Log in

Relevant bibliographies by topics / Imidazole-dicarboxylic acid derivatives / Journal articles

To see the other types of publications on this topic, follow the link: Imidazole-dicarboxylic acid derivatives.

Journal articles on the topic 'Imidazole-dicarboxylic acid derivatives'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 23 journal articles for your research on the topic 'Imidazole-dicarboxylic acid derivatives.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Yakovleva, Ekaterina E., Eugeny R. Bychkov, Maria M. Brusina, Levon B. Piotrovsky, and Petr D. Shabanov. "Pharmacological activity of new imidazole-4,5-dicarboxylic acid derivatives in dopaminergic transmission suppression ttests in mice and rats." Research Results in Pharmacology 6, no. (4) (2020): 51–57. https://doi.org/10.3897/rrpharmacology.6.57883.

Full text

Abstract:

Objective: To study the antiparkinsonian activity of new 1,2-substituted imidazole-4,5-dicarboxylic acids in dopaminergic transmission suppression tests in mice and rats. Materials and methods: On a model of reserpine extrapyramidal disorders, the derivatives of imidazole-dicarboxylic acids (IEM2258, IEM2248, IEM2247) were injected into the lateral brain ventricles of the mice 30 minutes after injecting reserpine at the doses of 0.1–0.5 mmol. Locomotor activity was analyzed in the Open-field test 2 hours later. In the catalepsy model, the studied agents were injected, using a pre-implanted can

APA, Harvard, Vancouver, ISO, and other styles

2

Yasuda, Naohiko. "Synthesis of novel imidazole-4,5-dicarboxylic acid derivatives." Journal of Heterocyclic Chemistry 22, no. 2 (1985): 413–16. http://dx.doi.org/10.1002/jhet.5570220239.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Yakovleva, Ekaterina E., Eugeny R. Bychkov, Maria M. Brusina, Levon B. Piotrovsky, and Petr D. Shabanov. "Pharmacological activity of new imidazole-4,5-dicarboxylic acid derivatives in dopaminergic transmission suppression ttests in mice and rats." Research Results in Pharmacology 6, no. 4 (2020): 51–57. http://dx.doi.org/10.3897/rrpharmacology.6.57883.

Full text

Abstract:

Objective: To study the antiparkinsonian activity of new 1,2-substituted imidazole-4,5-dicarboxylic acids in dopaminergic transmission suppression tests in mice and rats. Materials and methods: On a model of reserpine extrapyramidal disorders, the derivatives of imidazole-dicarboxylic acids (IEM2258, IEM2248, IEM2247) were injected into the lateral brain ventricles of the mice 30 minutes after injecting reserpine at the doses of 0.1–0.5 mmol. Locomotor activity was analyzed in the Open-field test 2 hours later. In the catalepsy model, the studied agents were injected, using a pre-implanted can

APA, Harvard, Vancouver, ISO, and other styles

4

Khaliullin, Ferkat, Irina Nikitina, Irina Nikitina, et al. "SYNTHESIS AND ANTIDEPRESSANT ACTIVITY OF 2-BROMO-1-(THIETAN-3-YL) IMIDAZOLE-4, 5-DICARBOXYLIC ACID DERIVATIVES." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 8 (2017): 154. http://dx.doi.org/10.22159/ijpps.2017v9i8.17613.

Full text

Abstract:

Objective: Synthesis of the salts and diylidenehydrazidеs of 2-bromo-1-(thietan-3-yl) imidazole-4,5-dicarboxylic acid to evaluate the antidepressant activities.Methods: The structures of the synthesised compounds were confirmed by elemental analysis and 1Н NMR spectral data. The melting points of the compounds were determined on a Stuart SMP30 apparatus. The X-ray diffraction data for compound IIc were obtained at room temperature on a Xcalibur Gemini Еos. The antidepressant activity was investigated in the tail suspension and forced swimming tests. The locomotor activity and anxiety were stud

APA, Harvard, Vancouver, ISO, and other styles

5

Dergachev, V. D., E. E. Yakovleva, M. A. Brusina, E. R. Bychkov, L. B. Piotrovskiy, and P. D. Shabanov. "Antiparkinsonian activity of new N-methyl-D-aspartate receptor ligands in the arecoline hyperkinesis test." Meditsinskiy sovet = Medical Council, no. 12 (September 19, 2021): 406–12. http://dx.doi.org/10.21518/2079-701x-2021-12-406-412.

Full text

Abstract:

Introduction. Parkinson’s disease (PD) is one of the most common neurodegenerative diseases in the population of older patients. Even though long-term combination therapy helps to cope with the main manifestations of PD. It inevitably leads to the appearance of such side effects as drowsiness, hallucinations, dyskinesia, and many others. [12]. Therefore, the search for effective antiparkinsonian drugs devoid of the above-mentioned adverse reactions remains an urgent task of modern neuropharmacology.The explored substances are derivatives of imidazole-4,5-dicarboxylic acid. These compounds belo

APA, Harvard, Vancouver, ISO, and other styles

6

Liu, Yan-Ju, Di Cheng, Ya-Xue Li, Jun-Di Zhang, and Huai-Xia Yang. "A new one-dimensional CdII coordination polymer incorporating 2,2′-(1,2-phenylene)bis(1H-imidazole-4,5-dicarboxylate)." Acta Crystallographica Section C Structural Chemistry 74, no. 10 (2018): 1128–32. http://dx.doi.org/10.1107/s2053229618012603.

Full text

Abstract:

Imidazole-4,5-dicarboxylic acid (H3IDC) and its derivatives are widely used in the preparation of new coordination polymers owing to their versatile bridging coordination modes and potential hydrogen-bonding donors and acceptors. A new one-dimensional coordination polymer, namely catena-poly[[diaquacadmium(II)]-μ3-2,2′-(1,2-phenylene)bis(1H-imidazole-4,5-dicarboxylato)], [Cd(C16H6N4O8)0.5(H2O)2] n or [Cd(H2Phbidc)1/2(H2O)2] n , has been synthesized by the reaction of Cd(OAc)2·2H2O (OAc is acetate) with 2,2′-(1,2-phenylene)bis(1H-imidazole-4,5-dicarboxylic acid) (H6Phbidc) under solvothermal co

APA, Harvard, Vancouver, ISO, and other styles

7

Skoryna, D. Yu, O. Yu Voskoboinik, and S. I. Kovalenko. "Reactions of 1,4-NCCN-, 1,4-NNCN- and 1,5-NCCCN-binucleophiles with dicarboxylic acids cyclic anhydrides as a method of heterocyclic compounds synthesis (a review)." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 3 (June 2023): 29–53. http://dx.doi.org/10.32434/0321-4095-2023-148-3-29-53.

Full text

Abstract:

Critical analysis of published information related to the features of reaction of 1,4-NCCN-, 1,4-NNCN and 1,5-NCCCN-binucleophiles with cyclic anhydrides of dicarboxylic acids has been presented in the review. It has been shown that the reaction of named anhydrides with 1,4-NCCN-binucleophiles leads to the formation of the imidazole fragment that contains carboxyl-containing moiety. It has been shown that benzimidazole derivatives are among the most studied products of reaction between 1,4-NCCN- and cyclic anhydrides of dicarboxylic acids due to the high availability of initial compounds. The

APA, Harvard, Vancouver, ISO, and other styles

8

Iakovleva, E. E., M. A. Brusina, E. R. Bychkov, L. B. Piotrovsky, and P. D. Shabanov. "ANTIPARKINSONIAN ACTIVITY OF NEW LIGANDS OF THE GLUTAMATE NMDA-RECEPTOR COMPLEX - IMIDAZOLE-4,5-DICARBOXYLIC ACID DERIVATIVES." Вестник Смоленской государственной медицинской академии 19, no. 3 (2020): 41–47. http://dx.doi.org/10.37903/vsgma.2020.3.5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Baures, Paul W., Adam W. Caldwell, Chris R. Cashman, Marie T. Masse, Ethan B. Van Arnam, and Rebecca R. Conry. "The Influence by Substituents on the Intermolecular Hydrogen-Bonding Interactions in Imidazole-4,5-dicarboxylic Acid Derivatives." Crystal Growth & Design 6, no. 9 (2006): 2047–52. http://dx.doi.org/10.1021/cg060057i.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Baures, Paul W., Jeremy R. Rush, Alexander V. Wiznycia, John Desper, Brian A. Helfrich, and Alicia M. Beatty. "Intramolecular Hydrogen Bonding and Intermolecular Dimerization in the Crystal Structures of Imidazole-4,5-dicarboxylic Acid Derivatives." Crystal Growth & Design 2, no. 6 (2002): 653–64. http://dx.doi.org/10.1021/cg025549j.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Iljin, Victor V., Elena V. Litasova, Maksim S. Kvasov, Mariia A. Brusina, and Levon B. Piotrovskiy. "Evaluation of the bioavailability of 1H-imidazole-4,5-dicarboxylic acid derivatives using the calculated and experimental lipophilicity index of the molecule logP." Reviews on Clinical Pharmacology and Drug Therapy 20, no. 1 (2022): 55–60. http://dx.doi.org/10.17816/rcf20155-60.

Full text

Abstract:

BACKGROUND: It is important to know the ability of a substance to penetrate the cell membrane to assess the bioavailability of drugs. The distribution of matter between the organic phase and water can be used as a model of the distribution between the membrane and extracellular fluid, and can be expressed by a partion coefficient, called logP. AIM: The aim of this work was to determine the logP of 1H-imidazole-4,5-dicarboxylic acid (IDC) derivatives in various media and compare the values with theoretical ones. RESULTS: As a result of the work, the distribution coefficients of the

APA, Harvard, Vancouver, ISO, and other styles

12

Dergachev, Vladimir D., Ekaterina E. Yakovleva, Maria A. Brusina, Evgeny R. Bychkov, Levon B. Piotrovskiy, and Petr D. Shabanov. "Investigation of antiparkinsonian activity of new imidazole-4,5-dicarboxylic acid derivatives on the experimental model of catalepsy." Research Results in Pharmacology 9, no. 1 (2023): 41–47. http://dx.doi.org/10.18413/rrpharmacology.9.10006.

Full text

Abstract:

Introduction: To study the antiparkinsonian activity of new ligands of the glutamate NMDA receptor complex – 1,2–substituted imidazole-4,5-dicarboxylic acids – on an experimental model of catalepsy caused by haloperidolintraabdominal injections in rats. Materials and methods: The experiments were performed on Wistar rats weighing 300-350 g, obtained from the Rappolovo nursery of the Russian Academy of Medical Sciences (Leningrad Region). The animals were kept in standard plastic cages in vivarium conditions with free access to water and food at a temperature of 22±2 °C and in the experiment we

APA, Harvard, Vancouver, ISO, and other styles

13

Dergachev, Vladimir D., Ekaterina E. Yakovleva, Maria A. Brusina, Evgenii R. Bychkov, Levon B. Piotrovskiy, and Petr D. Shabanov. "Antidyskinetic activity of new derivatives of inydazol-4,5-dicarbonic acid in a parkinsonism experimental model due to administration of 6-hydroxydopapine." Psychopharmacology & biological narcology 14, no. 3 (2023): 161–68. http://dx.doi.org/10.17816/phbn567962.

Full text

Abstract:

BACKGROUND: Levodopa therapy currently remains the clinical method of choice for patients with Parkinsons disease. However, in the late stages of the disease, approximately 80% of patients receiving treatment developed levodopa-induced dyskinesia. The studied substances are derivatives of imidazole-4,5-dicarboxylic acid. Their pharmacological effect is produced due to interaction with the recognition site of NMDA receptor, which, together with their high efficiency, implies that they are safer than previously available drugs in this pharmacological group. AIM: To study the antidyskinetic

APA, Harvard, Vancouver, ISO, and other styles

14

Guo, Jun-Li, Guang-Yu Liu, Rui-Ying Wang, and Shu-Xiang Sun. "Synthesis and Structure Elucidation of Two Essential Metal Complexes: In-Vitro Studies of Their BSA/HSA-Binding Properties, Docking Simulations, and Anticancer Activities." Molecules 27, no. 6 (2022): 1886. http://dx.doi.org/10.3390/molecules27061886.

Full text

Abstract:

Imidazole and tetrazole derivatives are widely used as clinical drugs since they possess a variety of pharmaceutical function. Zinc and iron are essential trace elements of the human body, with less toxicity and good biocompatibility. In this paper, two new essential metal mononuclear complexes [M(H2tmidc)2(H2O)2]·2H2O (M = Zn (1), Fe (2)) were synthesized through the reaction of 2-((1H-tetrazol-1-yl)methylene)-1H-imidazole-4,5-dicarboxylic acid (H3tmidc) and ZnSO4·7H2O or FeSO4·7H2O. The crystal structures were determined by means of the X-ray single crystal diffraction technique. Results fro

APA, Harvard, Vancouver, ISO, and other styles

15

Jakovleva, Ekaterina E., Stanislav P. Foksha, Marija A. Brusina, et al. "Studying the anticonvulsive activity of new ligands of NDMA-receptor complex – imidazole-4,5-dicarbonic acid derivatives." Reviews on Clinical Pharmacology and Drug Therapy 18, no. 2 (2020): 149–54. http://dx.doi.org/10.17816/rcf182149-154.

Full text

Abstract:

NMDA receptors were proven to play a significant role in the processes of epileptogenesis. Experimental data indicate a significant anticonvulsant effect of NMDA receptor antagonists, but the use of the studied NMDA ligands remains limited due to their low efficiency and toxic effects. The aim of the study was to investigate the anticonvulsant effect of new ligands of the glutamate NMDA receptor complex imidazole-4,5-dicarboxylic acid (IDA) derivatives on a model of NMDA-induced convulsions in mice. The tested agents (IEM2258 and IEM2248) were injected into the lateral ventricles of a waking m

APA, Harvard, Vancouver, ISO, and other styles

16

Brusina, M. A., L. G. Kubarskaya, V. V. Iljin, D. N. Nikolaev, and L. B. Piotrovskiy. "DESIGN OF COMPOUNDS WITH ANTICONVULSANT ACTIVITY AMONG NMDA-RECEPTOR LIGANDS." Medical academic journal 19, no. 1S (2019): 225–26. http://dx.doi.org/10.17816/maj191s1225-226.

Full text

Abstract:

NMDA receptors play an important role in the development of immune responses. Therefore, the design of NMDAergic compounds presents great interest in various areas, including immunology. We have previously shown that some imidazole-4,5-dicarboxylic acid (IDA) derivatives are ligands of these receptors, and can exhibit both agonistic and antagonistic activities. In continuation of these studies and in attempt to establish the main structural parameters that determine the type of the activity, we developed a general method for synthesis of 1-, 2-mono and 1,2-disubstituted IDA derivatives. To est

APA, Harvard, Vancouver, ISO, and other styles

17

Piotrovskii, L. B., P. V. Lishko, A. P. Maksimyuk, I. Ya Aleksandrova, and O. A. Kryshtal'. "A new class of agonists and antagonists of N-methyl-D-aspartic acid receptors: Derivatives of imidazole-4,5- and pyrazole-3,4-dicarboxylic acids." Neuroscience and Behavioral Physiology 30, no. 5 (2000): 553–58. http://dx.doi.org/10.1007/bf02462614.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Dergachev, V., E. Iakovleva, M. Brusina, E. Bychkov, L. Piotrovskij, and P. Shabanov. "P.0439 Antiparkinsonian activity of new glutamate N-methyl-D-aspartate receptor ligands - imidazole-4, 5-dicarboxylic acid derivatives in the arecoline hyperkinesis test." European Neuropsychopharmacology 53 (December 2021): S319—S320. http://dx.doi.org/10.1016/j.euroneuro.2021.10.412.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Callear, Samantha K., and Michael B. Hursthouse. "The supramolecular assemblies of a selection of imidazole derivative and dicarboxylic acid salts." Acta Crystallographica Section A Foundations of Crystallography 65, a1 (2009): s252. http://dx.doi.org/10.1107/s0108767309094768.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Callear, Samantha K., Michael B. Hursthouse, and Terence L. Threlfall. "A systematic study of the crystallisation products of a series of dicarboxylic acids with imidazole derivatives." CrystEngComm 12, no. 3 (2010): 898–908. http://dx.doi.org/10.1039/b917191f.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Yuan, Gang, Chao Zhang, Yang-Yu Sun, Xiu-Mei Li, Xiao-Hui Yu, and Zhong-Min Su. "An europium complex assembled by a flexible derivative of imidazole-4,5-dicarboxylic acid as a fluorescence turn-off chemosensor to detect Cr(VI) anions." Inorganic Chemistry Communications 169 (November 2024): 113066. http://dx.doi.org/10.1016/j.inoche.2024.113066.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

YASUDA, N. "ChemInform Abstract: SYNTHESIS OF NOVEL IMIDAZOLE-4,5-DICARBOXYLIC ACID DERIVATIVES." Chemischer Informationsdienst 16, no. 48 (1985). http://dx.doi.org/10.1002/chin.198548185.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Yakovleva, Ekaterina, Mekhriniso Kamalova, Mariia Brusina, Evgenii Bychkov, Levon Piotrovskiy, and Petr Shabanov. "INVESTIGATION OF THE ANALGESIC ACTIVITY OF NEW LIGANDS OF THE NMDA RECEPTOR COMPLEX." Reviews on Clinical Pharmacology and Drug Therapy, June 4, 2024. http://dx.doi.org/10.17816/rcf624859.

Full text

Abstract:

According to the Russian Society for the Study of Pain, 90% of patients seeking medical help experience pain, with 70% suffering from chronic pain [15, 16]. It should be acknowledged that the capabilities of traditional analgesic methods are limited, and the prescription of opioids is associated with an increase in complications, the development of tolerance, drug dependence, and an increase in the patient's hospital stay costs. Thus, the main directions for improving pain relief include the rational combination of analgesics with different mechanisms of action and the development of new effec

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!