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Journal articles on the topic 'IL-6'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Toshiro, Shimamura, Taki Shinsuke, Honda Hideo, Yokota Masataka, Ito Satoru, and Takahara Yoshiyuki. "Analysis of interleukin 6 (IL-6)/IL-6 receptor system using monoclonal anti-IL-6 antibodies." Molecular Immunology 28, no. 11 (1991): 1155–61. http://dx.doi.org/10.1016/0161-5890(91)90001-z.

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2

TAMM, IGOR. "IL-6." Annals of the New York Academy of Sciences 557, no. 1 (2008): 478–89. http://dx.doi.org/10.1111/j.1749-6632.1989.tb24040.x.

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3

Gaillard, O. "Interleukine 6 (IL-6)." Immuno-analyse & Biologie Spécialisée 17, no. 3 (2002): 140–42. http://dx.doi.org/10.1016/s0923-2532(02)01191-2.

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4

Matsuda, Tadashi, and Toshio Hirano. "Interleukin 6 (IL-6)." Biotherapy 2, no. 4 (1990): 363–73. http://dx.doi.org/10.1007/bf02170085.

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5

Hansen, MB, M. Svenson, M. Diamant, C. Ross, and K. Bendtzen. "Interleukin-6 (IL-6) autoantibodies and blood IL-6 measurements [letter]." Blood 85, no. 4 (1995): 1145. http://dx.doi.org/10.1182/blood.v85.4.1145.bloodjournal8541145.

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6

Usha, Prof. "IL-4 and IL-6 in Bronchial Asthma Does IL-6 Plays More Important Role than IL-4? A Preliminary Study." Journal of Medical Science And clinical Research 05, no. 04 (2017): 20446–50. http://dx.doi.org/10.18535/jmscr/v5i4.115.

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7

Van Wagoner, Nicholas J., Jae-Wook Oh, Pavle Repovic, and Etty N. Benveniste. "Interleukin-6 (IL-6) Production by Astrocytes: Autocrine Regulation by IL-6 and the Soluble IL-6 Receptor." Journal of Neuroscience 19, no. 13 (1999): 5236–44. http://dx.doi.org/10.1523/jneurosci.19-13-05236.1999.

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8

Baran, Paul, Rebecca Nitz, Joachim Grötzinger, Jürgen Scheller, and Christoph Garbers. "Minimal Interleukin 6 (IL-6) Receptor Stalk Composition for IL-6 Receptor Shedding and IL-6 Classic Signaling." Journal of Biological Chemistry 288, no. 21 (2013): 14756–68. http://dx.doi.org/10.1074/jbc.m113.466169.

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9

Jostock, Thomas, Guido Blinn, Christoph Renné, Karl-Josef Kallen, Stefan Rose-John, and Jürgen Müllberg. "Immunoadhesins of interleukin-6 and the IL-6/soluble IL-6R fusion protein hyper-IL-6." Journal of Immunological Methods 223, no. 2 (1999): 171–83. http://dx.doi.org/10.1016/s0022-1759(98)00218-x.

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10

Pooran, Nakechand, Anant Indaram, Pankaj Singh, and Simmy Bank. "Cytokines (IL-6, IL-8, TNF)." Journal of Clinical Gastroenterology 37, no. 3 (2003): 263–66. http://dx.doi.org/10.1097/00004836-200309000-00013.

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11

Nishimoto, Norihiro. "6. IL-6 Inhibitors for Treatment of Rheumatoid Arthritis." Nihon Naika Gakkai Zasshi 97, no. 10 (2008): 2413–17. http://dx.doi.org/10.2169/naika.97.2413.

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12

SNICK, JACQUES, JEAN-CHRISTOPHE RENAULD, RICHARD J. SIMPSON, CATHERINE UYTTENHOVE, and ANNE VINK. "Mouse IL-6." Annals of the New York Academy of Sciences 557, no. 1 (2008): 206–14. http://dx.doi.org/10.1111/j.1749-6632.1989.tb24014.x.

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13

Hodgson, John. "Patenting IL-6." Nature Biotechnology 10, no. 1 (1992): 16. http://dx.doi.org/10.1038/nbt0192-16.

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14

McInnes, Iain. "Considering IL-6." Considerations in Medicine 2, no. 1 (2018): 1. http://dx.doi.org/10.1136/conmed-2018-000006.

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15

Metz, Silke, Monique Wiesinger, Michael Vogt, et al. "Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP." Journal of Biological Chemistry 282, no. 2 (2006): 1238–48. http://dx.doi.org/10.1074/jbc.m606885200.

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16

De Benedetti, F., M. Massa, P. Pignatti, S. Albani, D. Novick, and A. Martini. "Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis." Journal of Clinical Investigation 93, no. 5 (1994): 2114–19. http://dx.doi.org/10.1172/jci117206.

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17

Nakajima, Ayako. "2. IL-6 Inhibitor." Nihon Naika Gakkai Zasshi 100, no. 10 (2011): 2972–78. http://dx.doi.org/10.2169/naika.100.2972.

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18

Szot, Patricia, Allyn Franklin, Dianne P. Figlewicz, et al. "Multiple lipopolysaccharide (LPS) injections alter interleukin 6 (IL-6), IL-7, IL-10 and IL-6 and IL-7 receptor mRNA in CNS and spleen." Neuroscience 355 (July 2017): 9–21. http://dx.doi.org/10.1016/j.neuroscience.2017.04.028.

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19

Baran, Paul, Selina Hansen, Georg H. Waetzig, et al. "The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling." Journal of Biological Chemistry 293, no. 18 (2018): 6762–75. http://dx.doi.org/10.1074/jbc.ra117.001163.

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20

Uchiyama, Yasushi, Hiroto Yoshida, Nobuo Koike, et al. "Anti-IL-6 receptor antibody increases blood IL-6 level via the blockade of IL-6 clearance, but not via the induction of IL-6 production." International Immunopharmacology 8, no. 11 (2008): 1595–601. http://dx.doi.org/10.1016/j.intimp.2008.07.002.

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21

HIRANO, TOSHIO. "Interleukin 6 (IL-6) and disease." Japanese Journal of Clinical Immunology 13, no. 5 (1990): 444–45. http://dx.doi.org/10.2177/jsci.13.444.

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22

Gumiela, Dorota. "The influence of interleukin-6 on the course of ovarian cancer." MicroMedicine 7, no. 1 (2019): 1–4. https://doi.org/10.5281/zenodo.2559560.

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In Poland, in 2015, according to the National Cancer Registry (NCR), cancer was diagnosed among 163 281 people, including 81 632 women and 81 649 men. Ovarian cancer in 2015 affected 3% of women who had cancer. Interleukin 6 is a glycoprotein that consists of 212 amino acids. The gene encoding interleukin 6 is located on chromosome 7 adjacent to the gene LOC541472 and RSP26P32 in 7p15.3. The sources of interleukin 6 include tumor cells and macrophages that are secreted by bone marrow cells as a result of a process in which monoblasts are transformed into the promonocyte in the bone marrow, and

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23

Schöbitz, Bernd, Gita Pezeshki, Thomas Pohl, et al. "Soluble interleukin‐6 (IL‐6) receptor augments central effects of IL‐6 in vivo." FASEB Journal 9, no. 8 (1995): 659–64. http://dx.doi.org/10.1096/fasebj.9.8.7768358.

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24

Hansen, Morten Bagge, Morten Svenson, Kathrine Abell, Kiyoshi Yasukawa, Marcus Diamant, and Klaus Bendtzen. "Influence of interleukin-6 (IL-6) autoantibodies on IL-6 binding to cellular receptors." European Journal of Immunology 25, no. 2 (1995): 348–54. http://dx.doi.org/10.1002/eji.1830250207.

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25

Rajkumar, Deepak, Kumar Sumit, and Prasad Yadav Naresh. "A Prospective Analytical Assessment of Cardiac Failure and its Prognostication with 3C: Reactive Protein as a Marker of Severity." International Journal of Pharmaceutical and Clinical Research 14, no. 7 (2022): 546–52. https://doi.org/10.5281/zenodo.13371518.

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<strong>Aim: </strong>To evaluate the cardiac failure and its prognostication with 3C: Reactive protein as a marker of severity. <strong>Material & Methods: </strong>The cross-sectional analytical study was conducted in the Department of Medicine, Government Medical College, Bettiah, Bihar, India. Chagas disease was confirmed by 3 serological tests: direct agglutination, immunofluorescence, and enzyme- linked immunoassay (ELISA) and patients with 2 or more positive assays were accepted as positive. <strong>Results: </strong>The multiple regression analysis found no

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26

Deng-Ho, Yang. "The Biological Effects of Interleukin-6 and Their Clinical Applications in Autoimmune Diseases and Cancers." Rheumatica Acta: Open Access 1, no. 1 (2017): 006–16. https://doi.org/10.17352/aroa.000003.

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Interleukin-6 (IL-6) is one of the pro-infl ammatory cytokines involved in pathogenesis of various  autoimmune and chronic infl ammatory diseases. IL-6 through binding to its cellular receptor can transduce both classical- and trans-signaling pathways. Overproduction of circulating IL-6 can be  detected in patients with different autoimmune diseases. Tocilizumab, a humanized monoclonal antibody against IL-6 receptor, can block IL-6-mediated signaling and has been approved for the treatment of rheumatoid arthritis and Castleman’s disease. Besides, expression of IL-6 may promote

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27

Rose-John, Stefan. "IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6." International Journal of Biological Sciences 8, no. 9 (2012): 1237–47. http://dx.doi.org/10.7150/ijbs.4989.

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28

Suzuki, H., H. Takemura, K. Yoshizaki, et al. "IL-6-anti-IL-6 autoantibody complexes with IL-6 activity in sera from some patients with systemic sclerosis." Journal of Immunology 152, no. 2 (1994): 935–42. http://dx.doi.org/10.4049/jimmunol.152.2.935.

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Abstract Anti-IL-6 IgG autoantibodies, often found in sera from patients with systemic sclerosis, may increase to the level sufficient to bind significant amounts of IL-6 in serum. In our study of the role of anti-IL-6 autoantibodies in serum, we found that some sera with the autoantibodies possessed considerably higher IL-6 levels (more than 100 pg/ml) compared with most of sera without the autoantibodies. Size-exclusion HPLC of the sera with these autoantibodies demonstrated that a significant part of the serum IL-6 activity was attributable to circulating IL-6-anti-IL-6 autoantibody complex

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29

Baiocchi, Marta, Isabella Marcucci, Stefan Rose-John, Ottaviano Serlupi-Crescenzi, and Mauro Biffoni. "AN IL-6/IL-6 SOLUBLE RECEPTOR (IL-6R) HYBRID PROTEIN (H-IL-6) INDUCES EPO-INDEPENDENT ERYTHROID DIFFERENTIATION IN HUMAN CD34+CELLS." Cytokine 12, no. 9 (2000): 1395–99. http://dx.doi.org/10.1006/cyto.2000.0723.

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30

Pizzi, Marina, Ilenia Sarnico, Flora Boroni, et al. "Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices." Molecular and Cellular Neuroscience 25, no. 2 (2004): 301–11. http://dx.doi.org/10.1016/j.mcn.2003.10.022.

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31

Park, Sung Tae. "상대적 운동 강도가 형철 IL-2, IL-6 농도에 미치는 효과". Journal of Sport and Leisure Studies 23 (31 травня 2005): 319–27. http://dx.doi.org/10.51979/kssls.2005.05.23.319.

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32

Tanaka, Toshio, Masashi Narazaki, and Tadamitsu Kishimoto. "Interleukin (IL-6) Immunotherapy." Cold Spring Harbor Perspectives in Biology 10, no. 8 (2017): a028456. http://dx.doi.org/10.1101/cshperspect.a028456.

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33

Hoene, Miriam, Louise Fritsche, Rainer Lehmann, et al. "Running without IL-6." Medicine & Science in Sports & Exercise 40, Supplement (2008): S192. http://dx.doi.org/10.1249/01.mss.0000322290.16416.c4.

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34

Rose-John, Stefan, and Markus F. Neurath. "IL-6 trans-Signaling." Immunity 20, no. 1 (2004): 2–4. http://dx.doi.org/10.1016/s1074-7613(04)00003-2.

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35

Gutierrez, G., G. Junovich, V. Dubinsky, and T. Gentile. "IL-6 in reproduction." Journal of Reproductive Immunology 75, no. 1 (2007): A4—A5. http://dx.doi.org/10.1016/j.jri.2007.06.007.

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36

Upadhyaya, Smitha, Vinitha Kadamkode, Rafi Mahammed, Chandraprabha Doraiswami, and Gautam Banerjee. "Adiponectin and IL-6." Adipocyte 3, no. 1 (2013): 39–45. http://dx.doi.org/10.4161/adip.26553.

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37

Malberg, Kurt. "Psychostress und IL-6." Allergo Journal 20, no. 3 (2011): 134. http://dx.doi.org/10.1007/bf03362453.

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38

Ding, W., L. L. Stohl, V. Isak, J. A. Wagner, Z. Bulmer, and R. D. Granstein. "006 IL-6 enhances IL-6 expression by epidermal langerhans cells (LCs)." Journal of Investigative Dermatology 142, no. 8 (2022): S1. http://dx.doi.org/10.1016/j.jid.2022.05.060.

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39

Potere, Nicola, Alberto Batticciotto, Alessandra Vecchié, et al. "The role of IL-6 and IL-6 blockade in COVID-19." Expert Review of Clinical Immunology 17, no. 6 (2021): 601–18. http://dx.doi.org/10.1080/1744666x.2021.1919086.

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40

Müllberg, Jürgen, Till Geib, Thomas Jostock, et al. "IL-6 Receptor Independent Stimulation of Human gp130 by Viral IL-6." Journal of Immunology 164, no. 9 (2000): 4672–77. http://dx.doi.org/10.4049/jimmunol.164.9.4672.

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41

Nanki, Toshihiro. "Advances of treatment with IL-6/IL-6 receptor inhibitors for RA." Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (2018): SY61–2. http://dx.doi.org/10.1254/jpssuppl.wcp2018.0_sy61-2.

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42

Suzuki, H., K. Yasukawa, T. Saito, et al. "Anti-murine IL-6 receptor antibody inhibits IL-6 effects in vivo." Immunology Letters 30, no. 1 (1991): 17–22. http://dx.doi.org/10.1016/0165-2478(91)90083-m.

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43

Li, Yan, Carl-Magnus Bäckesjö, Lars-Arne Haldosén, and Urban Lindgren. "IL-6 receptor expression and IL-6 effects change during osteoblast differentiation." Cytokine 43, no. 2 (2008): 165–73. http://dx.doi.org/10.1016/j.cyto.2008.05.007.

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44

Osborne, Julie, Patrick S. Moore, and Yuan Chang. "KSHV-encoded viral IL-6 activates multiple human IL-6 signaling pathways." Human Immunology 60, no. 10 (1999): 921–27. http://dx.doi.org/10.1016/s0198-8859(99)00083-x.

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45

Gadient, R. A., and U. Otten. "Postnatal expression of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) mRNAs in rat sympathetic and sensory ganglia." Brain Research 724, no. 1 (1996): 41–46. http://dx.doi.org/10.1016/0006-8993(96)00264-8.

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46

Gadient, R. A., A. Lachmund, K. Unsicker, and U. Otten. "Expression of interleukin-6 (IL-6) and IL-6 receptor mRNAs in rat adrenal medulla." Neuroscience Letters 194, no. 1-2 (1995): 17–20. http://dx.doi.org/10.1016/0304-3940(95)11708-5.

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47

Hoyland, Judith A., A. J. Freemont, and P. T. Sharpe. "Interleukin-6, IL-6 receptor, and IL-6 nuclear factor gene expression in paget's disease." Journal of Bone and Mineral Research 9, no. 1 (2009): 75–80. http://dx.doi.org/10.1002/jbmr.5650090111.

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48

Inoue, K., H. Sugiyama, H. Ogawa, et al. "Expression of the interleukin-6 (IL-6), IL-6 receptor, and gp130 genes in acute leukemia." Blood 84, no. 8 (1994): 2672–80. http://dx.doi.org/10.1182/blood.v84.8.2672.2672.

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Abstract Expression patterns of interleukin-6 (IL-6), IL-6 receptor (IL-6R), and gp130 genes in 39 patients with acute myeloid leukemia (AML), in 23 patients with acute lymphoblastic leukemia (ALL), and in 7 patients with acute mixed lineage leukemia (AMLL) were studied by quantitative reverse transcriptase-polymerase chain reaction. Significant levels of IL-6 were expressed in 8 (21%) of 39 AML patients and in 2 (29%) of 7 AMLL patients, whereas in ALL, the expression of IL-6 was almost negligible. IL-6R was expressed in all patients with AML and AMLL, whereas only half of ALL patients expres

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49

Inoue, K., H. Sugiyama, H. Ogawa, et al. "Expression of the interleukin-6 (IL-6), IL-6 receptor, and gp130 genes in acute leukemia." Blood 84, no. 8 (1994): 2672–80. http://dx.doi.org/10.1182/blood.v84.8.2672.bloodjournal8482672.

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Expression patterns of interleukin-6 (IL-6), IL-6 receptor (IL-6R), and gp130 genes in 39 patients with acute myeloid leukemia (AML), in 23 patients with acute lymphoblastic leukemia (ALL), and in 7 patients with acute mixed lineage leukemia (AMLL) were studied by quantitative reverse transcriptase-polymerase chain reaction. Significant levels of IL-6 were expressed in 8 (21%) of 39 AML patients and in 2 (29%) of 7 AMLL patients, whereas in ALL, the expression of IL-6 was almost negligible. IL-6R was expressed in all patients with AML and AMLL, whereas only half of ALL patients expressed low l

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50

Nemunaitis, J., DF Andrews, DY Mochizuki, MB Lilly, and JW Singer. "Human marrow stromal cells: response to interleukin-6 (IL-6) and control of IL-6 expression." Blood 74, no. 6 (1989): 1929–35. http://dx.doi.org/10.1182/blood.v74.6.1929.1929.

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Abstract Production of interleukin-6 (IL-6) by marrow stromal cells from human long-term marrow cultures and from stromal cells transformed with simian virus 40 was examined. As with other cultured mesenchymal cells, unstimulated stromal cells produced undetectable amounts of IL-6 mRNA when assayed by Northern blots. However, within 30 minutes after exposure of transformed marrow stromal cells to the inflammatory mediators, recombinant human interleukin-1 alpha (IL-1 alpha) or recombinant human tumor necrosis factor alpha (TNF alpha), significant increases in IL-6 expression were observed. The

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