Relevant bibliographies by topics / Immediate release tablets

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Immediate release tablets'

Author: Grafiati
Published: 9 March 2023
Last updated: 12 June 2025

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Journal articles on the topic "Immediate release tablets"

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Karim, Samira, Mohiuddin Ahmed Bhuiyan, and Md Sohel Rana. "Formulation and in vitro Evaluation of Glimepiride Sustained Release Tablets: Comparison with Immediate Release Tablets." Bangladesh Pharmaceutical Journal 18, no. 2 (2015): 157–62. http://dx.doi.org/10.3329/bpj.v18i2.24315.

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This work aims at the design of a sustained release formulation of glimepiride which is currently available in the treatment of type 2 diabetes mellitus and to investigate the effect of polymers on the release profile of glimepiride. Glimepiride sustained release tablets were prepared by direct compression method using different ratios of various release retarding polymers such as carbopol, ethyl cellulose, methocel K4 MCR, methocel K15 MCR, methocel K100 MCR and xanthum gum. These formulations were also compared with glimepiride immediate release tablets. The prepared tablets were subjected to various physical parameter tests including weight variation, friability, hardness, thickness, diameter, etc. In vitro dissolution studies of the formulations were done at pH 6.8 in phosphate buffer using USP apparatus 2 (paddle method) at 50 rpm. The percent releases of all the formulations (30) were 73.11%- 98.76% after 8 hours. The release pattern followed zero order kinetics and the release of the drug was hindered by the polymers used in the study. On the other hand, 100% drug was released within 1 hour from the immediate release tablet of glimepiride. The study reveals that the polymers used have the capacity to retard the release of the drug from the sustained release tablets and the more is the amount of the polymer in the formulation the less is the release of drug showing more retardation of drug release.Bangladesh Pharmaceutical Journal 18(2): 157-162, 2015
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Swetanshu, ,., and Vijay Sharma. "Formulation, Optimization and Evaluation of Bilayer Tablet of Antihypertensive Drug." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 704–8. http://dx.doi.org/10.22270/jddt.v9i4.3098.

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Hypertension or high blood pressure occurs when the high cardiac output exerts pressure on the arterial wall as the blood flow increases. Bi-layer tablets are prepared with one layer of drug for immediate release while second layer designed to release drug later, either as second dose or in an extended release manner. Bi-layered tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances, and also for sustained release tablet in which one layer is immediate release as initial dose and second layer is maintenance dose. Bilayer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet in which one Layer is immediate release as initial dose and second layer is maintenance dose. The preparation of tablets in the form of multi layers is used to provide systems for the administration of drugs.
 Keywords: Hypertension, Bi-layered tablet, Enalapril, Immediate release and Sustained release.
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Dong, Runqiao, James C. DiNunzio, Brian P. Regler, Walter Wasylaschuk, Adam Socia, and J. Axel Zeitler. "Insights into the Control of Drug Release from Complex Immediate Release Formulations." Pharmaceutics 13, no. 7 (2021): 933. http://dx.doi.org/10.3390/pharmaceutics13070933.

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The kinetics of water transport into tablets, and how it can be controlled by the formulation as well as the tablet microstructure, are of central importance in order to design and control the dissolution and drug release process, especially for immediate release tablets. This research employed terahertz pulsed imaging to measure the process of water penetrating through tablets using a flow cell. Tablets were prepared over a range of porosity between 10% to 20%. The formulations consist of two drugs (MK-8408: ruzasvir as a spray dried intermediate, and MK-3682: uprifosbuvir as a crystalline drug substance) and NaCl (0% to 20%) at varying levels of concentrations as well as other excipients. A power-law model is found to fit the liquid penetration exceptionally well (average R2>0.995). For each formulation, the rate of water penetration, extent of swelling and the USP dissolution rate were compared. A factorial analysis then revealed that the tablet porosity was the dominating factor for both liquid penetration and dissolution. NaCl more significantly influenced liquid penetration due to osmotic driving force as well as gelling suppression, but there appears to be little difference when NaCl loading in the formulation increases from 5% to 10%. The level of spray dried intermediate was observed to further limit the release of API in dissolution.
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Jange, Camila G., Carl R. Wassgren, and Kingsly Ambrose. "The Significance of Tablet Internal Structure on Disintegration and Dissolution of Immediate-Release Formulas: A Review." Powders 2, no. 1 (2023): 99–123. http://dx.doi.org/10.3390/powders2010008.

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The internal microstructure of a tablet, such as pore geometry, formulation properties, and compact strength, impacts the tablet’s disintegration kinetics. Ideally, one could design the microstructure to control dissolution onset and therapeutical performance of immediate-release formulas; however, manufacturing tablets with a desired microstructure can be challenging due to the interplay between formulation and process parameters. Direct quantification of tablet microstructure can provide a framework for optimizing composition and process parameters based on a Quality-by-Design approach. This article reviews the importance of tablet microstructure design and liquid transport kinetics to help optimize the release and dissolution profiles of immediate-release products. Additionally, the formulation and process parameters influencing the tablet microstructure and liquid transport kinetics are discussed.
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Ramu Samineni, Jithendra Chimakurthy, Sathish Kumar Konidala, Udayaratna K, Devatulasi K, and Ager Dengoc. "Effect of Hydroxypropyl Methylcellulose and Microcrystalline Cellulose in Design and Optimization of Nebivolol Hydrochloride Immediate Release Tablets by Response Surface Methodology." International Journal of Research in Pharmaceutical Sciences 12, no. 3 (2021): 1990–98. http://dx.doi.org/10.26452/ijrps.v12i3.4806.

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The goal of the research is to design and optimize Nebivolol Hydrochloride immediate-release tablet using response surface methodology. Nebivolol Hydrochloride immediate-release tablets used in the treatment of heart attacks, myocardial infarction. Response surface methodology calculations for this optimization study were performed utilizing Minitab 17. Different formulations of immediate-release were prepared by applying 2 factors 3 levels full factorial design using Minitab 17, which gave 9 formulations by using the wet granulation method. Independent variables like the amount of hydroxypropyl methylcellulose (X1), and microcrystalline cellulose (X2) and dependent variables like the per cent drug release at 45 minutes (Y1), disintegration (Y2) were selected for optimization. The prepared batches of Nebivolol Hydrochloride immediate-release tablets were evaluated for the pre-compression and post-compression parameters like weight variation, thickness, hardness, and friability, disintegration, and in-vitro drug release studies. All the Physico-chemical parameters were found satisfactory for prepared tablets. The optimized formulation F7 showed disintegrated in 83 sec, percentage dissolution release 97.85 at the end of 45th minute. The results shows that formulated immediate-release tablets of Nebivolol HCl were better to meet patient compliance with respect to effectiveness.
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Singh, Neha, Durga Pandey, Nilesh Jain, and Surendra Jain. "Formulation and In Vitro Evaluation of Bilayer Tablets of Lansoprazole and Amoxycillin Trihydrate for the Treatment of Peptic Ulcer." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 23–31. http://dx.doi.org/10.22270/jddt.v11i1.4481.

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The present work involves the formulation development, optimization and In-vitro evaluation of bilayer tablet containing Lansoprazole in the immediate release layer and Amoxycillin in the sustained release layer, using sodium starch glycolate as a super disintegrant for the immediate release layer and the hydrophilic matrix HPMC K100M, hydrophobic matrix Ethyl cellulose are used in the sustained release layer. Bilayer tablet showed as initial burst effect to provide dose of immediate release layer Lansoprazole to control the acid secretion level and the sustained release of Amoxycillin for 24 hours. Immediate and sustained release tablets were formulated by wet granulation method because of the poor flow property of the blends. The prepared bilayer tablet was evaluated for their precompression parameters, physical characteristics like hardness, friability, uniformity of weight, uniformity of drug content, swelling index, In-vitro floating studies and In-vitro drug release. The release of the lansoprazole from the immediate release layer was found to be 97.46 ± 0.15% in 15minutes. The release of Amoxycillin Trihydrate for the sustained release floating layer was found to be 98.25 ± 0.14% in 12 hours. Lansoprazole potentiate the effect of Amoxycillin. Hence the bilayer tablets of Lansoprazole and Amoxycillin were used to improve patient compliance towards the effective management of ulcer.
 Keywords: bilayer tablet, Lansoprazole, and Amoxycillin, sustained release
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Hussain, Shaik Md Zakir, J. Shiva, Goli Venkateswarlu, D. Suthakaran, and Syed Ghouse. "Formulation and Evaluation of Ritonavir Immediate Release Tablets by Hot Melt Extrusion Method." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 63–71. http://dx.doi.org/10.22270/jddt.v9i4-a.3293.

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In the present work, an attempt has been made to develop immediate release coated tablets of Ritonavir by hot met extrusion method using 16 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as bulk density, tapped density. The prepared IR coated tablets of ritonavir shown good post compression parameters. They passed all the quality control evaluation parameters as per USP limits. Among all the formulations, F5 formulation showed maximum % drug release i.e., 99 % in 120 mins hence it is considered as optimized formulation. The optimized formulation was compared to innovator tablets.
 Keywords: Ritonavir, HPMC, Ethyl cellulose, Copovidone immediate release tablets.
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Reddy, P. Srikanth, V. Alagarsamy, P. Subhash Chandra Bose, V. Sruthi, and D. Saritha. "DESIGN AND CHARACTERIZATION OF NATEGLINIDE ORAL DISPERSIBLE TABLETS BY SOLID DISPERSION TECHNIQUE." International Journal of Research in Ayurveda and Pharmacy 13, no. 04 (2022): 72–77. http://dx.doi.org/10.7897/2277-4343.130491.

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An ideal dosage regimen in the drug therapy of any disease is the one which immediately attains the desired therapeutic concentration of drug in plasma and maintains it constant for the entire duration of treatment. The main objective of the present work is to investigate the possibility of obtaining an immediate release tablet of Nateglinide with improved dissolution using the Solid dispersion technique. Solid dispersions preparations containing different weight ratios of Nateglinide in PEG6000 (1:1, 1:3, 1:5) were prepared by the melting method and characterized for drug content, phase solubility study, and dissolution study. Immediate release tablets were prepared using various polymers, and the prepared tablets were evaluated for weight variation, friability, assay, hardness, thickness, disintegration test and dissolution test. The Nateglinide immediate release tablet (F2) showed 58.72% drug release within the first 5 min. and 99.50% drug release within 30 min. The results showed that the formulation satisfied the objective of fast disintegration, dissolution, % friability, hardness, wetting time, water absorption ratio, ease of administration and safety. The success of the present study recommends a detailed investigation into in-vivo studies for its effective use in clinical practice.
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Molavi, Fatima, Hamed Hamishehkar, and Ali Nokhodchi. "Impact of Tablet Shape on Drug Dissolution Rate Through Immediate Released Tablets." Advanced Pharmaceutical Bulletin 10, no. 4 (2020): 656–61. http://dx.doi.org/10.34172/apb.2020.079.

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Purpose : The aim of this study was to evaluate the influence of the geometric shape on the dissolution rate of the domperidone, a drug model for immediate release dosage form. In this regard, a lack of sufficient information about the effective dissolution rate of the drugs regarding their shapes has made this issue an interesting subject for researchers. Methods: For this purpose, three tablet shapes, namely flat and biconvex both in a round and oblong shapes, with different four sizes were modelled for the preparation of domperidone tablet. In vitro dissolution test was accomplished using a USP dissolution apparatus II. The drug dissolution rate was assessed by calculating various dissolution parameters; e.g., dissolution efficiency (DE), mean dissolution rate (MDR), mean dissolution time (MDT), and difference and similarity factors (f1 and f2 ). Results: Regarding the disintegration time, the larger tablets showed a faster disintegration time. When the size of the tablets was smaller, the amount of released drug was significantly decreased. In addition, #9 tablets with a flat or biconvex geometry had obvious effects on the DE values. Generally, biconvex tablets had higher DE percentage than the flat tablets. Conclusion: Noticeable differences in dissolution parameters by considering the different geometric shapes play an important role in the drug release kinetics which makes a significant effect on quick onset of action in oral administration.
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Mangilal, Teelavath, and Shiva Kumar Y. "Formulation and In Vitro Evaluation of Bilayered Matrix Tablets of Pioglitazone for Immediate Release and Glimepiride for Extended Release." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 6 (2018): 4348–54. http://dx.doi.org/10.37285/ijpsn.2018.11.6.8.

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Bi-layer tablets are novel drug delivery systems where a combination of two or more drugs in a single unit having different release profiles which improves patient compliance and prolongs the drug action. The study was performed to design bilayer matrix tablets of pioglitazone for immediate release and glimepiride for extended release delivery system. Bilayered matrix tablets composed of two layers, one is immediate release and a second layer is extended release layers. The immediate release layer comprised sodium starch glycolate, and croscarmellose sodium as super disintegrates and extended release layer comprised ethyl cellulose and HPMC K4M as release retardant polymers. Direct compression method was employed for the formulation of bilayer tablets. In vitro studies have shown more than 80% of pioglitazone was released within 60 min. Ethyl cellulose and HPMC K4M retarded the release of glimepiride from the controlled release layer for 12 h. Drug release mechanism exponent (n) was determined for all formulations (0.689-0.789). The release of pioglitazone was found to follow a first order release and the release of glimepiride was followed zero order release model.
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Dissertations / Theses on the topic "Immediate release tablets"

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Solik, Agnieszka Anna [Verfasser]. "Formulation Development of High Dose (-)-Epigallocatechin-3-gallate Immediate Release Tablets / Agnieszka Anna Solik." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1070218944/34.

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Kindgen, Sarah M. [Verfasser]. "Hydrodynamics and solid dosage form disintegration/dissolution : immediate release tablets and novel in situ polyelectrolyte gastroretentive drug delivery systems / Sarah M. Kindgen." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2015. http://d-nb.info/1225749581/34.

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Melocchi, A. "INJECTION MOLDING/MICROMOLDING APPLICATIONS TO DRUG DELIVERY." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/251825.

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In the present work the application potential of injection molding (IM) and micromolding (µIM) for the manufacturing of drug products was investigated. These techniques are largely employed in the plastics industry to process thermoplastic polymers into objects with different size, shape and possibly many details, and they could offer several advantages in the pharmaceutical area, mainly related to versatility, patentability, scalability and production costs (continuous manufacturing). Processes and equipment generally employed as well as current pharmaceutical applications already proposed in the literature were preliminarily reviewed. Drug delivery systems (DDSs) in the form of gastro-resistant containers based on HPMCAS were afterwards designed and manufactured by µIM. Notably, such DDSs represent a step forward in the field as they may provide a ready-to-use alternative to enteric-coated dosage forms. Moreover, the feasibility by hot-processing techniques (hot melt extrusion and IM) of prolonged-release hydrophilic matrices and immediate release tablets was demonstrated, which could help promoting the use of continuous manufacturing in the pharmaceutical production areas.
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Zaheer, Kamran [Verfasser]. "Evaluation of formulation and processing factors on the disintegration and dissolution of immediate release tablets in fed state : formulation strategy towards minimizing viscosity mediated negative food effect / Kamran Zaheer." Mainz : Universitätsbibliothek Mainz, 2018. http://d-nb.info/1159797374/34.

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Kuo, Ming-shin, and 郭明欣. "A Study on the Formulation of Immediate Release Cisapride Tablet." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/93766166583951314823.

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碩士<br>高雄醫學院<br>藥學研究所<br>86<br>The present study was carried out in three parts. Firstly, to determine the solubility of cisapride powder in various pH value of media at three different temperatures. The effects of various surfactants on the solubility of the powder were also studied. A reliable HPLC method for the determination of cisapride concentration in solution was established.The evaluation on the commercial products, cisapride tablets, was the second part. Two generic tablets which were bioequivalent to the innovator's product were studied for the general tablet properties, such as disintegration time, hardness, friability, thickness, diameter, uniformity of dosage units ( weight variation and content uniformity ) and dissolution profile, then compared to those of the innovator's product. The storage effects on these properties were also determined.In the third part, the effects of various disintegrants, disintegrant concentration and diluents on the physical properties （disintegration time, hardness, friability, thickness and diameter） and the release of cisapride tablet were determined. A 23 full factorial design of experiments was employed to evaluate the effects of the three factors on the percentage release of cisapride；the subsequent data was compared using analysis of variance ( ANOVA ). Furthermore, the physical properties and dissolution pIt was found that cisapride powder dissolved freely in 0.1N HCl and pH4.5 acetate buffer, respectively but not in pH6.8 phosphate buffer. The solubility of cisapride powder was increased by adding a surfactant to the latter medium. Sodium lauryl sulfate was found to be the most effective one. Temperature would have a greater influence on the solubility of the cisapride powder for the lower pH medium.The SUPAC-IR method showed that no similarity was found between the innovator's product and the two respective generic products as the ?2 values were smaller than 50.After storage for three months at three different temperatures, the content of the subsequent cisapride powder was decreased. The most serious reduction was obtained at the highest temperature, 60℃. A higher storage temperature also showed a more significant effect on the properties of the commercial cisapride tablets.Both the dissolution rate and amount release were poor for cisapride tablets using either lactose or Emcompress per se as the diluent. However, incorporation of a disintegrant in the tablet formulation would markly increase the dissolution rate as well as the percentage release of cisapride.The experimental design study illustrated that the kinds of disintegrants, the concentration of disintegrant and the kinds of diluents had significant effects on the release percentage of cisapride determined in two minutes, but had no significant interaction between them.A cross-over comparison between the dissolution profiles of the formulated cisapride tablets and the three commercial products using the SUPAC-IR method produced some informative results.
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Shao, Qun, Raymond C. Rowe, and Peter York. "Comparison of neurofuzzy logic and neural networks in modelling experimental data of an immediate release tablet formulation." 2009. http://hdl.handle.net/10454/2998.

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No<br>This study compares the performance of neurofuzzy logic and neural networks using two software packages (INForm and FormRules) in generating predictive models for a published database for an immediate release tablet formulation. Both approaches were successful in developing good predictive models for tablet tensile strength and drug dissolution profiles. While neural networks demonstrated a slightly superior capability in predicting unseen data, neurofuzzy logic had the added advantage of generating rule sets representing the cause-effect relationships contained in the experimental data.
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Shao, Qun, Raymond C. Rowe, and Peter York. "Investigation of an artificial intelligence technology- model trees Novel applications for an immediate release tablet formulation database." 2009. http://hdl.handle.net/10454/3051.

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No<br>This study has investigated an artificial intelligence technology ¿ model trees ¿ as a modelling tool applied to an immediate release tablet formulation database. The modelling performance was compared with artificial neural networks that have been well established and widely applied in the pharmaceutical product formulation fields. The predictability of generated models was validated on unseen data and judged by correlation coefficient R2. Output from the model tree analyses produced multivariate linear equations which predicted tablet tensile strength, disintegration time, and drug dissolution profiles of similar quality to neural network models. However, additional and valuable knowledge hidden in the formulation database was extracted from these equations. It is concluded that, as a transparent technology, model trees are useful tools to formulators
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Book chapters on the topic "Immediate release tablets"

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Polli, James E. "in Vitro-in Vivo Relationships of Several “Immediate” Release Tablets Containing a Low Permeability Drug." In Advances in Experimental Medicine and Biology. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4684-6036-0_17.

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Zeiss, Daniel Horst, and Linda Amundstuen. "Information Regarding Modification of Oral Solid Medicines in Written Drug Information: Potential Consequences for Patient Safety." In Medication Safety in Municipal Health and Care Services. Cappelen Damm Akademisk/NOASP, 2022. http://dx.doi.org/10.23865/noasp.172.ch5.

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Oral solid medicines (oral solid dosage forms, OSDFs) are among the most used medications, and have various pharmaceutical designs ranging from relatively simple uncoated tablets with immediate-release properties, to advanced modified-release preparations slowly releasing the active ingredient. Taking medicines correctly is essential to preserve intended effects and avoid adverse effects. Still, modification of OSDFs is a common practice among patients and health care personnel, due to for example, swallowing difficulties. Modifications such as crushing tablets and opening capsules should only be done with a careful assessment of potential risks and benefits. In this study, we systematically reviewed the information relating to modification of OSDFs in the monographs of a commonly used source of medicine information in Norway, Felleskatalogen®. A total of 31 different OSDFs were identified. Results show that information on whether the medicines should be swallowed whole, could be divided, crushed, chewed, or opened, varied widely. Medicines with modified-release characteristic generally had more and stricter recommendations concerning modification than medicines with immediate-release characteristic. Recommendations varied largely between monographs, and different recommendations such as “shall”, “should” or “must” may be interpreted differently among readers. Furthermore, a relatively small proportion of the monographs contained descriptions of the potential consequences of modification. Based on our observations, a necessary risk-benefit assessment on dosage form manipulation for health care personnel and patients is possibly being impeded. Explicit and unambiguous information, or the development and implementation of a “traffic light model” for dosage form manipulation might reduce the risk of medication errors, and thereby increase patient safety.
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Ahlskog, J. Eric. "Unstable Responses and Dyskinesias: Later Motor Problems." In Dementia with Lewy Body and Parkinson's Disease Patients. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199977567.003.0014.

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Chapter 6 outlined the symptoms that should benefit from carbidopa/levodopa treatment and how to initiate it. Once the optimum dosing scheme has been established there usually is not much medication adjustment required for the initial few years. However, this situation changes with longer durations of DLB or Parkinson’s disease. During the first several years of DLB or Parkinson’s disease, treatment with carbidopa/levodopa is straightforward—the responses are stable and unchanging over the course of the day. Thus, the exact time a person takes the doses is not important as long as they are administered on an empty stomach (at least 1 hour before and 2 hours after meals). If the dosage is changed, it takes about a week for the response to fully develop. This pattern of a stable levodopa response that slowly accumulates over a week is termed the long-duration response. For this response to fully develop and capture the maximum benefit, about six to eight tablets of the regular (immediate-release) carbidopa/levodopa 25/100 tablets per day are necessary. While this has not been well studied in clinical trials, experience in the clinic suggests that this is approximately correct. After a few years of having DLB or Parkinson’s disease, the person’s response to levodopa tends to change. The long-duration effect persists, but part of the benefit becomes time-locked to each dose. This response does not reflect how long the person has been taking carbidopa/levodopa but how long he or she has had DLB or Parkinson’s disease. As these conditions progress, the capacity to maintain a stable, around-the-clock effect from levodopa diminishes, as if the effect could no longer be stored-up. This is not simply a brain levodopa storage problem, but it behaves that way. People with this time-locked benefit from levodopa will note that their gait, stiffness, tremor, and slowness will improve an hour or so after taking a carbidopa/levodopa dose. In other words, it takes about an hour (sometimes less) for the regular carbidopa/levodopa to “kick in.” Initially, this benefit may last 4 to 5 hours, but after many years it may diminish to 2 hours or less.
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Chalortham, Nopphadol, Taneth Ruangrajitpakorn, Thepchai Supnithi, and Phuriwat Leesawat. "OXPIRT: Ontology-based eXpert system for Production of a generic Immediate Release Tablet." In Formulation Tools for Pharmaceutical Development. Elsevier, 2013. http://dx.doi.org/10.1533/9781908818508.203.

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Conference papers on the topic "Immediate release tablets"

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Máthé, Rita, Tibor Casian, and Ioan Tomuță. "Multivariate modelling for investigating the impact of raw materials and process variability on high drug load immediate release tablets obtained through wet granulation." In II. Symposium of Young Researchers on Pharmaceutical Technology,Biotechnology and Regulatory Science. Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy, 2020. http://dx.doi.org/10.14232/syrptbrs.2020.op27.

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