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Journal articles on the topic 'Immun javob'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Ahmedova, Saodat Toshboltayevna, Mohinur Normurod qizi Aminova, and Gulnora Karim qizi Mardonqulova. "INSON ORGANIZMIDA IMMUN SISTEMANING TUTGAN O'RNI, VAZIFASI VA O'ZIGA XOS XUSUSIYATLARI." GOLDEN BRAIN 1, no. 2 (2023): 101–5. https://doi.org/10.5281/zenodo.7555494.

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<em>Immun sistemasi </em><em>organizmni</em><em> </em><em>kasalliklardan</em><em> himoya qiluvchi biologik jarayonlar tarmogʻidir. U </em><em>viruslardan</em><em> tortib </em><em>parazit chuvalchanglarga</em><em> qadar turli xil patogenlar, shuningdek, saraton hujayralari, hatto yogʻoch qirindilarigacha taniydi, ularga immunologik javob qaytaradi va ularni organizm sogʻlom </em><em>toʻqimalaridan</em><em> ajratib turadi. Koʻpgina biologik turlarda immun sistemasi ikkita asosiy kichik guruhdan iborat. Tugʻma immun sistemasi xilma-xil holatlar va taʼs

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To'ychiyev, H.H, and S.Ch. Eshkaraev. "REVMATIZM KASALLIKLARINING KELIB CHIQISH SABABLARI VA DAVOLASH USULLARI." MEDICINE, PEDAGOGY AND TECHNOLOGY: THEORY AND PRACTICE 2, no. 8 (2024): 91–96. https://doi.org/10.5281/zenodo.14601186.

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Ushbu maqolada revmatizm kasalliklarining asosiy etiologik omillari, klinik ko‘rinishlari, diagnostika usullari va zamonaviy davolash strategiyalari haqida batafsil ma’lumot beriladi. Revmatizm asosan autoimmun jarayonlar bilan bog‘liq bo‘lib, organizmning o‘z to‘qimalariga hujum qiluvchi immun javob natijasida rivojlanadi. Kasallik bo‘g‘imlar, yurak va boshqa muhim organlarning shikastlanishiga olib kelishi mumkin. Ushbu maqolada kasallikni samarali nazorat qilish usullari, oldini olish choralari va bemorlar uchun tavsiyalar muhokama qilingan.

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Abdullayeva, R.O, and N.I Tursunova. "ENDOMETRIAL STROMAL SARKOMALARNING GETEROGENLIGI VA O'SIMTA MIKRO-MUHITINING TERAPEVTIK JAVOBGA TA'SIRI." Multidisciplinary Journal of Science and Technology 5, no. 5 (2025): 1205–9. https://doi.org/10.5281/zenodo.15532041.

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Endometrial stromal sarkoma (ESS) bachadonning kam uchraydigan malign o‘smalaridan biri bo‘lib, uning molekulyar va gistologik xilma-xilligi davolash natijalariga sezilarli ta’sir ko‘rsatadi. Ushbu kasallikning heterogen tabiati individual davolash strategiyalarini ishlab chiqishni qiyinlashtiradi. Tadqiqot ESSning molekulyar geterogenligi va o‘simta mikro-muhitining (TME) terapevtik javobga ta’sirini o‘rganadi. JAZF1-SUZ12 va YWHAE-NUTM2B kabi genetik translokatsiyalar o‘simtaning klinik kechishi, o‘sish tezligi va davolashga chidamliligin

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Ziyodullayeva, Iroda. ""Shegellalar – dizenteriya qo'zg'atuvchisi"." MULTIDISCIPLINARY JOURNAL: FUNDAMENTAL RESEARCH SCIENTIFIC JOURNAL 1, no. 4 (2025): 106–11. https://doi.org/10.5281/zenodo.15344811.

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Ushbu maqolada dizenteriya kasalligining asosiy etiologik omili bo‘lgan Shigella turkumiga mansub bakteriyalar — shegellalarning morfologik, biologik va epidemiologik xususiyatlari tahlil qilingan. Maqolada shegellalarning inson organizmiga kirish yo‘llari, ularning patogenlik mexanizmlari, shuningdek, immunologik javob va organizmda yuzaga keladigan o‘zgarishlar ilmiy asosda yoritilgan. Shuningdek, dizenteriyaning klinik belgilari, diagnostika usullari va zamonaviy davolash choralari haqida ma’lumot berilgan. Antibiotiklarga nisbatan rivojlanayotgan rezistentlik

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Bhandari, Ashish, Michael F. Cuccarese, Kevin Fales, et al. "Abstract 1888: Identification and optimization of novel small molecule modulators of immune checkpoint resistance with a unified representation space for genomic and chemical perturbations." Cancer Research 82, no. 12_Supplement (2022): 1888. http://dx.doi.org/10.1158/1538-7445.am2022-1888.

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Abstract Immune checkpoint inhibitors have revolutionized cancer treatment, producing a durable response consistent with immunologic memory in a subset of patients. However, the majority of patients demonstrate innate or acquired resistance that must be characterized and overcome to induce successful treatment. Advancements in human reverse translation and scaled in vivo CRISPR screening have uncovered novel molecular and genomic correlates of resistance, and promising druggable mechanisms - driven by highly complex interactions between tumor cells and the immune system. It is this core biolog

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Negandhi, Priyanka, Amol Andhale, Sourya Acharya, Faizan Khan, and Tushar Patil. "Creutzfeldt-Jakob disease − A case report." International Journal of Nutrition, Pharmacology, Neurological Diseases 15, no. 1 (2025): 112–17. https://doi.org/10.4103/ijnpnd.ijnpnd_154_24.

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Creutzfeldt-Jakob disease (CJD) is a brain disorder that causes dementia. It forms part of a set of animal and human diseases called prion disorders. Symptoms of Creutzfeldt-Jakob disease can resemble those of Alzheimer’s disease. This disease is always fatal, and most patients do not survive beyond a year. Myoclonus, vision problems, brain and pyramidal/extrapyramidal symptoms, and changes in cognitive function and cognitive abilities are seen as manifestations. We present a case of a 65-year-old woman complaining of rapidly progressive dementia, which was followed by the slowness of movement

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Bui, Esther, Eric Ehrensperger, Demetrios J. Sahlas, et al. "Inflammatory Cerebrospinal Fluid in Sporadic Creutzfeldt-Jakob Disease." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 35, no. 5 (2008): 625–29. http://dx.doi.org/10.1017/s0317167100009422.

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Background:Sporadic Creutzfeldt-Jakob disease (CJD) is a fatal, transmissible spongiform encephalopathy characterized by rapidly progressive dementia, myoclonus, ataxia and akinetic mutism. The underlying mechanism is believed to be a conformational change of a native prion protein which characteristically fails to provoke an immune response. Commensurate with the latter, cerebrospinal fluid (CSF) classically exhibits a non-inflammatory profile.Cases:We report two patients with pathologically-proven sporadic CJD presenting with a significant CSF pleocytosis.Conclusion:Although uncommon, the pr

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Milroy, A. M., E. Bouzamondo, H. J. Ralston III, S. B. Prusiner, and S. J. DeArmond. "The Plain and the Ugly Prion Infected Neuronal Tissue in an Experimental Animal Model; An Electron Microscopic Study." Microscopy and Microanalysis 6, S2 (2000): 646–47. http://dx.doi.org/10.1017/s1431927600035728.

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Transmissible encephalopathy of animals (scrapie and bovine spongiform encephalopathy) and of man (Creutzfeldt-Jacob disease, new variant Creutzfeldt-Jacob disease, Kuru, Gerstmann-Straussler-Scheinker disease and familial fatal insomnia) have been well characterized as progressive neurodegenerative diseases, often associated with spongiform degeneration, neuronal loss, reactive astrocytic gliosis and variable amyloid plaques, without any sign of an immune response or inflammatory infiltrates. Prion proteins are elements that propagate variability through multiple biologically active conformer

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Patel, Bhavika, Stephanie Allen, Brenna Dennison, et al. "Abstract 6666: Multispectral imaging to detect immune phenotypes in pre and post therapy breast cancer patient specimens." Cancer Research 83, no. 7_Supplement (2023): 6666. http://dx.doi.org/10.1158/1538-7445.am2023-6666.

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Abstract The immune microenvironment is an important component in cancer therapy. Immune cells can encourage tumor growth, leading to disease progression. A high number of immune cells may be predictive of disease prognosis and response to therapies. Therefore, understanding the immune cell phenotypes present within cancerous tissue can be valuable in developing strategies that aid in the treatment of cancer. In this study, we analyzed pre-and post-therapy samples from breast cancer patients, treated with neoadjuvant chemotherapy, using a 6-plex immunofluorescence assay which included clinical

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Beretta, Simone, Andrea Stabile, Claudia Balducci, et al. "COVID‐19‐associated immune‐mediated encephalitis mimicking acute‐onset Creutzfeldt‐Jakob disease." Annals of Clinical and Translational Neurology 8, no. 12 (2021): 2314–18. http://dx.doi.org/10.1002/acn3.51479.

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Au, Yu-Wah, David Satijn, Martin Mehnert, et al. "Abstract 3974: Discovery and validation of therapeutic targets in immune cells by mass spectrometry-based proteomics." Cancer Research 83, no. 7_Supplement (2023): 3974. http://dx.doi.org/10.1158/1538-7445.am2023-3974.

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Abstract Immuno-oncology (IO) has substantially improved the survival of cancer patients over the past several years encouraging the discovery of novel IO targets which are typically proteins expressed on the surface of immune cells. Sensitive quantification of proteins in complex biological samples is routinely achieved by immunoassays that use antibodies specific to target proteins. Such approaches can be a limitation in IO drug discovery and development as de novo development of antibodies is associated with long lead times, high costs, and high failure rates. Protein quantification using m

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Wu, Jinchun, Xianyu Liu, Yanhua Mou, et al. "Low TWEAK expression indicates poor survival and is correlated with sparse TIICs in lung adenocarcinoma (LUAD)." Journal of Clinical Oncology 38, no. 15_suppl (2020): e21017-e21017. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e21017.

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e21017 Background: Lung adenocarcinoma (LUAD) occupies the most of non-small cell lung cancer (NSCLC) and shows promising response to PD-1 immunotherapy, but immune escape will cause treatment failure indicating poor prognosis. TWEAK (Tumor necrosis factor-related weak inducer of apoptosis, also known as TNFSF12) combining with its receptor FN14 (fibroblast growth factor–inducible 14) mediates crucial innate and adaptive immune pathways to promote the progression of multiple autoimmune diseases. So we assumed that TWEAK is a prognostic predictor and related with tumor-infiltrating immune cells

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Schaefer, Rachel, Linying Liu, Michael McLane, et al. "Abstract 1726: Novel, high-throughput multiplexed immunofluorescence staining method for assessing spatial relationships of immuno-oncology biomarkers in whole slide FFPE tissue." Cancer Research 82, no. 12_Supplement (2022): 1726. http://dx.doi.org/10.1158/1538-7445.am2022-1726.

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Abstract As cancer research has progressed, the role of the immune system in tumor development has been discovered to be increasingly more important. There is a need to explore the spatial relationships between tumor and immune cells in tissue to help better predict therapeutic treatment outcomes in patients in the growing field of immuno-oncology. We have developed a new single cell multiplexed immunofluorescence staining method along with our patented multi-spectral imaging (MSI) technology to allow scientists to detect up to six biomarkers simultaneously on one tissue section, which provide

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Assis-de-Lemos, Gabriela, Rayanne Moura-do-Nascimento, Manuela Amaral-do-Nascimento, Ana C. Miceli, and Tuane C. R. G. Vieira. "Interactions between Cytokines and the Pathogenesis of Prion Diseases: Insights and Implications." Brain Sciences 14, no. 5 (2024): 413. http://dx.doi.org/10.3390/brainsci14050413.

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Transmissible Spongiform Encephalopathies (TSEs), including prion diseases such as Bovine Spongiform Encephalopathy (Mad Cow Disease) and variant Creutzfeldt–Jakob Disease, pose unique challenges to the scientific and medical communities due to their infectious nature, neurodegenerative effects, and the absence of a cure. Central to the progression of TSEs is the conversion of the normal cellular prion protein (PrPC) into its infectious scrapie form (PrPSc), leading to neurodegeneration through a complex interplay involving the immune system. This review elucidates the current understanding of

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Manuelidis, Laura, Igor Zaitsev, Pandelakis Koni, Zhi Yun Lu, Richard A. Flavell, and William Fritch. "Follicular Dendritic Cells and Dissemination of Creutzfeldt-Jakob Disease." Journal of Virology 74, no. 18 (2000): 8614–22. http://dx.doi.org/10.1128/jvi.74.18.8614-8622.2000.

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ABSTRACT The contribution of immune system cells to the propagation of transmissible encephalopathies is not well understood. To determine how follicular dendritic cells (FDC) may act, we challenged lymphotoxin β null and wild-type (wt) controls with a Creutzfeldt-Jakob disease (CJD) agent. There was only a small difference in incubation time to clinical disease even after peripheral challenge with low infectious doses (31 in a total of 410 days). Brain pathology with extensive microglial infiltration, identified by keratan sulfate, as well as astrocytic hypertrophy, was also equivalent in all

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Tsou, Adam, Po-Jui Chen, Kuo-Wang Tsai, Wan-Chung Hu та Kuo-Cheng Lu. "THαβ Immunological Pathway as Protective Immune Response against Prion Diseases: An Insight for Prion Infection Therapy". Viruses 14, № 2 (2022): 408. http://dx.doi.org/10.3390/v14020408.

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Prion diseases, including Creutzfeldt–Jakob disease, are mediated by transmissible proteinaceous pathogens. Pathological changes indicative of neuro-degeneration have been observed in the brains of affected patients. Simultaneously, microglial activation, along with the upregulation of pro-inflammatory cytokines, including IL-1 or TNF-α, have also been observed in brain tissue of these patients. Consequently, pro-inflammatory cytokines are thought to be involved in the pathogenesis of these diseases. Accelerated prion infections have been seen in interleukin-10 knockout mice, and type 1 interf

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Lyman, Melissa R., Jacob T. Mitchell, Luciane T. Kagohara, et al. "Abstract 2873: Evolution of immune cell composition and functionality as pancreatic intraepithelial neoplasia progresses to pancreatic ductal adenocarcinoma." Cancer Research 83, no. 7_Supplement (2023): 2873. http://dx.doi.org/10.1158/1538-7445.am2023-2873.

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Abstract Pancreatic ductal adenocarcinoma (PDAC) is most often diagnosed at an advanced stage. Newly diagnosed patients therefore have a dismal five-year survival rate of 11%. However, PDAC progresses from pre-invasive pancreatic intraepithelial neoplasia (PanIN) over at least a decade. Throughout this transition, the tissue microenvironment becomes increasingly immunosuppressive. Early PanINs may therefore be more amenable to immune-based interception strategies; however, little is known about the pre-malignant lesion immune microenvironment in PDAC. We hypothesized that the identification of

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许, 崇彦. "A Mendelian Randomization Study on the Causal Relationship between Immune Cells and Sporadic Creutzfeldt-Jakob Disease." Hans Journal of Biomedicine 14, no. 04 (2024): 624–36. http://dx.doi.org/10.12677/hjbm.2024.144068.

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Lee, Jacob S., Pamela Toy, Gundula Min-Oo, et al. "Abstract 3517: Pharmacologic inhibition of HPK1 kinase activity enhances immune cell activation and T cell mediated anti-tumor activity." Cancer Research 82, no. 12_Supplement (2022): 3517. http://dx.doi.org/10.1158/1538-7445.am2022-3517.

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Abstract Hematopoietic progenitor kinase 1 (HPK1, mitogen-activated kinase kinase kinase kinase 1 [MAP4K1]), a cytosolic STE20 ser/thr kinase from the germinal center family of kinases, regulates the function of diverse immune populations including T cells, B cells, and dendritic cells. In T cells, activated HPK1 regulates T cell receptor (TCR) signaling by phosphorylating the adaptor protein SLP76 on Ser376, which induces the association of SLP76 with 14-3-3 proteins. This SLP76/14-3-3 complex leads to its disassociation from the TCR signalosome, resulting in reduced downstream TCR signaling.

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Ciolac, Dumitru, Renata Racila, Carolina Duarte, et al. "Clinical and Radiological Deterioration in a Case of Creutzfeldt–Jakob Disease following SARS-CoV-2 Infection: Hints to Accelerated Age-Dependent Neurodegeneration." Biomedicines 9, no. 11 (2021): 1730. http://dx.doi.org/10.3390/biomedicines9111730.

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Systemic inflammation and the host immune responses associated with certain viral infections may accelerate the rate of neurodegeneration in patients with Creutzfeldt–Jakob disease (CJD), a rare, transmissible neurodegenerative disease. However, the effects of the newly emerged SARS-CoV-2 infection on the pathogenesis of CJD are unknown. In this study, we describe the case of an elderly female patient with sporadic CJD that exhibited clinical deterioration with the emergence of seizures and radiological neurodegenerative progression following an infection with SARS-CoV-2 and severe COVID-19. D

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Friedman-Levi, Yael, Orli Binyamin, Kati Frid, Haim Ovadia, and Ruth Gabizon. "Genetic prion disease: no role for the immune system in disease pathogenesis?" Human Molecular Genetics 23, no. 15 (2014): 4134–41. http://dx.doi.org/10.1093/hmg/ddu134.

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Prion diseases, which can manifest by transmissible, sporadic or genetic etiologies, share several common features, such as a fatal neurodegenerative outcome and the aberrant accumulation of proteinase K (PK)-resistant PrP forms in the CNS. In infectious prion diseases, such as scrapie in mice, prions first replicate in immune organs, then invade the CNS via ascending peripheral tracts, finally causing death. Accelerated neuroinvasion and death occurs when activated prion-infected immune cells infiltrate into the CNS, as is the case for scrapie-infected mice induced for experimental autoimmune

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Herszterg, Sophie, Gustavo Arango-Argoty, and Etai Jacob. "Abstract 5025: Applying deep learning transformers and expression quantitative trait loci to interrogate immunogenetic determinants of cancer risk." Cancer Research 85, no. 8_Supplement_1 (2025): 5025. https://doi.org/10.1158/1538-7445.am2025-5025.

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Abstract The immune system plays a pivotal role in suppressing cancer development through a process known as cancer immunosurveillance. However, substantial immune variation among healthy individuals suggests that the effectiveness of the immune system in eliminating cancer is very likely to vary. This study aims to identify genetic immune characteristics that either protect against or increase cancer risk and to understand how these immune factors interact with known environmental and lifestyle-related risk factors. &#x2028; To achieve this, we have employed a deep learning approach, leve

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Pagano, Nathan, Gerard Aguilar Perez, Rolando Garcia-Milian, and Laura Manuelidis. "Proliferative arrest induces neuronal differentiation and innate immune responses in normal and Creutzfeldt-Jakob Disease agent (CJ) infected rat septal neurons." PLOS One 20, no. 5 (2025): e0323825. https://doi.org/10.1371/journal.pone.0323825.

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Rat post-mitotic septal neurons, engineered to reversibly proliferate and arrest under physiological conditions, can be maintained for weeks without cytotoxic effects. Nine representative independent cDNA libraries were made to evaluate global arrest-induced neural differentiation and innate immune responses, e.g., upregulated interferon (β-IFN) RNA, that were previously identified in normal uninfected and Creutzfeldt-Jakob Disease agent (CJ) infected septal neurons. This reversible cell model encompassed a non-productive latent (CJ−) and a highly infectious (CJ + , 10 logs/gm) state. Arrest o

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Darragh, Laurel B., Jacob Gadwa, Keara Boss, and Sana D. Karam. "Abstract IA05: Nodal and systemic Immune effects of radiation in HNSCC." Clinical Cancer Research 29, no. 18_Supplement (2023): IA05. http://dx.doi.org/10.1158/1557-3265.aacrahns23-ia05.

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Abstract When combined with immunotherapy, HPV-unrelated HNSCC has a high incidence of local and regional recurrence. Since nodal metastasis remains a common pattern of spread for HNSCC, elective nodal irradiation (ENI) is commonly employed to eradicate potential microscopic disease in non-involved lymph nodes. Given our developing understanding that (1) immune cells are highly radio-sensitive, and (2) that anti-tumor T cell priming, and expansion, occur in the draining lymph nodes (DLNs), we tested whether RT directed at gross tumor only could increase the effectiveness of immunotherapies. Us

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Nehete, Pramod N., Sriram Chitta, Bharti P. Nehete, Lawrence E. Williams, Thomas Wisniewski та Henrieta Scholtzova. "Plasmacytoid dendritic cells (pDCs) and IFN-α production in aged squirrel monkeys (Saimiri boliviensis boliviensis) stimulated with Class C CpG Oligodeoxynucleotides". Journal of Immunology 204, № 1_Supplement (2020): 148.13. http://dx.doi.org/10.4049/jimmunol.204.supp.148.13.

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Abstract Synthetic CpG oligodeoxynucleotides (ODNs) with defined CpG motifs and immunomodulatory properties signal through an endosomal membrane-based type of pattern recognition receptor (PRR), the Toll-like receptor 9 (TLR9), that has been identified in dendritic cells (DCs), B cells, and other human immune cell types. CpG-ODNs influence several signaling pathways, leading to cytokine production in many mammalian species that make CpG ODNs suitable as therapeutic interventions in a variety of human disease conditions. The squirrel monkey (SQM), a well-established New World non-human primate

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Lima, Svetlana Ferreira, Lasha Gogokhia, Monica Viladomiu, et al. "Transferable Immune Reactive Microbiota Determine Clinical and Immunologic Outcome of FMT in UC." Journal of Immunology 204, no. 1_Supplement (2020): 237.14. http://dx.doi.org/10.4049/jimmunol.204.supp.237.14.

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Abstract Background Over two million people worldwide suffer from ulcerative colitis (UC). Biologic therapy has significantly improved treatment, but nearly two-thirds of patients attenuate response. Fecal microbiota transplant (FMT) is an emerging therapy for the treatment of UC, but the microbial mechanism responsible for clinical response is poorly understood. Using samples from our pilot FMT study (Jacob V, et al 2017), we aim to define the core transferable microbiota (CTM) in UC patients responsive to FMT therapy and its therapeutic mechanism. Methods IBD disease activity scores were use

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Stevens, E. Andrew, Alexander K. Powers, Thomas A. Sweasey, Stephen B. Tatter, and Robert G. Ojemann. "Simplified harvest of autologous pericranium for duraplasty in Chiari malformation Type I." Journal of Neurosurgery: Spine 11, no. 1 (2009): 80–83. http://dx.doi.org/10.3171/2009.3.spine08196.

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The authors describe a method of harvesting autologous pericranium for duraplasty in patients with Chiari malformation Type I (CM-I) that avoids excessive exposure or a second incision. Nonautologous dural grafts have been associated with numerous complications including hemorrhage, bacteria and virus transmission, fatal Creutzfeldt-Jakob disease transmission, foreign body reaction, systemic immune response, excessive scarring, slower healing, premature graft dissolution, and wound dehiscence. Autogenous tissues have the advantage of being nonimmunogenic, nontoxic, readily available, and inexp

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Bennett, Kaila M., Jacob P. Matson, Sylwia Stopka, et al. "Abstract 6161: Exploring BRG399, a novel microtubule-binding agent, as an inducer of immunogenic cell death in cancer therapy." Cancer Research 85, no. 8_Supplement_1 (2025): 6161. https://doi.org/10.1158/1538-7445.am2025-6161.

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Abstract Cancer therapy is transforming from traditional chemotherapeutic agents (CTAs) to innovative immunotherapies. Despite this shift, chemotherapy remains clinically stable, as CTAs are thought to convert the tumor microenvironment (TME) from immunosuppressive to immune-active by inducing immunogenic cell death (ICD) in tumor cells which leads to stimulation of immune cells. This ICD induction is thought to be crucial for enhancing the efficacy of immunotherapies. Thus, using CTAs as ICD agents—alone or in combination with immunotherapies—may offer significant anti-cancer benefits and new

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Callan, Torrington, and Stephen Woodcock. "Stochastic modelling of chlamydial infections." ANZIAM Journal 61 (July 6, 2020): C89—C103. http://dx.doi.org/10.21914/anziamj.v61i0.15159.

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Chlamydia trachomatis is a bacterial pathogen that can cause serious reproductive harm. We describe a class of stochastic branching processes and their application in modelling the growth of an infection by Chlamydia. Using simulations we show that the model can reproduce biological phenomena of interest, and we show the variability in outcomes of infections under the same parameter conditions. We further speculate how this model might be used to explain long-term adverse reproductive sequelae. References Y. M. AbdelRahman and R. J. Belland. The chlamydial developmental cycle. FEMS Microbio. R

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Svensson, Maja, Alexandra Petersson, Viktor Sincic, et al. "Abstract A022: Effects of chemotherapy on the peripheral immune-cellome in patients with pancreatic cancer." Cancer Research 82, no. 10_Supplement (2022): A022. http://dx.doi.org/10.1158/1538-7445.evodyn22-a022.

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Abstract Pancreatic cancer (PC) has become one of the leading causes of cancer related deaths. Late detection and resistance to therapy are two reasons for the dismal prognosis of this disease. Hence, there is an immense need for novel treatment options as well as predictive biomarkers, to prolong the life of these patients. The Chemotherapy, Host Response and Molecular Dynamics in Periampullary Cancer, the CHAMP study (clinical trial nr NCT03724994), is an ongoing observational, prospective clinical study that includes newly diagnosed patients with PC or other periampullary cancers receiving

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Ma, Liqian, Jacob Pfeil, Hin-Ching Lo, et al. "Abstract A099: The IO-Atlas Project: A cross-cohort tumor immunophenotyping platform enhancing precision immuno-oncology." Cancer Immunology Research 13, no. 2_Supplement (2025): A099. https://doi.org/10.1158/2326-6074.io2025-a099.

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Abstract The tumor microenvironment (TME) is complex and significantly influences how patients respond to immunotherapy. Despite decades of research generating numerous gene signatures to describe the TME, there is no consensus on the best way to capture meaningful variation, as the commonly used gene signatures are heavily T cell-biased with high degrees of collinearity. To better understand TME dynamics and represent them consistently and interpretably, we developed a framework for immunophenotyping using disparate immuno-oncology (IO) transcriptional “fingerprints” as part of the AbbVie IO

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Navarro, Fabio, Eric Levy, Pamela Milani, et al. "Abstract 5021: Accurate quantification of infiltrating B cell composition and clone diversity in tumor samples." Cancer Research 82, no. 12_Supplement (2022): 5021. http://dx.doi.org/10.1158/1538-7445.am2022-5021.

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Abstract Tumors harbor a complex ecosystem of malignant, immune, and stromal cells. While malignant cells dictate much of the tumor biology, there is evidence that the tumor microenvironment (TME) also plays a major role in disease etiology. Given the complexity and abundance of the TME cellular composition, investigating the role of immune cell types will yield novel biomarkers for tumor progression and response to therapies. The role of B cells as a prognostic biomarker remains elusive. For instance, infiltrating B cells in CRC have both positive and negative prognostic value. Thus, a scalab

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Josef, Finsterer, and A. Scorza MD Fulvio. "Do Not Diagnose Creutzfeldt - Jakob disease Based Solely on Clinical Exam, Imaging, and Elevated 14-3-3 in Times of COVID-19." Sarcouncil Journal of Medicine and Surgery 3, no. 3 (2024): 1–2. https://doi.org/10.5281/zenodo.10802045.

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We read with interest Pandey <em>et al</em>’s. article on a 61 year-old male with Alice in Wonderland syndrome attributed to Creutzfeldt-Jacob disease (CJD) [Pandey, S. <em>et al</em>., 2023]. The patient initially suffered from micropsia, macropsia, hyperchromatopsia, and difficulty assessing depth while walking. Workup revealed hemianopsia to the left, gait disturbance, short-term memory loss, stereotyped, abnormal right upper extremity movements (repetitive combing movements), diffusion-weighted imaging (DWI) hyperintensity along the fronto-parieto-occipital cortex, sharp waves at irr

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Hirschhorn, Daniel, Lukas Kraehenbuehl, Sadna Budhu, et al. "Abstract 4052: Neutrophil recruitment and activation promotes cutaneous adverse effects with T cell immunotherapies." Cancer Research 84, no. 6_Supplement (2024): 4052. http://dx.doi.org/10.1158/1538-7445.am2024-4052.

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Abstract Immune-based therapies that induce tumor regression are often accompanied by immune-related adverse events (irAEs) which can occasionally present with severe and lethal symptoms. Currently, there are no well-defined preventative approaches to uncouple anti-tumor immunity from irAEs. Currently approved immunotherapies include agents that activate T cell responses, such as antibodies blocking immune checkpoints and infusion of tumor-derived, T cell receptor-transgenic or chimeric antigen receptor-modified T cells. While the beneficial and toxic effects of T cell-based therapies in the c

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Sinha, Surajit, Abir Panda, Zeribe Nwosu, et al. "Abstract C106: IMPACT restrains immuno-metabolic GCN1 signaling to govern pancreatic cancer metastasis." Cancer Research 84, no. 2_Supplement (2024): C106. http://dx.doi.org/10.1158/1538-7445.panca2023-c106.

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Abstract Introduction: Metastatic outgrowth and colonization requires that disseminated tumor cells simultaneously compensate for alterations in nutrient availability, counteract oxidative stress, and evade host innate and adaptive immune surveillance. The mechanistic underpinnings of how these vital processes are coordinated is not understood. Experimental procedures: Using intrasplenic injection (liver metastases) and tail vein injection (lung metastases), we employed a gain-of-function cDNA screen in mice to identify regulators of colonization. In doing so, we identified GCN1 signaling as i

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Norek, Karen, Jacob Kennard, Kenneth Fuh, Robert Shepherd, Kristina Rinker, and Olesya Kharenko. "Abstract PO5-25-02: Microenvironment based co-culture dependence of breast cancer and immune cell interactions on functional outcomes." Cancer Research 84, no. 9_Supplement (2024): PO5–25–02—PO5–25–02. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-25-02.

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Abstract The tumour microenvironment (TME) includes physical forces from interstitial fluid flow and cell-cell interactions that modulate cancer development and progression through activation of multiple oncogenic pathways leading to tumor growth and metastatic spreading. We previously reported on the role of physical forces on epithelial to mesenchymal transition (EMT) and S100 gene family expression and cell to cell adhesion properties with implications to normal breast development and cancer. Signals from the tumor exit the local tumor environment through interstitial fluid transport and ce

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Tsao, Andrew, Xiaoyu Yang, Garrett Wong, et al. "Abstract 2753: Engineering patient-derived tumors to enable high-throughput screening: Immuno-oncology workflows." Cancer Research 83, no. 7_Supplement (2023): 2753. http://dx.doi.org/10.1158/1538-7445.am2023-2753.

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Abstract Aim/Introduction: In recent years, cancer immunotherapy has become one of the fastest-growing areas in cancer research. Selecting suitable and cost-effective experimental models for developing and validating immunotherapies is one of the major obstacles researchers face today. To overcome this, patient-derived tumor models are of increasing interest because they can better recapitulate many of the properties and the heterogeneity exhibited by the tumor microenvironment at a relatively low cost. Hereby, we propose a high throughput screening platform for an effective and efficient eval

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Dennison, Brenna, Stephanie Allen, Bhavika Patel, et al. "Abstract 2322: Precision immuno-oncology (IO) ISH/IF multiplex panel: Spatial detection of cytokines and IO biomarkers." Cancer Research 83, no. 7_Supplement (2023): 2322. http://dx.doi.org/10.1158/1538-7445.am2023-2322.

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Abstract Cytokines have a large impact on the tumor microenvironment by affecting cell growth, survival, inflammation, and differentiation. Understanding the spatial biology within the tumor microenvironment, including the cytokine organization within specific cell types, can lead to better treatment plans for patients. We developed a hybrid multiplex panel, using RNA in-situ hybridization (ISH) and immunofluorescence (IF) to investigate the spatial biology of the tumor microenvironment. This panel also enabled us to simultaneously detect the RNA of cytokines and protein of specific immuno-onc

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González-Sanmiguel, Juliana, Christina M. A. P. Schuh, Carola Muñoz-Montesino, Pamina Contreras-Kallens, Luis G. Aguayo, and Sebastian Aguayo. "Complex Interaction between Resident Microbiota and Misfolded Proteins: Role in Neuroinflammation and Neurodegeneration." Cells 9, no. 11 (2020): 2476. http://dx.doi.org/10.3390/cells9112476.

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Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Creutzfeldt–Jakob disease (CJD) are brain conditions affecting millions of people worldwide. These diseases are associated with the presence of amyloid-β (Aβ), alpha synuclein (α-Syn) and prion protein (PrP) depositions in the brain, respectively, which lead to synaptic disconnection and subsequent progressive neuronal death. Although considerable progress has been made in elucidating the pathogenesis of these diseases, the specific mechanisms of their origins remain largely unknown. A body of research su

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Weiss, Robin A. "The Leeuwenhoek Lecture 2001. Animal origins of human infectious disease." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 356, no. 1410 (2001): 957–77. http://dx.doi.org/10.1098/rstb.2001.0838.

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Since time immemorial animals have been a major source of human infectious disease. Certain infections like rabies are recognized as zoonoses caused in each case by direct animal–to–human transmission. Others like measles became independently sustained with the human population so that the causative virus has diverged from its animal progenitor. Recent examples of direct zoonoses are variant Creutzfeldt–Jakob disease arising from bovine spongiform encephalopathy, and the H5N1 avian influenza outbreak in Hong Kong. Epidemics of recent animal origin are the 1918–1919 influenza pandemic, and acqu

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Maini, Deepinder Kaur, Rahul Handa, Saurabh Arora, Rajiv Anand, and Varun Rehani. "Fluoro-deoxy glucose positron emission tomography brain as a potent marker for antibody-mediated neurodegeneration in dementia: A case report." Indian Journal of Case Reports 11, no. 5 (2025): 188–90. https://doi.org/10.32677/ijcr.v11i5.5029.

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Rapidly progressive dementia (RPD) is a subacute onset progressive disease with cognitive decline which can be associated with vascular, neurodegeneration (prion disease- Creutzfeldt-Jakob disease), inflammatory (immune-mediated or infection), or neoplastic causes. RPD can be fatal with high morbidity and mortality if diagnosis is delayed or misdiagnosed. Our aim is to understand the role and sensitivity of magnetic resonance imaging (MRI) brain versus Fluoro-deoxy glucose positron emission tomography (FDG PET) brain, for the diagnosis of paraneoplastic neurologic syndrome (PNS). We present th

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Traboulsi, Wael, Subhadip Kundu, Pankaj Gaur, et al. "Abstract LB339: PARP inhibition reprograms CD8 T cells, enhancing their function and generation of prolonged memory, leading to greater anti-tumor immune response." Cancer Research 83, no. 8_Supplement (2023): LB339. http://dx.doi.org/10.1158/1538-7445.am2023-lb339.

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Abstract Olaparib is the most widely studied third-generation PARP inhibitor (PARPi) in clinical practice with a significant clinical outcome in BRCA deficient tumors such as breast and ovarian cancers. However, innate and adaptive resistance in patients with DNA damage repair (DDR) gene mutations were reported after treatment with PARPi, highlighting the potential implication of other compartments such as the role of immune cells in the mechanism of resistance. Importantly, PARPi is shown to have an immune-modulatory capacity within the tumor microenvironment (TME) by activating the STING pat

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Stoeck, Katharina, and Inga Zerr. "Cellular immune activation markers neopterin and beta 2-microglobulin are not elevated in the cerebrospinal fluid of patients with Creutzfeldt–Jakob disease." Journal of Neuroimmunology 233, no. 1-2 (2011): 228–32. http://dx.doi.org/10.1016/j.jneuroim.2010.12.003.

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Chandra, Sadanandavalli Retnaswami, Lakshminarayanapuram Gopal Viswanathan, Anupama Ramakanth Pai, Rahul Wahatule, and Suvarna Alladi. "Syndromes of Rapidly Progressive Cognitive Decline-Our Experience." Journal of Neurosciences in Rural Practice 08, S 01 (2017): S66—S71. http://dx.doi.org/10.4103/jnrp.jnrp_100_17.

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ABSTRACT Background: Dementias are fairly slowly progressive degenerative diseases of brain for which treatment options are very less and carry a lot of burden on family and society. A small percentage of them are rapidly progressive and mostly carry a different course outcome. However, there are no definite criteria other than the time line for these patients. Aims: The aim of this was to identify and categorize the causes and course of rapidly progressive dementias seen in our center. Settings and Design: Patients who presented with rapid deterioration of cognitive functions within weeks to

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Lucien, Fabrice, Roxane Lavoie, Jack Korleski та ін. "Abstract B034: The immune checkpoint molecule B7-H3 is a driver of tumor immune exclusion by mediating TGF-β activation". Cancer Immunology Research 13, № 2_Supplement (2025): B034. https://doi.org/10.1158/2326-6074.io2025-b034.

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Abstract Addressing the limited responsiveness to immune checkpoint blockade (ICB) in human cancers remains a critical challenge. Efforts over the past two decades have primarily focused on enhancing CD8 T cell function and preventing their exhaustion. However, less attention has been given to understanding the molecular mechanisms that contribute to the immunosuppressive tumor microenvironment (TME), which impedes CD8 T cell infiltration and fosters ICB resistance. The TME in ICB-resistant tumors is characterized by Transforming Growth Factor beta (TGF-β) cytokine signaling, leading to a fibr

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Kennard, Jacob, Karen Norek, Kenneth Fuh, Robert D. Shepherd, Kristina D. Rinker, and Olesya A. Kharenko. "Abstract 5567: Breast cancer cell alteration of immune cell transcriptome through indirect communication." Cancer Research 84, no. 6_Supplement (2024): 5567. http://dx.doi.org/10.1158/1538-7445.am2024-5567.

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Abstract Crosstalk between tumor and non-tumor cells plays an important role in cancer progression and metastasis often leading to a modification of non-malignant cells into pro-oncogenic phenotypes. Understanding this process is important for diagnostic and therapeutic advances. We previously reported clinical validation results for a new way to detect early-stage breast cancer using a panel of RNA biomarkers from whole blood and a machine learning software-powered testing system. Recently, we showed that immune cells undergo transcriptomic and functional changes upon direct contact with brea

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Kolb, Joseph P., Kathryn R. Meshaw, Timothy Hutchinson, et al. "Abstract 2189: A spectral flow cytometry panel and workflow for the reproducible assessment of colorectral tumor immunophenotype in the context of immunotherapies." Cancer Research 85, no. 8_Supplement_1 (2025): 2189. https://doi.org/10.1158/1538-7445.am2025-2189.

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Multiparameter flow cytometry analysis of immune cells within solid tumors has provided insight into the mechanism of action of novel immunotherapies, but challenges exist regarding the interpretation of data stemming from variation in sample processing, selection of optimal combinations of fluorochrome-conjugated antibodies, and population gating strategy. Here we present a 20-color spectral flow cytometry backbone panel and gating scheme that can be applied to syngeneic colorectal tumor samples from different mouse strains with minimal manual adjustment. Using the CT26 and MC38 subcutaneous

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Santos, James Paul, Jacob Levy, Kristen Ruma, et al. "Abstract 1725: Tissue-based biomarker analysis of DLBCL using multiplex immunofluorescence AQUA (Automated Quantitative Analysis) algorithms." Cancer Research 82, no. 12_Supplement (2022): 1725. http://dx.doi.org/10.1158/1538-7445.am2022-1725.

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Abstract Purpose: Deeper understanding of immune landscape of DLBCL tumor microenvironment is critical for exploration and development of next generation immunotherapies. Although conventional immunohistochemical (IHC) analysis can provide information on the immune landscape or target expression, it is generally limited to single marker analysis. Advantages of multiplex fluorescence IHC (mFIHC) include the ability to assess different cell types, their spatial relationship as well as variable antigen expression on tumor cells. As such, we developed quantitative mFIHC panels using AQUA® (Automat

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Caksa, Signe, Nicole A. Wilski, Erica L. Kitterman, et al. "Abstract 1256: Transglutaminase-2 is elevated in the invasive cell state and modulates the tumor immune microenvironment in cutaneous melanoma." Cancer Research 83, no. 7_Supplement (2023): 1256. http://dx.doi.org/10.1158/1538-7445.am2023-1256.

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Abstract Cutaneous melanoma is the most fatal skin cancer; resistance to targeted therapies contributes to poor prognosis. In some cases, resistance arises from pre-existing tumor heterogeneity, which allows subpopulations of drug-tolerant cells with distinct transcriptional states to survive in the presence of drug. The loss of SOX10, a lineage-specific transcription factor, is known to drive melanoma phenotype switching from a proliferative to an invasive drug-tolerant state. Here, we found that knocking out SOX10 in human and mouse melanoma cell lines leads to the upregulation of transgluta

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Badenoch, James, Tamara Searle, Iona Watson, and Andrea E. Cavanna. "Tics in patients with encephalitis." Neurological Sciences 42, no. 4 (2021): 1311–23. http://dx.doi.org/10.1007/s10072-021-05065-w.

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Abstract Background Movement disorders have been described in the context of different types of encephalitis. Among hyperkinetic manifestations, tics have sporadically been reported in cases of encephalitis resulting from a range of aetiologies. Objective This review aimed to assess the prevalence and characteristics of tics in patients with encephalitis. Methods We conducted a systematic literature review of original studies on the major scientific databases, according to the standards outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Resu

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