of a Solo Partnering practice (as documented on DVD). The research also remodels the method of qualitative interviewing into a performative method that allows the participating expert practitioners to tap into their unique improvisation and performance expertise when addressing their particular understanding of age(ing). Through the development and analysis of improvised practice and performance making, alongside in-depth performative interviews, the findings of this research point to ways in which improvisation and performance embody age critical potential. The long-term, open-ended and agentic artistic processes that improvisation experts develop all share a range of characteristics that serve to challenge the established youth-orientation in dance and constitute an implicitly critical position to dominant understandings of age(ing) in dance. Consequently, the thesis argues that improvisation practices ‘do’ age(ing) in ways less prone to dualistic stereotyping and reiterations of (self‐) discriminatory age(ing)-as‐decline narratives that dominate our culture as a whole. The research also suggests strategies in performance making that enable representations of age(ing) in ways that collide with, resist, or complicate normative expectations on age(ing). The dance works presented in this thesis allow the dancer to articulate shifting perspectives and experiences, creating ambiguous meanings and disjunctive narratives of age(ing), and thereby making explicit a critical position towards the grand narratives of age(ing). In conclusion, this research argues that specific approaches to a long-term, open-ended dance practice, alongside critical images and new imaginations of age(ing) in performance, allow dance to evolve as an age critical arts practice.
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Redpath, Stella. "Effector functions of human IgG." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363193.
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Harbek, Josefine. "Die Liebe und ihr Feind." Alexander Fuchs, 2012. https://slub.qucosa.de/id/qucosa%3A16294.
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Roman über die Zeit des Nationalsozialismus in Dresden
In der Nacht zum Aschermittwoch 1945 zerstörten britische und amerikanische Bomber die Innenstadt von Dresden. Mehrere zehntausend Einwohner kamen dabei ums Leben. Tage und Nächte lang brannte die Stadt. Die das Inferno überlebten, hatten all' ihr Hab und Gut oder - schlimmer noch - jene Menschen verloren, die sie über alles liebten und von denen sie geliebt worden waren. Dieser Roman spielt in der Zeit bis zu jener Katastrophe und schildert das Leben einer Gruppe junger Menschen, die nicht ahnen, welches Unheil sich über ihnen zusammenbraut.
Dieser Roman ist Band 06 der 'Kleinen Werkeausgabe' von Alexander Fuchs.
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Marvanová, Zuzana. "Analýza společenské odpovědnosti firmy ING." Master's thesis, Vysoká škola ekonomická v Praze, 2010. http://www.nusl.cz/ntk/nusl-74057.
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Thesis contains basic informations and definitions of CSR, its history, contemporary activities and main advantages as well as disadvantages. Except that are described possibilities of implementation, measurement and evaluation of it in a company. The second part is concerned with the attitude of ING to corporate social responsibility globally as well as in Czech republic. At the end is a short questionnaire.
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Heidenhain, Brigitte. "Juden in Wriezen : ihr Leben in der Stadt von 1677 bis 1940 und ihr Friedhof." Universität Potsdam, 2007. http://opus.kobv.de/ubp/volltexte/2007/1519/.
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Pri ha-Pardes (Früchte des Obstgartens) ist eine Reihe der Vereinigung für Jüdische Studien e.V., welche in Verbindung mit dem Zentrum für Jüdische Studien der Universität Potsdam publiziert wird. Pri ha-Pardes möchte kleineren wissenschaftlichen Studien, Forschungen am Rande der großen Disziplinen und exzellenten Masterarbeiten eine Publikationsplattform bieten.
Im ersten Band dieser Reihe zeichnet Brigitte Heidenhain die Geschichte der Juden in Wriezen nach, welche 1677 einsetzte und 1940 mit ihrer Vertreibung und Ermordung endete.
Zahlreiche, zumeist bislang unbeachtete Quellen des 18. und 19. Jahrhunderts aus brandenburgischen und Berliner Archiven lassen die Auswirkungen der preußischen Judenpolitik im Leben des Einzelnen und der Gemeinde lebendig vor uns erstehen. Im 18. Jahrhundert war die Existenz der Wriezener Juden vom Kampf um die Aufenthaltserlaubnis und gegen drohende Verarmung geprägt. Die im 19. Jahrhundert neu gewonnene Niederlassungsfreiheit brachte eine Vergrößerung der jüdischen Gemeinde mit sich und gegen Ende des Jahrhunderts eine leichte Verbesserung der wirtschaftlichen Lage.
Über das schnelle und vollständige Ende jüdischen Lebens in Wriezen nach 1938 gibt es kaum schriftliche Informationen. Die wichtigste Quelle ist die Datenbank der Gedächtnisstätte JadwaSchem in Jerusalem. In ihr wird die Erinnerung an 56 namentlich bekannte ermordete Wriezener Juden aufbewahrt.
Der Band wird mit der Beschreibung des seit 1730 existierenden jüdischen Friedhofes und der Erfassung der hebräischen Grabinschriften abgeschlossen.<br>The history of jews in Wriezen begins in 1677, shortly after Kurfürst Friedrich Wilhelm allowed jews to settle in Brandenburg again through his edict of 1671. However, during the whole of the 18th century Prussian policy toward jews was extremely restrictive . The results of this policy are clearly visible in the life of the jews of Wriezen: they always remained a small congregation since this was the will of the king for small towns. Life was dominated by the struggle for the right of residence. Status as "Schutzjude" (i.e. "Protected Jew") was restricted to few individuals, leading to the separation of families as younger siblings were forced to leave. State regulated economic policy strongly restricted the freedom of trade, the main source of income for the jews, leading to the impoverishment of most jewish families in Wriezen. In the 18th century, there was no organized congregational activity. This only developed in the course of the 19th century. The jews of Wriezen built their first synagogue in 1820, replacing it with a new and larger one in 1886. The emancipation edict of 1812 improved the general situation of individuals and the new freedom of movement led to an influx of jews to Wriezen. But full legal equality with other citizens was not achieved until the German Empire was founded in 1871. In the first half of the 19th century, the economic situation of the jews of Wriezen was still quite modest, only improving toward the end of the century. There were numerous fluctuations in the membership of the jewish community in the last decades of the 19th and the beginning of the 20th century. But the number of jewish inhabitants of Wriezen remained relatively constant at 100 -120 individuals. There is hardly any written information on the sudden and complete end of jewish life in Wriezen after 1938. At least 59 jewish citizens of Wriezen were deported and murdered between 1940 and 1945. The victims are commemorated in the public database of the Yad-VaShem Memorial in Jerusalem. There has been a jewish cemetery in Wriezen since 1730, in which 131 gravestones still survive today. The oldest dates back to 1773, the last is from 1940.
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Heidenhain, Brigitte. "Juden in Schwedt : ihr Leben in der Stadt von 1672 bis 1942 und ihr Friedhof." Universität Potsdam, 2010. http://opus.kobv.de/ubp/volltexte/2010/4158/.
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270 Jahre lang gab es jüdisches Leben in der brandenburgischen Stadt Schwedt an der Oder. Der Leser dieses Bandes nimmt teil an der wechselvollen Geschichte der jüdischen Menschen und ihrer Gemeinde.
Der erste Jude, der sich im 17. Jahrhundert in Schwedt niederließ, war Bendix Levi. Nachdem sein Haus in Oderberg abgebrannt war, erhielt er von Kurfürst Friedrich Wilhelm die Genehmigung zum Aufenthalt in Schwedt. Die preußischen Könige wünschten jedoch, daß in den kleinen brandenburgischen Städten nur wenige Juden leben sollten. Deshalb bestand während des 18. Jahrhunderts die jüdische Gemeinschaft in Schwedt nur aus Angehörigen von drei Familien, nämlich von Bendix Levi, Simon Salomon und Wulff Salomon. Ihr Leben war geprägt vom Kampf um Aufenthaltsrecht und Handelserlaubnis. Solidarität untereinander war dabei nicht immer selbstverständlich, da oft das Aufenthaltsrecht des einen, wirklich oder vermeintlich, dem Recht des anderen entgegenstand.
Das umfangreiche Quellenmaterial aus Berliner, brandenburgischen und Jerusalemer Archiven führt uns die Auswirkungen der restriktiven preußischen Judenpolitik auf das Leben der Schwedter Juden lebendig vor Augen und gibt uns außerdem Einblicke in jüdische Traditionen und Gebräuche. So werden wir Zeugen einer jüdischen Eidesleistung im Schwedter Rathaus und nehmen teil an der feierlichen Unterzeichnung eines Heiratsvertrages.
Das Emanzipationsedikt von 1812 machte Juden endlich zu preußischen Staatsbürgern und erleichterte das Leben durch Niederlassungs- und Gewerbefreiheit. Dies führte bald zu einer beträchtlichen Vergrößerung der Schwedter jüdischen Gemeinde, der sich auch die jüdischen Einwohner des nahe gelegenen Städtchens Vierraden anschlossen. Als erster ließ sich Israel David Loewenheim aus Tütz / Westpreußen in Schwedt nieder. Ihm folgten aus seiner Heimatstadt nicht weniger als sieben weitere Familien. Zuzüge gab es auch aus anderen Städten, sodass bis zum späten 19. Jahrhundert die Zahl der jüdischen Einwohner Schwedts bis auf ca. 200 Personen zunahm. Ab ca. 1880 führten dann jedoch zahlreiche Wegzüge – besonders nach Berlin – wieder zu einer Verkleinerung der Gemeinde.
Seit 1840 war Schwedt Amtssitz eines Rabbiners. Nathan Hirsch Kuttner blieb bis zu seiner Pensionierung im Jahr 1895 in Schwedt. Dieses lange Zusammenleben lässt ein harmonisches Verhältnis zwischen ihm und der Gemeinde vermuten. Dies war aber in den ersten Jahren durchaus nicht der Fall. Kuttner musste einige Jahre um Anerkennung in der Gemeinde kämpfen und sogar die Zahlung seines Gehalts gerichtlich durchsetzen. Der Bau einer neuen Synagoge im Jahr 1862 gab der Gemeinde neues Zusammengehörigkeitsgefühl und brachte Ruhe in die Auseinandersetzungen mit dem Rabbiner.
Unter dem Eindruck des zunehmenden Antisemitismus im ausgehenden 19. und im 20. Jahrhundert schloss sich die Gemeinde Vereinen und Organisationen an, die sich den antisemitischen Angriffen entgegenzustellen versuchten, so 1894 dem „Deutsch-Israelitischen Gemeindebund“ und 1901 dem „Verein zur Abwehr des Antisemitismus“. Im Jahr 1922 gründete man die „Reuchlin Loge“ im Verband „Unabhängiger Orden Bne-Beriss“.
Bald folgte das schnelle und vollständige Ende der jüdischen Gemeinde in Schwedt durch den nationalsozialistischen Massenmord. In der Datenbank der Gedenkstätte Yad Vashem in Jerusalem wird die Erinnerung an 60 namentlich bekannte ermordete Schwedter Juden aufbewahrt. Nachfahren von Überlebenden hat es in alle Erdteile verschlagen.
Intensive genealogische Forschungen in Zusammenarbeit mit Peter Lowe aus Hertford (UK), einem Nachkommen der Familie Loewenheim, und Yehuda Meinhardt (Israel) machten es möglich eine Reihe von Familienstammbäumen zu rekonstruieren.
Der Band wird mit der Beschreibung des jüdischen Friedhofs und der Erfassung der Grabinschriften abgeschlossen. Eine ausführliche Dokumentation mit Fotografien findet sich im Internet (www.uni-potsdam.de/juedische-friedhoefe).<br>For 270 years there was Jewish life in the Brandenburg town of Schwedt on the Oder. The reader of this volume participates in the changing history of the Jewish people and their community.
The first Jew to settle in Schwedt in the 17th century was Bendix Levi. After his house in Oderberg burned down, Kurfürst Friedrich Wilhelm granted him permission to take up residence in Schwedt. The Prussian Kings wanted only few Jews to live in small Brandenburg towns, so during the 18th century the Jewish community in Schwedt consisted of only three families whose heads were Bendix Levi, Simon Salomon and Wulff Salomon. Their life was dominated by the fight for residency and trade permits. Solidarity amongst each other was not always self evident, since the residency permit of one was often in real or imagined conflict with a permit for others.
The extensive sources in archives in Berlin, Brandenburg and Jerusalem show intensely the consequences of the restrictive Prussian “Judenpolitik” on the life of Jews in Schwedt and they also give us insight into Jewish traditions and customs. We bear witness to a Jewish oath in the townhouse of Schwedt and take part in the ceremonial signing of a marriage treaty. The “Emanzipationsedikt” of 1812 finally made Jews into Prussian citizens and simplified their life by giving them freedom of settlement and trade. This resulted in considerable growth of the Jewish community in Schwedt which was also joined by the Jewish residents of the nearby town of Vierraden. The first of these new settlers in Schwedt was David Loewenheim from Tütz / Westprussia. No less than seven families from his hometown followed. There was also immigration from other towns, increasing the number of Jewish residents in Schwedt to 200 by the late 19th century. After about 1880 the community shrank again because many moved away, particularly to Berlin.
Since 1840 Schwedt was the seat of a Rabbi. Nathan Hirsch Kuttner stayed in Schwedt until his retirement in 1895. Although this long sojourn might indicate an agreeable relationship between him and his community, this was certainly not the case in his first years. Kuttner had to fight for recognition by his community and even had to obtain a court order to collect his salary. The building of a new Synagogue in 1862 gave a new sense of cooperation to the community and calmed the struggles with the Rabbi.
Under the impression of increasing anti-Semitism from the late 19th into the 20th century, the community joined organizations which attempted to resist anti-Semitic attacks. For example, in 1894 it joined the “Deutsch- Israelitische Gemeindebund” and in 1901 the “Verein zur Abwehr des Antisemitismus”. In 1922 the “Reuchlin Loge”, was formed within the “Independent Order of Bnai Brith”.
Soon followed the fast and complete anihilation of the Jewish community in Schwedt by the national socialist mass murder. The Central Database of Shoah Victims' Names at Yad Vashem / Jerusalem preserves the memory of 71 murdered Jews of Schwedt who are known by name. Descendants of survivors are scattered to all parts of the world.
Intensive genealogical research in cooperation with Peter Lowe from Hertford (UK), descendant of the Loewenheim family, and Yehuda Meinhardt (Israel), made it possible to reconstruct a number of family trees.
The volume ends with a description of the Jewish cemetery and a record of the grave inscriptions. An entire documentation with photographs can be found in the Internet (www.uni-potsdam.de/juedische-friedhoefe).
34
Tritten, Katharina Barbara. "Gesundheitsfachfrauen in Ausbildung : ihr Rauchverhalten, ihr Wissen über die Tabakprävention und ihre berufsbedingten Einstellungen dazu /." Niederscherli : [s.n.], 2006. http://www.public-health-edu.ch/new/Abstracts/TK_05.04.07.pdf.
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Senft, Matthias. "Prozesskettenintegriertes sicheres Lochen von IHU-Bauteilen." Berlin Logos-Verl, 2009. http://d-nb.info/999661388/04.
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Dietrich, Thie. "Versteht Ihr Handy IP? - Drahtlose Internetanbindung." Universitätsbibliothek Chemnitz, 1998. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-199800369.
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Schönbach, Renate. "Veränderungen im IgG–Subklassenprofil bei Tumorerkrankungen." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-107830.
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(UPC), Universidad Peruana de Ciencias Aplicadas. "IHC y Tecnologias Moviles - SI385 201801." Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/623266.
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Curso de especialidad en las carreras de Ingeniería de Software y Ingeniería de Sistemas de Información de
carácter teórico-práctico dirigido a los estudiantes del 4to ciclo, que busca desarrollar la competencia de
UTILIZAR TÉCNICAS, HERRAMIENTAS Y METODOLOGÍAS NECESARIAS PARA LA PRÁCTICA DE
LA INGENIERÍA, acorde con el outcome (K)de ABET.
El curso servirá a los alumnos a comprender cómo hacer la transición de lo que ¿se debe hacer¿ (funcionalidad)
hacia ¿cómo debe hacerse¿ para cubrir los requerimientos del usuario (usabilidad) en el contexto específico de
trabajo. Para lograrlo el estudiante seleccionará las interfaces adecuadas (físicas y virtuales) procurando los
mejores esquemas de interacción (formas, lenguaje natural, GUI¿s, etc.).
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Tramp, Martin. "Tachodreh - und niemand kann ihn erkennen." Saarbrücken VDM, Müller, 2004. http://deposit.d-nb.de/cgi-bin/dokserv?id=2872407&prov=M&dok_var=1&dok_ext=htm.
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Kolb, Annika. "Portfolioarbeit : wie Grundschulkinder ihr Sprachenlernen reflektieren /." Tübingen : Narr, 2007. http://deposit.d-nb.de/cgi-bin/dokserv?id=2875517&prov=M&dok_var=1&dok_ext=htm.
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Baruah, Kavitha. "Structural biology of IgG Fc glycoforms." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:def683d3-aa06-41d9-9f28-29d21258bebe.
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The conserved N-linked glycosylation site on the Fc domain of IgG1 antibodies is essential for maintaining a functionally active conformation of the antibody. Different glycoforms of the Fc exhibit widely different effector functions. Similarly, therapeutic antibodies, with engineered glycosylation, exhibit altered binding to cellular Fc receptors (FcRs). Here, X-ray crystallographic structures were obtained for biosynthetic intermediate glycoforms of human IgG1 Fc bearing: unprocessed oligomannose-type, intermediate hybrid-type, and mature complex-type glycans. The fully processed Fc protein crystallised in an “open” conformation with glycans forming canonical stabilising interactions on the protein surface. Analysis of the biosynthetic intermediates revealed that these stabilising hydrophobic protein-glycan interactions are formed only after processing by Golgi -mannosidase II. Mutagenesis of hydrophobic residues on Fc disrupted crucial protein-glycan interactions resulting in the selective destabilization of the 3-arm of the glycan chain with the 6-arm closely matching that seen for the native structure. However, carbohydrate analysis of released glycans shows increased processing on both arms indicating a more accessible and flexible glycan in the mutant structure suggesting that the crystallographic structure of these antibody glycans represents a minor low-energy conformation. The importance of Fc glycosylation is highlighted by endoglycosidases which eliminate Fc effector function. The crystallographic structure of enzymatically deglycosylated IgG Fc revealed a significant collapse of the of Cγ2 domains resulting in a ‘closed’ quaternary conformation, incompatible with Fc receptor binding. This provides a structural explanation for immune deactivating properties of endoglycosidases including those under preclinical development for the treatment of antibody-mediated immune pathology. One such bacterial endoglycosidase, Endo S, was studied further and revealed a specificity for complex-type glycans of the type found on IgG but no hydrolytic activity towards an engineered IgG Fc with oligomannose-type glycans. Introduction of both the engineered monoclonal IgG and endoglycosidase in serum led to a dramatic increase in FcR binding as the competitive binding of serum IgG for FcRs was selectively eliminated. This approach is a general technique for boosting the effector signal of therapeutic antibodies.
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Editorial, Comité. "Entrevista al Ing. Saúl Montoya Heredia." Civilizate, 2015. http://repositorio.pucp.edu.pe/index/handle/123456789/114661.
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Kohlheim, Volker. "Die literarische Figur und ihr Name." Gesellschaft für Namenkunde e.V, 2007. https://ul.qucosa.de/id/qucosa%3A31518.
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In order to explain the role of proper names in narrative fiction the literary text is seen as a system which, however, is connected to the “real world' in many ways. As a work of art the literary text is characterized by the predominance of the aesthetic function. From applying R. JAKOBSON’S and J. MURAKOVSKY’S concept of the aesthetic sphere as the sphere where the linguistic sign primarily reveals its inherent aesthetic and semantic values follows that the communicative functions of the proper name in literary texts are reverse to their order in everyday communication: It is not the identifying function of the proper name which is dominant in literary texts, but rather all the other semantic and phonic values which in real-world communication usually are not realized.
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Гребенюк, В. О. "Академія IMG - школа вищої спортивної майстерності". Thesis, КНТУ, 2011. http://dspace.kntu.kr.ua/jspui/handle/123456789/6115.
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Arnold, Klaus. "Qualitätsjournalismus die Zeitung und ihr Publikum." Konstanz UVK Verl.-Ges, 2008. http://d-nb.info/992160014/04.
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Tanner, Debora. "Die minderjährige Mutter und ihr Kind." München AVM, 2009. http://d-nb.info/99639155X/04.
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PIRES, E. C. "Oswald (ing): Antropofagia, culturas e fronteiras." Universidade Federal do Espírito Santo, 2012. http://repositorio.ufes.br/handle/10/3266.
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Previous issue date: 2012-06-27<br>A partir de uma abordagem que relaciona os estudos pós-coloniais e as teorias da tradução, este trabalho indaga o uso dos empréstimos linguísticos e estrangeirismos na poética de Oswald de Andrade como atos de tradução e crítica anti/pós-colonial. Categorias pós-coloniais oriundas das pesquisas de Edward Said, Homi Bhabha e Gayatri Spivak como a ruptura das fronteiras, a diferença como categoria enunciativa e a temporalidade do entre-lugar e questões como as metáforas da tradução e a intraduzibilidade em diálogo com a ampla fortuna crítica produzida sobre Oswald de Andrade no país fomentam uma análise minuciosa do gesto antropofágico nos textos literários O Manifesto Antropófago (2011) e Memórias Sentimentais de João Miramar (2004), que servem como corpus para análise. O resultado do trabalho aponta para a necessidade de inventariarmos em nossos debates pós-coloniais atuais uma razão antropofágica que lhe antecede e que permite revelar aspectos importantes do pós-colonialismo no Brasil.
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Pires, Eloá Carvalho. "Oswald(ing): antropofagia, culturas e fronteiras." Universidade Federal do Espírito Santo, 2012. http://repositorio.ufes.br/handle/10/6426.
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Previous issue date: 2012-06-27<br>By considering an approach which relates postcolonial studies and translation theories, this study questions the use of linguistic loans and foreignisms in Oswald de Andrade s poetic productions as translation acts and anti/postcolonial critique. The postcolonial categories presented by researchers as Edward Said, Homi Bhabha and Gayatri Spivak namely, the rupture of frontiers, difference as an enunciative category and temporality in the in-between space and questions on translation metaphors and untranslatability, in dialogue with the rich critique produced on Oswald de Andrade, stimulate the careful analysis of anthropophagy in the literary texts taken as our corpus: O Manifesto Antropófago (2011) and Memórias Sentimentais de João Miramar (2004). The result of the present research stresses the need for considering, within our current postcolonial debates, the anticipation of this anthropophagic reasoning, thus revealing a better understanding of important postcolonial aspects in Brazil<br>A partir de uma abordagem que relaciona os estudos pós-coloniais e as teorias da tradução, este trabalho indaga o uso dos empréstimos linguísticos e estrangeirismos na poética de Oswald de Andrade como atos de tradução e crítica anti/pós-colonial. Categorias pós-coloniais oriundas das pesquisas de Edward Said, Homi Bhabha e Gayatri Spivak como a ruptura das fronteiras, a diferença como categoria enunciativa e a temporalidade do entre-lugar e questões como as metáforas da tradução e a intraduzibilidade em diálogo com a ampla fortuna crítica produzida sobre Oswald de Andrade no país fomentam uma análise minuciosa do gesto antropofágico nos textos literários O Manifesto Antropófago (2011) e Memórias Sentimentais de João Miramar (2004), que servem como corpus para análise. O resultado do trabalho aponta para a necessidade de inventariarmos em nossos debates pós-coloniais atuais uma razão antropofágica que lhe antecede e que permite revelar aspectos importantes do pós-colonialismo no Brasil
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Rodrigues, Junior Valnês da Silva. "Avaliação pré-clínica dos compostos IQG-607 e IQG-639 em um modelo de tuberculose em camundongos." Pontifícia Universidade Católica do Rio Grande do Sul, 2012. http://hdl.handle.net/10923/4487.
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Previous issue date: 2012<br>Tuberculosis continues to be one of the deadliest diseases in the world. The emergence of drug-resistant strains of Mycobacterium tuberculosis, the unbearable side effects of the available drugs and the frequent patient non-compliance in completing the therapy have increased the need for development of new effective agents. We have previously demonstrated a potent in vitro inhibitory activity for two pentacyano(isoniazid)ferrate(II) compounds, namely IQG-607 and IQG-639 against the M. tuberculosis enoyl-ACP reductase enzyme. Importantly, IQG- 607 and IQG-639 were active against cultures of M. tuberculosis H37Rv and two isoniazid-resistant clinical isolates in vitro. In the present study, the activity of these compounds was evaluated by using an in vivo murine model of tuberculosis. Swiss mice were infected with M. tuberculosis H37Rv strain, and IQG-607 and IQG-639 (250 mg/kg) were administered during 28 or 56 days. As well, a dose-response study was performed with IQG-607 (at 5, 10, 25, 50, 100, 200 and 250 mg/kg). The activity of test compounds was compared with that of the positive control drug isoniazid at 25 mg/kg. After 28 or 56 days of treatment, either IQG-607 or isoniazid significantly reduced M. tuberculosis-induced splenomegaly, and also significantly diminished the colony-forming units in both spleens and lungs. IQG-607 or isoniazid ameliorated the lung macroscopic aspect, reducing the lung lesions to a similar extent. However, IQG-639 was not capable of significantly modifying any evaluated parameter. IQG-607 did not display a classical dose-dependent profile in our murine model of tuberculosis, and 10 mg/kg was the lowest dose able to show significant activity, which was similar to the inhibition observed for higher doses. In addition, experiments using early and late controls of infection revealed a bactericidal activity for IQG-607 in our model. The promising activity of IQG-607 in M. tuberculosis-infected mice suggests that this compound might represent a good candidate for clinical development as a new antimycobacterial agent.<br>A tuberculose é uma das principais causas de morte no mundo. O surgimento e disseminação de cepas de Mycobacterium tuberculosis resistentes a fármacos, os efeitos indesejáveis dos fármacos atualmente disponíveis e a falta de adesão dos pacientes ao tratamento têm aumentado a necessidade do desenvolvimento de novos agentes anti-tuberculose. Estudos prévios revelaram uma potente atividade inibitória in vitro de dois compostos pentaciano(isoniazida)ferrato(II), denominados IQG-607 e IQG- 639, frente a enzima enoil-ACP redutase de M. tuberculosis. Ainda, o IQG- 607 e o IQG-639 foram ativos quando testados em culturas de M. tuberculosis H37Rv e sobre dois isolados clínicos resistentes à isoniazida in vitro. Neste trabalho, a atividade destes dois compostos foi avaliada in vivo, utilizando um modelo murino de infecção por M. tuberculosis. Camundongos suíços foram infectados com a cepa de M. tuberculosis H37Rv e o IQG-607 ou o IQG-639 (250 mg/kg) foram administrados aos animais durante 28 ou 56 dias. Adicionalmente, um estudo de dose-resposta foi realizado com o composto IQG-607, empregando as doses de 5, 10, 25, 50, 100, 200 e 250 mg/kg. As atividades dos compostos-teste foram comparadas à atividade da isoniazida (25 mg/kg), o controle positivo do tratamento. Após 28 ou 56 dias de tratamento, tanto o IQG-607 quanto a isoniazida reduziram significativamente a esplenomegalia induzida pela infecção e, também, diminuíram as unidades formadoras de colônia, tanto nos pulmões quanto nos baços dos animais tratados. O IQG-607 e a isoniazida melhoraram o aspecto macroscópico dos pulmões, reduzindo as lesões pulmonares de maneira semelhante. Por sua vez, o IQG-639 não foi capaz de modificar significativamente nenhum parâmetro avaliado neste estudo. O IQG-607 não apresentou um perfil clássico de dose dependência, sendo observada atividade inibitória significativa similar, entre as doses de 10 mg/kg e 250 mg/kg. Além disto, um experimento utilizando um “controle pré-tratamento” demonstrou que o IQG-607 possui atividade bactericida no nosso modelo. A atividade satisfatória do IQG-607 em camundongos infectados com M. tuberculosis sugere que este composto pode ser um candidato promissor no desenvolvimento clínico de um novo agente antimicobacteriano.
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Cerný, Jirí [Verfasser]. "Die Flugschriften der Frühreformation aus Nord- und Nordwestböhmen : Ihr Wesen und ihr Bezug zu Wittenberg / Jirí Cerný." Frankfurt a.M. : Peter Lang GmbH, Internationaler Verlag der Wissenschaften, 2021. http://d-nb.info/1236117166/34.
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