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Journal articles on the topic 'Immune response Molecular aspects'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2023

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1

AS, Dr Maniyammai, Dr Amudha M, Dr Renuka Devi R, Dr Esther Nalini H, and Dr Arun Kumar Prasad. "Adaptive immune response: Molecular aspects of periodontal disease." International Journal of Applied Dental Sciences 7, no. 4 (October 1, 2021): 89–92. http://dx.doi.org/10.22271/oral.2021.v7.i4b.1356.

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2

Goodman, Jesse L. "Molecular Aspects of Immune Response in Infectious Diseases." Clinical Infectious Diseases 13, no. 3 (May 1, 1991): 530. http://dx.doi.org/10.1093/clinids/13.3.530-a.

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3

Inman, R. D. "Immunogenetic aspects of host immune response." Canadian Journal of Microbiology 34, no. 3 (March 1, 1988): 319–22. http://dx.doi.org/10.1139/m88-058.

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The central role of histocompatibility leukocyte antigens (HLA) class II molecules in antigen presentation has received great attention in recent years, yet class I molecules have been defined as primarily functioning as a restriction element for cytotoxic T cell killing of virus-infected cells. Extensive clinical evidence, however, indicates that the HLA class I genes are strongly associated with nonseptic complications of enteric and genitourinary bacterial infections. Ninety percent of patients with Reiter's syndrome and reactive arthritis are positive for HLA-B27, yet the mechanism of dise

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4

Jeffries, Donald. "Book Review: Molecular Aspects of Immune Response and Infectious Diseases." International Journal of STD & AIDS 2, no. 3 (May 1991): 218. http://dx.doi.org/10.1177/095646249100200322.

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5

Stetson, C. A., and E. Jensen. "HUMORAL ASPECTS OF THE IMMUNE RESPONSE TO HOMOGRAFTS *." Annals of the New York Academy of Sciences 87, no. 1 (December 15, 2006): 249–57. http://dx.doi.org/10.1111/j.1749-6632.1960.tb23198.x.

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6

INNES, ELISABETH A., DAVID BUXTON, STEPHEN MALEY, STEPHEN WRIGHT, JOANNE MARKS, IRMA ESTEBAN, ALISTAIR RAE, ALEX SCHOCK, and JONATHAN WASTLING. "Neosporosis: Aspects of Epidemiology and Host Immune Response." Annals of the New York Academy of Sciences 916, no. 1 (January 25, 2006): 93–101. http://dx.doi.org/10.1111/j.1749-6632.2000.tb05278.x.

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7

Sonenshine, Daniel, E. "Molecular characterization and related aspects of the innate immune response in ticks." Frontiers in Bioscience Volume, no. 13 (2008): 7046. http://dx.doi.org/10.2741/3209.

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8

Nikolic, Dejan, Milena Jankovic, Bojana Petrovic, and Ivana Novakovic. "Genetic Aspects of Inflammation and Immune Response in Stroke." International Journal of Molecular Sciences 21, no. 19 (October 8, 2020): 7409. http://dx.doi.org/10.3390/ijms21197409.

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Genetic determinants play important role in the complex processes of inflammation and immune response in stroke and could be studied in different ways. Inflammation and immunomodulation are associated with repair processes in ischemic stroke, and together with the concept of preconditioning are promising modes of stroke treatment. One of the important aspects to be considered in the recovery of patients after the stroke is a genetic predisposition, which has been studied extensively. Polymorphisms in a number of candidate genes, such as IL-6, BDNF, COX2, CYPC19, and GPIIIa could be associated

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Petean, Igor Bassi Ferreira, Alice Corrêa Silva-Sousa, Tamara Justiniano Cronenbold, Jardel Francisco Mazzi-Chaves, Lea Assed Bezerra da Silva, Raquel Assed Bezerra Segato, Guilherme Assed Piedade de Castro, Erika Calvano Kuchler, Francisco Wanderley Garcia Paula-Silva, and Manoel Damião Sousa-Neto. "Genetic, Cellular and Molecular Aspects involved in Apical Periodontitis." Brazilian Dental Journal 33, no. 4 (August 2022): 1–11. http://dx.doi.org/10.1590/0103-6440202205113.

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Abstract The development, establishment and repair of apical periodontitis (AP) is dependent of several factors, which include host susceptibility, microbial infection, immune response, quality of root canal treatment and organism's ability to repair. The understanding of genetic contributions to the risk of developing AP and presenting persistent AP has been extensively explored in modern Endodontics. Thus, this article aims to provide a review of the literature regarding the biochemical mediators involved in immune response signaling, osteoclastogenesis and bone neoformation, as the genetic

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McNamara, Mairéad G., Jean-Yves Scoazec, and Thomas Walter. "Extrapulmonary poorly differentiated NECs, including molecular and immune aspects." Endocrine-Related Cancer 27, no. 7 (July 2020): R219—R238. http://dx.doi.org/10.1530/erc-19-0483.

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Patients with extrapulmonary poorly differentiated neuroendocrine carcinomas (EP-PD-NECs) have a poor prognosis. Surgery is offered for those with localised disease, but the majority of patients present with advanced disease. Treatment strategies adopted are analogous to that of high grade NECs of the lung, with platinum/etoposide-based regimens advocated in the first-line setting for advanced disease. There is no standard second-line therapy. Research into their molecular and immune pathways may pave the way for novel drug discovery. The molecular drivers of NEC are best identified in small c

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de Vries, Stefan P. W., Hester J. Bootsma, John P. Hays, and Peter W. M. Hermans. "Molecular Aspects of Moraxella catarrhalis Pathogenesis." Microbiology and Molecular Biology Reviews 73, no. 3 (September 2009): 389–406. http://dx.doi.org/10.1128/mmbr.00007-09.

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SUMMARY In recent years, Moraxella catarrhalis has established its position as an important human mucosal pathogen, no longer being regarded as just a commensal bacterium. Further, current research in the field has led to a better understanding of the molecular mechanisms involved in M. catarrhalis pathogenesis, including mechanisms associated with cellular adherence, target cell invasion, modulation of the host's immune response, and metabolism. Additionally, in order to be successful in the host, M. catarrhalis has to be able to interact and compete with the commensal flora and overcome stre

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12

Zav'Yalov, VLADIMIR P., ALEXANDER I. Denesyuk, JUHANI Lundell, and TIMO Korpela. "Some new aspects of molecular mechanisms of cyclosporin A effect on immune response." APMIS 103, no. 1-6 (January 1995): 401–15. http://dx.doi.org/10.1111/j.1699-0463.1995.tb01125.x.

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13

Robinson, John A., and Kerstin Moehle. "Structural aspects of molecular recognition in the immune system. Part II: Pattern recognition receptors (IUPAC Technical Report)." Pure and Applied Chemistry 86, no. 10 (October 21, 2014): 1483–538. http://dx.doi.org/10.1515/pac-2013-1026.

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Abstract The vertebrate immune system uses pattern recognition receptors (PRRs) to detect a large variety of molecular signatures (pathogen-associated molecular patterns, PAMPs) from a broad range of different invading pathogens. The PAMPs range in size from relatively small molecules, to others of intermediate size such as bacterial lipopolysaccharide, lipopeptides, and oligosaccharides, to macromolecules such as viral DNA, RNA, and pathogen-derived proteins such as flagellin. Underlying this functional diversity of PRRs is a surprisingly small number of structurally distinct protein folds th

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14

Cohen-Inbar, Or, and Menashe Zaaroor. "Immunological Aspects of Malignant Gliomas." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 43, no. 4 (April 13, 2016): 494–502. http://dx.doi.org/10.1017/cjn.2016.34.

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AbstractGlioblastoma Multiforme (GBM) is the most common malignant primary brain neoplasm having a mean survival time of <24 months. This figure remains constant, despite significant progress in medical research and treatment. The lack of an efficient anti-tumor immune response and the micro-invasive nature of the glioma malignant cells have been explained by a multitude of immune-suppressive mechanisms, proven in different models. These immune-resistant capabilities of the tumor result in a complex interplay this tumor shares with the immune system. We present a short review on the immunol

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Teras, Jüri, Michael J. Carr, Jonathan S. Zager, and Hidde M. Kroon. "Molecular Aspects of the Isolated Limb Infusion Procedure." Biomedicines 9, no. 2 (February 7, 2021): 163. http://dx.doi.org/10.3390/biomedicines9020163.

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For decades, isolated limb infusion (ILI) and hyperthermic isolated limb perfusion (HILP) have been used to treat melanoma in-transit metastases and unresectable sarcoma confined to the limb utilizing the effect of loco-regional high-dose chemotherapy to the isolated limb. Both procedures are able to provide high response rates in patients with numerous or bulky lesions in whom other loco-regional treatments are becoming ineffective. In comparison to systemic therapies, on the other hand, ILI and HILP have the advantage of not being associated with systemic side-effects. Although in principle

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Kalaria, R. N., M. Harshbarger-Kelly, D. L. Cohen, and D. R. D. Premkumar. "Molecular aspects of inflammatory and immune responses in Alzheimer's disease." Neurobiology of Aging 17, no. 5 (September 1996): 687–93. http://dx.doi.org/10.1016/0197-4580(96)00114-5.

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17

Nedoszytko, Bogusław, Edyta Reszka, Danuta Gutowska-Owsiak, Magdalena Trzeciak, Magdalena Lange, Justyna Jarczak, Marek Niedoszytko, et al. "Genetic and Epigenetic Aspects of Atopic Dermatitis." International Journal of Molecular Sciences 21, no. 18 (September 4, 2020): 6484. http://dx.doi.org/10.3390/ijms21186484.

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Atopic dermatitis is a heterogeneous disease, in which the pathogenesis is associated with mutations in genes encoding epidermal structural proteins, barrier enzymes, and their inhibitors; the role of genes regulating innate and adaptive immune responses and environmental factors inducing the disease is also noted. Recent studies point to the key role of epigenetic changes in the development of the disease. Epigenetic modifications are mainly mediated by DNA methylation, histone acetylation, and the action of specific non-coding RNAs. It has been documented that the profile of epigenetic chang

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Kubistova, Zuzana, Frantisek Mrazek, and Martin Petrek. "POLYMORPHISMS OF THE IMMUNE RESPONSE GENES:SELECTED BIOLOGICAL, METHODICAL AND MEDICAL ASPECTS." Biomedical Papers 153, no. 2 (June 1, 2009): 93–102. http://dx.doi.org/10.5507/bp.2009.016.

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19

Baugh, JA, and SC Donnelly. "Macrophage migration inhibitory factor: a neuroendocrine modulator of chronic inflammation." Journal of Endocrinology 179, no. 1 (October 1, 2003): 15–23. http://dx.doi.org/10.1677/joe.0.1790015.

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The diverse actions of macrophage migration inhibitory factor (MIF) within the immuno-neuroendocrine system are yet to be fully understood, but it is clear that MIF plays a pivotal role in the regulation of both the innate and adaptive immune response. An emerging body of data presently indicates that MIF's position within the cytokine cascade is to act in concert with glucocorticoids to control the 'set point' and magnitude of the immune and inflammatory response. In this article we will review the actions of MIF within the immune system and discuss the overlapping and contrasting aspects of

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Al Hadra, Bushra N. "Some of the Immunogenetics Aspects of Aging." Journal of Biomedical and Clinical Research 14, no. 1 (June 1, 2021): 16–30. http://dx.doi.org/10.2478/jbcr-2021-0003.

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Summary The human life span could be influenced by the combined effect of environment, lifestyle, and genetic factors. Twin and family studies suggest that our genes control up to 25% of the lifespan. The aging immune system undergoes age-associated changes at multiple levels, resulting in a gradual loss of its ability to protect the organism against infections, low vaccine responses, and an increased probability of developing autoimmune diseases and malignancies. The highly polymorphic HLA complex is one of the major gene candidates associated with aging due to its crucial role in developing

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21

Kaye, Paul M. "Molecular aspects of immune response and infectious diseases (Advances in Host Defense Mechanisms, vol. 7)." Parasitology Today 7, no. 7 (January 1991): 187. http://dx.doi.org/10.1016/0169-4758(91)90131-7.

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22

Wumba, R., M. Mandina, Y. Nlandu, J. R. Makulo, A. Tshimpi, P. Mbala, A. Mbangama, P. Kabututu, and J. M. Kayembe. "SARS-CoV-2: Molecular Structure, Pathogenesis, Potential Therapeutic Targets, and Immune Response of the Infected Subject." Interdisciplinary Perspectives on Infectious Diseases 2022 (June 2, 2022): 1–10. http://dx.doi.org/10.1155/2022/7856659.

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Background. The pathogenic mechanisms and immune response of COVID-19 are far from clear. Through a documentary review of literature, the authors describe virological and molecular aspects of SARS-CoV-2, the intimate mechanisms of cell infection, and potential therapeutic targets. They also analyze the characteristics of immune response of the infected subject. Objectives. Objectives of this study are to describe the state of knowledge on virological data, molecular and physiopathogenic mechanisms of SARS-CoV-2, with a view to a better understanding of the therapeutic targets, as well as the i

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23

Buldain, Idoia, Leire Martin-Souto, Aitziber Antoran, Maialen Areitio, Leire Aparicio-Fernandez, Aitor Rementeria, Fernando L. Hernando, and Andoni Ramirez-Garcia. "The Host Immune Response to Scedosporium/Lomentospora." Journal of Fungi 7, no. 2 (January 22, 2021): 75. http://dx.doi.org/10.3390/jof7020075.

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Infections caused by the opportunistic pathogens Scedosporium/Lomentospora are on the rise. This causes problems in the clinic due to the difficulty in diagnosing and treating them. This review collates information published on immune response against these fungi, since an understanding of the mechanisms involved is of great interest in developing more effective strategies against them. Scedosporium/Lomentospora cell wall components, including peptidorhamnomannans (PRMs), α-glucans and glucosylceramides, are important immune response activators following their recognition by TLR2, TLR4 and Dec

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Quirino, Angela, Nadia Marascio, Giorgio Settimo Barreca, Luigia Gallo, Aida Giancotti, Angelo Giuseppe Lamberti, Cinzia Peronace, et al. "SARS-CoV-2: Some Aspects of Molecular Evolution, Cellular Pathogenesis, and Immune System Mechanism Elusion." Applied Sciences 11, no. 24 (December 7, 2021): 11605. http://dx.doi.org/10.3390/app112411605.

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The purpose of this review is to address some of the latest aspects regarding molecular features, pathogenic mechanisms, and immune system response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), based on recent publications in this field from March 2020 to May 2021. Interpretation keys for periodic re-emergence of coronavirus infections and other lethal viral pandemics are suggested. Antibody-dependent enhancement (ADE) and other potential mechanisms of immune system deception are put forward. Therefore, vaccine development must take into account ADE and other unwanted side e

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Ribarac-Stepic, Nevena, Snezana Djurica, Zorica Zakula, Goran Koricanac, and Dragoslav Milosevic. "Molecular basis of glucocorticoid action." Srpski arhiv za celokupno lekarstvo 133, Suppl. 1 (2005): 61–66. http://dx.doi.org/10.2298/sarh05s1061r.

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Glucocorticoid hormones are involved in regulation of cell processes and coordinate physiological response to diverse signals. These hormones, through interaction with specific intracellular receptors, coordinate components of physiological repertoires by activating the expression of gene networks. Thus hormone-receptor complexes may function as key constituent in regulation of specific cell functions as well as in provoking differentiation in already determined cells. Analysis of steroid receptors are important for understanding of molecular details of transcriptional control as well as provi

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Galeas-Pena, Michelle, Nathaniel McLaughlin, and Derek Pociask. "The role of the innate immune system on pulmonary infections." Biological Chemistry 400, no. 4 (April 24, 2019): 443–56. http://dx.doi.org/10.1515/hsz-2018-0304.

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Abstract Inhalation is required for respiration and life in all vertebrates. This process is not without risk, as it potentially exposes the host to environmental pathogens with every breath. This makes the upper respiratory tract one of the most common routes of infection and one of the leading causes of morbidity and mortality in the world. To combat this, the lung relies on the innate immune defenses. In contrast to the adaptive immune system, the innate immune system does not require sensitization, previous exposure or priming to attack foreign particles. In the lung, the innate immune res

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Dolmatov, Igor Yu. "Molecular Aspects of Regeneration Mechanisms in Holothurians." Genes 12, no. 2 (February 10, 2021): 250. http://dx.doi.org/10.3390/genes12020250.

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Holothurians, or sea cucumbers, belong to the phylum Echinodermata. They show good regenerative abilities. The present review provides an analysis of available data on the molecular aspects of regeneration mechanisms in holothurians. The genes and signaling pathways activated during the asexual reproduction and the formation of the anterior and posterior parts of the body, as well as the molecular mechanisms that provide regeneration of the nervous and digestive systems, are considered here. Damage causes a strong stress response, the signs of which are recorded even at late regeneration stage

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Jacobs, Andreas H., and Bertrand Tavitian. "Noninvasive Molecular Imaging of Neuroinflammation." Journal of Cerebral Blood Flow & Metabolism 32, no. 7 (May 2, 2012): 1393–415. http://dx.doi.org/10.1038/jcbfm.2012.53.

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Inflammation is a highly dynamic and complex adaptive process to preserve and restore tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous system (CNS) is now recognized to have a constant interplay with the innate and the adaptive immune systems, where resident microglia and infiltrating immune cells from the periphery have important roles. Common diseases of the CNS, such as stroke, multiple sclerosis (MS), and neurodegeneration, elicit a neuroinflammatory response with the goal to limit the extent of the disease and to support repair and regeneration. How

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Canisso, Igor F., Lorenzo G. T. M. Segabinazzi, and Carleigh E. Fedorka. "Persistent Breeding-Induced Endometritis in Mares—A Multifaceted Challenge: From Clinical Aspects to Immunopathogenesis and Pathobiology." International Journal of Molecular Sciences 21, no. 4 (February 20, 2020): 1432. http://dx.doi.org/10.3390/ijms21041432.

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Post-breeding endometritis (i.e., inflammation/infection of the endometrium), is a physiological reaction taking place in the endometrium of mares within 48 h post-breeding, aimed to clear seminal plasma, excess sperm, microorganisms, and debris from the uterine lumen in preparation for the arrival of an embryo. Mares are classified as susceptible or resistant to persistent breeding-induced endometritis (PBIE) based on their ability to clear this inflammation/infection by 48 h post-breeding. Mares susceptible to PBIE, or those with difficulty clearing infection/inflammation, have a deficient i

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Ramon-Patino, Jorge Luis, Sabine Schmid, Sally Lau, Lesley Seymour, Pierre-Olivier Gaudreau, Janice Juan Ning Li, Penelope Ann Bradbury, and Emiliano Calvo. "iRECIST and atypical patterns of response to immuno-oncology drugs." Journal for ImmunoTherapy of Cancer 10, no. 6 (June 2022): e004849. http://dx.doi.org/10.1136/jitc-2022-004849.

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With the advent of immunotherapy as one of the keystones of the treatment of our patients with cancer, a number of atypical patterns of response to these agents has been identified. These include pseudoprogression, where the tumor initially shows objective growth before decreasing in size, and hyperprogression, hypothesized to be a drug-induced acceleration of the tumor burden. Despite it being >10 years since the first immune-oncology drug was approved, neither the biology behind these paradoxical responses has been well understood, nor their incidence, identification criteria, predictive

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Esteves, Eduardo, Vera M. Mendes, Bruno Manadas, Rafaela Lopes, Liliana Bernardino, Maria José Correia, Marlene Barros, Ana Cristina Esteves, and Nuno Rosa. "COVID-19 Salivary Protein Profile: Unravelling Molecular Aspects of SARS-CoV-2 Infection." Journal of Clinical Medicine 11, no. 19 (September 22, 2022): 5571. http://dx.doi.org/10.3390/jcm11195571.

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COVID-19 is the most impacting global pandemic of all time, with over 600 million infected and 6.5 million deaths worldwide, in addition to an unprecedented economic impact. Despite the many advances in scientific knowledge about the disease, much remains to be clarified about the molecular alterations induced by SARS-CoV-2 infection. In this work, we present a hybrid proteomics and in silico interactomics strategy to establish a COVID-19 salivary protein profile. Data are available via ProteomeXchange with identifier PXD036571. The differential proteome was narrowed down by the Partial Least-

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Zhdanov, Vladimir P. "Spatio-temporal aspects of the interplay of cancer and the immune system." Journal of Biological Physics 45, no. 4 (November 26, 2019): 395–400. http://dx.doi.org/10.1007/s10867-019-09535-3.

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AbstractThe conventional mean-field kinetic models describing the interplay of cancer and the immune system are temporal and predict exponential growth or elimination of the population of tumour cells provided their number is small and their effect on the immune system is negligible. More complex kinetics are associated with non-linear features of the response of the immune system. The generic model presented in this communication takes into account that the rates of the birth and death of tumour cells inside a tumour spheroid can significantly depend on the radial coordinate due to diffusion

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Nakaghi, Andréa Cristina Higa, Rosangela Zacarias Machado, Mirela Tinucci Costa, Marcos Rogério André, and Cristiane Divan Baldani. "Canine ehrlichiosis: clinical, hematological, serological and molecular aspects." Ciência Rural 38, no. 3 (June 2008): 766–70. http://dx.doi.org/10.1590/s0103-84782008000300027.

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The aim of the present study was to compare the direct detection methods of Ehrlichia canis (blood smears and nested PCR), serological tests (Dot-ELISA and Immunofluorescent Antibody Test - IFAT), and demonstrate the most suitable test for the diagnosis of different stages of infection. Blood samples and clinical data were collected from 30 dogs examined at the Veterinary Teaching Hospital, UNESP, Jaboticabal, SP, Brazil. The clinical signs most frequently observed were apathy, anorexia, pale mucous membrane, fever, lymphadenopathy, splenomegaly, hemorrhages and uveitis. Evaluating the humoral

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Bernstein, Kenneth E., Romer A. Gonzalez-Villalobos, Jorge F. Giani, Kandarp Shah, Ellen Bernstein, Tea Janjulia, Yosef Koronyo, et al. "Angiotensin-converting enzyme overexpression in myelocytes enhances the immune response." Biological Chemistry 395, no. 10 (October 1, 2014): 1173–78. http://dx.doi.org/10.1515/hsz-2013-0295.

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Abstract Angiotensin-converting enzyme (ACE) plays an important role in blood pressure control. ACE also has effects on renal function, reproduction, hematopoiesis, and several aspects of the immune response. ACE 10/10 mice overexpress ACE in monocytic cells; macrophages from ACE 10/10 mice demonstrate increased polarization toward a proinflammatory phenotype. As a result, ACE 10/10 mice have a highly effective immune response following challenge with melanoma, bacterial infection, or Alzheimer disease. As shown in ACE 10/10 mice, enhanced monocytic function greatly contributes to the ability

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Andalib, Ali Reza, and Maedeh Radandish. "Immunological and Clinical Aspects of Immune Responses to SARS-CoV-2." Journal of Qazvin University of Medical Sciences 24, no. 6 (February 1, 2020): 592–613. http://dx.doi.org/10.32598/jqums.24.6.10.

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The Coronavirus Disease 2019 (COVID-19) caused by a coronavirus named SARS-CoV-2 from the family Coronaviridae, was first reported in December 2019 in China. The disease have mild or severe symptoms such as fever, chills, cough, shortness of breath, body aches, and gastrointestinal symptoms, followed by severe inflammation, cytokine storm, acute respiratory distress syndrome, and dysfunction of other organs. In this narrative review study, the search was conducted on related studies published during January- October 2020 in Google Scholar, PubMed, Embase, and Scopus databases using the keyword

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Tomela, Katarzyna, Bernadeta Pietrzak, Marcin Schmidt, and Andrzej Mackiewicz. "The Tumor and Host Immune Signature, and the Gut Microbiota as Predictive Biomarkers for Immune Checkpoint Inhibitor Response in Melanoma Patients." Life 10, no. 10 (September 25, 2020): 219. http://dx.doi.org/10.3390/life10100219.

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There are various melanoma treatment strategies that are based on immunological responses, among which immune checkpoint inhibitors (ICI) are relatively novel form. Nowadays, anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and anti-programmed death-1 (PD-1) antibodies represent a standard treatment for metastatic melanoma. Although there are remarkable curative effects in responders to ICI therapy, up to 70% of melanoma patients show resistance to this treatment. This low response rate is caused by innate as well as acquired resistance, and some aspects of treatment resistance are st

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Boštjančič, Emanuela, Željka Večerić-Haler, and Nika Kojc. "The Role of Immune-Related miRNAs in the Pathology of Kidney Transplantation." Biomolecules 11, no. 8 (August 12, 2021): 1198. http://dx.doi.org/10.3390/biom11081198.

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MicroRNAs (miRNAs) are members of the non-coding regulatory RNA family that play pivotal roles in physiological and pathological conditions, including immune response. They are particularly interesting as promising therapeutic targets, prognostic and diagnostic markers due to their easy detection in body fluids and stability. There is accumulating evidence that different miRNAs provide disease-specific signatures in liquid samples of distinct kidney injuries. Using experimental models and human samples, there have been numerous suggestions that immune-related miRNAs are also important contribu

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Benayoun, Bérénice. "SEX-DIMORPHIC REGULATION OF INNATE IMMUNITY DURING AGING." Innovation in Aging 6, Supplement_1 (November 1, 2022): 165. http://dx.doi.org/10.1093/geroni/igac059.657.

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Abstract Aging is accompanied by striking changes in chromatin and gene expression across cell types and species. Yet, how chromatin landscapes change with age and regulate transcription, and how epigenomic changes in turn influence aging in response to external or internal cues, is largely unknown. In addition, accumulating evidence indicates that sex hormones play a key role in driving aspects of cellular and molecular sex-dimorphism. In parallel to sex hormones, karyotypic sex (i.e. XX vs. XY) is also likely to have important impact outside of gonadal sex determination. A key compartment wh

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Aldhamen, Yasser A., Sergey S. Seregin, David P. W. Rastall, Charles F. Aylsworth, Yuliya Pepelyayeva, Christopher J. Busuito, Sarah Godbehere-Roosa, Sungjin Kim, and Andrea Amalfitano. "Endoplasmic Reticulum Aminopeptidase-1 Functions Regulate Key Aspects of the Innate Immune Response." PLoS ONE 8, no. 7 (July 24, 2013): e69539. http://dx.doi.org/10.1371/journal.pone.0069539.

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Martí i Líndez, Adrià-Arnau, and Walter Reith. "Arginine-dependent immune responses." Cellular and Molecular Life Sciences 78, no. 13 (May 26, 2021): 5303–24. http://dx.doi.org/10.1007/s00018-021-03828-4.

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AbstractA growing body of evidence indicates that, over the course of evolution of the immune system, arginine has been selected as a node for the regulation of immune responses. An appropriate supply of arginine has long been associated with the improvement of immune responses. In addition to being a building block for protein synthesis, arginine serves as a substrate for distinct metabolic pathways that profoundly affect immune cell biology; especially macrophage, dendritic cell and T cell immunobiology. Arginine availability, synthesis, and catabolism are highly interrelated aspects of immu

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Ehlting, Christian, Stephanie D. Wolf, and Johannes G. Bode. "Acute-phase protein synthesis: a key feature of innate immune functions of the liver." Biological Chemistry 402, no. 9 (July 29, 2021): 1129–45. http://dx.doi.org/10.1515/hsz-2021-0209.

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Abstract The expression of acute-phase proteins (APP’s) maintains homeostasis and tissue repair, but also represents a central component of the organism’s defense strategy, especially in the context of innate immunity. Accordingly, an inflammatory response is accompanied by significant changes in the serum protein composition, an aspect that is also used diagnostically. As the main site of APP synthesis the liver is constantly exposed to antigens or pathogens via blood flow, but also to systemic inflammatory signals originating either from the splanchnic area or from the circulation. Under bot

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Siracusano, Alessandra, Federica Delunardo, Antonella Teggi, and Elena Ortona. "Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story." Clinical and Developmental Immunology 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/639362.

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The larval stage ofEchinococcus granulosuscauses cystic echinococcosis, a neglected infectious disease that constitutes a major public health problem in developing countries. Despite being under constant barrage by the immune system,E. granulosusmodulates antiparasite immune responses and persists in the human hosts with detectable humoral and cellular responses against the parasite.In vitroandin vivoimmunological approaches, together with molecular biology and immunoproteomic technologies, provided us exciting insights into the mechanisms involved in the initiation ofE. granulosusinfection an

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Donn, RP, and DW Ray. "Macrophage migration inhibitory factor: molecular, cellular and genetic aspects of a key neuroendocrine molecule." Journal of Endocrinology 182, no. 1 (July 1, 2004): 1–9. http://dx.doi.org/10.1677/joe.0.1820001.

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The immunological and neuroendocrine properties of macrophage migration inhibitory factor (MIF) are diverse. In this article we review the known cellular, molecular and genetic properties of MIF that place it as a key regulatory cytokine, acting within both the innate and adaptive immune responses.The unexpected and paradoxical induction of MIF secretion by low concentrations of glucocorticoids is explored. The role of MIF as a locally acting modulator of glucocorticoid sensitivity within foci of inflammation is also discussed. MIF has no homology with any other pro-inflammatory cytokine and u

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Zhang, Wenbao, Hao Wen, Jun Li, Renyong Lin, and Donald P. McManus. "Immunology and Immunodiagnosis of Cystic Echinococcosis: An Update." Clinical and Developmental Immunology 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/101895.

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Cystic echinococcosis (CE) is a cosmopolitan zoonosis caused by the larval cystic stage of the dog tapewormEchinococcus granulosus. This complex multicellular pathogen produces various antigens which modulate the host immune response and promote parasite survival and development. The recent application of modern molecular and immunological approaches has revealed novel insights on the nature of the immune responses generated during the course of a hydatid infection, although many aspects of theEchinococcus-host interplay remain unexplored. This paper summarizes recent developments in our under

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Harding, Benjamin W., and Jonathan J. Ewbank. "An integrated view of innate immune mechanisms in C. elegans." Biochemical Society Transactions 49, no. 5 (October 8, 2021): 2307–17. http://dx.doi.org/10.1042/bst20210399.

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The simple notion ‘infection causes an immune response' is being progressively refined as it becomes clear that immune mechanisms cannot be understood in isolation, but need to be considered in a more global context with other cellular and physiological processes. In part, this reflects the deployment by pathogens of virulence factors that target diverse cellular processes, such as translation or mitochondrial respiration, often with great molecular specificity. It also reflects molecular cross-talk between a broad range of host signalling pathways. Studies with the model animal C. elegans hav

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Warr, Alyson R., Carole J. Kuehl, and Matthew K. Waldor. "Shiga toxin remodels the intestinal epithelial transcriptional response to Enterohemorrhagic Escherichia coli." PLOS Pathogens 17, no. 2 (February 2, 2021): e1009290. http://dx.doi.org/10.1371/journal.ppat.1009290.

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Enterohemorrhagic Escherichia coli (EHEC) is a food-borne pathogen that causes diarrheal disease and the potentially lethal hemolytic uremic syndrome. We used an infant rabbit model of EHEC infection that recapitulates many aspects of human intestinal disease to comprehensively assess colonic transcriptional responses to this pathogen. Cellular compartment-specific RNA-sequencing of intestinal tissue from animals infected with EHEC strains containing or lacking Shiga toxins (Stx) revealed that EHEC infection elicits a robust response that is dramatically shaped by Stx, particularly in epitheli

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Zayats, Romaniya, Zhirong Mou, Atta Yazdanpanah, Wan Koh, Paul Lopez, Jude E. Uzonna, and Thomas Murooka. "Cellular dynamics of immune evasion during Leishmania major infection." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 75.6. http://dx.doi.org/10.4049/jimmunol.204.supp.75.6.

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Abstract Concomitant immunity against intracellular parasites is dictated by the immune response and parasite escape mechanisms that prevent clearance. Infection by Leishmania major generates a strong T cell response, yet parasite clearance is incomplete and leaves a small pool of persistently infected cells. T cell behaviours are augmented by the biochemical and spatial conditions of their immediate environments, and a gap in knowledge is the cellular and molecular mechanisms that prevent complete clearance of pathogen-infected cells in the skin. We combined MP-IVM with a novel T-cell recepto

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Qin, Qingqing, Guangyao Li, Lian Jin, Yu Huang, Yu Wang, Chunhong Wei, Zhihong Xu, Zhirui Yang, Haiyang Wang, and Yi Li. "Auxin response factors (ARFs) differentially regulate rice antiviral immune response against rice dwarf virus." PLOS Pathogens 16, no. 12 (December 2, 2020): e1009118. http://dx.doi.org/10.1371/journal.ppat.1009118.

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There are 25 auxin response factors (ARFs) in the rice genome, which play critical roles in regulating myriad aspects of plant development, but their role (s) in host antiviral immune defense and the underneath mechanism remain largely unknown. By using the rice-rice dwarf virus (RDV) model system, here we report that auxin signaling enhances rice defense against RDV infection. In turn, RDV infection triggers increased auxin biosynthesis and accumulation in rice, and that treatment with exogenous auxin reduces OsIAA10 protein level, thereby unleashing a group of OsIAA10-interacting OsARFs to m

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TAN, Seng-Lai, and Peter J. PARKER. "Emerging and diverse roles of protein kinase C in immune cell signalling." Biochemical Journal 376, no. 3 (December 15, 2003): 545–52. http://dx.doi.org/10.1042/bj20031406.

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Members of the protein kinase C (PKC) family are expressed in many different cell types, where they are known to regulate a wide variety of cellular processes that impact on cell growth and differentiation, cytoskeletal remodelling and gene expression in the response to diverse stimuli. The broad tissue distribution and redundancy of in vitro function have often hampered the identification of definitive roles for each PKC family member. However, recent in vivo studies of PKC isoenzyme-selective knockout and transgenic mice have highlighted distinct functions of individual PKCs in the immune sy

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Khammissa, R. A. G., R. Chandran, A. Masilana, J. Lemmer, and L. Feller. "Adverse Immunologically Mediated Oral Mucosal Reactions to Systemic Medication: Lichenoid Tissue Reaction/Interface Dermatitis-Stomatitis, Autoimmune Vesiculobullous Disease, and IgE-Dependent and Immune Complex Reactions." Journal of Immunology Research 2018 (June 10, 2018): 1–10. http://dx.doi.org/10.1155/2018/7645465.

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Drug-induced hypersensitivity immune reactions are exaggerated immunoinflammatory responses to allergenic components of the medications that occur in genetically susceptible subjects. The type of hypersensitivity immune response generated, whether antibody mediated or T cell mediated, or an immune complex reaction is determined by multiple factors, including the molecular characteristics of the allergen, the route of administration of the medication, the manner of presentation of the allergen by antigen-presenting cells to naïve T cells, the repertoire of the T cell receptors, and the cytokine

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