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Dissertations / Theses on the topic 'Imidazoline receptor type I'

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Published: 4 June 2025

Last updated: 1 August 2025

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1

Sun, Zheng. "IMIDAZOLINE RECEPTORS IN INSULIN SIGNALING AND METABOLIC REGULATION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1157694260.

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2

Verdun, Antoine. "Détection et dosage d'une substance endogène de type imidazoline : approche immunologique et hypothèses physio-pathologiques." Université Louis Pasteur (Strasbourg) (1971-2008), 1992. http://www.theses.fr/1992STR1M201.

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3

Pirnat, Deni. "The importance of the renal sympathetic nerves in the natriuretic response to imidazoline receptor agonists." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ62822.pdf.

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4

Mueller, Heather. "Depressor and diuretic effects of imidazoline receptor stimulation in the paraventricular nucleus of the hypothalamus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0007/MQ41750.pdf.

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5

Kawamoto, Shuji. "Bidirectional effects of dexmedetomidine on human platelet functions in vitro." Kyoto University, 2016. http://hdl.handle.net/2433/215391.

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6

Fischer, Daniel Friedrich. "New frontiers in asymmetric aza-Claisen rearrangements : development of ferrocenyl imidazoline palladacycles /." [S.l.] : [s.n.], 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=18128.

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7

Dupuy, Laurence. "Etude des effets cellulaires et des mécanismes de transduction associés aux récepteurs des imidazolines de sous type I1." Strasbourg 1, 2004. http://www.theses.fr/2004STR13069.

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Les cellules PC12 expriment le récepteur I1 des imidazolines (RI1) qui est localisé sur la membrane plasmique. Au cours de ce travail, nous avons étudié les voies de transduction associées au RI1 ainsi que son influence sur l'apoptose. Nous avons montré que la stimulation des RI1 provoque une diminution de l'AMPc intracellulaire par l'inhibition de l'adénylate cyclase qui est insensible à la toxine pertussique excluant l'implication d'une protéine G de type Gi/o. Cette voie co-existe avec celle de la phosphatidylcholine phospholipase C dont la stimulation entraîne une augmentation de diacylgly

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8

Slough, Scott. "The effect of a novel series of imidazoline compounds on glucose homeostasis in the mouse." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340266.

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9

Hower, Amy Elizabeth. "Receptor Functions of the Receptor-Type Protein Tyrosine Phosphatase PTPRO." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/303.

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Protein tyrosine phosphorylation regulates many aspects of cell growth and differentiation. Since cellular tyrosine phosphorylation levels are controlled by the antagonizing actions of the protein tyrosine kinases (PTKs) and the protein tyrosine phosphatases (PTPs), these enzymes play a direct role in regulating processes as diverse as oncogenesis and neuronal development. In particular, the transmembrane group of PTPs, known as the receptor-type protein tyrosine phosphatases (RPTPs), has been linked to regulation of axon growth and guidance during development and regeneration. The regulati

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10

Bolton, L. W. Y. T. "Recombinant TGF-beta type I and type II receptor domains." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596753.

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Transforming growth factor-β (TGF-β) is a multifunctional cytokine that signals by binding to two related transmembrane serine/threonine kinases called the type I and type II receptors. The <I>in vitro</I> binding properties of these receptors for the TGF-β1 and TGF-β3 isoforms were investigated by developing expression systems for recombinant extracellular domains (ECDs) of the type I and type II receptors, which also enabled the interaction of the two receptor domains to be examined. 1. A variety of vectors were constructed incorporating the fusion protein glutathione S transferase (GST) and

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11

Tang, Bolton Lina Wai Yue. "Recombinant TGF-β type I and Type II receptor domains". Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624532.

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12

Hatcher-Solis, Candice N. "PHARMACOLOGICAL IMPLICATIONS OF ADENOSINE 2A RECEPTOR- DOPAMINE TYPE 2 RECEPTOR HETEROMERIZATION." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4458.

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G protein-coupled receptors (GPCRs) are heptahelical, transmembrane proteins that mediate a plethora of physiological functions by binding ligands and releasing G proteins that interact with downstream effectors. GPCRs signal as monomers, complexes of the same receptor subtype (homomers), or complexes of different receptor subtypes (heteromers). Recently, heteromeric GPCR complexes have become attractive targets for drug development since they exhibit distinct signaling and cell-specific localization from their homomeric counterparts. Yet, the effect of heteromerization on the pharmacology of

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13

Mayer, GaeÌˆll. "Characterisation of a gold thioglucose model of type II diabetes and obesity : effects of imidazoline ligands on glucose homeostasis." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271834.

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14

Laporte, Franck. "Traitement et perspectives de traitement du diabète de type II." Bordeaux 2, 2000. http://www.theses.fr/2000BOR2P089.

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15

Vincent, Karla Kristine. "Transactivation of Beta 2 Adrenergic Receptor by Bradykinin type 2 Receptor via heterodimerization." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/37117.

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Although a long standing convention maintained that G Protein Coupled Receptors (GPCRs) exist in the plasma membrane solely as monomers, substantial work over the last two decades has demonstrated that these ubiquitous receptors can and in many cases, preferentially, exist as homodimers, heterodimers, or higher order oligomers. Often, two GPCRs of the same class heterodimerize; it is less common for two GPCRs of different signaling pathways to interact. The work presented here studied the physical and functional interaction of two GPCRs from discrete classes, the Beta 2 Adrenergic Receptor

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16

Kerscher, Berhard Gerhard Richard. "Characterisation of the C-type lectin receptor Clecsf8." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230779.

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C-type lectin-like receptors (CTLRs) play critical roles in immunity and homeostasis by recognising a variety of microbial or endogenous ligands. Clecsf8 is a member of the Dectin-2 family of CTLRs. Clecsf8 shares important similarities with its relatives Mincle and Dectin-2, such as the lack of an integral signalling motif and a single, calcium dependent ligand binding domain. They were shown to associate with the FcRγ adaptor, which is essential for receptor surface expression and downstream signalling. Recent publications revealed an important role for Clecsf8 in anti-mycobacterial immunity

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17

Phillips, Timothy Trevor. "A study of metabotropic glutamate receptor type 2." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624330.

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18

Bayraktutan, Ulvi. "Studies on human urokinase-type plasminogen activator receptor." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262679.

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19

Waugh, Sheila M. L. "Enterovirus type 70 : receptor interactions and cell entry." Thesis, University of Glasgow, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479037.

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20

Walker, Micaela. "Biochemical characterisation of the type 3 ryanodine receptor." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286791.

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21

Ahmed, Mohaned S. A. "New C-C chemokine receptor type 7 antagonists." Thesis, University of Bradford, 2016. http://hdl.handle.net/10454/14623.

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Chemokines are chemotactic cytokines which play an important role in the migration of immune cells to distant tissues or compartments within tissues. These proteins have also been demonstrated to play a major role in cancer metastasis. The C-C chemokine receptor type 7 (CCR7) is a member of the chemokine receptor family. CCR7 along with its ligands CCL19 and CCL21 plays an important role in innate immune response by trafficking of lymphocytes. In cancer, tumour cells expressing CCR7 migrate to lymphoid organs and thus disseminate to other organs. Neutralizing the interactions between CCL21/CCR

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22

Rahman, Md Taufiq-Ur. "Patch-clamp studies of type 3 IP₃ receptor." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612118.

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23

Nandedkar, Neha Dhananjay. "Autoantigens and Insulin Receptor in Type 1 Diabetes." University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1556215572248676.

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24

DE, DOMENICO EMANUELA. "Role of type-2 cannabinoid receptor in reproduction." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2016. http://hdl.handle.net/2108/202948.

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25

Wu, Xiaofeng_. "Roles of angiotensin type 1 receptor signaling in neuroprotection." 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/120524.

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26

de, Bock Charles Edo St George Clinical School UNSW. "Novel protein interactors of urokinase-type plasminogen activator receptor." Awarded by:University of New South Wales. St George Clinical School, 2005. http://handle.unsw.edu.au/1959.4/23009.

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The plasminogen activator (PA) system plays an important role in cell adhesion, migration and invasion, and may require the coordinated expression of various proteins. The human urokinase-type plasminogen activator (uPA) receptor (uPAR) is a central protein component of the PA system. By binding its ligand uPA, uPAR can direct proteolysis of the extracellular matrix. Also, it is now apparent that uPAR can initiate proteolytic independent signal transduction to influence angiogenesis, inflammation, wound repair and tumour progression. To determine whether any novel proteins interacted with uPAR

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27

Sophocleous, Antonia. "Role of type 2 cannabinoid receptor in bone metabolism." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/5940.

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Cannabinoid receptors play an important role in regulating bone mass and bone turnover. Studies in our laboratories have shown that young mice lacking type 1 cannabinoid receptor (CNR1-/-) had increased bone mass and were resistant to ovariectomy-induced bone loss. Other workers have reported that type 2 cannabinoid receptor knockout mice (CNR2-/-) develop age-related osteoporosis. The aim of this PhD thesis was to further investigate the role of CNR2 in bone metabolism in vitro and in vivo, using genetic and pharmacological approaches. This study showed that CNR2-/- mice had normal bone mass

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28

Netherland, Courtney Denise. "Role of Type 2 Cannabinoid Receptor (CB2) in Atherosclerosis." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1392.

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Atherosclerosis is a macrophage-dominated nonresolving inflammatory disease of the arterial wall. Macrophage processes, including apoptosis, influence lesion development in atherosclerosis. Cannabinoids, compounds structurally related to Δ9-tetrahydrocannabinol (THC), the active ingredient in marijuana, exert their effects through cannabinoid receptors, CB1 and CB2. Cannabinoid treatment, THC or Win55,212-2, reduces atherosclerosis in ApoE-null mice by a mechanism thought to involve CB2. However, the exact role of CB2 in atherosclerosis remains unclear. We found that CB2-null macrophages are r

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29

Sy, Guata Yoro. "Implication du monoxyde d'azote endogène (NO) et des canaux potassiques de type Girk dans la régulation centrale de la fonction cardiovasculaire : effets des anti-hypertenseurs centraux." Strasbourg 1, 2003. http://www.theses.fr/2003STR13197.

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Le but de ce travail était d'étudier les rôles du monoxyde d'azote (NO) endogène et des canaux potassiques de rectification entrante de type GIRK " G-protein indwardly rectifier potassium channel " dans les effets cardiovasculaires centraux des catécholamines et des imidazolines. Les expériences ont été réalisées chez des lapins anesthésiés au pentobarbital et les drogues ont été administrées par voie intra-cisternale ou en injections dans le noyau réticulaire latéral (NRL) et/ou le noyau du faisceau solitaire (NFS). Les effets cardiovasculaires centraux des drogues qui agissent sur les récept

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30

Mertens, Jan Stephan. "GABAA receptor heterogeneity : immunochemical and pharmacological characterization of receptor subtypes /." Zürich, 1993. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10294.

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31

Thomas, Jennifer Ann. "Engineering the angiotensin II type 1 receptor for structural studies." Thesis, University of Cambridge, 2015. https://www.repository.cam.ac.uk/handle/1810/247919.

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G protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that perform transmembrane signal transduction. Due to their pivotal role in a wide range of essential physiological functions GPCRs represent a high proportion of all drug targets. High resolution X-ray structures of GPCRs are however underrepresented in the Protein Data Bank. This is due to their instability in detergent, low expression levels and the presence of misfolded receptors in many heterologous expression systems. The objective of this project was to engineer the angiotensin II type 1 receptor (AT1R), a hu

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32

Zheng, Zhong. "ROLE OF SCAVENGER RECEPTOR CLASS B TYPE I IN THYMOPOIESIS." UKnowledge, 2014. http://uknowledge.uky.edu/nutrisci_etds/12.

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T cells, which constitute an essential arm in the adaptive immunity, complete their development in the thymus through a process called thymopoiesis. However, thymic involution can be induced by a couple of factors, which impairs T cell functions and is slow to recover. Therefore, understanding how thymopoiesis is regulated may lead effort to accelerate thymic recovery and improve immune functions in thymocyte-depleted patients. In this project, we identified scavenger receptor BI (SR-BI), a high density lipoprotein (HDL) receptor, as a novel modulator in thymopoiesis. In mice, absence of SR-BI

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33

Bertocchini, Federica. "Expression and functional analysis of murine ryanodine receptor type 3." Thesis, Open University, 1998. http://oro.open.ac.uk/57732/.

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Ryanodine receptors (RyRs) are intracellular homotetrameric Ca2+-release channels constituting a family of three different isoforms, named RyRl, RyR2 and RyR3. RyRl and RyR2 are highly expressed in skeletal and cardiac muscles respectively, where they localize in the terminal cisternae of the sarcoplasmic reticulum (SR). Although RyRl and RyR2 have been found to be expressed in several other tissues at much lower level than in striated muscles, their major functional role is related to Ca2+-release from the SR following electrical depolarization of the plasma membrane, a process referred to as

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34

Tchetchelnitski, V. "Regulation of neurotrophin receptors by receptor-type protein tyrosine phosphatases." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1310477/.

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Reversible protein phosphorylation plays a key role in cell signalling during neural development and thus controls cell proliferation, survival, differentiation and function. Kinases and their counter-partners the phosphatases tightly regulate protein phosphorylation. In the developing nervous system the neurotrophin receptor family of protein tyrosine kinases (TrkA, B and C) are major players in this signalling network during normal neuron development and also in several diseases such as neuropathies, degenerative disorders and cancers. Recently, receptor-type protein tyrosine phosphatases (R

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35

Gilbert, Hannah Elizabeth. "Structural studies of SCR domains in complement receptor type two." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445515/.

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Complement receptor type 2 (CR2 CD21) is a type 1 membrane-bound glycoprotein in the regulators of complement activity (RCA) family. One of its ligands is C3d, a physiological cleavage fragment of the central complement protein C3. The extracellular portion is comprised of 15 or 16 short complement repeat (SCR) domains. Six of the 14 linkers between these SCR domains are atypically long and the implications of this on the solution structure and function of CR2 was unknown. Two previous crystal structures of CR2 SCR 1-2 showed the two SCR domains formed contacts with each other in a closed V-sh

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36

Pacitti, Elaine Grace. "The neuropharmacology of a slowly adapting type 1 sensory receptor." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/29930.

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The role of the Merkel cell-neurite complex in the transduction process in slowly adapting type 1 (SA1) cutaneous mechanoreceptors is unresolved. One hypothesis, based largely on the ultrastructure of Merkel cell-neurite complexes, suggests that chemosynaptic transmission occurs between the Merkel cell and its subjacent nerve terminal. This idea was investigated by mechanically stimulating SA1 mechanoreceptors exposed to pharmacologically active agents in several experimental preparations; an <i>in vivo</i> rat model, an <i>in vivo</i> feline isolated hind limb perfusion model and a novel isol

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37

Nassanian, Hoorig. "The biology of the C-Type lectin receptor DC-SIGN." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1627802281&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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38

Parola, Anthony Lawrence. "Pharmacological and molecular heterogeneity of the "peripheral-type benzodiazepine receptor"." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185185.

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The rat liver peripheral-type benzodiazepine receptor (PBR) was characterized by ligand binding with [³H]Ro5-4864 and by photolabeling using [³H]PK 14105. The native liver receptor could be solubilized with digitonin. The Mr of the native photolabeled receptor was 170 kDa while a single Mr 19 kDa protein was identified under denaturing conditions. Radioligand binding to rat liver subcellular fractions showed protoporphyrin IX had a 6.2-fold greater affinity for [³H]Ro5-4864 binding sites in mitochondria than in microsomes. Although heterogeneity of the rat liver benzodiazepine binding site, bu

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39

BONCORAGLIO, GIORGIO BATTISTA. "Role of Ryanodine Receptor type 3 (RyR3) in ischemic stroke." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/317052.

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L'ictus è una delle principali cause di mortalità e disabilità acquisita in tutto il mondo. Il primo studio di associazione genome-wide in pazienti con ictus ischemico italiano ha trovato un'associazione significativa con il polimorfismo missenso a singolo nucleotide (SNP) rs4780144 nel gene del recettore della rianodina di tipo 3 (RyR3), che porta a una potenziale perdita di funzione. Molteplici evidenze hanno suggerito che una ridotta funzione di RyR3 potrebbe migliorare l'esito dell'ictus. Con questo studio abbiamo mirato a indagare il ruolo di RyR3 nell'ictus ischemico a livello funzionale

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40

Parsons, Tina. "Receptor-mediated iron and haem transport in Haemophilus." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282581.

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41

Sidenius, Nicolai. "Urokinase receptor cleavage and shedding : occurrence and consequences." Thesis, Open University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323274.

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42

Saunders, Ruth Mary. "Modulation of type 1a metabotropic glutamate receptor signalling by extracellular Ca²+." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29923.

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This Thesis describes experiments in which the modulation of type 1 metabotropic glutamate receptor (mGluR1) signalling by [Ca2+]e has been studied. These experiments set out to investigate the Ca2+-sensitivity of mGluR1 expressed in a baby hamster kidney cell line. Increasing [Ca2+]e was demonstrated to enhance agonist-stimulated phosphoinositide signalling via mGluR1, but not the M3-muscarinic receptor, expressed in baby hamster kidney (BHK) cells, suggesting that the modulatory effect of Ca2+ is selective to signalling via mGluR1. The limitation of this modulatory effect of Ca2+e in BHK-S15

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43

Pirincci, Serife Seyda. "Comparison Of Fluorescent Protein Labelled And Wild Type Nmda Receptor Distribution." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615384/index.pdf.

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NMDA (N-methyl D-aspartate) Receptor is a ligand and voltage gated ion channel and involved in many processes such as synaptic plasticity, memory formation, behavioral responses and cell survival. In the sense of functional activity, cellular localization of NMDAR is important since this receptor shows its activity on the membrane. Although NMDA receptor is intensely studied there are no satisfying study showing its localization with microscobic methods. Besides, the effect of florescent protein labelling of NMDA receptor on its distribution is not shown. It is expected to provide basis

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44

Marshall, Andrew. "The characterisation of a novel C-type lectin-like receptor MICL." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409114.

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45

Robson, Andrew. "The role of the TGFβ type II receptor during heart development". Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500895.

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TGFβ signalling has long been recognised as having a role in heart development. The central TGFβ type II receptor (Tgfbr2) is thought to be essential for epithelialmesenchymal transition (EMT) in the atrioventricular cushions. However, little is known about the roles of Tgfbr2 in heart development in vivo. This is largely because the Tgfbr2 knockout (KO) shows early embryonic lethality during heart valve development. To bypass the early lethality of the TRfbr2 KO mouse and to investigate the role of Tgfbr2 during heart development, a cre/loxP system was used to generate three different conditi

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46

Zhao, Jing. "A-type receptor of atrial natriuretic peptide in spontaneously hypertensive rat." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627461.

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47

Ellis, James. "Structural analysis of the human angiotensin type 1 receptor through mutagenesis." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418731.

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48

Teli, Thalia. "Investigation of the corticotrophin-releasing hormone receptor type 1 alpha desensitization." Thesis, University of Warwick, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406807.

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49

Steer, Emma Jane. "The action of flecainide on the wild-type cardiac ryanodine receptor." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/18395/.

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The genetic disorder catecholaminergic polymorphic ventricular tachycardia (CPVT) causes the function of the sarcoplasmic reticulum (SR) Ca2+ release channel (RyR2) to be altered and induces fatal arrhythmias during stress or exercise. Flecainide, a class 1C sodium channel (Nav1.5) inhibitor and anti-arrhythmic agent, was recently observed to be effective against CPVT arrhythmias. Controversially, it was suggested that flecainide acted directly on RyR2, alongside its action on Nav1.5. The present study sought to establish whether flecainide affected RyR2 activity to prevent pro-arrhythmic Ca2+

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50

Clark, Alexandra Elsie. "Characterisation of the C-type lectin-like receptor 1 (CLEC-1)." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=210080.

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