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Relevant bibliographies by topics / Immortalisation

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Dissertations / Theses

Academic literature on the topic 'Immortalisation'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 May 2024

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Dissertations / Theses on the topic "Immortalisation"

1

Seow, Choon Sheong. "Analysis of gene expression in tumour immortalisation." Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251848.

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Cellular senescence is an irreversible growth-arrested state seen in primary human cells after a finite number of cell divisions both in culture and <i>in vivo</i>. The escape from senescence to immortalisation is often thought to be a prerequisite for carcinogenesis. Many changes in senescent cells are consistent with changes in tissue and organ function with age. I used serial analysis of gene expression (SAGE) to analyse global gene expression profiles in senescent and early passage human foetal fibroblasts (hff). A total of over 20,000 SAGE tags were sequenced and characterised, correspond

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2

Wen, Victoria Wei-Yu Women's &amp Children's Health Faculty of Medicine UNSW. "Molecular alterations during immortalisation of human endothelial cells." Awarded by:University of New South Wales. Women's & Children's Health, 2009. http://handle.unsw.edu.au/1959.4/44743.

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Replicative exhaustion of endothelial cells (ECs) contributes to the pathogenesis of age-related vascular disorders, including atherosclerosis and impaired wound healing. Conversely, abnormal proliferation of ECs underlies the development of EC-derived malignancies, such as haemangioblastoma and angiosarcoma. The central objective of this thesis was to delineate mechanisms that regulate the replicative lifespan of human ECs and molecular alterations that occur during immortalisation of ECs. The gradual shortening of telomeres (chromosome-end structures) is one mechanism that restricts the repl

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3

Grix, Nicola. "Conditional immortalisation of mouse auditory sensory epithelial cells." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414134.

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4

Linne, Hannah Louise. "Investigating telomerase regulation in human breast cancer cells : a search for telomerase repressor sequences localised to chromosome 3P." Thesis, Brunel University, 2015. http://bura.brunel.ac.uk/handle/2438/11620.

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Cellular immortality is one of the ten hallmarks of human cancer and has been shown to be an essential prerequisite for malignant progression (Hanahan and Weinberg., 2011, Newbold et al., 1982, Newbold and Overell., 1983). In contrast, normal human somatic cells proliferate for a limited number of population doublings before entering permanent growth arrest known as replicative senescence. This is thought to be due to the progressive shortening of telomeric sequences with each round of cell division. Over 90% of human tumours, but not the majority of human somatic cells, have been found to exp

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5

Kan, Chin-Yi. "Human Papillomavirus in human breast cancer and cellular immortalisation." Sydney : University of New South Wales. Biotechnology and Biomolecular Sciences, 2007. http://www.library.unsw.edu.au/~thesis/adt-NUN/public/adt-NUN20071004.080541/.

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6

McDonald, Jacqueline. "Conditional immortalisation of myeloid-precursors to model innate immunity." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/45729/.

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The prevalence of fungal infections is on the rise due to the increase of immune suppressed individuals. Neutrophils are key immune cells in the fight against fungal infections. The study of neutrophil biology is hampered by the short lived nature of the cells and the fact that they cannot be easily genetically modified. In this thesis, I generate and characterise myeloid precursor cell lines that can be genetically manipulated and differentiated into functional neutrophils. These in vitro generated neutrophils were adoptively transferred into live animals and tracked during inflammatory respo

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7

Flanagan, James Michael. "The immortalisation of B-lymphocytes with Epstein-Barr virus /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16501.pdf.

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8

Kohli, Jaskaren Singh. "Senescence and immortalisation in melanoma progression and multiple primary melanoma." Thesis, St George's, University of London, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706529.

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Multiple primary melanoma is defined as the gain of at least one additional independent melanoma and occurs in approximately 5% of melanoma patients. Germline mutations can be identified in genes in these patients, which are known to, or are predicted to result in an extension of melanocyte lifespan e.g. pl6, CDK4, and components of the telomere shelterin cap. We therefore hypothesised that 'normal' melanocytes from pl6 and CDK4 wild-type multiple primary melanoma patients have a statistically longer lifespan compared to those from single primary melanoma patients. Melanocytes from multiple pr

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9

Zwermann, Birgit. "Die Rolle der Telomerase in der Immortalisation und malignen Transformation von Nebennierenrindenzellen." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-145498.

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10

Whitaker, Noel James. "Involvement of p53 and RB-1 in the immortalisation of human cells." Thesis, The University of Sydney, 1995. https://hdl.handle.net/2123/27505.

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Normal diploid mammalian cells undergo a finite number of population doublings in culture before they undergo senescence [Hayflick & Moorhead, 1961]. In contrast, tumours often contain "immortalised" cells that exhibit an apparently unlimited in vitro and in vivo proliferative potential. Fusion of normal and immortalised cells usually results in hybrids with limited proliferative potential [Bunn & Tarrant, 1980; Muggleton-Harris & DeSimone, 1980] indicating that immortalisation is probably due to loss of normal gene function. Similarly, fusion of different immortalised human cell lines with ea

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