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Relevant bibliographies by topics / Imidazopyridine

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Journal articles

Academic literature on the topic 'Imidazopyridine'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 June 2025

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Journal articles on the topic "Imidazopyridine"

1

Sonawane, Ravindra S., Kiran D. Patil, and Avinash V. Patil. "Design, Synthesis and Pharmacological Evaluation of Novel Imidazopyridine Analogues as Proton Pump Antagonist." Asian Journal of Chemistry 32, no. 4 (2020): 776–82. http://dx.doi.org/10.14233/ajchem.2020.22433.

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A series of novel imidazopyridine derivatives as proton pump inhibitors was designed with compounds of CID data base and explored considering AZD0865 as standard. Many compounds were identified and docked in proton pump ATPase pocket (PDB ID: 4ux2). Molecular docking studies revealed that many compounds showed good proton pump ATPase inhibitory activity. The docking poses revealed the interaction of ligands with amino acid. The standard drug AZD0865 had docking score of -7.112302 and displayed interactions with Asn138 and Asp137. A series of novel imidazopyridine derivatives as proton pump inhibitors were docked, synthesized and characterized by IR, NMR, CHN and MS spectral analysis. The target imidazopyridines were prepared from substituted 2-aminonicotinic acid and 2-bromo-1-substituted ethanone. in vitro Studies explained that few compounds exhibited moderate to good proton pump ATPase inhibitory activity in comparison with the reference drugs i.e. AZD0865. Compounds 11 and 12 shown higher activities with the IC50 4.3. Compounds 1, 4, 6, 7, 8, 10 and 13 showed weak anti-ulcer activity with its IC50 5.2, 5.8, 5.5, 5.1, 4.9, 4.6 and 5.9 and positive control AZD0865 shown IC50 2.0.

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2

Sonawane, R. S., Mrunal Shirsat, S. R. Patil, J. C. Hundiwale, and A. V. P. atil. "Design and Synthesis of Novel Imidazopyridine Analogues and Evaluation as H+/K+-ATPase Antagonist." Asian Journal of Chemistry 32, no. 11 (2020): 2685–92. http://dx.doi.org/10.14233/ajchem.2020.22697.

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CID data base were explored considering AZD0865 as standard and docked in proton pump ATPase pocket (PDB ID: 4ux2) to find out novel imidazopyridine derivatives as proton pump inhibitors. A number of compounds showed good proton pump ATPase inhibitory activity as per the molecular docking study as compared to standard compound AZD0865. The compound AZD0865showed a docking score of -7.11 and revealed the interactions with amino acids Asn 138 and Asp 137. A series of novel imidazopyridine derivatives as proton pump inhibitors were docked, synthesized and characterized by IR, NMR, CHN and MS spectral analysis. The target imidazopyridines were prepared from the intermediate substituted 2-aminonicotinic acid and 2-bromo-1-substituted ethanone. in vitro pharmacological studies explained that some compounds exhibited moderate to good proton pump ATPase inhibitory activity in comparison with the reference drugs i.e. AZD0865. Compound N-(3-(aminomethyl)benzyl)-3-(benzylamino)-2-(o-tolyl)imidazo[1,2-a]pyridine-8-carboxamide and N-(3-(aminomethyl)benzyl)-3-(benzylamino)-2-(4-ethylphenyl)imidazo[1,2-a]pyridine-8-carboxamide showed higher activities with the IC50 6.2 and 6.0 μg. Many compounds showed IC50 as weak antiulcer activity as compared to positive control AZD0865.

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3

Peterson, Emily A., Alessandro A. Boezio, Paul S. Andrews, et al. "Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors." Bioorganic & Medicinal Chemistry Letters 22, no. 15 (2012): 4967–74. http://dx.doi.org/10.1016/j.bmcl.2012.06.033.

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4

Carreño, Alexander, Manuel Gacitúa, Juan A. Fuentes, et al. "Theoretical and experimental characterization of a novel pyridine benzimidazole: suitability for fluorescence staining in cells and antimicrobial properties." New Journal of Chemistry 40, no. 3 (2016): 2362–75. http://dx.doi.org/10.1039/c5nj02772a.

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5

Kamal, Ahmed, G. Bharath Kumar, V. Lakshma Nayak, et al. "Design, synthesis and biological evaluation of imidazopyridine/imidazopyrimidine-benzimidazole conjugates as potential anticancer agents." MedChemComm 6, no. 4 (2015): 606–12. http://dx.doi.org/10.1039/c4md00400k.

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6

Priyanga, Selvarasu, Themmila Khamrang, Marappan Velusamy, Sellamuthu Karthi, Balasubramaniem Ashokkumar, and Ramasamy Mayilmurugan. "Coordination geometry-induced optical imaging of l-cysteine in cancer cells using imidazopyridine-based copper(ii) complexes." Dalton Transactions 48, no. 4 (2019): 1489–503. http://dx.doi.org/10.1039/c8dt04634d.

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7

Sayeed, Ibrahim Bin, V. Lakshma Nayak, Mohd Adil Shareef, Neeraj Kumar Chouhan, and Ahmed Kamal. "Design, synthesis and biological evaluation of imidazopyridine–propenone conjugates as potent tubulin inhibitors." MedChemComm 8, no. 5 (2017): 1000–1006. http://dx.doi.org/10.1039/c7md00043j.

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8

Parenty, Alexis, and Leroy Cronin. "One-Pot Synthesis of Imidazopyridine Derivatives." Synthesis 2008, no. 9 (2008): 1479–85. http://dx.doi.org/10.1055/s-2007-1000936.

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9

Shinde, Vikki N., Shiv Dhiman, Rangan Krishnan, Dalip Kumar, and Anil Kumar. "Synthesis of imidazopyridine-fused indoles via one-pot sequential Knoevenagel condensation and cross dehydrogenative coupling." Organic & Biomolecular Chemistry 16, no. 33 (2018): 6123–32. http://dx.doi.org/10.1039/c8ob01449c.

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10

Swami, Suman, Debasis Behera, Arunava Agarwala, Ved Prakash Verma та Rahul Shrivastava. "β-Carboline–imidazopyridine hybrids: selective and sensitive optical sensors for copper and fluoride ions". New Journal of Chemistry 42, № 12 (2018): 10317–26. http://dx.doi.org/10.1039/c8nj01851k.

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