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Journal articles on the topic 'IMMUNOESCAPE'

Author: Grafiati
Published: 11 March 2023

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1

Concha-Benavente, Fernando, Raghvendra M. Srivastava, Soldano Ferrone, and Robert L. Ferris. "EGFR-mediated tumor immunoescape." OncoImmunology 2, no. 12 (2013): e27215. http://dx.doi.org/10.4161/onci.27215.

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2

QUESNEL, BRUNO. "Tumor dormancy and immunoescape." APMIS 116, no. 7-8 (2008): 685–94. http://dx.doi.org/10.1111/j.1600-0463.2008.01163.x.

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3

Mazzolini, Guillermo. "Immunotherapy and immunoescape in colorectal cancer." World Journal of Gastroenterology 13, no. 44 (2007): 5822. http://dx.doi.org/10.3748/wjg.v13.i44.5822.

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4

Van hede, Dorien, Inge Langers, Philippe Delvenne, and Nathalie Jacobs. "Origin and immunoescape of uterine cervical cancer." La Presse Médicale 43, no. 12 (2014): e413-e421. http://dx.doi.org/10.1016/j.lpm.2014.09.005.

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5

Sauleda, Jaume, Francisco Javier Verdú, Sergio Scrimini, Ernest Sala, and Jaume Pons. "Immunoescape the link between emphysema and lung cancer?" Journal of Thoracic Disease 11, S3 (2019): S329—S330. http://dx.doi.org/10.21037/jtd.2018.12.133.

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6

Takasu, Chie, Shoko Yamashita, Yuji Morine, et al. "The role of the immunoescape in colorectal cancer liver metastasis." PLOS ONE 16, no. 11 (2021): e0259940. http://dx.doi.org/10.1371/journal.pone.0259940.

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The expression of programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) indicate the efficacy of anti-PD-1/PD-L1 therapy in colorectal cancer (CRC), but are less useful for monitoring the efficacy of therapy of CRC liver metastasis (CRLM). This study investigated the effects of immune molecules on the prognosis of CRLM. We enrolled 71 patients with CRLM who underwent curative resection for CRC. We used immunohistochemistry to analyze the expression of PD-1, PD-L1, indoleamine-pyrrole 2,3-dioxygenase (IDO), and CD163 (a marker of tumor-associated macrophages [TAMs]) in metastatic tumo
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7

deCampos-Lima, Pedro-Otavio, Jelena Levitskaya, Teresa Frisan, and Maria G. Masucci. "Strategies of immunoescape in Epstein-Barr virus persistence and pathogenesis." Seminars in Virology 7, no. 1 (1996): 75–82. http://dx.doi.org/10.1006/smvy.1996.0009.

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8

Yaguchi, Tomonori, Hidetoshi Sumimoto, Chie Kudo-Saito, et al. "The mechanisms of cancer immunoescape and development of overcoming strategies." International Journal of Hematology 93, no. 3 (2011): 294–300. http://dx.doi.org/10.1007/s12185-011-0799-6.

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9

Ghiringhelli, François, Mélanie Bruchard, Fanny Chalmin, and Cédric Rébé. "Production of Adenosine by Ectonucleotidases: A Key Factor in Tumor Immunoescape." Journal of Biomedicine and Biotechnology 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/473712.

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It is now well known that tumor immunosurveillance contributes to the control of cancer growth. Many mechanisms can be used by cancer cells to avoid the antitumor immune response. One such mechanism relies on the capacity of cancer cells or more generally of the tumor microenvironment to generate adenosine, a major molecule involved in antitumor T cell response suppression. Adenosine is generated by the dephosphorylation of extracellular ATP released by dying tumor cells. The conversion of ATP into adenosine is mediated by ectonucleotidase molecules, namely, CD73 and CD39. These molecules are
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Wu, Lei, Yanquan Xu, Huakan Zhao та ін. "FcγRIIB potentiates differentiation of myeloid-derived suppressor cells to mediate tumor immunoescape". Theranostics 12, № 2 (2022): 842–58. http://dx.doi.org/10.7150/thno.66575.

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11

Ogino, Takeshi, Shigetaka Moriai, Yoshiya Ishida, et al. "Association of immunoescape mechanisms with Epstein-Barr virus infection in nasopharyngeal carcinoma." International Journal of Cancer 120, no. 11 (2007): 2401–10. http://dx.doi.org/10.1002/ijc.22334.

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12

Ferris, Robert L., Elizabeth M. Jaffee, and Soldano Ferrone. "Tumor Antigen–Targeted, Monoclonal Antibody–Based Immunotherapy: Clinical Response, Cellular Immunity, and Immunoescape." Journal of Clinical Oncology 28, no. 28 (2010): 4390–99. http://dx.doi.org/10.1200/jco.2009.27.6360.

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PurposeTumor antigen (TA) –targeted monoclonal antibodies (mAb), rituximab, trastuzumab, and cetuximab, are clinically effective for some advanced malignancies, especially in conjunction with chemotherapy and/or radiotherapy. However, these results are only seen in a subset (20% to 30%) of patients. We discuss the immunologic mechanism(s) underlying these clinical findings and their potential role in the variability in patients' clinical response.MethodsWe reviewed the evidence indicating that the effects of TA-targeted mAb-based immunotherapy are mediated not only by inhibition of signaling p
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13

Tirapu, Iñigo, Eduardo Huarte, Cristiana Guiducci, et al. "Low Surface Expression of B7-1 (CD80) Is an Immunoescape Mechanism of Colon Carcinoma." Cancer Research 66, no. 4 (2006): 2442–50. http://dx.doi.org/10.1158/0008-5472.can-05-1681.

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14

Romano, Veronica, Immacolata Belviso, Alessandro Venuta, et al. "Influence of Tumor Microenvironment and Fibroblast Population Plasticity on Melanoma Growth, Therapy Resistance and Immunoescape." International Journal of Molecular Sciences 22, no. 10 (2021): 5283. http://dx.doi.org/10.3390/ijms22105283.

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Cutaneous melanoma (CM) tissue represents a network constituted by cancer cells and tumor microenvironment (TME). A key feature of CM is the high structural and cellular plasticity of TME, allowing its evolution with disease and adaptation to cancer cell and environmental alterations. In particular, during melanoma development and progression each component of TME by interacting with each other and with cancer cells is subjected to dramatic structural and cellular modifications. These alterations affect extracellular matrix (ECM) remodelling, phenotypic profile of stromal cells, cancer growth
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15

Gabriele, Caterina, Licia E. Prestagiacomo, Giovanni Cuda, and Marco Gaspari. "Mass Spectrometry-Based Glycoproteomics and Prostate Cancer." International Journal of Molecular Sciences 22, no. 10 (2021): 5222. http://dx.doi.org/10.3390/ijms22105222.

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Aberrant glycosylation has long been known to be associated with cancer, since it is involved in key mechanisms such as tumour onset, development and progression. This review will focus on protein glycosylation studies in cells, tissue, urine and serum in the context of prostate cancer. A dedicated section will cover the glycoforms of prostate specific antigen, the molecule that, despite some important limitations, is routinely tested for helping prostate cancer diagnosis. Our aim is to provide readers with an overview of mass spectrometry-based glycoproteomics of prostate cancer. From this pe
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16

Iwami, Shingo, Hiroshi Haeno, and Franziska Michor. "A Race between Tumor Immunoescape and Genome Maintenance Selects for Optimum Levels of (epi)genetic Instability." PLoS Computational Biology 8, no. 2 (2012): e1002370. http://dx.doi.org/10.1371/journal.pcbi.1002370.

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17

Ridolfi, Ruggero, Massimo Guidoboni, and Laura Ridolfi. "Cancer immunoediting and dioxin-activating aryl hydrocarbon receptor: a missing link in the shift toward tumor immunoescape?" Journal of Nucleic Acids Investigation 1, no. 1 (2010): 6. http://dx.doi.org/10.4081/jnai.2010.1724.

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The aryl hydrocarbon receptor (AhR), a member of the PAS protein family, is found in organisms as diverse as Drosophila melano­gaster, nematodes, and mammals. While several reviews have reported that AhR, once activated by agonist ligands, causes long-term effects such as modification of cell growth through cell cycle control, there is also recent evidence of its decisive role in immunosuppression. The most widely studied AhR agonist is 2,3,7,8-tetrachlorodibenzo-p-dioxin, which binds AhR with the highest known affinity, leading to profound suppression of both humoral and cellular immune respo
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18

Gevorkian, Jonathan, Hein W. Verspaget, Daniel W. Hommes, Lin Chang, Charalabos Pothoulakis, and Stavroula Baritaki. "Mo1872 Corticotropin-Releasing Hormone Receptor 2 (CRHR2) Inhibits Colorectal Cancer Immunoescape Through Regulation of Fas/FasL Signaling." Gastroenterology 148, no. 4 (2015): S—732. http://dx.doi.org/10.1016/s0016-5085(15)32501-4.

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19

Cheng, An Ning, Li-Chun Cheng, Cheng-Liang Kuo, et al. "Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1–mediated immunoescape via STING-IFN signaling and extracellular vesicles." Journal for ImmunoTherapy of Cancer 8, no. 2 (2020): e001372. http://dx.doi.org/10.1136/jitc-2020-001372.

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BackgroundMitochondrial Lon is a chaperone and DNA-binding protein that functions in protein quality control and stress response pathways. The level of Lon regulates mitochondrial DNA (mtDNA) metabolism and the production of mitochondrial reactive oxygen species (ROS). However, there is little information in detail on how mitochondrial Lon regulates ROS-dependent cancer immunoescape through mtDNA metabolism in the tumor microenvironment (TME).MethodsWe explored the understanding of the intricate interplay between mitochondria and the innate immune response in the inflammatory TME.ResultsWe fou
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20

Chimal-Ramírez, G. K., N. A. Espinoza-Sánchez, and E. M. Fuentes-Pananá. "Protumor Activities of the Immune Response: Insights in the Mechanisms of Immunological Shift, Oncotraining, and Oncopromotion." Journal of Oncology 2013 (2013): 1–16. http://dx.doi.org/10.1155/2013/835956.

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Experimental and clinical studies indicate that cells of the innate and adaptive immune system have both anti- and pro-tumor activities. This dual role of the immune system has led to a conceptual shift in the role of the immune system’s regulation of cancer, in which immune-tumor cell interactions are understood as a dynamic process that comprises at least five phases: immunosurveillance, immunoselection, immunoescape, oncotraining, and oncopromotion. The tumor microenvironment shifts immune cells to perform functions more in tune with the tumor needs (oncotraining); these functions are relat
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21

Liapis, Ioannis, and Stavroula Baritaki. "COVID-19 vs. Cancer Immunosurveillance: A Game of Thrones within an Inflamed Microenviroment." Cancers 14, no. 17 (2022): 4330. http://dx.doi.org/10.3390/cancers14174330.

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The COVID-19 pandemic accounts for more than 500 million confirmed infections and over 6 million deaths worldwide in the last 2 years. SARS-CoV-2 causes a highly complex form of inflammation that affects the human organism both acutely and chronically. In the same line, cancer as an inflammation-induced and immune-editing disease appears to cross-react with immune system at different levels including early interactions during carcinogenesis and later cross-talks within the tumor microenvironment. With all that in mind, a reasonable question one might address is whether the SARS-CoV-2 infection
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22

Torretta, Enrica, Micaela Garziano, Mariacristina Poliseno, et al. "Severity of COVID-19 Patients Predicted by Serum Sphingolipids Signature." International Journal of Molecular Sciences 22, no. 19 (2021): 10198. http://dx.doi.org/10.3390/ijms221910198.

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The reason behind the high inter-individual variability in response to SARS-CoV-2 infection and patient’s outcome is poorly understood. The present study targets the sphingolipid profile of twenty-four healthy controls and fifty-nine COVID-19 patients with different disease severity. Sera were analyzed by untargeted and targeted mass spectrometry and ELISA. Results indicated a progressive increase in dihydrosphingosine, dihydroceramides, ceramides, sphingosine, and a decrease in sphingosine-1-phosphate. These changes are associated with a serine palmitoyltransferase long chain base subunit 1 (
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23

Youlin, Kuang, He Weiyang, Liang Simin та Gou Xin. "Prostaglandin E2 Inhibits Prostate Cancer Progression by Countervailing Tumor Microenvironment-Induced Impairment of Dendritic Cell Migration through LXRα/CCR7 Pathway". Journal of Immunology Research 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/5808962.

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Migration and homing of dendritic cells (DCs) to lymphoid organs are quite crucial for T cell-induced immune response against tumor. However, tumor microenvironment can make some tumor cells escape immune response by impairing DC migration. Prostaglandin E2 (PGE2) plays important roles in initiating and terminating inflammatory responses. In this study, we investigated whether PGE2 could inhibit murine prostate cancer progression by countervailing tumor microenvironment-induced impairment of dendritic cell migration. We found that murine prostate cancer cell line RM-1-conditioned medium impair
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24

Kovar, Marek, Jakub Tomala, Helena Chmelova, et al. "Overcoming Immunoescape Mechanisms of BCL1 Leukemia and Induction of CD8+ T-Cell–Mediated BCL1-Specific Resistance in Mice Cured by Targeted Polymer-Bound Doxorubicin." Cancer Research 68, no. 23 (2008): 9875–83. http://dx.doi.org/10.1158/0008-5472.can-08-1979.

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25

Porcellato, Ilaria, Chiara Brachelente, Livia De Paolis, et al. "FoxP3 and IDO in Canine Melanocytic Tumors." Veterinary Pathology 56, no. 2 (2018): 189–99. http://dx.doi.org/10.1177/0300985818808530.

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Human melanoma is one of the deadliest forms of cancer, with poor prognosis and high resistance to chemotherapy and radiotherapy. The discovery of immunosuppressive mechanisms in the human melanoma microenvironment led to the use of new prognostic markers and to the development of immunotherapies targeting immune checkpoint molecules. Immunoescape mechanisms in canine melanoma have not yet been investigated, and no such immunotherapy has been tested. The aim of this study was to provide preliminary data on the expression of transcription factor forkhead box protein P3 (FoxP3) and indoleamine 2
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26

Fedders, Henning, Ameera Alsadeq, Britt-Sabina Petersen, et al. "Analyses of a Pair of Concordant Twins with Infant ALL and Discordant Clinical Outcome Reveals Immunoescape As a Mechanism of Disease Persistence in MLL-Rearranged Leukemia." Blood 124, no. 21 (2014): 3791. http://dx.doi.org/10.1182/blood.v124.21.3791.3791.

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Abstract MLL-fusion is the most common genetic abnormality in acute lymphoblastic leukemia (ALL) of infancy and occurs in approximately 80% of the cases. Infant ALL represents a biologically distinctive entity with a highly immature pro-B immunophenotype associated with a particularly unfavorable prognosis due to a high proportion of early relapses. This may be due to the survival of dormant residual disease protected by the bone marrow niche. We have characterized a pair of monozygotic twin sisters diagnosed with ALL in early infancy. Tumor cells from both children carried the t(11;19) transl
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27

Gorain, Bapi, Hira Choudhury, Gan Sook Yee, and Subrat Kumar Bhattamisra. "Adenosine Receptors as Novel Targets for the Treatment of Various Cancers." Current Pharmaceutical Design 25, no. 26 (2019): 2828–41. http://dx.doi.org/10.2174/1381612825666190716102037.

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Adenosine is a ubiquitous signaling nucleoside molecule, released from different cells within the body to act on vasculature and immunoescape. The physiological action on the proliferation of tumour cell has been reported by the presence of high concentration of adenosine within the tumour microenvironment, which results in the progression of the tumour, even leading to metastases. The activity of adenosine exclusively depends upon the interaction with four subtypes of heterodimeric G-protein-coupled adenosine receptors (AR), A1, A2A, A2B, and A3-ARs on the cell surface. Research evidence supp
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Tsoukalas, Nikolaos, Ioannis Kostakis, Spiros Siakavellas, et al. "The value of RCAS1 as a potential biomarker in non-small cell lung cancers." Journal of Clinical Oncology 30, no. 15_suppl (2012): e21098-e21098. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e21098.

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e21098 Background: RCAS1 (Receptor-binding Cancer Antigen expressed on SiSo cells) is a membrane protein that is expressed in different types of cancer. It halts the cell cycle and/or induces the apoptosis of the immune system cells within the tumour microenvironment. Hence, it is possible that this molecule is involved in the mechanism of the tumour cells’ escape from the immune system surveillance (immunoescape). Methods: Patients with primary non small cell lung cancer, initially eligible for surgical treatment, were included. The tissue samples (paraffin cubes) were processed using the Tis
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Ortego, Ignacio, Angel María Vizcay, Susana De La Cruz, et al. "Impact of dendritic cell vaccines added to neoadjuvant CT on pathological complete responses in early breast cancer patients according to PD-L1 expression." Journal of Clinical Oncology 39, no. 15_suppl (2021): 585. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.585.

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585 Background: Breast cancer (BC) in early stages exhibit a naïve and competent immune system that translates into a more prominent TIL infiltration and higher PD-L1 expression as compared to the advanced BC scenario were immunoescape and exhaustion are more prevalent. Expression of PD-L1 has been related to a better pCR when immune checkpoint inhibitors (IPI) have been added to neaodjuvant chemotherapy (NACT) in triple negative BC (TNBC). Our prior results shown dendritic cells vaccines (DCV) increased pCR in both TNBC and luminal B subtypes, with an absolute gain of 20% (p = 0.03) and a saf
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30

Guéry, Thomas, Christophe Roumier, Céline Berthon, et al. "The B7-H3 Protein In Acute Myeloid Leukemia." Blood 122, no. 21 (2013): 2620. http://dx.doi.org/10.1182/blood.v122.21.2620.2620.

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Abstract Introduction The B7 family of costimulatory molecules comprises several members, such as PD-L1 (B7-H1), that may participate in the immunoescape of tumor cells. For instance, the expression of PD-L1 in cancer cells can induce immunotolerance by deactivating T cells in several hematological malignancies, including acute myeloid leukemia (AML) and MDS. The B7-H3 (B7-homolog 3 or CD276) is a type I transmembrane protein and a member of the B7 family. B7-H3 is expressed in many tissues and in antigen-presenting cells. Its functions and counter receptor(s) remain unclear. The expression of
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31

Ramsay, Alan G., Andrew J. Clear, Alexander Davenport, Rewas Fatah, and John G. Gribben. "Chronic Lymphocytic Leukemia Cells Co-Opt CD200, CD270, CD274 and CD276 to Induce Impaired Actin Polarization At the T Cell Immune Synapse." Blood 118, no. 21 (2011): 802. http://dx.doi.org/10.1182/blood.v118.21.802.802.

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Abstract Abstract 802 We have previously demonstrated that impaired formation of the T cell immunological synapse in response to autologous (auto) antigen-presenting cells (APCs) is a global immunosuppressive mechanism in chronic lymphocytic leukemia (CLL) (J Clin Invest. 2008;118(7):2427-2437). Polymerization of F-actin beneath the area of the T cell:APC contact site generates a structural support for signaling molecules to assemble and regulate appropriate CD4+ T cell activation and cytolytic CD8+ T cell (CTL) effector function. Importantly, direct contact interaction with tumor cells was sh
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32

Huang, Bo, and Xuetao Cao. "Metabolically targeting immunosuppression and immunoescape for future cancer immunotherapy: a narrative review." Holistic Integrative Oncology 1, no. 1 (2022). http://dx.doi.org/10.1007/s44178-022-00018-5.

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AbstractCancer immunotherapy has emerged as the most important new approach to cancer treatments and moved rapidly to front-line therapy for certain types of cancers. However, both tumor microenvironments and tumor cells can mediate immunosuppression and immunoescape, thus dampening the efficacy of immunotherapy. Despite the complicacies, mechanistic illuminations of unknown immunosuppression and immunoescape are of paramount importance. This short review highlights the recent important findings in cancer immunology and immunotherapy, thus providing new insights into cancer immunosuppression,
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33

Kresno, Siti Boedina. "Cancer Immunology: From Immunosurveillance to Immunoescape." Indonesian Journal of Cancer 2, no. 1 (2008). http://dx.doi.org/10.33371/ijoc.v2i1.33.

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Sejak lama telah diketahui bahwa sistem imun dapat mengidentifikasi dan menyingkirkan sel tumor berdasarkan ekspresi antigen tumor atau molekul yang diinduksi oleh stres pada sel. Proses ini dikenal sebagai tumor immunosurveillance, pada proses mana sistem imun mengidentifikasi sel kanker dan sel prekanker kemudian menghancurkannya sebelum sel itu menjadi berbahaya. Berbagai sel efektor, seperti sel B, T, NK, NKT, IFN, perforin dan granzyme telah sejak lama diketahui secara jelas peranannya dalam immunosurveillance. Walaupun telah jelas bahwa ada immunosurveillance dan sel kanker dapat dikenal
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34

Concha-Benavente, Fernando, and Robert L. Ferris. "Reversing EGFR Mediated Immunoescape by Targeted Monoclonal Antibody Therapy." Frontiers in Pharmacology 8 (May 30, 2017). http://dx.doi.org/10.3389/fphar.2017.00332.

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35

Wang, Yunfei, Kaikai Yi, Xing Liu та ін. "HOTAIR Up-Regulation Activates NF-κB to Induce Immunoescape in Gliomas". Frontiers in Immunology 12 (23 листопада 2021). http://dx.doi.org/10.3389/fimmu.2021.785463.

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BackgroundCheckpoint blockade therapies targeting programmed death ligand 1 (PD-L1) and its receptor programmed cell death 1 promote T cell-mediated immune surveillance against tumors and have been associated with significant clinical benefit in cancer patients. The long-stranded non-coding RNA HOTAIR is highly expressed and associated with metastasis in a variety of cancer types and promotes tumor metastasis at least in part through association with the PRC2 complex that induces redirection to hundreds of genes involved in tumor metastasis. Here, we report that HOTAIR is an activator lncRNA o
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36

Porcellato, Ilaria, Chiara Brachelente, Katia Cappelli, et al. "FoxP3, CTLA-4, and IDO in Canine Melanocytic Tumors." Veterinary Pathology, October 6, 2020, 030098582096013. http://dx.doi.org/10.1177/0300985820960131.

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Despite promising immunotherapy strategies in human melanoma, there are few studies on the immune environment of canine melanocytic tumors. In humans, the activation of immunosuppressive cell subpopulations, such as regulatory T cells (Tregs) that express forkhead box protein P3 (FoxP3), the engagement of immunosuppressive surface receptors like cytotoxic T lymphocyte antigen (CTLA-4), and the secretion of molecules inhibiting lymphocyte activation, such as indoleamine-pyrrole 2,3-dioxygenase (IDO), are recognized as immunoescape mechanisms that allow tumor growth and progression. The aim of o
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Kuo, Cheng-Liang, Ananth Ponneri Babuharisankar, Ying-Chen Lin, et al. "Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?" Journal of Biomedical Science 29, no. 1 (2022). http://dx.doi.org/10.1186/s12929-022-00859-2.

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AbstractThe major concept of "oxidative stress" is an excess elevated level of reactive oxygen species (ROS) which are generated from vigorous metabolism and consumption of oxygen. The precise harmonization of oxidative stresses between mitochondria and other organelles in the cell is absolutely vital to cell survival. Under oxidative stress, ROS produced from mitochondria and are the major mediator for tumorigenesis in different aspects, such as proliferation, migration/invasion, angiogenesis, inflammation, and immunoescape to allow cancer cells to adapt to the rigorous environment. According
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38

Lei, Xinyuan, Hsinyu Lin, Jieqi Wang, et al. "Mitochondrial fission induces immunoescape in solid tumors through decreasing MHC-I surface expression." Nature Communications 13, no. 1 (2022). http://dx.doi.org/10.1038/s41467-022-31417-x.

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AbstractMitochondrial dynamics can regulate Major Histocompatibility Complex (MHC)-I antigen expression by cancer cells and their immunogenicity in mice and in patients with malignancies. A crucial role in the mitochondrial fragmentation connection with immunogenicity is played by the IRE1α-XBP-1s axis. XBP-1s is a transcription factor for aminopeptidase TPP2, which inhibits MHC-I complex cell surface expression likely by degrading tumor antigen peptides. Mitochondrial fission inhibition with Mdivi-1 upregulates MHC-I expression on cancer cells and enhances the efficacy of adoptive T cell ther
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Pan, Jinghua, Yiting Qiao, Congcong Chen, et al. "USP5 facilitates non-small cell lung cancer progression through stabilization of PD-L1." Cell Death & Disease 12, no. 11 (2021). http://dx.doi.org/10.1038/s41419-021-04356-6.

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AbstractPD-L1(CD274) is a well-known immunosuppressive molecule, which confers immunoescape features to cancer cells and has become one of the major targets in cancer immunotherapies. Understanding the regulatory mechanisms that control PD-L1 protein expression is important for guiding immune checkpoint blockade therapy. Here, we showed that ubiquitin specific peptidase 5 (USP5) was a novel PD-L1 deubiquitinase in non-small cell lung cancer (NSCLC) cells. USP5 directly interacted with PD-L1 and deubiquitinated PD-L1, therefore enhances PD-L1 protein stability. Meanwhile, USP5 protein levels we
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Braumüller, Heidi, Bernhard Mauerer, Christopher Berlin, et al. "Senescent Tumor Cells in the Peritoneal Carcinomatosis Drive Immunosenescence in the Tumor Microenvironment." Frontiers in Immunology 13 (June 30, 2022). http://dx.doi.org/10.3389/fimmu.2022.908449.

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More than half of all patients with colorectal cancer (CRC) develop distant metastasis and, depending on the local stage of the primary tumor, up to 48% of patients present peritoneal carcinomatosis (PC). PC is often considered as a widespread metastatic disease, which is almost resistant to current systemic therapies like chemotherapeutic and immunotherapeutic regimens. Here we could show that tumor cells of PC besides being senescent also exhibit stem cell features. To investigate these surprising findings in more detail, we established a murine model based on tumor organoids that resembles
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Bogéa, Gabriela Muller Reche, Amandda Évelin Silva-Carvalho, Luma Dayane de Carvalho Filiú-Braga, Francisco de Assis Rocha Neves, and Felipe Saldanha-Araujo. "The Inflammatory Status of Soluble Microenvironment Influences the Capacity of Melanoma Cells to Control T-Cell Responses." Frontiers in Oncology 12 (March 28, 2022). http://dx.doi.org/10.3389/fonc.2022.858425.

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The development of immunotherapeutic approaches for the treatment of melanoma requires a better understanding of immunoescape mechanisms of tumor cells and how they interact with other tumor-resident cell types. Here, we evaluated how the conditioned media of resting (rCM) and immune-activated PBMCs (iCM) influence the ability of a metastatic melanoma cell line (MeWo) to control T-cells function. MeWo cells were expanded in RPMI, rCM, or iCM and the secretome generated after cell expansion was identified as MeSec (RPMI), niSec (non-inflammatory), or iSec (inflammatory secretome), respectively.
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Alsadeq, A., H. Fedders, BS Petersen, et al. "A Case of Concordant Twins with Infant ALL and Discordant Clinical Outcome – Part II: highlights on an immunoescape phenotype as a potential mechanism of disease persistence." Klinische Pädiatrie 227, no. 03 (2015). http://dx.doi.org/10.1055/s-0035-1550250.

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43

Moyano, Ana, Oscar Blanch-Lombarte, Laura Tarancon-Diez, et al. "Immunoescape of HIV-1 in Env-EL9 CD8 + T cell response restricted by HLA-B*14:02 in a Non progressor who lost twenty-seven years of HIV-1 control." Retrovirology 19, no. 1 (2022). http://dx.doi.org/10.1186/s12977-022-00591-7.

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Abstract Background Long-Term Non-Progressors (LTNPs) are untreated Human Immunodeficiency virus type 1 (HIV-1) infected individuals able to control disease progression for prolonged periods. However, the LTNPs status is temporary, as viral load increases followed by decreases in CD4 + T-cell counts. Control of HIV-1 infection in LTNPs viremic controllers, have been associated with effective immunodominant HIV-1 Gag-CD8 + T-cell responses restricted by protective HLA-B alleles. Individuals carrying HLA-B*14:02 control HIV-1 infection is related to an immunodominant Env-CD8 + T-cell response. L
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