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Dissertations / Theses on the topic 'Immune disorders'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Wu, Gang. "Glycomic and glycoproteomic studies of immune disorders." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/42776.

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Sugar oligomers which are linked to proteins and lipids play important roles in a large number of biological processes. These sugars are referred to as glycans. In the immune system, almost all key proteins are glycosylated. Glycans regulate the migration, recognition, activation, and apoptosis of immune cells, as well as the activities of antibodies. Owing to glycan complexity, the study of glycosylation is challenging. Mass spectrometry (MS) is a state-of-the-art technology which is ideally suited to investigating glycosylation, because of its ultra-high sensitivity and resolution, as well a

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2

Thapa, Navin. "Immune parameters in mycobacterioses, other immune disorders and the effects of immunotherapy." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313617.

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3

Hübner, M. "The utility of immune cells for studying psychiatric disorders." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603911.

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This work will present and discuss the utility of immune cells as a cellular model for studying psychiatric disorders. Novel strategic approaches in the field of psychiatry combining non-hypothesis driven global protein profiling with targeted functional analysis were applied in order to identify and classify dysregulated cellular biological process associated with a given disease. This was achieved by using a combination of modern technologies such as mass spectrometry, flow cytometry or multiple enzyme-linked immunosorbent systems. Peripheral blood monoclonal cells, cell supernatants and ser

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4

Sewell, William Arthur Carrock. "Intracellular cytokines and their therapeutic modulation in immunological disorders." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325461.

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5

Stiles, Kal. "A comparison of Topical Tacrolimus and Pimecrolimus in the Treatment of Canine Ophthalmic Auto-Immune Disorder." The University of Arizona, 2006. http://hdl.handle.net/10150/624468.

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Class of 2006 Abstract<br>Objectives: To evaluate the comparative efficacies of Tacrolimus and Pimecrolimus for the treatment of Keratoconjunctivitis Sicca (KCS), Pannus, and other autoimmune related ophthalmological disorders. Methods: A descriptive retrospective study of clinical data obtained through two separate veterinary studies. The improvement in Schirmer Tear Test (STT) between the Tacrolimus group and Pimecrolimus group is compared. Results: There were 27 canines in the Tacrolimus group, with a total of 50 affected eyes. The Pimecrolimus group had 14 total canines, but tear producti

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6

ARIA, FRANCESCA. "Role of Maternal Immune Activation in Neurodevelopmental Disorders and Possible Pharmacological Treatment." Doctoral thesis, Università degli studi di Brescia, 2021. http://hdl.handle.net/11379/544159.

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Role of Maternal Immune Activation in Neurodevelopmental Disorders and Possible Pharmacological Treatment<br>Role of Maternal Immune Activation in Neurodevelopmental Disorders and Possible Pharmacological Treatment

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7

Richetto, J. "LATE PRENATAL INFECTION AND NEURODEVELOPMENTAL DISORDERS: CHARACTERIZATION OF AN IMMUNE-MEDIATED MOUSE MODEL." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/244209.

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Compelling evidence suggests that the aetiology of multifactorial and multisymptomatic psychiatric diseases include exposures to adverse events during prenatal and early postnatal life, which may disrupt the correct maturation of neural system and lead to long-lasting changes in brain function. Prenatal insults, and in particular prenatal infection, could thus act as a “primer” for the neuropsychiatric route, even if the specificity of the illness that develops is strongly influenced by the genetic and environmental context in which the process occurs (Meyer, 2013b). A similar concept of “earl

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8

Le, Nhung Xuan Hong. "ASSOCIATION OF IMMUNE DYSFUNCTION WITH MICROBIAL DYNAMICS AND ABERRANT ESTROGEN METABOLISM IN REPRODUCTIVE DISORDERS." OpenSIUC, 2021. https://opensiuc.lib.siu.edu/dissertations/1918.

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Chronic inflammation is associated with the pathophysiology of obstetrical disorders (e.g. preterm birth [PTB]) and gynecological diseases (e.g. endometriosis); however, the exact mechanism(s) for these conditions are unknown. Numerous immunological conditions and disease states (e.g. inflammatory bowel disease, Crohn’s disease, systemic lupus erythematomus) also disrupt the microbiome homeostasis by inducing a number of changes in the microbial flora when compared to that of healthy individuals. Furthermore, the gastrointestinal (GI) microbiome is one of the principal regulators of circulatin

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9

Crossley, Alison Rachel. "Immunological parameters in immune thrombocytopenic purpura and the effects of alpha interferon therapy." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308323.

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10

Maddison, Paul. "A quantitative study of the immune-mediated neuromuscular disorders of acquired neuromyotonia and Lambert-Eaton myasthenic syndrome." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285378.

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11

Kong, Wai-kwan Wendy, and 江慧君. "The effects of immune activation in the pathogenesis of neurodevelopmental disorders : in vivo and in vitro animal studies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/197539.

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Schizophrenia and autism are psychiatric disorders with a presumed neurodevelopmental origin, characterised by clinical features and aetiologies that overlap at multiple levels. In addition to genetic susceptibility, epidemiological studies revealed an association between environmental factors and these disorders. Immune activation in response to infection at early gestation has been identified as one of the key risk factors. Little is known about the underlying mechanism during maternal immune activation (MIA), but extrinsic apoptotic dysregulation has been postulated to play a role in MIA in

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12

Davenport, Emma Elisabeth. "Functional genomics of variation in response to infection : insights into severe sepsis and common variable immune deficiency disorders." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:528edf20-f948-4a9c-aa23-1e295b11c8cc.

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Functional genomics uses high throughput genome-wide technologies to investigate the functional consequences of genetic variants on gene expression and protein products. In the context of disease, using integrative functional genomic approaches to understand the genetic variation which underlies disease susceptibility and aetiology may contribute to better diagnosis, treatment and prevention. This thesis investigated genetic determinants of variation in response to infection by applying a functional genomics approach to investigate three clinical cohorts: patients with severe sepsis, an influe

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13

Saif, Muhammad A. "Immune responses in patients with lysosomal storage disorders treated with enzyme replacement therapy and haemopoietic stem cell transplantation." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/immune-responses-in-patients-withlysosomal-storage-disorders-treated-with-enzyme-replacement-therapy-and-haemopoietic-stem-cell-transplantation(e745df5b-44d5-4803-bbe1-db31ad9e6f75).html.

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Lysosomal storage disorders (LSDs) are caused by defective lysosomal degradation of macromolecules resulting in accumulation of substrates in various tissues. This gradually leads to organ dysfunction and the classical clinical presentation with multisystem involvement. Historically the management of LSDs was confined to symptomatic treatment only. More recently other therapies have become available. Treatment options include cellular therapy in the form of Haemopoietic Stem Cell Transplant (HSCT), Enzyme Replacement Therapy (ERT), Substrate Reduction Therapy (SRT), Chaperone Mediated Therapy

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14

Msebele, Bongiwe. "Application of Sutherlandia flutescens in cosmetic skin industry (phytochemical fingerprinting and its activity against skin immune diseases." University of the Western Cape, 2019. http://hdl.handle.net/11394/7368.

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>Magister Scientiae - MSc<br>Hyperpigmentation disorders such as melasma, freckles and black-pigmented spots on the surface of the skin are often a result of increased over production and accumulation of melanin pigments in the skin. In melanin biogenesis, tyrosinase is the key enzyme that catalysis the synthesis of melanin, thus the most effective and easiest way to reduce melanin synthesis is by inhibiting tyrosinase. There are a large number of reported tyrosinase inhibitors, their identification and isolation from natural sources is highly important because when natural tyrosinase in

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15

GIORGI, MARIANI MICHELA. "MECHANISM OF ACTION OF ELECTROCONVULSIVE THERAPY (ECT): A NEUROIMMUNOCHEMICAL APPROACH." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1071492.

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Background: Electroconvulsive therapy (ECT) is one of the most effective and fast acting therapeutic options for treatment-resistant psychiatric diseases, in particular mood disorders. Mood disorders are highly heterogeneous, disabling and severe mental illness, at still unknown etiology, which have been associated with a multifaceted pathogenesis, encompassing genetic, epigenetic and metabolic vulnerabilities together psychosocial/lifestyle factors. Among the various biological patterns thought to be involved in the physiopathology of dysthymia, major depression, cyclothymia, bipolar I, II,

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16

Parker-Athill, Ellisa Carla. "Maternal Immune Dysregulation in the Pathogenesis of Neurodevelopmental Disorders: Interleukin-6 as a Central Mechanism and Therapeutic Target of Flavonoids." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4195.

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Activation of the maternal immune system and resultant maternal cytokine expression due to prenatal infection has been implicated as a significant contributor to the pathology of neuropsychiatric and neurodevelopmental disorders such as schizophrenia and Autism Spectrum Disorder (ASD). Increased maternal interleukin-6 (IL-6) expression, observed clinically and in animal models of prenatal infection, and resultant activation of key signaling pathways, has been shown to be a biological indicator of pathology, and a central component of the pathological mechanism. In animal models of prenatal i

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17

Mathsson, Linda. "Immune Complex Regulated Cytokine Production in Rheumatic and Lymphoproliferative Diseases." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7446.

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18

Nkambule, Bongani Brian. "Platelet flow cytometry and coagulation tests as markers of immune activation in chronic HIV infection." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20373.

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Thesis (MScMedSc)--Stellenbosch University, 2012.<br>Bibliography<br>ENGLISH ABSTRACT: Background: In the era of antiretroviral therapy (ART), the risk of acquired immune deficiency syndrome (AIDS) related deaths has decreased and people living with Human Immunodeficiency Virus (HIV) now have prolonged life spans. However, an increasing trend of non-AIDS associated deaths has been reported despite adequate control of viral loads. HIV infection is established as a chronic inflammatory condition which is associated with an increased risk for thrombosis. Thus HIV infected patients are at a h

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19

Steimle, Alexander [Verfasser], and Julia-Stefanie [Akademischer Betreuer] Frick. "How intestinal commensals affect the immune system and the outcome of inflammatory disorders : novel molecular insights / Alexander Steimle ; Betreuer: Julia-Stefanie Frick." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1199545643/34.

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20

Gleadhill, Claire, and Demetrio Jr Macariola. "Time to Think Deeper when HSV is Presenting in an Unusual Way." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/153.

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This study demonstrates the first case report in which an NK Cell deficiency initially presented as an asymptomatic disseminated herpes simplex viremia (HSV). A pre-term 13- day- old patient presented with disseminated HSV after investigation because his twin brother was found to have HSV vesicular lesions. The patient remained asymptomatic throughout the entire hospital course. While 40% of neonates never exhibit vesicular lesions, most of the infants will be symptomatic with DIC and/or respiratory and/or hepatic failure. The HSV development in his twin brother prompted immediate multiple HSV

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21

Sharma, Purva, Bahaaeldin Youssef, Sakshi Singal, and Devapiran Jaishankar. "In Situ Follicular Neoplasia yet another Spectrum That Extends From Normalcy to Overt Malignancy." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/28.

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In situ follicular neoplasia (ISFN) is defined as a monoclonal proliferation of B cells with immunophenotypic and genetic features of follicular lymphoma (FL) but confined to germinal centers of lymph nodes or other organs. It may not be associated with underlying overt lymphoma. It can be associated with lymphoproliferative disorders other than FL. A fifty-seven-year-old caucasian male initially presented with atypical chest pain, which led to cardiology evaluation. Patient underwent a coronary CT angiogram, which revealed a calcium score of 0, however also incidentally revealed mediastinal l

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22

Parira, Tiyash. "Epigenetic Mechanisms Regulating the Functional Effects of Chronic Alcohol Exposure of Human Monocyte-derived Dendritic Cells." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3890.

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The effects of alcohol abuse are multi-dimensional since alcohol is widely known to affect both the innate and adaptive immune systems. Recently, epigenetics has come into focus and has been implicated in many diseases as well as substance abuse disorders. Therefore, research efforts of understanding the epigenetic mechanisms underlying substance abuse effects including alcohol abuse have become more predominant. In our laboratory, we have studied different epigenetic changes induced by alcohol exposure including regulation of histone deacetylases (HDACs), histone quantity, and histone modific

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23

Rehman, Haroon, Asha Chepkorir Segie, Kanishka Chakraborty, and Devapiran Jaishankar. "Bone Marrow Wars: Attack of the Clones." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/33.

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Multiple myeloma is characterized by the malignant proliferation of clonal plasma cells producing monoclonal paraproteins, leading to multi-organ damage. On the other hand monoclonal B-cell lymphocytosis (MBCL) is characterized by the malignant proliferation of clonal B-lymphocytes, with potential to develop into chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). CLL/SLL can result in visceromegaly, anemia, thrombocytopenia, fevers, night sweats and unintentional weight loss. Literature review demonstrates these two malignant clonal bone marrow disorders are most frequentl

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24

PERINI, MATTEO. "INVESTIGATION ON THE ROLE OF NUTRITION AND BACTERIA IN HUMAN HEALTH USING NEXT GENERATION SEQUENCING (NGS): FROM GUT MICROBIOTA IN IMMUNE-RELATED DISORDERS TO GENOMIC EPIDEMIOLOGY." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/918427.

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La nutrizione e il sistema immunitario hanno un ruolo fondamentale nel plasmare la comunità microbica intestinale; da parte sua, la variazione nella composizione del microbiota può influenzare notevolmente lo stato di salute. Alcuni ceppi batterici sono generalmente associati ad effetti benefici (ad esempio i Lattobacilli ed i Bifidobatteri nell'intestino umano), mentre altri membri del microbiota possono causare alterazioni patologiche ed infezioni sistemiche. Durante il mio periodo di dottorato, ho utilizzato le tecnologie Next Generation Sequencing (NGS) per indagare queste relazioni batter

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MEZZETTI, MATTEO. "Nuove indagini sul metabolismo e la risposta immunitaria dalla messa in asciutta all'avvio di lattazione." Doctoral thesis, Università Cattolica del Sacro Cuore, 2019. http://hdl.handle.net/10280/59476.

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Il sistema immunitario è costituito da una varietà di cellule, molecole e processi biologici che interagiscono per prevenire le invasioni microbiche, riconoscere le molecole estranee ed eliminare le fonti esistenti di lesioni cellulari, ripristinando le normali funzioni tissutali una volta risolto il problema. L'immunità innata è la prima linea di difesa contro le invasioni di agenti patogeni. Nelle vacche da latte, il suo funzionamento subisce gravi alterazioni durante il periodo di transizione (TP). In questa fase è stata segnalata una compromissione delle funzioni delle cellule polimorfonuc

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MEZZETTI, MATTEO. "Nuove indagini sul metabolismo e la risposta immunitaria dalla messa in asciutta all'avvio di lattazione." Doctoral thesis, Università Cattolica del Sacro Cuore, 2019. http://hdl.handle.net/10280/59476.

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Il sistema immunitario è costituito da una varietà di cellule, molecole e processi biologici che interagiscono per prevenire le invasioni microbiche, riconoscere le molecole estranee ed eliminare le fonti esistenti di lesioni cellulari, ripristinando le normali funzioni tissutali una volta risolto il problema. L'immunità innata è la prima linea di difesa contro le invasioni di agenti patogeni. Nelle vacche da latte, il suo funzionamento subisce gravi alterazioni durante il periodo di transizione (TP). In questa fase è stata segnalata una compromissione delle funzioni delle cellule polimorfonuc

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27

Allard, Marie-Julie. "Rôle de l’activation immune maternelle par le Streptocoque de groupe B dans la physiopathologie de l’autisme." Mémoire, Université de Sherbrooke, 2015. http://hdl.handle.net/11143/6973.

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Résumé : Le streptocoque de groupe B (SGB) est une bactérie commensale présente dans le tractus génito-urinaire de 10 à 30 % des femmes enceintes en santé. Ce pathogène est responsable de chorioamnionite, associée aux naissances prématurées et aux dommages cérébraux du nouveau-né. Les infections durant la grossesse, la chorioamnionite et la prématurité sont associées au développement de troubles du spectre de l’autisme. Notre hypothèse est qu’une exposition subclinique au SGB induit une réponse inflammatoire maternofoetale, menant à des troubles neurodéveloppementaux et comportementaux de type

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28

Faustino, Lucas da Silva. "Células T reguladoras na asma experimental." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-11012011-150838/.

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Células T reguladoras (Treg) são cruciais na tolerância periférica e no controle da inflamação. Nós usamos dois modelos bem estabelecidos de tolerância de mucosas para a asma alérgica e a tolerância inalatória local induzida pela exposição crônica a OVA para estudar o aparecimento e função das Treg. Nós mostramos que a tolerância nasal distinguiu da tolerância oral pela produção sistêmica de IgG1 e desenvolvimento da inflamação alérgica na cavidade peritoneal ou pela indução da inflamação das vias aéreas de camundongos RAG-/- reconstituídos com células T CD4+ após desafios com OVA. Observamos

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Paiva, Aldair de Sousa. "Avalia??o dos par?metros hematol?gicos e imunofenot?picos de pacientes com doen?as linfoproliferativas cr?nicas no Rio Grande do Norte." Universidade Federal do Rio Grande do Norte, 2014. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13415.

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Made available in DSpace on 2014-12-17T14:14:03Z (GMT). No. of bitstreams: 1 AldairSP_DISSERT.pdf: 3401140 bytes, checksum: 29fad07626595e61c30bdf3a90539133 (MD5) Previous issue date: 2014-02-26<br>Chronic lymphoproliferative disorders (DLPC) are lymphoid system diseases characterized by the abnormal proliferation of mature lymphocytes that affect B cells, T lymphocytes and NK cells. The aim of the study was to demonstrate the relevance of immunophenotyping by flow cytometry in patients with prolonged lymphocytosis and / or cytomorphological c

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Lima, Flavia Afonso. "Estudo da expressão da proteína AIRE (autoimmune regulator) e dos componentes da via de sinalização Notch em timos humanos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-04082011-150437/.

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O timo é o órgão linfóide primário responsável pelo estabelecimento inicial de um repertório funcional de células T. A via de sinalização Notch é essencial para o desenvolvimento de células T a partir de células-tronco hematopoiéticas, e a distribuição de seus receptores e ligantes no timo humano ainda é desconhecida. A expressão de AIRE é crucial para a seleção de um repertório de receptores de linfócitos T (TCR) sem autorreatividade. Neste estudo, analisamos o padrão de expressão de AIRE e a distribuição de Notch em timos pacientes com cardiopatias congênitas, parte dos quais com síndrome de

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Leo, Melanie Joy. "Sequence-based molecular diagnosis of X-linked agammaglobulinemia in South African individuals." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6476.

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Thesis (MScMedSc)--University of Stellenbosch, 2011.<br>ENGLISH SUMMARY: Background: Primary immunodeficiency disorders (PID) disrupt the proper functioning of the immune system. The prototypic PID is X-linked Agammaglobulinemia (XLA). This disorder is caused by mutations in the Bruton tyrosine kinase (Btk) gene and results in an arrest in B cell development which leads to a profound reduction of all classes of serum immunoglobulins (i.e antibodies). Patients with a lack of antibodies experience recurring bacterial infections during early childhood that can be fatal if not treated. Intrav

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Malaisé, Yann. "Caractérisation chez la souris adulte des impacts immuno-modulateurs des bisphénols après exposition périnatale : conséquences sur la fonction "barrière" de l'intestin et la susceptibilité aux désordres métaboliques." Thesis, Toulouse, INPT, 2017. http://www.theses.fr/2017INPT0119/document.

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Le bisphénol A (BPA) est un perturbateur endocrinien couramment employé dans l’industrie agroalimentaire, en particulier pour les matériaux en contact des denrées alimentaires. Son utilisation dans la fabrication de polycarbonates et de résines époxy, recouvrant la face interne des boîtes de conserve et des canettes, en fait un contaminant ubiquitaire de l’alimentation humaine. L’augmentation de l’exposition humaine à ce contaminant a été corrélée avec la récurrence de certains troubles comme l’intolérance alimentaire, l’obésité ou le diabète de type 2. Ces dernières années, une attention part

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Mabrouk, Maha. "Évaluation de l’effet correcteur d’un extrait polyphénolique de pépins de raisin dans un modèle murin de sclérose en plaques, l’encéphalomyélite auto-immune expérimentale." Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2022. http://www.theses.fr/2022UCFAC111.

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La sclérose en plaques (SEP) est une maladie auto-immune du système nerveux central générant de nombreux symptômes neurologiques, parmi lesquels la douleur chronique qui est très invalidante et fréquente. A ce jour, la SEP est une maladie incurable avec une étiologie complexe, multifactorielle et encore mal comprise. De nombreuses données suggèrent que les polyphénols végétaux pourraient avoir des bénéfices thérapeutiques en régulant le stress oxydant et la neuroprotection dans la SEP. Dans ce contexte, ce travail de thèse a pour objectif d’évaluer l'effet d’un traitement curatif chronique à l

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Oliveira, José. "Diversité Génétique des Molécules de Réponse Immunitaire Innée dans les Troubles Bipolaires." Thesis, Paris Est, 2015. http://www.theses.fr/2015PESC0043.

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Les troubles bipolaires (TB) sont des troubles chroniques, multifactoriels et multi-systémiques avec une morbidité, mortalité et fardeau socio-économique très élevée. Mieux comprendre le fond génétique et les facteurs environnementaux déclencheurs permettra d'améliorer le diagnostic et la prise en charge thérapeutique. La dysimmunité semble être parallèle à l'apparition, la progression ainsi qu'au développement de comorbidités psychiatriques et somatiques. L'inflammation chronique et l'activation de la microglie sont des mécanismes liant potentiellement l'infection et le stress pendant l'enfan

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Jeans, Aruna. "The peripheral immune system of glycosphingolipid storage disorder mouse models." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432342.

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Gonçalves, Andréia de Souza. "Avaliação de moléculas envolvidas no escape imunológico em desordens potencialmente malignas de boca." Universidade Federal de Goiás, 2017. http://repositorio.bc.ufg.br/tede/handle/tede/6953.

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Shelton, Heath W., and Russell W. Brown. "INHIBITION OF TNF-ALPHA DECREASES MICROGLIA ACTIVATION IN RATS NEONATALLY TREATED WITH POLY I:C." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/166.

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Introduction: Current medical treatment for individuals diagnosed with schizophrenia (SCHZ) primarily relies on the inhibition of the dopamine D2 receptor that has been shown to be supersensitive in these patients. Treatment occurs through the use of antipsychotic medication which leads to a number of debilitating dose-dependent side effects, such as weight gain, agranulocytosis, and seizures. Patients diagnosed with SCHZ have also been shown to have increased inflammation in their central nervous system (CNS), particularly within specific brain regions such as the prefrontal cortex and hippoc

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Ross, Colin J. D. "Immuno-isolation gene therapy for lysosomal storage disease /." *McMaster only, 2001.

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39

Goyal, Daniel Kumar. "Environmental factors associated with autism spectrum disorder : a clinical study of microflora and micronutrient abnormalities." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/environmental-factors-associated-with-autism-spectrum-disorder-a-clinical-study-of-microflora-and-micronutrient-abnormalities(ee9e4c21-9c3e-48cc-9c80-8b8ee38ca8b9).html.

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Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised by impaired socialisation. The current project examines the hypothesis that ASD represents a broad range of distinct disease processes typified by environmental insult(s) during a period crucial for the development of any of the systems responsible for social integration skills, sharing simply the fundamental disruption to social functioning with various, definable systemic pathologies related to the initial insult conferring the heterogeneity of the condition. ASD will therefore have both modifiable environmental fa

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Mullen-Houser, Elizabeth Ann. "Immune-spectrum disease among female veterans: relations with posttraumatic stress disorder and maladaptive repetitive thought." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/2589.

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BACKGROUND: Female veterans are at risk for stress-related physical disorders given unique environmental stress factors, high rates of trauma exposure and a heightened physiologic stress response. There is a need to identify modifiable risk factors which may help minimize the emergence and impact of veteran illness. RESEARCH QUESTION: The present study investigated the contributions of posttraumatic stress symptoms, maladaptive repetitive thought (MRT), depression, childhood trauma and health behaviors (sleep, alcohol use

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Jones, Hannah. "Maternal Autoimmunity and Inflammation are associated with Childhood Tics and Obsessive-Compulsive Disorder." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/26281.

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Although genetic variation is a major risk factor of neurodevelopmental disorders (NDDs) such as tics and childhood obsessive-compulsive disorder (OCD), environmental factors during pregnancy and early life are important in disease expression. Epidemiological studies and animal models indicate maternal inflammation is one potential environmental factor. In my thesis, I compared the frequency of proinflammatory states in mothers of 200 children with tics/OCD with 100 autoimmune neurological controls and 100 age- and sex-matched healthy controls. I prospectively recruited children with tics/OCD

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Borianne, Tom. "Immune synapse : T cell receptor clustering is associated with a liquid-disordered plasma membrane." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0459.

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La composition lipidique et protéique de la membrane des lymphocytes T est remodelée pendant la formation de la synapse immunologique. Le fait que ce remodelage puisse être accompagné d’un changement d’ordre n’a pas été élucidé. En combinant imagerie solvatometriques et quantitative en live, nous avons observé que l’interaction agoniste TCR-pMHC induit une séparation de phase du feuillet externe de la membrane plasmique de lymphocytes T murins, au contact d’une cellule présentatrice d’antigène. Etonnamment, le TCR partitionne dans la région liquide désordonnée de la membrane plasmique et ce ph

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Hamer, Rebecca K. "The structural basis of immune receptor signalling." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:32312040-2e22-4fe3-b05e-6f868233e27e.

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This work investigates the mechanisms of binding of T cell receptors (TCRs) to Class I MHC-peptide complexes (pMHC). The structure of a TCR specific for the Melan-A tumour antigen bound to its cognate pMHC was solved to a resolution of 2.5 Å which gives insight into how this TCR could be mutated to optimize binding and subsequently used as a cancer vaccine. Detailed sequence and geometric analyses of all currently available structures of Class I TCR-pMHC complexes revealed that TCRs can bind to pMHC with a range of orientations, yet always focus on the central portion of the peptide and use a

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Tiwari, Swati. "Gene Therapy Approaches for Hemophagocytic Lymphohistiocytosis." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1447690858.

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Tursich, Mischa. "Relationships between Psychological Distress and Immune Function in Women with a History of Childhood Maltreatment." Thesis, NSUWorks, 2012. https://nsuworks.nova.edu/cps_stuetd/72.

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Exposure to traumatic events can lead to many varied psychological and physiological difficulties, including an increased risk for chronic physical health problems and chronic pain disorders, which are thought to be mediated through the three major biological systems involved in the human stress response. The objective of the present study was to examine the relationships between psychological symptoms and proinflammatory immune markers, Interleukin-1β (IL-1β) and Interleukin-6 (IL-6), which are thought to be related to many of the physical health problems associated with posttraumatic psychop

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Cheung, Michael Brian. "Immune System mModulation in Victims of Intimate Partner Violence." University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1258134841.

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Lynn, Courtney A. "Health Literacy, Depression, Anxiety, and Posttraumatic Stress Disorder as Predictors of Biological Markers of Immune Functioning in Youth and Young Adults with HIV." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/6891.

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Human immunodeficiency virus (HIV) is a virus that affects the body’s immune system (Centers for Disease Control [CDC], 2016a). HIV is a worldwide epidemic and disproportionately impacts youth in the United States. Youth living with HIV (YLWH) face significant mental health problems, namely depression, anxiety, and posttraumatic stress disorder (PTSD) with rates of these disorders discrepant from those in the general population. In addition to psychological difficulties, health literacy is another factor that influences individuals with HIV and is a priority of research with adolescents (Kalic

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Johansson, Martin. "Systemic lupus erythematosus and rheumatoid arthritis analyses of candidate genes involved in immune functions, for susceptibility and severity /." Doctoral thesis, Umeå : Umeå university, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-30388.

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Mexal, Sharon. "Differential expression in the hippocampus of schizophrenic and control smokers : a high-throughput analysis of the effects of psychopathology, smoking, and postmortem brain parameters on gene expression /." Connect to full text via ProQuest. IP filtered, 2005.

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50

Winter, Sarah. "Identification and characterization of new genetic defects involved in Epstein-Barr virus immune response and T-cell proliferation Loss of RASGRP1 in humans impairs T-cell expansion leading to Epstein-Barr virus susceptibility RASGRP1 is a negative factor of EOMES expression in T cells in association with an exhausted phenotype IL-27RA deficiency in humans, a new cause of susceptibility to Epstein-Barr virus infection Association of bi-allelic loss-of-function mutations in PIK3CD and TNFRSF9 causes fatal chronic active Epstein-Barr virus infection with T-cell lymphoproliferation." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB180.

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L'infection par le virus d'Epstein-Barr (EBV) touche plus de 90% de la population mondiale et est dans la majorité des cas asymptomatique dans l'enfance. Certains individus, souvent à l'adolescence, développent une primo-infection symptomatique appelée mononucléose infectieuse. L'EBV peut également entraîner chez des individus immunodéprimés des désordres lymphoprolifératifs, des lymphomes ou syndromes d'activation lymphohistiocytaire. Depuis une trentaine d'années plusieurs déficits immunitaires primitifs entraînant une susceptibilité particulière à l'infection par l'EBV ont été identifiés ;

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