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Dissertations / Theses on the topic 'Immune health'

Author: Grafiati

Published: 10 January 2023

Last updated: 31 July 2025

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1

Shbat, Layla. "Immune modulation in cardiovascular disease." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103617.

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The importance of the adaptive immune response in cardiovascular disease has been increasingly appreciated. However, limited information is available on immune modulation in the context of hypertension and atherosclerosis. In order to fill this knowledge gap, the amount of T regulatory (Treg) cells was determined by flow cytometry on cells from the spleen and the aorta in two murine models, namely angiotensin (Ang) II-induced hypertension (HT) and endothelin-1 (ET-1)-exacerbated high fat diet (HFD)-induced atherosclerosis in apolipoprotein E knockout (apoE-/-). Two groups of mice were studied.

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2

Liu, Yuhong. "Sigma Receptors and the Immune System /." The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487930304687004.

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3

Esplin, Brandt L. "Replenishment of innate immune system in health and disease." Oklahoma City : [s.n.], 2009.

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4

Cho, Sungyoo. "Immune evasion of CD1d molecules and NKT cells in the innate immune response against viruses." [Bloomington, Ind.] : Indiana University, 2005. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3185405.

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Thesis (Ph.D.)--Indiana University, 2005.<br>Source: Dissertation Abstracts International, Volume: 66-08, Section: B, page: 4071. Chair: Randy R. Brutkiewicz. Title from dissertation home page (viewed Oct. 10, 2006).

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5

Hassan-Zahraee, Mina. "Anergy and the human skin immune system." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=42051.

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An initial study comparing cytokine gene expression in the skin of control vs. anergic patients lacking delayed type hypersensitivity reactivity revealed no difference; but disclosed an apparent absence of detectable CD3+ T cells in the skin of anergic individuals. To assess its significance for anergy, an investigation of the role of skin T cells in DTH-reactive healthy individuals was undertaken. To do so, the phenotypic and functional characteristics of T cells isolated from skin and blood were compared. Analysis by flow cytometry has shown that 74% of skin T cells expressed cell surface HL

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6

Singh, Rekha. "Cellular immune responses in HSV and CMV infections." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/29036.

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The herpes simplex virus (HSV) and cytomegalovirus (CMV) are the prominent members of the Herpesviridae family collectively responsible for the majority of herpes-related morbidity and mortality in humans. These viruses are therefore the subjects of this study that was undertaken to improve our understanding of the nature of immune response and the mechanism of viral modulation leading to suppression of viral replication or evasion of the host immune response in vivo. The present study has examined the T helper responses to HSV-2 and murine CMV (MCMV) and provides new insights into the nature

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7

Shey, Muki Shehu. "Determinants of innate immune responses to mycobacteria." Doctoral thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/10986.

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Includes bibliographical references.<br>Innate cells such as macrophages, monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers. The type and magnitude of innate responses to mycobacteria may determine the subsequent adaptive responses generated. Our aims were to determine maturational changes in innate immune responses to mycobacteria over the first 9 months of life, and to assess effects of genetic variations in toll-like receptors on host responses to mycobacteri

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8

Wechsler, Daniel Steven Gary. "Immune mechanisms of cure in Trypanosoma musculi infection." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75348.

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Trypanosoma musculi is a protozoan parasite which produces a characteristic, self-limiting murine infection of approximately three weeks duration; the infection comprises a growth phase, a plateau phase and an elimination phase. Following clearance of parasitaemia, a mouse is cured and immune to reinfection. The present studies examine the immune mechanisms which operate during the elimination phase.<br>Passive transfer of plasma from an immune mouse to an infected recipient brings about rapid and complete clearance of parasitaemia in C57BL/6 mice. This curative activity is labile to heat trea

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9

Aziz, Douglas C. "Molecular studies on murine acquired immune deficiency syndrome (MAIDS)." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74558.

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The Duplan strain of Radiation Leukemia Virus (RadLV) induces an AIDS-like syndrome when injected intraperitoneally into adult C57BL/6 mice. The mice develop T cell depletion, polyclonal B cell proliferation (lymphadenopathy, splenomegaly), hypergammaglobulinemia, and immune deficiency. This syndrome has recently been designated MAIDS (murine acquired immunodeficiency syndrome). This virus preparation, passaged in vivo, is crude and known to contain different strains of retroviruses. To identify the etiologic agent of this disease, we first infected fibroblasts in vitro with this crude virus m

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10

Tran, Elise H. "Immune invasion and glial activation in experimental autoimmune encephalomyelitis." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36845.

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Leukocyte recruitment into tissues in response to infection or injury is a crucial event for the elimination of pathogens to protect the host. However, when leukocytes invade the central nervous system (CNS) and neuromflammatory disorders result, neurological function may be compromised. Infiltration of the CNS, predominantly by T cells and macrophages, characterizes Multiple Sclerosis and its animal counterpart, Experimental Autoimmune Encephalomyelitis (EAE).<br>Autoreactive T cells that initiate EAE produce Th1 cytokines (e.g., IFNgamma, TNFalpha). Nevertheless, previous studies also indica

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11

Vizel, Mark. "The effect of blood transfusion upon the immune system /." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61951.

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12

Gill, Margaret Elizabeth. "Estuarine fish and their health, as indicators of anthropogenic change." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388651.

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13

Sánchez-Hurtado, Karla. "Pathogenesis of Clostridium difficile and immune response in health and disease." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/25149.

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Most patients colonized with <i>C. difficile</i> remain asymptomatic. When <i>C. difficile</i>-associated disease (CDAD) presents, it ranges from mild diarrhoea to severe diarrhoea that can lead to severe complications which can result in colectomy or even death. It is not clear why some patients remain asymptomatic while others present severe disease but one hypothesis is that patients who develop symptoms have lower levels of specific antibodies to <i>C. difficile</i> than those who remain asymptomatic after colonization with <i>C. difficile.</i> The levels of systemic antibodies were analys

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14

Xiao, Wenchang. "Structural Health Monitoring and Fault Diagnosis based on Artificial Immune System." Digital WPI, 2012. https://digitalcommons.wpi.edu/etd-theses/169.

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This thesis presents a development of Structural Health Monitoring (SHM) and Fault Diagnosis based on Artificial Immune System (AIS), a biology-inspired method motivated from the Biological Immune System (BIS). Using the antigen to model structural health or damage condition of specific characteristics and the antibody to represent an information system or a database that can identify the specific damage pattern, the AIS can detect structural damage and then take action to ensure the structural integrity. In this study the antibodies for SHM were first trained and then tested. The feature spac

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15

Rowsell, Paul. "Oral tolerance and immune mechanisms in food-induced diabetes." Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/9599.

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Diet controls $\sim$80% of type-I (insulin-dependent) diabetes in the diabetes-prone BioBreeding (BBdp) rat. This study was designed to define the relationship among diet, the gut immune system and the pancreas. BB rats were fed either a diabetogenic NIH-07 (NIH) diet or the diabetes protective, hydrolysed casein (HC) diet. Bovine serum albumin (BSA), ovalbumin (OVA), sheep red blood cells (SRBC) and NIH were given by gavage daily for 5 days. Both BBdp and the diabetes resistant BBc rat when fed NIH became unresponsive in antibody production to NIH antigens. None of the other oral antigen trea

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16

Sefik, Esen. "Individual Microbes Shape Various Parts of the Immune System." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845459.

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The gastrointestinal tract, home to a vast number of bacteria, requires finely-tuned regulatory and effector immune mechanisms to maintain homeostasis and tolerance. In a large-scale screen, we studied the impacts of single microbes on major immune populations, whole intestinal tissue homeostasis and metabolism. Bacteria interacted with the host at multiple levels including cytokine responses, accumulation of various T cells, alterations in composition of mononuclear phagocytes and induction of epithelial cell genes as measured by transcriptome analysis of whole intestinal tissue. Interestingl

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Loughhead, Scott McNabb. "Immune Surveillance by Effector and Memory CD8+ T Cells." Thesis, Harvard University, 2016. http://nrs.harvard.edu/urn-3:HUL.InstRepos:26718721.

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During priming, CD8+ T cells integrate a plethora of signals that affect their differentiation into subsets of CD8+ T cells with distinct migratory properties and functions. Given that CD8+ T cells exert their protective function via cell-cell contacts, the migratory patterns and spatial distribution of CD8+ T cell subsets induced by primary challenge are of critical importance to the host. Dendritic cells (DCs), as the primary initiators of these responses, play a pivotal role in shaping the size and differentiation status of CD8+ T cells that emerge. However, inadequate markers for CD8+ T ce

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18

Aboalela, Ali Anwar. "Immune Reconstitution of B Cells Following Allogeneic Hematopoietic Cell Transplantation." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17331949.

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Objectives: Graft versus host disease (GVHD), infections and disease relapse continue to be major complications of allogeneic hematopoietic cell transplantation (HCT). B cell abnormalities have been associated with these complications, and the objective of these studies was to identify and quantify abnormalities of B cell recovery after allogeneic HCT. Methods: Flow cytometry was used to analyze peripheral blood from healthy donors (HD) and samples obtained at 1, 2, 3, 6, 9, 12, 18, 24, 30, and 36 months post HCT. A panel of 8 fluorophore-conjugated monoclonal antibodies specific for B cell su

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19

Verbeke, Catia Stephanie. "Antigen-specific immune modulation using an injectable biomaterial." Thesis, Harvard University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3627259.

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<p> The field of immunology has advanced tremendously over the last 40 years, with seminal findings that have guided the development of powerful new therapies. However, the ability to induce safe and long-lasting antigen-specific tolerance has remained elusive. A therapy that could prevent the immune system from aberrantly destroying self-tissues, without impairing its capacity to eliminate dangerous pathogens, would be transformative for the treatment of autoimmune diseases. In addition, such a therapy could also greatly advance the field of organ transplantation by inducing antigen-specific

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20

Daftarian, Mohammad Pirouz. "Adverse reactions to sulfamethoxazole in HIV seropositive patients, immune aspects." Thesis, University of Ottawa (Canada), 1993. http://hdl.handle.net/10393/6759.

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Adverse reactions to sulfonamides were initially described more than 50 years ago. It is not yet clear whether these side effects are due to immunological reactions or drug toxicity. More than 50% of AIDS patients develop adverse reactions to sulfamethoxazole, a sulfonamide drug commonly used for the treatment of infections in these individuals. In order to study the possible role of the humoral immune response in adverse reactions to SMX in HIV-seropositive patients, I designed an ELISA to determine the classes, subclasses and the quantities of the immunoglobulins directed against SMX. Twenty

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21

Contreras, Garcia Irazú. "Modulation of the host innate immune response by «Leishmania» parasites." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95096.

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Leishmania parasites have evolved sophisticated mechanisms to subvert macrophage immune responses in order to survive inside the mammalian host. Among these mechanisms are the rapid activation of phosphatases that in turn will inactivate protein kinases and transcription factors, causing abrogation of nitric oxide (NO) production and induction of immunosuppressive molecules. This doctoral thesis discusses novel mechanisms of how the parasite modulates the immune response of macrophages and dendritic cells. Herein, we describe the role of Myeloid Related Proteins (MRPs) 8 and 14 during Leishma

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22

Whitlock, Ben B. "Sigma receptors and the immune system: Identification, localization and functional significance /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487945744571017.

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23

Youniss, Fatma. "MULTI – MODALITY MOLECULAR IMAGING OF ADOPTIVE IMMUNE CELL THERAPY IN BREAST CANCER." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3323.

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Cancer treatment by adoptive immune cell therapy (AIT) is a form of immunotherapy that relies on the in vitro activation and/or expansion of immune cells. In this approach, immune cells, particularly CD8+ T lymphocytes, can potentially be harvested from a tumor-bearing patient, then activated and/or expanded in vitro in the presence of cytokines and other growth factors, and then transferred back into the same patient to induce tumor regression. AIT allows the in vitro generation and activation of T-lymphocytes away from the immunosuppressive tumor microenvironment, thereby providing optimum c

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24

Lucas, Robyn Marjorie, and robyn lucas@anu edu au. "Socioeconomic status and health: exploring biological pathways." The Australian National University. National Centre for Epidemiology and Population Health, 2004. http://thesis.anu.edu.au./public/adt-ANU20060426.095241.

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The cross-sectional Biomarkers Study was undertaken in Canberra, Australia (2000-2002) to examine the role of psychosocial factors in the socioeconomic health gradient, via physiological changes consequent upon activation of the neuroendocrine stress response.¶ The study population was derived from healthy 40-44 year old men and women already participating in a longitudinal cohort study. Using data from the cohort study, four groups with similar occupational status were formed. The study sample was randomly selected within these groups, thus representing the socioeconomic spectrum.¶ A pilot st

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25

Zhang, Jiachen. "Development of a parameter-insensitive artificial immune system for structural health monitoring." Digital WPI, 2014. https://digitalcommons.wpi.edu/etd-theses/248.

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An innovative artificial immune system (AIS) is proposed herein for structural health monitoring (SHM) to ensure the structural integrity and functionality. While satisfactory results were obtained by previous AIS schemes, their performance is strongly structural-parameter-value (SPV) dependent and deviations of SPVs in testing from training due to modeling errors and measurement noises significantly deteriorates the AIS' performance. This thesis presents a less SPV-dependent AIS with a three-phase architecture, including damage-existence-detection, damage-location-determination, and damage-se

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26

Payne, Caleigh. "The role of prebiotics in dairy calf performance, health, and immune function." Thesis, Kansas State University, 2015. http://hdl.handle.net/2097/20420.

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Master of Science<br>Animal Sciences and Industry<br>Lindsey E. Hulbert<br>Rapid responses in milk production to changes in dairy cow management, nutrition, and health give producers feedback to help optimize the production and health of dairy cattle. On the contrary, a producer waits up to two years before the investments in calf growth and health are observed thru lactation. Even so, performance, health, and immune status during this time play a large role in subsequent cow production and performance. A recent report from the USDA’s National Animal Health Monitoring System estimated that

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Shank, Alba Maria Montana. "Effects of Stress on Several Immune and Health Responses of Weanling Calves." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/34898.

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The effects of weaning stressors on several immune and health responses were measured in three experiments. Sixty-four beef calves from 2 sources were bled on d - 7 (pre-weaning), 0 (weaning), 7, 14, and 21 (post-weaning). Serum selenium (Se), neutrophil and lymphocyte counts, and glutathione peroxidase (GSH-Px) activity for erythrocytes and leukocytes were measured for each calf at each date. Erythrocyte GSH-Px activity remained constant over time, while leukocyte GSH-Px and serum Se increased on d 7 (P<0.0001). Effects of single mineral vs. multi-mineral supplementation were measured for

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28

Colbey, Candice M. "Transcriptional and translational networks linking the immune system to health and disease." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/390022.

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The contents of this thesis are organised into seven chapters and one appendix. Chapter 1 includes two literature reviews that discuss important factors associated with the development of upper respiratory symptoms (URS) in elite athletes. The first review discusses URS, its incidence and prevalence in elite athletes as well as the effects that exercise has on the immune system at the level of immune gene expression, immune cell phenotype and immunometabolism. The second review was published in Sports Medicine and is presented here in its published form. This review discusses the relationship

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29

Malik, Suneil. "Genetics of host innate immune factors in Tuberculosis susceptibility." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85578.

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Tuberculosis, caused by Mycobacterium tuberculosis, is globally a leading cause of morbidity and mortality. While a host genetic contribution to tuberculosis susceptibility is known to occur, the extent and nature of host genetic variability to tuberculosis pathogenesis are unknown. Thus, to better understand the role of host genetic factors in tuberculosis susceptibility, we have tested the contribution of candidate gene variants to tuberculosis susceptibility in three geographically, epidemically, and clinically distinct populations. We chose four candidate genes involved in the innat

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30

Akin, James. "IAP Inhibitors as Novel Immune Adjuvants for Scaffold Based Cancer Vaccines." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467467.

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Inhibitors of apoptosis (IAP) antagonists are nearing approval as promising new candidates for cancer therapy, particularly for solid tumors. Previous work had uncovered the ability of the monomer version of this drug to co-stimulate T cells and enhance anti-tumor immunity when administered systemically in conjunction with B16/GVAX, a model of melanoma immunotherapy. Further published work from multiple labs revealed the ability of these drugs to influence a variety of immune subsets. Given that IAP proteins are known to regulate alternative NFkB downstream of TNFR family members (e.g. GITR, B

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31

Doody, Karen. "T cell protein tyrosine phosphatase in immune system development and disease." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104657.

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The ontogeny of the immune system is orchestrated by a highly organized cell signaling network that ensures the development of multiple hematopoietic lineages and allows them to transduce information from their environment in order to mount appropriate responses to prevent disease. The phosphotyrosine signaling network has developed in higher organisms and is undeniably central to the immune system; alterations in components of this network, such as protein tyrosine phosphatases (PTP), can lead to immunodeficiency, autoimmune disease, and hematopoietic malignancy. The T cell protein tyrosine p

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32

Coulter-Hennekens, Kelsye. "HLA associations with specific immune responses : the Ra5 ragweed allergen model." Thesis, McGill University, 1987. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75370.

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Previous studies have established that sensitivity (IgE antibody response) to Ra5S, a 5 kd protein of short ragweed pollen, is significantly associated with host possession of HLA-Dw2/DR2 (Bias et al., 1979; March et al., 1982a; Coulter, 1983). The present work was undertaken to determine a possible association between HLA and sensitivity to Ra5G, an Ra5S homologue from giant ragweed pollen. The DR2 allele was also implicated in sensitivity to Ra5G, on the basis of co-sensitivity to both proteins (Goodfriend et al., 1985). Further analysis with an enlarged RW allergic population demonstrated t

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33

Rhee, Inmoo. "Roles of protein tyrosine phosphatase PTP-PEST in innate immune cells." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121296.

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PTP-PEST (protein tyrosine phosphatase - proline-, glutamic acid-, serine- and threonine-rich; also named PTPN12) is an intracellular protein tyrosine phosphatase highly expressed in non-immune and immune cells. PTP-PEST was previously reported to be a critical regulator of cytoskeletal reorganization, cell adhesion and migration in non-immune cells. Moreover, PTP-PEST has a role as tumor suppressor in several types of human solid tumors. Recently, the roles of PTP-PEST in immune cells have also been clarified, using a cell type-specific conditional PTP-PEST-deficient mouse. In T cells, PTP-PE

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34

Chang, Xing. "X-Linked FOXP3 & OTC in immune tolerance and autoimmunity." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1149171466.

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35

Laserson, Uri. "High-throughput methods for characterizing the immune repertoire." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/79246.

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Thesis (Ph. D. in Biomedical Engineering and Computational Biology)--Harvard-MIT Program in Health Sciences and Technology, February 2013.<br>"September 2012." Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 147-160).<br>The adaptive immune system is one of the primary mediators in almost every major human disease, including infections, cancer, autoimmunity, and inflammation-based disorders. It fundamentally functions as a molecular classifier, and stores a memory of its previous exposures. However, until recently, methods to unlock this information or to explo

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Nelson, Debra Lynn. "The effect of perfluorodecanoic acid (PFDA) on parameters of the immune systems /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487780393269062.

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Vikberg, Martínez Yolanda. "REGIONAL SPECIALIZATION OF THEADAPTIVE IMMUNE SYSTEM WITHIN THEHUMAN GUT." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-73528.

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Background The human intestine is the largest immune organ in the human body and is constantly exposedto a great number of antigens and bacteria. This requires a balance between tolerogenic andimmunogenic responses to avoid inflammation. The small and large intestine have differentanatomy, physiological functions and are affected differently by diseases. Many studies onintestinal immunity do not distinguish between the small and large intestine, and most studiesare performed on mice. To fully understand human intestinal immunity, there is a need for morestudies on humans that also treat the di

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Chan, Ying Kai. "Interplay of Dengue Virus and the Human Immune Response." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467339.

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RIG-I is a key cytosolic sensor of many RNA viruses, including dengue virus (DV), the most significant arboviral pathogen. Upon viral RNA binding, RIG-I signals via the adaptor protein MAVS, located at mitochondria, to induce the expression of interferons (IFNs), proinflammatory cytokines and interferon-stimulated genes (ISGs), thereby establishing an antiviral state. Among the ISGs, the IFITM proteins are critical for antiviral restriction of numerous pathogenic viruses including DV by inhibiting viral entry. Here, we uncover how DV escapes RIG-I-mediated immunity. The NS3 protein of DV binds

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Glasper, Erica Renee. "Psychobiological factors alter health outcome." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1148415999.

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Spriggs, Tracey Lynn. "MODULATION OF THE HUMORAL IMMUNE RESPONSE BY THE SYMPATHETIC NERVOUS SYSTEM." VCU Scholars Compass, 1994. https://scholarscompass.vcu.edu/etd/5519.

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The immune system is critical for the maintenance of homeostasis. Due to the fact that a coordinated effort between organ systems is required for internal stability, it has been postulated that the immune system interacts with the neuroendocrine system. Clinical, anatomical, and receptor studies have provided evidence for a bi-directional communication between the nervous and immune systems. The goal of the present studies was to determine the potential influence of the sympathetic nervous system (SNS) on the primary antibody forming cell (AFC) response. The adrenergic neurotoxin, 6-hydroxydop

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Gascon, Merlos Mireia 1984. "Persistent organic pollutants, bisphenol A, phthalates and respiratory and immune health in childhood." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/145922.

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Persistent organic pollutants (POPs), bisphenol A (BPA) and pthalates may increase the risk of respiratory infections and allergic diseases in infants and the effects might last until, at least, adolescence. Cytokines and biomarkers of inflammation can provide information of the mechanisms behind such associations. Data from the “Infancia y Medioambiente” (INMA) population-based birth cohort project and from six other existing European birth cohort studies have been used in the present thesis, which also includes a systematic review. Results of the present work, which includes five scientific

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Munblit, Daniel. "Determinants of colostrum and breast milk immune composition and consequences for infant health." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/42364.

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Background: Breast milk is the principal source of nutrition during a critical period of immune programming - maternal and environmental exposures may influence breast milk composition and infant health. Objectives: To examine whether environmental and/or maternal factors influence levels of immune active components in colostrum and breast milk and identify associations between these factors and health outcomes. To examine if colostrum/breast milk immune composition can be grouped into specific 'lactotypes'. Methods: A prospective cohort study of mother/infant pairs in London, Moscow and Veron

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Chakir, Habiba. "Role of interleukin-12 and interleukin-18 in murine immune cell regulation." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/28980.

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Interleukin 12 plays a central role in NK cell activation and CD4 +T cell differentiation. IL-12 acts via a receptor composed of IL-12Rbeta1 and IL-12Rbeta2 subunits. IL-12Rbeta1 plays a primary role in ligand binding whereas IL-12Rbeta2 is responsible for signaling. IL-18 shares some functional activities of IL-12. However, there is a considerable amount of contradictory data in the literature regarding the requirements for IL-12 and IL-18 responsiveness. This work examined the expression of IL-12Rbeta2 on murine NK and T cells and the requirements for acquisition of IL-12/IL-18 responsivenes

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Faingold, Dana. "Immune expression and inhibition of heat shock protein 90 in uveal melanoma." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=92320.

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Uveal melanoma (UM) is the most common intraocular tumor in adults. Despite the increase in diagnostic accuracy over the past several decades and the development of eye saving treatments such as plaque radiotherapy and photon beam therapy, there was no significant change in the prognosis in uveal melanoma due to metastatic disease. Therefore, we started to search for novel therapeutic targets in UM, such as heat shock protein 90 (Hsp90). This protein is a chaperone for several proteins (clients) involved in signal transduction and cell cycle control like kinases and transcription factors and p

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Bennett, Patricia Helen. "Relationality and health : developing a transversal neurotheological account of the pathways linking social connection, immune function, and health outcomes." Thesis, Oxford Brookes University, 2013. https://radar.brookes.ac.uk/radar/items/bc0bd545-799e-455f-b5bc-40d74dcd946a/1/.

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This thesis is a transdisciplinary investigation of the link between social connection and health outcomes. Its twofold aim is to explore the nature of this relationship and build a theoretical model for a possible causal chain between the two, and to develop and deploy a new model for engaging the very different discourses of theology and neuroscience. To this end it draws on both theological reflection and on experimental scientific data from cognitive neuroscience and psychoneuroimmunology. The opening half of the work establishes the wider epistemological and methodological frameworks with

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Minhas, Raman. "Cytokine-dependent hemopoietic cell linker : role in immune-cell receptor signaling." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79052.

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Adaptor proteins provide mechanisms by which extracellular signals are amplified and downstream effector proteins are regulated. Cytokine-dependent hemopoietic cell linker (Clnk), a third member of the SLP-76 family of adaptor molecules, was previously shown to be a positive regulator of TCR signaling. To better understand the role of Clnk in the immune cell signaling network, we first sought to identify additional, unknown, Clnk-binding partners, ultimately confirming the known partners, namely HPK1 and Fyb. Further studies surrounding the Clnk-HPK1 interaction illustrated important bi

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Alter, Galit. "Fate of the HIV-specific immune response starting in primary infection." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84461.

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Two decades into the epidemic caused by the human immunodeficiency virus (HIV) and this virus has infected nearly 1% of the world's population. Highly active antiretroviral therapy (HAART) has transformed the epidemic from a death sentence into a chronic infection. However restricted access, complicated regimens, drug resistance, and long-term toxicities are all impediments to life long therapy for all those infected. These factors stress the need for vaccines and immunotherapeutic strategies that may be used in conjunction with antiretroviral drugs for the optimization of patient care.

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Abd-Elfatah, Hassan Ahmed. "Aspects on maternal immune health during gestation and early postpartum periods in the cow." Doctoral thesis, Universitat de Lleida, 2013. http://hdl.handle.net/10803/104487.

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Aquesta tesi (mitjançant cinc estudis) va ser destinada a investigar factors que tenen un efecte potencial sobre la salut materna durant la gestació i el postpart temprà, tenint en compte la melatonina com una possible millora de la salut i el rendiment de les vaques. En el primer estudi, els factors que afecten els leucòcits perifèrics de la mare, com un indicador d'estat immune, entre els dies 90-210 de gestació van ser, la interacció entre l'edat de la vaca i Neospora caninum, l'estació, la gestació gemelar, la producció de llet i el temps de mostreig. Seguint el sistema immune matern més e

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McMenamin, Paul G. "The biology of immune cells in the eye : implications for development, health and disease." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/3187/.

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The work presented in this thesis is a collection of papers from research spanning over 25 years. The research commenced whilst the candidate was employed in the Tennent Institute of Ophthalmology and later the Department of Anatomy at the University of Glasgow and continued in the School of Anatomy & Human Biology, The University of Western Australia. The research focuses on the biology of immune cells, primarily dendritic cells (DC), macrophages and mast cells, in the context of various components of the eye, including the aqueous outflow pathways, iris, cornea, ciliary body, choroid and ret

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Simpson, Joanne Elizabeth. "Immune regulation induced by apoptotic cells in health and in systemic lupus erythematosus (SLE)." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23515.

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease where failure to remove apoptotic cells, due to a defect in phagocytic cells, or deficient opsonisation, leads to secondary necrosis and the release of DNA and chromatin. The nuclear constituents from apoptotic cells are targeted by autoantibodies, which form immune complexes. Immune complex-mediated TLR9 activation of plasmacytoid dendritic cells (pDCs) and subsequent secretion of interferon (IFN-α) is thought to drive inflammation in SLE. It is currently believed that pDCs do not normally respond to apoptotic cells, as self-D

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