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1

A, Hamilton C., Prichard B. N. C, Zwieten P. A. van, and Royal Society of Medicine Services (Great Britain), eds. The I₁-imidazoline receptor agonist moxonidine: A new antihypertensive. Royal Society of Medicine Services Limited, 1994.

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2

van, Zwieten P. A., ed. The I[subscript 1]-imidazoline receptor agonist moxonidine: A new antihypertensive. 2nd ed. Royal Society of Medicine, 1996.

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3

J, Reis Donald, Bousquet Pascal, Parini Angelo, and International Symposium on Imidazoline Receptors (2nd : 1994 : New York, N.Y.), eds. The imidazoline receptor: Pharmacology, functions, ligands, and relevance to biology and medicine. New York Academy of Sciences, 1995.

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4

Ibbotson, Timothy. The imidazoline/guanidine receptor site and its role in potassium channel moulation in vascular smooth muscle. University of Manchester, 1993.

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5

Playford, Martin P. The role of the type 1 insulin-like growth factor receptor in cancer biology. Oxford Brookes University, 2000.

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6

Johansson, P. J. Hugo. Herpes simplex virus type 1 induced IgG Fc receptor: Aspects of specificity and function. Univ., 1989.

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7

1929-, Shigeta Yukio, Kobayashi Masashi Dr, and Olefsky Jerrold M, eds. Recent advances in insulin action and its disorders: Proceedings of the International Symposium on Insulin Action and Its Disorders, Shiga, 16 May 1990. Excerpta Medica, 1991.

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8

Flavin, Nora. Cloning and characterisation of the bovine activin receptor type II gene (ActRII): Its localisation to chromosome 2 (BTA2) by somatic cell genetic analysis and the genotyping of an associated microsatelltie UCD2. University College Dublin, 1996.

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9

P.A.Van Zwieten (Editor), C. A. Hamilton (Editor), B.N.C. Prichard (Editor), and S. Julius (Editor), eds. The I1-Imidazoline Receptor Agonist Moxonidine. 2nd ed. Royal Society of Medicine Press Ltd, 1996.

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10

P.A.Van Zwieten (Editor), C. A. Hamilton (Editor), and B.N.C. Prichard (Editor), eds. The I1-Imidazoline Receptor Agonist Moxonidine. Royal Society of Medicine Press Ltd, 1994.

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11

Kumaran, Jyothi. Type I interferon receptor interactions. 2005.

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12

N. Y.) International Symposium on Imidazoline Receptors 1994 (New York. The Imidazoline Receptor: Pharmacology, Functions, Ligands, and Relevance to Biology and Medicine (Annals of the New York Academy of Sciences). New York Academy of Sciences, 1995.

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13

The Imidazoline Receptor: Pharmacology, Functions, Ligands, and Relevance to Biology and Medicine (Annals of the New York Academy of Sciences, V. 763). New York Academy of Sciences, 1995.

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14

Eshleman, Amy J. Pyrethroid insecticide interaction with the GABAA receptor and the peripheral-type benzodiazepine receptor of rainbow trout brain. 1990.

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15

Phosphoinositidase C-Linked Receptor Desenisitization. Ray Langley, 1996.

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16

Abood, Mary E., and Thomas Gamage. The cloning and characterization of the cannabinoid type 1 receptor. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0025.

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The cloning and characterization of the first cannabinoid receptor (now known as the cannabinoid type 1 (CB1) receptor) by Matsuda et al. in the landmark paper discussed in this chapter was a seminal discovery in 1990. While the analgesic properties of marijuana had been known for thousands of years, the mechanisms through which marijuana produces analgesia were not understood. The identification and functional characterization of the CB1 receptor led to the discovery of an endogenous cannabinoid system (the endocannabinoid system), which has now been shown to be important not only for acute a
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17

Chun, Denise Karin. Regulators of AMPA-type glutamate receptor trafficking in Caenorhabditis elegans. 2008.

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18

Volkova, Yulia, Tatyana Tihonova, and Igor Zavarzin. Modern trends in the development of gamma-aminobutyric acid type A receptor modulators. LCC MAKS Press, 2022. http://dx.doi.org/10.29003/m3034.978-5-317-06826-4.

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Γ-Aminobutyric acid type A receptors (GABAARs) are among the vital biological targets that regulate the key processes of the central nervous system and human mental health: learning and memory formation processes, wakefulness and sleep. Modulators of GABAARs are widely used as anticonvulsants, anesthetics, antidepressants, sleeping medicine and anti-anxiety drugs. This monograph is the first systematic analysis of the literature data on the search for novel GABAARs-specific modulators of synthetic origin in the last ten years. The monograph is addressed to a wide range of specialists in the fi
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19

Demetriou, Michael. Protein antagonists of TGF-[beta] that mimic the type II TGF-[beta] receptor. 1995.

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20

Interaction of varicella-zoster virus with cells: Entry and exit. 1994.

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21

Liu, Jeh-Ping. Mouse mutants carrying a targeted disruption of the gene encoding the type-1 insulin-like growth factor receptor. 1993.

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22

Zürich, Eidgenössische Technische Hochschule, ed. The bone morphogenetic protein type II receptor is induced by type-I collagen in endothelial cells and up-regulated in an in vivo angiogenesis model. 1999.

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23

Rainey, Susan. Cloning and characterization of the insulin receptor-related receptor (IRR) reveals that it is closely associated with trkA in the genome and maps to human chromosome 1q22, A type 2 diabetes susceptibility locus. 2002.

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24

Complement Receptor Type 1(Cr1) on Human Erythrocytes: Functional Studies With Particular Reference to the Interaction With Complement Opsonized Immune Complexes. Univ Pr of Southern Denmark, 1992.

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25

Pece-Barbara, Nadia. Endoglin is an accessory protein of multiple signalling receptor complexes of the TGF-[beta] superfamily: Implications on the development of hereditary hemorrhagic telangiectasia type 1 (HHT1). 1999.

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26

Lorent, Kristin. Expression of the Alpha-2-Macroglobulin Receptor System and the Amyloid Precursor Protein Family in Embryos and in Adult Brain of Wild Type and transg: Enic Mice (Acta Biomedica Lovaniensia , No 148). Coronet Books Inc, 1997.

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27

Desroches, Julie. Peripheral analgesia involves cannabinoid receptors. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0034.

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This landmark paper by Agarwal and colleagues was published in 2007, when the exact contribution of the activation of the cannabinoid type 1 receptor (CB1) receptors expressed on the peripheral terminals of nociceptors in pain modulation was still uncertain. At that time, while it was clearly demonstrated that the central nervous system (CNS) was involved in the antinociceptive effects induced by the activation of the CB1 receptor, many strains of mice in which the gene encoding the CB1 receptor was deleted by conditional mutagenesis were used to study the specific role of these receptors in p
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28

Burton, Derek, and Margaret Burton. Perception and sensation. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198785552.003.0012.

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Major features of tetrapod sensory structures are well developed in fish which also have lateral lines, and some have electroreceptors and possibly magnetoreceptors. Receptors may be categorized according to the type of stimulus to which they respond: photoreceptors, chemoreceptors, mechanoreceptors, temperature receptors and nociceptors. Adaptations to aquatic habitats are described for examples from each category. Each type of receptor has the capacity to transduce (transform) its specific sensory stimulus into receptor potentials which initiate or modulate activity in sensory neurons to the
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29

Nielsen, David A., Dmitri Proudnikov, and Mary Jeanne Kreek. The Genetics of Impulsivity. Edited by Jon E. Grant and Marc N. Potenza. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780195389715.013.0080.

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Impulsivity is a complex trait that varies across healthy individuals, although when excessive, it is generally regarded as dysfunctional. Impulsive behavior may lead to initiation of drug addiction that interferes with inhibitory controls, which may in turn result in facilitation of the individual’s impulsive acts. Although environmental factors play a considerable role in impulsive behavior, a body of evidence collected in twin studies suggests that about 45% of the variance in impulsivity is accounted for by genetic factors. Genetic variants studied in association with impulsivity include t
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30

Rao, Shilpa, and Jerrold Lerman. Postoperative Nausea and Vomiting in Patients with Prolonged QTc. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199764495.003.0070.

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A panoply of pharmacological and nonpharmacological strategies are currently employed to attenuate the risk of postoperative nausea and vomiting (PONV) in children, including 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists. 5-HT3 receptor antagonists can prolong the QT interval, which can be a precursor of torsades de pointes (TdP), particularly in children with congenital or acquired prolonged QT interval. This chapter summarizes the causes of prolonged QT interval, the potential interactions of prolonged QT interval with antiemetics and anesthetics, and strategies to prevent PONV.
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31

Hughes, Jim. Exposures and image quality. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198813170.003.0004.

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In C-arm systems, the X-ray beam output is determined by both the signal returned from the automatic exposure device (AED) in the receptor and the exposure table set up for the exam type. The settings for the exposure (as well as aspects of the image receptor and display) will affect the qualities or resolutions of the resulting image. This chapter covers the factors and qualities of images produced by an X-ray C-arm system, and the effect that varying exposure factors has on the resulting image quality and resolutions. This includes spatial, temporal, and contrast resolutions, as well as the
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32

Hohmann, Andrea G. Control of pain initiation by endogenous cannabinoids. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0033.

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The landmark paper discussed in this chapter, published by Calignano et al. in 1998, focuses on the control of pain initiation by endogenous cannabinoids. In the paper, analgesic lipid mediators are shown to be present in peripheral paw tissue where they control the ability of pain signals to ascend to the central nervous system (CNS). Anandamide acts through a peripheral mechanism to suppress inflammatory pain via cannabinoid type 1 receptors. Palmitoylethanolamine, subsequently identified as an endogenous ligand for peroxisome proliferator-activated receptor-α‎, produces peripheral antinocic
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33

Fox, Susan H. Delayed and Often Persistent. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190607555.003.0021.

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Tardive syndromes are drug-induced hyperkinetic movement disorders that occur as a consequence of dopamine D2 receptor antagonism/blockade. There are several types, including classical tardive dyskinesia, tardive dystonia, tardive tics, tardive myoclonus, and tardive tremor, and it is important to the management of these disorders that the type of movement disorder induced is identified. Tardive syndromes can occur with all antipsychotic drugs, including so-called atypical drugs. Patients taking these drugs should be evaluated frequently for side effects. Evaluating the nature of the movement
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34

Dilsizian, Vasken, Ines Valenta, and Thomas H. Schindler. Myocardial Viability Assessment. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199392094.003.0021.

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Heart failure may be a consequence of ischemic or non-ischemic cardiomyopathy. Etiologies for LV systolic dysfunction in ischemic cardiomyopathy include; 1) transmural scar, 2) nontransmural scar, 3) repetitive myocardial stunning, 4) hibernating myocardium, and 5) remodeled myocardium. The LV remodeling process, which is activated by the renin-angiotensin system (RAS), stimulates toxic catecholamine actions and matrix metalloproteinases, resulting in maladaptive cellular and molecular alterations5, with a final pathway to interstitial fibrosis. These responses to LV dysfunction and interstiti
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35

Cattran, Daniel C., and Heather N. Reich. Membranous glomerulonephritis. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0064_update_001.

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It has been clear for several decades from comparison with the rodent model disease Heymann nephritis that membranous glomerulonephritis (MGN) is an immune condition in which antibodies, usually autoantibodies, bind to targets on the surface of podocytes. However, the antigen in Heymann nephritis, megalin, is not present on human podocytes. The first potential antigen was identified by studying rare examples of maternal alloimmunization, leading to congenital membranous nephropathy in the infant caused by antibodies to neutral endopeptidase. More recently, the target of autoantibody formation
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36

Paneni, Francesco, and Massimo Volpe. Co-morbidity (HFrEF and HFpEF): hypertension. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198784906.003.0415_update_001.

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Hypertensive heart disease is a major cause of heart failure (HF) and mortality. Hypertension precedes HF occurrence in 75% of cases, and carries a sixfold increase in HF risk as compared to non-hypertensive individuals. Most importantly, a minority of patients survive 5 years after the onset of hypertensive HF. In hypertensive patients, the heart may present different patterns of adaptive remodelling: concentric remodelling, concentric hypertrophy, and eccentric hypertrophy. Although most hypertensive patients are at high risk of developing concentric hypertrophy, a growing proportion of subj
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37

Gnudi, Luigi, Giorgio Gentile, and Piero Ruggenenti. The patient with diabetes mellitus. Edited by Giuseppe Remuzzi. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0149_update_001.

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About one third of patients with type 1 diabetes develop diabetic nephropathy long-term (usually not before at least 10 years of diabetes), though this proportion is falling as standards of care have risen. Nephropathy is strongly associated with other microvascular complications of diabetes, so that some degree of retinopathy is to be expected, and evidence of neuropathy is common. Patients with type 2 diabetes are equally susceptible, but this is an older group in which vascular disease and other pathologies are also more likely. The rise in type 2 diabetes accounts for diabetes being the mo
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