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Dissertations / Theses on the topic 'IL-4'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Dawson, Charlotte Helen. "STAT 6 and IL-4 signalling." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245716.

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2

Nieuwenhuizen, Natalie. "Immune and allergic responses to Anisakis pegreffii, with focus on the roles of IL-4, IL-13 and the IL-4 receptor alpha." Doctoral thesis, University of Cape Town, 2007. http://hdl.handle.net/11427/3115.

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Includes bibliographical references (p. 117-127).<br>The fish-parasitizing nematode Anisakis pegreffii induces gastrointestinal disease and allergy when ingested by humans, and can cause occupational allergy in seafood processing workers. The present study examines immune and allergic responses to A. pegreffii in wildtype and gene deficient mice, with special focus on interleukin(IL)-4, IL-13, and the IL-4 receptor alpha (IL-4Rα). Experimental murine models of Anisakis infection, Anisakis-induced anaphylaxis and Anisakis-induced dermatitis were established in order to gain insight into the imm

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3

Oksuz, Samet. "Targeting IL-4 locus for epigenetic reprogramming." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1423581203.

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4

Govender, Melissa. "Investigating the role of IL-4/IL-13 signalling through the IL-4 receptor alpha (IL-4Rα) on keratinocytes in murine models of Leishmania major and Schistosoma mansoni". Doctoral thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/24890.

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Keratinocytes represent the major cell type in the skin. During cutaneous leishmaniasis (CL) and schistosomiasis, the skin is important during the parasite life cycle. While Th1 immunity is required to control CL, protection during schistosomiasis requires Th2 immunity. Paradoxically, Th2 characteristic IL-4 secreted early during L. major infection in mice, can drive a Th1 response by instructing dendritic cells to produce IL-12. Additionally, keratinocytes at the site of L. major infection in C57BL/6 mice, were postulated to be the source of the IL-4. We investigated if IL-4/IL-13 signalling

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5

Мозгова, Юлія Анатоліївна, Юлия Анатольевна Мозговая та Yuliia Anatoliivna Mozghova. "Динаміка вмісту IL-4 та IL-6 при хронічному тонзиліті в дітей". Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32359.

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Хронічне запалення піднебінних мигдаликів є розповсюдженим захворюванням дитячого віку, що несприятливо впливає на зростаючий організм. На хронічний тонзиліт страждає більше 2-3% дітей раннього віку, 6-7% - дошкільного та 8-9% школярів. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/32359

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6

Pizzuti, Lucas. "Síntese de 4-(fur-2-il)- e 4-(tien-2-il)-pirimidinas a partir de β-Alcoxivinil trifluormetil cetonas". Universidade Federal de Santa Maria, 2005. http://repositorio.ufsm.br/handle/1/10401.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The cyclocondensation of the 1,1,1-trifluoro-4-methoxy-4-(2-heteroaryl)-3-buten-2-ones (heteroaryl = furyl and thienyl) with urea and amidines (acetamidine, benzamidine, guanidine, 1H-pyrazole-1-carboxamidine and 2-methyl-2-thiopseudourea) for synthesis of two 4-(2-heteroaryl)-6-trifluoromethylpyrimidinones and a series of ten 4-(2-heteroaryl)-6-trifluoromethylpyrimidines is reported. The reaction of the 1,1,1-trifluoro-4-methoxy-4-(2-heteroaryl)-3-buten-2-ones with urea was carried out in the presence of boron trifluoride ethera

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7

Cirocco, Robert E. "Cytokine analisys in atlantic bottlenose dolphins: molecular characterization of IL-4, IL-6, and IL-10." FIU Digital Commons, 2001. http://digitalcommons.fiu.edu/etd/2370.

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The health status of wild and captive Atlantic Bottlenose dolphins (Tersiops truncatis) is difficult to ascertain. Mass strandings of these animals have been attributed to pollutants, as well as bacterial infections. Using human Enzyme Linked Immuno-Assays (ELISA) for immunological cytokines, I measured soluble cytokine levels with respect to their health status. In a retrospective analysis of dolphin sera, there was a trend of higher cytokine levels in “sick” animals. I cultured dolphin lymphocytes in the presence of a mitogen (PHA), a super antigen (Staph-A), Lipopolysaccharide (LPS), and a

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8

Vale, Mariana Lima. "Atividade analgesica das interleucinas 4, 10 e 13 (IL-4, IL-10 e il-13) na dor inflamatoria experimental : papel de celulas residentes e citocinas." reponame:Repositório Institucional da UFC, 2000. http://www.repositorio.ufc.br/handle/riufc/2569.

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VALE, Mariana Lima. Atividade analgesica das interleucinas 4, 10 e 13 (IL-4, IL-10 e il-13) na dor inflamatoria experimental : papel de celulas residentes e citocinas. 2000. 140 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal do Ceará. Faculdade de Medicina, 2000.<br>Submitted by denise santos (denise.santos@ufc.br) on 2012-05-04T12:19:28Z No. of bitstreams: 1 2000_dis_mlvale.pdf: 664941 bytes, checksum: a8df00b6a53f2d6632ebe816657800aa (MD5)<br>Approved for entry into archive by Eliene Nascimento(elienegvn@hotmail.com) on 2012-05-04T12:36:24Z (GMT) No. of bitstreams: 1 2000_

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9

Toor, Iqbal Singh. "Investigating the role of eosinophils in cardiac remodelling following myocardial infarction." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31187.

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Myocardial infarction (MI) occurs following acute thrombotic occlusion of a coronary artery, and triggers a robust inflammatory response. Within hours, neutrophils are recruited to the infarcted myocardium followed by the infiltration of pro-inflammatory Ly6Chi monocytes. Transition from the pro-inflammatory macrophage phenotype (M1) to an anti-inflammatory, pro-resolution phenotype (M2-like) is critical to successful infarct healing. Interventions that polarize macrophages towards an anti-inflammatory 'M2-like' phenotype improve infarct healing in the experimental MI mouse model and reduce su

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10

Dheda, Keertan Unkha Jairam. "The expression and role of IL-4 and IL-4(delta)2 in tuberculosis with and without HIV co-infection." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445411/.

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Background: Tuberculosis progresses despite potent Thl responses. A putative explanation is the presence of a subversive Th2 response. However interpretation is confounded by a novel cytokine, IL-452, a splice variant and inhibitor of IL-4. Methods: The expression of Thl cytokines (IFN-y), IL-452, Th2 cytokines (IL-4) and sCD30 was investigated in whole blood, lung lavage and mononuclear cell cultures from donors with TB, TB-HIV co-infection, and matched controls. Results: After validation of a fluorogenic real-time RT-PCR assay, the half-life of IL- 4 mRNA, but not IL-452, was found to be pro

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11

Green, Lisa J. "The production of IL-2, IL-4, and TNF-gas in murine leishmaniasis." Virtual Press, 1991. http://liblink.bsu.edu/uhtbin/catkey/774758.

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Prophylactic administration of the immunosuppressive drug cyclosporine A protects Balb/c mice from fatal Leishmania major infections. It is believed that distinct subpopulations of CD4+ T lymphocytes and their distinctive cytokines may determine susceptibility and resistance to leishmaniasis among inbred strains of mice. CsA may enhance disease resistance in Balb/c mice by modulating these T cell subsets and/or their cytokines. We have measured lymphoid cell production of IL-2, IL-4, and TNF-a in naturally resistant C57/Bl/6, CsA-treated Balb/c, and nontreated Balb/c mice during the course of

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12

Rogan, David Frances. "Studies on the regulation of the Human IL-4/IL-13 gene cluster." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289815.

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13

Worm, Margitta. "Mechanismen der CD40/IL-4-abhängigen IgE-Regulation." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2000. http://dx.doi.org/10.18452/13716.

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IgE ist das Schlüsselmolekül Typ-I allergischer Erkrankungen.. Die Produktion von IgE wird durch die Interaktion des Oberflächenmoleküls CD40 auf B-Zellen mit seinem Liganden (CD40L), dass von aktivierten T-Zellen exprimiert wird, sowie über Signale durch die Zytokine IL-4 oder IL-13 von B-Zellen produziert. Die CD40/IL-4-abhängige IgE-Produktion in vitro kann einerseits als Modell zum Verständnis der Entstehung allergischer Erkrankungen eingesetzt werden; andererseits können potenziell therapeutisch wirksame Substanzen untersucht werden. Untersuchungen zum Verständnis allergischer E

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14

Viezzer, Nicole <1993&gt. "Il nuovo articolo 4 dello Statuto dei lavoratori." Master's Degree Thesis, Università Ca' Foscari Venezia, 2018. http://hdl.handle.net/10579/12585.

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L'elaborato presenta un discorso generale sui poteri di controllo del datore di lavoro con analisi del concetto di subordinazione e relative pronunce giurisprudenziali in materia. Prosegue presentando la disciplina previgente dell'articolo 4 con esposizione delle tematiche principali quali nozioni di strumenti di controllo ed altre apparecchiature, necessità di accordo sindacale e analisi della travagliata disciplina dei controlli difensivi. Inoltre, come parte finale al capitolo 2, vengono analizzati aspetti reali quali accessi a posta elettronica, internet, telefonate e gps. Infine nel terzo

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15

Matthews, David John. "A study of human B cell responses induced by IL-4 and IL-13." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265340.

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16

Hibbert, Linda Margaret. "Structure and function of IL-4 and IL-13 receptors on human B cells." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244615.

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17

Campbell, Harding Gemma. "Regulation of IL-4 mediated signalling in primary human bronchial fibroblasts by IL-13Rα2". Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/372927/.

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Fibroblasts are key effector cells involved in airway inammation and remodelling in asthma. Interleukin (IL)-4 and IL-13 are important cytokines in the asthma phenotype which act on fibroblasts and other cell types. These cytokines exhibit overlapping functions through use of a common receptor, IL-4Rα:IL-13Rα1. Another receptor, IL 13 Receptor α2 (IL-13Rα2), originally thought to be a decoy receptor for IL-13, has recently been shown to attenuate responses to IL-4 as well as IL-13, by an unknown mechanism. In this thesis, I tested the hypothesis that IL-13Rα2 is responsible for the regulation

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18

Marillier, Reece Gerrad. "The role of IL-4 and IL-13 responsiveness during Schistosoma mansoni induced inflammation." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/3113.

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Includes abstract.<br>Includes bibliographical references (leaves 117-129).<br>Schistosoma mansoni egg passage through intestinal tissue into the faecal stream is a critical event for completion of the life cycle of the helminth and involves induction of a type 2 immune response, which is necessary for the host’s survival. Where as T cell-specific IL-4Rα has been shown not to be essential for survival, macrophage/neutrophil-specific IL-4 receptor α-deficient mice (LysMIcre L-4Rα-/lox ), mice lacking alternative macrophages (AAMФ), had severe intestine pathology and high endotoxin levels due to

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19

Hoving, J. Claire. "Investigating the role of IL-4/IL-13 and their receptors in ulcerative colitis." Doctoral thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/3164.

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Ulcerative colitis (UC) is a heterogeneous inflammatory bowel disease (IBD) associated with chronic inflammation of the gastrointestinal tract. Characterized by genetic and immunological abnormalities, UC has overly aggressive T-cell responses to commensal bacteria eventually leading to disease pathology. UC is distinguished from Crohn's disease, another form of IBD, in that it is driven by a T helper type 2 (Th2) immune response. Oxazolone-induced colitis is a mouse model resembling UC presenting with inflammation limited to the distal colon and mixed neutrophil/lymphocyte infiltration in the

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20

Conde, García Eva. "Anti -IL-4, -IL-13 and -IgE vaccination for the treatment of allergic diseases." Thesis, Sorbonne université, 2020. https://accesdistant.sorbonne-universite.fr/login?url=http://theses-intra.upmc.fr/modules/resources/download/theses/2020SORUS011.pdf.

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Les allergies représentent un problème de santé majeur avec une prévalence en nette augmentation et pour lesquelles il n’existe pas de thérapie à longue durée. L’IL-4, l’IL-13 et l'IgE jouent un rôle clé dans les réactions allergiques. Ces cibles thérapeutiques ont été validées en clinique, grâce aux anticorps monoclonaux. Néanmoins, leur utilisation reste contraignante de par leur coût excessif et la nécessité de réinjections fréquentes. L’objectif de cette thèse a été de développer des vaccins contre l’IL-4, l’IL-13 et l’IgE, appelés kinoïdes, et d’apporter la preuve de concept de l’efficaci

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21

Vilela, Josie Fadul 1982. "Investigação dos polimorfismos dos genes da interleucina-1 (IL-1), IL1RN, IL-4, IL-6 e IL-10 em pacientes adultos portadores de púrpura trombocitopênica imune = Investigation of interleukin-1 (IL-1), IL1RN, IL-4, IL-6 and IL-10 gene polymorphism adult patients with immune thrombocytopenic purpura." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310653.

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Orientador: Marcelo Addas Carvalho<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T03:08:54Z (GMT). No. of bitstreams: 1 Vilela_JosieFadul_M.pdf: 1739915 bytes, checksum: ea1d6c47907a49ccd0e00255b01d3dee (MD5) Previous issue date: 2012<br>Resumo: A Púrpura Trombocitopênica Imune (PTI) é uma doença autoimune caracterizada pela presença de autoanticorpos contra as glicoproteínas de membrana plaquetária, tais como GPIIb/IIIa e GPIb/IX. O processo patogênico da PTI envolve uma destruição acelerada das plaqueta

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22

Nogara, Pablo Andrei. "Síntese de (5-trifluormetil-1H-pirazol-1-IL)(quinolin-4-IL)metanonas de interesse farmacológico." Universidade Federal de Santa Maria, 2016. http://repositorio.ufsm.br/handle/1/10627.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>A convergent synthesis of a series of 16 new polysubstituted (5-hydroxy-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)(quinolin-4-yl)methanones, starting from isatin and alky(aryl/heteroaryl) ketones, is described. The diheteroaryl methanones were achieved at yields of up to 95% by a (3 + 2) cyclocondensation reaction involving 4-alkyl(aryl/heteroaryl)-4-methoxy-1,1,1-trifluorobut-3-en-2-ones (by two-step reaction) and 2-alkyl(aryl/heteroaryl)-4-carbohydrazides (by three-step reaction). Subsequently, representative dehydrated het

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23

Піддубна, Анна Іванівна, Анна Ивановна Поддубная, Anna Ivanivna Piddubna, Микола Дмитрович Чемич, Николай Дмитриевич Чемич та Mykola Dmytrovych Chemych. "Прогностичне значення алельного поліморфізму генів IL-4, IL-10, TNF-α у ВІЛ-інфікованих осіб". Thesis, Укрмедкнига, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32436.

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З’ясовано взаємозв’язок розподілу алельних варіантів генів IL-4, IL-10, TNF-α у ВІЛ-інфікованих пацієнтів з різними типами перебігу інфекційного процесу. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/32436<br>Установлена взаимосвязь распределения аллельных вариантов генов IL-4, IL-10, TNF-α у ВИЧ-инфицированных пациентов с различными типами течения инфекционного процесса. При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/32436<br>It was found the correlation distribution of allelic variants of IL-4, IL-10

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24

Specht, Sabine. "Antagonism between IL-4 and IL-10 in colitis and a helminth infection in Mus musculus." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975502085.

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25

Maas, Sibylle. "Die Rolle von IL-13 und IL-4 bei der Entstehung des Asthma bronchiale im Kindesalter." [S.l. : s.n.], 2007.

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26

Verma, Akash. "Unraveling the IL4-IL33 Nexus in Histoplasma Capsulatum Infection." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1406898828.

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27

Michel, Marie-Laure. "Etude d’une nouvelle sous-population de lymphocytes iNKT productrice d’IL-17." Paris 6, 2008. http://www.theses.fr/2008PA066077.

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Les cellules iNKT (invariant Natural Killer T) constituent une population distincte de lymphocytes T matures, dont le TCR semi-invariant reflète une sélection positive par la molécule CD1d. Les cellules iNKT activées produisent rapidement et massivement des cytokines pro-Th1 (IFN-γ) et pro-Th2 (IL-4) et influencent de nombreuses maladies. Récemment, nous avons identifié une nouvelle sous-population de cellules iNKT, de phénotype NK1. 1neg, productrice d’IL-17 (iNKT17) qui sécrète peu d’IL-4 et d’IFN-γ. Ces cellules exercent notamment un rôle dans les réponses inflammatoires pulmonaires (Michel

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28

Walter, Johanna-Julia. "Der Einfluss von IL-10 auf die allergeninduzierte IL-4- und IL-13-Freisetzung aus basophilen Granulozyten von Patienten mit Wespengiftallergie." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-109346.

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29

Guiter, Chrystelle. "Étude de la voie de signalisation IL-4/IL-13 dans les lymphomes B primitifs du médiastin." Thesis, Paris Est, 2008. http://www.theses.fr/2008PEST0053.

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Les lymphomes B primitifs du médiastin (LBPMs) constituent une entité anatomo-clinique particulière au sein des lymphomes diffus à grandes cellules B. Les analyses du transcriptome des LBPMs ont montré une forte expression des gènes induits par l’IL-4 ou l’IL-13 et des effecteurs de cette voie de signalisation. L’objectif de ce travail a été d’étudier la voie IL-4/IL-13 dans les LBPMs. Dans une 1ere partie, nous avons montré que le facteur de signalisation et de transcription 6 (STAT6) est constitutivement phosphorylé et possède une activité de liaison à l’ADN dans les lignées dérivées de LBPM

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Santangelo, Samantha. "Studies on the chromatin structure of the IL-4/IL-13 gene cluster in human T lymphocytes." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289840.

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Сміян, Олександр Іванович, Александр Иванович Смиян, Oleksandr Ivanovych Smiian, Вікторія Віталіївна Слива, Виктория Витальевна Слива та Viktoriia Vitaliivna Slyva. "Стан опозиційних пулів цитокінів IL-1 та IL-4 при гострих обструктивних бронхітах у дітей раннього віку". Thesis, Вид-во СумДУ, 2011. http://essuir.sumdu.edu.ua/handle/123456789/15743.

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Нікітіна, О. Є., Н. М. Настрадіна, Н. В. Муріна та І. М. Стасій. "Стан продукції інтерферону-γ та інтерлейкінів IL-4 І IL-10 у хворих папіломавірусною інфекцією шийки матки". Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32270.

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Імунна відповідь організму на вірус папіломи людини (ВПЛ) включає цілий ряд факторів захисту організму від патогенної дії ВПЛ. Це - синтез імуноглобулінів, комплементу, лізоциму, активність імунних клітин, розташованих в слизовій оболонці та регіонарних лімфатичних вузлах, продукція епітеліальними клітинами імунорегуляторних цитокінів, в тому числі й інтерферонів. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/32270

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Gcanga, Lona. "IL-4/IL-13-inducible lincRNA-MIR99AHG regulates macrophage polarization and promotes intracellular survival of Mycobacterium tuberculosis." Doctoral thesis, Faculty of Health Sciences, 2020. http://hdl.handle.net/11427/32630.

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Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) kills 1.6 million people worldwide every year, and there is an urgent need for targeting host-pathogen interactions as a strategy to reduce mycobacterial resistance to current antimicrobials. Non-coding RNAs are emerging as important regulators of numerous biological processes and avenues for exploitation in host-directed therapeutics. Although long non-coding RNAs (lncRNAs) are abundantly expressed in immune cells, their functional role in gene regulation and bacterial infections remains under-studied. Here, we identify an immunoreg

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Guiter, Chrystelle Leroy Karen Castellano Flavia. "Étude de la voie de signalisation IL-4/IL-13 dans les lymphomes B primitifs du médiastin." S. l. : S. n, 2008. http://doxa.scd.univ-paris12.fr:8080/theses-npd/th0494715.htm.

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35

Silva, Adriana Fernandes. "Participação das citocinas IL-4, IL-13 e IL-33 na resposta imunológica induzida pela infecção experimental por Strongyloides venezuelensis em camundongos." Universidade Federal de Minas Gerais, 2012. http://hdl.handle.net/1843/BUOS-95GJXM.

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Even though the importance of Th2 response in protection against nematodes is well established, the effector mechanism controlling the parasite can be different in each species. It was demonstrated in mice infected with Strongyloides venezuelensis the importance of IL-4R/Stat 6 activation in the induction of a protective response, however the involvement of IL-4, IL-13 and IL- 33 in this mechanism has not yet been established, being the main focus of this work. For this purpose, we used mice deficient in the production of IL-4 (IL-4-/ -) primarily infected or re-infected with S. venezuelensis.

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Duncan, Rachel. "Understanding the molecular basis for MMP-13 repression by IL-4." Thesis, University of Newcastle upon Tyne, 2011. http://hdl.handle.net/10443/1200.

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Cartilage destruction in arthritic disease is characterised by irreversible collagenolysis, resulting in loss of efficient joint function. Of the enzymes capable of hydrolysing native collagen fibrils, matrix metalloproteinase-13 (MMP-13) is the major collagenolytic MMP in osteoarthritis (OA), making this MMP an important diseasemodifying target. Addition of interleukin-1 (IL-1) and oncostatin M (OSM) to bovine nasal cartilage in explant culture results in a synergistic loss of the collagen matrix, accompanied by a dramatic increase in the expression of collagenase enzymes. Interleukin-4 (IL-4

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Lima, Carlos Eduardo de Oliveira. "Níveis séricos de citocinas IL-4, IL-10, IL-12, IL-17 e TNF? e de IgG/IgE aos antígenos dentinários em pacientes submetidos a tratamento ortodôntico." Universidade Estadual de Londrina, 2013. http://www.bibliotecadigital.uel.br/document/?code=vtls000182996.

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Objetivo: A reabsorção radicular decorrente da movimentação dentária induzida é um processo patológico de natureza inflamatória, que pode ser observada em tratamentos ortodônticos. A melhor compreensão de mecanismos imunopatológicos envolvidos nesse processo poderá contribuir para o diagnóstico precoce da reabsorção radicular. O presente estudo teve como objetivo determinar níveis séricos de citocinas e de IgG e IgE aos antígenos dentinários em pacientes submetidos a tratamento ortodôntico. Metodologia: A partir de uma amostra de 34 pacientes, foram analisadas, radiografias periapicais dos inc

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Belo, Vanessa de Almeida. "Expressão de genes da resposta imune em bovinos infestados com carrapatos (Boophilus microplus)." Universidade Federal de Juiz de Fora (UFJF), 2008. https://repositorio.ufjf.br/jspui/handle/ufjf/2841.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-10-14T12:30:34Z No. of bitstreams: 1 vanessadealmeidabelo.pdf: 412659 bytes, checksum: 2be0607436379c3a9ca0f2415972f9be (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-10-22T13:05:05Z (GMT) No. of bitstreams: 1 vanessadealmeidabelo.pdf: 412659 bytes, checksum: 2be0607436379c3a9ca0f2415972f9be (MD5)<br>Made available in DSpace on 2016-10-22T13:05:05Z (GMT). No. of bitstreams: 1 vanessadealmeidabelo.pdf: 412659 bytes, checksum: 2be0607436379c3a9ca0f2415972f9be (MD5) Previous issue

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Oliveira, Lanussy Porfiro de. "Atividade analgésica, anti-inflamatóriae vasorelaxante de dois derivados pirazólicos: 5-[1-(4- fluorfenil)-1H-pirazol-4-IL]-2H-tetrazola(LQFM 020) e 5- [1-(2-fluorofenil)-1H-pirazol-4-IL]-2H-tetrazola (LQFM 039)." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/4876.

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Submitted by Cláudia Bueno (claudiamoura18@gmail.com) on 2015-11-11T20:45:46Z No. of bitstreams: 2 Dissertação - Lanussy Porfiro de Oliveira - 2014.pdf: 1478536 bytes, checksum: 2646f221282c9b288ef2da403ef374d4 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2015-11-12T09:40:17Z (GMT) No. of bitstreams: 2 Dissertação - Lanussy Porfiro de Oliveira - 2014.pdf: 1478536 bytes, checksum: 2646f221282c9b288ef2da403ef374d4 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b

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Stenin, Igor [Verfasser]. "Die Freisetzung von IL-4, IL-13, IL-33, sST2 und Eotaxin 3 nach nasaler Allergenprovokation bei Probanden mit allergischer Rhinitis / Igor Stenin." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2016. http://d-nb.info/1100688846/34.

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Vides, Juliana Peloi [UNESP]. "Expressão gênica das interleucinas IL-4, IL-10, IL-12 e de interferon gama no baço de gatos infectados por Leishmania infantum chagasi." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/126309.

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Made available in DSpace on 2015-08-20T17:09:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-06-25. Added 1 bitstream(s) on 2015-08-20T17:27:09Z : No. of bitstreams: 1 000840958.pdf: 626379 bytes, checksum: cdcf4314b4ef6a4265388d09c2020f3f (MD5)<br>tentativa de compreender a resposta imune de gatos com leishmaniose visceral, o presente estudo teve como objetivo avaliar a expressão gênica das interleucinas IL-4, IL-10, IL-12 e de IFN-γ por reação em cadeia da polimerase em tempo real em amostras de baço de felinos naturalmente acometidos pela doença. Para tanto foram avaliados trê

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Vides, Juliana Peloi. "Expressão gênica das interleucinas IL-4, IL-10, IL-12 e de interferon gama no baço de gatos infectados por Leishmania infantum chagasi /." Araçatuba, 2014. http://hdl.handle.net/11449/126309.

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Resumo: tentativa de compreender a resposta imune de gatos com leishmaniose visceral, o presente estudo teve como objetivo avaliar a expressão gênica das interleucinas IL-4, IL-10, IL-12 e de IFN-γ por reação em cadeia da polimerase em tempo real em amostras de baço de felinos naturalmente acometidos pela doença. Para tanto foram avaliados três grupos de animais; o primeiro e o segundo grupos compostos por seis gatos infectados por Leishmania cada, sintomáticos e assintomáticos, respectivamente; e o terceiro por seis gatos clinicamente hígidos e não infectados. Nos gatos sintomáticos, as expre

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Sarkar, Sujata, Laura Cooney, Peter White, et al. "Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4." BioMed Central, 2009. http://hdl.handle.net/10150/610381.

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INTRODUCTION:Interleukin (IL)-17 plays an important role in the pathogenesis of rheumatoid arthritis and the mouse model collagen-induced arthritis (CIA). Interferon(IFN)-gamma and IL-4 have been shown to suppress Th17 development in vitro, but their potential immunoregulatory roles in vivo are uncertain. The goals of this study were to determine the relationship between Th17 responses and disease severity in CIA and to assess regulation of IL-17 by endogenous IFN-gamma and IL-4.METHODS:DBA1/LacJ mice were immunized with type II collagen in complete Freund's adjuvant (CFA) to induce arthritis,

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Лаврюкова, С. Я., Н. С. Пастерначенко, В. О. Мозгова, О. М. Усиченко та К. М. Усиченко. "Аналіз частоти виявлення деяких поліморфізмів генів цитокінів IL-4, IL-10, TNF у хворих на хронічний гепатит В". Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/45438.

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Хронічний гепатит В (ВГВ) є однією з основних причин хронічних дифузних захворювань печінки. У хворих на ХГВ є високий ризик розвитку цирозу печінки, печінково-клітинної недостатності і гепатоцелюлярної карциноми. Дослідженнями останніх років доведено, що дисбаланс секреції імунорегуляторних цитокінів та регуляції цітокінопосредованої кооперації, проліферації і диференціювання клітин, може бути обумовлений комплексом генів, від яких залежить рівень продукції цитокінів Th1 або Th2 типу. Встановлено, що рівень продукції цитокінів та їх антагоністів, експресія рецепторів до різних цитокінів визна

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Піддубна, Анна Іванівна, Анна Ивановна Поддубная та Anna Ivanivna Piddubna. "IL-4, IL-10 and TNF-α Promotor Gene Polymorphism in North-Eastern Ukrainian HIV-1 Infected Individuals". Thesis, Global HIV Vaccine Enterprise, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32398.

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Вивчено характер розподілу алельних варіантів промотерної ділянки гену IL-4 у позиції -590, IL-10 у позиції -592, TNF-α у позиції -308 у ВІЛ-інфікованих українців Північно-Східного регіону. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/32398<br>Изучен характер распределения аллельных вариантов промотерных участков генов IL-4 в позиции -590, IL-10 в позиции -592, TNF-α в позиции -308 у ВИЧ-инфицированных украинцев Северо-Восточного региона. При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/32398<br>The dist

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Squilloni, Sofia <1993&gt. "Bing Xin tra il 1900 e il 1920: un'analisi storico-biografica a cento anni dal 4 Maggio 1919." Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/15102.

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Il presente lavoro di tesi prende in esame l’infanzia, la giovinezza e una parte della prima produzione letteraria di Bing Xin (pseudonimo di Xie Wanying), scrittrice, poetessa e traduttrice cinese vissuta tra il 1900 e il 1999. Ripercorrendo le tappe fondamentali della prima parte della sua biografia attraverso la traduzione e l’analisi di alcune memorie autobiografiche appartenenti all’età matura della scrittrice, il presente lavoro si propone di analizzare, secondo una prospettiva tematica, i primi racconti della vastissima opera di Bing Xin, collocandoli nel contesto storico in cui vennero

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Bombardieri, Cíntia Raquel. "O circuito p38MAPK/MSK1 influencia o período inicial de diferenciação Th1/2." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-30012008-145520/.

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O sistema imune dos mamíferos forma uma complexa rede de populações celulares especializadas e vias de sinalização extremamente reguladas. Linfócitos T naïve podem diferenciar-se após encontro com o antígeno em pelo menos duas sub-populações distintas, Th1 ou Th2, sendo que o papel do circuito p38MAPK/MSK1 durante este período inicial de ativação não é completamente entendido. Linfócitos T CD4+ naïve humanos foram estimulados in vitro em condições não-polarizantes (Tnp), Th1 ou Th2, na presença de inibidor específico da p38MAPK. As células ativadas e mantidas em condições diferenciadoras Th1 o

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Stupfel, Marine. "Reconnaissance de surfaces de protéines par des foldamères aromatiques." Thesis, Bordeaux 1, 2010. http://www.theses.fr/2010BOR14189/document.

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Les interactions protéine-protéine jouent un rôle primordial dans de nombreux processus biologiques. L’importance de ces interactions a suscité le développement de nouvelles approches thérapeutiques qui ciblent ces complexes protéiques. Nous nous proposons d’inhiber ces interactions en élaborant une stratégie de reconnaissance de surfaces de protéines par des molécules synthétiques de taille intermédiaire, les foldamères d’oligoquinoline. Ces composés se replient en des structures hélicoïdales stables dont chaque élément constitutif peut être fonctionnalisé pour permettre des propriétés de rec

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Lourenço, Roseli Maria de Conti. "Sintese,toxicidade e atividade tripanocida de 3-(4'-bromo-[1,1'-bifenil]-4-il-)-3-(4-x-fenil)-N,N-dimetil-2-propeno-1-amina." [s.n.], 1996. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248924.

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Orientador: Nelson Eduardo Duran Caballero<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-07-21T15:45:09Z (GMT). No. of bitstreams: 1 Lourenco,RoseliMariadeConti_D.pdf: 2708322 bytes, checksum: 794f4d201e21485d488c9944121cadeb (MD5) Previous issue date: 1996<br>Doutorado

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GOMES, JÚNIOR Plínio Pereira. "Dengue em Serra Talhada-PE: vigilância entomológica, epidemiologia e perspectiva molecular." Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/17920.

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Submitted by Natalia de Souza Gonçalves (natalia.goncalves@ufpe.br) on 2016-09-23T14:12:48Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) TESE-Plinio correta.pdf: 2445148 bytes, checksum: af634e24f9f6564ebd9b8c37b5d9c2f8 (MD5)<br>Made available in DSpace on 2016-09-23T14:12:48Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) TESE-Plinio correta.pdf: 2445148 bytes, checksum: af634e24f9f6564ebd9b8c37b5d9c2f8 (MD5) Previous issue date: 2016-03-10<br>Serra Talhada, no sertão Pernambucano, regis

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