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Journal articles on the topic 'Imipramine HCL'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Hiwse, Ravindra, Rajat Pawar, and Sunita Patidar. "Formulation and Evaluation of Fast Dissolving Film of Imipramine Hcl." International Journal of Pharmaceutical Sciences and Medicine 7, no. 1 (2022): 59–80. http://dx.doi.org/10.47760/ijpsm.2022.v07i01.003.

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This research work was aimed to provide faster onset of action of Imipramine Hcl (used for the treatment depression and bed wetting) by formulating its fast-dissolving film (FDF). Imipramine Hcl belongs to BCS I. The FDF of Imipramine Hcl was prepared by solvent casting method using HPMC (film forming agent), Glycerol (plasticizer), Citric acid (saliva stimulating agent), Mannitol (sweetening agent). The formulation was optimized by two factors, three levels (32) was used for the formulation optimization of fast dissolving film of Imipramine Hcl and experimental trials are performed on all 9 f

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2

Larsen, Valdemar. "The Teratogenic Effects of Thalidomide, Imipramine HCl and Imipramine-N-Oxide HCl on White Danish Rabbits." Acta Pharmacologica et Toxicologica 20, no. 3 (2009): 186–200. http://dx.doi.org/10.1111/j.1600-0773.1963.tb01736.x.

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3

Rajani B K, P. Ashok kumar, and Suresh V Kulkarn. "Design and characterization of fast dissolving buccal film of imipramine HCL." World Journal of Advanced Research and Reviews 16, no. 2 (2022): 258–70. http://dx.doi.org/10.30574/wjarr.2022.16.2.1044.

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In depressed individuals, Imipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Imipramine hydrochloride having variable bioavailability i.e. ranging from 29-77% due to first pass metabolism, peak plasma concentration is usually attained 2-6 hours. Absorption is unaffected by food. It is freely soluble in water. The objective of this research work is to improve the bioavailability of the drug and fast the onset of action to decrease the depressant activity. The Buccal bioavailability of Imipramine HCL is only 29-77% for this reason dr

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4

Rajani, B. K., Ashok kumar P., and V. Kulkarn Suresh. "Design and characterization of fast dissolving buccal film of imipramine HCL." World Journal of Advanced Research and Reviews 16, no. 2 (2022): 258–70. https://doi.org/10.5281/zenodo.7785159.

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In depressed individuals, Imipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Imipramine hydrochloride having variable bioavailability i.e. ranging from 29-77% due to first pass metabolism, peak plasma concentration is usually attained 2-6 hours. Absorption is unaffected by food. It is freely soluble in water. The objective of this research work is to improve the bioavailability of the drug and fast the onset of action to decrease the depressant activity. The Buccal bioavailability of Imipramine HCL is only 29-77% for this reason dr

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5

Patel, Sejal K., and Natvarlal J. Patel. "Simultaneous Determination of Imipramine Hydrochloride and Chlordiazepoxide in Pharmaceutical Preparations by Spectrophotometric, RP-HPLC, and HPTLC Methods." Journal of AOAC INTERNATIONAL 93, no. 3 (2010): 904–10. http://dx.doi.org/10.1093/jaoac/93.3.904.

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Abstract A binary mixture of imipramine HCl and chlordiazepoxide was determined by three different methods. The first involved determination of imipramine HCl and chlordiazepoxide using the first derivative spectrophotometric technique at 219 and 231.5 nm over the concentration ranges of 120 and 224 g/mL with mean accuracies of 99.47 0.78 and 101.43 1.20, respectively. The second method utilized RP-HPLC with methanolacetonitrile0.065 M ammonium acetate buffer (45 + 25 + 30, v/v/v, pH adjusted to 5.6 0.02 with phosphoric acid) as the mobile phase pumped at a flow rate of 1.0 mL/min. Quantificat

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6

Jara-Morante, Eliana, David Suleiman, and L. Antonio Estévez. "Solubilities of Imipramine HCl in Supercritical Carbon Dioxide." Industrial & Engineering Chemistry Research 42, no. 8 (2003): 1821–23. http://dx.doi.org/10.1021/ie0109105.

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7

Mishra, Soumya, Nidhi Bais, and Sachin Kumar Jain. "Formulation and Evaluation of Mouth Dissolving Film of Imipramine HCL." Journal of Biomedical and Pharmaceutical Research 12, no. 4 (2023): 22–29. http://dx.doi.org/10.32553/jbpr.v12i4.1015.

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The main objective of the present study outlines a systematic approach for Design and Evaluation of Fast Dissolving Oral Films of Imipramine HCl to enhance the therapeutic efficacy and provide rapid onset of action in patients suffering from depression Because of patient may have trouble in swallowing a tablet or capsules. Mouth dissolving film is the most advanced oral solid dosage form due to its flexibility and comfort in use. Mouth dissolving films are oral solid dosage form that disintegrate and dissolve within a minute when placed in mouth without taking water or chewing. This dosage for

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8

Rubin, Ami-Hai E., Gideon G. Alroy, Ron Peled, and Peretz Lavie. "Preliminary Clinical Experience with Imipramine HCl n the Treatment of Sleep Apnea Syndrome." European Neurology 25, no. 2 (1986): 81–85. http://dx.doi.org/10.1159/000115991.

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9

Hejaz Azmi, Syed Najmul, Manal Khalifa Al-Hattali , Ruiyah Khalifa Al-Hinai , and Ibtihal Mohammed Al-Ajm. "A new spectrofluorimetric approach for the quantitation of imipramine HCl in commercial dosage forms." Journal of Advanced Pharmaceutical Science And Technology 1, no. 3 (2017): 29–48. http://dx.doi.org/10.14302/issn.2328-0182.japst-17-1714.

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10

Zhang, Danhui, Jacob Strock, and Joseph Sherma. "Transfer of TLC screening methods for azithromycin, imipramine HCl, and sulfadoxine + pyrimethamine tablets to quantitative HPTLC-densitometry methods." Journal of Liquid Chromatography & Related Technologies 39, no. 5-6 (2016): 277–80. http://dx.doi.org/10.1080/10826076.2016.1163465.

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11

Jun Nakamura, Takehiko Anraku, Muneyasu Shirouzu, Yoshifumi Iwashita, and Yoichi Nakazawa. "Effects of indeloxazine HCl on kindled amygdaloid seizures in rats: Comparison with the effects of phenytoin, diazepam, ethanol, and imipramine." Pharmacology Biochemistry and Behavior 45, no. 2 (1993): 445–50. http://dx.doi.org/10.1016/0091-3057(93)90263-s.

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12

Peselow, Eric D., Michael Stanley, Ann-Marie Filippi, Faouzia Barouche, Paul Goodnick, and Ronald R. Fieve. "The Predictive Value of the Dexamethasone Suppression Test." British Journal of Psychiatry 155, no. 05 (1989): 667–72. http://dx.doi.org/10.1192/s0007125000018171.

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We evaluated the dexamethasone suppression test (DST) as a predictor of response to drugs and placebo in 105 patients, in a large double-blind placebo-controlled out-patient trial to determine the efficacy of paroxetine HCI, a selective serotonin reuptake inhibitor, compared with that of imipramine HCI and placebo. The presence of a positive or negative DST did not predict response to either paroxetine or imipramine. However, a positive DST predicted a poorer response to placebo: only 3 out of 18 patients who showed DST non-suppression responded to placebo, as opposed to 11 out of 21 who exhib

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13

Peselow, Eric D., Michael Stanley, Ann-Marie Filippi, Faouzia Barouche, Paul Goodnick, and Ronald R. Fieve. "The Predictive Value of the Dexamethasone Suppression Test." British Journal of Psychiatry 155, no. 5 (1989): 667–72. http://dx.doi.org/10.1192/bjp.155.5.667.

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We evaluated the dexamethasone suppression test (DST) as a predictor of response to drugs and placebo in 105 patients, in a large double-blind placebo-controlled out-patient trial to determine the efficacy of paroxetine HCI, a selective serotonin reuptake inhibitor, compared with that of imipramine HCI and placebo. The presence of a positive or negative DST did not predict response to either paroxetine or imipramine. However, a positive DST predicted a poorer response to placebo: only 3 out of 18 patients who showed DST non-suppression responded to placebo, as opposed to 11 out of 21 who exhib

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14

Khan, Islam Ullah, Tehseen Aman, Asrar A. Kazi, and Rubina Azizuddin. "Spectrophotometric Determination of Imipramine-HCI in Pure and Pharmaceutical Preparations." Analytical Letters 32, no. 10 (1999): 2061–69. http://dx.doi.org/10.1080/00032719908542952.

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15

Rawat, Alisha, Meenakshi Sajwan, Yamini Chandola, Himani Nautiyal, and Nidhi Nainwal. "ENHANCED ANTICANCER POTENTIAL OF IMIPRAMINE IN CONJUGATION WITH NIACIN IN DENA INDUCED HEPATOCELLULAR CARCINOMA." Indian Drugs 59, no. 07 (2022): 65–71. http://dx.doi.org/10.53879/id.59.07.13073.

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Hepatocellular carcinoma (HCC) is constantly seeking the interest of researchers as an untreatable and fatal disease, attaining second position so far worldwide. Our study provides us an opportunity to explore new potential therapeutic combinations in this regard. We hypothesized that the anticancer activity of imipramine, which is used as an antidepressant drug, can be potentiated with an adjuvant, niacin, thereby providing a better treatment approach. The combination turned out to show beneficial alterations in various liver function test, caspase 3 (antiapoptotic) activity, tumor growth and

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16

Qu, Wanwan, Idrees B. Qader, and Andrew P. Abbott. "Controlled release of pharmaceutical agents using eutectic modified gelatin." Drug Delivery and Translational Research, May 8, 2021. http://dx.doi.org/10.1007/s13346-021-00998-3.

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AbstractDeep eutectic solvent (DES) is a class of ionic liquids, consisting of a mixture generally formed by combining hydrogen bond donors (HBDs) such as alcohols, amides and carboxylic acids with various quaternary ammonium salts. The decrease in melting points of the constituents is due to the charge delocalization during formation of hydrogen bonding between the hydrogen bond acceptor with the hydrogen bond donor. This can be considered one of the main reasons for increasing solubility and absorption of DESs. Most active pharmaceutical ingredients (APIs) have polar functional groups contai

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17

Jadhav, Ashwini, Sunil G. Shingade, Prachita Gauns Dessai, Bheemanagouda S. Biradar, and Shivalingrao MamleDesai. "Design, Docking, Characterisation, and Synthesis of Pyrimidine Derivatives for Antidepressant Activity." Current Drug Discovery Technologies 20 (October 5, 2023). http://dx.doi.org/10.2174/0115701638243835230925161546.

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Background: According to the report, in 2022, the prevalence rate of depression in India was 4.50%, and the cases stood at 56,675,969. The development of antidepressant agents has reduced the number of depressant and suicidal cases. Many researchers have found that pyrimidine possesses antidepressant activity. With this background, we thought of synthesizing pyrimidine derivatives. Objective: The objective of this study is to carry out molecular docking, synthesis, characterization, and evaluation of 2-((4,6-diphenylpyrimidin-2-yl)oxy)-N-phenylacetamide derivatives (17-26) as in vivo antidepre

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