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Journal articles on the topic 'Imidazole – Toxicologie'

Author: Grafiati

Published: 4 June 2021

Last updated: 16 February 2022

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1

Raczak-Gutknecht, Joanna, Teresa Frąckowiak, Antoni Nasal, Anita Kornicka, Franciszek Sączewski, and Roman Kaliszan. "Are Alpha-2D Adrenoceptor Subtypes Involved in Rat Mydriasis Evoked by New Imidazoline Derivatives: Marsanidine and 7-Methylmarsanidine?" Dose-Response 15, no. 2 (2017): 155932581770121. http://dx.doi.org/10.1177/1559325817701213.

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The imidazoline compounds may produce mydriasis after systemic administration to some species (rats, cats, and mice). In mydriatic activity of imidazolines, α2D-adrenoceptors subtype(s) seems to be involved. In this study, the pupil dilatory effect evoked by 2 newly synthesized imidazoline derivatives—α2-adrenoceptor agonists: marsanidine and 7-methylmarsanidine—was compared. The compounds were tested alone as well as in the presence of α2-adrenoceptor antagonists (nonselective, yohimbine, and selective toward the following α2-adrenoceptor subtypes—α2A-2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-

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2

Sadek, Kamal Usef, Afaf Mohamed Abdel-Hameed, Hisham A. Abdelnabi, and Yasser Meleigy. "An efficient green synthesis of novel 1H-imidazo[1,2-a]imidazole-3-amine and imidazo[2,1-c][1,2,4]triazole-5-amine derivatives via Strecker reaction under controlled microwave heating." Green Processing and Synthesis 8, no. 1 (2019): 297–301. http://dx.doi.org/10.1515/gps-2018-0093.

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Abstract A highly efficient multi-component one-pot synthesis of novel 1H-imidazo[1,2-a]imidazole-3-amine and imidazo[2,1-c][1,2,4]triazole-5-amine derivatives has been developed through the reaction of easily available aromatic aldehydes, benzoyl cyanide and either 2-aminoimidazole-4,5-dicarbonitrile or 3-amino-1,2,4-triazole in pyridine under controlled microwave heating. The process is environmentally friendly, is operationally simple, with short reaction time and with high yields.

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3

Behjet, Shaimaa A., and Zahraa F. Khudair. "Synthesis and Characterization of Some New Heterocyclic Derivatives and Studying of their Biological Activity (Anti-Bacteria)." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 11, no. 01 (2020): 38–44. http://dx.doi.org/10.25258/ijpqa.11.1.6.

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Introduction: In this work synthesis, many kinds of heterocyclic derivatives by many steps, the first we preparation 1-(4-((1H-imidazol_2-yl-) diazenyl) phenyl) ethan-1_one. (1) by coupling of diazonium salt of p-amino acetophenone with imidazole in alkaline alcoholic media, the second step include react (1) with 2_amino_6_methylpyrimidin _4_ol in acid medium to get Schiff base derivatives(2)the last step include react(2) with (sodium azide, thioglycolic acid, glycine, alanine, Tryptophan, (2 aminobenzoic acid), (2-mercaptobenzoic acid) to give (tetrazole(3), thiazolidine(4), imidazolidine(5-7

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4

Tarnok, Zsuzsa, and Ivan Tarnok. "Histamine (HIS) degradation in microorganisms: Imidazole ring splitting and formation of imidazolyl ethanol (IMET) and imidazolyl acetic acid (IMAC) in mycobacteria." Agents and Actions 18, no. 1-2 (1986): 34–37. http://dx.doi.org/10.1007/bf01987975.

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5

Lowry, J. A., and J. T. Brown. "Significance of the imidazoline receptors in toxicology." Clinical Toxicology 52, no. 5 (2014): 454–69. http://dx.doi.org/10.3109/15563650.2014.898770.

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6

Yan Guo, Fang, Chang Ji Zheng, Meiyuan Wang, et al. "Synthesis and Antimicrobial Activity Evaluation of Imidazole‐Fused Imidazo[2,1‐ b ][1,3,4]thiadiazole Analogues." ChemMedChem 16, no. 15 (2021): 2354–65. http://dx.doi.org/10.1002/cmdc.202100122.

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7

Corell, Tim, and Gert Hasselmann. "Pharmacodynamics and Toxicology of Fenflumizole, a New Non-steroidal Anti-inflammatory Imidazole Derivative." Acta Pharmacologica et Toxicologica 53, no. 4 (2009): 288–96. http://dx.doi.org/10.1111/j.1600-0773.1983.tb03425.x.

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8

Ghasemi, Saeed, Simin Sharifi, and Javid Shahbazi Mojarrad. "Design, Synthesis and Biological Evaluation of Novel Piperazinone Derivatives as Cytotoxic Agents." Advanced Pharmaceutical Bulletin 10, no. 3 (2020): 423–29. http://dx.doi.org/10.34172/apb.2020.051.

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Purpose : In this study, a series of piperazin-2-one derivatives were prepared through bioisosteric substitution of the imidazole ring of L-778,123 (imidazole-containing FTase inhibitor) and rearrangement of groups based on the tipifarnib structure. Final compounds were evaluated for their cytotoxic activities on cancer and normal cell lines by MTT assay. Methods: Methyl α-bromophenylacetic acid and 1-(3-chlorophenyl) piperazin-2-one were synthesized using previously described methods. Methyl 2-(4-chlorophenyl)-2-(4-(3- chlorophenyl)-3-oxopiperazin-1-yl) acetate was prepared by reaction betwee

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9

Forster, R., S. D. Blowers, S. Cinelli, H. Marquardt, and J. Westendorf. "Mutagenicity testing of imidazole and related compounds." Mutation Research/Genetic Toxicology 298, no. 2 (1992): 71–79. http://dx.doi.org/10.1016/0165-1218(92)90031-t.

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10

Carballo, M. A., A. S. Hick, S. Soloneski, M. L. Larramendy, and M. D. Mudry. "Genotoxic and aneugenic properties of an imidazole derivative." Journal of Applied Toxicology 26, no. 4 (2006): 293–300. http://dx.doi.org/10.1002/jat.1132.

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11

Yan Guo, Fang, Chang Ji Zheng, Meiyuan Wang, et al. "Front Cover: Synthesis and Antimicrobial Activity Evaluation of Imidazole‐Fused Imidazo[2,1‐ b ][1,3,4]thiadiazole Analogues (15/2021)." ChemMedChem 16, no. 15 (2021): 2287. http://dx.doi.org/10.1002/cmdc.202100501.

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12

Mishra, Arun K., Arvind Kumar, Harpreet Singh, Shweta Verma, Jagdish K. Sahu, and Amrita Mishra. "Chemistry and Pharmacology of Luliconazole (Imidazole Derivative): A Novel Bioactive Compound to Treat Fungal Infection-A Mini Review." Current Bioactive Compounds 15, no. 6 (2020): 602–9. http://dx.doi.org/10.2174/1573407214666180717111419.

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Background: Currently, ringworm treatment drugs include two major categories: first, propylene amine drugs, such as terbinafine, butenafine and naftifine, which exert their bactericidal effects through inhibiting squalene cyclase, causing the lack of ergosterol and accumulation of squalene. The second category of imidazole drugs includes miconazole, econazole, clotrimazole, ketoconazole and bifonazole. Mechanism: These synthetic antifungal agents exhibits their action by inhibiting the lanosterol 14α- demethylation activity of fungal cell, leading to the prevention of the ergosterol synthesis

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13

Babizhayev, Mark A. "Designation of imidazole-containing dipeptides as pharmacological chaperones." Human & Experimental Toxicology 30, no. 7 (2010): 736–61. http://dx.doi.org/10.1177/0960327110377526.

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We review the dichotomous regulatory roles of natural imidazole-containing peptidomimetics (N-acetylcarnosine [NAC], carcinine, non-hydrolized carnosine) in maintaining skin homeostasis that determines whether keratinocytes survive or undergo apoptosis in response to various insults and in the development of skin diseases. General strategies addressing common ground techniques to improve absorption of usually active chaperone proteins or their dipeptide inducer (usually poorly absorbed) compounds include encapsulation into hydrophobic carriers, combination with penetration enhancers, active el

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14

Chetsanga, Christopher J., and Ignatius Mavunga. "Chemical reclosure of opened imidazole ring of guanine." Chemico-Biological Interactions 58 (1986): 117–23. http://dx.doi.org/10.1016/s0009-2797(86)80091-6.

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15

Abbas, Esraa R., Salih H. Kadhim, and Muneer A. Abbas AL-Da,amy. "Determination of Ni(II) in Alloy by Spectrophotometric method with anew chromogenic reagent (IDPBS)." International Journal of Pharmaceutical Quality Assurance 11, no. 01 (2013): 20–22. http://dx.doi.org/10.25258/ijpqa.11.1.14.

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A new chromogenic reagent 4-((imidazole-2-yl)diazenyl)-N-(pyrimidin-2-yl)benzenesulfonamide was synthesized by the reaction between imidazole and Sulphadiazine as azo reagent and used as new spectrophotometric method with highly sensitive to determined Nickel (II). The reagent reacts with nickel(II) in aqueous solution at pH= 7 to form dark- brown colored complex. The reagent and its complex were identified by Fourier transform infrared (FT-IR), Uv-visible,1HNMR, and 13CNMR spectroscopies and investigate the formula and charge of the prepared complex by molar ratio and molar conductivity measu

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16

Matsui, Hiroko, Yoko Sakanashi, Tomohiro M. Oyama, et al. "Imidazole antifungals, but not triazole antifungals, increase membrane Zn2+ permeability in rat thymocytes." Toxicology 248, no. 2-3 (2008): 142–50. http://dx.doi.org/10.1016/j.tox.2008.03.022.

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17

Babizhayev, Mark A. "The detox strategy in smoking comprising nutraceutical formulas of non-hydrolyzed carnosine or carcinine used to protect human health." Human & Experimental Toxicology 33, no. 3 (2013): 284–316. http://dx.doi.org/10.1177/0960327113493306.

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The increased oxidative stress in patients with smoking-associated disease, such as chronic obstructive pulmonary disease, is the result of an increased burden of inhaled oxidants as well as increased amounts of reactive oxygen species generated by various inflammatory, immune and epithelial cells of the airways. Nicotine sustains tobacco addiction, a major cause of disability and premature death. In addition to the neurochemical effects of nicotine, behavioural factors also affect the severity of nicotine withdrawal symptoms. For some people, the feel, smell and sight of a cigarette and the r

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18

Vlahakis, Jason Z., Mona N. Rahman, Gheorghe Roman, Zongchao Jia, Kanji Nakatsu, and Walter A. Szarek. "Rapid, convenient method for screening imidazole-containing compounds for heme oxygenase inhibition." Journal of Pharmacological and Toxicological Methods 63, no. 1 (2011): 79–88. http://dx.doi.org/10.1016/j.vascn.2010.05.015.

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19

Navas, José María, Antonio Chana, Bernardo Herradón, and Helmut Segner. "Induction of CYP1A by theN-imidazole derivative, 1-benzylimidazole." Environmental Toxicology and Chemistry 22, no. 4 (2003): 830–36. http://dx.doi.org/10.1002/etc.5620220422.

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20

Breider, Mike A., Herm M. Ulloa, David G. Pegg, and Alex W. Gough. "Nitro-Imidazole Radiosensitizer-Induced Toxicity in Cynomolgus Monkeys." Toxicologic Pathology 26, no. 5 (1998): 651–56. http://dx.doi.org/10.1177/019262339802600509.

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21

Regunathan, S., and D. J. Reis. "Imidazoline Receptors and Their Endogenous Ligands." Annual Review of Pharmacology and Toxicology 36, no. 1 (1996): 511–44. http://dx.doi.org/10.1146/annurev.pa.36.040196.002455.

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22

Michel, Martin C., and Paul A. Insel. "Are there multiple imidazoline binding sites?" Trends in Pharmacological Sciences 10, no. 9 (1989): 342–44. http://dx.doi.org/10.1016/0165-6147(89)90002-3.

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23

Bousquet, P. "Too early to subtype imidazoline receptors." Trends in Pharmacological Sciences 11, no. 1 (1990): 7. http://dx.doi.org/10.1016/0165-6147(90)90033-5.

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24

Medvetz, Doug A., Khadijah M. Hindi, Matthew J. Panzner, Andrew J. Ditto, Yang H. Yun, and Wiley J. Youngs. "Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole." Metal-Based Drugs 2008 (July 1, 2008): 1–7. http://dx.doi.org/10.1155/2008/384010.

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A class of Ag(I) N-heterocyclic carbene silver complexes, 1–3, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes 1–3 are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows 1 to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo.

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25

Lewis, D. F. V., A. D. Rodrigues, C. Ioannides, and D. V. Parke. "Adverse reactions of imidazole antifungal agents: Computer graphic studies of cytochrome P-450 interactions." Journal of Biochemical Toxicology 4, no. 4 (1989): 231–34. http://dx.doi.org/10.1002/jbt.2570040405.

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26

Cleary, John D., Jerry W. Taylor, and Stanley W. Chapman. "Imidazoles and Triazoles in Antifungal Therapy." DICP 24, no. 2 (1990): 148–52. http://dx.doi.org/10.1177/106002809002400207.

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27

Olivera, D. L., J. T. Laydon, L. Hillegass, A. M. Badger та J. C. Lee. "Effects of pyridinyl imidazole compounds on murine TNF-α production". Agents and Actions 39, S1 (1993): C55—C57. http://dx.doi.org/10.1007/bf01972719.

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28

Célariès, Benoît, Ghassoub Rima, Louis Court, Claude Lion, and Jean-Denis Laval. "Radioprotective Activity and Synthesis of Siladithioacetals and Germadithioacetals Derived from N-substituted Naphthylethylimidazoline." Metal-Based Drugs 8, no. 4 (2001): 199–210. http://dx.doi.org/10.1155/mbd.2001.199.

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A number of organosilicon and organogermanium derivatives and some related compounds including the N-substituted. 2-[1-naphthylmethyl]-2-imidazoline and 2-[1-(1-naphthyl)ethyl]-2-imidazoline have been prepared and the toxicity of some compounds have been determined in mice. In this paper we report the synthesis and the evaluation of the pharmacological activity of new organosilicon and organogermanium, compounds such as sila- and germadithioacetals derived from N-substituted naphthylimidazolne.

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29

Lee, C. S., Y. Hashimoto, K. Shudo, and M. Nagao. "Benzo-derivatives of mutagenic-carcinogenic 2-aminodipyrido[1,2-a:3′,2′-d]imidazole." Mutation Research/Environmental Mutagenesis and Related Subjects 147, no. 5 (1985): 264. http://dx.doi.org/10.1016/0165-1161(85)90089-5.

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30

Navas, José María, Antonio Chana, Bernardo Herradón, and Helmut Segner. "INDUCTION OF CYP1A BY THE N-IMIDAZOLE DERIVATIVE, 1-BENZYLIMIDAZOLE." Environmental Toxicology and Chemistry 22, no. 4 (2003): 830. http://dx.doi.org/10.1897/1551-5028(2003)022<0830:iocbtn>2.0.co;2.

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31

Menegola, Elena, Maria L. Broccia, Francesca Di Renzo, and Erminio Giavini. "Dysmorphogenic effects of some fungicides derived from the imidazole on rat embryos cultured in vitro." Reproductive Toxicology 21, no. 1 (2006): 74–82. http://dx.doi.org/10.1016/j.reprotox.2005.07.008.

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32

Bickmeyer, Ulf, Achim Grube, Karl-Walter Klings, and Matthias Köck. "Disturbance of voltage-induced cellular calcium entry by marine dimeric and tetrameric pyrrole–imidazole alkaloids." Toxicon 50, no. 4 (2007): 490–97. http://dx.doi.org/10.1016/j.toxicon.2007.04.015.

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33

Laignelet, Laurence, Jean-Francois Narbonne, Jean-Claude Lhuguenot, and Jean-Louis Riviere. "Induction and inhibition of rat liver cytochrome(s) P-450 by an imidazole fungicide (prochloraz)." Toxicology 59, no. 3 (1989): 271–84. http://dx.doi.org/10.1016/0300-483x(89)90197-2.

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34

Sjaastad, Ø. V., and Ottar Sjaastad. "Rupture of the Imidazole Ring of Histamine and N-Acetylhistamine by Human Intestinal Contents." Acta Pharmacologica et Toxicologica 30, no. 5-6 (2009): 366–71. http://dx.doi.org/10.1111/j.1600-0773.1972.tb00668.x.

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35

Ghusoon Jawad Shabaa. "Cloud point extraction for separation, preconcentration and determination zinc (ii) in different pharmaceutical samples." International Journal of Research in Pharmaceutical Sciences 10, no. 4 (2019): 3006–12. http://dx.doi.org/10.26452/ijrps.v10i4.1587.

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Joining solvent extraction with cloud point extraction methods obtained a susceptible method for separation, pre-concentration, extraction and categorization of Zn (II), after forming an ion-pair association complex between Zn+2 and 4-(3-methyl phenyl azo)-4,5- diphenyl imidazole (MPADPI) with wavelength for maximum absorbance λmax.=496 Nm. This study shows optimum conditions for the formation and exaction ion-pair association complex under pH=9 and 0.5 mL Tritonx-100, 1×10-4 M (MPADPI) and heating at 80 Co for 20 minutes so that this study involved the effect of electrolyte and interferences

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36

Vodička, Pavel, and Kari Hemminki. "Depurination and imidazole ring-opening in nucleosides and DNA alkylated by styrene oxide." Chemico-Biological Interactions 68, no. 1-2 (1988): 117–26. http://dx.doi.org/10.1016/0009-2797(88)90010-5.

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37

Onderwater, Rob C. A., Jan N. M. Commandeur, and Nico P. E. Vermeulen. "Comparative cytotoxicity of N-substituted N′-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices." Toxicology 197, no. 2 (2004): 80–90. http://dx.doi.org/10.1016/j.tox.2003.11.014.

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38

Gómez-Ríos, David, Howard Ramírez-Malule, Peter Neubauer, Stefan Junne, and Rigoberto Ríos-Estepa. "Degradation Kinetics of Clavulanic Acid in Fermentation Broths at Low Temperatures." Antibiotics 8, no. 1 (2019): 6. http://dx.doi.org/10.3390/antibiotics8010006.

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Clavulanic acid (CA) is a β-lactam antibiotic inhibitor of β-lactamase enzymes, which confers resistance to bacteria against several antibiotics. CA is produced in submerged cultures by the filamentous Gram-positive bacterium Streptomyces clavuligerus; yield and downstream process are compromised by a degradation phenomenon, which is not yet completely elucidated. In this contribution, a study of degradation kinetics of CA at low temperatures (−80, −20, 4, and 25 °C) and pH 6.8 in chemically-defined fermentation broths is presented. Samples of CA in the fermentation broths showed a fast declin

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39

Aktar, Md, Dwaipayan Sengupta, Swarnali Purkait, Madhumita Ganguly, and M. Paramasivam. "Degradation dynamics and dissipation kinetics of an imidazole fungicide (Prochloraz) in aqueous medium of varying pH." Interdisciplinary Toxicology 1, no. 3-4 (2008): 203–5. http://dx.doi.org/10.2478/v10102-010-0047-6.

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Degradation dynamics and dissipation kinetics of an imidazole fungicide (Prochloraz) in aqueous medium of varying pHLaboratory degradation studies were performed in water at pH 4.0, 7.0 and 9.2 using Prochloraz (450 EC) formulation at the concentration of 1.0 (T1) and 2.0 (T2) μg/mL. Water samples collected on 0 (2 h), 3, 7, 15, 30, 45, 60 and 90 days after treatments were processed for residue analysis of Prochloraz by HPLC-UV detector. In 60 days, dissipation was 89.1-90.5% at pH 4.0, 84.1-88.2% at pH 7.0, and 92.4-93.8% at pH 9.2 in both treatments. The results indicate that at pH 7.0 the d

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40

Needham, D., and I. R. Challis. "The metabolism and excretion of prochloraz, an imidazole-based fungicide, in the rat." Xenobiotica 21, no. 11 (1991): 1473–82. http://dx.doi.org/10.3109/00498259109044397.

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41

Corell, Tim, Karen Meller Jensen, and Jacek Splawinski. "A New Anti-inflammatory Derivative of Imidazole which is Less Ulcerogenic than Indomethacin in Rats." Acta Pharmacologica et Toxicologica 45, no. 3 (2009): 232–39. http://dx.doi.org/10.1111/j.1600-0773.1979.tb02387.x.

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42

Laignelet, L., J. L. Rivière, and J. C. Lhuguenot. "Metabolism of an imidazole fungicide (prochloraz) in the rat after oral administration." Food and Chemical Toxicology 30, no. 7 (1992): 575–83. http://dx.doi.org/10.1016/0278-6915(92)90191-m.

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43

Ferrari, F., A. Tampieri, and V. Mangiafico. "Imidazole modification of aggressive behaviour in rats and mice." Life Sciences 40, no. 24 (1987): 2343–49. http://dx.doi.org/10.1016/0024-3205(87)90508-x.

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44

Onderwater, R. C. A., A. E. Rettie, J. N. M. Commandeur, and N. P. E. Vermeulen. "Bioactivation of N-substituted N′-(4-imidazole-ethyl)thioureas by human FMO1 and FMO3." Xenobiotica 36, no. 7 (2006): 645–57. http://dx.doi.org/10.1080/00498250500354329.

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45

HIRAYAMA, TERUHISA, YASUO MORI, JUNKO KANDA, et al. "Scavenged Effects of Cu(II) Chelates of Imidazole and Thiazole Derivatives on the Active Oxygen Species in vitro." Eisei kagaku 39, no. 1 (1993): 56–62. http://dx.doi.org/10.1248/jhs1956.39.56.

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46

Khay, Sathya, A. M. Abd EI-Aty, Jeong-Heui Choi, and Jae-Han Shim. "Analysis of Residual Triflumizole, an Imidazole Fungicide, in Apples, Pears and Cucumbers Using High Performance Liquid Chromatography." Toxicological Research 24, no. 1 (2008): 87–91. http://dx.doi.org/10.5487/tr.2008.24.1.087.

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47

Hamzeh-Mivehroud, Maryam, Zoha Khoshravan-Azar, and Siavoush Dastmalchi. "QSAR and Molecular Docking Studies on Non-Imidazole-Based Histamine H3 Receptor Antagonists." Pharmaceutical Sciences 26, no. 2 (2020): 165–74. http://dx.doi.org/10.34172/ps.2019.64.

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Background: In the recent years, histamine H3 receptor (H3R) has been receiving increasing attention in pharmacotherapy of neurological disorders. The aim of the current study was to investigate structural requirements for the prediction of H3 antagonistic activity using quantitative structure-activity relationship (QSAR) and molecular docking techniques. Methods: To this end, genetic algorithm coupled partial least square and stepwise multiple linear regression methods were employed for developing a QSAR model. The obtained QSAR model was stringently assessed using different validation criter

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48

Ishikawa, T., Y. Kamisaki, and T. Itoh. "Pharmacological properties of the hydroxylated histamine, (±)-4(5)-(2-amino-1-hydroxyethyl)-imidazole." Agents and Actions 26, no. 3-4 (1989): 261–66. http://dx.doi.org/10.1007/bf01967288.

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49

Babín, M., S. Casado, A. Chana, et al. "Cytochrome P4501A induction caused by the imidazole derivative Prochloraz in a rainbow trout cell line." Toxicology in Vitro 19, no. 7 (2005): 899–902. http://dx.doi.org/10.1016/j.tiv.2005.06.037.

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50

Sharma, Rahul, Kapil Upadhyaya, Bhanushree Gupta, et al. "Glycosylated-imidazole aldoximes as reactivators of pesticides inhibited AChE: Synthesis and in-vitro reactivation study." Environmental Toxicology and Pharmacology 80 (November 2020): 103454. http://dx.doi.org/10.1016/j.etap.2020.103454.

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