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Journal articles on the topic 'Imipramine and antioxidant'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Chang, Geng-Ruei, Po-Hsun Hou, Chao-Min Wang, et al. "Imipramine Accelerates Nonalcoholic Fatty Liver Disease, Renal Impairment, Diabetic Retinopathy, Insulin Resistance, and Urinary Chromium Loss in Obese Mice." Veterinary Sciences 8, no. 9 (2021): 189. http://dx.doi.org/10.3390/vetsci8090189.

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Imipramine is a tricyclic antidepressant that has been approved for treating depression and anxiety in patients and animals and that has relatively mild side effects. However, the mechanisms of imipramine-associated disruption to metabolism and negative hepatic, renal, and retinal effects are not well defined. In this study, we evaluated C57BL6/J mice subjected to a high-fat diet (HFD) to study imipramine’s influences on obesity, fatty liver scores, glucose homeostasis, hepatic damage, distribution of chromium, and retinal/renal impairments. Obese mice receiving imipramine treatment had higher

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Réus, Gislaine Z., Roberto B. Stringari, Bruna de Souza, et al. "Harmine and Imipramine Promote Antioxidant Activities in Prefrontal Cortex and Hippocampus." Oxidative Medicine and Cellular Longevity 3, no. 5 (2010): 325–31. http://dx.doi.org/10.4161/oxim.3.5.13109.

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A growing body of evidence has suggested that reactive oxygen species (ROS) may play an important role in the physiopathology of depression. Evidence has pointed to the β-carboline harmine as a potential therapeutic target for the treatment of depression. The present study we evaluated the effects of acute and chronic administration of harmine (5, 10 and 15 mg/kg) and imipramine (10, 20 and 30 mg/kg) or saline in lipid and protein oxidation levels and superoxide dismutase (SOD) and catalase (CAT) activities in rat prefrontal cortex and hippocampus. Acute and chronic treatments with imipramine

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Hadjimitova, Vera, Trayko Traykov, Milka Mileva, and Stefan Ribarov. "Effect of Some Psychotropic Drugs on Luminol - Dependent Chemiluminescence Induced by O2–, •OH, HOCl." Zeitschrift für Naturforschung C 57, no. 11-12 (2002): 1066–71. http://dx.doi.org/10.1515/znc-2002-11-1220.

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We studied antioxidant activity of six neuroleptics (chlorpromazine, levomepromazine, promethazine, trifluoperazine and thioridazine) and two antidepressants (imipramine and amitriptyline) in the range of concentration of 10−7−10−4 м. We applied luminol-dependent chemiluminescence to test the ability of these drugs to scavenge the biologically relevant oxygen-derived species: hydroxyl radical, superoxide radical, hypochlorous acid in vitro. We found that the phenothiazines were powerful scavengers of hydroxyl and superoxide radicals. Chlorprothixene, amitriptyline and imipramine had no scaveng

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Mohan, Gaanappriya, and Amala Kesavan. "Dose-dependent anxiolytic and antioxidant efficacy of Piper betle." BIOINFOLET - A Quarterly Journal of Life Sciences 22, no. 2 (2025): 229–33. https://doi.org/10.5958/0976-4755.2025.00114.9.

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Present study was undertaken to investigate anxiolytic and antioxidant properties of a methanolic extract of Piper betle Linn. leaves in female Wistar rats subjected to Chronic Unpredictable Mild Stress (CUMS). Two doses (100 and 200 mg/kg) of the extract were administered orally and compared with imipramine – a standard anxiolytic agent. Behavioral assessments using the Elevated Plus Maze (EPM) indicated that the dose of 100 mg/kg body weight notably increased the transfer latency and decreased the time spent in the closed arms, signifying anxiolytic activity similar to that of imipramine. Co

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Parikshit, V. Choudhari, G. Kanse Vanita, Venkatachalam A., and R. Pal Punam. "Antidepressant and nootropic activity of aqueous extract of Bougainvillea glabra." World Journal of Advanced Research and Reviews 10, no. 1 (2021): 334–39. https://doi.org/10.5281/zenodo.4734597.

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The aim of this analysis was to assess antidepressant & nootropic capacity of Bougainvillea Glabra aqueous extract (BGAE). Forced swim test, tail suspension test, & tetrabenazine mediated catalepsy & ptosis models were used to assess BGAE's antidepressant efficacy in mice at doses of 250 & 500 mg/kg orally. Morris water maze with elevated plus maze (EPM) was used to test nootropic behaviour. Normal medications for antidepressant & nootropic function were imipramine (25 mg/kg) & piracetam (300 mg/kg), respectively. Antioxidant assays such as DPPH & TBARS were use

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Sinharoy, Debalina, Debanjan Mukhopadhyay, Shauroseni Palchoudhuri, Bidisha Ghosh, Sukhen Das, and Sujata G. Dastidar. "Distinct Antioxidant Activity of a Common Antidepressant Drug Imipramine." Free Radicals and Antioxidants 6, no. 2 (2016): 151–54. http://dx.doi.org/10.5530/fra.2016.2.4.

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Parikshit V. Choudhari, Vanita G. Kanse, A. Venkatachalam, and Punam R. Pal. "Antidepressant and nootropic activity of aqueous extract of Bougainvillea glabra." World Journal of Advanced Research and Reviews 10, no. 1 (2021): 334–39. http://dx.doi.org/10.30574/wjarr.2021.10.1.0163.

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The aim of this analysis was to assess antidepressant & nootropic capacity of Bougainvillea Glabra aqueous extract (BGAE). Forced swim test, tail suspension test, & tetrabenazine mediated catalepsy & ptosis models were used to assess BGAE's antidepressant efficacy in mice at doses of 250 & 500 mg/kg orally. Morris water maze with elevated plus maze (EPM) was used to test nootropic behaviour. Normal medications for antidepressant & nootropic function were imipramine (25 mg/kg) & piracetam (300 mg/kg), respectively. Antioxidant assays such as DPPH & TBARS were used to

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Todirascu-Ciornea, Elena, Heba A. S. El-Nashar, Nada M. Mostafa, et al. "Schinus terebinthifolius Essential Oil Attenuates Scopolamine-Induced Memory Deficits via Cholinergic Modulation and Antioxidant Properties in a Zebrafish Model." Evidence-Based Complementary and Alternative Medicine 2019 (December 2, 2019): 1–11. http://dx.doi.org/10.1155/2019/5256781.

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Schinus terebinthifolius is a plant well recognized for its therapeutic profile such as anti-inflammatory and antitumor activities, promoting antibacterial activity and antioxidant and antidiabetic properties. This study aimed at examining whether Schinus terebinthifolius memory-enhancing activities are mediated by cholinergic and brain antioxidant systems in a scopolamine zebrafish model. Schinus terebinthifolius essential oil (10, 25, and 50 μL/L) was delivered to zebrafish by immersion in water for 8 days. Memory deficits were induced by scopolamine (100 μM) administration. Zebrafish were d

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Choudhury Barua, Chandana, Lipika Buragohain, Farida Rahman, Ramakrishna Elancheran, and Hooriyah Rizavi. "Zanthoxylum Alatum Attenuates Chronic Restraint Stress Adverse Behavioral Effects Via the Mitigation of Oxidative Stress and Modulating the Expression of Genes Involved in Endoplasmic Reticulum Stress in Mice." Basic and Clinical Neuroscience Journal 13, no. 5 (2022): 647–60. http://dx.doi.org/10.32598/bcn.2022.1477.1.

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Introduction: The functions of the endoplasmic reticulum (ER) are important, particularly in the proteins’ synthesis, folding, modification, and transport. Based on traditional medicine and our previous studies on Zanthoxylum alatum in lipopolysaccharide-induced depressive behavior and scopolamine-induced impaired memory, the present study explored the role of hydroalcoholic extract of Z. alatum (ZAHA) seeds in reducing the ER stress in mice. Methods: The mice were restrained for 28 days in polystyrene tubes. ZAHA (100 and 200 mg/kg, PO) and imipramine (10 mg/kg, IP) were administered daily, 4

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Asadi, Kosar, Saeid Abbasi-Maleki, and Goudarz Sadeghi Hashjin. "Antidepressant-like effect of Cuminum cyminum essential oil on the forced swim and tail suspension tests in male mice." Journal of Shahrekord University of Medical Sciences 22, no. 4 (2020): 167–72. http://dx.doi.org/10.34172/jsums.2020.27.

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Background and aims: Several pharmacological and biological activities have been attributed to Cuminum cyminum L. (CC), including analgesic, antioxidant, anti-inflammatory, and anti-epileptic effects. In this regard, the present study evaluated the antidepressant-like effects of the CC essential oil (EO) on the forced swim test (FST) and tail suspension test (TST) in male mice. Materials and Methods: The gas chromatography-mass spectrometry (GC-MS) apparatus was used for detecting the chemical compounds of CC EO. In the present study, 72 male NMRI mice were randomly allocated to 12 groups (eac

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Neeraj, Kumar* N. Eloziia Preeti Kothiyal. "EVALUATION OF ANTIDEPRESSANT ACTIVITY OF AQUEOUS ROOT EXTRACT OF ARNEBIA BENTHAMII IN RATS." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 1956–64. https://doi.org/10.5281/zenodo.833447.

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Objective: Depression is an etiologically heterogeneous group of brain disorders characterized by a wide range of symptoms that reflect alterations in psychomotor cognitive and emotional processes. Arnebia benthamii is a high value medicinal plant rank second in the list of medicinal plant prioritized for Western Himalaya. The roots have antihelmenthic, antipyretic, antiseptic, antimicrobial and antioxidant properties. The present study was designed to evaluate the antidepressant activity of aqueous root extract of Arnebia benthamii in rats through behavioral assessment such as Force swim test

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Serefko, Anna, Joanna Lachowicz-Radulska, Aleksandra Szopa, et al. "The Novel Imipramine–Magnesium Complex Exerts Antidepressant-Like Activity in Mice Subjected to the Forced Swim Test and the Tail Suspension Test." Molecules 30, no. 3 (2025): 519. https://doi.org/10.3390/molecules30030519.

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The objective of this study was to assess the antidepressant efficacy of a novel imipramine–magnesium (IMI–Mg) complex in comparison to the administration of imipramine and magnesium individually. The study utilized adult male albino Swiss mice. Behavioral assessments were conducted using the forced swim test (FST) and the tail suspension test (TST). A locomotor activity test was conducted to exclude false positive results in the FST and TST. Moreover, the study assessed oxidative stress levels in the mice subjected to acute environmental stress by measuring glutathione peroxidase, glutathione

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Szopa, Aleksandra, Mariola Herbet, Ewa Poleszak, et al. "Evaluation of Antidepressive-like Behaviours and Oxidative Stress Parameters in Mice Receiving Imipramine-Zinc Complex Compound." International Journal of Molecular Sciences 24, no. 18 (2023): 14157. http://dx.doi.org/10.3390/ijms241814157.

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The study aimed to evaluate the antidepressant-like effects of an imipramine-zinc (IMI-Zn) complex compound on mice and assess the level of oxidative stress parameters. The research also investigated whether the IMI-Zn complex showed superior antidepressant activity compared to individual treatments of both compounds at effective doses and their joint administration at subtherapeutic doses. The study was conducted on mice. Forced swim (FST), tail suspension (TST), and locomotor activity tests were used for behavioral studies. The results demonstrated the IMI-Zn complex’s dose-dependent antidep

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Brinza, Ion, Mohamed A. El Raey, Walaa El-Kashak, Omayma A. Eldahshan, and Lucian Hritcu. "Sweroside Ameliorated Memory Deficits in Scopolamine-Induced Zebrafish (Danio rerio) Model: Involvement of Cholinergic System and Brain Oxidative Stress." Molecules 27, no. 18 (2022): 5901. http://dx.doi.org/10.3390/molecules27185901.

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Sweroside is a secoiridoid glycoside and belongs to a large group of naturally occurring monoterpenes with glucose sugar attached to C-1 in the pyran ring. Sweroside can promote different biological activities such as antifungal, antibacterial, hepatoprotective, gastroprotective, sedative and antitumor, antioxidant, and neuroprotective activities. Zebrafish were given sweroside (12.79, 8.35, and 13.95 nM) by immersion once daily for 8 days, along with scopolamine (Sco, 100 μM) 30 min before the initiation of the behavioral testing to cause anxiety and memory loss. Employing the novel tank divi

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Kolisek, Martin, Augusto C. Montezano, Gerhard Sponder, et al. "PARK7/DJ-1 dysregulation by oxidative stress leads to magnesium deficiency: implications in degenerative and chronic diseases." Clinical Science 129, no. 12 (2015): 1143–50. http://dx.doi.org/10.1042/cs20150355.

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Disturbed magnesium (Mg2+) homoeostasis and increased levels of OS (oxidative stress) are associated with poor clinical outcomes in patients suffering from neurodegenerative, cardiovascular and metabolic diseases. Data from clinical and animal studies suggest that MD (Mg2+ deficiency) is correlated with increased production of ROS (reactive oxygen species) in cells, but a straightforward causal relationship (including molecular mechanisms) between the two conditions is lacking. The multifactorial protein PARK7/DJ-1 is a major antioxidant protein, playing a key role in cellular redox homoeostas

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Ghasemi Jalal, Jina, and Shahin Hassanpour. "Effects of Betaine on Ameliorating Depression in Gonadectomized Male Rats." Iranian Journal of Veterinary Medicine 19, no. 02 (2025): 357–66. https://doi.org/10.32598/ijvm.19.2.1005466.

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Background: Depression is a major mental disorder categorized by mood impairment, and betaine has antinociceptive activity in mice. Objectives This study aimed to determine the antidepressive activity of betaine in gonadectomized male rats. Methods: Twenty adult male rats were allocated to four experimental groups. Group 1 was kept in the control group, and castration was performed in the other groups. Group 2 was the sham group, which was castrated without treatment. In the imipramine group, the rats were castrated and administered imipramine (15 mg/kg) for two weeks. In group 4, following ca

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Souza-Monteiro, José Rogério, Gabriela P. F. Arrifano, Ana Isabelle D. G. Queiroz, et al. "Antidepressant and Antiaging Effects of Açaí (Euterpe oleracea Mart.) in Mice." Oxidative Medicine and Cellular Longevity 2019 (July 24, 2019): 1–16. http://dx.doi.org/10.1155/2019/3614960.

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Depression is a mental disorder that affects 300 million people of all ages worldwide, but fewer than half of those with the condition receive adequate treatment. In addition, the high pharmacological refractoriness (affecting 30%-50% of patients) and toxicity of some classical antidepressants support the pursuit of new therapies. People with this condition show depressed mood, loss of pleasure, high levels of oxidative stress, and accelerated biological aging (decreased telomere length and expression of the telomerase reverse transcriptase (TERT), the enzyme responsible for telomere maintenan

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Alghamdi, Adel, Mansour Almuqbil, Mohammad A. Alrofaidi, et al. "Potential Antioxidant Activity of Apigenin in the Obviating Stress-Mediated Depressive Symptoms of Experimental Mice." Molecules 27, no. 24 (2022): 9055. http://dx.doi.org/10.3390/molecules27249055.

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This study aimed to examine the antidepressant properties of apigenin in an experimental mouse model of chronic mild stress (CMS). Three weeks following CMS, albino mice of either sex were tested for their antidepressant effects using the tail suspension test (TST) and the sucrose preference test. The percentage preference for sucrose solution and the amount of time spent immobile in the TST were calculated. The brain malondialdehyde (MDA) levels, catalase activity, and reduced glutathione levels were checked to determine the antioxidant potential of treatments. When compared to the control, a

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Duda, Weronika, Katarzyna Curzytek, Marta Kubera, et al. "The Effect of Chronic Mild Stress and Imipramine on the Markers of Oxidative Stress and Antioxidant System in Rat Liver." Neurotoxicity Research 30, no. 2 (2016): 173–84. http://dx.doi.org/10.1007/s12640-016-9614-8.

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O, Oyiborhorho, Akpovwre, CO, Avwotuhwaye FE, and Eduviere, AT. "Centella lujica® Supplement Ameliorates Depressive and Anxiety-Like Behaviour in Stressed Mice." Journal of Complementary and Alternative Medical Research 26, no. 7 (2025): 7–18. https://doi.org/10.9734/jocamr/2025/v26i7672.

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Depression and anxiety are prevalent neuropsychiatric disorders often exacerbated by chronic stress, necessitating the exploration of effective, natural therapeutic alternatives. Centella lujica, a known species within the Centella genus, has shown potential neuroprotective properties due to its antioxidant and anxiolytic compounds. This study investigated the effects of Centella lujica supplementation on depressive- and anxiety-like behaviours in mice subjected to 14 days chronic unpredictable mild stress (CUMS), a validated model of stress-induced mood disorders. Sixty adult male mice were d

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Alamri, Abdulhakeem S., Walaa F. Alsanie, Majid Alhomrani, and Syed Mohammed Basheeruddin Asdaq. "Plumbagin Attenuates Depression-Like Behavior in Mice by Modulating Dopamine Levels." Current Topics in Nutraceutical Research 20M, no. 1 (2022): M6—M10. http://dx.doi.org/10.37290/ctnr2641-452x.20m:m6-m10.

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This research was done to investigate the antidepressant properties of plumbagin using a chronic mild stress induced depression model in experimental animals. Albino mice of either sex were given 3 weeks of chronic mild stress and their antidepressant properties were assessed using the tail suspension test and sucrose preference test. The period of immobility in the tail suspension test and the percentage preference for sucrose solution were both recorded and compared. Plumbagin was given in three doses (4, 8, and 16 mg/kg). The immobility time in the tail suspension test was significantly dec

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Alsanie, Walaa F., Abdulhakeem S. Alamri, Osama Abdulaziz, et al. "Antidepressant Effect of Crocin in Mice with Chronic Mild Stress." Molecules 27, no. 17 (2022): 5462. http://dx.doi.org/10.3390/molecules27175462.

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This study aimed to investigate the antidepressant property of crocin (Crocetin digentiobiose ester) using a chronic mild stress (CMS)-induced depression model in experimental mice. The tail suspension test (TST) and the sucrose preference test were used to evaluate the antidepressant effect on albino mice of either sex after three weeks of CMS. The period of immobility in the TST and percentage preference for sucrose solution were recorded. By monitoring brain malondialdehyde (MDA) level, catalase (CAT) activity, and reduced glutathione (GSH) level, the antioxidant potential was assessed. Thr

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Sher, Ayaz Ali, Arshad Iqbal, Naveed Muhammad, Syed Lal Badshah, Abdul-Hamid Emwas, and Mariusz Jaremko. "Prokinetic and Laxative Effects of Chrozophora tinctoria Whole Plant Extract." Molecules 27, no. 7 (2022): 2143. http://dx.doi.org/10.3390/molecules27072143.

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Chrozophora tinctoria (Euphorbiaceae) has been used as an emetic, anthelminthic, and cathartic agent in traditional medicine. We used gas chromatography-mass spectrometry (GC-MS) to characterize the composition of ethyl acetate (EAC) and dichloromethane (DCMC) fractions from the whole Chrozophora tinctoria plant. EAC and DCMC fractions were evaluated for acetylcholinesterase (AChE) inhibitory activity and acute toxicity. Their effects on intestinal propulsive movement and spasmogenic activity of the gastrointestinal tract (GIT) muscle were also assessed. The compounds detected in both fraction

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Miri, Abdolhossein, Javad Sharifi-Rad, Kaveh Tabrizian, and Ali Akbar Nasiri. "Antinociceptive and Anti-Inflammatory Activities ofTeucrium persicumBoiss. Extract in Mice." Scientifica 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/972827.

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Background.Therapeutic properties ofTeucriumspecies as antioxidant, antibacterial, analgesic, anticancer, diuretic, and tonic compounds have been proved earlier.Materials and Methods. In this study, the antinociceptive and anti-inflammatory effects of the aqueous extract ofTeucrium persicumon chronic pain, sciatic nerve ligation as a model of neuropathic pain, and inflammatory models were investigated by formalin, hot-plate, and cotton pellet-induced granuloma models in mice, respectively.T. persicumaqueous extracts (100, 200, and 400 mg/kg) were orally gavaged for one week. On 8th day, the ti

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Nayak, Roopa P., and Ramesh Kumar Karri. "Evaluation of antidepressant properties of ethanolic extract of root of in Swiss albino mice." Indian Journal of Pharmacy and Pharmacology 9, no. 4 (2022): 231–35. http://dx.doi.org/10.18231/j.ijpp.2022.042.

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Mental health has always been given a prime importance along with physical health by the World Health Organization (WHO). Depression contributes to significant disease burden at global level and is ranked by WHO as the single largest contributor to global disability. Oxidative stress plays an important role in the pathogenesis of many neurological conditions such as depression. is known to possess antioxidant properties; hence, this study has been conducted to evaluate the antidepressant activity of Rubia cordifolia root extract in rodent models. Ethanolic extract of root powder (EERC) was use

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Désiré, Guedang Nyayi Simon, Foyet Harquin Simplice, Camdi Woumitna Guillaume, et al. "Cashew (Anacardium occidentale) Extract: Possible Effects on Hypothalamic–Pituitary–Adrenal (HPA) Axis in Modulating Chronic Stress." Brain Sciences 13, no. 11 (2023): 1561. http://dx.doi.org/10.3390/brainsci13111561.

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Depression presents a significant global health burden, necessitating the search for effective and safe treatments. This investigation aims to assess the antidepressant effect of the hydroethanolic extract of Anacardium occidentale (AO) on depression-related behaviors in rats. The depression model involved 42 days of unpredictable chronic mild stress (UCMS) exposure and was assessed using the sucrose preference and the forced swimming (FST) test. Additionally, memory-related aspects were examined using the tests Y-maze and Morris water maze (MWM), following 21 days of treatment with varying do

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Gubergrits, N. B. "Ademetionine: from pharmacology to the clinical efficacy. Clinical application and its perspectives based on evidence-based medicine." Herald of Pancreatic Club 66, no. 1 (2025): 33–50. https://doi.org/10.33149/vkp.2025.01.02.

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The article presents the detailed analysis of literature concerning ademetionine physiological role in biochemical processes. There was conducted pathophysiological substantiation of Heptral appropriateness in treatment of liver cholestatic diseases, alcoholic liver disease, nonalcoholic fatty liver disease, liver drug injuries, viral hepatitis. There was described antidepressant properties of Heptral® and its significance in different psychic pathology as well. Pathophysiological and experimental data were illustrated with results of clinical trials, which justify effectiveness of the prepara

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Rajwinder, Kaur, Rajmeet Singh, Lalit, Kaur Jaswinder, and Rajat. "Evaluation of the Antidepressant Like Activity of Ethanolic Extract of Calendula officinalis using Rodent Models (Wistar Rat) of Depression." Current Psychopharmacology 9, no. 1 (2020): 58–67. http://dx.doi.org/10.2174/2211556009666200217122202.

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Background: Depression disorder has been considered to be the global common psychological CNS disorder affecting about 121 million people worldwide and is among the leading causes of disability that not only inflicts suffering but also carries a high economic burden. Calendula officinalis L. (Marigold) is globally known for its medicinal importance containing various phytochemicals including terpenoids, quinones, coumarins and other constituents, showing some important biological activities like immuno-stimulant, hepatoprotective, antioxidant, etc. activities with no toxic effect. Objective: T

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Mande, Annie, Narender Malothu, Anka Rao Areti, and Chakravarthi Guntupalli. "Evaluation of antidepressant and nootropic activities of leaf extracts of Rhizophora apiculata." Egyptian Pharmaceutical Journal 22, no. 4 (2023): 557–66. http://dx.doi.org/10.4103/epj.epj_4_23.

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Background Rhizophora (R.) apiculata is a traditional mangrove plant having antioxidant, anti-inflammatory, and central analgesic activities. Objective The current study was performed to assess the beneficial neurological activities of the plant using rodent models and also to explore the phytochemical distribution of plant extracts using the hyphenated analytical technique. Materials and methods Ethyl alcohol and aqueous extracts were subjected to phytochemical screening, followed by GC-MS analyses. In experimental studies, the animals were divided into normal, positive control (standard), ne

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Dr., Manojkumar Mahajan* Roshan wagh Sumitkumar Sharma Sunil Pandit Dr. Aman Upaganlwar Dr. Chandrashekar Upasani. "Pharmacological Assessment Of Formononetin On Behavior, Cognitive Function And Oxidative Stress In Mice." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 763–71. https://doi.org/10.5281/zenodo.12734103.

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<strong>Introduction:</strong> This study was designed to investigate the chronic effects of Formononetin on behavior; cognitive function and oxidative stress in mice. <strong>Materials and Methods:</strong> Male albino mice of either sex (25 – 30 gm) were used in the study. The mice were divided into six different groups (n=6). Group 1: Control group received water. Group II: Mice received 5mg/kg/day, p.o. Formononetin for 21 days. Group III: Mice received 20mg/kg/day, p.o. Formononetin for 21 days. Group IV: Mice received 50mg/kg/day, p.o. Formononetin for 21 days. Group V: Mice receiv

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Wang, Zhengqi, Tian Mi, Heath L. Bradley, et al. "Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia." Antioxidants 10, no. 6 (2021): 956. http://dx.doi.org/10.3390/antiox10060956.

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Acute myeloid leukemia (AML) is a heterogeneous disease with a high relapse rate. Cytokine receptor targeted therapies are therapeutically attractive but are subject to resistance-conferring mutations. Likewise, targeting downstream signaling pathways has been difficult. Recent success in the development of synergistic combinations has provided new hope for refractory AML patients. While generally not efficacious as monotherapy, BH3 mimetics are very effective in combination with chemotherapy agents. With this in mind, we further explored novel BH3 mimetic drug combinations and showed that pim

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Sharma, Abhishek, Dinesh Dhingra, Rubina Bhutani, Amit Nayak, and Adish Garg. "Depression: Reminiscent Behavior Induced by Chronic Unpredictable Mild Stress Paradigm in Mice Substantially Abrogated by Diosmin." Current Psychiatry Research and Reviews 20 (January 11, 2024). http://dx.doi.org/10.2174/0126660822261988231127072951.

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Background:: Diosmin has already been described and documented to be neuroprotective, antioxidant and anti-inflammatory. It may possess or hold depressionalleviating activity. Therefore, the purpose of the current research protocol is to investigate the depression-relieving proficiency of diosmin in stressed and unstressed mice. Methods:: Male mice (Swiss albino) were imperiled to an unpredictable chronic stress paradigm every day for three sequential weeks, and depression-resembling behavioral despair was induced. Imipramine 15 mg/kg and diosmin (25, 50 and 100 mg/kg) were dispensed for 21 su

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Seyedi, Seyed Sepehr, Saeid Abbasi-Maleki, and Ghader Najafi. "Phytochemical Properties and Antidepressant Potential of Satureja khuzestanica Jamzad Essential Oil in Mouse Models of Depression." Traditional and Integrative Medicine, December 21, 2023. http://dx.doi.org/10.18502/tim.v8i4.14481.

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Oxidative stress may play a pivotal role in the pathogenesis of depression. Furthermore, antioxidants are also believed to have antidepressant properties. Previous studies have reported the antioxidant effects of Satureja khuzestanica Jamzad. Therefore, this study examined the antidepressant potential of Satureja khuzestanica essential oil (SKEO) in male mice based on a forced swim test (FST) and tail suspension test (TST). The GC-MS was used to evaluate the phytochemistry of SKEO. In behavioral studies, 72 male mice were allocated to twelve groups of six and intraperitoneally received the veh

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Shaida, Bushra, Karuna Singh, and Mayuri Rastogi. "Evaluation of In-vitro Antioxidant and In-vivo Antidepressant properties of Flax seed Extract (Linum usitatisimum, L.)." Research Journal of Pharmacy and Technology, November 30, 2023, 5005–9. http://dx.doi.org/10.52711/0974-360x.2023.00810.

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Flax seed (Linum usitatisimum, L.) extract have been used for the treatment of numerous diseases. Despite of its health benefits, its action was not much studied on neurotic disorders like depression and anxiety. Thus the objective of the presentresearch work was to explorein-vitro antioxidant activity and in-vivo anti-depressive and anti-anxiety property of seed extract. The extraction method were optimized to yield the highest contents of biochemical compounds and antioxidant activities, further extract was evaluated for phytochemicals. The antioxidant potential of the extract was assessedus

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Sharma, Abhishek, Rahul Singh, Inderjeet Yadav, et al. "An In vivo Investigation to Assess Antidepressant Potential of Cannabidivarin in Stress-induced Depression in Mice." Current Psychiatry Research and Reviews 21 (May 27, 2025). https://doi.org/10.2174/0126660822365895250522091145.

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Background: Cannabidivarin, a non-psychotropic phytocannabinoid, has been identified and recognized for its antioxidant and neuroprotective properties, with potential effects on central nervous system (CNS) ailments. Objective: The purpose of the present study was to investigate the antidepressant potential of cannabidivarin in both stressed and unstressed mice via the CUMS (chronic unpredictable mild stress) model through in vivo analysis. Methods: Swiss male albino mice were exposed to the CUMS protocol daily for three consecutive weeks, resulting in depression-like behavioral symptoms. Imip

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Jodh, Rahul, Mukund Tawar, and Aparna Kachewar. "Evaluation of Antidepressant activity of Tricholepis glaberrima DC using various Paradigms." Research Journal of Pharmacy and Technology, December 24, 2022, 5610–16. http://dx.doi.org/10.52711/0974-360x.2022.00947.

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In the present experiment, Tricholepis glaberrima DC has been taken to study its antidepressant activity. The study was carried out in two different doses of the test drug. The animals were divided into 4 groups of 5 animals each, respectively. Mice in Group I (control) and II (standard) were administered distilled water, per oral and Imipramine 10mg/kg, per oral once respectively. Group III and IV were treated with the test drug METG in the dose of 100mg/kg and 300mg/kg, respectively. Findings of the test groups were compared with that of standard as well as plain control groups. In despair s

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Zadeh-Ardabili, Parastoo Mojtahed, Sima Kianpour Rad, Soheila Kianpour Rad, and Abolfazl Movafagh. "Antidepressant–like effects of fish, krill oils and Vit B12 against exposure to stress environment in mice models: current status and pilot study." Scientific Reports 9, no. 1 (2019). http://dx.doi.org/10.1038/s41598-019-56360-8.

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AbstractOxidative stress has significant role in pathophysiology of any kind of depression through actions of free radicals, non-radical molecules, and unbalancing antioxidant systems in body. In the current study, antidepressant responses of fish oil (FO), Neptune krill oil (NKO), vitamin B12 (Vit B12), and also imipramine (IMP) as the reference were studied. Natural light was employed to induce stress in the animals followed by oral administration of the drugs for 14 days. The antidepressant effect was assessed by tail suspension test (TST) and forced swimming test (FST), antioxidant enzymes

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Pojala, Kumar, and Vinay Sayeli. "An experimental study evaluating antidepressant activity of methanolic leaf and fruit pulp extracts of Aegle marmelos in Wistar rats." National Journal of Physiology, Pharmacy and Pharmacology, 2023, 1. http://dx.doi.org/10.5455/njppp.2023.13.12588202223122022.

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Background: Aegle marmelos (common name: Bel/wood apple/Tamil name: Vilvam/Telugu name: Sandiliyamu) has numerous therapeutic values in Indian traditional systems of medicine. The crude extracts of various parts of this plant have numerous properties including anti-inflammatory, antiulcer, antipyretic, and antioxidant. This study was taken to explore the antidepressant activity of A. marmelos. Aim and Objectives: The objectives of the study are as follows: (1) To identify the antidepressant activity of methanolic leaf and the fruit pulp extracts of A. marmelos. (2) To compare the dose-dependen

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Pannu, Arzoo, Ramesh K. Goyal, and Shikha Goswami. "Antidepressant Potential of Hispidulin Present in S. barbata D. Don: Mechanistic Insights through Neurochemical and Behavioral Assessments." Central Nervous System Agents in Medicinal Chemistry 25 (November 4, 2024). http://dx.doi.org/10.2174/0118715249331487241021053730.

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Background and Aim: This study aims to investigate the antidepressant properties of Hispidulin, a flavonoid present in Scutellaria barbata D. Don. The selection of Hispidulin stems from its notable inhibitory activity against Xanthine Oxidase (XO), a parameter in the pathophysiology of depression. Material and Methods: Mice were subjected to a rigorous evaluation using a murine model of Chronic Unpredictable Mild Stress (CUMS) to induce depression for 21 days and antidepressant properties were rigorously assessed using the Tail Suspension Test (TST), Forced Swim Test (FST), and Open Field Test

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Sharma, Abhishek, Rahul Singh, Shivkant Sharma, et al. "Cannabigerol and Cannabinoid Receptors in Major Depressive Disorder: Network Pharmacology, Molecular Docking, and In-vivo Analysis." Current Drug Discovery Technologies 22 (May 5, 2025). https://doi.org/10.2174/0115701638363093250324035540.

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Introduction: Cannabigerol (CBG), being one of the non-psychotropic phyto-cannabinoid, has been labelled and recognized to be antioxidant and neuroprotective; it may conceivably hold depression-relieving activity. Consequently, the objective of the present research procedure was to explore the depression-alleviating competence of cannabigerol in both stressed and unstressed mice using computational/in-silico modelling, followed by in-vivo analysis. Method: Target genes for Major Depressive Disorder (MDD) were identified using GeneCards and Swiss Target Prediction, with common targets screened

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Choudhary, Arbind Kumar, E. Manivannan, Kothai Ramalingam, V. Sivasankari, Arul Balasubramanian, and Chandrashekar Rajan. "Evaluation of The Antidepressant Properties of Aqueous Extract Terminalia Chebula Fruit Pulp in Wistar Albino Rats." International Journal of Life Science and Pharma Research, September 23, 2022, P162—P169. http://dx.doi.org/10.22376/ijpbs/lpr.2022.12.6.p162-169.

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Between 9 and 46% of those being treated for major depressive disorder had a partial or no response to antidepressants. Research is needed to produce a more effective and safer antidepressant. Terminalia chebula stimulates the CNS. The major goal of this research is to determine whether chronic administration of aqueous extract of Terminalia chebula fruit pulp dosages of (100, 200, and 400 mg/kg) have antidepressant effects. Terminalia chebula behavioural model of rats when supplied over three to four months in experimental rats. Wistar albino rats weighing 200 to 300 grams and one to two mont

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Momoh, Johnson Oshiobugie, and Taiwo Toyin Oshin. "Phytochemical Profiling Using GC-MS, Antioxidant and Antidepressant Properties of Methanolic Leaf Extract of Clerodendrum polycephalum Baker in Swiss Mice." International Research Journal of Pure and Applied Chemistry, March 2, 2023, 65–87. http://dx.doi.org/10.9734/irjpac/2023/v24i1802.

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Background: Clerodendrum polycephalum Baker is used by the traditional people in southwest Nigeria for arresting bleeding from cuts and treating bacterial infections especially wound infection without scientific proof of its efficacy. The plant was investigated in animal models for its antidepressant activity in Swiss mice. Methods: The GC-MS, phytochemical analyses, antioxidant activities, tail suspension test, forced swimming test and oxidative stress parameters were determined using standard procedures. Results: A total of 27 compounds were identified consisting of five prominen

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Hashemzaei, Mahmoud, Mina Abdollahzadeh, Mehrdad Iranshahi, Ebrahim Golmakani, Ramin Rezaee, and Kaveh Tabrizian. "Effects of luteolin and luteolin-morphine co-administration on acute and chronic pain and sciatic nerve ligated-induced neuropathy in mice." Journal of Complementary and Integrative Medicine 14, no. 1 (2017). http://dx.doi.org/10.1515/jcim-2016-0066.

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AbstractBackgroundNeuropathic pain (NP) is a common condition accompanied by nerve injury. To date, there is no definite treatment approved for this disorder. In addition, many drugs that are used for NP cause adverse reactions. Luteolin is a naturally occurring flavonoid with diverse pharmacological properties such as anti-inflammatory, antioxidant and anticancer. We sought to investigate luteolin effects on chronic, acute and neuropathic pain as well as its potential to increase morphine anti-nociceptive effects in mice.MethodsAlbino mice (20–25 g) were randomly divided into 14 groups (n=7)

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Pannu, Arzoo, and Ramesh K. Goyal. "Exploring the Antidepressant-like Effects of Wogonin: Analysis of Behavioural, Neurochemical, and Biochemical Parameters." Current Bioactive Compounds 21 (August 30, 2024). http://dx.doi.org/10.2174/0115734072312121240822050630.

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Background: Wogonin, a bioactive compound isolated from S. barbata D. Don, has been identified in the literature as a potential inhibitor of monoamine oxidase (MAO), a key enzyme involved in the degradation of neurotransmitters associated with mood regulation. This study aims to investigate the antidepressant-like activity of wogonin in vivo, utilizing a preclinical model. The rationale for selecting wogonin stems from its documented MAO inhibitory properties, suggesting a potential role in modulating neurotransmitter levels implicated in depressive disorder. Method: The study employs a multif

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Hamilton, Peter J., Emily Y. Chen, Vladimir Tolstikov, et al. "Chronic stress and antidepressant treatment alter purine metabolism and beta oxidation within mouse brain and serum." Scientific Reports 10, no. 1 (2020). http://dx.doi.org/10.1038/s41598-020-75114-5.

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Abstract Major depressive disorder (MDD) is a complex condition with unclear pathophysiology. Molecular disruptions within limbic brain regions and the periphery contribute to depression symptomatology and a more complete understanding the diversity of molecular changes that occur in these tissues may guide the development of more efficacious antidepressant treatments. Here, we utilized a mouse chronic social stress model for the study of MDD and performed metabolomic, lipidomic, and proteomic profiling on serum plus several brain regions (ventral hippocampus, nucleus accumbens, and medial pre

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Baron Flores, Veronica, E. Martínez-Rodríguez, D. Hernández-López, et al. "Efecto anticonvulsivo y antidepresivo del extracto etanólico de hojas de Annona reticulata en rata." Archivos de Neurociencias 26, no. 3 (2021). http://dx.doi.org/10.31157/an.v26i3.218.

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La depresión, la ansiedad y la epilepsia son afecciones del Sistema Nervioso Central (SNC) que causan sufrimiento y morbilidad entre la población mexicana. Si bien existen fármacos para su terapéutica, en ocasiones éstos resultan ineficaces y promueven efectos adversos que conllevan a la falta de apego por parte del paciente. Especies del género Annona son utilizadas en la medicina tradicional Mexicana por sus propiedades inhibitorias del SNC, de los cuales ya se han reportado sus propiedades como ansiolítico-sedantes y anticonvulsivos, además de sus propiedades como anticancerígenos, antioxid

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Baron Flores, Veronica, E. Martínez-Rodríguez, D. Hernández-López, et al. "Efecto anticonvulsivo y antidepresivo del extracto etanólico de hojas de Annona reticulata en rata." Archivos de Neurociencias 26, no. 3 (2021). http://dx.doi.org/10.31157/archneurosciencesmex.v26i3.218.

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La depresión, la ansiedad y la epilepsia son afecciones del Sistema Nervioso Central (SNC) que causan sufrimiento y morbilidad entre la población mexicana. Si bien existen fármacos para su terapéutica, en ocasiones éstos resultan ineficaces y promueven efectos adversos que conllevan a la falta de apego por parte del paciente. Especies del género Annona son utilizadas en la medicina tradicional Mexicana por sus propiedades inhibitorias del SNC, de los cuales ya se han reportado sus propiedades como ansiolítico-sedantes y anticonvulsivos, además de sus propiedades como anticancerígenos, antioxid

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