Academic literature on the topic 'Imidazoline receptors agonists'

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Journal articles on the topic "Imidazoline receptors agonists"

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Maltsev, A. V., та Y. M. Kokoz. "Non-Central Influences of α2-Adrenergic and Imidazoline Agonist Interactions in Isolated ardiomyocytes Cardiac Cells". Kardiologiia 59, № 4 (2019): 52–63. http://dx.doi.org/10.18087/cardio.2019.4.10241.

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Aim: to investigate the functional interaction of α2-adrenergic and imidazoline receptors recently identified on the sarcolemma of isolated cardiomyocytes for regulation of the intracellular calcium and the production of the signal molecule of nitric oxide (NO).Materials and methods:experiments were performed on isolated left ventricular cardiomyocytes of Wistar rats. Potential-dependent Ca2+-currents were measured from the whole-cell by the patch-clamp method in “perforated-patch” configuration. The intracellular calcium and the production of nitric oxide were estimated from the changes in fl
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Nikolic, Katarina, and Danica Agbaba. "Imidazoline receptors ligands." Chemical Industry 66, no. 5 (2012): 619–35. http://dx.doi.org/10.2298/hemind120221037n.

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Extensive biochemical and pharmacological studies have determined three different subtypes of imidazoline receptors: I1-imidazoline receptors (I1-IR) involved in central inhibition of sympathicus that produce hypotensive effect; I2-imidazoline receptors (I2-IR) modulate monoamine oxidase B activity (MAO-B); I3-imidazoline receptors (I3-IR) regulate insulin secretion from pancreatic ?-cells. Therefore, the I1/I2/I3 imidazoline receptors are selected as new, interesting targets for drug design and discovery. Novel selective I1/I2/I3 agonists and antagonists have been recently developed. In the p
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Kagawa, Kiyokazu, Tadanori Mammoto, Yukio Hayashi, Takahiko Kamibayashi, Takashi Mashimo та Ikuto Yoshiya. "The Effect of Imidazoline Receptors and α2-adrenoceptors on the Anesthetic Requirement (MAC) for Halothane in Rats". Anesthesiology 87, № 4 (1997): 963–67. http://dx.doi.org/10.1097/00000542-199710000-00032.

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Background Recent evidences have documented that several pharmacologic actions of alpha2-adrenoceptor agonists are mediated via activation of not only alpha2-adrenoceptors, but also by imidazoline receptors, which are nonadrenergic receptors in the central nervous system. However, the effect of imidazoline receptors on the anesthesia is not well known, and it is important to clarify the effects of both receptors on anesthesia. Methods Seventy-two rats were anesthetized with halothane, and the anesthetic requirement for halothane was evaluated as minimum alveolar concentration (MAC). The MAC fo
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Ernsberger, Paul, and Musa A. Haxhiu. "The I1-imidazoline-binding site is a functional receptor mediating vasodepression via the ventral medulla." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 273, no. 5 (1997): R1572—R1579. http://dx.doi.org/10.1152/ajpregu.1997.273.5.r1572.

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I1-imidazoline-binding sites fulfill all essential criteria for identification as receptors, including specificity of binding, association with physiological functions, appropriate anatomic and cellular and subcellular localization, and specific cell signaling pathways. Moreover, binding affinities correlate with functional drug responses. The evidence linking I1 receptors to vasodepression includes expression in RVLM and consistent correlations between vasodepressor potency in humans and animals and I1 binding affinity. Some I1 agonists are antagonists at α2-adrenergic receptors (α2AR), and t
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Prichard, Brian N., and Barrie R. Graham. "I1 Imidazoline Agonists. General Clinical Pharmacology of Imidazoline Receptors." Drugs & Aging 17, no. 2 (2000): 133–59. http://dx.doi.org/10.2165/00002512-200017020-00005.

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Soldatov, Vladislav O., Elena A. Shmykova, Marina A. Pershina, et al. "Imidazoline receptors agonists: possible mechanisms of endothelioprotection." Research Results in Pharmacology 4, no. 2 (2018): 11–19. http://dx.doi.org/10.3897/rrpharmacology.4.27221.

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Imidazoline receptor agonists are one of the groups of contemporary antihypertensive drugs with the pleiotropic cardiovascular effects. In this review, the historical, physiological, pathophysiological aspects concerning imidazoline receptor agonists and possible mechanisms for their participation in endothelioprotection were considered. Illuminated the molecular biology of each subtype of imidazoline receptors and their significance in the pharmacological correction of cardiovascular disease. IR type 1 are localized in the brain nucleus, carrying out the descending tonic control of sympatheti
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Soldatov, Vladislav O., Elena A. Shmykova, Marina A. Pershina, et al. "Imidazoline receptors agonists: possible mechanisms of endothelioprotection." Research Results in Pharmacology 4, no. (2) (2018): 11–18. https://doi.org/10.3897/rrpharmacology.4.27221.

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Imidazoline receptor agonists are one of the groups of contemporary antihypertensive drugs with the pleiotropic cardiovascular effects. In this review, the historical, physiological, pathophysiological aspects concerning imidazoline receptor agonists and possible mechanisms for their participation in endothelioprotection were considered. Illuminated the molecular biology of each subtype of imidazoline receptors and their significance in the pharmacological correction of cardiovascular disease. IR type 1 are localized in the brain nucleus, carrying out the descending tonic control of sympatheti
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Dovgan, A. P., S. V. Povetkin, G. A. Batishcheva, A. A. Dolzhikov, M. V. Pokrovsky, and Z. S. Urozhevskaya. "Possible ways of pharmacological correction of ischemic liver damages using agonist of peripheral imidazoline receptors c7070." I.P. Pavlov Russian Medical Biological Herald 26, no. 1 (2018): 21–35. http://dx.doi.org/10.23888/pavlovj2018121-35.

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A comorbid condition both in diabetes mellitus and in metabolic syndrome is fatty dystrophy of the liver that further progresses to hepatic necrosis. In the article variants of pharmacological correction of ischemia-reperfusion of the liver with agonists of imidazoline receptor are proposed.
 Materials and Methods. The experiment was conducted on 70 rats of both sexes divided into 7 groups (n=10): intact group; pseudo-operated animals (incision of the abdominal wall without ligation of hepatic vessels); animals subject to ischemia/reperfusion without drug correction; animals subject to is
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Dovgan, A. P., S. V. Povetkin, G. A. Batishcheva, A. A. Dolzhikov, M. V. Pokrovsky, and Z. S. Urozhevskaya. "Possible ways of pharmacological correction of ischemic liver damages using agonist of peripheral imidazoline receptors c7070." I.P. Pavlov Russian Medical Biological Herald 26, no. 1 (2018): 21–35. http://dx.doi.org/10.23888/pavlovj201826121-35.

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A comorbid condition both in diabetes mellitus and in metabolic syndrome is fatty dystrophy of the liver that further progresses to hepatic necrosis. In the article variants of pharmacological correction of ischemia-reperfusion of the liver with agonists of imidazoline receptor are proposed.
 Materials and Methods. The experiment was conducted on 70 rats of both sexes divided into 7 groups (n=10): intact group; pseudo-operated animals (incision of the abdominal wall without ligation of hepatic vessels); animals subject to ischemia/reperfusion without drug correction; animals subject to is
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Shetty, Sadanand, Anil Bhoraskar, J. C. Mohan, et al. "Selective imidazoline receptor agonists: redefining role of centrally acting agents in role of centrally acting agents in management of hypertension." International Journal of Advances in Medicine 6, no. 5 (2019): 1688. http://dx.doi.org/10.18203/2349-3933.ijam20194234.

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Hypertension, often referred to as ‘The silent killer’, is christened so, as it is seldom preceded by any warning signs or symptoms. With the new ACC/AHA guidelines lowering the Blood Pressure (BP) threshold values, it has resulted in a 140% relative increase in the hypertension prevalence in India, which is 3 times higher than that of in United States. Imidazoline receptor agonists control BP effectively with minimal adverse effects of sedation and mental depression that are usually associated with centrally acting antihypertensives. While having a low affinity to the α2-adrenergic receptors,
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Dissertations / Theses on the topic "Imidazoline receptors agonists"

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Pirnat, Deni. "The importance of the renal sympathetic nerves in the natriuretic response to imidazoline receptor agonists." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ62822.pdf.

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Kashamalla, Chinna Ashalu [Verfasser]. "Enantioselective synthesis of tetrahydrofuran-imidazole based human histamine H3 and H4 receptor agonists / vorgelegt von Chinna Ashalu Kashamalla." 2009. http://d-nb.info/1007689617/34.

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Books on the topic "Imidazoline receptors agonists"

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A, Hamilton C., Prichard B. N. C, Zwieten P. A. van, and Royal Society of Medicine Services (Great Britain), eds. The I₁-imidazoline receptor agonist moxonidine: A new antihypertensive. Royal Society of Medicine Services Limited, 1994.

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van, Zwieten P. A., ed. The I[subscript 1]-imidazoline receptor agonist moxonidine: A new antihypertensive. 2nd ed. Royal Society of Medicine, 1996.

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P.A.Van Zwieten (Editor), C. A. Hamilton (Editor), B.N.C. Prichard (Editor), and S. Julius (Editor), eds. The I1-Imidazoline Receptor Agonist Moxonidine. 2nd ed. Royal Society of Medicine Press Ltd, 1996.

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P.A.Van Zwieten (Editor), C. A. Hamilton (Editor), and B.N.C. Prichard (Editor), eds. The I1-Imidazoline Receptor Agonist Moxonidine. Royal Society of Medicine Press Ltd, 1994.

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Book chapters on the topic "Imidazoline receptors agonists"

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Tomassoni, Anthony J. "Alpha-2 Adrenergic and Imidazoline Receptor Agonists: Clonidine, Dexmedetomidine, and Related Antihypertensives, Decongestants, and Sedatives." In Critical Care Toxicology. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-20790-2_27-1.

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Tomassoni, Anthony J. "Alpha-2 Adrenergic and Imidazoline Receptor Agonists: Clonidine, Dexmedetomidine, and Related Antihypertensives, Decongestants, and Sedatives." In Critical Care Toxicology. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-17900-1_27.

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