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Dissertations / Theses on the topic 'Immune System's'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Singh-Jasuja, Harpreet. "The heat shock protein Gp96 the immune system's Swiss army knife /." [S.l. : s.n.], 2002. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10028537.

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2

Vauleon, Elodie. "Implications des gènes immuns et des cellules immunes dans le glioblastome." Thesis, Rennes 1, 2013. http://www.theses.fr/2013REN1B005/document.

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Introduction : Le glioblastome (GBM) est la tumeur cérébrale primitive la plus fréquente et la plus grave de l’adulte. Des études épidémiologiques ont mis en évidence que les antécédents d’allergie sont un facteur protecteur, soulignant le possible impact de l’immunité sur le GBM. Plusieurs études transcriptomiques ont également mis en évidence des signatures immunes plus ou moins associées à la survie. Matériel et méthodes : Pour clarifier ce lien et déterminer quels gènes immuns étaient les plus impliqués dans le GBM, nous avons étudié l’expression de 791 gènes immuns dans des échantillons d

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3

Rider, Mark Sterling. "Effect of Cell-Specific, Music-Mediated Mental Imagery on Secretory Immunoglobulin A (sIgA)." Thesis, University of North Texas, 1988. https://digital.library.unt.edu/ark:/67531/metadc331777/.

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This study was an investigation of the effects of physiologically-oriented mental imagery on immune functioning. College students with normal medical histories were randomly selected to one of three groups. Subjects in Group 1 participated in short educational training on the production of secretory immunoglobulin A. They were then tested on salivary IgA, skin temperature and the Profile of Mood States (POMS) before and after listening to a 17-minute tape of imagery instructions with specially-composed background "entrainment" music, designed to enhance imagery. Subjects in Group 2 (placebo co

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4

Tjandra, Anggraeni S. "Studies on insect immune systems." Thesis, Swansea University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639247.

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Improvements in the purification of <i>Galleria mellonella </i> haemocytes using Percoll gradients are described. This procedure resulted in 95% purity for plasmatocytes, 89% for granular cells and 69% for spherule cells. Using unwashed haemocytes taken directly off the Percoll gradients for making monolayers showed that Ca<SUP>2+</SUP> ion concentration, incubation time and temperature affect the number of cells attaching to the coverslips. The inability of these unwashed cells to undertake phagocytosis is discussed. In contrast, separated and washed haemocytes were highly phagocytic although

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5

Koutsos, Elizabeth Allison. "Carotenoids in avian immune systems /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2002. http://uclibs.org/PID/11984.

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6

Myint, Aye Mu. "Neurochemistry immune systems interaction in depressions." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=6834.

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7

Nowak, Tomasz Jerzy. "Immune buildings: development of eWAR systems." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18427.

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We are living in an increasingly complex world. Threats to human life resulting from chemical attacks, as well as terrorism are real. Consequences of such acts are devastating. The main objectives of an Early Warning and Response System (eWAR) are detection, identification, quantification and neutralization of dangerous chemical agents. The primary goal of this project is to create a system which can prevent the spread of chemical agents via a ventilation system of a public building (e.g., a school, a hospital or a government building). Our approach is realistic. The proposed system should be

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8

SWIATCZAK, BARTLOMIEJ JAROSLAW. "SYSTEMIC FEATURES OF IMMUNE RECOGNITION." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/173418.

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The gut is home to a great number of microbes. The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. Here, we explore whether the decision to respond in a certain way to a microorganism is made by single types of cells and molecules or by the collective activity of various kinds of cells and molecules in a given anatomical compartment. We show here that the distinction between pathogenic and non-pathogenic microbes is

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9

Maree, Charl. "Diagnostic monitoring of dynamic systems using artificial immune systems." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/1780.

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Thesis (MScEng (Process Engineering))--University of Stellenbosch, 2006.<br>The natural immune system is an exceptional pattern recognition system based on memory and learning that is capable of detecting both known and unknown pathogens. Artificial immune systems (AIS) employ some of the functionalities of the natural immune system in detecting change in dynamic process systems. The emerging field of artificial immune systems has enormous potential in the application of fault detection systems in process engineering. This thesis aims to firstly familiarise the reader with the various cu

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10

Mayer, Andreas. "Optimal immune systems : a ressource allocation and information processing view of immune defense." Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEE026/document.

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Les organismes biologiques ont développé divers mécanismes immunitaires afin de se protéger des pathogènes. Nous développons ici des modèles mathématiques de systèmes immunitaires, adaptés de façon optimale aux statistiques des pathogènes. Au delà des détails moléculaires, ces mécanismes immunitaires diffèrent dans la manière d'acquérir, de réguler et de transmettre une protection immunitaire ; différences qui pourraient s'avérer essentielles pour la survie à long terme. Afin d'expliquer la diversité des stratégies qui sont observées, nous comparons l'adaptation à long terme de populations en

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11

Lay, Nicholas Christopher. "Enhancing real-time embedded systems development using artificial immune systems." Thesis, University of York, 2009. http://etheses.whiterose.ac.uk/1419/.

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The Consumer Electronics industry produces a large number of systems which exhibit both real-time and embedded properties (RTES). Frequently problems are encountered during the development of these systems due to a mismatch between the requirements of traditional real-time development techniques and the restrictions imposed on the development process by the retail market. There is therefore a requirement for a method which can be used to enhance the development process and improve the reliability of these systems, yet which does not require the intensive formal analysis often required by estab

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12

AMARAL, JORGE LUIS M. DO. "ARTIFICIAL IMMUNE SYSTEMS APPLIED TO FAULT DETECTION." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2006. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=8236@1.

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UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO<br>Este trabalho investiga métodos de detecção de falhas baseados em sistemas imunológicos artificiais, especificamente aqueles baseados no algoritmo de seleção negativa (NSA) e em outras técnicas de reconhecimento próprio/nãopróprio. Inicialmente, foi proposto um esquema de representação baseado em hiperesferas com centros e raios variáveis e três modelos capazes de gerar detectores, com esta representação, de forma eficiente. O primeiro modelo utiliza algoritmos genéticos onde cada gene do cromossomo contém um índice para um ponto de uma distr

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13

Razali, Sazalinsyah. "Immune systems inspired multi-robot cooperative shepherding." Thesis, Loughborough University, 2014. https://dspace.lboro.ac.uk/2134/16361.

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Certain tasks require multiple robots to cooperate in order to solve them. The main problem with multi-robot systems is that they are inherently complex and usually situated in a dynamic environment. Now, biological immune systems possess a natural distributed control and exhibit real-time adaptivity, properties that are required to solve problems in multi-robot systems. In this thesis, biological immune systems and their response to external elements to maintain an organism's health state are researched. The objective of this research is to propose immune-inspired approaches to cooperation, t

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14

Ismail, Amelia Ritahani. "Immune-inspired self-healing swarm robotic systems." Thesis, University of York, 2011. http://etheses.whiterose.ac.uk/2428/.

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The field of artificial immune system (AIS) is an example of biologically inspired computing that takes its inspiration from various aspects of immunology. Techniques from AIS have been applied in solving many different problems such as classification, optimisation and anomaly detection. However, despite the apparent success of the AIS approach, the unique advantages of AIS over and above other computational intelligence approaches are not clear. In order to address this, AIS practitioners need to carefully consider the application area and design methodologies that they adopt. It has been arg

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15

Lee, Loretta Lok-Yan. "Immune Profiling of Systemic Lupus Erythematosus." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14440.

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Studies in animal models and lupus patients suggest several mechanisms driving the loss of B cell regulation in Systemic Lupus Erythematosus (SLE). The first mechanism involves the overexpression of B cell activating factor and the second is driven by follicular T helper (Tfh) cells. Monocytes have been implicated in the pathogenesis of SLE through recognition of immune complexes containing TLR-binding self-antigens. The overall decrease of NK cells and increase of CD56briCD16- NK cells could further promote immune dysregulation in SLE. Our aim was to determine whether these abnormalities co-e

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16

Timmis, Jonathan Ian. "Artificial immune systems : a novel data analysis technique inspired by the immune network theory." Thesis, University of Kent, 2000. https://kar.kent.ac.uk/21989/.

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This thesis presents a novel data analysis technique inspired by the natural immune system. Immunological metaphors were extracted, simplified and applied to create an effective data analysis technique. This thesis builds on foundations of previous work, extracts salient features of the immune system and creates a principled and effective data analysis technique. Throughout this thesis, a methodical and principled approach was adopted. Previous work, along with background immunology was extensively surveyed. Problems with previous research were identified and principles from immunology were ex

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17

Oliveira, José. "Diversité Génétique des Molécules de Réponse Immunitaire Innée dans les Troubles Bipolaires." Thesis, Paris Est, 2015. http://www.theses.fr/2015PESC0043.

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Les troubles bipolaires (TB) sont des troubles chroniques, multifactoriels et multi-systémiques avec une morbidité, mortalité et fardeau socio-économique très élevée. Mieux comprendre le fond génétique et les facteurs environnementaux déclencheurs permettra d'améliorer le diagnostic et la prise en charge thérapeutique. La dysimmunité semble être parallèle à l'apparition, la progression ainsi qu'au développement de comorbidités psychiatriques et somatiques. L'inflammation chronique et l'activation de la microglie sont des mécanismes liant potentiellement l'infection et le stress pendant l'enfan

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18

Degabriele, Robert, University of Western Sydney, and of Informatics Science and Technology Faculty. "Stress and the immune network." THESIS_FIST_XXX_Degabriele_R.xml, 1999. http://handle.uws.edu.au:8081/1959.7/406.

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The clonal selection/defence paradigm appears unable to reconcile immune function with homeostatic activity whereas organismic homeostasis is central to immune function in the network/autopoiesis paradigm. The aim of this investigation, therefore, was to test the proposition that immune function, that is not clonally driven (central immune system activity), contributes to organismic homeostasis in collaboration with psychoneural responses. In one experiment sheep were confined, either in groups or individually, and the time course of changes in cortisol levels, behaviour and T lymphocyte numbe

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19

Zarges, Christine [Verfasser]. "Theoretical foundations of artificial immune systems / Christine Zarges." Dortmund : Universitätsbibliothek Technische Universität Dortmund, 2011. http://d-nb.info/1018083537/34.

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20

Alghamdi, Akram Saleh A. "Interaction between immune and nervous systems in insects." Thesis, University of Leicester, 2012. http://hdl.handle.net/2381/27682.

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In vertebrates, it has been established that interactions exist between the immune system, the nervous system, and behavior. A comparative examination of these interactions in other animals helps us understand the evolution of this interaction. It may also be possible to develop animal models of important human pathologies, which are due to the interactions between these two systems. In insects an immune-behavioral interactions similar to those seen in vertebrates has been shown to exist. This suggests that this interaction has a highly conserved function. For example, activation of immune res

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21

Qiu, Xueni, and 邱雪妮. "Artificial immune systems for job shop scheduling problems." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49617576.

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Effective process scheduling is very important to the modern manufacturing production. This research addresses a classical scheduling problem — the job shop scheduling problem from the standpoint of both static and dynamic environment. In this study, the job shop scheduling problem (JSSP) is investigated in three aspects: (1) static JSSP that operates under a static scheduling environment with known information about the jobs and machines without unexpected events; (2) semi-dynamic JSSP which is developed based on static JSSP but violating the non-operation disruption assumption due to the pr

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22

Fuller, Jason E. Ph D. Massachusetts Institute of Technology. "Non-viral drug delivery systems for immune modulation." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/43202.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2008.<br>Includes bibliographical references.<br>Biodegradable polymer particles have diverse applications in drug delivery. The main objective of this thesis was to apply these delivery systems to modulating the immune system. We optimized particle formulations for the delivery of three novel immune modulating compounds, small inhibiting RNA, immunostimulatory RNA, and 3-1,6-glucan. Because microparticles formulated from PLGA and Poly(3-amino-ester) have been shown to target and transfect DNA in antigen pre

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23

Gibson, Vivienne Brook Liana Christina. "Developing systems for imaging immune responses in vivo." Thesis, University of Strathclyde, 2010. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=22990.

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The kinetics and dynamics of dendritic cell (DC)-T cell interactions in the lymph node (LN) are thought to be critical in initiating and regulating immune responses in both health and disease. DCs are localised in lymphoid and non-lymphoid tissues and effector and memory T cells continually migrate between both sites. However, the relationship and degree of interaction between the non-lymphoid site of tissue inflammation and the draining lymph node (DLN) remains relatively uncharacterised. This thesis aimed to develop novel in vivo model systems that would allow identifiable antigen specific T

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24

Bondal, Akshata A. "Artificial Immune Systems Applied to Job Shop Scheduling." Ohio University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1204990296.

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25

Davoudani, Despina. "Specknets : a case study for artificial immune systems." Thesis, Edinburgh Napier University, 2012. http://researchrepository.napier.ac.uk/Output/5220.

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26

Wong, Wing-ki Vicky. "An immunity-based distributed multiagent control framework." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37314348.

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27

Jiang, Tianlun T. "Commensal-host Interactions Calibrate Systemic Immune Responsiveness." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1529334295910701.

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28

Vasudevan, Swetha. "Immune Based Event-Incident Model for Intrusion Detection Systems: A Nature Inspired Approach to Secure Computing." [Kent, Ohio] : Kent State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1182821562.

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Thesis (M.S.)--Kent State University, 2007.<br>Title from PDF t.p. (viewed Mar. 19, 2009). Advisor: Michael Rothstein. Keywords: intrusion detection systems, immune system, immune detectors, intrusion detection squad, multi-agent system. Includes bibliographical references (p. 62-66).

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29

Madge, Paul. "Exploring C4-Modified Sialosides in Siglec Affinity and Selectivity." Thesis, Griffith University, 2018. http://hdl.handle.net/10072/379286.

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The family of Sialic-acid-binding ImmunoGlobulin-like LECtins, known as Siglecs, play a vital role in the hematopoietic, immune and nervous systems of many mammals, including humans. These membrane-bound proteins mediate cell to cell adhesion and signalling, and act as regulatory systems for a variety of biological functions. All functional Siglecs bind to sialic acid (Neu5Ac) moieties displayed on the terminus of cell surface glycan structures. Although the Siglec family displays remarkably distinct selectivity for different glyosidic linkages (such as Neu5Ac-α2,6 or Neu5Ac-α2,3) and modifica

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30

Pitchai, Manju Sofia. "Harnessing the immune response to enhance osseointegration." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/418638.

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New understanding of immune system biology has led a paradigm shift in the development of biomaterials away from classically ‘inert’, to ‘immuno-modulatory’ biomaterials that have the potential to stimulate an immune response able to promote constructive and functional tissue remodeling responses as opposed to persistent inflammation and scar tissue formation. This project aims to examine macrophage behavior and in particular integrin expression at the cell–biomaterial interface in vitro, in order to delineate the underlying molecular events occurring during biomaterial-mediated osseous healin

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31

Gasir, Fathi Sidig. "Optimization of fuzzy regression trees using artificial immune systems." Thesis, Manchester Metropolitan University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.574508.

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This thesis presents the development of a novel fuzzy regression tree algorithm known as Elgasir, which is based on the CHAID regression tree algorithm and Takagi-Sugeno fuzzy inference. The Elgasir Algorithm is applied to crisp regression trees to produce fuzzy regression trees in order to soften sharp decision boundaries inherited in crisp trees. Elgasir generates a fuzzy rule base by applying fuzzy techniques to crisp regression trees using Trapezoidal membership functions. Then Takagi-Sugeno fuzzy inference is used to aggregate the final output from the fuzzy implications. A novel optimiza

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32

Al-Enezi, Jamal. "Artificial immune systems based committee machine for classification application." Thesis, Brunel University, 2012. http://bura.brunel.ac.uk/handle/2438/6826.

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A new adaptive learning Artificial Immune System (AIS) based committee machine is developed in this thesis. The new proposed approach efficiently tackles the general problem of clustering high-dimensional data. In addition, it helps on deriving useful decision and results related to other application domains such classification and prediction. Artificial Immune System (AIS) is a branch of computational intelligence field inspired by the biological immune system, and has gained increasing interest among researchers in the development of immune-based models and techniques to solve diverse comple

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33

Britt, Nicholas Mason, Madeleine Kate Miller, Donald B. Ph D. Hoover, and John B. M. D. Schweitzer. "IMMUNODEFICIENT R2G2 MOUSE STRAIN YIELDS SPLEENS WITH UNUSUAL CYTOARCHITECTURE AND SYMPATHETIC INNERVATION." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/205.

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The nervous system and immune system contact one another through two-way communication in order to establish and preserve homeostasis. The sympathetic neurotransmitter norepinephrine has an impact on how the immune system responds by affecting regional blood flow and activation of adrenergic receptors on leukocytes. Former studies showed that immune cells are capable of releasing nerve growth factor allowing for the establishment and continuation of sympathetic nerves in targeted tissues. From this gathered information, it was hypothesized that sympathetic nerves would prove to be less frequen

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34

Meshref, Hossam. "Modeling Autonomous Agents' Behavior Using Neuro-Immune Networks." Diss., Virginia Tech, 2002. http://hdl.handle.net/10919/28473.

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Autonomous robots are expected to interact with their dynamic changing environment. This interactions requires certain level of behavior based Intelligence, which facilitates the dynamic adaptation of the robot behavior accordingly with his surrounding environment. Many researches have been done in biological information processing systems to model the behavior of an autonomous robot. The Artificial Immune System (AIS) provides new paradigm suitable for dynamic problem dealing with unknown environment rather than a static problem. The immune system has some features such as memory, tolerance,

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35

Tsiftsoglou, Stefanos Alex. "Structural and functional studies on human complement factor I." Thesis, University of Oxford, 2005. http://ora.ox.ac.uk/objects/uuid:745ea729-07ae-4c15-be83-bb3bb0db99ff.

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The complement system is considered as the chief recognition and effector component of innate immunity; it is involved in inflammation and enhances the adaptive immune response. Factor I (fI) is a heterodimeric serine protease consisting of a heavy (HC) and a light-catalytic (LC) chain; it circulates in an active form regulating complement by selectively cleaving only C3b or C4b in the presence of a cofactor such as factor H (fH), CR1, MCP or C4bp. The cleavage of C3b occurs through a ternary complex formed between fI, C3b and a cofactor like fH and yields iC3b, a major opsonin. The structural

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36

Degabriele, Robert. "Stress and the immune network." Thesis, Campbelltown, N.S.W. : University of Western Sydney, Macarthur, Faculty of Informatics, Science and Technology, 1999. http://handle.uws.edu.au:8081/1959.7/406.

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The clonal selection/defence paradigm appears unable to reconcile immune function with homeostatic activity whereas organismic homeostasis is central to immune function in the network/autopoiesis paradigm. The aim of this investigation, therefore, was to test the proposition that immune function, that is not clonally driven (central immune system activity), contributes to organismic homeostasis in collaboration with psychoneural responses. In one experiment sheep were confined, either in groups or individually, and the time course of changes in cortisol levels, behaviour and T lymphocyte numbe

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37

Barnfield, Christina Mair. "Manipulation of the immune response by genetic vaccination." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249398.

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Rees, Jane A. "The consequences of social life-histories for bee immune systems." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282519.

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39

Mohd, Azmi Nurulhuda Firdaus. "Artificial immune systems for information filtering : focusing on profile adaptation." Thesis, University of York, 2014. http://etheses.whiterose.ac.uk/6695/.

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The human immune system has characteristics such as self-organisation, robustness and adaptivity that may be useful in the development of adaptive systems. One suitable application area for adaptive systems is Information Filtering (IF). Within the context of IF, learning and adapting user profiles is an important research area. In an individual profile, an IF system has to rely on the ability of the user profile to maintain a satisfactory level of filtering accuracy for as long as it is being used. This thesis explores a possible way to enable Artificial Immune Systems (AIS) to filter informa

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40

Yaqoob, Parveen. "The effects of fatty acids on the composition and functions of lymphocytes." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359567.

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41

Thorpe, Christopher John. "Structural analysis of MHC : peptide interaction." Thesis, Birkbeck (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321649.

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42

Blackford, Jeanette. "A study of the rabbit leucocyte and their role in cell adhesion." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363003.

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Coope, Helen Jane. "Analysis of the regulation of NF#kappa#B by TPL 2 kinase." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249176.

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Alderman, Charles Jason John. "The role of oxidative stress in the regulation of dendritic cell function." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249320.

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Gianacopolos, A. K. "Cytokine regulated neutrophil function." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359012.

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Pazmany, Laszlo. "Structure and function of the HLA class I molecules in antigen presentation." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316621.

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47

Coffey, Marcus Jonathan. "Human neutrophil superoxide generation and pathological oxidative stress." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296015.

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Clay, Karina. "Mechanisms underlying the role of sex hormones in the pathogenesis of rheumatoid arthritis." Thesis, University of Bath, 1993. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358063.

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49

Wong, Wing-ki Vicky, and 黃穎琪. "An immunity-based distributed multiagent control framework." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37314348.

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50

Leonard, Dag. "Cardiovascular Disease and Immune Mechanisms in Systemic Lupus Erythematosus." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-221808.

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Systemic lupus erythematosus (SLE) is an autoimmune, inflammatory disease characterized by autoantibody production and an activated type I interferon system. Cardiovascular disease (CVD) is as a major cause of morbidity and mortality. The aim of this thesis was to identify genetic risk factors for CVD in SLE. The role of T cells in regulation of the interferon-α (IFNα) production by plasmacytoid dendritic cells (pDCs) was also investigated. In paper I, a thicker intima, thinner media and increased intima/media ratio was found in young premenopausal women with SLE compared to healthy control

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