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Journal articles on the topic 'IMAT'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

Abd Alamer, Iman Sabah, Ali Athafah Tomah, Bin Li, and Jing-Ze Zhang. "Isolation, Identification and Characterization of Rhizobacteria Strains for Biological Control of Bacterial Wilt (Ralstonia solanacearum) of Eggplant in China." Agriculture 10, no. 2 (2020): 37. http://dx.doi.org/10.3390/agriculture10020037.

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Bacterial wilt of eggplant is the most destructive disease caused by Ralstonia solanacearum throughout the world. Eleven bacterial strains with high antagonistic activity were obtained from 245 rhizobacteria. Based on analysis of morphology, 16S rRNA sequences, fatty acid profiles, gyrA and rpoB genes, they were identified as Pseudomonas putida (IMA3), Paenibacillus polymyxa (IMA5), Bacillus cereus (IMA4, IMA7 and IMA11) and the “operational group Bacillus amyloliquefaciens” (IMA1, IMA2, IMA6, IMA8, IMA9 and IMA10). The lipopeptide compounds produced by each strain also were determined. The bi

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Bogie, Kath M., Katelyn Schwartz, Youjin Li, Shengxuan Wang, Wei Dai, and Jiayang Sun. "Exploring adipogenic and myogenic circulatory biomarkers of recurrent pressure injury risk for persons with spinal cord injury." Journal of Circulating Biomarkers 6, no. 1 (2020): 1–7. http://dx.doi.org/10.33393/jcb.2020.2121.

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Purpose: To investigate linkages between circulatory adipogenic and myogenic biomarkers, gluteal intramuscular adipose tissue (IMAT), and pressure injury (PrI) history following spinal cord injury (SCI). Methods: This is an observational repeated-measures study of 30 individuals with SCI. Whole blood was collected regularly over 2-3 years. Circulatory adipogenic and myogenic gene expression was determined. IMAT was defined as above/below 15% (IMATd) or percentage (IMAT%). PrI history was defined as recurrent PrI (RPrI) or PrI number (nPrI). Model development used R packages (version 3.5.

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Tuttle, Lori J., David R. Sinacore, and Michael J. Mueller. "Intermuscular Adipose Tissue Is Muscle Specific and Associated with Poor Functional Performance." Journal of Aging Research 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/172957.

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Purpose. People with obesity, diabetes, and peripheral neuropathy have high levels of intermuscular adipose tissue (IMAT) volume which has been inversely related to physical function. We determined if IMAT is muscle specific, if calf IMAT is different between a healthy obese group (HO), a group with diabetes mellitus (D), and a group with diabetes mellitus and peripheral neuropathy (DN), and if IMAT volume or the ratio of IMAT/muscle volume is related to physical function in these groups.Methods. 10 healthy obese people, 11 with type 2 diabetes, 24 with diabetes and peripheral neuropathy, had

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Sachs, Stephan, Simona Zarini, Darcy E. Kahn, et al. "Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans." American Journal of Physiology-Endocrinology and Metabolism 316, no. 5 (2019): E866—E879. http://dx.doi.org/10.1152/ajpendo.00243.2018.

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Intermuscular adipose tissue (IMAT) is negatively related to insulin sensitivity, but a causal role of IMAT in the development of insulin resistance is unknown. IMAT was sampled in humans to test for the ability to induce insulin resistance in vitro and characterize gene expression to uncover how IMAT may promote skeletal muscle insulin resistance. Human primary muscle cells were incubated with conditioned media from IMAT, visceral (VAT), or subcutaneous adipose tissue (SAT) to evaluate changes in insulin sensitivity. RNAseq analysis was performed on IMAT with gene expression compared with ske

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Bergia, Robert E., Jung Eun Kim, and Wayne W. Campbell. "Differential Relationship between Intermuscular Adipose Depots with Indices of Cardiometabolic Health." International Journal of Endocrinology 2018 (September 4, 2018): 1–8. http://dx.doi.org/10.1155/2018/2751250.

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Background. Globally, accumulation of intermuscular adipose tissue (IMAT) is positively associated with insulin resistance. Whether this association is observed consistently in different skeletal muscles and encompasses other markers of cardiometabolic health is not well known. Objectives. The purpose of this secondary analysis study was to investigate associations among thigh or calf IMAT stores and indices of cardiometabolic health in adults who are overweight and obese participating in dietary interventions. A subset of calf data was analyzed to assess relations between IMAT in the gastrocn

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Tegeler, Alexandra P., Jean Fiallo-Diez, Tainara Michelotti, et al. "32 Depot-Specific Transcriptome and Adipocyte Metabolism in Intramuscular and Subcutaneous Adipose Tissue in Beef Cattle." Journal of Animal Science 101, Supplement_1 (2023): 16–17. http://dx.doi.org/10.1093/jas/skad068.019.

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Abstract Intramuscular adipose tissue (IMAT; marbling) deposition is the primary determination of beef quality grade in the U.S. While finishing diets increase marbling, they also increase subcutaneous adipose tissue (SAT) accumulation, leading to excessive fattening and economic losses due to ‘waste fat’. Our objective was to investigate the IMAT and SAT-specific transcriptional profile and adipocyte function in vitro. A better understanding of the mechanisms underlying IMAT and SAT-specific characteristics will help to identify molecular and cellular molecules for developing targeted strateg

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Jacobs, Janelle L., Robin L. Marcus, Glen Morrell, and Paul LaStayo. "Resistance Exercise with Older Fallers: Its Impact on Intermuscular Adipose Tissue." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/398960.

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Objective. Greater skeletal muscle fat infiltration occurs with age and contributes to numerous negative health outcomes. The primary purpose was to determine whether intermuscular adipose tissue (IMAT) can be influenced by an exercise intervention and if a greater reduction in IMAT occurs with eccentric versus traditional resistance training.Methods. Seventy-seven older adults (age 75.5 ± 6.8) with multiple comorbidities and a history of falling completed a three-month exercise intervention paired with either eccentric or traditional resistance training. MRI of the mid-thigh was examined at t

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Durheim, Michael T., Cris A. Slentz, Lori A. Bateman, Stephanie K. Mabe, and William E. Kraus. "Relationships between exercise-induced reductions in thigh intermuscular adipose tissue, changes in lipoprotein particle size, and visceral adiposity." American Journal of Physiology-Endocrinology and Metabolism 295, no. 2 (2008): E407—E412. http://dx.doi.org/10.1152/ajpendo.90397.2008.

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Small LDL and HDL particle size are characteristic of a proatherogenic lipoprotein profile. Aerobic exercise increases these particle sizes. Although visceral adipose tissue (VAT) has been strongly linked with dyslipidemia, the importance of intermuscular adipose tissue (IMAT) to dyslipidemia and exercise responses is less well understood. We measured exercise-associated changes in thigh IMAT and VAT and examined their relationships with changes in LDL and HDL particle size. Sedentary, dyslipidemic, overweight subjects ( n = 73) completed 8–9 mo of aerobic training. Linear regression models we

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Kahn, Darcy, Simona Zarini, Emily Macias, et al. "4126 Intermuscular adipose tissue secretes pro-inflammatory, extracellular matrix, and lipid signals related to insulin resistance and type 2 diabetes." Journal of Clinical and Translational Science 4, s1 (2020): 9. http://dx.doi.org/10.1017/cts.2020.73.

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OBJECTIVES/GOALS: Intermuscular adipose tissue (IMAT) has been associated with insulin resistance and type 2 diabetes, yet mechanistic studies addressing the functional role of IMAT are lacking. The aim of this work was to identify novel mechanisms by which IMAT may directly impact skeletal muscle metabolism. METHODS/STUDY POPULATION: We quantified the secretome of IMAT, subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) to determine if there are differences between depots in the secretion of cytokines, eicosanoids, FFAs and proteins that influence metabolic function. SAT and

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Yaskolka Meir, Anat, Ilan Shelef, Dan Schwarzfuchs, et al. "Intermuscular adipose tissue and thigh muscle area dynamics during an 18-month randomized weight loss trial." Journal of Applied Physiology 121, no. 2 (2016): 518–27. http://dx.doi.org/10.1152/japplphysiol.00309.2016.

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It remains unclear whether intermuscular adipose tissue (IMAT) has any metabolic influence or whether it is merely a marker of abnormalities, as well as what are the effects of specific lifestyle strategies for weight loss on the dynamics of both IMAT and thigh muscle area (TMA). We followed the trajectory of IMAT and TMA during 18-mo lifestyle intervention among 278 sedentary participants with abdominal obesity, using magnetic resonance imaging. We measured the resting metabolic rate (RMR) by an indirect calorimeter. Among 273 eligible participants (47.8 ± 9.3 yr of age), the mean IMAT was 9.

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Konopka, Adam R., Christopher A. Wolff, Miranda K. Suer, and Matthew P. Harber. "Relationship between intermuscular adipose tissue infiltration and myostatin before and after aerobic exercise training." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 315, no. 3 (2018): R461—R468. http://dx.doi.org/10.1152/ajpregu.00030.2018.

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Intermuscular adipose tissue (IMAT) is associated with impaired skeletal muscle contractile and metabolic function. Myostatin and downstream signaling proteins such as cyclin-dependent kinase 2 (CDK2) contribute to the regulation of adipose and skeletal muscle mass in cell culture and animals models, but this relationship remains incompletely understood in humans. The purpose of this study was to determine if the infiltration of IMAT was associated with skeletal muscle myostatin and downstream proteins before and after 12 wk of aerobic exercise training (AET) in healthy older women (OW; 69 ± 2

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Gamboa, Jorge Luis, Daniel Carranza-León, Rachelle Crescenzi, et al. "Intermuscular adipose tissue in patients with systemic lupus erythematosus." Lupus Science & Medicine 9, no. 1 (2022): e000756. http://dx.doi.org/10.1136/lupus-2022-000756.

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ObjectivePatients with SLE frequently have debilitating fatigue and reduced physical activity. Intermuscular adipose tissue (IMAT) accumulation is associated with reduced physical exercise capacity. We hypothesised that IMAT is increased in patients with SLE and associated with increased fatigue, reduced physical activity and increased inflammation.MethodsIn a cross-sectional study, 23 patients with SLE and 28 control participants were evaluated. IMAT was measured in the calf muscles using sequentialT1-weighted MRI. Patient-reported physical activity and fatigue were measured and a multiplex p

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Hassan, Saria, Alexis Cooke, Haneefa Saleem, Dorothy Mushi, Jessie Mbwambo, and Barrot Lambdin. "Evaluating the Integrated Methadone and Anti-Retroviral Therapy Strategy in Tanzania Using the RE-AIM Framework." International Journal of Environmental Research and Public Health 16, no. 5 (2019): 728. http://dx.doi.org/10.3390/ijerph16050728.

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There are an estimated 50,000 people who inject drugs in Tanzania, with an HIV prevalence in this population of 42%. The Integrated Methadone and Anti-Retroviral Therapy (IMAT) strategy was developed to integrate HIV services into an opioid treatment program (OTP) in sub-Saharan Africa and increase anti-retroviral therapy (ART) initiation rates. In this paper, we evaluate the IMAT strategy using an implementation science framework to inform future care integration efforts in the region. IMAT centralized HIV services into an OTP clinic in Dar Es Salaam, Tanzania: HIV diagnosis, ART initiation,

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Lanza, Marcel, Vicki Gray, Alice Ryan, Will Perez, and Odessa Addison. "Role of Intramuscular Fat and Lean Muscle in Surface Electromyography Amplitude of the Gluteus Medius in Older Adults." Innovation in Aging 4, Supplement_1 (2020): 127. http://dx.doi.org/10.1093/geroni/igaa057.417.

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Abstract Surface electromyography (sEMG) is frequently used to assess muscle activation in older individuals. Subcutaneous fat is one well-known factor that influences sEMG amplitude. The amount of intramuscular fat (IMAT) may negatively impact the muscles ability to produce force with aging, while high density lean tissue (HDL; fat free muscle) has an opposite effect. However, influence of IMAT or HDL on sEMG amplitude remains unclear. Thus, the aim was to investigate the influence of IMAT and HDL on sEMG amplitude of the gluteus medius (GM) muscle during a maximal voluntary isometric contrac

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Sparks, Lauren Marie, Bret H. Goodpaster, and Bryan C. Bergman. "The Metabolic Significance of Intermuscular Adipose Tissue: Is IMAT a Friend or a Foe to Metabolic Health?" Diabetes 70, no. 11 (2021): 2457–67. http://dx.doi.org/10.2337/dbi19-0006.

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Adipose tissues are not homogeneous and show site-specific properties. An elusive and understudied adipose tissue depot, most likely due to its limited accessibility, is the intermuscular adipose tissue (IMAT) depot. Adipose tissue is a pliable organ with the ability to adapt to its physiological context, yet whether that adaptation is harmful or beneficial in the IMAT depot remains to be explored in humans. Potential reasons for IMAT accumulation in humans being deleterious or beneficial include 1) sex and related circulating hormone levels, 2) race and ethnicity, and 3) lifestyle factors (e.

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Suka Aryana, I. Gusti Putu, Ivana Beatrice Paulus, Sanjay Kalra, et al. "The Important Role of Intermuscular Adipose Tissue on Metabolic Changes Interconnecting Obesity, Ageing and Exercise: A Systematic Review." European Endocrinology 19, no. 1 (2023): 54. http://dx.doi.org/10.17925/ee.2023.19.1.54.

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As age increases, adipose tissue infiltrates muscle tissue and leads to sarcopenia. When excessive accumulation of adipose tissue accompanied progressive decrease in lean body mass especially visceral fat, termed as sarcopenic obesity (SO) and related metabolic intermuscular adipose tissue (IMAT) is an ectopic tissue found between muscle groups, and is distinct from subcutaneous adipose tissue. Until now, the association between IMAT and metabolic health was not understood. This study is the first systematic review assessing the association between IMAT and metabolic health. The PubMed, Scienc

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Tegeler, Alexandra P., Hunter R. Ford, Jean Franco Fiallo-Diez, et al. "Transcriptome and Cellular Evidence of Depot-Specific Function in Beef Cattle Intramuscular, Subcutaneous, and Visceral Adipose Tissues." Biology 14, no. 7 (2025): 848. https://doi.org/10.3390/biology14070848.

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Deposition of intramuscular adipose tissue (IMAT) is the primary determinant for beef quality grade in the U.S. Accumulation of subcutaneous (SCAT) and visceral (VIAT) adipose tissue precedes that of IMAT and often leads to excessive adiposity in beef cattle. Approaches to increase marbling while limiting subcutaneous and visceral adiposity are limited. Our objective is to define the depot-specific transcriptome profile and adipocyte function in IMAT, SCAT, and VIAT in beef steers. Transcriptomics revealed the upregulation of adipogenic and lipogenic genes in SCAT and VIAT vs. IMAT. Functional

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Popkonstantinov, Kazimir. "Zaklinatelni molitvi v'rhu olovni amuleti ot srednovekovna B'lgarija i paralelite im v trebnici ot srednovekovna S'rbija." Zbornik radova Vizantoloskog instituta, no. 46 (2009): 341–50. http://dx.doi.org/10.2298/zrvi0946341p.

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(bugarski) Prez poslednite petnadeset godini v B'lgarija bjaha otkriti okolo osemdeset olovni amuleti s's zaklinatelni, evangelski, psaltirni tekstove na gr'cki, starob'lgarski (s kirilsko i glagolicesko pismo). Te doprinasjat za obogatjavane na nasite predstavi za duhovnija zivot na srednovekovnija b'lgarin, t'j kato po-goljamata cast ot tjah sa ot X-XI v. Znacitelen interes predstavljavat cast ot tezi tekstove, koito imat mnogo blizko paraleli s redica zaklinatelni molitvi v Trebnici ot XV-XVI v. Sred tjah sa i sr'bski Trebnici ot tozi period, cast ot koito imah v'zmoznost da izsledvam v r'k

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Tegeler, Alexandra P., Jean Fiallo-Diez, Tainara Michelotti, et al. "PSIII-20 Transcriptional and Functional Analyses of Intramuscular, Subcutaneous, and Visceral Adipose Tissue in Finished Beef Cattle." Journal of Animal Science 101, Supplement_3 (2023): 381–82. http://dx.doi.org/10.1093/jas/skad281.452.

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Abstract Intramuscular adipose tissue (IMAT; marbling) deposition is a highly desired trait in beef cattle. Unlike excessive subcutaneous (SCAT) and visceral (VIAT) adipose tissue, which have relatively low value, increased marbling is associated with meat sensory traits and is a primary factor influencing beef quality grading in the U.S. However, this trait is difficult to achieve. Our objective was to assess depot-specific characteristics and gene profile of IMAT, SCAT, and VIAT in beef cattle. IMAT and SCAT samples from the longissimus muscle (9-11th ribs), and VIAT from the greater omentum

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Villedon de Naide, Marc, Bruno Pereira, Daniel Courteix, et al. "Assessment of Intramuscular Fat and Correlation with Body Composition in Patients with Rheumatoid Arthritis and Spondyloarthritis: A Pilot Study." Nutrients 13, no. 12 (2021): 4533. http://dx.doi.org/10.3390/nu13124533.

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Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are associated with changes in body composition. Ectopic intramuscular fat (IMAT) may alter muscle function and contribute to cardiometabolic disorders. In a pilot study, we analyzed IMAT in the calf with peripheral quantitative computed tomography (pQCT) and examined correlations between IMAT quantity and body composition parameters. In 20 patients with active RA and 23 with active SpA, IMAT was correlated with visceral fat (VAT; r = 0.5143 and 0.6314, respectively; p < 0.05) and total lean mass (r = 0.5414 and 0.8132, respectively; p &

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Chow, Simon Kwoon-Ho, Marloes van Mourik, Vivian Wing-Yin Hung, et al. "HR-pQCT for the Evaluation of Muscle Quality and Intramuscular Fat Infiltration in Ageing Skeletal Muscle." Journal of Personalized Medicine 12, no. 6 (2022): 1016. http://dx.doi.org/10.3390/jpm12061016.

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Myosteatosis is the infiltration of fat in skeletal muscle during the onset of sarcopenia. The quantification of intramuscular adipose tissue (IMAT) can be a feasible imaging modality for the clinical assessment of myosteatosis, important for the early identification of sarcopenia patients and timely intervention decisions. There is currently no standardized method or consensus for such an application. The aim of this study was to develop a method for the detection and analysis of IMAT in clinical HR-pQCT images of the distal tibia to evaluate skeletal muscle during the ageing process, validat

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Ruan, Xiang Yan, Dympna Gallagher, Tamara Harris, et al. "Estimating whole body intermuscular adipose tissue from single cross-sectional magnetic resonance images." Journal of Applied Physiology 102, no. 2 (2007): 748–54. http://dx.doi.org/10.1152/japplphysiol.00304.2006.

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Intermuscular adipose tissue (IMAT), a novel fat depot linked with metabolic abnormalities, has been measured by whole body MRI. The cross-sectional slice location with the strongest relation to total body IMAT volume has not been established. The aim was to determine the predictive value of each slice location and which slice locations provide the best estimates of whole body IMAT. MRI quantified total adipose tissue of which IMAT, defined as adipose tissue visible within the boundary of the muscle fascia, is a subcomponent. Single-slice IMAT areas were calculated for the calf, thigh, buttock

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Murphy, Joan C., Jennifer L. McDaniel, Katherine Mora, Dennis T. Villareal, Luigi Fontana, and Edward P. Weiss. "Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss compared with calorie restriction." Journal of Applied Physiology 112, no. 1 (2012): 79–85. http://dx.doi.org/10.1152/japplphysiol.00355.2011.

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Intermuscular adipose tissue (IMAT) and visceral adipose tissue (VAT) are associated with insulin resistance. We sought to determine whether exercise-induced weight loss (EX) results in greater reductions in IMAT and VAT compared with similar weight loss induced by calorie restriction (CR) and whether these changes are associated with improvements in glucoregulation. Sedentary men and women (50–60 yr; body mass index of 23.5–29.9 kg/m2) were randomized to 1 yr of CR ( n = 17), EX ( n = 16), or a control group (CON; n = 6). Bilateral thigh IMAT and VAT volumes were quantified using multi-slice

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Quinn, Joseph. "Countdown to IMAT 2023." Metallography, Microstructure, and Analysis 12, no. 1 (2023): 3. http://dx.doi.org/10.1007/s13632-023-00931-9.

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Yim, Jung-Eun, Stanley Heshka, Jeanine B. Albu, Steven Heymsfield, and Dympna Gallagher. "Femoral-gluteal subcutaneous and intermuscular adipose tissues have independent and opposing relationships with CVD risk." Journal of Applied Physiology 104, no. 3 (2008): 700–707. http://dx.doi.org/10.1152/japplphysiol.01035.2007.

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Femoral-gluteal adipose tissue (AT) may be cardioprotective through fatty acids uptake. Femoral-gluteal AT has previously been defined as leg fat measured by dual energy x-ray absorptiometry (DXA); however, subcutaneous adipose tissue (SAT) and intermuscular adipose tissue (IMAT) are inseparable using DXA. This study investigated the independent relationships between femoral-gluteal SAT, femoral-gluteal IMAT, and cardiovascular disease (CVD) risk factors [fasting serum measures of glucose, total cholesterol (TC), high density lipoprotein cholesterol (HDLC), triglycerides (TG) and insulin] and

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Hassler, Eva Maria, Hannes Deutschmann, Gunter Almer, et al. "Distribution of subcutaneous and intermuscular fatty tissue of the mid-thigh measured by MRI—A putative indicator of serum adiponectin level and individual factors of cardio-metabolic risk." PLOS ONE 16, no. 11 (2021): e0259952. http://dx.doi.org/10.1371/journal.pone.0259952.

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Obesity and metabolic syndrome (MetS) are associated with hypoadiponectinemia. On the contrary, studies revealed correlations between the amount of subcutaneous adipose tissue (SAT) and higher serum adiponectin levels. Furthermore, independent association of intermuscular adipose tissue (IMAT) deposit in the thigh with cardiometabolic risk factors (including total blood cholesterol, low-density lipoprotein (LDL), and triglycerides), and decreased insulin sensitivity, as MetS components, are sufficiently described. The combined relationship of thigh IMAT and SAT with serum adiponectin, leptin l

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Vitale, Jacopo Antonino, Carmelo Messina, Domenico Albano, et al. "Appendicular Muscle Mass, Thigh Intermuscular Fat Infiltration, and Risk of Fall in Postmenopausal Osteoporotic Elder Women." Gerontology 67, no. 4 (2021): 415–24. http://dx.doi.org/10.1159/000513597.

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<b><i>Background:</i></b> The association between the quantity and composition of skeletal muscle and the decline in physical function in elderly is poorly understood. Therefore, the primary aim of this cross-over study was to investigate the association between thigh intermuscular adipose tissue (IMAT) infiltration, appendicular muscle mass, and risk of fall in postmenopausal osteoporotic elder women. Second, we examined the differences in muscle mass, IMAT, and risk of fall in the same sample of older subjects after being classified as sarcopenic or nonsarcopenic on t

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Marcus, Robin L., Odessa Addison, Leland E. Dibble, K. Bo Foreman, Glen Morrell, and Paul LaStayo. "Intramuscular Adipose Tissue, Sarcopenia, and Mobility Function in Older Individuals." Journal of Aging Research 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/629637.

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Objective. Intramuscular adipose tissue (IMAT) and sarcopenia may adversely impact mobility function and physical activity. This study determined the association of locomotor muscle structure and function with mobility function in older adults.Method. 109 older adults with a variety of comorbid disease conditions were examined for thigh muscle composition via MRI, knee extensor strength via isometric dynamometry, and mobility function. The contribution of strength, quadriceps lean tissue, and IMAT to explaining the variability in mobility function was examined using multivariate linear regress

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Addison, Odessa, Robin L. Marcus, Paul C. LaStayo, and Alice S. Ryan. "Intermuscular Fat: A Review of the Consequences and Causes." International Journal of Endocrinology 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/309570.

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Muscle’s structural composition is an important factor underlying muscle strength and physical function in older adults. There is an increasing amount of research to support the clear disassociation between the loss of muscle lean tissue mass and strength with aging. This disassociation implies that factors in addition to lean muscle mass are responsible for the decreases in strength and function seen with aging. Intermuscular adipose tissue (IMAT) is a significant predictor of both muscle function and mobility function in older adults and across a wide variety of comorbid conditions such as s

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Rosano, Caterina, Anne Newman, Xiaonan Zhu, Adam Santanasto, Bret Goodpaster, and Iva Miljkovic. "INTERMUSCULAR ADIPOSITY: A NOVEL RISK FACTOR FOR COGNITIVE DECLINE IN A BIRACIAL COHORT OF OLDER ADULTS." Innovation in Aging 6, Supplement_1 (2022): 332. http://dx.doi.org/10.1093/geroni/igac059.1310.

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Abstract Skeletal muscle and brain health both decline with age. Poorer skeletal muscle characteristics may be early markers of cognitive decline. The Health ABC study obtained repeated measures of thigh intermuscular adiposity via CT (IMAT, Years 1 and 6) and Mini-Mental State Exam (MMSE, Years 1 through 10), in 1634 adults (69-79 years, 48% women, 35% black). Linear mixed effects models accounted for change (Years 1 and 6) in weight, muscle (strength, area), and adiposity characteristics (abdominal subcutaneous, visceral, total fat mass) and for dementia risk factors (education, APOE4, diabe

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Lescut, Nicolas, Etienne Martin, Philippe Maingon, et al. "Dependence of intrafraction prostate motion within the pelvis on fraction duration during whole pelvic intensity modulated arctherapy (IMAT) versus dynamic IMRT." Journal of Clinical Oncology 31, no. 6_suppl (2013): 190. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.190.

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190 Background: To compare the 3-dimensional intra-fraction variations of prostate position within the pelvis with whole-pelvic fixed-field intensity-modulated radiation therapy (IMRT) vs. intensity-modulated arc therapy (IMAT) in high-risk prostate cancer. Methods: Fifteen PCa patients underwent whole pelvic radiotherapy using either dynamic IMRT with a sliding window technique (n= 8) or IMAT (n= 7). All the patients had a kV cone-beam computed tomography (CBCT) before and immediately after each fraction of IMRT or IMAT. Intra-fraction motions of the prostate were determined using a 2-step pr

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Franco, Celina, Johannes D. Veldhuis, Ali Iranmanesh, et al. "Thigh intermuscular fat is inversely associated with spontaneous GH release in post-menopausal women with abdominal obesity." European Journal of Endocrinology 155, no. 2 (2006): 261–68. http://dx.doi.org/10.1530/eje.1.02211.

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Context: The metabolic syndrome is characterized by an increased accumulation of visceral adipose tissue (VAT) and blunted GH secretion. There are, however, no data on the association between GH secretion and other fat depots (in liver and muscle). Objective/design: The aim of this cross-sectional study, which included 20 post-menopausal women with abdominal obesity, was to determine the association between GH secretion and regional adipose tissue (AT) distribution. Twelve-hour GH profiles (2000–0800 h) were performed by blood sampling every 20 min. GH was analyzed using an ultra-sensitive ass

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Iori, Mauro, Elisabetta Cagni, Alan E. Nahum, and Giovanni Borasi. "IMAT-SIM: A new method for the clinical dosimetry of intensity-modulated arc therapy (IMAT)." Medical Physics 34, no. 7 (2007): 2759–73. http://dx.doi.org/10.1118/1.2739807.

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Schuler, John W., and Murray S. Korman. "Design and development of PC‐IMAT." Journal of the Acoustical Society of America 103, no. 5 (1998): 2988. http://dx.doi.org/10.1121/1.421689.

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Fjørtoft, K. E., and Tony Haugen. "Integrated Maritime Autonomous Transport Systems (IMAT)." Journal of Physics: Conference Series 1357 (October 2019): 012034. http://dx.doi.org/10.1088/1742-6596/1357/1/012034.

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Zur, Hadas, Eytan Ruppin, and Tomer Shlomi. "iMAT: an integrative metabolic analysis tool." Bioinformatics 26, no. 24 (2010): 3140–42. http://dx.doi.org/10.1093/bioinformatics/btq602.

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Kim, Jaehee, Stanley Heshka, Dympna Gallagher, et al. "Intermuscular adipose tissue-free skeletal muscle mass: estimation by dual-energy X-ray absorptiometry in adults." Journal of Applied Physiology 97, no. 2 (2004): 655–60. http://dx.doi.org/10.1152/japplphysiol.00260.2004.

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Skeletal muscle (SM) is a large and physiologically important compartment. Adipose tissue is found interspersed between and within SM groups and is referred to as intermuscular adipose tissue (IMAT). The study objective was to develop prediction models linking appendicular lean soft tissue (ALST) estimates by dual-energy X-ray absorptiometry (DXA) with whole body IMAT-free SM quantified by magnetic resonance imaging. ALST and total-body IMAT-free SM were evaluated in 270 healthy adults [body mass index (BMI) of <35 kg/m2]. The SM prediction models were then validated by the leave-one-out me

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Sheazadi, Lubna, Robert Appleyard, Natalie Foley, and Bernadette Foran. "A retrospective comparison of intensity-modulated arc therapy and 3-dimensional conformal approaches in the planning of grade 3 gliomas." Journal of Radiotherapy in Practice 17, no. 3 (2018): 266–73. http://dx.doi.org/10.1017/s1460396918000079.

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AbstractPurposeTo evaluate the extent to which intensity-modulated arc therapy (IMAT) for high-grade gliomas is comparable with three-dimensional conformal radiotherapy (3DCRT) in relation to the dose delivered to normal brain tissue (NBT), planning target volume (PTV) conformity and the dose delivered to brainstem and optic chiasma.MethodA total of 16 randomly selected 3DCRT treatment plans of grade 3 gliomas were re-planned using an IMAT planning technique and dose–volume histograms were compared. Primary outcomes were maximum, mean, 1/3 and 2/3 doses to NBT outside the PTV. Also the maximum

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Ge, Penglei, Huayu Yang, Jingfen Lu, et al. "Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage." Gastroenterology Research and Practice 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/5120760.

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Background. Currently there is no indicator that can evaluate actual liver lesion for early stages of viral hepatitis, nonalcoholic fatty liver disease (NAFLD), and cirrhosis. Aim of this study was to investigate if albumin binding function could better reflect liver function in these liver diseases.Methods. An observational study was performed on 193 patients with early NAFLD, viral hepatitis, and cirrhosis. Cirrhosis patients were separated according to Child-Pugh score into A, B, and C subgroup. Albumin metal ion binding capacity (Ischemia-modified albumin transformed, IMAT) and fatty acid

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Colin-Leitzinger, Christelle, Daniel Jeong, Mahmoud Abdalah, et al. "Abstract 5886: Pre-treatment adiposity measured by computed tomography and survival of women with high-grade serous ovarian cancer." Cancer Research 82, no. 12_Supplement (2022): 5886. http://dx.doi.org/10.1158/1538-7445.am2022-5886.

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Abstract The association of body mass index (BMI) with survival of women with ovarian cancer remains unclear due to mixed epidemiological evidence. This may be due, in part, to the fact that BMI is an imperfect measure of body fat as BMI does not distinguish weight from lean muscle versus adipose tissue. Here, we investigated the association of adiposity measured by computed tomography (CT) with survival among the most common histotype of ovarian cancer, high-grade serous ovarian cancer (HGSOC). The present study included 383 women diagnosed with HGSOC from 2008 to 2019 who were evaluated at H

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Hilton, Tiffany N., Lori J. Tuttle, Kathryn L. Bohnert, Michael J. Mueller, and David R. Sinacore. "Excessive Adipose Tissue Infiltration in Skeletal Muscle in Individuals With Obesity, Diabetes Mellitus, and Peripheral Neuropathy: Association With Performance and Function." Physical Therapy 88, no. 11 (2008): 1336–44. http://dx.doi.org/10.2522/ptj.20080079.

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Background and Purpose The primary purpose of this study was to report differences in calf intermuscular adipose tissue (IMAT), muscle strength (peak torque), power, and physical function in individuals with obesity, diabetes mellitus (DM), and peripheral neuropathy (PN) compared with those without these impairments. A secondary purpose was to assess the relationship between IMAT and muscle strength, power, and physical function. Subjects and Methods Six participants with obesity, DM, and PN (2 women, 4 men; mean age=58 years, SD=10; mean body mass index=36.3, SD=5; mean modified Physical Perf

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Hassler, Eva, Gunter Almer, Gernot Reishofer, et al. "Investigation of the Relationship between the Mid_Thigh Adipose Tissue Distribution Measured by MRI and Serum Osteocalcin—A Sex-Based Approach." Nutrients 14, no. 1 (2021): 112. http://dx.doi.org/10.3390/nu14010112.

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Osteocalcin, in its non-carboxylated form, has a positive effect on glucose metabolism. Additionally, osteocalcin levels are related to body composition, especially muscle mass. The relation to the distribution of different adipose tissue types, such as subcutaneous, intermuscular, and visceral adipose tissue, is unclear. This study aimed to investigate associations between serum osteocalcin and the distribution of subcutaneous and intermuscular adipose tissue of the mid-thigh. Furthermore, the influence of different training methods on osteocalcin levels was investigated. We performed adipose

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Acevedo-Fontanez, Adrianna, Caterina Rosano, Kristine Yaffe, et al. "ABDOMINAL MYOSTEATOSIS AND COGNITIVE FUNCTION: INSIGHTS FROM CARDIA STUDY." Innovation in Aging 8, Supplement_1 (2024): 245–46. https://doi.org/10.1093/geroni/igae098.0794.

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Abstract The role of myosteatosis in cognitive decline is largely from cross-sectional studies in White populations. Longitudinal studies including Black populations, who have a higher risk of both myosteatosis and dementia than Whites, are warranted. We tested the association between abdominal myosteatosis with 5-year change in cognition in 2,501 White and Black American men (n=1,078; 42% Black) and women (n=1,423; 49% Black) from the Coronary Artery Risk Development in Young Adults (CARDIA), and whether associations vary after adjustment for demographics, center, education, muscle area, foll

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Zhang, Ting, Jun Li, Xi Li, and Yanjun Liu. "Intermuscular adipose tissue in obesity and related disorders: cellular origins, biological characteristics and regulatory mechanisms." Frontiers in Endocrinology 14 (October 18, 2023). http://dx.doi.org/10.3389/fendo.2023.1280853.

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Intermuscular adipose tissue (IMAT) is a unique adipose depot interspersed between muscle fibers (myofibers) or muscle groups. Numerous studies have shown that IMAT is strongly associated with insulin resistance and muscular dysfunction in people with metabolic disease, such as obesity and type 2 diabetes. Moreover, IMAT aggravates obesity-related muscle metabolism disorders via secretory factors. Interestingly, researchers have discovered that intermuscular brown adipocytes in rodent models provide new hope for obesity treatment by acting on energy dissipation, which inspired researchers to e

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Bergia, Robert Emerson, Jung Eun Kim, and Wayne W. Campbell. "Differential Relationship Between Thigh and Calf Intramuscular Adipose Tissue Depots and Indices of Metabolic Health in Older Overweight and Obese Adults." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.904.4.

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IntroductionAccumulation of intramuscular adipose tissue (IMAT) is associated with insulin resistance, but there are limited data comparing the predictive ability of different IMAT stores with markers of metabolic health.PurposeThe purpose of this secondary analysis study was to investigate associations among thigh and calf IMAT stores and indices of metabolic health in older overweight and obese adults.MethodsSeventy‐three subjects (25 men, 48 women, age: 58 ± 11 y, BMI: 29.9 ± 4.9 kg/m2, mean ± SD) completed dietary interventions with (n=48) or without (n=25) energy restriction‐induced weigh

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Ertuglu, Lale A., Melis Sahinoz, Aseel Alsouqi, et al. "Intermuscular adipose tissue accumulation is associated with higher tissue sodium in healthy individuals." Physiological Reports 12, no. 13 (2024). http://dx.doi.org/10.14814/phy2.16127.

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AbstractBackground and AimsHigh tissue sodium accumulation and intermuscular adipose tissue (IMAT) are associated with aging, type 2 diabetes, and chronic kidney disease. In this study, we aim to investigate whether high lower‐extremity tissue sodium accumulation relates to IMAT quantity and whether systemic inflammatory mediators and adipocytokines contribute to such association.MethodsTissue sodium content and IMAT accumulation (percentage of IMAT area to muscle area) were measured in 83 healthy individuals using sodium imaging (23Na‐MRI) and proton (1H‐MRI) imaging of the calf. Insulin sens

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Bergia, Robert Emerson, Jung Eun Kim, and Wayne W. Campbell. "Differential Relationship between Thigh and Calf Intermuscular Adipose Tissue Depots and Muscle Compartments with Indices of Cardio‐metabolic Health." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.794.14.

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IntroductionAccumulation of intermuscular adipose tissue (IMAT) is positively associated with insulin resistance, but there are limited data comparing the predictive ability of different IMAT stores to influence markers of cardio‐metabolic health. Investigation into the potential of IMAT to preferentially infiltrate muscle compartments with disparate muscle fiber type predominance is warranted.PurposeThe purpose of this secondary analysis study was to investigate associations among thigh and calf IMAT stores and indices of cardio‐metabolic health in adults who are overweight and obese. A subse

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Jing, Xiaofan, Lingling Tan, Hongbo Fu, Ling Yang, and Ming Yang. "Associations of ADL Disability With Trunk Muscle Mass and Muscle Quality Indicators Measured by Opportunistic Chest Computed Tomography Imaging Among Older Inpatients." Frontiers in Medicine 8 (October 28, 2021). http://dx.doi.org/10.3389/fmed.2021.743698.

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Objectives: Sarcopenia is an important predictor of dependence in activities of daily living (ADL disability); however, the association between muscle quality and ADL disability has not been established. We aimed (1) to assess the feasibility of measuring trunk muscle mass and muscle quality by chest CT images; and (2) to explore the possible associations of ADL disability with these muscle mass and muscle quality indicators among older inpatients.Methods: We included older patients in an acute care ward. ADL disability was defined as the Barthel Index (BI) score ≤ 60 points. Unenhanced chest

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Dilaver, R. Gulsah, Mert Demirci, Rachelle Crescenzi, et al. "Intermuscular adipose tissue and muscle function in patients on maintenance hemodialysis." Physiological Reports 13, no. 13 (2025). https://doi.org/10.14814/phy2.70363.

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AbstractSarcopenia is common in advanced chronic kidney disease (CKD), contributing to poor outcomes. Intermuscular adipose tissue (IMAT) may worsen muscle function through metabolic and inflammatory pathways. We conducted a cross‐sectional study comparing maintenance hemodialysis (MHD) patients and controls to assess IMAT and its associations. IMAT was measured via calf muscle MRI, and body composition (BMI, fat mass index), metabolic markers (hs‐CRP, TNF‐α, IL‐6, insulin resistance), and circulating cell‐free mitochondrial DNA (ccf‐mtDNA) were assessed. Muscle function was evaluated with han

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palzkill, victoria, Divyansha Moparthy, Daniel Kopinke, and Terence Ryan. "Abstract Tu0080: Suppression of Intramuscular Adipose Tissue Improves Limb Outcomes in Mice with Hindlimb Ischemia." Arteriosclerosis, Thrombosis, and Vascular Biology 45, Suppl_1 (2025). https://doi.org/10.1161/atv.45.suppl_1.tu0080.

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Background: Chronic limb threatening ischemia (CLTI) is the most severe form of the atherosclerotic disease peripheral arterial disease (PAD). Surgical revascularization and endovascular therapies are the primary interventions for CLTI which improve macrovascular blood flow, however limb muscle function is often still impaired following these procedures suggesting CLTI involves pathological changes to non-vascular cell types. The replacement of skeletal muscle with intramuscular adipose tissue (IMAT) is prominent among patients with CLTI and is likely formed by differentiation of fibro-adipoge

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