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Journal articles on the topic 'Immune system and lung affections'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Flaviano, Sandoval Maldonado, Cesar Lomelí Omar, Vigil Gerardo, Arredondo Robledo Verónica, Gabriel López Hernandez Juan, and Estela Vargas Rios Silvia. "Correlation of Aggressive Environments and Operative Yielding of Manufacturing workers in an Electronics Industry of Mexicali." Partners Universal International Research Journal (PUIRJ) ISSN: 2583-5602 01, no. 04 (2022): 175–81. https://doi.org/10.5281/zenodo.7512208.

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<em>This investigation was made to evaluate the correlation analysis of the presence of aggressive environments in indoor of an electronics industry installed in the Mexicali city, and its negative effect in low yielding of workers of the manufacturing areas, due to its weakened immune system and lung affections. This originated the generation of respiratory diseases as flu as the most common acute respiratory symptom in some workers, being the principal factor of a decrement of its productivity and quality levels. One of the relevant factors of this serious health symptom is the exposure to p

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Albright, Joseph F., and Robert A. Goldstein. "Airborne Pollutants and the Immune System." Otolaryngology–Head and Neck Surgery 114, no. 2 (1996): 232–38. http://dx.doi.org/10.1016/s0194-59989670173-0.

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The effects of airborne pollutants on the immune system have been most widely studied in the respiratory tract. Entry may occur as a volatile gas (ozone, benzene), as liquid droplets (sulfuric acid, nitrogen dioxide), or as particulate matter (diesel exhaust, aromatic hydrocarbons). The subsequent interaction with the immune system may result in local and systemic responses, and studies have shown examples of disease occurring from both overactive immune responses and immunosuppression. For the most part, airborne pollutants (small molecular weight chemicals) have to be coupled with other subs

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Nascimento, Amanda, Upkar Pandher, Brooke Thompson, David Schneberger, Baljit Singh, and Shelley Kirychuk. "Exploring the Immunomodulatory Potential of Natures Immuno: A Study on Mushroom Formulations in Alleviating LPS-Induced Inflammation." Journal of Immunology 212, no. 1_Supplement (2024): 1066_5569. http://dx.doi.org/10.4049/jimmunol.212.supp.1066.5569.

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Abstract Introduction: Inflammatory diseases, such as pulmonary inflammation, lung cancer, and asthma, pose a significant global economic impact, affecting health and quality of life. Proinflammatory cytokines released by the immune system can be activated by Lipopolysaccharides (LPS), an endotoxin mimicking infection by Gram-negative bacteria. Literature suggests an increased risk of inflammatory diseases in females compared to males. Natures Immuno, a formulation extracted from five commonly used mushrooms (Turkey Tail, Cordyceps, Reishi, Shiitake, and Agaricus), aims to address this issue.

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Synodinou, Kalliopi D., Maroulla D. Nikolaki, Konstantinos Triantafyllou, and Arezina N. Kasti. "Immunomodulatory Effects of Probiotics on COVID-19 Infection by Targeting the Gut–Lung Axis Microbial Cross-Talk." Microorganisms 10, no. 9 (2022): 1764. http://dx.doi.org/10.3390/microorganisms10091764.

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The ecosystem of the human gastrointestinal tract, named gut microbiota, represents the most thoroughly mapped ecosystem. Perturbations on bacterial populations cause dysbiosis, a condition correlated to a wide range of autoimmune, neurological, metabolic, cardiovascular, and respiratory diseases. The lungs have their flora, which are directly related to the gut flora via bidirectional communication allowing the transport of microbial metabolites and toxins produced by intestinal bacteria through the circulation and lymphatic system. This mutual microbial cross-talk communication called the gu

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Saigí, Maria, Oscar Mesía-Carbonell, David A. Barbie, and Raquel Guillamat-Prats. "Unraveling the Intricacies of CD73/Adenosine Signaling: The Pulmonary Immune and Stromal Microenvironment in Lung Cancer." Cancers 15, no. 23 (2023): 5706. http://dx.doi.org/10.3390/cancers15235706.

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CD73 and adenosine have gained prominence in lung cancer research. The NT5E gene encodes CD73, known as an ectonucleotidase, which plays a crucial role within tumor cells, with immune-suppressive properties. Beyond cancer, CD73 exerts an influence on cardiac, neural, and renal functions, affecting cardiac, neural, and renal functions. CD73’s significance lies in its production of extracellular adenosine. It is notably expressed across diverse cell types within the immune and stromal lung microenvironment. CD73 expression amplifies in lung tumors, especially non-small cell lung cancer (NSCLC),

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Chunxi, Li, Liu Haiyue, Lin Yanxia, Pan Jianbing, and Su Jin. "The Gut Microbiota and Respiratory Diseases: New Evidence." Journal of Immunology Research 2020 (July 31, 2020): 1–12. http://dx.doi.org/10.1155/2020/2340670.

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Human body surfaces, such as the skin, intestines, and respiratory and urogenital tracts, are colonized by a large number of microorganisms, including bacteria, fungi, and viruses, with the gut being the most densely and extensively colonized organ. The microbiome plays an essential role in immune system development and tissue homeostasis. Gut microbiota dysbiosis not only modulates the immune responses of the gastrointestinal (GI) tract but also impacts the immunity of distal organs, such as the lung, further affecting lung health and respiratory diseases. Here, we review the recent evidence

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Laamech, Reda, Florian Terrec, Camille Emprou, et al. "Efficacy of Plasmapheresis in Nivolumab-Associated ANCA Glomerulonephritis: A Case Report and Pathophysiology Discussion." Case Reports in Nephrology and Dialysis 11, no. 3 (2021): 376–83. http://dx.doi.org/10.1159/000518304.

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Immune checkpoint inhibitors (ICIs) have revolutionized solid organ and hematologic cancer treatments by improving overall prognoses. However, they can lead to overactivation of the immune system and several immune-related adverse events and sometimes affecting the renal system. Although acute interstitial nephritis is well described, we know little about ICI-associated glomerular injury. Herein, we report an exceptional case of renal ANCA positive-associated vasculitis (AAV) after nivolumab therapy. Three weeks after the last nivolumab injection, the patient presented with proteinuria at 1.73

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Tana, Claudio, Francesco Cinetto, Cesare Mantini, et al. "Sarcoidosis and COVID-19: At the Cross-Road Between Immunopathology and Clinical Manifestation." Biomedicines 10, no. 10 (2022): 2525. http://dx.doi.org/10.3390/biomedicines10102525.

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Coronavirus disease 2019 (COVID-19) has been associated with dysregulation of the immune system featuring inappropriate immune responses, exacerbation of inflammatory responses, and multiple organ dysfunction syndrome in patients with severe disease. Sarcoidosis, also known as Besnier–Boeck–Schaumann disease, is an idiopathic granulomatous multisystem disease characterized by dense epithelioid non-necrotizing lesions with varying degrees of lymphocytic inflammation. These two diseases have similar clinical manifestations and may influence each other at multiple levels, eventually affecting the

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Barnett, James S., Kevin K. Yu, Xavier Rivera Rivera, and Asmeen Bhatt. "Severe Dysphagia With Eosinophilic Esophagitis Pattern of Injury Related to Pembrolizumab Therapy." ACG Case Reports Journal 11, no. 1 (2024): e01252. http://dx.doi.org/10.14309/crj.0000000000001252.

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ABSTRACT While immune checkpoint inhibitor (ICI) therapies are effective treatments for many cancers, ICI therapies are associated with immune-related adverse events. We present a 67-year-old man with non–small cell lung carcinoma, who developed severe dysphagia with biopsies from an esophagogastroduodenoscopy showing histopathology consistent with eosinophilic esophagitis while on ICI maintenance therapy with pembrolizumab. The patient's symptoms worsened despite standard therapy. However, he had complete resolution of dysphagia symptoms once pembrolizumab was discontinued. While immune-relat

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Mosunov, Andrey A. "Studies of altered phagocytic and bactericidal function of neutrophils in patients with post-COVID syndrome, depending on the degree of lung damage detected by computer tomography in acute period of coronavirus infection." Russian Journal of Immunology 28, no. 1 (2024): 57–64. https://doi.org/10.46235/1028-7221-16973-soa.

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By the beginning of May 2023, the epidemic situation regarding COVID-19 was assessed by WHO as favorable, thus enabling to cancel the international emergency state and declare the end of the pandemic on May 5, 2023. Currently, COVID-19 is becoming a seasonal infection. COVID-19 is often accompanied by imbalanced immune response including decreased number of white blood cells and functional changes of immune cells, e.g., affecting activity of neutrophils, including their phagocytic abilities. About 48% of patients who suffered from COVID-19 developed a post-COVID syndrome which is referred to a

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Anderson, Dustin, Grayson Beecher, Nabeela Nathoo, et al. "Proposed diagnostic and treatment paradigm for high-grade neurological complications of immune checkpoint inhibitors." Neuro-Oncology Practice 6, no. 5 (2018): 340–45. http://dx.doi.org/10.1093/nop/npy039.

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Abstract Immune checkpoint inhibitors such as antibodies to cytotoxic lymphocyte-associated protein 4 (ipilimumab) and programmed cell-death 1 (pembrolizumab, nivolumab) molecules have been used in non-small cell lung cancer, metastatic melanoma, and renal-cell carcinoma, among others. With these agents, immune-related adverse events (irAEs) can occur, including those affecting the neurological axis. In this review, high-grade neurological irAEs associated with immune checkpoint inhibitors including cases of Guillain-Barré syndrome (GBS) and myasthenia gravis (MG) are analyzed. Based on curren

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Kähkönen, Tiina E., Mari I. Suominen, Jenni H. E. Mäki-Jouppila, et al. "Human Immune System Increases Breast Cancer-Induced Osteoblastic Bone Growth in a Humanized Mouse Model without Affecting Normal Bone." Journal of Immunology Research 2019 (May 9, 2019): 1–10. http://dx.doi.org/10.1155/2019/4260987.

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Bone metastases are prevalent in many common cancers such as breast, prostate, and lung cancers, and novel therapies for treating bone metastases are needed. Human immune system-engrafted models are used in immuno-oncology (IO) studies for subcutaneous cancer cell or patient-derived xenograft implantations that mimic primary tumor growth. Novel efficacy models for IO compounds on bone metastases need to be established. The study was performed using CIEA NOG (NOG) mice engrafted with human CD34+ hematopoietic stem cells (huNOG) and age-matched immunodeficient NOG mice. Bone phenotyping was perf

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Wang, Meng, Jihua Yang, Shuai Wang, Harjot Gill, and Haiying Cheng. "Immunotherapy and the Tumor Microenvironment in Brain Metastases from Non-Small Cell Lung Cancer: Challenges and Future Directions." Current Oncology 32, no. 3 (2025): 171. https://doi.org/10.3390/curroncol32030171.

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Brain metastases (BMs) are a relatively common and severe complication in advanced non-small cell lung cancer (NSCLC), significantly affecting patient prognosis. Metastatic tumor cells can alter the brain tumor microenvironment (TME) to promote an immunosuppressive state, characterized by reduced infiltration of tumor-infiltrating lymphocytes (TILs), diminished expression of programmed death-ligand 1 (PD-L1), and changes in other proinflammatory factors and immune cell populations. Microglia, the resident macrophages of the brain, play a pivotal role in modulating the central nervous system (C

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Binomar, H. M. R., C. Biggs, C. Yang, A. Amid, D. Schraeder, and O. Guttman. "A227 CTLA-4 DEFICIENCY PRESENTING AS CROHN DISEASE IN A TEENAGE BOY WITH MULTI-SYSTEM INVOLVEMENT : A CASE REPORT." Journal of the Canadian Association of Gastroenterology 6, Supplement_1 (2023): 60–61. http://dx.doi.org/10.1093/jcag/gwac036.227.

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Abstract Background Cytotoxic-T-lymphocyte-antigen-4 is a negative immune regulator. CTLA-4 deficiency can cause a complex immune dysregulation syndrome that may present as inflammatory bowel disease. Purpose Case Description: A 14-year-old male presented with several years of abdominal pain, diarrhea, short stature and poor weight gain. Endocolonoscopy diagnosed Crohn disease, with patchy chronic colitis, an ileal granuloma and active duodenitis with intraepithelial lymphocytosis and villous blunting. MRE showed multiple abnormal small bowel loops. Past history included appendicitis, immune t

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Carbone, Annalucia, Pamela Vitullo, Sante Di Gioia, Stefano Castellani, and Massimo Conese. "A New Frontier in Cystic Fibrosis Pathophysiology: How and When Clock Genes Can Affect the Inflammatory/Immune Response in a Genetic Disease Model." Current Issues in Molecular Biology 46, no. 9 (2024): 10396–410. http://dx.doi.org/10.3390/cimb46090618.

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Cystic fibrosis (CF) is a monogenic syndrome caused by variants in the CF Transmembrane Conductance Regulator (CFTR) gene, affecting various organ and systems, in particular the lung, pancreas, sweat glands, liver, gastrointestinal tract, vas deferens, and vascular system. While for some organs, e.g., the pancreas, a strict genotype-phenotype occurs, others, such as the lung, display a different pathophysiologic outcome in the presence of the same mutational asset, arguing for genetic and environmental modifiers influencing severity and clinical trajectory. CFTR variants trigger a pathophysiol

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Dodi, Giulia, Marina Attanasi, Paola Di Filippo, Sabrina Di Pillo, and Francesco Chiarelli. "Virome in the Lungs: The Role of Anelloviruses in Childhood Respiratory Diseases." Microorganisms 9, no. 7 (2021): 1357. http://dx.doi.org/10.3390/microorganisms9071357.

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More recently, increasing attention has been directed to exploring the function of the global virome in health and disease. Currently, by new molecular techniques, such as metagenomic DNA sequencing, the virome has been better unveiled. By investigating the human lung virome, we could provide novel insights into respiratory diseases. The virome, as a part of the microbiome, is characterized by a constant change in composition related to the type of diet, environment, and our genetic code, and other incalculable factors. The virome plays a substantial role in modulating human immune defenses an

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Belluomini, Lorenzo, Alberto Caldart, Alice Avancini, et al. "Infections and Immunotherapy in Lung Cancer: A Bad Relationship?" International Journal of Molecular Sciences 22, no. 1 (2020): 42. http://dx.doi.org/10.3390/ijms22010042.

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Infectious diseases represent a relevant issue in lung cancer patients. Bacterial and viral infections might influence the patients’ prognosis, both directly affecting the immune system and indirectly impairing the outcome of anticancer treatments, mainly immunotherapy. In this analysis, we aimed to review the current evidence in order to clarify the complex correlation between infections and lung cancer. In detail, we mainly explored the potential impact on immunotherapy outcome/safety of (1) bacterial infections, with a detailed focus on antibiotics; and (2) viral infections, discriminating

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Strumiliene, Edita, Jurgita Urbonienė, Laimute Jurgauskiene, et al. "Long-Term Pulmonary Sequelae and Immunological Markers in Patients Recovering from Severe and Critical COVID-19 Pneumonia: A Comprehensive Follow-Up Study." Medicina 60, no. 12 (2024): 1954. http://dx.doi.org/10.3390/medicina60121954.

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Background and Objectives: Severe and critical COVID-19 pneumonia can lead to long-term complications, especially affecting pulmonary function and immune health. However, the extent and progression of these complications over time are not well understood. This study aimed to assess lung function, radiological changes, and some immune parameters in survivors of severe and critical COVID-19 up to 12 months after hospital discharge. Materials and Methods: This prospective observational cohort study followed 85 adult patients who were hospitalized with severe or critical COVID-19 pneumonia at a te

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Hosakote, Yashoda Madaiah, Kempaiah Rayavara, Yuejin Liang, et al. "Role of HMGB1 in the activation of innate immune responses during SARS-CoV-2 infection." Journal of Immunology 210, no. 1_Supplement (2023): 167.35. http://dx.doi.org/10.4049/jimmunol.210.supp.167.35.

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Abstract The ongoing COVID-19 pandemic caused by SARS-CoV-2 has resulted in overwhelming number of deaths worldwide, affecting all age groups. Due to the emergence and rapid spread of SARS-CoV-2 variants and waning immunity in humans to current vaccines, it is imperative that new treatment modalities must continue to be developed for combating this deadly disease. The molecular mechanisms by which SARS-CoV-2 increases risk of serious respiratory disease is largely unknown but exuberant lung inflammatory and immune responses are key. Understanding of the cascades of events that initiate and sus

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Al-Sharif, Nuha, Mohamad Qaisi, Naomi Kaisar, et al. "Neutrophil Extracellular Traps (NETs) in cancer and beyond." South East European Journal of Immunology 8, CITIM (2025): 036. https://doi.org/10.3889/seejim.2025.6097.

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Neutrophils play a major role in tumor biology. The main effects described by us and others of neutrophils in cancer are directly on tumor cells, or indirectly by affecting the stromal immune system. An exciting relatively novel phenomenon described is the neutrophils' ability to release webs of fibrous decondensed chromatin named neutrophil-extracellular traps (NETs). Originally characterized as a novel antimicrobial mechanism, NETs were later described also in the context of cancer, but the exact effects of NETs on tumor and immune cells, and the importance of NETs production (NETosis) in ca

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Perini, Alessandra, Marti Brucoli, Sophie Acton, and Luigi Ombrato. "Abstract B008: Understanding myeloid and lymphoid cell heterogeneity following radiotherapy and its impact on metastasis development in breast cancer." Clinical Cancer Research 31, no. 2_Supplement (2025): B008. https://doi.org/10.1158/1557-3265.targetedtherap-b008.

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Abstract Breast cancer (BC) is the most frequent malignancy in women worldwide and the gold standard for its treatment currently entails resection of the primary tumor, followed by radiotherapy (RT), chemotherapy and/or immunotherapy. Specifically, adjuvant RT directed at the breast has been successfully employed to improve the risk of local recurrences, but the main obstacle to full remission of most BC patients remains the development of metastasis. RT directed at the primary tumor (pRT) acts via a combination of direct cytotoxicity and immunomodulatory effects on the local tumor microenviro

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Kuusisalo, Saara, Jussi P. Koivunen, and Sanna Iivanainen. "Association of Rare Immune-Related Adverse Events to Survival in Advanced Cancer Patients Treated with Immune Checkpoint Inhibitors: A Real-World Single-Center Cohort Study." Cancers 14, no. 9 (2022): 2276. http://dx.doi.org/10.3390/cancers14092276.

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Immune checkpoint inhibitors (ICIs) are associated with immune-related (ir) adverse events (AEs) resembling autoimmune diseases. In this retrospective cohort study of patients (pts) treated with ICIs at Oulu University Hospital from 2014–2020, we analysed the spectrum of severe irAEs and their prognostic nature, focusing on rare irAEs. Pts (n = 173) with lung cancer (n = 76, 43.9%), melanoma (n = 56, 32.4%), renal and bladder cancers (n = 34, 19.7%), head and neck cancers (n = 4, 2.3%), SCC (n = 2, 1.2%), and CRC (n = 1, 0.6%) receiving single anti-PD-(L)1 (n = 160) or combination (ICI-ICI n =

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Zuo, Zhi Tong, Ya Ma, Yan Sun, Cui Qing Bai, Chun Hua Ling, and Feng Lai Yuan. "The Protective Effects of Helicobacter pylori Infection on Allergic Asthma." International Archives of Allergy and Immunology 182, no. 1 (2020): 53–64. http://dx.doi.org/10.1159/000508330.

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As an ancient Gram-negative bacterium, <i>Helicobacter pylori</i> has settled in human stomach. Eradicating <i>H. pylori</i> increases the morbidities of asthma and other allergic diseases. Therefore, <i>H. pylori</i> might play a protective role against asthma. The “disappearing microbiota” hypothesis suggests that the absence of certain types of the ancestral microbiota could change the development of immunology, metabolism, and cognitive ability in our early life, contributing to the development of some diseases. And the Hygiene Hypothesis links early env

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Wang, Xueqian, Fafeng Cheng, Wenxiang Zhu, et al. "Majie Pingchuan Cataplasm Regulates Thymic Stromal Lymphopoietin in Rats with Asthma." Journal of Immunology 198, no. 1_Supplement (2017): 55.32. http://dx.doi.org/10.4049/jimmunol.198.supp.55.32.

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Abstract As a new type of external preparations, cataplasm is widely used in clinical practice. In this study, we aimed to explore the efficacy and mechanism of Majie Pingchuan Cataplasm (MJPC) on asthma. By treating the brown-norway asthmatic rats with MJPC, it was found that the incubation period was significantly longer compared with rats injected with dexamethasone (P&lt;0.05); in addition, the airway smooth muscle spasm was relieved compared with the asthmatic rats (P&lt;0.05); it was observed that the number of inflammatory cells (such as eosinophils and neutrophils) was reduced

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Zanotti, Giorgio, Monica Casiraghi, John B. Abano, et al. "Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema." American Journal of Physiology-Lung Cellular and Molecular Physiology 297, no. 1 (2009): L52—L63. http://dx.doi.org/10.1152/ajplung.90406.2008.

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Toll-like receptors (TLRs) of the innate immune system contribute to noninfectious inflammatory processes. We employed a murine model of hilar clamping (1 h) with reperfusion times between 15 min and 3 h in TLR4-sufficient (C3H/OuJ) and TLR4-deficient (C3H/HeJ) anesthetized mice with additional studies in chimeric and myeloid differentiation factor 88 (MyD88)- and TLR4-deficient mice to determine the role of TLR4 in lung ischemia-reperfusion injury. Human pulmonary microvascular endothelial monolayers were subjected to simulated warm ischemia and reperfusion with and without CRX-526, a competi

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Smith, Issar. "Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence." Clinical Microbiology Reviews 16, no. 3 (2003): 463–96. http://dx.doi.org/10.1128/cmr.16.3.463-496.2003.

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SUMMARY Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major causes of mortality, since two million people die each year from this malady. TB has many manifestations, affecting bone, the central nervous system, and many other organ systems, but it is primarily a pulmonary disease that is initiated by the deposition of Mycobacterium tuberculosis, contained in aerosol droplets, onto lung alveolar surfaces. From this point, the progression of the disease can have several outcomes, determined largely by the response of the host immune system. The efficacy of this

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Suárez-Martínez, Clara, Marina Santaella-Pascual, Genoveva Yagüe-Guirao, Luis García-Marcos, Gaspar Ros, and Carmen Martínez-Graciá. "The Early Appearance of Asthma and Its Relationship with Gut Microbiota: A Narrative Review." Microorganisms 12, no. 7 (2024): 1471. http://dx.doi.org/10.3390/microorganisms12071471.

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Asthma is, worldwide, the most frequent non-communicable disease affecting both children and adults, with high morbidity and relatively low mortality, compared to other chronic diseases. In recent decades, the prevalence of asthma has increased in the pediatric population, and, in general, the risk of developing asthma and asthma-like symptoms is higher in children during the first years of life. The “gut–lung axis” concept explains how the gut microbiota influences lung immune function, acting both directly, by stimulating the innate immune system, and indirectly, through the metabolites it g

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Kronenberg, Mitchell, Jr-Wen Shui, Daisuke Takahashi, et al. "HVEM is a TNF family receptor that is a crucial regulator of epithelial and lymphocyte responses in the mucosal immune system (P3192)." Journal of Immunology 190, no. 1_Supplement (2013): 124.7. http://dx.doi.org/10.4049/jimmunol.190.supp.124.7.

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Abstract HVEM is a TNF super family receptor, and previously we showed that epithelial HVEM is required for innate immune responses to pathogenic bacteria in the intestine and lung, and that it acts by enhancing epithelial Stat3 activation (Nature 488:222, 2012). Now, we show that HVEM is also an important regulator of lymphoid cells in the mucosal immune response. IL-17 and IL-22 are protective cytokines after oral infection with Citrobacter rodentium. Mice deficient for HVEM have a reduced IL-22 response by innate lymphoid cells (ILC) in the colon lamina propria at early times after infectio

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Boruah, Abhilasha Pankaj, Kathryn Demski, Pradnya Dinkar Patil, Cassandra Calabrese, and Pauline Funchain. "Implementation and impact of a novel multidisciplinary immune-related adverse events tumor board for patients receiving immune checkpoint inhibitor therapy." Journal of Clinical Oncology 39, no. 15_suppl (2021): e13541-e13541. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e13541.

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e13541 Background: Given the often atypical and diverse presentations of immune-related adverse events, the utilization of an institutional multidisciplinary irAE tumor board is an effective strategy to deliver comprehensive, collaborative, and efficient care to patients experiencing these effects. We report the clinical impact of a multidisciplinary tumor board dedicated towards management of irAEs in patients receiving checkpoint inhibitor therapy. Methods: We completed a retrospective review of patients discussed during our multidisciplinary irAE tumor board at Cleveland Clinic Taussig Canc

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Kobayashi, Takayuki, Makiko Yomota, Masachika Ikegami, et al. "MO31-3 Association between tumor mutation burden and oncogenic mutation affecting the immune system of patients with non-small cell lung cancer." Annals of Oncology 34 (November 2023): S1416. http://dx.doi.org/10.1016/j.annonc.2023.09.233.

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Maessen, Lenn, Leonoor S. Boers, Jannes Heylen, et al. "Viral reactivations and fungal infections in nonresolving acute respiratory distress syndrome." European Respiratory Review 34, no. 175 (2025): 240153. https://doi.org/10.1183/16000617.0153-2024.

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Acute respiratory distress syndrome (ARDS) is a condition affecting 10% of patients requiring admission to the intensive care unit and results from endothelial dysfunction, alveolar epithelial injury and unbalanced inflammation, leading to exudative pulmonary oedema. A significant portion of these patients experience a lung injury that fails to resolve. Persistent or worsening respiratory failure beyond 5 days after the initiation of mechanical ventilation is referred to as nonresolving ARDS. Viral and fungal pathogens can exploit the hyperinflammatory environment and altered immune landscape

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Yamagami, Takashi, Evan Colletti, Heinz Wiendl, Esmail Zanjani, Christopher D. Porada, and Graca Almeida-Porada. "Expression of Molecules Involved in Fetal-Maternal Tolerance Allows Human Mesenchymal Stem Cells to Engraft at High Levels across Immunologic Barriers." Blood 112, no. 11 (2008): 3480. http://dx.doi.org/10.1182/blood.v112.11.3480.3480.

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Abstract The ability of HLA-G to inhibit NK cells, cytotoxic T cells, and the maturation of dendritic cells is thought to play a crucial role in the maintenance of fetomaternal tolerance during pregnancy. Recent studies have provided evidence that MSC are not as immuno-inert as once thought, since they are capable of expressing HLA-II if stimulated by IFN-γ and of activating and serve as targets of NK-mediated lysis. Here we investigated whether transducing human MSC with a retroviral vector encoding HLA-G1 (MSC-G1) or G5 (MSC-G5) would render these cells and their differentiated progeny undet

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Lei, Fengyang, Naiwen Cui, Chengxin Zhou, James Chodosh, Demetrios G. Vavvas, and Eleftherios I. Paschalis. "CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages." Proceedings of the National Academy of Sciences 117, no. 38 (2020): 23336–38. http://dx.doi.org/10.1073/pnas.1922788117.

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Colony-stimulating factor 1 receptor (CSF1R) inhibition has been proposed as a method for microglia depletion, with the assumption that it does not affect peripheral immune cells. Here, we show that CSF1R inhibition by PLX5622 indeed affects the myeloid and lymphoid compartments, causes long-term changes in bone marrow-derived macrophages by suppressing interleukin 1β, CD68, and phagocytosis but not CD208, following exposure to endotoxin, and also reduces the population of resident and interstitial macrophages of peritoneum, lung, and liver but not spleen. Thus, small-molecule CSF1R inhibition

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Villeret, Bérengère, Reem Ghinnagow, Saadé Kheir, et al. "Pseudomonas Aeruginosa Lung Infection Subverts Lymphocytic Responses through IL-23 and IL-22 Post-Transcriptional Regulation." International Journal of Molecular Sciences 23, no. 15 (2022): 8427. http://dx.doi.org/10.3390/ijms23158427.

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Pseudomonas aeruginosa (P.a) is a pathogen causing significant morbidity and mortality, particularly in hospital patients undergoing ventilation and in individuals with cystic fibrosis. Although we and others have investigated mechanisms used by P.a to subvert innate immunity, relatively less is known about the potential strategies used by this bacterium to fight the adaptive immune system and, in particular, T cells. Here, using RAG KO (devoid of ‘classical’ αβ and γδ TCR T lymphocytes) and double RAG γC KO mice (devoid of T, NK and ILC cells), we demonstrate that the lymphocytic compartment

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Mormile, Ilaria, Gerardo Nazzaro, Marco Filippelli, et al. "Pulmonary Involvement in Systemic Lupus Erythematosus: A Potentially Overlooked Condition." Biomedicines 13, no. 6 (2025): 1485. https://doi.org/10.3390/biomedicines13061485.

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Systemic lupus erythematosus (SLE) is a pleiotropic disease that can present in numerous forms, ranging from mild mucocutaneous symptoms to severe manifestations affecting multiple organs. SLE has the potential to impact any segment of the respiratory system, exhibiting a range of severity levels throughout the different stages of the disease. Pulmonary manifestations in SLE patients can be classified as primary (i.e., directly related to SLE and to immune-mediated damage), secondary to other SLE manifestations (e.g., nephrotic syndrome, renal failure, congestive heart failure), and comorbidit

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Wang, Hongchao, Yuhao Zhao, Zhangming Pei, et al. "Effect of Mixed Probiotics on Alleviating H1N1 Influenza Infection and Regulating Gut Microbiota." Foods 13, no. 19 (2024): 3079. http://dx.doi.org/10.3390/foods13193079.

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Influenza and other respiratory infections cause annual epidemics worldwide, with high incidence and mortality rates reported among immunocompromised infants and elderly individuals. Probiotics can modulate the immune system through their bacterial compositions and metabolites, affecting influenza infections and effectively responding to viral mutations. Therefore, we evaluated the anti-influenza effects of mixed probiotics administered orally before and after influenza infection. The results showed that the mixed probiotics consisting of Lacticaseibacillus rhamnosus CCFM1279, Limosilactobacil

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Calabretta, Raffaella, Lucian Beer, Helmut Prosch, et al. "Induction of Arterial Inflammation by Immune Checkpoint Inhibitor Therapy in Lung Cancer Patients as Measured by 2-[18F]FDG Positron Emission Tomography/Computed Tomography Depends on Pre-Existing Vascular Inflammation." Life 14, no. 1 (2024): 146. http://dx.doi.org/10.3390/life14010146.

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Background: Immune checkpoint inhibitors (ICI) are one of the most effective therapies in oncology, albeit associated with various immune-related adverse events also affecting the cardiovascular system. Methods: We aimed to investigate the effect of ICI on arterial 2-[18F]FDG uptake by using 2-[18F]FDG PET/CT imaging pre/post treatment in 47 patients with lung cancer. Maximum 2-[18F]FDG standardized uptake values (SUVmax) and target-to-background ratios (TBRs) were calculated along six arterial segments. We classified the arterial PET lesions by pre-existing active inflammation (cut-off: TBRpr

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Koether, V., A. Dupont, J. Labreuche, et al. "AB0401 CAN DUAL-ENERGY CT LUNG PERFUSION DETECT ABNORMALITIES AT THE LEVEL OF LUNG CIRCULATION IN SYSTEMIC SCLEROSIS (SSC)? PRELIMINARY EXPERIENCE IN 101 PATIENTS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1229.1–1229. http://dx.doi.org/10.1136/annrheumdis-2021-eular.69.

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Background:Systemic sclerosis (SSc) is an autoimmune disorder that is characterized by a interplay of vascular abnormalities, immune system activation and an uncontrolled fibrotic response associated with interstitial lung disease affecting about 40% of patients. Identification of ILD relies on high-resolution CT that identify features suggestive of the histologic patterns of SSc(1). CT is used to determine pattern and extent of ILD and participates in the prediction of ILD progression(2).All group of pulmonary hypertension (PH) may occur with an overall prevalence reported in up to one fifth

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D’Ambrosi, Nadia, Martina Milani, and Savina Apolloni. "S100A4 in the Physiology and Pathology of the Central and Peripheral Nervous System." Cells 10, no. 4 (2021): 798. http://dx.doi.org/10.3390/cells10040798.

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S100A4 is a member of the large family of S100 proteins, exerting a broad range of intracellular and extracellular functions that vary upon different cellular contexts. While S100A4 has long been implicated mainly in tumorigenesis and metastatization, mounting evidence shows that S100A4 is a key player in promoting pro-inflammatory phenotypes and organ pro-fibrotic pathways in the liver, kidney, lung, heart, tendons, and synovial tissues. Regarding the nervous system, there is still limited information concerning S100A4 presence and function. It was observed that S100A4 exerts physiological ro

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Souza, Vanessa G. P., Aisling Forder, Nikita Telkar, et al. "Identifying New Contributors to Brain Metastasis in Lung Adenocarcinoma: A Transcriptomic Meta-Analysis." Cancers 15, no. 18 (2023): 4526. http://dx.doi.org/10.3390/cancers15184526.

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Lung tumors frequently metastasize to the brain. Brain metastasis (BM) is common in advanced cases, and a major cause of patient morbidity and mortality. The precise molecular mechanisms governing BM are still unclear, in part attributed to the rarity of BM specimens. In this work, we compile a unique transcriptomic dataset encompassing RNA-seq, microarray, and single-cell analyses from BM samples obtained from patients with lung adenocarcinoma (LUAD). By integrating this comprehensive dataset, we aimed to enhance understanding of the molecular landscape of BM, thereby facilitating the identif

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Furman, E. G., M. N. Repetskaya, and I. P. Koryukina. "Lower airways and lungs affection in coronavirus infection covid-19 among children and adults: similarities and differences (review of literature)." Perm Medical Journal 37, no. 2 (2020): 5–14. http://dx.doi.org/10.17816/pmj3725-14.

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The review presents the data of actual publications for 2019-2020 regarding the course of a new coronavirus infection COVID-19 in children and adults. The features of a new coronavirus SARS-CoV-2, the causes of its tropism to human respiratory system are discussed. The questions of clinical and roentgenological manifestations of lung affection in COVID-19 among children and adults are described in details. The adult COVID-19 is characterized by the presence of clinical symptoms of acute respiratory viral infection: elevation of temperature ( 90 %), cough (dry or with small amount of sputum) in

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de Carvalho Patricio, Beatriz Ferreira, Juliana Oliveira da Silva Lopes Pereira, Michelle Alvares Sarcinelli, Bianca Portugal Tavares de Moraes, Helvécio Vinicius Antunes Rocha, and Cassiano Felippe Gonçalves-de-Albuquerque. "Could the Lung Be a Gateway for Amphotericin B to Attack the Army of Fungi?" Pharmaceutics 14, no. 12 (2022): 2707. http://dx.doi.org/10.3390/pharmaceutics14122707.

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Fungal diseases are a significant cause of morbidity and mortality worldwide, primarily affecting immunocompromised patients. Aspergillus, Pneumocystis, and Cryptococcus are opportunistic fungi and may cause severe lung disease. They can develop mechanisms to evade the host immune system and colonize or cause lung disease. Current fungal infection treatments constitute a few classes of antifungal drugs with significant fungi resistance development. Amphotericin B (AmB) has a broad-spectrum antifungal effect with a low incidence of resistance. However, AmB is a highly lipophilic antifungal with

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Kumar, Dhiraj, Sreeharsha Gurrapu, Hyunho Han, et al. "750 Malat1 lncRNA controls metastatic reactivation of dormant breast cancer by immune evasion." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A799. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0750.

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BackgroundLong non-coding RNAs (lncRNAs) are involved in various biological processes and diseases. Malat1 (metastasis-associated lung adenocarcinoma transcript 1), also known as Neat2, is one of the most abundant and highly conserved nuclear lncRNAs. Several studies have shown that the expression of lncRNA Malat1 is associated with metastasis and serving as a predictive marker for various tumor progression. Metastatic relapse often develops years after primary tumor removal as a result of disseminated tumor cells undergoing a period of latency in the target organ.1–4 However, the correlation

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Kamperman, Renske G., Anneke J. van der Kooi, Marianne de Visser, Eleonora Aronica, and Joost Raaphorst. "Pathophysiological Mechanisms and Treatment of Dermatomyositis and Immune Mediated Necrotizing Myopathies: A Focused Review." International Journal of Molecular Sciences 23, no. 8 (2022): 4301. http://dx.doi.org/10.3390/ijms23084301.

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Idiopathic inflammatory myopathies (IIM), collectively known as myositis, are a composite group of rare autoimmune diseases affecting mostly skeletal muscle, although other organs or tissues may also be involved. The main clinical feature of myositis is subacute, progressive, symmetrical muscle weakness in the proximal arms and legs, whereas subtypes of myositis may also present with extramuscular features, such as skin involvement, arthritis or interstitial lung disease (ILD). Established subgroups of IIM include dermatomyositis (DM), immune-mediated necrotizing myopathy (IMNM), anti-syntheta

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Brihn, Lesil, Cassandra Calabrese, Keren Zhou, et al. "Abstract A096: Impact of a multidisciplinary immune-related adverse event (irAE) tumor board in patients (pts) receiving immune checkpoint inhibitors (ICI)." Cancer Immunology Research 13, no. 2_Supplement (2025): A096. https://doi.org/10.1158/2326-6074.io2025-a096.

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Abstract Background: IrAEs are common complications of ICI therapy and can have diverse manifestations, affecting nearly any organ system and often requiring multi-disciplinary care. An institutional irAE tumor board is an effective tool to facilitate multidisciplinary collaboration and expedite care of these pts. We report the clinical application of our institutional irAE tumor board. Methods: We performed a retrospective review of pts discussed at our multidisciplinary irAE tumor board at Cleveland Clinic Taussig Cancer Center since establishment of irAE tumor board in 2017. The irAE tumor

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Wallis, Deeann, Christian Fay, Kelley Bradley, et al. "Abstract P3-08-01: Loss of NF1 drives hormone dependent mammary carcinogenesis in a rat model with intact immune system." Cancer Research 83, no. 5_Supplement (2023): P3–08–01—P3–08–01. http://dx.doi.org/10.1158/1538-7445.sabcs22-p3-08-01.

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Abstract Loss of NF1 plays a major role as an oncogenic driver in many cancer types and can be found in up to 33% of all breast cancers (BC). Loss of NF1 is also a prognostic indicator for increased cancer risk at an earlier age, poorer outcomes, and therapeutic resistance. In addition, certain NF1 genotypes may increase cancer risks, while others do not. NF1 is largely perceived as a classic Ras-opathy syndrome due to inactivating mutations in neurofibromin affecting RAS-MAPK signaling. However, recently it has been shown that NF1 binds estrogen receptor alpha (ER) and acts as a transcription

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Fantini, Massimo Claudio, Agnese Favale, Sara Onali, and Federica Facciotti. "Tumor Infiltrating Regulatory T Cells in Sporadic and Colitis-Associated Colorectal Cancer: The Red Little Riding Hood and the Wolf." International Journal of Molecular Sciences 21, no. 18 (2020): 6744. http://dx.doi.org/10.3390/ijms21186744.

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Regulatory T cells represent a class of specialized T lymphocytes that suppress unwanted immune responses and size the activation of the immune system whereby limiting collateral damages in tissues involved by inflammation. In cancer, the accumulation of Tregs is generally associated with poor prognosis. Many lines of evidence indicate that Tregs accumulation in the tumor microenvironment (TME) suppresses the immune response against tumor-associated antigens (TAA), thus promoting tumor progression in non-small cell lung carcinoma (NSLC), breast carcinoma and melanoma. In colorectal cancer (CRC

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Milota, Tomas, Jitka Smetanova, and Jirina Bartunkova. "Clinical Outcome of Coronavirus Disease 2019 in Patients with Primary Antibody Deficiencies." Pathogens 12, no. 1 (2023): 109. http://dx.doi.org/10.3390/pathogens12010109.

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In 2019, the novel coronavirus, SARS-CoV-2, caused a worldwide pandemic, affecting more than 630 million individuals and causing 6.5 million deaths. In the general population, poorer outcomes have been associated with older age, chronic lung and cardiovascular diseases, and lymphopenia, highlighting the important role of cellular immunity in the immune response against SARS-CoV-2. Moreover, SARS-CoV-2 variants may have a significant impact on disease severity. There is a significant overlap with complications commonly found in inborn errors of immunity (IEI), such as primary antibody deficienc

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Kerna, Nicholas A., ND Victor Carsrud Carsrud, Xuan Zhao, et al. "The Pathophysiology of Scoliosis Across the Spectrum of Human Physiological Systems." European Journal of Medical and Health Research 2, no. 2 (2024): 69–81. https://doi.org/10.59324/ejmhr.2024.2(2).07.

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Scoliosis is a medical condition characterized by an abnormal lateral curvature of the spine. It can lead to various health issues, affecting mobility, respiratory function, and overall quality of life. There are several types of scoliosis, including idiopathic, congenital, neuromuscular, degenerative, and functional. The severity of scoliosis is measured by the degree of spinal curvature, typically expressed in degrees through a system known as the Cobb angle. Early detection and intervention are fundamental in managing scoliosis, as more severe forms may necessitate bracing or surgical inter

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Dahal, Tshetiz, Dhiraj Prasad Shah, and Aman Kumar Yadav. "Lymphocytopenia repercussions on stage III Non-small cell lung cancer (NSCLC) patients\' tumour progression and their clinical results after chemoradiation." IP Indian Journal of Anatomy and Surgery of Head, Neck and Brain 9, no. 2 (2023): 44–50. http://dx.doi.org/10.18231/j.ijashnb.2023.010.

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According to earlier research, tumour response, Lymphocytopenia, and a system-wide immune-inflammatory indexes all affect the clinical results of Stage III NSCLC. We postulated that the tumour response to CRT would be related to hematologic parameters and could perhaps anticipate clinical results.Retrospective evaluation of stage III NSCLC patients treated at a single facility between 2015 and 2020 was done. After receiving CRT, the pre-treatment gross tumour volume (GTV) was measured again. Full blood counts were taken before, during, and after treatment. Neutrophil platelet lymphocyte was us

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