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Sun, Zimin, Huilan Liu, Yue Wu, Changcheng Zheng, Baolin Tang, Xiaoyu Zhu, and Qifa Liu. "Intensified Myeloablative Conditioning Regimen without Antithymocytic (ATG) Results in Superior Patient Outcome Compared to Myeloablative Conditioning Regimen for Single-Unit Umbilical Cord Blood Transplantation in Hematological Malignancies." Blood 128, no. 22 (December 2, 2016): 5837. http://dx.doi.org/10.1182/blood.v128.22.5837.5837.
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Abstract The superiority and safety of strengthening conditioning regimen for single- unit unrelated cord blood transplantation (sUCBT) in hematological malignancies remain controversial. We retrospectively analyzed the clinical data of 251 hematological malignancies undergoing sUCBT from Apr 2000 to Dec 2014 at Department of hematology in Anhui Provincial Hospital. Out of the 251 patients, 216 received the intensified myeloablative conditioning regimen (IMCR), and 35 received the myeloablative conditioning regimen (MCR). We evaluated the effect of IMCR without using Antithymocyte globulin (ATG) on patient outcomes. The cumulative incidence of myeloid and platelet engraftment of the IMCR group was significantly higher than that in the MCR group (96.98% vs. 82.81%, 85.89% vs. 51.79%, P=0.000 and 0.003, respectively). Corresponding incidences of transplantation-related mortality (TRM) by 180 days in the IMCR group and the MCR group were 19.50% vs. 41.67% (P=0.003), respectively. There were no differences in the incidence of grade II to IV acute GVHD (aGVDH), grade III to IV aGVHD and 2-year cumulative incidence of relapse. Up to Dec. 2015, with a median follow-up of 30 months, the estimated 3-year overall survival and disease- free survival in the IMCR group were both significantly higher than that of the MCR group (64.8% vs. 35.5%, 61.6% vs. 35.5%, P=0.000 and 0.001, respectively). This study is the first to show the superiority of intensified myeloablative regimen to conventional myeloablative regimen.A large-scale prospective study was needed. (A) (B) Figure 1 The cumulative incidence of neutrophil and platelet engraftment of the IMCR group and MCR group. (A)The cumulative incidence of neutrophil engraftment of the IMCR group was predominantly higher than that in the MCR group(96.98% vs. 82.81%, P=0.000). (B)The cumulative incidence of platelet engraftment of the IMCR group was also higher than that in the MCR group(85.89% vs. 51.79%, P=0.003). Figure 1. The cumulative incidence of neutrophil and platelet engraftment of the IMCR group and MCR group. (A)The cumulative incidence of neutrophil engraftment of the IMCR group was predominantly higher than that in the MCR group(96.98% vs. 82.81%, P=0.000). (B)The cumulative incidence of platelet engraftment of the IMCR group was also higher than that in the MCR group(85.89% vs. 51.79%, P=0.003). Figure 2 Comparison of the incidence of 3-year OS between the IMCR group and the MCR group.The incidence of 3-year OS of the IMCR group is predominantly higher than that of the MCR group(62.4% vs. 35.5%,P=0.001). Figure 2. Comparison of the incidence of 3-year OS between the IMCR group and the MCR group.The incidence of 3-year OS of the IMCR group is predominantly higher than that of the MCR group(62.4% vs. 35.5%,P=0.001). Figure 3 Figure 3. Disclosures No relevant conflicts of interest to declare.
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Ssatar, Ibdal, Mohd Nur Ikhmal Salehmin, Mimi Hani Abu Bakar, Wan Ramli Wan Daud, Ika Dyah Kumalasari, Muhammad Aziz, Mahendara Rao Somalu, and Byung Hong Kim. "Evaluating hydrogen production from glucose using graphite felt beads as a solid matrix in immobilized mixed cell reactor at thermophilic fermentation." Communications in Science and Technology 8, no. 2 (December 31, 2023): 180–89. http://dx.doi.org/10.21924/cst.8.2.2023.1238.
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This study has successfully evaluated graphite felt (GF) beads as a solid matrix to immobilize or trap the mixed cultures in an immobilized mixed-cell reactor (IMcR). The anaerobic sludge of palm oil mill effluent was used as an inoculum source in the IMcR with mixed culture. Here, glucose, sucrose, and starch were used as the model substrates to evaluate the performance of IMcR with GF beads for producing bio-hydrogen (BioH2). BioH2, effluent, and surface morphology of GF beads were analyzed by using gas chromatography equipped with a thermal conductivity detector, high-performance liquid chromatography, and scanning electron microscopy, respectively. The highest H2 yield (YH2) and production rates were obtained at 304.0 ± 13.2 mL g?1COD (corresponding to 2.26 mol mol?1glucose) and 1403 ± 61 mL L?1 day?1, respectively. IMcR with GF beads is a new approach for generating high YH2, which can be used for more than two months in an experimental run.
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Ramírez-López, Sandra C., Manuel Alejandro Rentería-Gómez, Cesar R. Solorio Alvarado, and Rocío Gámez-Montaño. "Synthesis of Peptidomimetics via IMCR/Post-Transformation Strategy." Chemistry Proceedings 3, no. 1 (November 14, 2020): 4. http://dx.doi.org/10.3390/ecsoc-24-08396.
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A series of three 2,5-Diketopiperazine (DKPs) were synthesized via one-pot process through the post- isocyanide-based multicomponent reactions (IMCR)-transformation strategy. This strategy emphasizes the role of orthogonal bifunctional reagents in the IMCR process to increase their synthetic potential, allowing us accessing a synthetic platform from which it is possible to obtain privileged heterocyclic peptidomimetics via lactamization reaction.
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Koopmanschap, Gijs, Eelco Ruijter, and Romano VA Orru. "Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics." Beilstein Journal of Organic Chemistry 10 (March 4, 2014): 544–98. http://dx.doi.org/10.3762/bjoc.10.50.
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In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues. In particular, the incorporation of cyclic constructs into peptides is of high interest as they reduce the flexibility of the peptide enhancing often affinity for a certain receptor. Moreover, these cyclic mimics force the molecule into a well-defined secondary structure. Constraint structural and conformational features are often found in biological active peptides. For the synthesis of cyclic constrained peptidomimetics usually a sequence of multiple reactions has been applied, which makes it difficult to easily introduce structural diversity necessary for fine tuning the biological activity. A promising approach to tackle this problem is the use of multicomponent reactions (MCRs), because they can introduce both structural diversity and molecular complexity in only one step. Among the MCRs, the isocyanide-based multicomponent reactions (IMCRs) are most relevant for the synthesis of peptidomimetics because they provide peptide-like products. However, these IMCRs usually give linear products and in order to obtain cyclic constrained peptidomimetics, the acyclic products have to be cyclized via additional cyclization strategies. This is possible via incorporation of bifunctional substrates into the initial IMCR. Examples of such bifunctional groups are N-protected amino acids, convertible isocyanides or MCR-components that bear an additional alkene, alkyne or azide moiety and can be cyclized via either a deprotection–cyclization strategy, a ring-closing metathesis, a 1,3-dipolar cycloaddition or even via a sequence of multiple multicomponent reactions. The sequential IMCR-cyclization reactions can afford small cyclic peptide mimics (ranging from four- to seven-membered rings), medium-sized cyclic constructs or peptidic macrocycles (>12 membered rings). This review describes the developments since 2002 of IMCRs-cyclization strategies towards a wide variety of small cyclic mimics, medium sized cyclic constructs and macrocyclic peptidomimetics.
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Mota Palma, Jaqueline, Norma Ivonne González-Arratia López-Fuentes, José Luis Valdez Medina, Sergio González Escobar, and Gabriela Hernández Vergara. "Construcción y Análisis Estadístico del Inventario Multidimensional de Celos Románticos: Estudio Preliminar." Actualidades en Psicología 30, no. 120 (June 27, 2016): 31. http://dx.doi.org/10.15517/ap.v30i120.18977.
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<div class="page" title="Page 1"><div class="section"><div class="layoutArea"><div class="column"><p>Con el objetivo de construir y validar una prueba para medir propiedades de los celos románticos, se desarrolló el Inventario Multidimensional de Celos Románticos (IMCR) desde tres ejes: 1) su conceptualización, 2) circunstancias que lo generan y 3) respuestas cognitivas, afectivas y conductuales involucradas. El IMCR está constituido por cinco escalas tipo Likert con sus respectivas opciones de respuesta. Se acudió a juicio de expertos para la validez de contenido y por análisis factoriales exploratorios para la validez de constructo de cada escala, presentando coeficientes de confiabilidad superiores a (α > .873). Por esto, el IMCR tiene una estructura relativamente clara con dimensiones en parte independientes y que miden con razonable precisión los tres ejes; concluyendo que los celos románticos son un constructo multidimensional con respuestas afectivas, cognitivas y conductuales desencadenadas a partir de una situación que representa la posible pérdida de la pareja.</p></div></div></div></div>
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Archilla, Ivan, Leire Pedrosa, Marta Garcia de Herreros, Laia Fernandez-Mañas, Francis Esposito, Pedro Jares, Carolina Figueras, et al. "An Immune-metabolic signature (IMMETCOLS) identifies three clusters in mCRC with different immune-phenotype distribution and potential clinical implications." Journal of Clinical Oncology 40, no. 16_suppl (June 1, 2022): e15534-e15534. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e15534.
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e15534 Background: The overall response rate following immune check-point blockade (ICB) is < 5% in microsatellite stable (MSS) advanced colorectal cancer (mCRC), and between 30-35% in MSI mCRC. We here evaluate the relationship between our immune-metabolic signature (IMMETCOLS) distribution (cluster (IMC) 1; mesenchymal glycolytic, IMC 2; epithelial-non glycolytic and IMC 3; epithelial mitochondrial oxidative) with immune phenotypes (inflamed (IF), immune-excluded (IE) and immune-desert (ID)) in MSS and MSI mCRC patients (pts). Methods: We have analyzed IMMETCOLS in a retrospective cohort of 128 mCRC pts enriched with MSI-H and BRAF genotype using the nCounter platform (Nanostring Technologies, US). Immune phenotypes were evaluated by immunohistochemistry using 7 immune markers (CD68, CD163, CD8, CD3, FOXP3, PD-L1 and PD1) in a subset of 47 mCRC pts (27 MSS and 20 MSI), in TMAs containing 4 cores from the center of the tumor (CT) and invasive front (IF). The number of stained immune cells was counted using a computerized image analysis system, and PD-L1 was evaluated using CPS score (< 1 vs > 1). Patients having a CD3 cell count below 572 cells/mm2 and a CD8 density below 175 cells/mm2 in IF or CT were considered as ID. (Halama Nils, 2011). CD3 density was also semi-quantitatively estimated in peritumoral stroma and intra-tumoral (range 1-4), defining as IE those cases with a difference > 1 between the two regions in both IF and CT (Brooks JM, 2019). Results: Cluster distribution was similar between MSI (IMC1-40%, IMC2-20% and IMC-40%) and MSS (IMC1-34%, IMC2-24%, IMC3-43%) pts. Patients with high LDH levels (> 1.5ULN) were enriched with IMC3 phenotype (p < 0.0001). MSI have increased CD3 (p = 0.002), CD68 (p = 0.002) and CD163 (p = 0.001) in CT than MSS patients. IMC1 pts had increased CD163/CD68 ratio in CT (p = 0.004). 75% of MSI pts were IE and 25% IF. 55% of MSS pts were IE, 38% ID and 7% IF. IMMETCOLS/ immune-phenotype distribution was: IMC1 (16% ID/ 84% IE), IMC2 (12% ID/ 63% IE/ 25% IF) and IMC3 (35%ID/ 47% IE/ 18% IF). PD1 immuno-expression > 1% (IF and CT) and PD-L1 positivity was observed in 38%, 30% and 28% of pts respectively. There were no differences in PD-L1 (CPS) and PD1 expression between MSS and MSI tumors. Inflamed tumors show higher PD-L1 expression compared with IE and ID immune-phenotypes (p = 0.014). PD1 > 1% expression at IF was significatively lower in IMC1 vs IMC2 and IMC3 tumors (p = 0.032). Conclusions: IMC1 subtype is associated with low PD1 expression, high CD163/CD68 ratio and IE phenotype even in MSI-H mCRC patients. Therefore, IMMETCOLS testing would be of value to identify MSI mCRC pts that do not benefit to ICB therapy.
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Torres-Hernández, Fernando, Ángel Rentería-Gómez, and Rocío Gámez-Montaño. "Synthesis of Epoxyisoindolinones via Microwave-Assisted Ugi-4CR/Intramolecular-Diels-Alder Reaction." Cells 3, no. 1 (November 14, 2020): 83. http://dx.doi.org/10.3390/ecsoc-24-08425.
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A series of epoxyisoindolinones were synthesized by microwave-assisted post-IMCR transformation-based domino strategy via the Ugi-4CR/Intramolecular-Diels-Alder (U-4CR/IMDA) sequence under mild, solvent-, catalyst-free ecofriendly conditions, and orthogonal-bifunctional components. Epoxyisoindolinones are a privileged core of high interest in medicinal chemistry mainly for its anticancer activity in several cell lines.
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Ramírez-López, Sandra C., Àngel Rentería-Gómez, Luis E. Cárdenas Galindo, and Rocío Gámez-Montaño. "Synthesis of Tetrakis-Tetrazole via a Repetitive MCR." Chemistry Proceedings 3, no. 1 (November 14, 2020): 44. http://dx.doi.org/10.3390/ecsoc-24-08395.
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The synthesis of novel and complex molecules of tetrakis-tetrazole was done via a Ugi-azide repetitive reaction from easily accessible starting materials in good yields. The use of orthogonal bifunctional reagents in isocyanide-based multicomponent reactions (IMCR) allowed the synthesis of structurally complex molecules in one pot manner. The molecules herein synthesized could have applications such as use as chelating agents and organocatalysts.
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Rentería-Gómez, Manuel A., Tannya R. Ibarra-Rivera, and Rocío Gámez-Montaño. "A One-Pot Synthesis of Fluoro α-Acylamino Amide-Xanthates via an IMCR-Post Transformation Strategy." Chemistry Proceedings 3, no. 1 (November 14, 2020): 59. http://dx.doi.org/10.3390/ecsoc-24-08421.
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A series of six novel amide-xanthate products containing several fluorine atoms were prepared in moderate to good yields (40–92%) via an isocyanide-based multicomponent reaction (IMCR) of 5-CR by Ugi-4CR followed by an SN2 sequence in a one-pot manner. The design of molecules with fluorine atoms is of interest in medicinal chemistry and a research line of our interest. The role of fluorine atoms in biological properties is well documented, improving bioavailability, lipophilicity, and metabolic resistance in bioactive molecules.
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Ramírez-López, Sandra C., M. V. Basavanag Unnamatla, and Rocío Gámez-Montaño. "A One-Pot Process for the Synthesis of Alkyne-3-tretrazolyl-tetrazolo [1,5-a] Quinolines." Proceedings 9, no. 1 (November 14, 2018): 42. http://dx.doi.org/10.3390/ecsoc-22-05798.
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An efficient synthesis of alkyne-3-tetrazolyl-tetrazolo[1,5-a] quinolones via a one-pot isocyanide-based multicomponent reaction (IMCR) process: I-MCR Ugi-azide/SNAr/ring-chain azido tautomerization was performed under eco-friendly conditions. We report the one-pot synthesis of tris-heterocycles containing a tetrazolo[1,5-a] quinoline connected to a 1,5-disubstituted-tetrazole (1,5-DS-T). The synthesis of these compounds is of great interest in synthetic and medicinal chemistry because these heterocycles are considered privileged scaffolds and their preparation and evaluation may lead to the discovery of novel bioactive molecules.
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Lakhotia, Subhash Chandra. "What we expect of integrative medicine case reports?" Integrative Medicine Case Reports 1, no. 1 (2020): 1. http://dx.doi.org/10.38205/imcr.010101.
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In recent times, launching of new research Journals has become common and also worrisome. Increasing demands and specializations require new research Journals. Thus while new Journals are welcome, the worry stems from the fact that a majority of the newly launched Journals have unscrupulous commercial interests rather than their being interested in sharing of good new knowledge between peers. Thus we need to ask why is this new Journal required and what we expect from it? When Prof. Akshay Anand, the Editor-in-Chief of this Journal asked me to write an editorial for the first issue, I was a little surprised. I am not trained in Ayurveda, Unani or any of the other traditional or modern healthcare system. The only connection that I have with these alternative medical systems is that one of my research areas relates to basic research in Ayurvedic Biology using the Drosophila model. My other qualification for writing this editorial can be my long-term conviction that Indian academia need to publish good research Journals and that our researchers should take pride in publishing in such Journals also.
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Price, Amy, Rakesh Biswas, and Akshay Anand. "Person-centered healthcare and integrated public health." Integrative Medicine Case Reports 1, no. 1 (2020): 3. http://dx.doi.org/10.38205/imcr.010103.
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The public brings to the table valuable perspectives learned from living with the health problems research works to solve. Patients as research partners in the clinic, at home, and in the lab can provide the fine details for a successful implementation that differentiate a research finding that sits expensive and unused from primary care that improves quality of life. Life experiences can reveal practical wisdom for prioritizing the health questions that matter to patients . It is possible that contributions by patient research partners may go unreported, and this can be compounded by role confusion where the terms “public involvement”, “community engagement”, “citizen support”, and “quantified self-groups” are used interchangeably . We know from a multiplicity of research that priorities recorded by researchers on behalf of patients may not be the same as those that are important to patients.
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Poojari, Spoorthi, Babita Ghai, Kashinath Metri, Sheetal Jindal Gupta, and Prashant Verma. "Chronic low back pain: Can Yoga as an integrative approach be the best way forward?" Integrative Medicine Case Reports 1, no. 1 (2020): 6. http://dx.doi.org/10.38205/imcr.010106.
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Chronic Low Back pain (CLBP) is common public health problem, and globally one of the leading cause of disability. Several research studies advocate Yoga may add on as an effective therapy for CLBP patients. The present case study is an attempt to elucidate the outcome of Integrated Approach of Yoga Therapy (IAYT) intervention (which included loosening practices, asanas with breathing, relaxation, pranayama and meditation techniques) as an adjunct and integrative therapy to reduce pain symptoms, pain-associated disability and their overall quality of life in CLBP adult patients. The manuscript illustrates the two CLBP patients, refractory to conservative management, visiting pain clinic at Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Both the patients received a series of 60 minutes IAYT class conducted for a span of 15 days along with the institutional usual care regime as their treatment protocol. Patients were evaluated at baseline, 1 month and 3 month using various assessment tools (for pain intensity, disability, neuropathic pain component, quality of life, pain experiences, mental health, fear of movements and overall clinical benefit). Both the patients showed steady and gradual progression in reducing their pain intensity and its associated disability, quality of life and mental health. The patients narrated their experience and their ability to manage bio-psycho-socio aspects associated with CLBP. They attributed their positive changes to IAYT protocol.
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Gandhi, Ajay, Lakhveer Singh, and Mayank Pandey. "Impact of neurotherapy treatment on knee pain." Integrative Medicine Case Reports 1, no. 1 (2020): 11. http://dx.doi.org/10.38205/imcr.010111.
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Neurotherapy is an alternative way of healing. It deals with whole body mind system. Our present study is based on the impact of Neurotherapy in pain relief in a patient who was suffering from knee Pain. Patient came to the Neurotherapy Centre Mohali for the treatment of knee pain. Patient informed us that she was already taking medications and physiotherapy for her pain, but it was incurable since a long period of time. She was self-directed to take the Neurotherapy treatment. After 82 sittings, she experienced a positive effect on pain and she felt better after taking Neurotherapy treatment.
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Satyam, Tripathi, Shenoy Kiran, and Munamarty Bhavani. "Effect of Integrated Ayurveda and Yoga Therapy (IAYT) on remission management of non-Hodgkin lymphoma: A single case study." Integrative Medicine Case Reports 1, no. 1 (2020): 13. http://dx.doi.org/10.38205/imcr.010113.
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Non-Hodgkin lymphomas are lymphoid malignant neoplasms and the prognosis depends on the staging and response to therapy. Stress is an independent factor which can affect the prognosis of the disease. The purpose of the current case study was to evaluate the impact of Yoga and Ayurveda as complementary therapy on the prognosis of the disease and the effect of the same on perceived stress level. A 36 year patient diagnosed with relapsed Non-Hodgkin Lymphoma (NHL) after receiving 3 rounds of chemotherapy and bone marrow transplant visited Union Yoga Ayurveda Clinic in Singapore for therapy. Perceived stress, complete blood count and hemoglobin were assessed pre and post intervention. A 6 month follow up was also done with similar evaluations. The patient was given holistic Yoga therapy and Ayurveda herbal treatment including patrapindasweda (herbal compress) and pichu(herbal soaked gauze pieces). The patient reported improvement in day to day energy levels and immunity with increase in WBC count. The perceived stress scores also showed distinct improvement post intervention. The current case study suggests that the integrative yoga and Ayurveda therapy was feasible and showed improvement in stress and complete blood count in patients with Non-Hodgkin lymphomas.
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Kumar, Saurabh, Richa Shri, Sushmita Kaushik, Varinder Singh, and Akshay Anand. "Electrophysiological assessment of retinal functions by ERG in Ischemia/Reperfusion (I/R) Allium cepa pre-treated mice." Integrative Medicine Case Reports 1, no. 1 (2020): 18. http://dx.doi.org/10.38205/imcr.010118.
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Retinal disorders are the one of the most challenging and complex degenerative diseases that need to be addressed because of rapid increase in the number of affected individuals. Most of the available treatments strategies are inadequate to exert permanent solution to the patients. Therefore, as an alternative approach we wanted to test the efficacy of Allium cepa(A. cepa) in an Ischemia/Reperfusion (I/R) mouse model. We orally administered the aqueous extract of A. cepa at different dosages 100 mg/kg, 200 mg/kg, 300 mg/kg 24 hrs prior to the surgery. Electroretinogram (ERG) analysis was carried out at 7 day, 21 day, and 28 day after the surgery. ERG recording depicted that A. cepa administration is able to increase the implicit time but not at the statistically significant level for which larger sample size and deeper analysis is required.
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Kaur, Navneet, Neeru Malik, Pooja Sharma, and Akshay Anand. "Yoga: a tool for amelioration of obesity." Integrative Medicine Case Reports 1, no. 1 (2020): 29. http://dx.doi.org/10.38205/imcr.010129.
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In this study the case of overweight/obese participant is presented. The participant is a resident of Panjab University, Chandigarh, India. She voluntarily enrolled herself in the Yoga camp which was conducted at Gymnasium Hall, Panjab University, Chandigarh. The patient performed the Diabetic Yoga protocol for one month. The weight of the patient before joining the Yoga camp was 96 kg and the height was 170 cm. During the conversation, the patient revealed that during the practice of one month Diabetic Yoga protocol she lost 6 kg of her weight. This case report is an attempt to provide Yoga as safe, economical and simple technique for weight reduction.
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Singh, Ravinder. "Widening horizons: Adding quality." Integrative Medicine Case Reports 1, no. 1 (2020): 32. http://dx.doi.org/10.38205/imcr.010132.
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Background: Ageing is inevitable and unavoidable. It brings various challenges with it. An aged person faces physical, mental and social problems. India crossed the mark of 7% aged population above 60 years, putting in the club of few countries which have such a big proportion of population in this age group. Various specialities were created based on gender or age group. Geriatric Medicine and Gerontology were the specialties, which laid down the foundation of health and medical care in the elderly. Various approaches were developed to take care of health of the older persons. Summary: With the advent of technology and newer medical interventions, focus increased on various narrow domains of human body. Obviously, mental health became an important area of care, as numbers of older persons are increasing and their mental health domains are affected due to physical, physiological, pathological and social factors. Multi-pronged approach is required to manage mental health in older persons. The landscaping of pharmacological, immunological and technological interventions changed with time. Newer policies were developed and infra-structure created. India also saw paradigm shift in vision for the care of its older populations. Key message: The psychological research facilities were created in few of the universities and colleges. Biological or molecular interventions were next areas of focus. Next came the specialties of Geriatric Medicine and Geriatric Mental Health or Gero-Psychiatry. Many medical colleges started courses in Geriatric Medicine. From 2005 geriatric mental health became major area of action. Many more medical colleges and NIMHANS followed this trend and created Gero-Psychiatric or Geriatric mental Health facilities. Quite a large number of technologies have been identified and developed for older persons to support their mental health. Present paper looks into the various technologies, which may be very helpful in helping older persons to lead healthier and active lives.
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Nadholta, Pooja. "Efficacy of Yoga on pregnancy outcome, J Altern Complement Med. 2005 Apr;11(2):237-44." Integrative Medicine Case Reports 1, no. 1 (2020): 37. http://dx.doi.org/10.38205/imcr.010137.
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Pregnancy is a unique and challenging state, both physically and mentally. This requires mental, physical and social adaptation. Pregnancy related complications like pregnancy induced hypertension, preeclampsia, physiological and psychological stress, impaired placentation directly affect the fetal growth and also health of the neonate. It is already shown by animal experimentation that pregnancy outcomes are directly affected by prenatal maternal stress and it results in early programming of various organ systems that permanently changes neuroendocrine regulation and behavior in offspring. Various life events, illness, divorce, financial and social problems are some of the common stressor during pregnancy that activates hypothalamus-pituitary-adrenal cortex system (HPA axis) and sympathetic nervous system-adrenal medulla system (stress regulation system). Physical alteration, hormonal changes and anxiety are common during pregnancy period and these worsen the stress response. Already various attempts have been made to reduce pregnancy related stress. A study demonstrated that Yoga can be an effective therapy in reducing the pregnancy related complications and improving fetal outcomes. Satyapriya et al.showed that Yoga reduces anxiety, depression and pregnancy related uncomfortable experiences . Meditations inhibit the HPA axis that is activated during stress and calms the mind. Yoga is used to promote positive health and it uses holistic approach to reduce the stress. Integrated approach of Yoga therapy (IAYT) helps in reducing stress by practicing different postures (asanas), slow controlled breathing (Pranayama), Meditation and Chanting. This study tests the effect of IAYT on pregnancy related complications, stress and pregnancy outcome.
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Jogdand, Reshma P., Amit Singh, and Raghuram Nagratna. "Integrated approach of yoga therapy towards morbid obesity: A case report." Integrative Medicine Case Reports 1, no. 1 (2020): 39. http://dx.doi.org/10.38205/imcr.010139.
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The present case study is of evaluation of Grade 3 obesity who visited the Arogyadhama (SVYASA University, Bangalore). Conversations with the patient uncovered that the patient was being treated for obesity and patient portrayed his capacity to deal with the mental pressure related with overweight. He credited it to the inspirational demeanor created by his Yoga practice for 48 days. The patient was additionally ready to decrease body weight. The present narrative is an endeavor to give IAYT Practices, detoxification through Naturopathy.
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Singh, Ravinder. "Does India need ministry of public health? – Lessons learnt from COVID-19 and road ahead." Integrative Medicine Case Reports 1, no. 2 (2020): 1. http://dx.doi.org/10.38205/imcr.010201.
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World over there has been debates on the current emergency of COVID-19 and where we failed? Comparing the Spanish Flu 1918 (1) and the COVID-19, it is clear that the prevention strategies like social distancing, hand washing, and mask use, remains only hope for fast-spreading emergencies or disasters like COVID-19 (2). As compared to Spanish Flu-1918, population density is more now and people move across the globe much faster due to the vast network of air travel, posing greater risk to exposed populations. Even today, the challenge remains the lack of vaccines, shortage of appropriate equipment, and healthcare manpower. The basic role of the World Health Organisation and Alma Ata Declaration 1978 was strengthening primary and preventive care by the year 2000 (3). However, the world supported technology to the extent that now we are left with the only option to lockdown city after city across more than 200 counties.
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Deshpande, SN, and VL Nimgaonkar. "Turning gold into platinum: a supplement to guest editorial on “Ministry of Public Health”." Integrative Medicine Case Reports 1, no. 2 (2020): 4. http://dx.doi.org/10.38205/imcr.010204.
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Dr. Ravinder Singh indeed articulated an urgent need for a new, robust Indian public health law based on principles of prevention and promotion by empowering communities. He avers that the current framework of laws is inadequate to deal with new and emerging healthcare emergencies and indeed, even basic healthcare needs. He calls for a comprehensive public health law. He proposes that a new Ministry be formed by integrating modern principles of public health with the ancient Indian indigenous systems of medicine which are currently housed under the AYUSH ministry, which will be the implementation agency for this law. This change, he states, will include expanding the basic medical degree to combine all aspects of medical health, encompassing social, spiritual, mental and medical components of healthcare system (integration at ministry level and college level).
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Brownstein, Arthur. "Reflections on life-a personal account of interaction with HH Dalai Lama." Integrative Medicine Case Reports 1, no. 2 (2020): 6. http://dx.doi.org/10.38205/imcr.010206.
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His Holiness Dalai Lama has given me more than I could ever ask for in this life. I met Dalai Lama in Bangalore, in 1989, at the 1st International Holistic Health and Medicine Conference. There were about a thousand international delegates in attendance for the two-day event.At the conference, before he began his talk, he walked down the aisles of all the rows of delegates where we were seated. We all stood in respect of his presence as he walked by.
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Kaur, Navneet, Neeru Malik, Deepali Mathur, Surinder Pal, Rakesh Malik, and Sumit Rana. "Mindfulness and yoga halt the conversion of pre-diabetic rural women into diabetics-a pilot study." Integrative Medicine Case Reports 1, no. 2 (2020): 7. http://dx.doi.org/10.38205/imcr.010207.
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Background and Purpose: A plethora of studies have been conducted in the past, which have proven the salutary effects of yoga practice. Yoga and other mind body techniques are deemed as stress relievers and have shown therapeutic effectiveness in preventing the development and progression of several lifestyle diseases including Diabetes. Yoga practice may help in managing Diabetes by regulating the glucose levels in blood. In this study we have evaluated the efficacy of three months of AYUSH-approved Diabetic Yoga Protocol (DYP) on high-risk individuals.
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Metri, Kashinath G., Seema Rathi, Jalandhara , Amit Singh, and Nagaratna R. "Conservative and non-surgical management of lumbar disc herniation." Integrative Medicine Case Reports 1, no. 2 (2020): 15. http://dx.doi.org/10.38205/imcr.010215.
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A case of a 16-year-old Indian adolescent with discal herniation in L4 – L5 region with classical sign of ‘foot drop’ was successfully managed by conservative, non-surgical approach following principles of yoga intervention. Patients practised yoga under supervision of yoga expert, four times a day for first two weeks followed by once a day for consecutive two years. Yoga protocol included gentle yoga based loosening practices, simple asanas, yogic breathing techniques and yogic guided relaxation, pranayama and meditation. One year and two-year follow-ups showed complete revival of normal function and healing of the affected spinal cord disorder. A case which was recommended for surgery recovered with yoga intervention.
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Basu, Nilanjana. "Homoeopathic treatment leading to a unique response in a patient with renal cell carcinoma." Integrative Medicine Case Reports 1, no. 2 (2020): 19. http://dx.doi.org/10.38205/imcr.010219.
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A 45-year-old male patient presented with bilateral solid renal mass probably renal cell carcinoma (RCC). After initial treatment, the patient got symptomatic relief from pain in flanks, acute retention of urine and hematuria. The patient initially declined repeated investigations but agreed for an ultrasound after two years of treatment; the result showed reduction in size of the mass. The urea, creatinine and hemoglobin percentage were normal and reported a normal blood pressure. The quality of life was maintained without the conventional surgery, radiotherapy, chemotherapy, or immunotherapy. While this case provides evidence of positive outcomes for homeopathic therapy, more studies are required in a hospital setting to establish the real extent to which this therapy may be employed.
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Tripathi, Satyam, Megha Panchal, and Nooraini Binti Aliyas. "Effect of Integrated Ayurveda and Yoga Therapy (IAYT) on osteoporosis detected in breast cancer patient on remission- A single case study." Integrative Medicine Case Reports 1, no. 2 (2020): 23. http://dx.doi.org/10.38205/imcr.010223.
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This is a case study for invasive ductal carcinoma diagnosed in a patient aged 60 years in 2015. She went through chemotherapy and radiotherapy and was on remission in 2016. Bone density degeneration was the side effect from the breast cancer treatment. After trying the conventional treatment, she was not satisfied, she came to Union Yoga Ayurveda (UYA), Singapore. She came to clinic looking for alternative therapy to help her increase her bone density, cope up with weakness and overall mental and physical wellbeing. The patient was given holistic treatment of yoga and Ayurveda, involving patra pinda sweda (herbal compress) and picchu (herbal soaked gauze pieces). The yoga therapy involved asanas practise to increase strength, breathing and meditation for overall wellbeing. The patient was not on any other treatment/medication during the entire treatment. After uninterrupted therapy for six months there was an increase in her bone density along with increase in energy level. The patient case study is an attempt to provide yoga and Ayurveda as an alternative/supportive treatment for remission management osteoporosis from breast cancer patients.
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Sharma, Purnandu, Ranjana Chhabra, Amit Singh, and Reshma P. Jogdand. "Non-surgical approach towards uterine fibroid and ovarian cyst with Yoga practice." Integrative Medicine Case Reports 1, no. 2 (2020): 28. http://dx.doi.org/10.38205/imcr.010228.
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A case of a 43 years old female with uterine fibroid and ovarian cyst was managed by an alternative, Non-surgical approach of yoga intervention. Yoga was practised under supervision daily twice a day for three months showed significant recovery from ovarian Cyst and reduction in uterine fibroid size. A diagnosis, where surgery was suggested as the only option, yoga has been found to be effective treatment modality in prevention and management.
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Narayanan, Amudha Rani. "Subjective study on potts spine with therapeutic yoga intervention." Integrative Medicine Case Reports 1, no. 2 (2020): 32. http://dx.doi.org/10.38205/imcr.010232.
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This is a qualitative single subject intervention assessment involving the treatment of a 58 year old man, diagnosed with para-vertebral abscess due to tubercular pott’s spine with Diabetes since 2008, administered with neuro anaesthesia for pain management, which could not succeed in providing complete relief and hence a parallel attempt was made to treat the same through an integrative mind-body approach to resolving pain. Basic challenges in this process were to conceptualize a personalized approach based on the constitution and personality of the seeker and selection of specific tools of yoga therapy to suit the individual’s requirement. Adoption of yoga therapy involving synergized techniques resulted in holistic cure in a significantly reduced time interval. However, more studies are required to be adopted in the same manner to strengthen the line of the efficacy of such therapies in similar cases.
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Sabharwal, Pooja, John Fagen, Rima Dada, Ashok Sharma, Chandra Shekher Kaushik, Ashutosh Chaturvedi, and Priyanka Bhardwaj. "Integrating bioinformatics and epigenetics with Ayurveda-a possible contribution towards COVID-19 fight." Integrative Medicine Case Reports 1, no. 2 (2020): 39. http://dx.doi.org/10.38205/imcr.010239.
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The entire world is struggling from the COVID-19 pandemics. Scientific community all around the world have been looking for any possible measure to fight against this dreadful disease. Ayurveda, the traditional Indian system of medicine, has immense potential to contribute towards this pandemic both in prevention and management. But Ayurveda fraternity has the challenge to explain the available possible measures in contemporary language. The science of bioinformatics & epigenetics has provided possibility for scientific & contemporary explanation of Ayurvedic interventions.
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Jyoti, Saras. "Yoga and Cardiovascular Health Trial (YACHT): a UK-based randomized mechanistic study of a yoga intervention plus usual care versus usual care alone following an acute coronary event, BMJ Open 2019;9:e030119." Integrative Medicine Case Reports 1, no. 2 (2020): 45. http://dx.doi.org/10.38205/imcr.010245.
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Over the years Yoga has gained popularity throughout the world because of its various health benefits. Yoga is mind-body intervention which includes breathing, body postures and meditation (1). The studies on Yoga have documented to lower the stress and depression and are believed to improve biological cardiovascular risk factors (2–4). Cardiac rehabilitation (CR) is a program designed to strengthen cardiovascular health if you have experienced the heart related problems, and it has been shown to improve cardiovascular mortality and hospital re-admissions in patients with coronary heart disease (CHD). Yoga could, therefore, be a useful addition to CR. In this UK-based randomized report (Yoga and Cardiovascular Health Trial (YACHT), the hypothesis was that Yoga could be related to primarily with improvements in cardiovascular function in patients suitable for CR.
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Kaur, Navneet, Shweta Ahuja, Kanupriya Sharma, Rakesh Malik, Kavita Bakshi, Surinder Pal, Gurmeet Singh, Sarika Dhiman, Kiran Sharma, and Neeru Malik. "Confronting the potential role of Yoga in the molecular profile of rural high-risk women for Diabetes: a pilot study." Integrative Medicine Case Reports 2, no. 2 (2021): 38. http://dx.doi.org/10.38205/imcr.020238.
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Background and purpose: Yoga has been shown to have established beneficial impact through many previous studies. The mind-body practices like Yoga have an ameliorating effect on diabetes and prediabetes. The majority of prior published literature focused their attention on the glucose parameters in diabetic and prediabetic pathology. The purpose of the present pilot study is to explore the effect of AYUSH-approved Diabetic Yoga Protocol (DYP) on selected angiogenesis and neurogenesis markers in high-risk rural women for Diabetes. Methods: Total 15 high-risk women for Diabetes were selected from rural area of Chandigarh, for a 3-month DYP intervention. The pre-post single group experimental research design was implemented in the study. The changes in angiogenesis, neurogenesis parameters, and leptin were assessed at baseline and after 3 months after DYP intervention. Results: The result of the present study revealed that after 3 months of DYP intervention the statistically significant improvements were noticed on serum VEGF levels (p = 0.039). The improvements in angiogenin and BDNF levels were also seen after DYP practice. Conclusion: The results highlight the potential role of DYP on cellular growth and neuronal survival. Keywords: Diabetic Yoga Protocol, Indian Diabetes Risk Score, Prediabetes, angiogenesis, neurogenesis.
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Tripathi, Satyam, Kiran Shenoy, Mika Azuma, Nishant Dixit, Sandra Thiemann-Müller, Amit Singh, Barbara Ettenhofer, et al. "International Conference in Integrative Medicine ICIM – 2020." Integrative Medicine Case Reports 2, no. 1 (2021): 4. http://dx.doi.org/10.38205/imcr.020104.
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International Conference Integrative Medicine – 2020 was organised from September 04 to 06, 2020 by Union Yoga Ayurveda (Singapore) and Central Council of Research in Yoga and Naturopathy (India). The theme of this conference was “Challenges and Opportunities for Integrated Remedies for Cancer”. Integrative remedies is an inclusive approach of practicing medicine in a way that selectively incorporates elements of alternative medicine into comprehensive treatment. It can help people with communicable and non-communicable diseases such as cancer, (1,2) persistent pain, (3) diabetes management (4) and many other conditions to manage their symptoms and improve their quality of life. Integrative medicine has healing-oriented approach that can give a wider and wholesome perspective towards the disease and its relation to human body. Another role of integrative medicine is preventing future health issues before they arise and setting the foundation for overall positive health. ICIM welcomed distinguished experts from various streams of healthcare in this conference and shared their experience and understanding as per their respective system of medicine under one roof.
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Kumar, Phaneendra. "Diabetes management with practice of Yoga Asanas and 2 spoons of Amla Juice and Turmeric for 90 days." Integrative Medicine Case Reports 2, no. 1 (2021): 22. http://dx.doi.org/10.38205/imcr.020122.
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This case study is of a Diabetic person who works as an IT software engineer in Bangalore. Yoga Therapy Workshop was organized for 3 weeks (15 working days) in IT Company. The person showed interest in implementing the yoga therapy protocol for a longer duration to control her Diabetes. Her sense of well-being improved within one week of following the protocol which included Asanas, Meditation, Pranayam and Home Remedies such as Amla juice with Turmeric. She practiced yoga regularly and consumed 2 tablespoons of Amla Juice with 1 gram of Turmeric on an empty stomach for 90 consecutive days. She was not on any medication since she was diagnosed as a diabetic. Yoga has shown significant improvement in reversing the patient’s diabetes condition and returning her blood sugar levels to normal range.
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Bhadriraju, Kiran. "Experience of a flu-like illness in the time of COVID-19 and a potential role for turmeric in alleviating symptoms: a case study." Integrative Medicine Case Reports 2, no. 1 (2021): 19. http://dx.doi.org/10.38205/imcr.020119.
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Turmeric has been known in India since the time of the writing of the Charaka Samhita as a remedy for a wide range of illnesses, including respiratory illnesses. Laboratory investigations in cultured cells in the past several decades have shown that turmeric and its constituents influence signaling pathways and transcription factor activity, changes that are not incompatible with it having a beneficial effect. However, there are currently no rigorously designed modern investigations into the clinical efficacy of turmeric for respiratory illnesses. Here, the consumption of turmeric together with warm milk is anecdotally reported to have provided acute relief from severe congestion during a recent flu-like illness. Since the safety of turmeric has already been demonstrated by thousands of years of use, this report attempts to motivate the direct testing of its clinical efficacy for moderating the severity of flu-like respiratory illnesses in robustly designed clinical trials.
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Dixit, Nishant. "Thalamic Gamma Aminobutyric Acid Level Changes in Major Depressive Disorder After a 12-Week Iyengar Yoga and Coherent Breathing Intervention." Integrative Medicine Case Reports 2, no. 1 (2021): 32. http://dx.doi.org/10.38205/imcr.020132.
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Although yoga is considered as a science for spiritual growth of mankind, many studies have shown that various streams of yoga render many physical as well as psychological benefits to the practitioners. Studies based on Yogic intervention (YI) on Major Depressive disorders (MDD) have shown extremely positive outcomes in recent times (1,2). The antidepressant medications which target the monoamine framework were unable to answer to the neurobiological mechanisms of MDD. Gamma aminobutyric acid (GABA), an amino acid neurotransmitter is known to be an important factor in the pathophysiology of mood disorders (3). In this US based study the design was to track the changes in GABA in MDD through a Yogic Intervention based on Iyenger yoga tradition. The study reports that YI does influence the change in GABA level through the stimulation of parasympathetic response.
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Jogdand, Reshma P., Amit Singh, and R. Nagrathna. "Role of Integrative Medicine in Oncology for longevity and Quality of life: A Case Report." Integrative Medicine Case Reports 2, no. 1 (2021): 10. http://dx.doi.org/10.38205/imcr.020110.
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A patient with Adenocarcinoma of lungs diagnosed in (Sep 2014) without any co-morbidity like –DM-2, HTN. Patient received 5 cycles of Chemotherapy and 10 sessions of Radiotherapy followed by oral hormonal therapy for 2 yrs which shows significant reduction in size of nodule in lungs. In 2016 PET scan showed lung nodules have increased in size and new lesions were found in brain, shoulder and L5 region with symptoms of pleural effusion, imbalance in walking, difficulty in breathing and pain in left shoulder and lumbar region. In Dec 2016, he underwent naturopathy treatment like mud therapy and acupressure with vitamin supplements B17, B15, zinc, Tibetan medicine and Ayurveda medications significant improvement in symptoms. In Sep 2017 participant was admitted in Oncology Department of Arogyadhama with present history of generalized weakness, severe shoulder and back pain as well as change in walking gait due to weakness of lower limbs, breathlessness, insomnia and anorexia. He was advised Integrative Oncology treatment module which consists of yoga, Naturopathy, Ayurveda and Holistic Diet along with conventional medicine. There was significant improvement in breathlessness, muscular strength in lower limb, quality of life (QOL) and reduction in pain in shoulder and back, Improvement in walking gait after the 1 month of treatment. The present case study is an attempt to provide integrative medicine (yoga Ayurveda, Naturopathy, Conventional Medicine) for the promotion of positive health and management of pulmonary Adenocarcinoma.
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, Sheetal, and Subodh Tiwari. "Integrated Medicine a solution to COVID-19 – A Case Report." Integrative Medicine Case Reports 2, no. 1 (2021): 25. http://dx.doi.org/10.38205/imcr.020125.
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More than 213 countries are effected by the global pandemic of COVID-19, which has caused death of more than 500 thousand people around the world. Even after taking all the precaution, one can still get infected with COVID-19. The whole world is working to find a vacation, where as in alternative system of medicine is focusing on Immunity Boosting helping COVID-19 effected people. The case report shows how Yoga and Ayurveda has helped a COVID-19 positive 84 year’s old man to recover.
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Jyoti, Saras, Ram Gopal Parihar, and Ajay Gandhi. "Neurotherapy Intervention: A novel approach of healing." Integrative Medicine Case Reports 2, no. 1 (2021): 28. http://dx.doi.org/10.38205/imcr.020128.
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Background: Neurotherapy is an alternative and complementary medicine originated in India. It is drugless holistic treatment founded and developed by Sh. Lajpatrai Mehra respectfully called “Guruji” by using ancient knowledge of ‘Nadi Vigyan’ (knowledge of nervous system), Ayureveda and principles of Anatomy and Physiology. Summary: t uses the finding of medical physiology but views them from a uniquely and refreshing approach, one that negates the use of medicines or drugs. Supported by basis of physiology, Dr. Lajpatrai Mehra (Guruji) has combined these palpations with symptoms and related them with various health conditions. Key message: The therapy acts on root-cause of the disease. It uncovers the root cause of the disease and cures the same in a sophisticated manner without the use of drugs or medication. It is simple therapy with potential to normalize or revive the functioning of the organs
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Jogdand, Reshma P., Shekhar Mukhiya Sunuwar, Amit Singh, and R. Nagrathna. "Integrated Approach of Yoga Therapy towards Chronic Low Back Pain: A Case Report." Integrative Medicine Case Reports 2, no. 1 (2021): 15. http://dx.doi.org/10.38205/imcr.020115.
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This case report represents the patient of lower back pain (LBP) who visited Arogyadhama (SVYASA University, Bangalore). Patient was suffering from low back pain and multiple joint pain at the time of visit and 14 days Yoga intervention was provided to the patient for pain management, which helped the patient in relieving the pain and improving the muscular strength and quality of life significantly. The present case study is an attempt to provide IAYT (Integrated approach of Yoga therapy) practices in combination with naturopathy and physiotherapy for the maintenance of LBP profile and symptoms.
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Ramadass, S. A., Lancy D’souza, Karthik Pandit, Madhu Karnat S, and Ulrich Berk. "Agnihotra as an inexpensive method to treat HIV/AIDS – A pilot study." Integrative Medicine Case Reports 2, no. 1 (2021): 6. http://dx.doi.org/10.38205/imcr.020106.
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Background: Despite four decades of searching, no vaccine exists yet for HIV/AIDS, and it is still a big problem in many countries of the world. Purpose: Finding a simple method which is affordable, and which could help avoid side effects which the commonly used antiretroviral drugs often show, is the need of the moment. Method: A group of HIV positive children have been performing daily sunrise/sunset Agnihotra themselves under supervision for two years. Data were collected on viral load and CD4 counts before and after that. Repeated measure ANOVA was employed to find out the effectiveness of Agnihotra on reduction of viral load and increase in CD4 count. Results: Data shows general health improved measurably as viral load went down and CD4 values increased. Conclusion: These preliminary results show good potential of Agnihotra for HIV/AIDS patients and a randomized controlled trail is suggested.
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Maity, Kalyan, Vijaya Majumdar, Amit Singh, and Akshay Anand. "A recipe for Policy research in AYUSH educational and research programs." Integrative Medicine Case Reports 2, no. 1 (2021): 1. http://dx.doi.org/10.38205/imcr.020101.
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Yoga, Ayurveda, and Siddha represent the ancient science of healthy living originated in India. Some of the oldest texts from around 5000 years back, such as Vedas and Upanishads, provide evidence of such lifestyle. Many seals and fossils from Indus Valley Civilization authenticate the practice of Yoga in ancient India. According to yogic tradition, Shiva, one of the Hindu Gods, is the first yogi (Adi yogi) and the first teacher (Adi Guru). The meticulous practice of Yoga is widely believed to play a major role to overcome mental and physical suffering and leads to self-regulation, and finally to self-realization or liberation. Since the Pre-Vedic period around 2700 B.C., people started practicing Yoga. Later on, Patanjali Maharshi (between 3rd to 6th centuries BC) systematized and codified knowledge of Yoga through his Yoga Sutras. Later, with the help of many sages and masters, Yoga spread through different traditions, lineages and Guru-shishya parampara. Various Yoga schools viz. Jnana, Bhakti, Karma, Raja, Dhyana, Patanjali, Kundalini, Hatha, Laya, Jain, Buddha, Hatha etc. which follow their own practice, principles and tradition. However, they all lead to the same goal. The history of modern Yoga started in 1893 when the Parliament of Religions was held. After that many yogacharya, teachers and practitioners tried to spread Yoga, not only in India but worldwide (1). One of the milestones in the history of Yoga has been the adoption of the International Day of Yoga. The Honorable Prime Minister Sri Narendra Modi addressed the world community on 27th September 2014 in 69 sessions of the United Nations General Assembly (UNGA) (2). The proposal was approved on 11th December 2014 by 193 members of UNGA to establish 21 June as “International Day of Yoga”. Six months later after passing the resolution and confirmation to establish IDY, the first IDY held in 2015. Several Yogic events were organized and publicized throughout India as well as abroad and got national and international publicity that Yoga has originated from Indian culture. The essential and pivotal role of Yoga in education, pedagogy, curriculum, as well as clinical research has been realized well across the globe (3). To achieve the same, AYUSH Ministry was established November 9, 2014 (http://ayush.gov.in) to facilitate research and educational activity in Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy. The existence and excellence of Yoga-based researches in the premier Institutes of India is another milestone towards the implementation of yogic sciences in the academic sphere. Several Yoga departments and centers in the premier Institutes and central universities of India, their existence and establishment, is the result of the consultative meeting on Yoga Education in Universities held in Bangalore on 2nd January 2016, chaired by the Hon’ble Minister for Human Resource Development in the presence of Vice-Chancellors from Indian universities. It was resolved to set up a Department of Yogic Art and Science in the Universities and constitute a committee on Yoga Education in universities to look into various aspects pertaining to setting up of these Departments. Further, collaborative efforts were made to support Psychology, Philosophy, and Yogic Science at different collaborating organizations, by utilizing their respective expertise, knowledge, resources and infrastructure (https://www.nhp.gov.in/list-of-yoga-institutes_mtl). The aim of such centers was to understand deeper knowledge of Yoga philosophy and Yoga therapy based on classical Yogic texts. For the last several years, S-VYASA University has been doing research on evidence-based Yoga & its application, to prevent diseases and to promote positive health (https://svyasa.edu.in/Research_Publications.html). Swami Vivekananda Yoga Anusandhana Samsathana (S-VYASA), established in 1986, is a pioneer Institute in the field of Yoga Research. It is the first and foremost Institute with a broad vision of scientifically evaluating yoga, its applications, and policies led by Dr. H R Nagendra.
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Dutta, Abhijit, and Shubhamoy Ghosh. "Homeopathy and COVID-19 Pandemic in India." Integrative Medicine Case Reports 2, no. 2 (2021): 36. http://dx.doi.org/10.38205/imcr.020236.
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In the past few months, the Coronavirus infection (COVID-19/SARS-CoV-2) has invaded the globe with its infectious nature. The adverse situation and panic resulting from it has put the whole medical fraternity in a state of worry. Every country has engaged itself to fight with this deadly situation. History has rarely seen such rapidity in the development of therapies for any epidemic. Starting from Hydroxychloroquin, Remdesivir to Plasma therapy, or many of the opinion-based (or supported by weak/empirical evidence) therapies have been used.
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Singh, Pawandeep. "Case Study of a 22-year-old student suffering from crippling migraine attacks." Integrative Medicine Case Reports 2, no. 2 (2021): 58. http://dx.doi.org/10.38205/imcr.020258.
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A 22 year old patient with symptoms of intense migraine with history of headaches that sometimes lasted upto 2 days have made her bedridden completely. The patient ignored the mild headache which were started 4 years back. Slowly the episodes started increasing in intensity and duration ultimately culminating in a fear psychosis as the attacks did not have any fixed pattern and could strike anywhere at any time. The patient consulted many consulted several doctors for many months and had even tried acupressure but failed to find any relief from the headache. The patient approached Rudraksh Ashtang Yoga Center and enrolled herself for Yoga therapy. After 6 months of Yoga intervention the patient was back to her normal routine life.
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Maity, Kalyan. "Yoga in correctional settings: A randomized controlled study. Frontiers in Psychiatry. 2017 Oct 16; 8:204." Integrative Medicine Case Reports 2, no. 2 (2021): 69. http://dx.doi.org/10.38205/imcr.020269.
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Yoga is a holistic approach and it is quite difficult to understand the specific effects of Yoga for its many aspects such as Asana, Pranayama, Meditation, etc. Inspite of these challenges, scientific study on Yoga has been grown optimally. Several studies have shown the positive outcome of Yoga on various psychological and physiological parameters such as stress, anxiety, depression, memory, aggressiveness, etc. ( , ). Prison population is vulnerable to different psychiatric morbidities and often represent antisocial behavior ( , ). A randomized control trial has shown a significant improvement in perceived stress, positive affect, and psychological distress in prisoners after 10 weeks of Yoga practice ( ). A few meta-analysis has also suggested the positive effect of Yoga and meditation on psychological well-being and behavioral functioning in the prison population. The study has revealed that 10 weeks Yoga was associated with increased positive affect, impulse control, psychological well-being, sleep quality, and decreased aggressiveness, stress, and negative affect.
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Koul, Diksha, Jasmine K. Khosla, Ravi S. Manhas, Devtulya Chander, and Asha Chaubey. "COVID-19 prevention and management: Potential applications of humic substances." Integrative Medicine Case Reports 2, no. 2 (2021): 61. http://dx.doi.org/10.38205/imcr.020261.
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Background: COVID-19 pandemic has forced the human population to rethink over the lifestyle and food habits being followed by them. During the current scenario, when cases of more virulent new strain are emerging and specific treatment are still underway, we must look back to the Darvin’s theory of “Survival of the fittest” and in order to sustain the pandemic, we must follow the rule “Prevention is better than cure”. Traditional Medicinal System can bring possible solution including prevention and control of COVID-19. Humic substances have been used for antiviral activities, signifying that it has potential applications in the management and prevention of infectious diseases. Summary: Present article is focused on the assessment of the naturally occurring humic substances, which are major constituents of Shilajit, being used in traditional system of medicine and can be used against for the prevention of COVID-19. Key message: Humic substances not only improve the immune system, but also have anti-inflammatory, antioxidant and antiviral activities against human RNA viruses. Therefore, while the entire world is preparing to deal with alarming threat of community spread of COVID-19, Humic substances may play a vital role in improving the innate immunity for prevention and management of SARS-CoV-2 infection
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Pal, Surinder, Amarjeet Singh, and Akshay Anand. "Analysis of Radio diagnostic test referrals in government hospitals." Integrative Medicine Case Reports 2, no. 2 (2021): 34. http://dx.doi.org/10.38205/imcr.020234.
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In any treatment taken by patient, cost is an important dimension. These days, diagnostic tests comprise of a significant part of the health cost borne by patient for the treatment. Catastrophic expenditure is a commonly discussed issue by the health care administration. It is often argued that, outsourcing of the medical diagnostic tests is quite frequent. Daniel et al observed in their research survey that there were so many institutes which were outsourcing the tests.
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Hemalatha, A., Y. Rosy Ayda, V. Venugopal, and S. T. Venkateswaran. "Efficacy of naturopathic and yogic interventions in morbid obesity: A case study." Integrative Medicine Case Reports 2, no. 2 (2021): 47. http://dx.doi.org/10.38205/imcr.020247.
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Obesity is an accumulation of body fat, resulting in adverse health effects. The prevalence of overweight and obesity among population aged 30 years and above was 42 percent and 12 percent globally, respectively. This study presents the progressive onset of obesity in an adult male and examines the different risk factors as well as NYI for morbid obesity. A 24-year-old self-employed catering employee underwent Naturopathic and Yogic interventions (NYI) for a period of 30 days. He was assessed for anthropometric measurements, haematological assessments and perceived stress scale. Statistical tests using Excel were done with the Data Analysis ToolPak. In our case, we observed that the weight loss progressed as we increased the duration of the NYI.
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Tiwari, Subodh, Shruti Sharma, and Anita Verma. "Integrated therapy as a tool to help fight asymptomatic COVID-19: A case report." Integrative Medicine Case Reports 2, no. 2 (2021): 55. http://dx.doi.org/10.38205/imcr.020255.
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COVID-19 is a rapidly changing and evolving situation and is extremely challenging to the humankind since it is highly infectious. Around 80% of the COVID-19 patients are asymptomatic but still need special care so that they don’t develop any further serious complications in due course of infection. The aim of present case study was to assess the effect of integrated therapy of yoga and Ayurveda on vital parameters of a COVID-19 positive asymptomatic patient. He was found to be COVID-19 positive with ORF CT value of 29.85. He remained asymptomatic throughout the course of disease. Vital parameters such as body temperature, oxygen saturation, and heart rate remained optimal throughout the course of infection. This was probably due to physical activity such as walking, yoga and Ayurvedic medications which helped in building of immunity. This further prevented progression of the disease to moderate/severe stage and there were no unanticipated events. The patient was rechecked after 8 days and was found to be COVID-19 negative. This implies that Yoga and Ayurveda treatment is effective in controlling symptoms of COVID-19 and prevention of disease progression.
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Tripathi, Satyam, and Mika Azuma. "A case study on effect of integrative medicine with combination of hrudaydhara (heart stimulation) and yoga therapy on ejection fraction of patient with history of hypertension." Integrative Medicine Case Reports 2, no. 2 (2021): 50. http://dx.doi.org/10.38205/imcr.020250.
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Today, cardiovascular disease has become a global health issue owing to high-stress in personal and professional environments and adverse lifestyle changes with neglected diet and decreased physical activity. Ayurveda and Yoga aim not only to treat diseases but to also reinforce measures to promote health and well-being. Holistic approaches in these two sciences can be used in an effective way to improve cardiovascular health. A blend of Yoga practices and Ayurveda therapy is quintessentially useful for both the mind and body. Sun Salutation and Mind Sound Resonance Technique (MSRT) meditation work on calming the mind and allow the body to transition into a high energy state for moderate exercise. This is followed ultimately by Hrudaydhara of Ayurveda which focuses on relaxing the intercostal and cardiac muscle which in turn reduces chest discomfort of the patient and eventually improves the ejection fraction of the heart. This shows evidence that integrating yoga and ayurvedic practices with conventional medicine can be a collaborative approach while managing cardiovascular ailments.