Academic literature on the topic 'Immunocompromised Mice'

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Journal articles on the topic "Immunocompromised Mice"

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Liou, Jiin-Tarng, Fu-Chao Liu, Chih-Chieh Mao, Ying-Shu Lai, and Yuan-Ji Day. "Inflammation Confers Dual Effects on Nociceptive Processing in Chronic Neuropathic Pain Model." Anesthesiology 114, no. 3 (2011): 660–72. http://dx.doi.org/10.1097/aln.0b013e31820b8b1e.

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Background Although inflammation induces pain, immune cells also produce mediators that can effectively counteract it. To further elucidate the role of the immune response, we analyzed the relationship of pain behavior, several inflammatory signals, and opioid peptides using partial sciatic nerve ligation in mice at different levels of immunocompromise. Methods Sciatic nerves of C57BL/6C, nonobese diabetic (NOD), or nonobese diabetic-severe combined immune deficiency (NOD-SCID) mice were partially ligated. Responses to mechanical and radiant heat stimuli were observed. Inflammation was detecte
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Badell, Edgar, Claude Oeuvray, Alicia Moreno, et al. "Human Malaria in Immunocompromised Mice." Journal of Experimental Medicine 192, no. 11 (2000): 1653–60. http://dx.doi.org/10.1084/jem.192.11.1653.

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We have recently described that sustained Plasmodium falciparum growth could be obtained in immunodeficient mice. We now report the potential of this new mouse model by assaying the effect of the passive transfer of antibodies (Abs) which in humans have had a well-established effect. Our results show that the total African adult hyperimmune immunoglobulin Gs (HI-IgGs) strongly reduce P. falciparum parasitemia similarly to that reported in humans, but only when mice are concomitantly reconstituted with human monocytes (HuMNs). In contrast, neither HI-IgGs nor HuMNs alone had any direct effect u
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Dhong, Kyu-Ree, Ha-Kyoung Kwon, and Hye-Jin Park. "Immunostimulatory Activity of Cordyceps militaris Fermented with Pediococcus pentosaceus SC11 Isolated from a Salted Small Octopus in Cyclophosphamide-Induced Immunocompromised Mice and Its Inhibitory Activity against SARS-CoV 3CL Protease." Microorganisms 10, no. 12 (2022): 2321. http://dx.doi.org/10.3390/microorganisms10122321.

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In this study, we investigated the immune-enhancing and anti-viral effects of germinated Rhynchosia nulubilis (GRC) fermented with Pediococcus pentosaceus SC11 (GRC-SC11) isolated from a salted small octopus. The cordycepin, β-glucan, and total flavonoid contents increased in GRC after SC11 fermentation. GRC-SC11 inhibits 3CL protease activity in severe acute respiratory syndrome-associated coronavirus (SARS-CoV). GRC-SC11 significantly increased thymus and spleen indices in immunocompromised mice. The rate of splenocyte proliferation was higher in GRC-SC11-treated immunocompromised mice than
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Kot, Karolina, Daria Kołodziej, Patrycja Kupnicka, Danuta Izabela Kosik-Bogacka, and Natalia Łanocha-Arendarczyk. "Concentrations of PGE2 and TXB2 in the Eyes of Mice with Disseminated Acanthamoebiasis." Pathogens 11, no. 4 (2022): 438. http://dx.doi.org/10.3390/pathogens11040438.

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Previous studies have shown that Acanthamoeba spp. may invade the eyes by migrating along the optic nerve to the eyes from the brain. This study aimed to confirm the presence of inflammation in the eyes of mice with disseminated acanthamoebiasis by examining prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) concentrations in the eyes of immunocompetent and immunocompromised mice intranasally inoculated with Acanthamoeba spp. The PGE2 concentration was statistically significantly lower in the immunocompromised amoebae-infected mice on 8 dpi compared with the noninfected group of animals, and it
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Perry, Luba, Uri Merdler, Maria Elishaev, and Shulamit Levenberg. "Enhanced Host Neovascularization of Prevascularized Engineered Muscle Following Transplantation into Immunocompetent versus Immunocompromised Mice." Cells 8, no. 12 (2019): 1472. http://dx.doi.org/10.3390/cells8121472.

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Engineering of functional tissue, by combining either autologous or allogeneic cells with biomaterials, holds promise for the treatment of various diseases and injuries. Prevascularization of the engineered tissue was shown to enhance and improve graft integration and neovascularization post-implantation in immunocompromised mice. However, the neovascularization and integration processes of transplanted engineered tissues have not been widely studied in immunocompetent models. Here, we fabricated a three-dimensional (3D) vascularized murine muscle construct that was transplanted into immunocom
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Winslow, Gary M., Eric Yager, Konstantin Shilo, Doris N. Collins, and Frederick K. Chu. "Infection of the Laboratory Mouse with the Intracellular Pathogen Ehrlichia chaffeensis." Infection and Immunity 66, no. 8 (1998): 3892–99. http://dx.doi.org/10.1128/iai.66.8.3892-3899.1998.

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ABSTRACT To determine the basis of susceptibility and resistance to human monocytic ehrlichiosis (HME), immunocompetent and immunocompromised mice were infected with Ehrlichia chaffeensis and bacterial loads were measured by PCR and by immunohistochemistry. Immunocompetent (C.B-17 and C57BL/6) mice cleared the bacteria within 10 days, but immunocompromised SCID and SCID/BEIGE mice developed persistent infection in the spleen, liver, peritoneal cavity, brain, lung, and bone marrow and became moribund within 24 days. Both immunocompromised strains lack T and B lymphocytes, but the SCID/BEIGE str
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Scarff, Jennifer M., and Joanna B. Goldberg. "Vaccination against Pseudomonas aeruginosa Pneumonia in Immunocompromised Mice." Clinical and Vaccine Immunology 15, no. 2 (2007): 367–75. http://dx.doi.org/10.1128/cvi.00419-07.

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ABSTRACT Immunocompromised patients are highly susceptible to infection with Pseudomonas aeruginosa. Our laboratory previously showed that intranasal administration of an attenuated Salmonella strain expressing the P. aeruginosa lipopolysaccharide O antigen was effective in clearing bacteria and preventing mortality in wild-type mice after intranasal challenge. We were interested in investigating the efficacy of this vaccine strategy in immunocompromised mice. Mice rendered leukopenic or neutropenic by intraperitoneal treatment with cyclophosphamide (Cy) or RB6-8C5 antibody, respectively, were
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Cole, G. T., K. T. Lynn, K. R. Seshan, and L. M. Pope. "Gastrointestinal and systemic candidosis in immunocompromised mice." Medical Mycology 27, no. 6 (1989): 363–80. http://dx.doi.org/10.1080/02681218980000491.

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Gombert, M. E., L. B. Berkowitz, T. M. Aulicino, and L. duBouchet. "Therapy of pulmonary nocardiosis in immunocompromised mice." Antimicrobial Agents and Chemotherapy 34, no. 9 (1990): 1766–68. http://dx.doi.org/10.1128/aac.34.9.1766.

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Kraft, W. G., P. T. Johnson, B. C. David, and D. R. Morgan. "Cutaneous infection in normal and immunocompromised mice." Infection and Immunity 52, no. 3 (1986): 707–13. http://dx.doi.org/10.1128/iai.52.3.707-713.1986.

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Dissertations / Theses on the topic "Immunocompromised Mice"

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Tsang, Eric. "Effects of the inflammatory response to HEMA-MMA microencapsulated cell survival, studies in immunocompromised mice." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq62926.pdf.

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Jayal, Priyanka. "Establishment of human ectopic liver tissue in immunocompromised mice as a model for Hepatitis C Virus studies." Thesis, 2018. https://etd.iisc.ac.in/handle/2005/4876.

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Infection with hepatitis C virus (HCV) leads to an inflammatory condition which may progress to liver cirrhosis and in some cases, hepato-cellular carcinoma. Though, new drugs are being added to the list of HCV therapeutics, there is need for newer and safer drugs for the management of the disease. There is a paucity of animal models because HCV infects only humans and chimpanzees. Towards establishing a small animal model that can be used for testing the efficacy of anti-HCV drugs, it was proposed to establish an ectopic human liver in an immunocompromised strain of mouse, namely, nude mouse.
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Books on the topic "Immunocompromised Mice"

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Effects of the inflammatory response to HEMA-MMA microencapsulated cell survival: Studies in immunocompromised mice. National Library of Canada, 2000.

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Book chapters on the topic "Immunocompromised Mice"

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Gray, Brian M., and Kathryn A. Eaton. "Adoptive Transfer of Splenocytes to Immunocompromised Mice." In Helicobacter Species. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-005-2_14.

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Griffin, Bryan D., David Safronetz, and Darwyn Kobasa. "Evaluating Zika Virus Pathogenesis in Immunocompromised Mice." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0581-3_3.

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Norelli, Margherita, Barbara Camisa, and Attilio Bondanza. "Modeling Human Graft-Versus-Host Disease in Immunocompromised Mice." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3338-9_12.

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Greene, Carl, and Hiranmoy Das. "Development of Cutaneous Wound in Diabetic Immunocompromised Mice and Use of Dental Pulp–Derived Stem Cell Product for Healing." In Methods in Molecular Biology. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0845-6_3.

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Dobrolecki, Lacey E., and Michael T. Lewis. "Surgical Procedure for Implantation of Human Tumor Tissue into the Epithelium-Free Mammary Fat Pad of Immunocompromised Mice to Generate Patient-Derived Xenografts (PDX)." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2193-6_10.

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Jana, Rishika, Souvik Karmakar, Bishal Hazra, Subhadeep Roy, and Jayasri Das Sarma. "Mice as an Experimental Model to Understand the Pathobiology of Diseases." In Rodents and Their Role in Ecology, Medicine and Agriculture [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.1001835.

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Murine models are widely used in scientific research because they share many genetic similarities with humans, making them a valuable tool for studying various diseases. C57BL/6 is an experimental mouse model to study the demyelination and inflammation etiology of Multiple Sclerosis (MS). Intracranial inoculation of neurotropic murine β-coronavirus strain of Mouse hepatitis virus in C57BL/6 mice induces demyelination with or without axonal loss, providing many insights regarding the mechanism of MS as well as SARS-CoV-2 mediated pulmonary and neuro pathology in humans. By selectively using kno
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Saini, Sheetal, Rajinder Kumar, and Rajeev K. Tyagi. "Stable Artesunate Resistance in A Humanized Mouse Model of Plasmodium falciparum." In Plasmodium Species and Drug Resistance. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.100381.

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Plasmodium falciparum, the most devastating human malaria parasite, confers higher morbidity and mortality. Although efforts have been made to develop an effective malaria vaccine, stage- and species-specific short-lived immunity crippled these efforts. Hence, antimalarial drug treatment becomes a mainstay for the treatment of malaria infection in the wake of the unavailability of an effective vaccine. Further, there has been a wide array of antimalarial drugs effective against various developmental stages of P. falciparum due to their different structures, modes of action, and pharmacodynamic
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Nelson, Kenrad E., and Thira Sirisanthana. "Penicilliosis." In Clinical Mycology. Oxford University PressNew York, NY, 2003. http://dx.doi.org/10.1093/oso/9780195148091.003.0023.

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Abstract More than 200 species of the Penicillium genus have been described. Penicillium organisms are abundant in nature and are common laboratory contaminants. However, Penicillium marneffei is the only dimorphic species. The organism is commonly responsible for disseminated invasive infections in humans with HIV infection or AIDS in the endemic areas of Southeast Asia and southern China. Penicillium marneffei has also been found to cause natural infections in several species of rodents in the endemic areas and rodents can be infected experimentally. Penicillium marneffei was originally isol
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Vandevelde, Karen M. "Scabies." In The HIV Manual. Oxford University PressNew York, NY, 1996. http://dx.doi.org/10.1093/oso/9780195100365.003.0045.

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Abstract Scabies is an infestation caused by the mite Sarcoptes scabiei and is transmitted by close personal contact. It is a common cause of pruritus in the general population as well as among HIV-infected individuals. The common (classic) form of scabies is characterized by severe pruritus. Most infected persons harbor fewer than one dozen mites at any one time. Crusted scabies, also known as Norwegian or hyperkeratotic scabies, is a different and uncommon form of scabies. It occurs primarily in immunocompromised, elderly, or institutionalized patients. Among HIV-infected patients, it genera
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Conference papers on the topic "Immunocompromised Mice"

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Castillo-Pichardo, Linette, Luis A. Cubano, José F. Rodríguez-Orengo, and Suranganie Dharmawardhane. "Abstract 4868: Dietary resveratrol promotes breast cancer progression in immunocompromised mice." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-4868.

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Walters, Dustin M., Catharine R. Cowan, Sara J. Adair, et al. "Abstract 1592: Targeting proliferative signals in patient-derived pancreatic cancers propagated orthotopically in immunocompromised mice." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-1592.

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Rafat, Marjan, Marta Vilalta, Todd A. Aguilera, Amato J. Giaccia, and Edward E. Graves. "Abstract 5124: Tumor and immune cell infiltration are enhanced by irradiation of normal tissues in immunocompromised mice." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-5124.

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Oswald, Eva, Kerstin Klingner, Benedikt Hammerich, et al. "Abstract 4210: Patient-derived models of human acute myeloid and lymphoid leukemia in immunocompromised mice for preclinical drug development." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4210.

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Knizia, Henrike, Michael A. Batey, Gilberto S. Almeida, et al. "Abstract 478: Development of an orthotopic model for human malignant bone diseases in immunocompromised NOD.Cg-PrkdcscidIl2rgtmlwjl/szj(NSG) mice." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-478.

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Oswald, Eva, Vitor E. Santo, Albin Rudisch, et al. "Abstract 630: Co-injection of human fibroblasts significantly enhances tumorigenicity of orthotopically implanted human non-small cell lung cancer cells in immunocompromised mice." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-630.

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Oswald, Eva, Kerstin Klingner, Ralph Waesch, Katja Zirlik, Monika Engelhardt, and Julia B. Schüler. "Abstract 3926: Influence of tumor microenvironment on engraftment capacity of hematological cell lines in immunocompromized mice." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3926.

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Carr, Rachel, Justin Halim, Rebecca Fliorent, Henry Fraimow, Dejan Nikolic, and Valerie Carabetta. "Characterization of Antibiotic Susceptibility Profiles of Extensively- and Pan-Drug Resistant Acinetobacter Baumannii Clinical Isolates." In 27th Annual Rowan-Virtua Research Day. Rowan University Libraries, 2023. https://doi.org/10.31986/issn.2689-0690_rdw.stratford_research_day.96_2023.

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Acinetobacter baumannii is an opportunistic pathogen common in intensive care units (ICUs), particularly among immunocompromised individuals. Nosocomial A. baumannii infections have become increasingly problematic in recent years, as these bacteria rapidly acquire antibiotic resistance, leading to the emergence of multidrug, extensively drug and pan drug-resistant (MDR, XDR, and PDR, respectively) isolates. Recently, Cooper University Hospital (CUH) experienced a large increase in highly drug-resistant A. baumannii infections, which had a mortality rate of 60%. Oftentimes, physicians had to tu
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ROCHA, Sofia Marques, Bruna Hudson Neves PEREIRA, Emanuelle Silva OLIVEIRA, Letícia Santos JUNQUEIRA, and Glenda Ribeiro OLIVEIRA. "RELEVANCE OF THE HEALTH CONDITION AND CLINICAL CHARACTERISTICS OF SPOROTRICHOSIS." In SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 2021 INTERNATIONAL VIRTUAL CONFERENCE. DR. D. SCIENTIFIC CONSULTING, 2022. http://dx.doi.org/10.48141/sbjchem.21scon.41_abstract_rocha.pdf.

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Feline sporotrichosis is a zoonosis caused by S. brasiliensis, and it presents a degree of great underreporting due to its contamination. Caused by inoculation directly into the skin, in most cases through scratches or bites by infected animals. With its first diagnosis in 1907 among naturally infected mice. The study presents information on the health of the animal, composed of 24 felines of both sexes, obtaining information through questionnaires about food along with vaccination, deworming, and ectoparasites control. In addition to depicting the types of injuries and body parts such as head
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