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Journal articles on the topic 'Imidazole; Benzothiazole and Antibacterial and Antifungal activities'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Purvesh, J. Shah. "Preparation, Characterization and Biological Screening of Novel Imidazoles." Journal of Progressive Research in Chemistry 2, no. 1 (2015): 54–60. https://doi.org/10.5281/zenodo.3970044.

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The 4-benzylidene-2-(4-methoxyphenyl)oxazol-5(4H)-one (B) has been prepared from cyclo condensation reaction between hippuric acid (A) with p-anisaldehyde. A series of 4-benzylidene-1-(substitued-2- benzothiazolyl)-2-(4-methoxyphenyl)-1H-imidazol-5(4H)-one (D1-6) have been synthesized from 2-amino substituted benzothiazole (C1-6) by condensation reaction with 4-benzylidene-2-(4-methoxyphenyl) oxazol-5(4H)-one (B). The synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR and Mass spectral data. All the compounds were screened for their antibacterial and antifungal activities.

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2

Rawat, Bhupender Singh, and S. C. Mehra. "SYNTHESIS OF SOME NEW 1, 3-DI METHYL SUBSTITUTED GUANIDINE WITH POSSIBLE ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY." Green Chemistry & Technology Letters 2, no. 3 (2016): 138–40. http://dx.doi.org/10.18510/gctl.2016.233.

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The compounds containing thiazole, thiadiazole, oxazole, oxadiazole, imidazole, pyrimidine, pyridine & benzothiazole rings have been found to exhibit broad spectrum of biological activities.Derivatives of 1, 2, 4-thiadiazole and 1, 2, 4-thiadiazolidines exhibit antibacterial and antifungal activity1. Thiazolyl guanidines2 and various substituted aryl guanidine’s have been found to exhibit antibacterial & antifungal activities3.Keeping all these views in mind attempts were made to synthesized some new 1,3-di methyl Substituted Guanidine.In the present work 2,4 Dimethyl -3,5-(di Aryl imi

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3

Baldaniya, B. B. "Synthesis, Characterization and Biological Activity of 5-Arylidene-3-(6,7-dicloro-1,3-benzothiazol-2-yl)-phenyl-3,5-dihydro-4H-imidazol-4-ones." E-Journal of Chemistry 7, no. 1 (2010): 81–84. http://dx.doi.org/10.1155/2010/264036.

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Some novel 5-arylidene-3-(6,7-dichloro-1,3-benzothiazol-2-yl)-2-phenyl-3,5-dihydro-4H-imidazol-4-ones (6a-q)have been synthesized and characterized by elemental analyses, IR, NMR, and mass spectra. The products have been evaluated for antibacterial and antifungal activities against different strains of bacteria and fungi.

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4

Eriamiatoe, I. O., B. J. Owolabi, V. Mzozoyana, H. C. Ndibe, and T. Eriamiatoe. "The Potential Antifungal and Antibacterial of 5- Chloro-1- Methyl- 4- Nitroimidazole." International Journal of Research and Scientific Innovation XI, no. VII (2024): 366–72. http://dx.doi.org/10.51244/ijrsi.2024.1107027.

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Imidazole is a nitrogen-containing heterocyclic ring that possesses biological and pharmaceutical importance. The imidazole ring is a constituent of several important natural products, including purine, histamine, histidine, and nucleic acid, while the nitroimidazole and its derivatives possess an extensive spectrum of biological activities such as antibacterial, anticancer, antitubercular, antifungal, analgesic, and anti-HIV activities. This paper aims to evaluate the in vitro antifungal and antibacterial activities of 5-chloro-1-methyl-4-nitroimidazole. The synthesis of this compound was car

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5

Morsy, Mohamed A., Enas M. Ali, Mahmoud Kandeel, et al. "Screening and Molecular Docking of Novel Benzothiazole Derivatives as Potential Antimicrobial Agents." Antibiotics 9, no. 5 (2020): 221. http://dx.doi.org/10.3390/antibiotics9050221.

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The burden of antibiotic resistance necessitates a continued search for new antimicrobials. We evaluated the antimicrobial activities of novel benzothiazoles synthesized by our group. Antibacterial activity was evaluated in vitro in Staphylococcus aureus, Bacillus subtilis, and Escherichia coli, while the antifungal activity was tested in Candida albicans and Aspergillus niger, and expressed as the minimum inhibitory concentration (MIC; µg/mL). MIC values of benzothiazole compounds ranged from 25 to 200 µg/mL. Compounds 3 and 4 gave high antibacterial and moderate antifungal activities, while

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6

Jasiewicz, Beata, Karolina Babijczuk, Beata Warżajtis, et al. "Indole Derivatives Bearing Imidazole, Benzothiazole-2-Thione or Benzoxazole-2-Thione Moieties—Synthesis, Structure and Evaluation of Their Cytoprotective, Antioxidant, Antibacterial and Fungicidal Activities." Molecules 28, no. 2 (2023): 708. http://dx.doi.org/10.3390/molecules28020708.

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In the search for new bioactive compounds, a methodology based on combining two molecules with biological properties into a new hybrid molecule was used to design and synthesize of a series of ten indole derivatives bearing imidazole, benzothiazole-2-thione, or benzoxazole-2-thione moieties at the C-3 position. The compounds were spectroscopically characterized and tested for their antioxidant, antibacterial, and fungicidal activities. The crystal structures were determined for five of them. Comparison of the closely related structures containing either benzothiazole-2-thione or benzoxazole-2-

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7

ZOMORODIAN, K., S. KHABNADIDEH, L. ZAMANI, K. PAKSHIR, and M. TAJADDOD. "EVALUATION OF ANTIFUNGAL AND ANTIBACTERIAL ACTIVITY OF SOME NEW BENZIMIDAZOLE DERIVATIVES." Latin American Applied Research - An international journal 48, no. 2 (2018): 125–29. http://dx.doi.org/10.52292/j.laar.2018.270.

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The extensive use of antifungal drugs and their resistance against fungal infections have led to discover new antimicrobial compounds. We previously described synthesis of some new derivatives of 2-methylbenzimidazole (1a-5a) and 5,6dimethylbenzimidazol (1b-5b). Here we evaluated the antimicrobial activities of these compounds against different species of micro organisms including gram positive and gram negative bacteria as well as fungi. Broth micro-dilution method as recommended by clinical and laboratory standard institute (CLSI) was used for this purpose. The results show compounds 2-Methy

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8

Duong Quoc, Hoan, Du Nguyen Duc, Luong Truong Minh, Thao Nguyen Thi Thach, and Hien Nguyen Thi Thu. "SYNTHESIS OF SOME BENZOTHIAZOLE ANILINE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITIES." Journal of Science Natural Science 67, no. 3 (2022): 68–74. http://dx.doi.org/10.18173/2354-1059.2022-0042.

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Three benzothiazole aniline derivatives 2a, 2b, and 2c were synthesized successfully by the reduction reaction of the respective nitro compound in neutral condition with Na2S2O4 in moderate yield. Structures of these derivatives were elucidated by IR, NMR, and MS analysis that referred to a strong agreement between spectral data and structures. Three compounds 2a, 2b, and 2c showed weak antioxidant, antibacterial and antifungal activities.

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9

Vaishnavi P. Bansod, Vinayak A. Katekar, and Swati Deshmukh. "A review: Synthesis characterization and in vitro anti-mycobacterial activity of some novel benzothiazole." GSC Biological and Pharmaceutical Sciences 25, no. 2 (2023): 169–79. http://dx.doi.org/10.30574/gscbps.2023.25.2.0433.

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Heterocyclic compounds, analogs, and derivatives have received a lot of interest recently because of their advantageous biological and pharmacological properties. Flexible substrates include the heterocyclic compounds that benzothiazole and its analogs can be used to synthesize. The benzothiazole nucleus is utilized to create a wide variety of pharmaceuticals. The biological activity of benzothiazole derivatives has recently undergone some intriguing alterations. These compounds stand out in the world of medicinal chemistry due to their high pharmacological potential. According to the World He

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Vaishnavi, P. Bansod, A. Katekar Vinayak, and Deshmukh Swati. "A review: Synthesis characterization and in vitro anti-mycobacterial activity of some novel benzothiazole." GSC Biological and Pharmaceutical Sciences 25, no. 2 (2023): 169–79. https://doi.org/10.5281/zenodo.10609199.

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Heterocyclic compounds, analogs, and derivatives have received a lot of interest recently because of their advantageous biological and pharmacological properties. Flexible substrates include the heterocyclic compounds that benzothiazole and its analogs can be used to synthesize. The benzothiazole nucleus is utilized to create a wide variety of pharmaceuticals. The biological activity of benzothiazole derivatives has recently undergone some intriguing alterations. These compounds stand out in the world of medicinal chemistry due to their high pharmacological potential. According to the World He

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11

K., Chandra Sekhar* Bandi Likhitha. "A Review Article on Recent Advances in The Pharmacological Diversification of Imidazole Derivative." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 342–58. https://doi.org/10.5281/zenodo.15128869.

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Imidazole is a nitrogen-containing heterocyclic compound that plays a vital role in biological and pharmaceutical sciences. Thus, the imidazole ring is a component of several natural products such as purine, histamine, and nucleic acid. The activity of the imidazole ring provides enormous scope in synthesizing various compounds containing pharmacological activities. In this literature, several imidazole derivatives have been described for their biological activities including antifungal, antiulcer, antiviral, anticancer, antibacterial, antitubercular, anti-inflammatory, analgesic, anthelmintic

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12

Osmaniye, Derya, Uğur Kayiş, Ülküye Dudu Gül, Yusuf Özkay, and Zafer Asım Kaplancıklı. "Synthesis, biological activity evaluation and molecular docking studies of novel thiazole derivatives." European Journal of Life Sciences 2, no. 1 (2023): 1–24. http://dx.doi.org/10.55971/ejls.1270394.

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Resistance to existing drugs develops because of insensible use of antibacterial and antifungal drugs. Therefore, there is a need for the development of new drug candidate compounds. The thiazole ring has many biological activities. It is possible to include antibacterial and antifungal activities among these activities. In addition to these, the thiazole ring has been preferred because it is the bioisostere of the imidazole ring in the structure of many antifungal drugs. For this purpose, within the scope of this study, 7 new thiazole compounds were synthesized, and their structure determinat

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13

Choudhari, Dinkar, Sunita Salunke-Gawali, Debamitra Chakravarty, et al. "Synthesis and biological activity of imidazole based 1,4-naphthoquinones." New Journal of Chemistry 44, no. 17 (2020): 6889–901. http://dx.doi.org/10.1039/c9nj04339j.

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Design and development of drugs in multi-drug resistant (MDR) infections have been of growing interest. The syntheses, structural studies, antibacterial and antifungal activities of imidazole-based 1,4-naphthoquinones are studied in this investigation.

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14

Verma, Amita, Sunil Joshi, and Deepika Singh. "Imidazole: Having Versatile Biological Activities." Journal of Chemistry 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/329412.

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Imidazoles have occupied a unique position in heterocyclic chemistry, and its derivatives have attracted considerable interests in recent years for their versatile properties in chemistry and pharmacology. Imidazole is nitrogen-containing heterocyclic ring which possesses biological and pharmaceutical importance. Thus, imidazole compounds have been an interesting source for researchers for more than a century. The imidazole ring is a constituent of several important natural products, including purine, histamine, histidine, and nucleic acid. Being a polar and ionisable aromatic compound, it imp

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15

Zubenko, Alexander, Victor Kartsev, Anthi Petrou, et al. "Experimental and In Silico Evaluation of New Heteroaryl Benzothiazole Derivatives as Antimicrobial Agents." Antibiotics 11, no. 11 (2022): 1654. http://dx.doi.org/10.3390/antibiotics11111654.

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In this manuscript, we describe the design, preparation, and studies of antimicrobial activity of a series of novel heteroarylated benzothiazoles. A molecular hybridization approach was used for the designing compounds. The in vitro evaluation exposed that these compounds showed moderate antibacterial activity. Compound 2j was found to be the most potent (MIC/MBC at 0.23–0.94 mg/mL and 0.47–1.88 mg/mL) On the other hand, compounds showed good antifungal activity (MIC/MFC at 0.06–0.47 and 0.11–0.94 mg/mL respectively) with 2d being the most active one. The docking studies revealed that inhibiti

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16

Mithlesh, Pawan K. Pareek, Hemraj Chippa, Ravikant, and Krishan G. Ojha. "Microwave synthesis of new biologically important 1,4-dihydropyridines containing benzothiazole moiety." Collection of Czechoslovak Chemical Communications 75, no. 3 (2010): 275–87. http://dx.doi.org/10.1135/cccc2009051.

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2,3,5,6-Tetrasubstituted-4-aryl-1-(6-ethoxybenzothiazol-2-yl)-1,4-dihydropyridines were synthesized by the reaction of 2-amino-6-ethoxybenzothiazole, an aromatic aldehyde and an active methylene compound in methanol by conventional or microwave irradiation method (solvent-free or with solid support). All compounds were tested for antibacterial and antifungal activities and the results were compared with standard drugs. Their acaricidal and antifeedant activities were also tested.

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17

Dziduch, Katarzyna, Sara Janowska, Sylwia Andrzejczuk, et al. "Synthesis and Biological Evaluation of New Compounds with Nitroimidazole Moiety." Molecules 29, no. 13 (2024): 3023. http://dx.doi.org/10.3390/molecules29133023.

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Heterocyclic compounds, particularly those containing azole rings, have shown extensive biological activity, including anticancer, antibacterial, and antifungal properties. Among these, the imidazole ring stands out due to its diverse therapeutic potential. In the presented study, we designed and synthesized a series of imidazole derivatives to identify compounds with high biological potential. We focused on two groups: thiosemicarbazide derivatives and hydrazone derivatives. We synthesized these compounds using conventional methods and confirmed their structures via nuclear magnetic resonance

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18

Salam, Shahana, and Rakesh Kumar Jat. "Imidazole Phenanthroline Derivatives: A Promising Application in Modern Medicine." Journal of Drug Delivery and Therapeutics 15, no. 6 (2025): 102–10. https://doi.org/10.22270/jddt.v15i6.7230.

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Purpose: The primary objective of this study is to create a new class of imidazole phenanthroline compounds that target the 1,10-phenanthroline core for its antifungal and antibacterial properties. Methods: Commercially available 1,10-phenanthroline (phen) was nitrated with potassium bromide in the presence of sulfuric and nitric acids to get 1,10-phenanthroline-5,6-dione (phendione), an intermediate molecule, which served as the starting compound for the synthesis of 1H-imidazo [4,5-f] [1,10] phenanthroline compounds. This intermediate product was dissolved in glacial acetic acid and then rea

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19

Journal, Baghdad Science. "Synthesis and Evaluation of Antimicrobial activity of several new Maleimides to Benzothiazole moiety." Baghdad Science Journal 10, no. 3 (2013): 658–72. http://dx.doi.org/10.21123/bsj.10.3.658-672.

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In this work, a series of new maleimides linked to substituted benzothiazole moiety were synthesized. Synthesis of these new cyclic imides were performed via three steps, the first one involved preparation of a series of 2-aminobenzothiazole substituted with different substituents via reaction of different primary aromatic amines with ammonium thiocyanate and bromine in glacial acetic acid. The prepared 2- amino benzothiozoles were introduced in the second step in reaction with maleic anhydride producing a series of N-(substituted benzothiazole-2-yl) maleamic acids.The resulted maleamic acids

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20

Azzawi, Ahlam Marouf AL, and Suroor Abdul Rhahman Mahdi. "Synthesis and Evaluation of Antimicrobial activity of several new Maleimides to Benzothiazole moiety." Baghdad Science Journal 10, no. 3 (2013): 658–72. http://dx.doi.org/10.21123/bsj.2013.10.3.658-672.

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In this work, a series of new maleimides linked to substituted benzothiazole moiety were synthesized. Synthesis of these new cyclic imides were performed via three steps, the first one involved preparation of a series of 2-aminobenzothiazole substituted with different substituents via reaction of different primary aromatic amines with ammonium thiocyanate and bromine in glacial acetic acid. The prepared 2- amino benzothiozoles were introduced in the second step in reaction with maleic anhydride producing a series of N-(substituted benzothiazole-2-yl) maleamic acids.The resulted maleamic acids

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21

Rajareddy, Aleti 1. *. Srinivasa Murthy Muppavarapu 2. "SYNTHESIS AND CHARACTERIZATION OF NOVEL BENZOTHIAZOLE DERIVATIVES CONTAINING INDOLE MOIETIES WITH ANTIMICROBIAL ACTIVITIES." Journal of Scientific Research in Pharmacy 7, no. 10 (2018): 118–23. https://doi.org/10.5281/zenodo.1473391.

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<strong><em>ABSTRACT</em></strong> <strong><em>T</em></strong><em>he"(E)-5-chloro-1-((E)-1-((7-chloro-6-fluorobenzo[d]thiazol-2-yl)imino)ethyl)-3-(p-tolylimino)indolin-2-one" was to synthesize, purify, characterize and evaluate the biological activity of newly synthesized structural analogs of Benzothiazole derivatives Indole moieties. All these molecules (5a-5o) were characterized by FTIR, H<sup>1</sup>NMR and mass spectral analysis along with physical data. The biological potentials of the newly synthesized compounds are evaluated for their anti microbial activity</em><em> The stan

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Abdullah, Asmaa M., Abdull Jabar Kh Attia, and Sergei N. Shtykov. "Synthesis and Characterization of Novel Benzimidazole Derivatives using CdO NPs and their Application as Antibacterial and Antifungal Agents." Al-Mustansiriyah Journal of Science 35, no. 4 (2024): 52–63. https://doi.org/10.23851/mjs.v35i4.1572.

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Background: Benzimidazoles are a class of compounds characterized by a fusion of benzene and imidazole rings. This unique structure endows them with a broad spectrum of biological activities, making them invaluable in medicinal and pharmaceutical research. The benzene ring provides aromatic stability, while the imidazole ring offers a site for various chemical modifications, enhancing their versatility and functionality. Benzimidazoles are known for their diverse pharmacological properties, including antimicrobial, antiviral, anticancer, anti-inflammatory, and antiparasitic. Objective: Synthes

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23

Panda, S., та S. K. Dash. "A Comparative Study of the Inclusion Complexes of 2-[5'-benzylidene-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole and 2-[5'-(p-N,N-dimethylamino- benzylidene)-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole withβ-Cyclodextrin". E-Journal of Chemistry 8, № 3 (2011): 1030–37. http://dx.doi.org/10.1155/2011/265484.

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The compounds 2-[5'-benzylidene-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole and 2-[5'-(p-N,N-dimethylamino- benzylidene)-2'-phenyl-4'-oxo-1', 3'-thiazolidine]-1, 3-benzothiazole have been synthesized in their purest forms starting from 2-aminobenzothiazole. The inclusion complexes of the above compounds have been prepared with β-cyclodextrin to increase their solubility and bioaccessibility in polar medium. The formation of inclusion complexes have been ascertained by study of spectral characteristic before and after inclusion complex formation. The stability of inclusion complexe

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24

Rayenko, Gennady F., Olexandr S. Avksentiev, Vagiz Sh Saberov, et al. "Synthesis and the Antimicrobial Activity of Salt Carbenoid Compounds." Journal of Organic and Pharmaceutical Chemistry 20, no. 2 (2022): 14–26. http://dx.doi.org/10.24959/ophcj.22.258880.

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Aim. To synthesize aliphatic and aromatic derivatives of salt carbenoid compounds of the series of imidazole, benzimidazole, pyridine, pyrimidine and 1,3,4-oxadiazole containing fluorophenyl, cetyl or adamantyl substituents, and study their antimicrobial (antibacterial and antifungal) activities.Results and discussion. New derivatives of heterocyclic carbenoid salts and zwitterions based on the imidazole, benzimidazole, pyridine, pyrimidine and 1,3,4-oxadiazole heterocyclic systems containing fluorophenyl, cetyl or adamantyl substituents were synthesized. For this purpose, reactions of cycliza

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Barbarossa, Alexia, Jessica Ceramella, Alessia Carocci, et al. "Benzothiazole-Phthalimide Hybrids as Anti-Breast Cancer and Antimicrobial Agents." Antibiotics 12, no. 12 (2023): 1651. http://dx.doi.org/10.3390/antibiotics12121651.

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The benzothiazole nucleus is a major heterocyclic scaffold whose therapeutic potential has been thoroughly explored due to its structural simplicity and ease of synthesis. In fact, several benzothiazole derivatives have been synthesized over time, demonstrating numerous pharmacological properties such as anticancer, antimicrobial, anti-inflammatory, and antioxidant activities. Herein, we propose a new series of benzothiazole-phthalimide hybrids obtained by linking the phthalimide moiety to differently substituted benzothiazole nuclei through the N atom. These compounds have been screened for t

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26

Lungu, Lidia, Caleria Cucicova, Svetlana Blaja, et al. "Synthesis of Homodrimane Sesquiterpenoids Bearing 1,3-Benzothiazole Unit and Their Antimicrobial Activity Evaluation." Molecules 27, no. 16 (2022): 5082. http://dx.doi.org/10.3390/molecules27165082.

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Based on some homodrimane carboxylic acids and their acyl chlorides, a series of fourteen 2-homodrimenyl-1,3-benzothiazoles, N-homodrimenoyl-2-amino-1,3-benzothiazoles, 4′-methyl-homodrimenoyl anilides and 4′-methyl-homodrimenthioyl anilides were synthesized and their biological activities were evaluated on five species of fungi (Aspergillus niger, Fusarium solani, Penicillium chrysogenum, P. frequentans, and Alternaria alternata) and two strains of bacteria (Bacillus sp. and Pseudomonas aeruginosa). The synthesis involved the decarboxylative cyclization, condensation and thionation of the sai

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Tejasri, Alla* Rohini Kontham K. Swarna Madhuri Vasudha Bakshi. "SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 2-CYCLIC AMINE BENZOTHIAZOLE DERIVATIVES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 04 (2018): 2635–43. https://doi.org/10.5281/zenodo.1220232.

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The synthesis of a new series of 2-(cyclic amine)-1, 3-benzothiazole derivatives were synthesized in satisfactory yield and evaluated for their anti-microbial activities. 2-(cyclic amine)-1, 3-benzothiazoles were synthesized by treating 2-chloro benzothiazole with various cyclic amines. Purity of all the compounds has been checked on thin layer chromatographic plate technique. The structures of these newly synthesized compounds were characterized by elemental analysis and spectral data like IR, 1HNMR, 13CNMR and mass spectroscopy. All the synthesized compounds have been screened for their anti

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Heda, Kavita. M. "Newly synthesized compounds from 2- hydrazino benzothiazole: Characterization, and evaluation of their antibacterial potential." International Journal of Advance and Applied Research 5, no. 23 (2024): 291–94. https://doi.org/10.5281/zenodo.13622529.

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Abstract:Serial of 1-tetra-O-benzoyl-β-D-glucosyl-3-(2)-hydrazino-1, 3-substituted benzothiozolyl thiocarbamide has been synthesized by the interaction  of   two pharmocophores,  tetra-O-benzoyl-β-D-glucosyl isothiocyanates and amine substituted 2-hydrazino-1,3-benzothiazoles in acetone medium. The reaction mixture was kept at room temp for 24 hrs. In acetone medium. Acetone is evaporated then product is recrystallised by petroleum ether (60-80%).  Benz-fused compounds have been employed in the synthesis of various compounds which show very potential pharmacologic

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Rao, B. Ramalingeswara, Mohana R. Katiki, Kommula Dileep, et al. "Synthesis and Biological Evaluation of Benzothiazole-piperazinesulfonamide Conjugates and Their Antibacterial and Antiacetylcholinesterase Activity." Letters in Organic Chemistry 16, no. 9 (2019): 723–34. http://dx.doi.org/10.2174/1570178615666181113094539.

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Two series of N-2-benzothiazolyl-4-(arylsulfonyl)-1-piperazineacetamides/propanamides were synthesized from substituted 2-aminobenzothiazoles and were assayed for their in vitro antimicrobial activities against a panel of different pathogenic bacterial strains such as Micrococcus luteus, S. aureus, S. aureus MLS-16, B. subtilis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella planticola and Candida albicans. Among the synthesized compounds 5e,f,g and 6g,h,i showed promising antifungal activity against C. albicans as compared to the reference drug, miconazole. Further, compounds 6g,h,i sho

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Ovonramwen, Oluwaseyi B., Bodunde J. Owolabi, and Abiodun Falodun. "Synthesis and antimicrobial activities of some new sulfonyl phenoxides." Tanzania Journal of Science 47, no. 2 (2021): 745–53. http://dx.doi.org/10.4314/tjs.v47i2.30.

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Four new sulfonyl phenoxides were synthesized through O-sulfonylation reaction of phenolic compounds with 5-chloro-1-ethyl-2-methylimidazole-4-sulfonyl chloride in good yield. FT-IR, 1H-NMR, 13C-NMR, and DEPT 135 NMR were carried out to characterize and the thin layer chromatography (TLC) confirm the purity. Antimicrobial activities of the sulfonyl phenoxides against Gram-positive (methicillin-susceptible Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Bacillus subtilis), Gram-negative (Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae), and Candida albica

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Dasari, Srinivasa Rao, Subbaiah Tondepu, Lakshmana Rao Vadali, and Nareshvarma Seelam. "Design, Synthesis and Molecular Docking Studies of Novel Pyrazole Benzimidazole Derivatives as Potent Antibacterial Agents." Asian Journal of Chemistry 31, no. 12 (2019): 2733–39. http://dx.doi.org/10.14233/ajchem.2019.22137.

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A novel series of pyrazole benzimidazole derivatives were synthesized and the structure of the final targets 4a-h were confirmed by IR, Mass, 13C NMR and 1H NMR spectral analysis. The new pyrazole core with imidazole and benzimidazoles derivatives were evaluated for in vitro antibacterial, antifungal activity against six bacterial strains significantly. In dispersion, 4c, 4f and 4g had the highest antibacterial activities on these microorganisms Bacillus subtilis B29, Escherichia coli E266, with zone of inhibition 21, 19 and 19 mm, respectively. Compounds 4a, 4c, 4h shows good antifungal activ

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Ayman, B. Farag, and M. Michael Adel. "Spectrophotometric study of the interaction between a novel benzothiazolethioglycoside as antimicrobial agent with bovine serum albumin." Chemistry Research Journal 2, no. 2 (2017): 66–72. https://doi.org/10.5281/zenodo.13956269.

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This study is concerned with the interaction of a newly synthesized antimicrobial agent (BTT) with bovine serum albumin (BSA). BTT is a novel benzothiazolethioglycosides that was prepared via reaction of the benzothiazole and 2-thioxoimidazolidin-4-one thiolate salts with tri- acetylated cyclic xylopyranosyl bromide. It was tested for antimicrobial activity against different bacteria and fungi and it exhibited interesting high antibacterial activities against Gram +ve bacteria while it showed no antibacterial activities against Gram -ve bacteria nor antifungal activity. Spectrophotometry was t

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H., A. Shindy, K. Khalafalla A., M. Goma M., and H. Eed A. "Synthesis, photosensitization and antimicrobial activity evaluation of some novel Merocyanine dyes." Chemistry International 2, no. 3 (2016): 114–20. https://doi.org/10.5281/zenodo.1470621.

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Novel acyclic and cyclic merocyanine dyes derived from the nucleu of furo [(3,2- d) pyrazole; imidazole]were prepared. The electronic visible absorption spectra of all the synthesized new cyanine dyes were examined in 95% ethanol solution to evaluate their photosensitization properties. Antibacterial and antifungal activities for some selected dyes were tested against various bacterial and fungal strains (Escherichia coli, Staphylococcus aureus, Aspergillus flavus and Candida albicans) to evaluate their antimicrobial activity. Structural identification was carried out via elemental analysis, v

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Sanapalli, Bharat Kumar Reddy, Akram Ashames, Dilep Kumar Sigalapalli, Afzal B. Shaik, Richie R. Bhandare, and Vidyasrilekha Yele. "Synthetic Imidazopyridine-Based Derivatives as Potential Inhibitors against Multi-Drug Resistant Bacterial Infections: A Review." Antibiotics 11, no. 12 (2022): 1680. http://dx.doi.org/10.3390/antibiotics11121680.

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Fused pyridines are reported to display various pharmacological activities, such as antipyretic, analgesic, antiprotozoal, antibacterial, antitumor, antifungal, anti-inflammatory, and antiapoptotic. They are widely used in the field of medicinal chemistry. Imidazopyridines (IZPs) are crucial classes of fused heterocycles that are expansively reported on in the literature. Evidence suggests that IZPs, as fused scaffolds, possess more diverse profiles than individual imidazole and pyridine moieties. Bacterial infections and antibacterial resistance are ever-growing risks in the 21st century. Onl

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Journal, Baghdad Science. "Synthesis , characterization and biological activity study of N-substituted sulfonamido maleimides substituted with different heterocycles." Baghdad Science Journal 7, no. 1 (2010): 641–53. http://dx.doi.org/10.21123/bsj.7.1.641-653.

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Eighteen new cyclic imides (maleimides) conncted to benzothiazole moiety through sulfonamide group were synthesized via multistep synthesis.The first step involved preparation of two maleamic acids N-phenylmaleamic acid and N-benzylmaleamic acid via reaction of maleic anhydride with aniline or benzyl amine.Dehydration of the prepared amic acids by treatment with acetic anhydride and anhydrous sodium acetate in the second step afforded N-phenylmaleimide and N- benzyl maleimide which in turn were treated with chlorosulfonic acid in the third step to afford 4-(N-maleimidyl) phenyl sulfonyl chlori

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Basantcev, Anton V., Andrey A. Danilin, Tatyana I. Vasileva, and Petr P. Purygin. "Synthesis of N-mono- and N,N-dialkylated imidazole derivatives based on (adamantyl-1)bromomethylketone and study of their antibacterial activity." Butlerov Communications 63, no. 7 (2020): 24–30. http://dx.doi.org/10.37952/roi-jbc-01/20-63-7-24.

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Different methods for the synthesis of N-mono- and N,N-dialkylated imidazole derivatives represent certain interest not only for organic chemistry, but also for medicine. N-alkylated imidazoles are the basis of drugs with antibacterial and antifungal activities. This allows us to consider them as efficient synthons for the synthesis of modern medicines. The quaternary imidazolium salts are applied as anticorrosive substances in petroleum industry due to their antibacterial activity against sulfur bacteria. The introduction of (adamantoyl-1)methyl group with high lipophilicity to the compositio

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Haroun, Michelyne, Christophe Tratrat, Katerina Kositzi, et al. "New Benzothiazole-based Thiazolidinones as Potent Antimicrobial Agents. Design, synthesis and Biological Evaluation." Current Topics in Medicinal Chemistry 18, no. 1 (2018): 75–87. http://dx.doi.org/10.2174/1568026618666180206101814.

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Background: Thiazole and benzothiazole derivatives, as well as thiazolidinones are very important scaffolds in medicinal chemistry. Literature has revealed that they possess a wide spectrum of biological activities including antimicrobial activity. Objective: The goal of this paper is the designing of new benzothiazole based thiazolidinones and the evaluation of their biological activities. Methods: The designed compounds were synthesized using classical organic synthesis methods. The antimicrobial activity was evaluated using the method of microdilution. Results: The twelve newly synthesized

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Dr., K. Chandra Sekhar M. S.* K. Sravana Lakshmi. "A Review Article on Recent Advances in The Pharmacological Diversification of Imidazole Derivatives." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 1581–99. https://doi.org/10.5281/zenodo.15205082.

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Furan a five membered aromatic heterocyclic ring system with O present at 1st position made up of 4C and4 H atoms furan ring is a part of many natural productslikeFurano flavonoid, furanocoumarins, etc... Furan nucleus show several biological applications and also shows strong affinity for a range of receptorsfuran and its derivatives are used in synthesis of many novel drugs. The antibacterial, antifungal, antiviral, anti-inflammatory, analgesic, anti-depressant, anti-anxiolytic, anti-Parkinson, anti-glaucoma, muscle-relaxant, anti-hypertensive, diuretics, anti-ulcer, anti-aging, anti-cancer,

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Sandhya, Paleri V., Chenam V. Bineesh, and Karickal R. Haridas. "Microwave assisted synthesis of substituted benzimidazoles using trimethylsilyl chloride as phase transfer catalyst, characterization, biological activities and molecular docking studies." Research Journal of Chemistry and Environment 26, no. 8 (2022): 119–26. http://dx.doi.org/10.25303/2608rjce1190126.

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A convenient method for the synthesis of imidazole derivatives using two phase system under microwave induced technique and phase transfer catalyst TMSCl (15%) is described. This technique has increased the rate of reaction drastically as well as the yield of the product when compared to conventional heating method. The synthesized compounds were screened for their in vitro antibacterial and antifungal activities against. The molecular docking studies were carried out using the software Arguslab 4.0.1. and minimum ligand pose energy of all the synthesized benzimidazoles, H-bond interactions an

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Sharma, Diksha, Archana Sharma, Rakesh Pahwa, Avtar Chand Rana, and Prabodh Chander Sharma. "Design, synthesis, anti-infective and anti-cancer potential of thiazole based Pyrazoles bearing benzothiazole moiety." Journal of medical pharmaceutical and allied sciences 11, no. 2 (2022): 4622–28. http://dx.doi.org/10.55522/jmpas.v11i2.2470.

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A new series of (E)-6-methyl-N-((3-phenyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-4-yl)methylene)benzo[d]thiazol-2-amine derivatives was developed. Structural investigation of the synthesized derivatives was carried out by several instrumental method of analysis like IR, and 1H-NMR spectroscopy. The titled analogues were examined for in-vitro anticancer and antiinfective activities. The biological findings specified that analogues 5a, 5b, 5d, 5e, 5f and 5g showed most potent antibacterial activity (MIC 62.5-250μg/mL) and 5a, 5e, 5f and 5g displayed most potent antifungal action (MIC 62.5-500 μg/mL

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El-Sharief, Marwa A. M. Sh, Samir Y. Abbas, Medhat A. Zahran, Yehia A. Mohamed, Ahmed Ragab, and Yousry A. Ammar. "New 1,3-diaryl-5-thioxo-imidazolidin-2,4-dione derivatives: synthesis, reactions and evaluation of antibacterial and antifungal activities." Zeitschrift für Naturforschung B 71, no. 8 (2016): 875–81. http://dx.doi.org/10.1515/znb-2016-0054.

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AbstractNew cyanothioformamide derivative 1 was prepared by treatment of 3,5-dichlorophenyl isothiocyanate with potassium cyanide at room temperature. Cycloaddition of cyanothioformamide 1 with phenyl isocyanate as electrophile furnished the corresponding imidazolidine 2. Imine hydrolysis of 2 with ethanolic HCl produced the corresponding 4-thioxo-2,5-imidazolidinedione 3. This compound was used as key synthon for the preparation of a wide variety of new substituted imidazole compounds. Condensation of 3 with different types of hydrazine derivatives furnished new series of hydrazone 4a, b, thi

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Pisal, Pooja, Meenakshi Deodhar, Amol Kale, Ganesh Nigade, and Smita Pawar. "DESIGN, SYNTHESIS, DOCKING STUDIES AND BIOLOGICAL EVALUATION OF 2-PHENYL-3-(SUBSTITUTED BENZO[d] THIAZOL-2-YLAMINO)-QUINAZOLINE-4(3H)-ONE DERIVATIVES AS ANTIMICROBIAL AGENTS." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 10 (2018): 57. http://dx.doi.org/10.22159/ijpps.2018v10i10.28480.

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Objective: A new series 2-phenyl-3-(substituted benzo[d] thiazol-2-ylamino)-quinazoline-4(3H)-one was prepared by the fusion method by reacting 2-phenyl benzoxazine with 2-hydrazino benzothiazole and it was evaluated for their antimicrobial activity against gram positive, gram negative bacteria and fungi.Methods: Titled compounds were synthesized by fusion reactions. These compounds were evaluated by in vitro antibacterial and antifungal activity using the minimum inhibitory concentration and zone of inhibition methods. The synthesized compounds were characterized with the help of infrared, NM

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Rossi, Renzo, and Maurizio Ciofalo. "Current Advances in the Synthesis and Biological Evaluation of Pharmacologically Relevant 1,2,4,5-Tetrasubstituted-1H-Imidazole Derivatives." Current Organic Chemistry 23, no. 19 (2019): 2016–101. http://dx.doi.org/10.2174/1385272823666191014154129.

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: In recent years, the synthesis and evaluation of the biological properties of 1,2,4,5-tetrasubstituted-1H-imidazole derivatives have been the subject of a large number of studies by academia and industry. In these studies it has been shown that this large and highly differentiated class of heteroarene derivatives includes high valuable compounds having important biological and pharmacological properties such as antibacterial, antifungal, anthelmintic, anti-inflammatory, anticancer, antiviral, antihypertensive, cholesterol-lowering, antifibrotic, antiuricemic, antidiabetic, antileishmanial an

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Chopra, Pratiksha N., and Jagdish K. Sahu. "Biological Significance of Imidazole-based Analogues in New Drug Development." Current Drug Discovery Technologies 17, no. 5 (2020): 574–84. http://dx.doi.org/10.2174/1570163816666190320123340.

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In the field of heterocyclic medicinal chemistry, especially five-membered ring structures containing a nitrogen atom, imidazole core is an imperative aromatic heterocycle which is usually present in naturally occurring products and synthetic bioactive molecules. The occurrence of imidazole moiety in therapeutic compounds may be beneficial in terms of improving water-soluble properties due to its two nitrogen atoms which leads to the creation of hydrogen bonds. The imidazole nucleus has also been recognized as an important isostere of triazole, pyrazole, thiazole, tetrazole, oxazole, amide etc

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Haque, M., Akash Marathakam, Ritesh Rana, et al. "Fighting Antibiotic Resistance: New Pyrimidine-Clubbed Benzimidazole Derivatives as Potential DHFR Inhibitors." Molecules 28, no. 2 (2023): 501. http://dx.doi.org/10.3390/molecules28020501.

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The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors. These compounds were filtered by using ADMET, drug-likeness characteristics calculations, and molecular docking experiments. Compounds 27, 29, 30, 33, 37, 38, and 41 were chosen for the synthesis based on the results of the in silico screening. Each of the synthesized compounds was tested for its in vitro antibacterial and antifungal activities using a variety of strains. All the compounds showed antibacterial properties against

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Chandni, Jain, Gopal Ram, Panwar Lalita, and Nagar Meena. "Phosphorylation and thiophosphorylation of 2-(4'-aminophenyl)-6-methyl benzothiazole and their biological activities." Journal of Indian Chemical Society 93, June 2016 (2016): 571–75. https://doi.org/10.5281/zenodo.5638395.

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Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India <em>E-mail</em> : nagar_meena@yahoo.com <em>Manuscript received online 15 December 2015, accepted 30 January 2016</em> Some novel organophosphorus compounds of the type [(C<sub>14</sub>H<sub>11</sub>N<sub>2</sub> S)<sub>n</sub>P(O)Cl<sub>3-n</sub>]/[(C<sub>14</sub>H<sub>11</sub>N<sub>2</sub> S)<sub>n</sub>P(S)Cl<sub>3-n</sub>] {where n=1–3} have been easily synthesized by the reaction of 2-(4'-aminophenyl)-6-methyl benzothiazole (C<sub>14</sub>H<sub>11</sub>N<sub>2</sub> S) with phosphorus oxychloride

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Artico, M., G. Stefancich, R. Silvestri та ін. "Research on antibacterial and antifungal agents. 16. Synthesis and antifungal activities of 1-[α-(1-naphthyl)benzyl]imidazole derivatives and related 2-naphthyl isomers". European Journal of Medicinal Chemistry 27, № 7 (1992): 693–99. http://dx.doi.org/10.1016/0223-5234(92)90089-j.

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Nishad, Ravi K., Karuna S. Shukla, and Pooja A. Chawla. "Design and Synthesis of 2-Substituted Benzothiazole Derivatives as Antioxidant and Antimicrobial Agents." Current Bioactive Compounds 16, no. 8 (2020): 1242–48. http://dx.doi.org/10.2174/1573407216666200128160438.

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Background: An upsurge in the number of antibiotic-resistant microbial infections has warranted the discovery and development of new antibiotics. This is a matter of great concern for effective therapy for a search of novel antimicrobial agents. Literature has a number of reports of involvement of oxidative stress due to an imbalance between the generation and neutralization of free radicals in many diseases. Heterocyclic compounds have been involved in the treatment of various disorders. Benzothiazole is one such heterocyclic nucleus having benzene ring merged with the thiazole ring. Among th

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Nirwan, N., C. Pareek, A. K. Chohadia, and K. K. Verma. "Synthesis, Antibacterial, and Antifungal Activities of 3-(4,5-Diphenyl-1<i>H</i>-Imidazol-2-yl)-1<i>H</i>-Indole Derivatives." Journal of Scientific Research 15, no. 1 (2023): 159–70. http://dx.doi.org/10.3329/jsr.v15i1.59004.

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Indolylimidazole ring-containing natural and synthesized compounds have shown vast biological activities. These indolylimidazole compounds contain both indole and imidazole rings. The indolylimidazole structure resembling compounds 1a-1d and 2a-2d were synthesized by a green and efficient one-pot four components condensation of indole-3-carbaldehyde, benzil, ammonium-acetate, and substituted amines under microwave irradiation using Amberlyst A-15 as a recyclable catalyst. The structures of synthesized compounds were characterized by FTIR, 1H NMR, and Mass spectrometric studies. These compounds

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ARTICO, M., G. STEFANCICH, R. SILVESTRI та ін. "ChemInform Abstract: Research on Antibacterial and Antifungal Agents. Part 16. Synthesis and Antifungal Activities of 1-(α-(1-Naphthyl)benzyl)imidazole Derivatives and Related 2-Naphthyl Isomers." ChemInform 24, № 13 (2010): no. http://dx.doi.org/10.1002/chin.199313190.

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