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Dissertations / Theses on the topic 'Imidazole Compounds'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Palamar, A. O. "Antimicrobial and antifungal activity of certain imidazole compounds." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18908.

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2

Ta, Hue Thu. "Reactions of 5-(3-alkyltriazeno)imidazole-4-carboxamide." Thesis, University of Newcastle Upon Tyne, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315657.

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3

Trnka, Michael J. "Photoaffinity labeling of cytochrome P450s with imidazole-tethered benzophenone compounds /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8516.

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4

Etogo, Anthony O. "Late transition metal chemistry of imidazole-based N-heterocyclic carbene ligands synthesis, characterization and luminescence /." abstract and full text PDF (free order & download UNR users only), 2006. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3209961.

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5

Moleko, Pulleng. "The coordination and extractive chemistry of the later 3d transition metal ions with N, N'-donor imidazole-based ligands." Thesis, Nelson Mandela Metropolitan University, 2014. http://hdl.handle.net/10948/8382.

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The application of bidentate N,N'-donor ligands, such as 2,2'-biimidazole (BIIMH2) and 2,2'-pyridylimidazole (PIMH) and (1H-benzimidazol-2yl)-N-methylmethanamine (BIMAH), in the solvent extraction of base metal ions from an acidic sulfate/sulfonate medium was investigated. PIMH and BIMAH showed selectivity for Ni(II) with the only interfering ion being Cu(II) in the pH range 1.2-1.8 but BIIMH2 lacked selectivity. The extraction patterns observed were influenced by stereochemical aspects, and this agreed well with the envisaged design of nickel(II)-specific extractants through stereochemical “t

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6

Banerjee, Kamalendu. "Reproductive performance and cocoon charecters of Bombyx mori L. with reference to regulated feeding and treatments with methoprene and imidazole compounds." Thesis, University of North Bengal, 1998. http://hdl.handle.net/123456789/1092.

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7

Milde, Bianca. "(Ethynyl-)Ferrocenyl Phosphine Palladium Complexes and (Bis-)Phosphinoimidazol(e/ium) Compounds and their Application in Homogeneous Catalysis." Doctoral thesis, Universitätsbibliothek Chemnitz, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-90521.

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Die vorliegende Dissertation beschäftigt sich mit der Synthese, der Charakterisierung und der Anwendung neuartiger Phosphane in homogenkatalytischen Reaktionen. Dabei wurden die Ferrocenyl- und Ferrocenylethinylphosphan-Palladium und Ferrocenylethinylphosphan-Ruthenium Komplexe in der Palladium-vermittelten Mizoroki-Heck- und Suzuki-Miyaura-Reaktion sowie der Ruthenium-katalysierten Synthese von β-Oxopropylestern verwendet. Der Schwerpunkt lag dabei auf der Untersuchung des Einflusses der elektronischen und räumlichen Eigenschaften der Phosphanliganden auf die Aktivität und Produktivität der e

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8

Arrué-Muñoz, Ramón. "Magnétisme coopératif dans des composés de coordination à base de Cu(II), Ni(II) et Co(II) et ligands imidazole carboxyliques." Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1S113/document.

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La présente thèse traite de la synthèse à température ambiante et pression atmosphérique de différents composés de coordination hybrides organique-inorganiques. La partie inorganique de ces composés est constituée d’éléments de transition de la première période 3dn divalents: cobalt, nickel et cuivre. Les ligands utilisés constituent la partie organique de ces composés. Les ligands employés sont l’acide-1H-imidazol-4-carboxilique (H2IMC) et l’acide-1H-imidazol-4,5-dicarboxílique (H3IMDC). La composante inorganique Mx+ est introduite dans le composé terminal en utilisant le précurseur métalliqu

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9

Björk, Malin. "Synthesis of sulfur and seleniumn heterocycles, including derivatives of imidazopyridine and benzimidazole /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-597-6/.

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10

Langlet, Abraham. "Nitration of Oxo-pyramidines and Oxo-imidazoles." Doctoral thesis, KTH, Kemi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-601.

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This thesis is mainly focused on the reactions of oxo-pyrimidines and oxo-imidazoles with nitric acid in sulfuric acid and properties of the gem-dinitro products formed in this process. Low temperature nitrations of 2-methylimidazoles produced – in addition to the known 2-methyl-5(4)-nitroimidazole – 2-(dinitromethylene)-5,5-dinitro-4-imidazolidinone and parabanic acid. This tetranitro compound was also obtained via nitration of 2-methyl-4,4-dihydro-(1H)-5- imidazolone. Thermal decomposition of 2-(dinitromethylene)-5,5-dinitro-4-imidazolidinone yielded 2-(dinitromethylene)-4,5-imidazolidinedio

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11

Appelskog, Ioulia. "Effects of imidazoline compounds on intracellular CA²⁺ and apoptosis /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4654-X.

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12

Brown, Colin A. "Studies on the interaction of imidazoline compounds with cells of the endocrine pancreas." Thesis, Keele University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359077.

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13

Guthrie, Kevin Mark. "Biophysical analysis of interaction of dihydro-imidazo-phenanthridinium based compounds with DNA." Thesis, University of Glasgow, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486740.

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The interaction of small molecules with DNA is an area ofresearch which is important to several fields, for example in anti-cancer and anti-viral drug design. However, the physical processes behind such molecular associations and their resultant biological activity are unclear. A thorough understanding ofthe underlying thermodynamics which govern such binding processes will aid in the design ofnew DNA binding ligands with enhanced properties. In this thesis the DNA binding properties ofa new class ofpotential intercalating agents, the dihydro-imidazo-phenathridinium (DIP) ligands, are discusse

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14

Oudot, Romain. "Synthèse de dérivés imidazo[1,2-a] pyridines et imidazo[1,2-b] pyridazines tricycliques." Thesis, Tours, 2009. http://www.theses.fr/2009TOUR3804.

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Les motifs imidazo[1,2-a]pyridines et imidazo[1,2-b]pyridazines sont des noyaux très étudiés par la communauté scientifique, notamment dans le domaine thérapeutique. Ceci s’explique en partie par les progrès récents réalisés dans le domaine de la métallocatalyse qui ont permis une fonctionnalisation plus simple de ces molécules. Cependant, les dérivés tricycliques de ces structures sont restés assez peu étudiés malgré le fait que certains de leurs isostères présentent des propriétés biologiques intéressantes. Les travaux de cette thèse ont porté sur deux projets distincts : -La synthèse d’imid

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15

Slough, Scott. "The effect of a novel series of imidazoline compounds on glucose homeostasis in the mouse." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340266.

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16

Angulo-Escalante, Miguel Angel 1962. "Inhibition of thioredoxin signalling by alkyl and aryl 2-imidazolyl disulfide compounds as potential antitumor agents." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282694.

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This work describes (1) the identification of alkyl and aryl 2-imidazolyl disulfides that inhibit growth in human cancer cell lines, (2) examines the antitumor activities of these disulfides in xenografted scid mice, (3) characterizes the chemopreventive activity in min mice of the disulfides IV-2, and (4) suggests the potential mechanisms by which these compounds mediate their actions. The alkyl and aryl 2-imidazolyl disulfides are inhibitors of the TR/Trx which regulates cell growth in both normal and cancer cells and is constitutively activated in a number of human primary cancers (Berggren

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17

Walmsley, Ryan Steven. "An investigation into the antidiabetic and catalytic properties of oxovanadium(IV) complexes." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1004978.

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In part 1 of this thesis, the antidiabetic activity of a series of novel oxovanadium(IV) complexes was investigated. A range of bidentate N,O-donor ligands, which partially mimic naturally occurring bioligands, were prepared and reacted with the vanadyl ion to form the corresponding bis-coordinated complexes. Initially, 2-(2ˊ-hydroxyphenyl)-1R-imidazoline (where R = H, ethyl and ethanol) ligands were prepared. The aqueous pH-metric chemical speciation was investigated using glass electrode potentiometry which allowed for the determination of protonation and stability constants of the ligands a

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18

Ierno, Hélène. "Modélisation chimique de protéines fer-soufre : synthèses et caractérisations physico-chimiques de nouveaux agrégats à ligands imidazoles." Université Joseph Fourier (Grenoble ; 1971-2015), 1995. http://www.theses.fr/1995GRE10151.

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Durant ces dernieres annees, de nombreuses proteines fer-soufre ont ete decouvertes dont le site actif est relie a l'apoproteine par des ligands non-cysteinyles ; elles presentent des proprietes spectroscopiques et electrochimiques particulieres, liees a la nature des acides amines impliques dans la coordination du cur fer-soufre. Pour modeliser la coordination d'histidines sur les centres fer-soufre, nous avons prepare des agregats a ligands imidazoles neutres. Notre demarche synthetique fait intervenir des centres fer-soufre deja formes, a ligands halogenures, sur lesquels nous realisons une

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19

Sayer, J. R. "The synthesis of imidazo[1,2-a]pyrazines as inhibitors of the VirB11 ATPase and their incorporation into bivalent compounds." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1398301/.

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Helicobacter pylori are gram negative bacteria that colonise in the human stomach causing illnesses such as peptide ulcers and various cancers. Through targeting a component of their secretion apparatus, it is envisaged that translocation of toxic molecules will be inhibited and therefore virulence would be reduced. Virtual high throughput screening of the Helicobacter pylori VirB11 ATPase, HP0525, identified imidazo[1,2-a]pyrazine compounds as potential ATP mimics and ATPase inhibitors. Synthesis of these target compounds was carried out, with two routes established to deliver 2- and 3- aryl

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20

Li, Jihui. "Copper-Catalyzed Domino C-N Bond Formation for Synthesis of N-Containing Compounds (Benzimidazoles, Imidazoles, and Guanidines) - Approach toward Total Synthesis of Natural Product Raputindoles." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112130.

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Cette thèse est constituée de trois parties : 1) Le contexte bibliographique, 2) le développement de réactions domino cupro-catalysées et 3) une approche vers la synthèse totale des raputindoles.La première partie introduit d’abord le concept de réactions domino ainsi que leurs applications, puis les réactions catalysées par du cuivre permettant de former des liaisons C-N sont passées en revue en incluant les couplages de Ullmann, Goldberg et de Chan-Lam, les séquences d’activation oxydante de liaisons C-H/formation de liaison C-N, l’insertion de nitrènes et l’hydroamination de liaisons C-C mu

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21

RAPETTI, FEDERICA. "New different catecholic and heterocyclic compounds able to interfere with different pathways in inflammation and cancer." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1083981.

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During my 3 years of PhD, I followed in parallel two projects: 1) synthesis of selective PDE4D3 inhibitors (PDE4Is), characterized by a substituted catechol scaffold, typical of Rolipram (pan-PDE4I), connected to an amino/amide tail through different linkers; 2) synthesis and biological evaluation of new compounds in which catechol moiety is connected to pyrazole and imidazo-pyrazole scaffolds through an acylhydrazonic linker to obtain potential anti-inflammatory and anticancer agents. In the 1st part of my PhD, I performed the chiral resolution of our lead GEBR-32a racemate, a PDE4D3I wit

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22

Heras, i. Corominas Montserrat. "Aproximacions sintètiques per a la preparació en dissolució i fase sòlida de llibreries de sistemes herocíclics de 5 membres amb elevada diversitat molecular. Síntesi d'imidazolones, triazoles i imidazoxazoles." Doctoral thesis, Universitat de Girona, 1999. http://hdl.handle.net/10803/96651.

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According to a strategy based on an Aza-Wittig reaction type, an efficient methodology in solution toward the synthesis of libraries of 2-aminoimidazolones with high molecular diversity has been developed. The strategy is readily adapted to the solid support. The regioselectivity in the heterocyclisation reaction between the corresponding carbodiimides and different primary amines for the synthesis of 2-aminoimidazolones has been studied. A correlation between the regioisomer obtained and the stereoelectronic properties of the primary amines used was stablished. The structural elucidation of t

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23

SCIANO', Fabio. "Development of natural and synthetic compounds as kinase inhibitors targeting cancer cells and cancer stem cells." Doctoral thesis, Università degli Studi di Palermo, 2023. https://hdl.handle.net/10447/580156.

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24

LI, PETRI Giovanna. "SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW IMIDAZO[2,1-b][1,3,4]THIADIAZOLE DERIVATIVES AS ANTICANCER AND ANTIBIOFILM AGENTS, AND PRECLINICAL INVESTIGATION OF ANTI-LDH-A COMPOUNDS AGAINST MALIGNANT MESOTHELIOMA." Doctoral thesis, Università degli Studi di Palermo, 2020. http://hdl.handle.net/10447/395253.

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25

Er-Rhaimini, Abderrahman. "Hétérocycles azotes N-benziles : synthèse de dérivés N-benziles de l'adénine : étude de la photoélimination de substituants benzyliques." Angers, 1986. http://www.theses.fr/1986ANGE0002.

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Synthèse des cinq N-(dimethoxy-3,5 benzyl) adénines. Photolyse de ces compose en solution aqueuse. Tentative de synthèse de l'(imidazo (1,2-a) pyridinyl-6methyl)-1 adénine. Ce travail montre que des substituants benzyliques photoéliminables peuvent être utilisés comme groupes protecteurs dans des synthèses mettant en jeu l'adénine et ses dérivés.

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26

RANDAZZO, Ornella. "DESIGN OF SF3B1 SUBUNIT MODULATORS OF THE SF3B SPLICEOSOME COMPLEX." Doctoral thesis, Università degli Studi di Palermo, 2022. http://hdl.handle.net/10447/533610.

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27

Sneddon, Scott. "Characterisation of inorganic materials using solid-state NMR spectroscopy." Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/8239.

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This thesis uses solid-state nuclear magnetic resonance (NMR) spectroscopy and density functional theory (DFT) calculations to study local structure and disorder in inorganic materials. Initial work concerns microporous aluminophosphate frameworks, where the importance of semi-empirical dispersion correction (SEDC) schemes in structural optimisation using DFT is evaluated. These schemes provide structures in better agreement with experimental diffraction measurements, but very similar NMR parameters are obtained for any structures where the atomic coordinates are optimised, owing to the simila

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28

Debleds, François. "Complexation d'électrophiles aromatiques par des bases hétérocycliques ambidentes : structure et réactivité d'adduits carbones et azotes pyrroliques indoliques et imidazoliques." Paris 6, 1987. http://www.theses.fr/1987PA066330.

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Structure et formation des complexes de Meisenheimer du trinitro-1,3,5 benzène avec divers indoles, pyrroles, imidazoles ; étude cinétique de la décomposition de ces complexes. Etude cinétique de la protonation du kryptopyrrole en solution aqueuse.

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29

Boukraa, Sadok. "Préparation, réactivité et étude des propriétés fongistatiques et immunostimulantes d'amino-2 thiazoles et d'imidazo-(2,1-B) thiazoles." Besançon, 1987. http://www.theses.fr/1987BESA2030.

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Le travail se divise en deux grandes parties : la premiere concerne la preparation d'aryl-6 imidazo(2,1-b) thiazoles substitues en 3 par des chaines de type acetate d'ethyle, aroylmethyle. (beta -hydroxy beta -aryl)ethyle te arylethyle. Pour ce faire, il a ete necessaire de preparer les amino-2 thiazoles corespondants substitues par ces memes chaines en 4 afin de las opposer a des acetophenones omega -bromees. L'influence des substituants presents est discutee en vue d'aprehender l'evolution des reactions. La seconde partie concerne des essais en tant que fongistatiques et/ou immunostimulants

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30

Yang, Cheng-Han, and 楊承翰. "Self-assembly, Structures, and Properties of Metal—Organic Compounds with Pyrimidine and Imidazole Ligands." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/64817776235120498736.

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碩士<br>國立中正大學<br>化學暨生物化學研究所<br>103<br>The goal of this study was to develop a self-assembly synthetic strategy for preparing coordination polymers using two ligands: orotic acid and urocanic acid. The synthetic method, structures and some properties of the products were investigated. Because both of these ligands contain carboxylate, imide and imidazole functional groups, respectively, they offer a very rich coordination chemistry. Thus, the numerous binding modes of the ligands can be expected to give rise to materials with drastically differing structures. The reaction of CaCl2•H2O with H2Or

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31

Cheng, Jack, and 鄭聖騫. "I. Crystal Structure Determination of nine imidazole compounds; II. Crystal Structure Determination of Agglutinin from Abrus precatorius." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/57397607254742780375.

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博士<br>國立清華大學<br>物理學系<br>97<br>In the first part, nine crystal structures of imidazole compounds have been determined by X-ray crystallography. Their coordination geometry and crystal packing are described. This part of work helped the author to be accustomed to crystallography. In the second part, the structure of agglutinin from Abrus precatorius has been determined by X-ray crystallography. The structure and the activity as a ribosome-inactivating protein (RIP) have been compared with abrin-a from Abrus precatorius. With docking study, ASN200 of abrin-a was found to be hydrogen bonded with G

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32

顏學仁. "Synthesis and biological activity of naphtho [ 2, 3-d] imidazole-4, 9-dione and its related compounds." Thesis, 1987. http://ndltd.ncl.edu.tw/handle/95205513988626943862.

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33

Gonzalez, Jorge Alberto. "Part I. Spin-state isomerism in crystalline (trifluoromethanesulfonato)(meso-tetraphenylporphinato)iron(III). Part II. Toward refined model compounds for the cytochrome c oxidase active site: A new picket-fence porphyrin with short imidazole pickets." Thesis, 1991. http://hdl.handle.net/1911/16443.

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Part I. The unsolvated porphyrin compound (Fe$\sp{\rm III}$(TPP)(OSO$\sb2$CF$\sb3$)) has been structurally characterized by single-crystal X-ray diffraction in a monoclinic phase at 293 K and in a triclinic phase at 293, 188 and 103 K. While only one type of molecular site is found in the monoclinic phase, the temperature-dependent structural parameters and magnetic susceptibility data (5.82 $\mu\sb{\rm B}$ at 293 K; 4.86 $\mu\sb{\rm B}$ at 20 K) together indicate the existence of two crystallographically and magnetically distinct spin-admixed crystal lattice sites in the triclinic phase. One

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34

"Half-sandwich group 4 metallacarborane monoamides and their application in synthesis of 2-aminoimidazoles." 2012. http://library.cuhk.edu.hk/record=b5894909.

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Wang, Yang.<br>"October 2011."<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2012.<br>Includes bibliographical references (leaves 87-92).<br>Abstracts in English and Chinese.<br>Acknowledgement --- p.I<br>Abstract (in English) --- p.III<br>Abstract (in Chinese) --- p.IV<br>Abbreviation --- p.V<br>List of Compounds --- p.VI<br>List of Figures --- p.IX<br>Contents --- p.X<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Synthesis and Structure of Half-Sandwich Group 4 Metallocarboranes Containing the Dicarbollyl Ligand --- p.2<br>Chapter 1.2 --- Half-Sandwich Gro

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35

Sun, Yu Shuang, and 孫瑀霜. "In vitro modulation of ABCG2 by AC1N5DA0 and a novel imidazole compound STK758118 with its derivatives." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/nnm32q.

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36

Tshivhase, Mmboneni Gifty. "Functionalised porphyrazines and their use in catalysis." Thesis, 2012. http://hdl.handle.net/10210/6024.

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D.Phil.<br>Porphyrazines like porphyrins and phthalocyanines have unique physical, chemical and spectral properties. This allows them to have many impressive applications. They are less studied than phthalocyanines because of the absence of convenient methods for their synthesis. However, recent studies, including this one, have made these compounds more accessible. The palladium-imidazolium salt systems have proved to be one of the most successful catalysts for the Heck and Suzuki coupling reactions. Substituents on nitrogen atoms of imidazolium significantly influence the catalytic activitie

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37

Almeida, Mário Rui Dias. "Synthesis of 5-aryl-imidazo [2,1-b] thiazole compounds possibly RAF kinase inhibitors." Master's thesis, 2014. http://hdl.handle.net/10451/38753.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>Malignant melanoma is the most aggressive type of skin cancer because of its high tendency to metastasize. In fact, the mortality rate from malignant melanoma has risen about 2% annually since 1960. Malignant melanoma occupies the 19th place as the most common cancer worldwide. In Portugal, according to the Portuguese League Against Cancer are nearly 700 new cases of melanoma annually and the incidence rate reaches 6-8 cases per 100000 individuals. These data are similar to Sou

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38

"Synthesis of novel benzimidazole derivatives and their platinum (II) complexes." Thesis, 2010. http://hdl.handle.net/10413/2614.

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Benzimidazole and its derivatives have attracted many organic chemists due to their interesting biological activities. These include activities against viruses such as, HIV, RNA, herpes (HSV-1), influenza, and cytomegalovirus (HCMV); antimicrobial and antitumor activities. Even though a lot of research has been conducted on the synthesis of benzimidazoles, factors such as, drug resistance present a need for synthesis of more structural analogues of these compounds. In chapter three, the synthesis of 2-aryl-1Hbenzimidazoles (46a-c) and 2-aryl-1-arylmethyl-1H-benzimidazoles (49a-d) is described.

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39

Ragie, Somayya. "The effect of novel compounds, imidazo [1,2-a] pyridines and azaindoles on colon cancer cell lines." Thesis, 2016. https://hdl.handle.net/10539/25793.

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40

Huang, Hsin-Yu, та 黃信裕. "Hypervalent Iodine(III) Compounds Mediated Syntheses of Imidazo[1,2-a]pyridines, α-Hydroxyketones, and α-Thiocyanatoketones". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/91995754284484662026.

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博士<br>高雄醫學大學<br>藥學研究所博士班<br>95<br>Recently, hypervalent iodine(III) compounds called green chemical reagents have been used extensively in organic synthesis due to their low toxicity, mild reactivity, easy handling, recovery and reused. As a continuation of our studies, we investigate organic syntheses by hypervalent iodine(III) compounds. Ionic liquids called green solvents have been used in many important studies of organic reaction due to their no flammability, no vapor and easy recovery. They which simultaneously serve as solvents as well as reagentants accelerate reaction to proceed. we

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41

TRULLI, LAURA. "Reactivity of trifluoromethyl aldimines with active methylene compounds." Doctoral thesis, 2016. http://hdl.handle.net/11573/924571.

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In this thesis the reactivity of N-protected trifluoromethyl (E)-aldimines towards different active methylene compounds in the Mannich-type and aza-Reformatsky reactions was studied. At first, suitable trifluoromethyl aldimines were reacted with β-dicarbonyl compounds, including diethyl malonate and several β-keto esters. The presence of a trifluoromethyl group, lowering both nitrogen basicity and carbon electrophilicity of the imine C=N group, greatly affects the Mannich-type addition of β-dicarbonyl compounds. In fact, the most common organic or inorganic bases, such as some organocatalysts

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42

Wu, Fang-Wen, and 吳芳文. "Hypervalent iodine (III) Compound Catalyzed Synthesis of Imidazo[2,1-b]thiazoles and Phenacyl Esters in PEG-400." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/80820307523264698552.

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碩士<br>高雄醫學大學<br>藥學研究所<br>99<br>Hypervalent iodine(III) compounds have been extensively used in organic syntheses due to their low toxicity, ready availability and easy handling. [Hydroxyl(tosyloxy)iodo]benzene (HTIB), phenyliodine(III) diacetate (PIDA) and phenyliodine(III) bis(trifluoroacetate) (PIFA) are the most frequently used and easily available reagents in the family of iodine compounds. Polyethylene glycols (PEG) are well-known to be inexpensive, recoverable, non-toxic, thermally stable, and biological compatible polymers. Polyethylene glycols are most commonly employed as a suppo

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Kurebwa, Taurai Flloyd. "The effect of imidazo [1,2-a] pyridine amines on MCF-7 and MDA-MB-231 breast cancer cells." Thesis, 2015. http://hdl.handle.net/10539/21597.

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A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in fulfillment of the requirements for the degree of Masters of Science in Medicine (Pharmacology) Johannesburg,2015<br>Breast cancer, is the most frequently diagnosed cancer in women and is associated with high mortality rates in South Africa. There is a high prevalence of metastatic breast cancer and triple negative tumours, which are associated with poor prognosis. In this study, the response of two breast cancer cell lines, MCF-7 and MDA-MB-231, were evaluated when treated with

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Wang, Ying-Lien, and 王櫻璉. "(I) The Design and Synthesis of Benzimidazole and Dihydroquinazolines Derivatives Based on Lead Compound (II) Ruthenium-Catalysed C-H activation to the Synthesis of [4,5]imidazo[2,1-a]isoindole Derivatives." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/71056344608467361199.

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