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Journal articles on the topic 'Immune reponse'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

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1

Jonker, M. A., Y. Sano, A. Heneghan, J. Hermsen, and K. Kudsk. "P099 PARENTERAL NUTRITION ELIMINATES SMALL INTESTINE MUCOSAL IMMUNE REPONSE TO INJURY." Clinical Nutrition Supplements 4, no. 2 (2009): 67. http://dx.doi.org/10.1016/s1744-1161(09)70149-8.

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Corrêa, R. B., M. Puccioni-Sohler, S. A. P. Novis, M. S. P. Oliveira, and M. S. M. Carvalho. "5-04-06 Profile of cellular immune reponse among HAM/TSP patients in Rio de Janeiro." Journal of the Neurological Sciences 150 (September 1997): S277. http://dx.doi.org/10.1016/s0022-510x(97)86229-6.

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3

Khalil, Maged, Zili He, Ashish Sangal, et al. "High Dose Glucocorticoids Potentiate the Reponse to Erythropoietin." Blood 108, no. 11 (2006): 3775. http://dx.doi.org/10.1182/blood.v108.11.3775.3775.

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Abstract Introduction: The role of steroids in mammalian erythropoiesis has remained not well defined. At our institution, we have observed cases in which it appears that there is a synergism between Erythropoietin factor and glucocorticoids. In three cases, the patients were being treated for anemia that was slow to respond to erythropoietin, but then had a sudden quick rise in Hemoglobin following concomitant therapy with Glucocorticoids. Case #1 is a 32 year-old black female, with SLE for more than 20 years, lupus nephropathy, end-stage renal disease on maintenance Hemodialysis, for the las

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4

Purow, Benjamin. "Repurposing existing agents as adjunct therapies for glioblastoma." Neuro-Oncology Practice 3, no. 3 (2015): 154–63. http://dx.doi.org/10.1093/nop/npv041.

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AbstractNumerous non-oncologic medications have been found in the last decade to have anti-cancer properties. While the focus in oncology research should clearly remain on deriving new therapeutic strategies, repurposing these existing medications may offer the potential to rapidly enhance the effectiveness of treatment for resistant cancers. Glioblastoma, the most common and lethal brain cancer, is highly resistant to standard therapies and would benefit from even minor improvements in treatment. Numerous agents already in the clinic for non-cancer applications have been found to also possess

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5

Siolas, Despina, Jane Cullis, Antonina Avanzi, et al. "Antitumor activity and immune reponse in CD40 immunotherapy with gemcitabine and nab-paclitaxel in an orthotopic pancreatic cancer mouse model." Journal of Clinical Oncology 34, no. 4_suppl (2016): 271. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.271.

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271 Background: Pancreatic cancer is well known for its aggressive clinical course and resistance to chemotherapy. A Phase I trial of CD40 immunotherapy in combination with gemcitabine demonstrated the combination was safe and achieves tumor responses in patients with pancreatic ductal adenocarcinoma. We investigated the effectiveness of gemcitabine, albumin-bound paclitaxel and CD40 agonist immunotherapy in an orthotopic pancreatic mouse model. Methods: Pancreatic cells obtained from a KrasG12D;Trp53R172H (KPC) genetically engineered mouse were cultivated in cell culture and surgically implan

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6

Hessel, L., A. Garbarg-Chenon, J. L. Fontaine, et al. "Etude de la reponse immune au vaccin rotavirus vivant attenue, souche WC3, chez des enfants de 2 A 12 mois." Médecine et Maladies Infectieuses 19, no. 11 (1989): 627. http://dx.doi.org/10.1016/s0399-077x(89)80071-x.

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7

Lechner, Franziska, John Sullivan, Hans Spiegel, et al. "Why do cytotoxic T lymphocytes fail to eliminate hepatitis C virus? Lessons from studies using major histocompatibility complex class I peptide tetramers." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 355, no. 1400 (2000): 1085–92. http://dx.doi.org/10.1098/rstb.2000.0646.

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Hepatitis C virus (HCV) infection is a major public health problem, affecting an estimated 3% of the world's population, and over 10% in some countries. Infection in most cases becomes persistent, and can lead to hepatic inflammation, fibrosis and liver failure. The T lymphocyte reponse, in particular that mediated by cytotoxic T lymphocytes (CTLs), is likely to be involved in determining the outcome of infection, although its overall role is not clear. The use of major histocompatibility complex (MHC) class I peptide tetrameric complexes (tetramers) to study antiviral CTL responses has revolu

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8

Boussoffara, Thouraya, Mohamed Samir Boubaker, Melika Ben Ahmed, et al. "Histological and immunological differences between zoonotic cutaneous leishmaniasis due to Leishmania major and sporadic cutaneous leishmaniasis due to Leishmania infantum." Parasite 26 (2019): 9. http://dx.doi.org/10.1051/parasite/2019007.

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Lesion features in cutaneous leishmaniasis (CL) depend on the infecting Leishmania species as well as on host immune reponse. In this study, we evaluated the histological and immunological differences between two forms of CL described in Tunisia: zoonotic cutaneous leishmaniasis (ZCL) caused by L. major and sporadic cutaneous leishmaniasis (SCL) caused by L. infantum. Histological analysis showed a mild to moderate infiltrate within ZCL lesions. In contrast, massive infiltration of the dermis was observed within SCL lesions. Contrary to ZCL, infiltrates within SCL lesions were organized and sh

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9

Pratiwi, Rahma Indah, Jusak Nugraha, Betty Agustina Tambunan та Francisca Srioetami Tanoerahardjo. "Respons Sitokin TNF-Α Dan Il-4 Pasca Stimulasi Antigen Fusi Resat-6-CFP-10". Buletin Penelitian Kesehatan 46, № 1 (2018): 53–60. http://dx.doi.org/10.22435/bpk.v46i1.57.

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AbstractProtective immunity of tuberculosis (TB) infection is highly dependent on the balance of Th1 and Th2cytokines. TNF-α cytokines produced by Th1 cell retain a latent status, and IL-4 produced by Th2 aidsin the production of antibodies. The recent development of the vaccine candidates shows that rESAT-6-CFP-10 fusion antigen is specific to induce protective immune responses. The objective of the study wasto determine the immune response. This study used a quasi experimental design in the laboratory in vitrowith cultured PBMC of patients with new cases of pulmonary TB, latent TB and health

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10

Ghanmi, Z., M. Rouabhia, O. Othmane, and P. A. Deschaux. "5.3 Effects of metal ions on cyprinid fish immune response: in vitro effects of Zn2+ and Mn2+ on the mitogenic reponse of carp pronephros lymphocytes." Developmental & Comparative Immunology 13, no. 4 (1989): 398. http://dx.doi.org/10.1016/0145-305x(89)90115-8.

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11

Ferrandina, Gabriella, Patricia S. Braly, Corrado Terranova, et al. "A randomized phase II study assessing an optimized schedule of oregovomab (O) anti-CA125 vaccination with carboplatin paclitaxel (CP) relative to CP alone in front-line treatment of optimally cytoreduced stage III/IV ovarian cancer (EOC)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 5536. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.5536.

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5536 Background: In a phase II study of vaccination schedule in front-line combinatorial treatment of EOC (Braly JIT 2009), simultaneous day infusion dramatically enhanced the magnitude of induced immunity relative to a one week delayed schedule & other schedules historically evaluated. The current study is exploring the clinical & biological effects of the optimized 4 vaccine schedule relative to CP alone. Methods: Stage III/IV EOC patients (pts) optimally debulked to <1cm residual disease with CA125 >2x ULN were randomized to CP+O (cycle 1,3,5, & C5 +12 weeks) vs CP and fol

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12

Fest, Stefan, Kerstin Hilt, Nicole Huebener, et al. "GD2 Peptide Mimotope DNA Vaccines for Anti-Neuroblastoma Immunotherapy." Blood 104, no. 11 (2004): 1350. http://dx.doi.org/10.1182/blood.v104.11.1350.1350.

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Abstract The tumor-associated antigen disialoganglioside-GD2 is expressed on neuroblastoma and melanoma and is an established target for passive immunotherapy. The aim of this study was to develop an active immunization strategy leading to the induction of a humoral anti-GD2 immune response. However, carbohydrates and glycolipids are T cell-independent antigens (TI) and usually evoke a poor immune response in tumor-bearing hosts. Here, we describe the identification, characterization and in vivo efficacy of cyclic peptides mimicking the structure of glycolipid GD2, i.e. GD2 mimotopes, in order

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13

Dhir, Varun. "Mesenchymal Stem Cells: The New Immunosuppressants?" Journal of Postgraduate Medicine, Education and Research 46, no. 2 (2012): 63–68. http://dx.doi.org/10.5005/jp-journals-10028-1015.

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ABSTRACT Mesenchymal stem cells are adult stem cells which can differentiate into cells of mesodermal lineage. osteoblasts, chondroblasts and adipocytes. They have an important property of immunosuppression which is mediated mainly through soluble mediators, like interleukin-1, transforming growth factor-β, nitric oxide, indoleamine 2,3 dioxegenase, etc. They have been shown to suppress both naive and antigen experienced T cells, lead to T cell arrest, and suppress Th1 and Th17 responses. They have also been shown to lead to development of tolerogenic dendritic cells, Th2 response and expansio

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14

Limentani, S. A., M. Campone, T. Dorval, et al. "Evaluation of a recombinant HER2 vaccine: Induction of specific antibodies, T-cells and preliminary activity in metastatic breast cancer patients." Journal of Clinical Oncology 24, no. 18_suppl (2006): 631. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.631.

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631 Background: We designed a vaccine to induce T cells able to recognize epitopes from HER2 and to engender a polyclonal antibody reponse. Methods: The vaccine is a recombinant HER2 protein, including its extra and part of its intra-cellular domains (ECD/ICD), combined with a potent immunologic adjuvant. Cohorts of patients with Stage II/III breast cancer (BC) received 20, 100 or 500 μg in the adjuvant setting. Treatment comprised of six vaccinations over 14 weeks, for the 500-μg dose, recall injections were given on weeks 34 and 38. The trial was extended to include an alternative vaccinatio

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15

Kuo, Yuh-Chi, Wei-Jern Tsai, Hsiang-Chen Meng, Wei-Perng Chen, Ling-Yu Yang, and Ching-Yuang Lin. "Immune reponses in human mesangial cells regulated." Life Sciences 68, no. 11 (2001): 1271–86. http://dx.doi.org/10.1016/s0024-3205(00)01033-x.

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16

Bystryn, J. C., R. Oratz, M. Harris, D. Roses, and R. O. Perelman. "Clinically beneficial immune reponses to melanoma vaccine treatment." Melanoma Research 3, no. 1 (1993): 30. http://dx.doi.org/10.1097/00008390-199303000-00100.

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17

Liu, Qi, Momina Mazhar, and Lloyd S. Miller. "Immune and Inflammatory Reponses to Staphylococcus aureus Skin Infections." Current Dermatology Reports 7, no. 4 (2018): 338–49. http://dx.doi.org/10.1007/s13671-018-0235-8.

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18

Parrot, A., G. Voiriot, A. Canellas, et al. "Hémorragies intra-alvéolaires." Médecine Intensive Réanimation 27, no. 4 (2018): 331–43. http://dx.doi.org/10.3166/rea-2018-0060.

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L’hémorragie intra-alvéolaire (HIA), maladie rare, est une urgence thérapeutique, car elle peut conduire rapidement vers une insuffisance respiratoire aiguë asphyxiante avec décès. La triade, hémoptysie–anémie–infiltrat radiologique, suggère le diagnostic d’HIA, mais elle peut manquer dans deux tiers des cas, y compris chez des patients en détresse respiratoire. La tomodensitométrie thoracique peut aider dans les formes atypiques. Le diagnostic d’HIA repose sur la réalisation d’un lavage bronchoalvéolaire. Les étiologies en sont très nombreuses. Il importera de séparer, en urgence, les HIA d’o

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19

De Castro, Nathalie, Maryvonnick Carmagnat, Solen Kernéis, Catherine Scieux, Claire Rabian, and Jean-Michel Molina. "Varicella-Zoster Virus-Specific Cell-Mediated Immune Reponses in HIV-Infected Adults." AIDS Research and Human Retroviruses 27, no. 10 (2011): 1089–97. http://dx.doi.org/10.1089/aid.2010.0340.

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20

Li-Kim-Moy, Jean, Nicholas Wood, Cheryl Jones, Kristine Macartney, and Robert Booy. "Impact of Fever and Antipyretic Use on Influenza Vaccine Immune Reponses in Children." Pediatric Infectious Disease Journal 37, no. 10 (2018): 971–75. http://dx.doi.org/10.1097/inf.0000000000001949.

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21

Han, G., H. Liu, W. Tan, et al. "Differential Activation of Th1/Th2 Immune Reponses in Murine Radiation Induced Lung Injury." International Journal of Radiation Oncology*Biology*Physics 93, no. 3 (2015): E510—E511. http://dx.doi.org/10.1016/j.ijrobp.2015.07.1853.

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22

Arellano, Javier, Carolina Carrasco, and Carolina García. "A report of successful management with simvastatin plus ezetimibe in alopecia areata." Medwave 20, no. 10 (2020): e8053-e8053. http://dx.doi.org/10.5867/medwave.2020.10.8053.

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Alopecia areata is a common type of non-scarring alo¬pecia. Although the exact pathogenesis remains elusive, alopecia areata is thought to have a multifactorial etiology described as an interplay of genetic predisposition and environmental exposures. In patients with genetic susceptibility, stress, infection, and microtrauma have been documented to decrease immunosuppressive cytokines that generally maintain the hair follicle's immune privilege. There is currently no curative therapy for alopecia areata, although some treatments can induce hair growth in a percentage of patients. It has been p

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23

Yan, Qingsheng, Shilpee Dutt, Rong Xu, et al. "The BBAP E3 Ligase Monoubiquitylates Histone H4 at Lysine 91 and Selectively Modulates the DNA Damage Response in Chemotherapy-Resistant Lymphomas." Blood 114, no. 22 (2009): 3958. http://dx.doi.org/10.1182/blood.v114.22.3958.3958.

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Abstract Abstract 3958 Poster Board III-894 Although the BBAP E3 ligase and its binding partner, BAL, are overexpressed in chemotherapy-resistant diffuse large B-cell lymphomas (DLBCLs), the role of these proteins in response to DNA damage remains undefined. The BBAP and BAL1 genes are located on chromosome 3q21 in a head-to-head orientation and regulated by the same gIFN-responsive bidirectional promoter. These findings are of note because BBAP and BAL1 are most abundant in DLBCLs with a prominent, but ineffective, immune/inflammatory infiltrate and increased gIFN production. Since BAL protei

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24

Vos, G. J., and P. R. Gardiner. "Parasite-specific antibody reponses of responses of ruminants infected withTrypanosoma vivax." Parasitology 100, no. 1 (1990): 93–100. http://dx.doi.org/10.1017/s0031182000060157.

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SummarySera from goats and cattle that were infected with twoTrypanosoma vivaxclones (ILDat 1.2 and ILDat 2.1) derived from different stocks were analysed for antibody activity against the variable surface glycoproteins (VSGs) of the infecting clones by enzyme-linked immune assays (ELISA) and immune lysis. To obtain purified VSG, lysed trypanosomes were separated on dodecyl sulphate-polyacrylamide gels. The gels were copper stained and the VSG protein band was excised from the gel. After destaining, the proteins were electroeluted from the gel slices and used as antigens in ELISA. High titres

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25

Fang, Zhu, and Wei Junfang. "A Novel Parameter Optimization Algorithm Based on Immune Memory Clone Strategy." International Journal of Advanced Pervasive and Ubiquitous Computing 4, no. 3 (2012): 102–8. http://dx.doi.org/10.4018/japuc.2012070107.

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The performance of support vector machine (SVM) depends on the selection of model parameters, however, the selection of SVM model parameters more depends on the empirical value. According to the deficiency, this paper proposes a parameters optimization method of support vector machine based on immune memory clone strategy (IMC). This method can solve the multi-peak model parameters selection problem better which is introduced by n-folded cross-verification. Tests on standard datasets show that this method has higher precision and faster optimization speed compared with other four methods. The

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Kostine, Marie, Aurélien Marabelle, Thierry Schaeverbeke, and Maria Kfoury. "Les limites des inhibiteurs de points de contrôle immunitaire et la gestion de leur toxicité." médecine/sciences 35, no. 12 (2019): 949–56. http://dx.doi.org/10.1051/medsci/2019191.

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L’immunothérapie représente désormais un des piliers de la prise en charge du cancer, notamment avec l’arrivée des inhibiteurs de points de contrôle (checkpoint) immunitaire (ICI, immune checkpoint inhibitors). Ces anticorps thérapeutiques ciblent ces co-signaux inhibiteurs entre cellules tumorales ou cellules présentatrices d’antigènes et lymphocytes T, activant ou réactivant ainsi une immunité cellulaire T anti-tumorale. Mais la survenue d’une toxicité immunologique, qui peut concerner tous les organes, représente le facteur limitant dans le développement clinique de ces anticorps. La gestio

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27

Michel, J. P., M. Cadoz, F. Denis, L. Hessel, M. Mounier, and G. Shiffman. "Comparaison des reponses immunes au vaccin pneumococcique 23 valent entre adultes jeunes et personnes agees." Médecine et Maladies Infectieuses 18 (May 1988): 406. http://dx.doi.org/10.1016/s0399-077x(88)80322-6.

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28

Wang, Anqi, Lipei Sun, Mingshu Wang, et al. "Identification of IFITM1 and IFITM3 in Goose: Gene Structure, Expression Patterns, and Immune Reponses against Tembusu Virus Infection." BioMed Research International 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/5149062.

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As interferon-stimulated genes (ISGs), interferon-inducible transmembrane proteins 1 and 3 (IFITM1 and IFITM3) can effectively inhibit the replication of multiple viruses. Here, goose IFITM1 and IFITM3 were cloned and identified for the first time. The two proteins share the same topological structure and several important sites critical for the antiviral functions in other species are conserved in the goose. Goose IFITM1 and IFITM3 are most closely related to their respective orthologs in ducks; these proteins exhibited high mRNA transcript levels in immune-related tissues, including the thym

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29

Zhu, Fang, and Jun Fang Wei. "SVM Parameter Optimization Based on Immune Memory Clone Strategy and Application in Bus Passenger Flow Counting." Advanced Engineering Forum 6-7 (September 2012): 694–99. http://dx.doi.org/10.4028/www.scientific.net/aef.6-7.694.

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The performance of support vector machine (SVM) depends on the selection of model parameters, however, the selection of SVM model parameters more depends on the empirical value. According to the above deficiency, this paper proposed a parameters optimization method of support vector machine based on immune memory clone strategy (IMC). This method can solve the multi-peak model parameters selection problem better which is introduced by n-folded cross-verification. Tests on standard datasets show that this method has higher precision and faster optimization speed compared with other four methods

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30

Fang, Zhu, and Wei Junfang. "SVM Parameter Optimization based on Immune Memory Clone Strategy and Application in Bus Passenger Flow Counting." International Journal of Advanced Pervasive and Ubiquitous Computing 4, no. 4 (2012): 74–80. http://dx.doi.org/10.4018/japuc.2012100108.

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The performance of support vector mchine (SVM) depends on the selection of model parameters, however, the selection of SVM model parameters more depends on the empirical value. According to the above deficiency, this paper proposed a parameters optimization method of support vector machine based on immune memory clone strategy (IMC). This method can solve the multi-peak model parameters selection problem better which is introduced by n-folded cross-verification. Tests on standard datasets show that this method has higher precision and faster optimization speed compared with other four methods.

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31

Kuwata, Takeo, Russell Byrum, Sonya Whitted, et al. "A Rapid Progressor-Specific Variant Clone of Simian Immunodeficiency Virus Replicates Efficiently In Vivo Only in the Absence of Immune Reponses." Journal of Virology 81, no. 17 (2007): 8891–904. http://dx.doi.org/10.1128/jvi.00614-07.

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ABSTRACT A subset of simian immunodeficiency virus (SIV)-infected macaques progresses rapidly to disease with transient SIV-specific immune responses and high viral loads. Unique SIV variants with convergent Env mutations evolve in these rapid progressor (RP) macaques. To address the pathogenic significance of RP-specific variants, we generated infectious molecular clones from the terminal-phase plasma of an RP macaque. Inoculation of macaques with a representative clone, SIVsmH635FC, resulted in a persistent viremia, comparable to that produced by pathogenic SIVsmE543-3, and a chronic disease

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32

Pagliuca, Simona, Flore Sicre de Fontbrune, Serena Marotta, et al. "Aplastic Anemia in the Context of Hemolytic Paroxysmal Nocturnal Hemoglobinuria: Feasibility of Antibody-Based Intensive Immunosuppression during Eculizumab Treatment." Blood 128, no. 22 (2016): 5074. http://dx.doi.org/10.1182/blood.v128.22.5074.5074.

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Abstract Paroxysmal nocturnal hemoglobinuria (PNH) may present as hemolytic (classical PNH) or aplastic (AA/PNH syndrome) PNH. While classical PNH patients requires anti-complement treatment (eculizumab), the treatment of AA/PNH patients should target their bone marrow failure (BMF) by immunosuppression (IST), or even bone marrow transplantation (BMT). However, in a few patients clinically meaningful AA and hemolysis may be concomitant, eventually justifying both IST and eculizumab. To date there is no standard treatment for this rare condition. Here we investigated the prevalence of this cond

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33

Martinez-Prat, L., M. A. Aure, C. Bentow, D. Lucia, M. Lopez-Hoyos, and M. Mahler. "OP0118 DECIPHERING THE ANTI-PROTEIN-ARGININE DEIMINASE (PAD) RESPONSE IDENTIFIES PAD1 AND PAD6 AS NOVEL AUTOANTIGENS IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 78–79. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2853.

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Background:Protein-arginine deiminase (PAD) 4 enzymes play a central role in the pathogenesis of rheumatoid arthritis (RA) and represents an antigenic target. Among the five known family members (PAD1, PAD2, PAD3, PAD4 and PAD6), only PAD2, PAD3 and PAD4 have been described to have autoantigenic properties. Furtheremore, very little is known on the the isotype usage of these autoantibodies. Understanding the molecular basis of the anti-PAD antibody reponse has the potential to open novel approaches for precision medicine in RA.Objectives:The objectives of this study were to screen for the pres

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SAUCIER, L., M. JULIEN, F. CHEÓUR, R. LETARTE, and J. GOULET. "Effect of Feeding Lactic Acid Bacteria and Fermented Milk on Specific and Nonspecific Immune Reponses of Mice Infected With Klebsiella pneumoniae AD-1." Journal of Food Protection 55, no. 8 (1992): 595–600. http://dx.doi.org/10.4315/0362-028x-55.8.595.

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The diets of six groups of weaned mice were supplemented with ultra high temperature (UHT) milk containing a washed suspension of lactic acid bacteria (mixture of 8 strains) or with UHT milk fermented by the same strains and heat-treated or not. Control groups received physiological saline or UHT milk only. The mice were infected intranasally by Klebsiella pneumoniae AD-1 on the 13th d of feeding. The effect on the immune system (specific and nonspecific) before and after infection was evaluated by measuring the phagocytosis of alveolar macrophages (using zymosan particles) and by measuring of

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Salerno, Dominic M., Barbara Hoffman, and Dan A. Liebermann. "Gadd45 Null Mice and Neutrophils/Macrophages Derived From the Bone Marrow of These Mice Exhibit Impaired Innate-Immune/Inflammatory Reponses." Blood 114, no. 22 (2009): 1350. http://dx.doi.org/10.1182/blood.v114.22.1350.1350.

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Abstract Abstract 1350 Poster Board I-372 Stress sensor Gadd45 proteins modulate p38-NF-Kb and JNK signaling, which play major roles in leukocyte activation and innate immunity. We have previously documentedthat under conditions of hematological stress, notably acute stimulation with cytokines or inflammation, both gadd45a-deficient and gadd45b-deficient mice exhibited impaired inflammatory responses as indicated by lower percentages of Gr-1-positive cells in the BM and lower numbers of myeloid cells in peritoneal exudates (Gupta et. al Oncogene 25:5539-46, 2006). Recent evidence has implicate

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&NA;. "GENERATION OF A NEW RABBIT ANTI-HUMAN LEUKOCYTE POLYCLONAL ANTIBODY AND ITS POTENTIAL THERAPEUTIC APPLICATION IN PREVENTING ALLO-IMMUNE REPONSES." Transplantation 82, Suppl 2 (2006): 138. http://dx.doi.org/10.1097/00007890-200607152-00215.

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37

Heyman, M. "Evaluation of the impact of food technology on the allergenicity of cow’s milk proteins." Proceedings of the Nutrition Society 58, no. 3 (1999): 587–92. http://dx.doi.org/10.1017/s0029665199000774.

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The quantitative evaluation of the allergenicity of food proteins and the clinical tolerance towards antigens are problems the food industry and the clinicians have to face. The allergenicity of a protein depends on multiple factors, including the stability to digestion and the interaction with the intestinal environment. In addition to the possible reduction in allergenicity by technological treatments such as heat and enzymic hydrolysis, the complex interactions existing between the antigens, the intestinal epithelium and the underlying immune system, as well as the individual susceptibility

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Bertinetti, Cristina M., and Hendrik Veelken. "Characterization of Cellular Immune Responses to a Recombinant Idiotype Vaccine by ELISPOT and Identification of MHC Class I-Restricted T Cell Epitopes by Peptide Mapping." Blood 104, no. 11 (2004): 1409. http://dx.doi.org/10.1182/blood.v104.11.1409.1409.

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Abstract Induction of tumor-specific immune responses by idiotype vaccination is a promising strategy for biological therapy of indolent B cell lymphomas. In a previous report, we have described immune responses in a subset of patients participating in a phase I clinical trial primarily designed to demonstrate safety and efficacy of a recombinant idiotype vaccine (Veelken et al., ASH abstract #3342, 2003). In this trial, B-NHL patients who had relapsed after standard chemotherapy received repetitive intradermal vaccinations with recombinant idiotype Fab fragment derived from their tumor mixed

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39

Calmettes, Marion, Thibaut Girardot, and Thomas Rimmelé. "Épuration extra-corporelle et immunomodulation dans le sepsis." Médecine Intensive Réanimation 29, no. 2 (2020): 75–85. http://dx.doi.org/10.37051/mir-00009.

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Le choc septique est fréquent et représente la première cause de mortalité en réanimation. Malgré des recommandations internationales mises à jour régulièrement (Surviving Sepsis Campaign) et les progrès de la réanimation, la mortalité reste très élevée (jusqu’à 40%), en partie du fait des conséquences d’une réponse immuno-inflammatoire de l’hôte « dérégulée ». Le rationnel physiopathologique des techniques extra-corporelles d’immunomodulation dans le choc septique repose sur un meilleur contrôle de cette réponse de l’hôte. De nombreuses techniques sont proposées, certaines combinant l’élimina

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El-Kassas, Seham, Safaa E. Abdo, Karima El-Naggar, Walied Abdo, Abeer A. K. Kirrella, and Toufic O. Nashar. "Ameliorative effect of dietary supplementation of copper oxide nanoparticles on inflammatory and immune reponses in commercial broiler under normal and heat-stress housing conditions." Journal of Thermal Biology 78 (December 2018): 235–46. http://dx.doi.org/10.1016/j.jtherbio.2018.10.009.

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Williams, Yvette J., Suzanne M. Rea, Sam Popovski, et al. "Reponses of sheep to a vaccination of entodinial or mixed rumen protozoal antigens to reduce rumen protozoal numbers." British Journal of Nutrition 99, no. 1 (2007): 100–109. http://dx.doi.org/10.1017/s0007114507801553.

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Two rumen protozoa vaccine formulations containing either whole fixed Entodinium or mixed rumen protozoa cells were tested on Merino sheep with the aim of decreasing the number and/or activity of protozoa in the rumen. Negative control (no antigen) and positive control (Tetrahymena corlissi antigens) treatments were also included in the experiment. Blood and saliva were sampled to measure the specific immune response. Protozoal numbers in the rumen were monitored by microscopic counts. Vaccination with protozoal formulations resulted in the presence of specific IgG in plasma and saliva, but sa

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Davis, Andrew A., Young Kwang Chae, Sarita Agte, et al. "Association of tumor mutational burden with smoking and mutation status in non-small cell lung cancer (NSCLC)." Journal of Clinical Oncology 35, no. 7_suppl (2017): 24. http://dx.doi.org/10.1200/jco.2017.35.7_suppl.24.

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24 Background: Reponses to immunotherapy have been observed in multiple solid tumors including non-small cell lung cancer (NSCLC). Identifying optimal biomarkers for response to anti-PD-1/PD-L1 therapies remains critical. Tumor mutational burden (TMB) may indicate genomic instability and potential neoantigen binding sites to activated effector T cells. Methods: We retrospectively examined tumor mutational burden (TMB) using next-generation sequencing (Foundation Medicine) for 83 patients with NSCLC in our institution. TMB included both coding and non-coding regions, but excluded potentially fu

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Tanguay, Daniel. "Le problème de la clôture politique selon Daniel Jacques." Dialogue 40, no. 1 (2001): 147–66. http://dx.doi.org/10.1017/s001221730004909x.

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L'attachement aux coutumes locales tient à tous les sentiments désintéressés, nobles et pieux. Quelle politique deplorable que celle qui en fait de la rébellion! Qu'arrive-t-il? Que dans tous les États où l'on détruit ainsi toute vie partielle, un petit État se forme au centre: dans la capitale s'agglomèrent tous les intérêts: là vont s'agiter toutes les ambitions: le reste est immobile. Les individus, perdus dans un isolement contre nature, étrangers au lieu de leur naissance, sans contact avec le passé, ne vivant que dans un présent rapide, et jetés comme des atomes sur une plaine immense et

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Strauss, Julius, Fadi S. Braiteh, Emiliano Calvo та ін. "Evaluation of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in cervical cancer: Data from phase 1 and phase 2 studies." Journal of Clinical Oncology 39, № 15_suppl (2021): 5509. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.5509.

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5509 Background: The accelerated FDA approval of pembrolizumab validated the efficacy of anti–PD-(L)1 therapy for pts with recurrent/metastatic cervical cancer; however, the objective response rate (ORR) with pembrolizumab was 14.3% in pts with PD-L1 expressing tumors. HPV infection is implicated in > 95% of cervical cancers and is linked to upregulation of TGF-β signaling. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the TGF-βRII receptor (a TGF-β “trap”) fused to a human IgG1 mAb blocking PD-L1. We report pooled safety and efficac

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RAVINET, N., C. CHARTIER, H. HOSTE, et al. "Enjeux et outils du traitement raisonné contre les strongles gastro-intestinaux chez les bovins et les petits ruminants." INRA Productions Animales 30, no. 1 (2018): 57–76. http://dx.doi.org/10.20870/productions-animales.2017.30.1.2233.

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Chez les ruminants élevés au pâturage, les strongles gastro-intestinaux (SGI) peuvent induire des pertes de production, voire des atteintes cliniques chez les animaux non immuns. Le contrôle de l’infestation repose essentiellement sur les traitements anthelminthiques (AH) administrés fréquemment sans évaluation préalable de la réalité du risque parasitaire. Cette synthèse vise tout d’abord à exposer les principaux risques associés à ce recours insuffisamment raisonné aux AH : apparition de populations de parasites résistants aux AH, écotoxicité pour la microfaune prairiale dégradant les fèces,

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Friedman, S. M., A. Al-Den, and D. Porplycia. "P051: Management of subcutaneous abscesses in the emergency department." CJEM 20, S1 (2018): S74—S75. http://dx.doi.org/10.1017/cem.2018.249.

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Introduction: We sought to characterize the management of uncomplicated subcutaneous abscesses (SA) by Canadian emergency physicians (EPs). Methods: Cross-sectional study of CAEP membership. Subjects were emailed an invitation to an online survey, and two biweekly reminders. Wilcoxon rank sum test was used for association with age, and Chi Square and Fischers exact test were used for binary variables. Results: Response rate was 21.2 % (392 Reponses / 1850 surveyed). Duration of practice ranged from 30.2 % practising <= 5 years, to 25.7% practising >= 20 years. Teaching setting was descri

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Dorfel, Daniela, Barbara Beck, Christiane Geiger, et al. "The TLR7/8 Ligand R848 Is Superior In Generation of Monocyte Derived Dendritic Cells From AML Patients for the Induction of Potent T and NK Cell Immune Responses." Blood 116, no. 21 (2010): 2195. http://dx.doi.org/10.1182/blood.v116.21.2195.2195.

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Abstract Abstract 2195 Introduction: Therapeutic vaccination with dendritic cells (DC) is currently considered as an investigational therapy in acute myeloid leukemia (AML) for eradication of minimal residual disease (MRD). Dendritic cells derived from autologous peripheral blood monocytes have been tested as cellular adjuvants for therapeutic vaccination of malignancies and proven feasibility and safety, but overall clinical response rates remain very low. The vast majority of DCs used for clinical trials were differentiated with a standard maturation cocktail composed of the cytokines TNF-a,

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Schutz, Natalia, Jorge Arbelbide, Walter Skordo, Susana Viñuales, Elsa Nucifora, and Dorotea Beatriz Fantl. "Rituximab Treatment for Autoinmune Hemolitic Diseases,." Blood 118, no. 21 (2011): 3168. http://dx.doi.org/10.1182/blood.v118.21.3168.3168.

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Abstract Abstract 3168 INTRODUCTION: Steroids are the first line treatment for Autoimmune Hemolytic Anemia (AHA) and Immune Thrombocytopenic Purpura (ITP). Second line treatments for patients with partial reponses or steroid dependence are controversial and have changed during the last decades. Several authors have proposed the use of Rituximab in these patients although published data are still sparse. OBJECTIVES: We reviewed the medical records of all the patients treated in our hospital with Rituximab in order to evaluate the response rate and security of this treatment. MATHERIALS AND METH

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Rapoport, Aaron P., Stephan A. Grupp, Edward A. Stadtmauer, et al. "Rapid T Cell Recovery and Possible Auto-GVHD Following Adoptive Transfer of Ex-Vivo Costimulated Autologous T Cells at Day +2 Post-Transplant." Blood 110, no. 11 (2007): 769. http://dx.doi.org/10.1182/blood.v110.11.769.769.

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Abstract Retrospective studies suggest that rapid lymphocyte recovery following autologous stem cell transplants (SCT) may be associated with better outcomes. Previously we showed that adoptive transfer of in-vivo vaccine-primed and ex-vivo (anti-CD3/anti-CD28) costimulated autologous T cells (ex-T) at about day 14 post-transplant increased CD4 and CD8 T cell counts at day 42 post-transplant and induced pneumococcal conjugate vaccine-directed T and B-cell responses [Rapoport et al, Nature Medicine, 2005]. In 2 current studies, we are further investigating the impact of ex-vivo costimulated aut

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Andrijašević, Nemanja. "George Radin on Bishop Dr. Nicholai Velimirovich and the Serbian Orthodox Church in America." Nicholai Studies: International Journal for Research of Theological and Ecclesiastical Contribution of Nicholai Velimirovich I, no. 2 (2021): 369–94. http://dx.doi.org/10.46825/icholaistudies/ns.2021.1.2.369-394.

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Abstract: George Radin (Đorđe Radin, 1896–1981) was one of the numerous Serbian emigrants in the USA in the period right before WW2. He studied at the most eminent American Universities and had become an attorney, then a lawyer and finally an expert in international law. He managed to achieve great success and expertise in the field of American foreign politics and diplomacy. In the period between the two World Wars, he met Bishop Dr. Nicholai Velimirovich who made a strong impression on him. He was the Bishop’s guide across the USA during his two visits there: in 1920 and in 1927. During his

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