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Dissertations / Theses on the topic 'Immunity (Immunology)'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 September 2023

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1

Tjärnlund, Anna. "Mucosal Immunity in Mycobacterial infections." Doctoral thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6782.

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<p>More than a century after the identification of the tubercle bacillus and the first attempts at vaccination, tuberculosis (TB) still remains one of the world’s most serious infectious diseases. TB, caused by the bacterium <i>Mycobacterium tuberculosis</i>, is typically a disease of the lung, which serves both as port of entry and as the major site of disease manifestation. The currently used vaccine, BCG, is administered parenterally and induces a systemic immune response. However, it fails to protect against pulmonary TB, thereby raising the question whether vaccination targeting the mucos
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2

Israelsson, Elisabeth. "The role of antibody mediated parasite neutralization in protective immunity against malaria." Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7137.

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3

Sheu, Eric G. "Immunology of T cell vaccines." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288552.

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4

Rahman, Muhammad Jubayer. "Mucosal immunity against mycobacterial infection." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-39170.

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This thesis aimed to the identification of immune biomarkers of mycobacterial infection for better diagnosis of tuberculosis (TB) and also focused on new vaccination strategies with a particular emphasis on the immune responses in the respiratory tract using murine models. Since the lung is the natural habitat for the M. tuberculosis, we reasoned that immune responses detected locally in the lungs would be good correlates of infection (Paper I). Likewise, immune responses induced in the respiratory tract following immunization would be more effective against mycobacterial infection. We showed
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5

Tubau, Juni Nuria. "Characterization of Regulatory Mechanisms in Mucosal Immunity by Systems Immunology." Diss., Virginia Tech, 2020. http://hdl.handle.net/10919/104250.

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The mucosal immunity of the gastrointestinal (GI) tract is constituted by a complex, highly specialized and dynamic system of immune components that aim to protect the gut from external threats. The sustained exposure of the mucosal immune system of the GI tract to an enormous number of lumen antigens, requires the constant upkeep of a highly regulated balance between initiation of immune responses against harmful agents and the generation of immune tolerance towards innocuous antigens. Therefore, the regulatory component is key to preserve tissue homeostasis and a normal functioning of the sy
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6

Clever, David C. Clever. "T Cell-Intrinsic PHD Proteins Regulate Pulmonary Immunity." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1471868519.

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7

Wuttge, Dirk Marcus. "Cellular immunity and inflammation in atherosclerosis /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-051-2/.

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8

Haghayeghi, Amirhossein. "Pellino function in «Drosophila» innate immunity." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86930.

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The Toll pathway mediates innate immunity, the first line of defense against pathogens in vertebrates and invertebrates. In Drosophila the Toll pathway protects against Gram-positive bacteria and fungi by inducing antimicrobial peptides such as Drosomycin. Pellino is a highly conserved protein which biochemically interacts with Pelle/IRAK, a crucial kinase downstream of Toll. Here we report that the chemically induced Pellino 7T2 mutant does not affect Toll pathway function in early embryonic dorsoventral patterning, but it severely compromises induction of Drosomycin upon infection with Gram
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9

Joel, Katie D. "Demobilizing immunology : autopoiesis and autonomy in Francisco Varela's theory of immunity." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43118.

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This thesis examines the transformative impact of the immune network theory on theoretical immunology, especially how immunity has been understood and described metaphorically in the scholarship. The immune system had been conventionally couched in warfare rhetoric. At the end of the nineteenth century, Russian scientist and pathologist Elie Metchnikoff depicted pathogens as savages in the theory of phagocytosis, which, he postulated, the body must destroy with equal ferocity. Virologist Frank Burnet further affirmed this concept in 1957. In the Clonal Selection Theory, he articulated the mode
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10

Arnaout, Ramy A. "Mathematical models of antiviral immunity." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325989.

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11

Makedonas, George. "Cellular immunity among HIV exposed, uninfected individuals." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111828.

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Two models of HIV infection have been studied extensively with the goal of identifying immune correlate(s) of protection against HIV: (1) the simian immunodeficiency virus (SIV) infection of rhesus macaque monkeys and (2) individuals with repeated exposure to HIV who remain uninfected by the virus (EUs). Both paradigms suggest that T cell-mediated immunity plays an important role in controlling HIV replication. Evidence from the SIV/macaque system, however, predicts that HIV vaccines aimed at eliciting T cell responses will fail to induce sterilizing immunity against HIV. The aim of the work p
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12

Awah, Nancy. "Studies on Plasmodium falciparum asexual blood stage antigens : RAP-2/RSP-2 and Pf332 in focus." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-57255.

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The life cycle of the malaria parasite is very complex and provides a number of potential targets for vaccination. In this thesis, data on two plasmodial asexual blood stage antigens (RAP-2 and Pf332) are presented. A partial aim of the work presented herein was to investigate the mechanisms responsible for the destruction of erythroid cells in anaemia, and more specifically to define the role of the rhoptry associated protein (RAP)-2 and other members of the RAP complex, RAP-1 and -3 in processes resulting in anaemia. Antibodies to the RAP complex were shown to have the potential to mediate t
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13

Hammarström, Viera. "B-cell immunity in patients with hematological malignancies and after stem cell transplantation : studies with special reference to tetanus and pneumococcal immunity /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980828hamm.

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14

Ing, Rebecca Yat Loo 1971. "Mechanisms of innate immunity to blood-stage malaria infection : role of dendritic cells in host-parasite interactions and induction of protective immunity." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102510.

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A favorable outcome of blood-stage malaria infection requires immune responses that effectively eliminate the infection with minimum pathology to the host. There is strong evidence that the innate immune system is critical for initiating and shaping the subsequent adaptive immune response to blood-stage Plasmodium parasites. As sentinels of infection and potent activators of immunity, dendritic cells (DCs) are pivotally positioned to control the immune response to malaria and thereby influence the outcome of infection. Experiments performed in this thesis work aimed to determine the role of DC
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15

Li, Jennifer. "Targeting innate immunity in acute kidney injury." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29872.

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Acute kidney injury (AKI) is an umbrella term for various aetiological insults, disrupting the kidneys’ capacity to carry out many of its essential physiological function. We focused on the ischemia reperfusion injury (IRI) model of AKI, which is applicable across native and transplant kidney AKI. The current standard of care for patients with acute kidney injury (AKI) is limited to optimising supportive care and renal replacement therapy. Unfortunately, there are no disease modifying interventions available in clinical practice, which have significant implications to short- and long-term outc
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16

McDonald, Jacqueline. "Conditional immortalisation of myeloid-precursors to model innate immunity." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/45729/.

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The prevalence of fungal infections is on the rise due to the increase of immune suppressed individuals. Neutrophils are key immune cells in the fight against fungal infections. The study of neutrophil biology is hampered by the short lived nature of the cells and the fact that they cannot be easily genetically modified. In this thesis, I generate and characterise myeloid precursor cell lines that can be genetically manipulated and differentiated into functional neutrophils. These in vitro generated neutrophils were adoptively transferred into live animals and tracked during inflammatory respo
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17

Karnish, Candace. "The Effect of Repeated Cold Exposure on Insect Immunity." Thesis, Southern Illinois University at Edwardsville, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10844278.

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<p> Most studies examining effects of extreme temperature on insect immunity have focused on negative impacts of high-temperature exposure. Although largely unexplored, a recent study suggests that repeated exposure to freezing temperature may enhance insects&rsquo; ability to survive microbial challenge. To determine if repeated low-temperature exposure impacts innate immunity of the goldenrod gall fly, <i>Eurosta solidaginis</i>, we counted hemocyte number, measured phenoloxidase activity and assessed antibacterial activity, and I examined up-regulation of immune-related genes in winter-accl
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18

Vira, Alykhan. "Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens." Doctoral thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/13966.

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During the last decade, cholinergic signaling via acetylcholine and its receptors has emerged as an important regulator of immunity. Acetylcholine binds to and signals through two types of receptors; nicotinic and muscarinic receptors. Studies have shown that signaling through nicotinic receptors, particularly the α7 subtype on macrophages has potent anti-inflammatory effects. However, the role for muscarinic receptor has not yet been conclusively characterized. In this study, we demonstrate that M3 muscarinic receptor subtype is required for optimal protective immunity to two pathogens; the
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19

Nyakeriga, Alice. "Relation of nutritional status, immunity, hemoglobinopathy and falciparum malaria infection." Doctoral thesis, Stockholms universitet, Wenner-Grens institut för experimentell biologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-369.

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The interaction between nutritional status and malaria disease is complex and often controversial. Nutritional deficiencies (macro- or micro-nutrient) are thought to lead to malnutrition with subsequent susceptibility to malaria infection. On the other hand severe malaria or repeated malaria infections lead to malnutrition. While the cause and effect are difficult to attribute, micronutrient deficiencies such as iron deficiency and malaria infection often co-exist and show complex interactions leading to mutually reinforced detrimental clinical effects. That iron deficiency has adverse effects
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20

Lensmar, Catarina. "Early airway inflammation in allergic asthma : aspects of pulmonary innate immunity /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4463-6/.

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21

Zeng, Yi. "Optimizing immunity against BCR-ABL positive leukemia." Diss., The University of Arizona, 2003. http://hdl.handle.net/10150/289963.

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Chronic myelogenous leukemia (CML) is a clonal disorder characterized by proliferation of cells expressing BCR-ABL fusion proteins. The BCR-ABL fusion proteins are tumor-specific antigens and represent reasonable targets for immunologic approaches against CML. We have utilized a free-solution-isoelectric focusing technique (FS-IEF) to obtain chaperone rich cell lysates (CRCL) from tumors. We found that CRCL derived from 12B1, an aggressive bcr-abl⁺ murine tumor activated dendritic cells (DCs) by upregulating CD40 and MHC-II on their cell surface and stimulating them to produce interleukin-12 (
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22

Hsieh, Hsiang Chuan. "Checkpoint modulation of T cell immunity by novel fusion cytokines." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121154.

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Functional immunity requires a balanced T cell immune response, which entails the maintenance of de novo production (i.e. TCR repertoire diversity) and the appropriate differentiation of effector subsets at the periphery. However, numerous pathogenic changes can perturb this homeostasis. On the one hand, diminished thymopoiesis or exhausted effectors cause immune dysfunction, leading to the persistence of virally infected or cancerous cells. Unrestrained immune reaction, on the other hand, can cause significant tissue damage. The main objective of my thesis therefore was to develop novel thera
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23

Gerada, Chelsea. "Modulation of Innate Immunity by Varicella Zoster Virus." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/22344.

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Varicella zoster virus (VZV) is a ubiquitous human alphaherpesvirus, which causes varicella (chicken pox) during primary infection. During primary infection, the virus infects the skin and gains access to sensory nerve termini. Through retrograde transport, VZV infects neurons in the dorsal root ganglia (DRG) where the virus establishes lifelong latency. VZV can reactivate to cause herpes zoster (shingles), which encompasses a broad variety of complications such as post herpetic neuralgia (PHN), which is defined as neuropathic pain that persists at least 3 months beyond the appearance of the h
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24

Parlet, Corey Patrick. "Mechanisms by which chronic ethanol consumption impairs cutaneous immunity." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/4712.

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The immunosuppressive effects of chronic alcohol abuse are profound, wide-ranging and readily apparent at the body's barriers. In the skin, alcoholism is associated with an increased incidence and severity of infection; yet the precise immunologic alterations responsible remain poorly understood. Cutaneous homeostasis and immunity are afforded via coordinated efforts of tissue-specific immune cell networks. Here, the Meadows-Cook murine model of alcoholism was used to investigate the impact of chronic ethanol (EtOH) exposure upon the following: 1) the composition and function of skin-resident
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25

Jun, Janice. "THE OFFENSE-DEFENSE BALANCE IN IMMUNITY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1467997330.

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26

Nyirenda, Tonney. "Natural immunity to Salmonella in humans." Thesis, University of Liverpool, 2015. http://livrepository.liverpool.ac.uk/2010084/.

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Background: Salmonella bacteraemia is an important public health problem in children from sub Saharan Africa (SSA). Understanding what constitutes natural acquired immunity to Salmonella is crucial for the development of Salmonella vaccine. It was hypothesized that natural Salmonella exposure within the GIT and peripheral blood induces the generation of specific-antibodies and T cells and these might provide protection to subsequent Salmonella infection. Methods: Natural acquisition of antibody and T cell immunity to Salmonella was investigated in healthy and Salmonella infected Malawian child
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27

Mellroth, Peter. "Peptidoglycan Recognition Proteins : Major Regulators of Drosophila Immunity." Doctoral thesis, Stockholm : Department of Genetics, Microbiology and Toxicology, Stockholm University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-646.

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28

Draganov, Dobrin Draganov. "MFG-E8 Blockade Enhances Tumor Immunity in a Murine Breast Cancer Model." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10512.

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Milk fat globule - epidermal growth factor - factor 8 protein (MFG-E8) is an important mediator of the tolerogenic functions of GM-CSF, and a dominant-negative RGE mutant augments the therapeutic potential of irradiated, GM-CSF-secreting tumor vaccines (GVAX) in the MFG-E8-negative B16 melanoma model. The frequent expression of MFG-E8 in various solid and hematological malignancies, however, prompted us to investigate the effect of the RGE mutant in a MFG-E8-positive transplantable breast tumor model. Here, we report that MFG-E8 blockade augmented anti-tumor humoral responses and modulated imm
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29

White, Lisa Jane. "A theoretical study of the effects of immunity on infectious disease transmission." Thesis, University of Warwick, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343535.

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30

Klarquist, Jared. "Type I IFN control of sterile inflammation: Uncovering mechanisms behind autoimmunity and antitumor immunity." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1467988023.

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31

Rodríguez, Ariane. "Mucosal immunity in the respiratory tract : The role of IgA in protection against intracellular pathogens." Doctoral thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-388.

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<p>The lungs and upper airways are mucosal surfaces that are common site for infection with an enormous variety of inhaled pathogens. Therefore, induction of immune responses in the respiratory tract is crucial for protection against respiratory diseases.</p><p>One of the pathogens infecting the host via the respiratory tract is <i>Mycobacterium Tuberculosis</i>. The reported efficacy of the currently used Bacillus Calmette-Guérin (BCG) vaccine against tuberculosis is highly variable, ranging from 50% against pulmonary tuberculosis to 80% against disseminated tuberculosis. Recently, the curren
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32

McCluskie, Michael J. "Strategies for the induction of mucosal immunity against hepatitis B virus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0019/NQ45183.pdf.

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33

Rongcun, Yang. "The HER2/neu oncoprotein and dendritic cells in immunity against tumors /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4052-5/.

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34

Hardie, Laura J. "The effects of dietary vitamins, lipids and temperature on teleost immunity." Thesis, University of Aberdeen, 1991. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU603176.

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Singular or dual dietary depletions of vitamins C and E in Atlantic salmon parr increased susceptibility to Aeromonas salmonicida challenge. An array of immune parameters were evaluated to identify the involvement of these vitamin depletions on the immune response. Dietary vitamin E levels in salmon had no impact on haematological parameters, total serum protein or lysozyme levels. Similarly, dietary vitamin E levels did not affect leucocyte antibody production, macrophage activating factor (MAF) release and respiratory burst (RB) phenomena. However, haemolytic and opsonic properties of comple
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35

Seipp, Robyn Patricia. "The role of tapasin and its isoforms in antigen presentation and tumor immunity." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/558.

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Major Histocompatibility Complex (MHC) Class I molecules present peptides to CD8⁺ T cells and are essential for most adaptive immune responses. The first described-spliced tapasin (“isoform 1”) plays a critical role in MHC-I antigen presentation by facilitating peptide loading onto MHC-I molecules in the endoplasmic reticulum (ER). This thesis examines the expression, localization and function of two novel, alternatively-spliced isoforms of human tapasin that lack exon 7 (“isoform 2”) or both exons 6 and 7 (“isoform 3”). Isoform 1 contains a di-lysine ER-retention motif; the two novel isoforms
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36

Palgen, Jean-Louis. "Characterization of the innate immunity elicited by vaccination and its interactions with adaptive immunity, depending on prime-boost delay." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS146.

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La vaccination est l'un des plus grands progrès réalisés en santé publique. Toutefois, malgré de nombreuses connaissances sur le système immunitaire, de nombreux pans d’ombre empêchent la conception de vaccins contre des pathogènes complexes. Pour pallier ce problème, une meilleure compréhension des modes d'action des vaccins est requise. En particulier, la plupart des vaccins nécessitent plusieurs immunisations pour induire une mémoire immunitaire adaptative au long terme, mais l'impact du délai entre primo-vaccination, induisant une mémoire primaire, et rappel(s) la restimulant pour générer
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37

Siggs, Owen M. "Forward genetic analysis of mammalian immunity." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:caaf6ee7-e2b1-4fe1-a47c-1d6b76b249a4.

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Mutation, whether spontaneous or induced, is the premier tool for understanding gene function. One approach is to create mutations in a specific gene, and then use the resulting cell or organism to search for a phenotype. An alternative is to create mutations at random, and focus first on the identification of phenotypes. The mutation that underlies a phenotype can then be tracked down, forming the foundation of testable hypotheses. Using random chemical mutagenesis in mice, I have identified 20 heritable phenotypes affecting either the innate or adaptive branches of immunity. The genetic basi
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Anderson, Elinor Julie Rae. "The role of the CCX-CKR chemokine receptor in immunity and tolerance." Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/2325/.

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CCX-CKR is an atypical chemokine receptor for the homeostatic chemokines CCL19, CCL21 and CCL25. CCL19 and CCL21 are also ligands for CCR7 and are crucial for the induction of antigen specific immunity and tolerance, whereas CCL25 is the sole ligand for CCR9 and is involved in the recruitment of immune effector cells to the small intestine. CCX-CKR does not signal after binding its ligands, as determined by a failure to induce the rapid increase in intracellular calcium that is typical of G-protein mediated signalling. CCX-CKR also does not become desensitised to chemokine binding and therefor
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39

Goyal, Girija. "Novel Role of PPAR-Gamma in GM-CSF Induced Anti-Tumor Immunity." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14226102.

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Granulocyte macrophage colony stimulating factor (GM-CSF) mediates context dependent anti- or pro-inflammatory functions through cells of the myeloid lineage. GM-CSF signaling induces the expression of the transcription factor peroxisome proliferator-activated receptor gamma (PPAR-γ). We examined the role PPAR-γ in myeloid cells in the anti-tumor response to GVAX, a GM-CSF based cancer immunotherapy using the B16 model of murine melanoma. We found that selective loss of PPAR-γ in the myeloid lineage using LysM-Cre reduces the efficacy of GVAX which could not be explained by known mechanisms.
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Yu, Ting-Fong. "The synthesis and evaluation of chemical adjuvants for modulating immunity." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4306/.

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Threitol Ceramide (ThrCer) is a truncated, non-glycosidic, acyclic analogue of the prototypical CD1d agonist, α-GalCer, and has potential therapeutic application. Synthesis and biological assessment of a series of deoxy ThrCer analogues showed that all three hydroxyl groups in the sugar head-group are necessary for effective iNKT cell activation. Postulating that the increased conformational flexibility of the acyclic head-group in ThrCer accounts for its lower biological activity compared to α-GalCer, analogues were prepared in which the threitol unit is contained within a carbocycle. Biologi
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41

Lange, Shannon Marie. "L-Citrulline Metabolism Orchestrates Anti-mycobacterial Immunity." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1511882575584058.

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42

See, Sarah Bihui. "Outer membrane protein immunity to Pasteurella pneumotropica and the interaction of allergy." University of Western Australia. School of Paediatrics and Child Health, 2010. http://theses.library.uwa.edu.au/adt-WU2010.0103.

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[Truncated abstract] Infectious and allergic diseases of the respiratory tract are major contributors to global mortality, morbidity and economic burden. Bacterial infections such as pneumonia and otitis media are important diseases, especially in children, while allergic diseases such as asthma and allergic rhinitis afflict up to 30% of the world's population. A confounding aspect of respiratory disease is the evidence of a complex relationship between respiratory allergy and respiratory infection, with infection suggested to both promote and prevent the pathogenesis of allergic disease. Addi
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43

Yi, Xin. "RNASE L MANIPULATES MACROPHAGES IN INNATE IMMUNITY AND TUMOR GROWTH." Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1342151674.

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44

Tessmer, Marlowe S. "Biological functions and molecular associations of the killer cell lectin-like receptor G1." View abstract/electronic edition; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318364.

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45

Labbé, Katherine. "Genetic and functional characterization of modulators of the inflammasome in infection and immunity." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114141.

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Cell death and inflammation are two central, tightly coupled, innate immune processes. The inflammasome triggers both in response to pathogens and tissue damage. This cytosolic signalling complex contributes to host-defence, tissue repair and inflammatory disease, but the factors governing inflammasome activity are poorly characterized. This thesis examines the function of inflammasome modulators in infection and immunity. Inflammasome activity is antagonized by caspase-12. In humans, caspase-12 expression is limited to populations in geographical locations that overlap with regions endemic fo
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46

Wu, Muzo. "Innate Immunity Immunomodulators in Post-Influenza Bacterial Pneumonia." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:16121158.

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Post-influenza bacterial pneumonia is a major cause of morbidity and mortality worldwide. One mechanism for enhanced susceptibility to bacterial infection after influenza is down-regulation of a major phagocytic receptor on alveolar macrophages, macrophage receptor with collagenous structure (MARCO), by interferon- (IFN-), which leads to diminished bacterial clearance. Nrf2, a transcription factor that regulates expression of antioxidant genes, is one of the regulators of MARCO expression. We show that the Nrf2 activator sulforaphane improves MARCO expression and bacterial phagocytosis in al
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47

Beamer, Gillian L. "IMMUNOLOGIC MECHANISMS AND PREDICTORS OF SUSCEPTIBILITY TO MYCOBACTERIUM TUBERCULOSIS." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243993142.

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48

Moberg, Lisa. "The Role of Innate Immunity in Islet Transplantation : Clinical and Experimental Studies." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4260.

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49

Bordon, Yvonne. "The role of the D6 chemokine receptor in immunity and inflammation." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/6552/.

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D6 is a novel chemokine receptor, homologous to other members of the CC-chemokine receptor family, which recognises a number of inflammatory CC-chemokines with high affinity. The aims of this thesis were to further our understanding of the biology of D6, chiefly through characterisation of immune responses in D6-deficient animals. Firstly, as described in Chapter 3, I analysed the cellular composition of lymphoid tissues of D6 KO mice. These studies revealed higher proportions of CD11c+ and F4/80+ cells in the D6 KO spleen compared with WT controls, suggesting that increased accumulation of my
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Balogun, Halima A. "Immunological characteristics of recombinant fragments of the Plasmodium falciparum blood-stage antigen Pf332." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-60540.

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Effective malaria vaccine might help improve control strategies against malaria, but the complexity of interactions between the parasite and its hosts poses challenges. The asexual blood stage P. falciparum antigen Pf332 has potentials as one of the proteins in understanding the complex host-parasite interactions. The interest in Pf332 as a target for parasite neutralizing antibodies, evolved from previous studies demonstrating that Pf332-reactive antibodies inhibits parasite growth in vitro. The presence of natural P. falciparum infection also indicated that Pf332 has the ability to induce pr
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